Page last updated: 2024-10-19

melatonin and Sterility, Female

melatonin has been researched along with Sterility, Female in 31 studies

Research Excerpts

ExcerptRelevanceReference
"In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality."5.15Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. ( Buffo, S; Raffone, E; Rizzo, P; Unfer, V, 2011)
" The numbers of matured follicles and retrieved oocytes, fertilization rates, implantation rates, clinical pregnancy rate, and intrafollicular concentrations of TNFα, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL) as oxidative stress markers, and melatonin and Cu,Zu-superoxide dismutase (Cu,Zn-SOD) as antioxidants were compared between the two groups."3.80A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis. ( Nakamura, Y; Numa, F; Sugino, N; Takasaki, A; Tamura, H, 2014)
"The results showed that thiamine pyrophosphate prevented ischemia/reperfusion injury-related infertility, but melatonin did not provide adequate prevention."3.79Use of thiamine pyrophosphate to prevent infertility developing in rats undergoing unilateral ovariectomy and with ischemia reperfusion induced in the contralateral ovary. ( Borekci, B; Cetin, N; Gul, MA; Turan, MI; Yapca, OE, 2013)
" We present a proposal for a pilot double-blind randomised placebo-controlled dose-response trial aimed to determine whether oral melatonin supplementation during ovarian stimulation can improve the outcomes of assisted reproductive technology."2.79A pilot double-blind randomised placebo-controlled dose-response trial assessing the effects of melatonin on infertility treatment (MIART): study protocol. ( Fernando, S; Osianlis, T; Rombauts, L; Vollenhoven, B; Wallace, E, 2014)
"IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed."2.76Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. ( Aksakal, FN; Cicek, N; Devran, A; Eryilmaz, OG; Mollamahmutoğlu, L; Sarikaya, E, 2011)
"Melatonin has the potential to be used as a chemotherapeutic adjuvant to simultaneously improve the outcome of anti-cancer treatment and preserve ovarian function during cisplatin chemotherapy."1.62Melatonin provides protection against cisplatin-induced ovarian damage and loss of fertility in mice. ( Chen, G; Chen, J; Guo, E; Huang, J; Li, K; Li, N; Lu, H; Ma, D; Shan, W; Sun, C; Wang, B; Wu, Y; Xi, L; Xia, M; Zhou, B, 2021)
"Endometriosis is now considered to be a public health problem that deserves in-depth investigation, especially the etiopathogenesis of endometriosis-associated infertility."1.56Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility. ( Dai, Y; Huang, D; Huang, Q; Jin, X; Li, C; Lin, X; Tong, X; Xu, W; Zhang, S; Zhou, F; Zhou, H, 2020)
"Melatonin treatment delayed granulosa cell aging progression."1.56The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin. ( Gu, L; He, Q; Li, PA; Lin, Q; Liu, C; Ma, Y; Pei, X; Yang, Y, 2020)
"Melatonin levels were found to fluctuate during the menstrual cycle of these subjects with a nadir at mid-cycle and peak occurring at the early follicular/late luteal phases of the cycle (p < 0."1.30Plasma melatonin profile and hormonal interactions in the menstrual cycles of anovulatory infertile women treated with gonadotropins. ( Chan, TY; Pang, SF; Tang, GW; Tang, PL, 1998)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's5 (16.13)18.2507
2000's4 (12.90)29.6817
2010's11 (35.48)24.3611
2020's10 (32.26)2.80

