melatonin has been researched along with Status Epilepticus in 9 studies
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study aimed to explore and compare the efficacy of chronic pretreatment with melatonin infused via subcutaneous osmotic mini-pumps for 14 days (10 mg/kg per day) on kainic acid (KA)-induced status epilepticus, oxidative stress and expression of heat shock protein (HSP) 72 in spontaneously hypertensive rats (SHRs) and normotensive Wistar rats." | 7.79 | Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins. ( Atanasova, M; Blazhev, A; Dragomirova, P; Pechlivanova, D; Petkova, Z; Tchekalarova, J, 2013) |
| "Melatonin treatment for 7 days showed a decrease in seizure intensity (28%), latency to reach score 5 (14 min), and duration of SE (29%)." | 5.72 | Melatonin Pretreatment Protects Against Status epilepticus, Glutamate Transport, and Oxidative Stress Induced by Kainic Acid in Zebrafish. ( Baldin, SL; Bernardo, HT; de Farias, ACS; de Pieri Pickler, K; Dondossola, ER; Rico, EP, 2022) |
| "Melatonin is a potent antioxidant which showed anticonvulsant activities both in experimental and clinical studies." | 5.39 | Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. ( Atanasova, D; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Moyanova, S; Pechlivanova, D; Petkova, Z; Stoynev, A; Tchekalarova, J, 2013) |
| " Last, CPEB4-deficient mice showed altered circadian function, including altered melatonin blood levels and altered clustering of spontaneous seizures during the day." | 4.31 | CPEB4-CLOCK crosstalk during temporal lobe epilepsy. ( Alves, M; Auer, T; Beausang, A; Brennan, GP; Brett, FM; Carracedo-Rodríguez, G; Cryan, J; de Diego-Garcia, L; Delanty, N; Engel, T; Farrell, MA; Gil, B; Henshall, DC; Lau, K; Lucas, JJ; Martin-Gil, A; Mendez, R; Menendez-Mendez, A; Mitra, M; O'Brien, DF; Ollà, I; Parras, A; Villalba-Benito, L, 2023) |
| "This is the first study to reveal the relationship between ESs and basal melatonin levels according to all the characteristics of seizure and epilepsy in the largest patient group." | 3.96 | The relationship between epileptic seizure and melatonin in children. ( Aksu Uzunhan, T; Kacar, A; Kucur, M; Saltik, S; Tarcin, G, 2020) |
| " The present study aimed to explore and compare the efficacy of chronic pretreatment with melatonin infused via subcutaneous osmotic mini-pumps for 14 days (10 mg/kg per day) on kainic acid (KA)-induced status epilepticus, oxidative stress and expression of heat shock protein (HSP) 72 in spontaneously hypertensive rats (SHRs) and normotensive Wistar rats." | 3.79 | Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins. ( Atanasova, M; Blazhev, A; Dragomirova, P; Pechlivanova, D; Petkova, Z; Tchekalarova, J, 2013) |
| "Melatonin was used as positive control while the melatonin receptor antagonist Luzindol was studied alone or in combination with melatonin or 3e, respectively." | 1.72 | The Anticonvulsant Effect of a Novel Indole-Related Compound in the Kainate-Induced Status Epilepticus in Mice: The Role of the Antioxidant and Anti-inflammatory Mechanism. ( Andreeva-Gateva, P; Angelova, V; Stoyanova, T; Tchekalarova, J; Tzoneva, R, 2022) |
| "Melatonin treatment for 7 days showed a decrease in seizure intensity (28%), latency to reach score 5 (14 min), and duration of SE (29%)." | 1.72 | Melatonin Pretreatment Protects Against Status epilepticus, Glutamate Transport, and Oxidative Stress Induced by Kainic Acid in Zebrafish. ( Baldin, SL; Bernardo, HT; de Farias, ACS; de Pieri Pickler, K; Dondossola, ER; Rico, EP, 2022) |
