Page last updated: 2024-10-19

melatonin and Tinnitus

melatonin has been researched along with Tinnitus in 17 studies

Tinnitus: A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep."9.12The effects of melatonin on tinnitus and sleep. ( Finnell, JE; Megwalu, UC; Piccirillo, JF, 2006)
"Based on the subjective grading, tinnitus perception diminished by 56% in patients treated with sulpiride, by 40% in patients treated with melatonin, by 81% in patients treated with sulpiride plus melatonin, and by 22% in patients treated with placebo."9.12Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. ( Esteban-Ortega, F; Lopez-Gonzalez, MA; Santiago, AM, 2007)
"Melatonin has been shown to be useful in the treatment of subjective tinnitus."9.08Effect of melatonin on tinnitus. ( Olds, MJ; Rosenberg, SI; Rowan, PT; Silverstein, H, 1998)
"We performed a review with the purpose to summarise, analyse and discuss the evidence provided by clinical studies evaluating effectiveness of melatonin in the cure of tinnitus."8.91Clinical pharmacology of melatonin in the treatment of tinnitus: a review. ( Bruno, R; Calapai, F; Calapai, G; Galletti, F; Gangemi, S; Miroddi, M; Navarra, M, 2015)
"Melatonin, a hormone produced by the pineal gland, may be a promising treatment option for tinnitus."8.90Does melatonin have therapeutic use in tinnitus? ( Merrick, L; Peiris, AN; Tanner, M; Youssef, D, 2014)
"Melatonin has been proposed as a treatment for tinnitus, especially on the basis of its favourable effects on sleep and its vasoactive and antioxidant properties."8.86Exploring the reasons why melatonin can improve tinnitus. ( Ferri, GG; Pirodda, A; Raimondi, MC, 2010)
"The results of Tinnitus Handicap Inventory (THI) and acufenometry showed a significative improvement of tinnitus after treatment with sulodexide and melatonin."7.81Medical and surgical treatments for tinnitus: the efficacy of combined treatment with sulodexide and melatonin. ( Agnese, A; Cavallero, A; Delehaye, E; Ferrari, G; Rocchetti, O; Rossi, W; Tombolini, A, 2015)
"To determine the correlation between plasma levels of melatonin, vitamin C and vitamin B12 and the presence of tinnitus among elderly subjects with unexplained subjective tinnitus."7.78The role of plasma melatonin and vitamins C and B12 in the development of idiopathic tinnitus in the elderly. ( Fehintola, FA; Lasisi, AO; Lasisi, TJ, 2012)
"Tinnitus is a hearing disorder characterized by the perception of sound without external acoustic stimuli, which is caused by damage to the auditory system in response to excessive levels of noise, ototoxic agents and aging."6.61Molecular Aspects of Melatonin Treatment in Tinnitus: A Review. ( Ghaznavi, H; Hosseinzadeh, A; Kamali, M; Kamrava, SK; Mehrzadi, S; Moore, BCJ; Reiter, RJ, 2019)
" In a dose-response manner, melatonin also reduced vestibular hair cell loss due to gentamicin treatment in explanted utricles of newborn rats."6.47Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. ( Fuentes-Broto, L; Korkmaz, A; Reiter, RJ; Tan, DX, 2011)
" Adults with chronic tinnitus were randomized to 3 mg melatonin or placebo nightly for 30 days followed by a 1-month washout period."5.15Melatonin: can it stop the ringing? ( Dodson, EE; Dome, C; Holloman, CH; Hurtuk, A; Jacob, A; Welling, DB; Wolfe, K, 2011)
"To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep."5.12The effects of melatonin on tinnitus and sleep. ( Finnell, JE; Megwalu, UC; Piccirillo, JF, 2006)
"Based on the subjective grading, tinnitus perception diminished by 56% in patients treated with sulpiride, by 40% in patients treated with melatonin, by 81% in patients treated with sulpiride plus melatonin, and by 22% in patients treated with placebo."5.12Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. ( Esteban-Ortega, F; Lopez-Gonzalez, MA; Santiago, AM, 2007)
