melitten has been researched along with Carcinoma--Ehrlich-Tumor* in 1 studies
1 other study(ies) available for melitten and Carcinoma--Ehrlich-Tumor
| Article | Year |
|---|---|
Protection of cells against membrane damage by haemolytic agents: divalent cations and protons act at the extracellular side of the plasma membrane.
The protective effect of Ca2+, Zn2+ and H+ against membrane damage induced by different haemolytic agents has been studied by measuring monovalent cation leakage and haemolysis of erythrocytes, and phosphoryl[3H]choline and adenine nucleotide leakage from Lettre cells prelabelled with [3H]choline. The protective effect of Ca2+ and Zn2+ on erythrocytes damaged by Staphylococcus aureus alpha-toxin, Sendai virus or melittin is unaffected by the addition of A23187, even though this ionophore greatly increases the uptake of 45Ca2+ or 65Zn2+. The same result has been found for the protective effect of Zn2+ on Lettre cells damaged by S. aureus alpha-toxin, Sendai virus, melittin or Triton X-100. Leakage of phosphoryl[3H]choline from prelabelled Lettre cells is inhibited if extracellular pH is lowered; lowering the intracellular pH without affecting the extracellular pH, affords little protection. It is concluded that Ca2+, Zn2+ and H+ protect cells against membrane damage induced by haemolytic agents by an action at the extracellular side of the plasma membrane. Topics: Animals; Bacterial Toxins; Calcimycin; Calcium; Carcinoma, Ehrlich Tumor; Cations, Divalent; Cell Membrane; Cell Membrane Permeability; Erythrocyte Membrane; Hemolysin Proteins; Humans; Kinetics; Melitten; Mice; Parainfluenza Virus 1, Human; Staphylococcus aureus; Zinc | 1989 |