melphalan and Anemia--Sideroblastic

Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Sideroblastic; Blood Transfusion; Bone Marrow; Chloramphenicol; Deferoxamine; Erythroblasts; Ethanol; Female; Ferrochelatase; Heme; Hemochromatosis; Humans; Iron Deficiencies; Isoniazid; Male; Melphalan; Myeloproliferative Disorders; Pyridoxine; Syndrome

Two patients with IgA myeloma and one patient with kappa light chain disease developed sideroblastic anaemia from two to four years after the initial diagnosis. All had previously received radiotherapy and chemotherapy (melphalan and prednisone). In two patients the myeloma was quiescent when the sideroblastic change occurred. Leukaemia occurred in two patients two and seven months respectively after the diagnosis of sideroblastic anaemia was made. In one of them, the myeloma became active again at the same time. The development of sideroblastic anaemia may be a pre-leukaemic event and may be recognised by the appearance of a dimorphic blood film.

Topics: Anemia, Sideroblastic; Female; Humans; Immunoglobulin A; Immunoglobulin kappa-Chains; Leukemia; Male; Melphalan; Middle Aged; Multiple Myeloma; Prednisone; Preleukemia

Topics: Aged; Anemia, Sideroblastic; Female; Humans; Leukemia, Myeloid, Acute; Male; Melphalan; Middle Aged; Multiple Myeloma

Topics: Adenocarcinoma; Aged; Anemia, Sideroblastic; Cecal Neoplasms; Female; Humans; Male; Melphalan; Middle Aged; Multiple Myeloma; Radioisotope Teletherapy; Spinal Neoplasms; Thrombocythemia, Essential

Topics: Anemia, Sideroblastic; Bone Marrow Examination; Cytarabine; Female; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulins; Iron; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Melphalan; Mercaptopurine; Middle Aged; Multiple Myeloma; Muramidase; Precancerous Conditions; Prednisone; Staining and Labeling; Vincristine

Topics: Adenoma; Adolescent; Adult; Aged; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sideroblastic; Blood Protein Disorders; Chlorambucil; Female; Hemoglobinometry; Humans; Immunosuppressive Agents; Kidney Neoplasms; Leukemia; Lupus Erythematosus, Systemic; Male; Melphalan; Multiple Myeloma; Polycythemia; Pyridoxine; Waldenstrom Macroglobulinemia

Topics: Aged; Anemia, Sideroblastic; Blood Platelets; Female; Hemoglobinometry; Humans; Leukocyte Count; Leukopenia; Male; Melphalan; Polycythemia Vera; Primary Myelofibrosis