Authors

AuthorsStudies
Yuzko, VO1
Yuzko, OM1
Yuzko, TA1
Pryimak, SH1
Voloshynovych, NS1
Chobaniuk, SI1
Aci, R1
Ciftci, G1
Yigit, S1
Sezer, O1
Keskin, A1
Latif Khan, H1
Bhatti, S1
Latif Khan, Y1
Abbas, S1
Munir, Z1
Rahman Khan Sherwani, IA1
Suhail, S1
Hassan, Z1
Aydin, HH1
Lin, X2
Dai, Y1
Tong, X1
Xu, W1
Huang, Q1
Jin, X1
Li, C1
Zhou, F1
Zhou, H1
Huang, D1
Zhang, S1
He, Q1
Gu, L1
Lin, Q1
Ma, Y1
Liu, C1
Pei, X1
Li, PA1
Yang, Y1
Huang, J1
Shan, W1
Li, N2
Zhou, B1
Guo, E1
Xia, M1
Lu, H1
Wu, Y1
Chen, J1
Wang, B1
Xi, L1
Ma, D1
Chen, G1
Li, K1
Sun, C1
Yang, L1
Xu, H1
Chen, Y1
Miao, C1
Zhao, Y1
Xing, Y1
Zhang, Q1
Ivanov, D1
Mazzoccoli, G1
Anderson, G1
Linkova, N1
Dyatlova, A1
Mironova, E1
Polyakova, V1
Kvetnoy, I1
Evsyukova, I1
Carbone, A1
Nasyrov, R1
Hansda, SR1
Haldar, C1
Jiang, Y1
Shi, H1
Liu, Y1
Zhao, S1
Zhao, H1
Showell, MG1
Mackenzie-Proctor, R1
Jordan, V1
Hodgson, R1
Farquhar, C1
Shi, L1
Bo, L1
Xu, Z1
Yapca, OE1
Turan, MI1
Cetin, N1
Borekci, B1
Gul, MA1
Ermolenko, KS2
Rapoport, SI2
Solov'eva, AV1
Nishihara, T1
Hashimoto, S1
Ito, K1
Nakaoka, Y1
Matsumoto, K1
Hosoi, Y1
Morimoto, Y1
Fernando, S1
Osianlis, T1
Vollenhoven, B1
Wallace, E1
Rombauts, L1
Tamura, H3
Takasaki, A2
Nakamura, Y2
Numa, F1
Sugino, N2
Pacchiarotti, A2
Carlomagno, G1
Antonini, G1
Radzinsky, VE1
Unfer, V1
Raffone, E1
Rizzo, P1
Buffo, S1
Eryilmaz, OG1
Devran, A1
Sarikaya, E1
Aksakal, FN1
Mollamahmutoğlu, L1
Cicek, N1
Wójtowicz, M1
Jakiel, G1
Lovely, LP1
Meyer, WR1
Ekstrom, RD1
Golden, RN1
Takayama, H1
Kato, H1
Miwa, I1
Taniguchi, K1
Maekawa, R1
Asada, H1
Taketani, T1
Matsuoka, A1
Yamagata, Y1
Shimamura, K1
Morioka, H1
Ishikawa, H1
Reiter, RJ1
Bals-Pratsch, M1
De Geyter, C1
Müller, T1
Frieling, U1
Lerchl, A1
Pirke, KM1
Hanker, JP1
Becker-Carus, C1
Nieschlag, E1
Tang, PL1
Chan, TY1
Tang, GW1
Pang, SF1
Partonen, T2
Silman, R1
Vaughan, MK1
O'Steen, WK1
Vaughan, GM1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of IVF Outcome and Endometrium Effect in Infertility Patients Between Diminished and Normal Ovarian Reserve After Melatonin Administration.[NCT03117725]100 participants (Anticipated)Interventional2017-05-12Enrolling by invitation
Myo-inositol for the Management of Poor Ovarian Responders: A Prospective Randomized Controlled Trial[NCT04273256]Phase 2/Phase 3226 participants (Anticipated)Interventional2020-02-11Recruiting
A Prospective, Randomized, Double Blind, Study on the Clinical Efficacy Myo-inositol Versus D-chiro-inositol in Women Undergoing in Vitro Fertilization Embryo Transfer.[NCT01338844]Phase 40 participants InterventionalCompleted
Sleep Length and Euploid Embryo Transfer Prospective Study[NCT06139757]150 participants (Anticipated)Observational2024-01-01Not yet recruiting
The Potential Effects of Inofolic Plus on Abnormal Ovarian Reserve Parameters in Subfertile Women[NCT01290432]15 participants (Actual)Interventional2011-02-28Completed
Effects of Myo-inositol Plus Melatonin in Perimenopausal Women[NCT01325389]0 participants InterventionalRecruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for melatonin and Sterility, Female

ArticleYear
Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression.
    International journal of molecular sciences, 2021, May-30, Volume: 22, Issue:11

    Topics: Animals; Embryo Implantation; Embryo, Mammalian; Embryonic Development; Female; Gene Expression Regu

