melphalan and Diabetes-Mellitus

In patients with relapsed or refractory lymphoma, high-dose chemoimmunotherapy with subsequent autologous hematopoietic cell transplantation (HCT) is a standard of care. Bendamustine, an alkylating agent, is used in the BeEAM (bendamustine, etoposide, cytarabine, melphalan) protocol for conditioning therapy before autologous HCT in patients with relapsed or refractory lymphoma who are eligible for transplant. There is no consensus regarding an optimal salvage regimen and the approach varies according to toxicity.. We present a case of partial nephrogenic diabetes insipidus after receiving bendamustine, as part of the BeEAM protocol.. We summarize published reports of bendamustine-induced diabetes insipidus.

Topics: Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Cytarabine; Diabetes Insipidus, Nephrogenic; Diabetes Mellitus; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Melphalan; Transplantation, Autologous