melphalan and Carcinogenesis

melphalan has been researched along with Carcinogenesis* in 1 studies

Other Studies

1 other study(ies) available for melphalan and Carcinogenesis

Article	Year
A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma. Scientific reports, 2018, 10-23, Volume: 8, Issue:1 Persistent or recurrent retinoblastoma (RB) is associated with the presence of vitreous or/and subretinal seeds in advanced RB and represents a major cause of therapeutic failure. This necessitates the development of novel therapies and thus requires a model of advanced RB for testing candidate therapeutics. To this aim, we established and characterized a three-dimensional, self-organizing organoid model derived from chemotherapy-naïve tumors. The responses of organoids to drugs were determined and compared to relate organoid model to advanced RB, in terms of drug sensitivities. We found that organoids had histological features resembling retinal tumors and seeds and retained DNA copy-number alterations as well as gene and protein expression of the parental tissue. Cone signal circuitry (M/L Topics: Antineoplastic Agents; Carcinogenesis; Child, Preschool; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Humans; Infant; Melphalan; Models, Biological; Neoplasm Staging; Organoids; Retinal Neoplasms; Retinoblastoma; Topotecan	2018

Article

Year

A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma.

Scientific reports, 2018, 10-23, Volume: 8, Issue:1

Persistent or recurrent retinoblastoma (RB) is associated with the presence of vitreous or/and subretinal seeds in advanced RB and represents a major cause of therapeutic failure. This necessitates the development of novel therapies and thus requires a model of advanced RB for testing candidate therapeutics. To this aim, we established and characterized a three-dimensional, self-organizing organoid model derived from chemotherapy-naïve tumors. The responses of organoids to drugs were determined and compared to relate organoid model to advanced RB, in terms of drug sensitivities. We found that organoids had histological features resembling retinal tumors and seeds and retained DNA copy-number alterations as well as gene and protein expression of the parental tissue. Cone signal circuitry (M/L

Topics: Antineoplastic Agents; Carcinogenesis; Child, Preschool; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Humans; Infant; Melphalan; Models, Biological; Neoplasm Staging; Organoids; Retinal Neoplasms; Retinoblastoma; Topotecan

2018