2021
Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Animals; Female; Humans; Infertility, Female; Melatonin; Oxidative Stress; Polycystic Ovary Syndrome

2021
Inositol for subfertile women with polycystic ovary syndrome.
    The Cochrane database of systematic reviews, 2018, 12-20, Volume: 12

    Topics: Abortion, Spontaneous; Administration, Oral; Birth Rate; Clomiphene; Combined Modality Therapy; Fema

2018
Melatonin and hypothalamic-pituitary-gonadal axis.
    Current medicinal chemistry, 2013, Volume: 20, Issue:15

    Topics: Animals; Circadian Rhythm; Female; Gonads; Humans; Hypothalamus; Infertility, Female; Melatonin; Oxi

2013
[STATE-OF-THE-ART OF REALIZATION OF THE FERTILITY POTENTIAL IN THE WOMEN OF LATE REPRODUCTIVE AGE].
    Klinicheskaia meditsina, 2016, Volume: 94, Issue:1

    Topics: Age Factors; Female; Fertility; Fertilization in Vitro; Humans; Infertility, Female; Melatonin; Repr

2016
[Melatonin and its role in human reproduction].
    Ginekologia polska, 2002, Volume: 73, Issue:12

    Topics: Adult; Circadian Rhythm; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Human

2002
Melatonin and the human gonadotrophin-releasing hormone pulse generator.
    The Journal of endocrinology, 1991, Volume: 128, Issue:1

    Topics: Circadian Rhythm; Contraception; Female; Gonadotropin-Releasing Hormone; Humans; Infertility, Female

1991

Trials

6 trials available for melatonin and Sterility, Female

ArticleYear
Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2014, Volume: 30, Issue:5

    Topics: Administration, Oral; Adult; Female; Fertilization in Vitro; Humans; Infertility, Female; Male; Mela

2014
A pilot double-blind randomised placebo-controlled dose-response trial assessing the effects of melatonin on infertility treatment (MIART): study protocol.
    BMJ open, 2014, Sep-01, Volume: 4, Issue:8

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Antioxidants; Deoxyguanosine; Dietary Supplements; Double-Blind Method;

2014
Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2016, Volume: 32, Issue:1

    Topics: Adult; Antioxidants; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Embryo Tra

2016
Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:11

    Topics: Adult; Cohort Studies; Female; Fertilization in Vitro; Follicle Stimulating Hormone, Human; Humans;

2011
Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:11

    Topics: Adult; Cohort Studies; Female; Fertilization in Vitro; Follicle Stimulating Hormone, Human; Humans;

2011
Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:11

    Topics: Adult; Cohort Studies; Female; Fertilization in Vitro; Follicle Stimulating Hormone, Human; Humans;

2011
Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:11

    Topics: Adult; Cohort Studies; Female; Fertilization in Vitro; Follicle Stimulating Hormone, Human; Humans;

2011
Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.
    Journal of assisted reproduction and genetics, 2011, Volume: 28, Issue:9

    Topics: Central Nervous System Depressants; Embryo Transfer; Embryo, Mammalian; Female; Fertilization in Vit

2011
Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
    Journal of pineal research, 2008, Volume: 44, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Female; Fertilization in Vitro;

2008
Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
    Journal of pineal research, 2008, Volume: 44, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Female; Fertilization in Vitro;

2008
Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
    Journal of pineal research, 2008, Volume: 44, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Female; Fertilization in Vitro;

2008
Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
    Journal of pineal research, 2008, Volume: 44, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Female; Fertilization in Vitro;

2008

Other Studies

18 other studies available for melatonin and Sterility, Female

ArticleYear
Comparative characteristics of infertile women when applying melatonin in complex preparation for assisted reproductive technologies.
    Journal of medicine and life, 2022, Volume: 15, Issue:8

    Topics: Anti-Mullerian Hormone; Estradiol; Female; Follicle Stimulating Hormone; Humans; Infertility, Female

2022
Clock 3111 T/C and Period3 VNTR gene polymorphisms and proteins, and melatonin levels in women with infertility.
    Journal of assisted reproduction and genetics, 2023, Volume: 40, Issue:5

    Topics: CLOCK Proteins; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Infertility

2023
Cell-free nucleic acids and melatonin levels in human follicular fluid predict embryo quality in patients undergoing in-vitro fertilization treatment.
    Journal of gynecology obstetrics and human reproduction, 2020, Volume: 49, Issue:1