| "Melatonin is a potent antioxidant which showed anticonvulsant activities both in experimental and clinical studies." | 1.39 | Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. ( Atanasova, D; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Moyanova, S; Pechlivanova, D; Petkova, Z; Stoynev, A; Tchekalarova, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 5 (55.56) | 2.80 |
| Authors | Studies |
|---|---|
| Tchekalarova, J | 3 |
| Stoyanova, T | 1 |
| Tzoneva, R | 1 |
| Angelova, V | 1 |
| Andreeva-Gateva, P | 1 |
| de Farias, ACS | 1 |
| de Pieri Pickler, K | 1 |
| Bernardo, HT | 1 |
| Baldin, SL | 1 |
| Dondossola, ER | 1 |
| Rico, EP | 1 |
| Atacan Yaşgüçlükal, M | 1 |
| Ayça, S | 1 |
| Demirbilek, V | 1 |
| Saltık, S | 2 |
| Yalçınkaya, C | 1 |
| Erdoğan Döventaş, Y | 1 |
| Çokar, Ö | 1 |
| de Diego-Garcia, L | 1 |
| Brennan, GP | 1 |
| Auer, T | 1 |
| Menendez-Mendez, A | 1 |
| Parras, A | 1 |
| Martin-Gil, A | 1 |
| Mitra, M | 1 |
| Ollà, I | 1 |
| Villalba-Benito, L | 1 |
| Gil, B | 1 |
| Alves, M | 1 |
| Lau, K | 1 |
| Delanty, N | 1 |
| Beausang, A | 1 |
| Cryan, J | 1 |
| Brett, FM | 1 |
| Farrell, MA | 1 |
| O'Brien, DF | 1 |
| Mendez, R | 1 |
| Carracedo-Rodríguez, G | 1 |
| Henshall, DC | 1 |
| Lucas, JJ | 1 |
| Engel, T | 1 |
| Tarcin, G | 1 |
| Aksu Uzunhan, T | 1 |
| Kacar, A | 1 |
| Kucur, M | 1 |
| Petkova, Z | 2 |
| Pechlivanova, D | 2 |
| Moyanova, S | 1 |
| Kortenska, L | 1 |
| Mitreva, R | 1 |
| Lozanov, V | 1 |
| Atanasova, D | 1 |
| Lazarov, N | 1 |
| Stoynev, A | 1 |
| Atanasova, M | 1 |
| Dragomirova, P | 1 |
| Blazhev, A | 1 |
| Lima, E | 1 |
| Cabral, FR | 1 |
| Cavalheiro, EA | 1 |
| Naffah-Mazzacoratti, Mda G | 1 |
| Amado, D | 2 |
| de Lima, E | 1 |
| Soares, JM | 1 |
| del Carmen Sanabria Garrido, Y | 1 |
| Gomes Valente, S | 1 |
| Priel, MR | 1 |
| Chada Baracat, E | 1 |
| Abrão Cavalheiro, E | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for melatonin and Status Epilepticus
| Article | Year |
|---|---|
The Anticonvulsant Effect of a Novel Indole-Related Compound in the Kainate-Induced Status Epilepticus in Mice: The Role of the Antioxidant and Anti-inflammatory Mechanism.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Hippocampus; Kainic Acid; Melatoni | 2022 |
Melatonin Pretreatment Protects Against Status epilepticus, Glutamate Transport, and Oxidative Stress Induced by Kainic Acid in Zebrafish.
Topics: Amino Acid Transport System X-AG; Animals; Antioxidants; Catalase; Glutamic Acid; Glutathione; Kaini | 2022 |
Serum Levels of Neuropeptides in Epileptic Encephalopathy With Spike-and-Wave Activation in Sleep.
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy, Generali | 2023 |
CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
Topics: Animals; CLOCK Proteins; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Male | 2023 |
The relationship between epileptic seizure and melatonin in children.
Topics: Child; Electroencephalography; Epilepsy; Humans; Melatonin; Seizures; Status Epilepticus | 2020 |
Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Central Nervous System Depressants; Chromatography, High Pressure Liq | 2013 |
Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins.
Topics: Animals; Blotting, Western; Cytosol; Heat-Shock Proteins; Kainic Acid; Male; Melatonin; Mitochondria | 2013 |
Melatonin administration after pilocarpine-induced status epilepticus: a new way to prevent or attenuate postlesion epilepsy?
Topics: Analysis of Variance; Animals; Antioxidants; Cell Death; Disease Models, Animal; Hippocampus; Male; | 2011 |
Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Denervation; Disease Models, Animal; Epilepsy, Temporal Lobe; H | 2005 |