"Melatonin has been shown to be useful in the treatment of subjective tinnitus."5.08Effect of melatonin on tinnitus. ( Olds, MJ; Rosenberg, SI; Rowan, PT; Silverstein, H, 1998)
"We performed a review with the purpose to summarise, analyse and discuss the evidence provided by clinical studies evaluating effectiveness of melatonin in the cure of tinnitus."4.91Clinical pharmacology of melatonin in the treatment of tinnitus: a review. ( Bruno, R; Calapai, F; Calapai, G; Galletti, F; Gangemi, S; Miroddi, M; Navarra, M, 2015)
"Melatonin, a hormone produced by the pineal gland, may be a promising treatment option for tinnitus."4.90Does melatonin have therapeutic use in tinnitus? ( Merrick, L; Peiris, AN; Tanner, M; Youssef, D, 2014)
"Melatonin has been proposed as a treatment for tinnitus, especially on the basis of its favourable effects on sleep and its vasoactive and antioxidant properties."4.86Exploring the reasons why melatonin can improve tinnitus. ( Ferri, GG; Pirodda, A; Raimondi, MC, 2010)
"The use of dietary supplements to treat tinnitus is common, particularly with Ginkgo biloba, lipoflavonoids, magnesium, melatonin, vitamin B12, and zinc."3.83Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus. ( Coelho, C; Gantz, BJ; Hansen, MR; Ji, H; Jun, HJ; Rojas-Roncancio, E; Tao, P; Tyler, R; Wang, TC; Witt, S, 2016)
"The results of Tinnitus Handicap Inventory (THI) and acufenometry showed a significative improvement of tinnitus after treatment with sulodexide and melatonin."3.81Medical and surgical treatments for tinnitus: the efficacy of combined treatment with sulodexide and melatonin. ( Agnese, A; Cavallero, A; Delehaye, E; Ferrari, G; Rocchetti, O; Rossi, W; Tombolini, A, 2015)
"To determine the correlation between plasma levels of melatonin, vitamin C and vitamin B12 and the presence of tinnitus among elderly subjects with unexplained subjective tinnitus."3.78The role of plasma melatonin and vitamins C and B12 in the development of idiopathic tinnitus in the elderly. ( Fehintola, FA; Lasisi, AO; Lasisi, TJ, 2012)
"Tinnitus is a hearing disorder characterized by the perception of sound without external acoustic stimuli, which is caused by damage to the auditory system in response to excessive levels of noise, ototoxic agents and aging."2.61Molecular Aspects of Melatonin Treatment in Tinnitus: A Review. ( Ghaznavi, H; Hosseinzadeh, A; Kamali, M; Kamrava, SK; Mehrzadi, S; Moore, BCJ; Reiter, RJ, 2019)
" In a dose-response manner, melatonin also reduced vestibular hair cell loss due to gentamicin treatment in explanted utricles of newborn rats."2.47Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. ( Fuentes-Broto, L; Korkmaz, A; Reiter, RJ; Tan, DX, 2011)
"Melatonin is a neurohormone that is secreted by the pineal gland and known to impact the sleep-wake cycle."2.44Melatonin. ( Piccirillo, JF, 2007)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's1 (5.88)18.2507
2000's4 (23.53)29.6817
2010's11 (64.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hosseinzadeh, A1
Kamrava, SK1
Moore, BCJ1
Reiter, RJ2
Ghaznavi, H1
Kamali, M1
Mehrzadi, S1
Lasisi, AO1
Fehintola, FA1
Lasisi, TJ1
Dion, GR1
Merrick, L1
Youssef, D1
Tanner, M1
Peiris, AN1
Larsen, DG1
Ovesen, T1
Ferrari, G1
Agnese, A1
Cavallero, A1
Delehaye, E1
Rocchetti, O1
Rossi, W1
Tombolini, A1
Miroddi, M1
Bruno, R1
Galletti, F1
Calapai, F1
Navarra, M1
Gangemi, S1
Calapai, G1
Coelho, C1
Tyler, R1
Ji, H1
Rojas-Roncancio, E1
Witt, S1
Tao, P1
Jun, HJ1
Wang, TC1
Hansen, MR1
Gantz, BJ1
Neri, G1
De Stefano, A1
Baffa, C1
Kulamarva, G1
Di Giovanni, P1
Petrucci, G1
Poliandri, A1
Dispenza, F1
Citraro, L1
Croce, A1
Pirodda, A1
Raimondi, MC1
Ferri, GG1
Tan, DX1
Korkmaz, A1
Fuentes-Broto, L1
Hurtuk, A1
Dome, C1
Holloman, CH1
Wolfe, K1
Welling, DB1
Dodson, EE1
Jacob, A1
Megwalu, UC1
Finnell, JE1
Piccirillo, JF2
Lopez-Gonzalez, MA1
Santiago, AM1
Esteban-Ortega, F1
Rudin, DO1
Rosenberg, SI1
Silverstein, H1
Rowan, PT1
Olds, MJ1