    Topics: Adult; Cell-Free Nucleic Acids; Chorionic Gonadotropin; DNA; DNA Copy Number Variations; DNA Fragmen

2020
Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility.
    Redox biology, 2020, Volume: 30

    Topics: Animals; Antigens, Neoplasm; Cell Line; Cellular Senescence; Cumulus Cells; Disease Models, Animal;

2020
The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
    Endocrinology, 2020, 09-01, Volume: 161, Issue:9

    Topics: Animals; Antioxidants; beta Catenin; Cells, Cultured; Cellular Senescence; Endopeptidases; Estrogens

2020
Melatonin provides protection against cisplatin-induced ovarian damage and loss of fertility in mice.
    Reproductive biomedicine online, 2021, Volume: 42, Issue:3

    Topics: Animals; Animals, Newborn; Antineoplastic Agents; Antioxidants; Cisplatin; Drug Evaluation, Preclini

2021
Melatonin: Multi-Target Mechanism Against Diminished Ovarian Reserve Based on Network Pharmacology.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Apoptosis; Cell Proliferation; Computational Biology; Databases, Protein; Endocrine System; Female;

2021
Uterine anomalies in cell proliferation, energy homeostasis and oxidative stress in PCOS hamsters, M. auratus: Therapeutic potentials of melatonin.
    Life sciences, 2021, Sep-15, Volume: 281

    Topics: Animals; Aromatase Inhibitors; Blood Glucose; Cell Proliferation; Cricetinae; Disease Models, Animal

2021
Use of thiamine pyrophosphate to prevent infertility developing in rats undergoing unilateral ovariectomy and with ischemia reperfusion induced in the contralateral ovary.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 170, Issue:2

    Topics: Animals; Antioxidants; Disease Models, Animal; Female; Infertility, Female; Melatonin; Ovarian Disea

2013
[Melatonin secretion in women of advanced reproductive age].
    Klinicheskaia meditsina, 2013, Volume: 91, Issue:7

    Topics: Adult; Age Factors; Female; Humans; Infertility, Female; Melatonin

2013
A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis.
    Journal of ovarian research, 2014, Oct-21, Volume: 7

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Deoxyguanosine; Endometriosis; Female; Fertilization

2014
Effect of stress on pregnancy outcome among women undergoing assisted reproduction procedures.
    Southern medical journal, 2003, Volume: 96, Issue:6

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Female; Humans; Hydrocortisone; Infertility, Female; Me

2003
Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production.
    Fertility and sterility, 2003, Volume: 80, Issue:4

    Topics: Cells, Cultured; Estradiol; Female; Follicular Fluid; Follicular Phase; Humans; Infertility, Female;

2003
Episodic variations of prolactin, thyroid-stimulating hormone, luteinizing hormone, melatonin and cortisol in infertile women with subclinical hypothyroidism.
    Human reproduction (Oxford, England), 1997, Volume: 12, Issue:5

    Topics: Adult; Circadian Rhythm; Dehydroepiandrosterone Sulfate; Estradiol; Female; Humans; Hydrocortisone;

1997
Plasma melatonin profile and hormonal interactions in the menstrual cycles of anovulatory infertile women treated with gonadotropins.
    Gynecologic and obstetric investigation, 1998, Volume: 45, Issue:4

    Topics: Adult; Anovulation; Chorionic Gonadotropin; Estradiol; Female; Follicle Stimulating Hormone; Follicu

1998
Melatonin-dependent infertility.
    Medical hypotheses, 1999, Volume: 52, Issue:3

    Topics: Animals; Circadian Rhythm; Female; Fertility; Humans; Infertility, Female; Infertility, Male; Light;

1999
Short note: melatonin-dependent infertility.
    Medical hypotheses, 1999, Volume: 52, Issue:5

    Topics: Female; Humans; Infertility, Female; Infertility, Male; Light; Male; Melatonin; Models, Biological;

1999
Estrous cycle changes after prenatal and neonatal injections of melatonin in normal and androgen-sterilized female rats.
    Neuroendocrinology, 1970, Volume: 6, Issue:1

    Topics: Animals; Animals, Newborn; Estrus; Female; Hypothalamus; Infertility, Female; Melatonin; Ovulation;

1970