melphalan and Blood-Protein-Disorders

Topics: Animals; Antibody-Producing Cells; Blood Protein Disorders; Clone Cells; Cyclophosphamide; Humans; Immunoglobulins; Melphalan; Mice; Multiple Myeloma; Plasma Cells

Report on a 74-year-old patient who developed acute myeloid leukemia 16 months after diagnosis of IgA paraproteinemia. He had received a total dose of 1.4-1.5 g melphalan. The possible etiologic role of melphalan in the development of acute leukemia is discussed.

Topics: Aged; Blood Protein Disorders; Blood Protein Electrophoresis; Humans; Immunoglobulin A; Leukemia, Myeloid, Acute; Male; Melphalan; Time Factors

Topics: Adult; Blood Protein Disorders; Dexamethasone; Drug Therapy, Combination; Female; Humans; Melphalan; Plasmacytoma; Remission, Spontaneous

The designation "pseudomyeloma'' is used to describe three patients who had a clinical picture that closely resembled multiple myeloma and was characterized by severe osteoporosis and a serum monoclonal paraprotein peak. The diagnosis of myeloma could not be made histologically, initally or after three, four, or ten years of observation. The protein abnormalities and the bone marrow picture remained stable. It is not known if this association has pathophysiologic importance or if it represents a chance phenomenon.

Topics: Blood Protein Disorders; Blood Sedimentation; Bone Marrow Examination; Cyclophosphamide; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Immunoglobulins; Male; Melphalan; Middle Aged; Multiple Myeloma; Osteoporosis

Topics: Aged; Angina Pectoris; Blood Protein Disorders; Blood Viscosity; Humans; Immunoglobulin G; Male; Melphalan; Myeloma Proteins; Plasmapheresis

Topics: Aged; Autopsy; Blood Cell Count; Blood Protein Disorders; Blood Protein Electrophoresis; Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; Humans; Immunoelectrophoresis; Immunoglobulin G; Leukemia, Myeloid; Male; Melphalan; Multiple Myeloma; Prednisone

Topics: Adult; Blood Protein Disorders; Blood Protein Electrophoresis; Bone Marrow; Bone Marrow Cells; Brain Edema; Bronchopneumonia; Chondroitin; Culture Techniques; Fluorescent Antibody Technique; Glycoproteins; Humans; Hyaluronic Acid; Immunoelectrophoresis; Immunoglobulin G; Male; Melphalan; Myxedema; Skin; Skin Diseases; Sulfuric Acids

Topics: Adult; Blood Protein Disorders; Blood Protein Electrophoresis; Blood Proteins; Cold Temperature; Female; Humans; Immune Sera; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Leg; Melphalan; Multiple Myeloma; Precipitin Tests; Prednisone; Purpura; Skin Manifestations

Topics: Adult; Aged; Amyloid; Amyloidosis; Bence Jones Protein; Biopsy; Blood Protein Disorders; Electrophoresis; Female; Humans; Kidney Diseases; Male; Melphalan; Middle Aged; Proteinuria; Time Factors

Topics: Agammaglobulinemia; Antibodies; Antigens, Bacterial; Blood Protein Disorders; Blood Proteins; Busulfan; Chlorambucil; Electrophoresis, Paper; Hodgkin Disease; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulins; Immunosuppression Therapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mannomustine; Melphalan; Primary Myelofibrosis; Radiation Effects; Saliva; Skin Tests; Spleen; Time Factors

Topics: Adenoma; Adolescent; Adult; Aged; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sideroblastic; Blood Protein Disorders; Chlorambucil; Female; Hemoglobinometry; Humans; Immunosuppressive Agents; Kidney Neoplasms; Leukemia; Lupus Erythematosus, Systemic; Male; Melphalan; Multiple Myeloma; Polycythemia; Pyridoxine; Waldenstrom Macroglobulinemia

Topics: Adult; Blood Coagulation; Blood Protein Disorders; Blood Protein Electrophoresis; Cryoglobulins; Humans; Immunoglobulin M; Leukemia, Erythroblastic, Acute; Male; Melphalan; Time Factors