Reviews

7 reviews available for melatonin and Tinnitus

ArticleYear
Molecular Aspects of Melatonin Treatment in Tinnitus: A Review.
    Current drug targets, 2019, Volume: 20, Issue:11

    Topics: Apoptosis; Autophagy; Clinical Trials as Topic; Humans; Melatonin; Neuronal Plasticity; Nitrosative

2019
Does melatonin have therapeutic use in tinnitus?
    Southern medical journal, 2014, Volume: 107, Issue:6

    Topics: Animals; Antioxidants; Humans; Melatonin; Tinnitus; Treatment Outcome

2014
[Tinnitus guidelines and treatment].
    Ugeskrift for laeger, 2014, Oct-13, Volume: 176, Issue:42

    Topics: Acoustic Stimulation; Antidepressive Agents; Central Nervous System Depressants; Cognitive Behaviora

2014
Clinical pharmacology of melatonin in the treatment of tinnitus: a review.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:3

    Topics: Antipsychotic Agents; Central Nervous System Depressants; Drug Therapy, Combination; Glycosaminoglyc

2015
Exploring the reasons why melatonin can improve tinnitus.
    Medical hypotheses, 2010, Volume: 75, Issue:2

    Topics: Antioxidants; Humans; Melatonin; Muscle Tonus; Muscle, Skeletal; Sleep; Tensor Tympani; Tinnitus

2010
Drug-mediated ototoxicity and tinnitus: alleviation with melatonin.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2011, Volume: 62, Issue:2

    Topics: Aminoglycosides; Animals; Cisplatin; Controlled Clinical Trials as Topic; Drug-Related Side Effects

2011
Melatonin.
    Progress in brain research, 2007, Volume: 166

    Topics: Animals; Humans; Melatonin; Sleep Wake Disorders; Tinnitus

2007

Trials

5 trials available for melatonin and Tinnitus

ArticleYear
Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study.
    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2009, Volume: 29, Issue:2

    Topics: Administration, Oral; Adult; Female; Glycosaminoglycans; Humans; Male; Melatonin; Middle Aged; Prosp

2009
Melatonin: can it stop the ringing?
    The Annals of otology, rhinology, and laryngology, 2011, Volume: 120, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Depressants; Cross-Over Studies; Double-Blind

2011
The effects of melatonin on tinnitus and sleep.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2006, Volume: 134, Issue:2

    Topics: Adolescent; Adult; Aged; Female; Humans; Male; Melatonin; Middle Aged; Prospective Studies; Sleep; T

2006
Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway.
    The Journal of otolaryngology, 2007, Volume: 36, Issue:4

    Topics: Aged; Auditory Pathways; Dopamine Antagonists; Double-Blind Method; Drug Therapy, Combination; Femal

2007
Effect of melatonin on tinnitus.
    The Laryngoscope, 1998, Volume: 108, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Melat

1998

Other Studies

5 other studies available for melatonin and Tinnitus

ArticleYear
The role of plasma melatonin and vitamins C and B12 in the development of idiopathic tinnitus in the elderly.
    Ghana medical journal, 2012, Volume: 46, Issue:3

    Topics: Aged; Aged, 80 and over; Ascorbic Acid; Chromatography, High Pressure Liquid; Female; Humans; Male;

2012
Commentary on "does melatonin have therapeutic use in tinnitus?".
    Southern medical journal, 2014, Volume: 107, Issue:6

    Topics: Animals; Humans; Melatonin; Tinnitus

2014
Medical and surgical treatments for tinnitus: the efficacy of combined treatment with sulodexide and melatonin.
    Journal of neurosurgical sciences, 2015, Volume: 59, Issue:1

    Topics: Aged; Anticoagulants; Antioxidants; Drug Therapy, Combination; Female; Glycosaminoglycans; Humans; M

2015
Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus.
    American journal of audiology, 2016, Sep-01, Volume: 25, Issue:3

    Topics: Central Nervous System Depressants; Cross-Sectional Studies; Dietary Supplements; Female; Flavonoids

2016
Glaucoma, "auditory glaucoma", "articular glaucoma" and the third eye.
    Medical hypotheses, 1980, Volume: 6, Issue:4

    Topics: Arthritis; Basement Membrane; Cell Membrane Permeability; Glaucoma; Humans; Lipid Metabolism; Melato

1980