melphalan and Capillary-Leak-Syndrome

Topics: Capillary Leak Syndrome; Combined Modality Therapy; Drug Therapy, Combination; Humans; Hypotension; Immunoglobulins, Intravenous; Immunosuppressive Agents; Intestinal Perforation; Male; Melphalan; Middle Aged; Monoclonal Gammopathy of Undetermined Significance; Prednisone; Sepsis; Sympathomimetics; Terbutaline; Theophylline

Topics: Anti-Inflammatory Agents; Capillary Leak Syndrome; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Melphalan; Middle Aged; Myeloablative Agonists; Prednisone

Cytotoxicity of drugs can be a cause of cardiorespiratory disorders connected with chemotherapy. Doxorubicin is an antibiotic from the group of anthracyclines effective in antineoplastic therapy of solid and hematopoetic tumors. The most common cause of therapy ceasing is its cardiotoxicity. However, a lung injury connected with its cytotoxic activity to pulmonary endothelium (capillary leak syndrome) can be an equally serious complication. In the case presented, rapid, multi-profile diagnostics with the use of impedance cardiography, a modern noninvasive tool of hemodynamic monitoring, led to the recognition and effective treatment of a rare clinical syndrome.

Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capillary Leak Syndrome; Cardiography, Impedance; Cyclophosphamide; Doxorubicin; Humans; Lung; Male; Melphalan; Multiple Myeloma; Prednisone; Retreatment; Treatment Outcome; Vincristine

Topics: Adult; Anesthetics, Inhalation; Capillary Leak Syndrome; Chemotherapy, Cancer, Regional Perfusion; Desflurane; Hemodynamics; Humans; Hyperthermia, Induced; Isoflurane; Leg; Male; Melanoma; Melphalan