Topics: Blood Protein Disorders; Cryoglobulins; Cyclophosphamide; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Melphalan

Topics: Age Factors; Antibody Formation; Arteritis; Bence Jones Protein; Blood Protein Disorders; Blood Protein Electrophoresis; Clone Cells; Cyclophosphamide; Female; gamma-Globulins; Humans; Hypergammaglobulinemia; Immunochemistry; Leukemia, Lymphoid; Lymphocytes; Macroglobulins; Male; Melphalan; Multiple Myeloma; Plasma Cells; Terminology as Topic; Waldenstrom Macroglobulinemia

Topics: Adrenal Cortex Hormones; Adult; Age Factors; Blood Protein Disorders; Chlorambucil; Humans; Immunity, Cellular; Immunoelectrophoresis; Immunoglobulin G; Immunoglobulins; Intestinal Absorption; Intestine, Small; Jejunum; Lymphoma; Malabsorption Syndromes; Male; Melphalan; Microscopy, Electron; Racial Groups; Saliva

Topics: Adult; Aged; Blood Protein Disorders; Diagnosis, Differential; Female; Humans; Immunoglobulin G; Immunoglobulins; Immunosuppressive Agents; Male; Melphalan; Methotrexate; Middle Aged; Multiple Myeloma; Myxedema; Scleroderma, Systemic; Serum Globulins; Skin Diseases

Topics: Blood Protein Disorders; gamma-Globulins; Humans; Male; Melphalan; Middle Aged; Sclerosis; Skin Diseases

Topics: Anemia, Hemolytic; Blood Protein Disorders; Chlorambucil; Cryoglobulins; Cyclophosphamide; Diagnosis, Differential; Heavy Chain Disease; Humans; Melphalan; Neoplasms; Plasmacytoma; Waldenstrom Macroglobulinemia

Topics: Blood Protein Disorders; Cyclophosphamide; Humans; Melphalan; Plasmacytoma; Statistics as Topic; Waldenstrom Macroglobulinemia

Topics: Alkylating Agents; Animals; Blood Protein Disorders; Blood Protein Electrophoresis; Cyclophosphamide; Melphalan; Rats; Sarcoma, Experimental; Thiotepa

Topics: Blood Protein Disorders; Cyclophosphamide; DNA; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Melphalan; Multiple Myeloma

Topics: Blood Protein Disorders; Blood Protein Electrophoresis; Humans; Immunoelectrophoresis; Immunoglobulin G; Male; Melphalan; Middle Aged; Multiple Myeloma; Myasthenia Gravis

Topics: Anemia; Blood Protein Disorders; Chlorambucil; Humans; Hypercalcemia; Leukopenia; Melphalan; Plasmacytoma; Thrombocytopenia

Topics: Blood Protein Disorders; Blood Protein Electrophoresis; Cyclophosphamide; gamma-Globulins; Humans; Immunoelectrophoresis; Lymphatic Diseases; Melphalan; Multiple Myeloma; Plasmacytoma; Skeleton; Waldenstrom Macroglobulinemia

Topics: Aged; Blood Protein Disorders; Female; Humans; Immunoelectrophoresis; Melphalan; Middle Aged; Multiple Myeloma

Topics: Beta-Globulins; Blood Protein Disorders; Blood Protein Electrophoresis; Clavicle; Drug Therapy; gamma-Globulins; Geriatrics; Immunoglobulin G; Melphalan; Multiple Myeloma; Myelography; Neoplasms; Radiography; Spinal Neoplasms

Topics: Amyloidosis; Anniversaries and Special Events; Blood Protein Disorders; Cryoglobulins; Drug Therapy; Hemorrhagic Disorders; Humans; Melphalan; Multiple Myeloma

Topics: Blood Protein Disorders; Blood Protein Electrophoresis; Cyclophosphamide; Drug Therapy; gamma-Globulins; Geriatrics; Hospitals, General; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Melphalan; Multiple Myeloma; Myeloma Proteins; Neoplasms; Vascular Diseases; Waldenstrom Macroglobulinemia