melatonin has been researched along with Spinal Cord Injuries in 65 studies
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the anti-edema effects of melatonin on spinal cord injury (SCI) in rats." | 7.81 | Anti-edema effect of melatonin on spinal cord injury in rats. ( Hou, M; Liu, X; Liu, Y; Wang, Y; Xiang, L; Yang, J; Zhou, D, 2015) |
| "By inhibiting neuroinflammation and reducing neuronal death, melatonin promotes the recovery of neuromotor function." | 4.12 | Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome. ( Dang, X; Dong, Q; Huang, H; Ma, D; Qu, Z; Wang, H, 2022) |
| "The aim of this study was to estimate the effect of melatonin on spinal cord perfusion, the permeability of blood-spinal cord barrier (BSCB), and edema at the contusion epicenter and regions rostral and caudal to the injury site in rats with spinal cord injury (SCI)." | 3.83 | Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry. ( Bai, F; Chen, H; Dong, H; Jing, Y, 2016) |
| "To determine the anti-edema effects of melatonin on spinal cord injury (SCI) in rats." | 3.81 | Anti-edema effect of melatonin on spinal cord injury in rats. ( Hou, M; Liu, X; Liu, Y; Wang, Y; Xiang, L; Yang, J; Zhou, D, 2015) |
| " Given that the antioxidant melatonin significantly decreased SCI-induced AQP-1 increases and that hypoxia inducible factor-1alpha was increased in acutely and chronically injured spinal cords, we propose that chronic hypoxia contributes to persistent AQP-1 increases after SCI." | 3.74 | Aquaporin 1 - a novel player in spinal cord injury. ( Hulsebosch, CE; Johnson, K; Lee, J; Nesic, O; Perez-Polo, JR; Unabia, GC; Vergara, L; Ye, Z, 2008) |
| " Methylprednisolone (MP), by reducing edema and protecting the cell membrane against peroxidation, is the only pharmacological agent with a proven clinically beneficial effect on SCI." | 3.72 | Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury. ( Batcioglu, K; Cayli, SR; Erbil, M; Kocak, A; Ozturk, C; Tekiner, A; Yilmaz, U; Yologlu, S, 2004) |
| "Melatonin has been shown to be a versatile hormone having antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties." | 2.50 | Role of melatonin in traumatic brain injury and spinal cord injury. ( Naseem, M; Parvez, S, 2014) |
| "Treatment with melatonin significantly alleviated neuronal apoptosis and accelerated the recovery of spinal cord function." | 1.62 | Role of melatonin in the dynamics of acute spinal cord injury in rats. ( Bi, J; Chen, C; Li, Z; Lin, Y; Shen, J; Sun, P; Tan, H, 2021) |
| "Melatonin treatment partially prevented these reductions." | 1.46 | Melatonin prevents blood vessel loss and neurological impairment induced by spinal cord injury in rats. ( Bai, F; Chen, H; Dong, H; Jing, Y, 2017) |
| "The melatonin-treated mice presented higher expression of neuronal markers (P < 0." | 1.43 | Effects of melatonin on severe crush spinal cord injury-induced reactive astrocyte and scar formation. ( Govitrapong, P; Jongkamonwiwat, N; Krityakiarana, W; Mukda, S; Phansuwan-Pujito, P; Pinilla, FG; Sompup, K, 2016) |
| "Recently, we reported that tetraplegia is associated with a blunted release of melatonin in the evening." | 1.40 | Within-subject correlations between evening-related changes in body temperature and melatonin in the spinal cord injured. ( Atkinson, G; Eijsvogels, TM; Groothuis, JT; Hopman, MT; Jones, H; Nyakayiru, J; Thijssen, DH; Thompson, A; Verheggen, RJ, 2014) |
| "Melatonin was administered twice a day and exercise was performed on a treadmill for 15 min, six days per week for 3 weeks after SCI." | 1.40 | Beneficial effects of melatonin combined with exercise on endogenous neural stem/progenitor cells proliferation after spinal cord injury. ( Chang, KT; Hong, Y; Jin, Y; Lee, M; Lee, S; Lee, SR; Lee, Y; Park, K; Park, S, 2014) |
| "Melatonin treatment following photochemically induced SCI in rats significantly ameliorated the functional deficits." | 1.40 | Melatonin improves functional outcome via inhibition of matrix metalloproteinases-9 after photothrombotic spinal cord injury in rats. ( Hur, H; Jang, JW; Kim, HS; Lee, JK; Lee, SS; Piao, MS; Xiao, L, 2014) |
| "Melatonin treatment improved locomotor functional outcome and rescued motor neurons." | 1.40 | Microvascular protective role of pericytes in melatonin-treated spinal cord injury in the C57BL/6 mice. ( Jing, Y; Li, B; Li, H; Liu, M; Liu, S; Wu, Q; Xiu, R; Yuan, X; Zhang, X, 2014) |
| "Melatonin was administred intraperitoneally at a dose of 10 mg/kg for seven days." | 1.39 | Protective effects of melatonin against spinal cord injury induced oxidative damage in rat kidney: A morphological and biochemical study. ( Akakin, D; Erşahin, M; Kiran, D; Ozdemir-Kumral, ZN; Ozkan, N; Sener, G; Yeğen, B, 2013) |
| "Melatonin (10 mg/kg) was injected subcutaneously for 4 wk, twice daily (07:00, 19:00)." | 1.38 | Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury. ( Chang, KT; Hong, Y; Jeon, JC; Kim, JH; Lee, S; Lee, SK; Lee, SR; Lee, Y; Park, K; Park, S, 2012) |
| " The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity." | 1.36 | Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury. ( Fee, DB; Gabbita, P; Roberts, K; Scheff, N; Scheff, S; Swartz, KR, 2010) |
| " Dosage was in accordance with their pharmacokinetic properties and experience gained with experimental SCI." | 1.35 | Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. ( Franco-Bourland, RE; Grijalva, I; Guízar-Sahagún, G; Ibarra, A; Madrazo, I; Martínez-Cruz, A; Rodríguez-Balderas, CA, 2009) |
| "Melatonin-treated animals had better neurologic function than those of the I/R group." | 1.35 | Effects of melatonin on ischemic spinal cord injury caused by aortic cross clamping in rabbits. ( Kardeş, O; Korkmaz, A; Omeroğlu, S; Oyar, EO, 2008) |
| "Melatonin was found to be superior to octreotide with respect to the prevention of congestion, edema, axonal degeneration and necrosis." | 1.35 | Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. ( Erol, FS; Ilhan, N; Kaplan, M; Ozercan, I; Tiftikci, M; Topsakal, C; Yakar, H, 2008) |
| "Melatonin (100 mg/kg) was given intraperitoneally immediately after trauma to the rats in the groups 3 and 6." | 1.34 | Does pinealectomy affect the recovery rate after spinal cord injury? ( Altinoz, E; Ates, O; Cayli, S; Gurses, I; Iraz, M; Kocak, A; Yologlu, S; Yucel, N, 2007) |
| "Melatonin-treated groups showed more ultrastructural improvement on electron microscope studies when compared with methylprednisone group." | 1.33 | Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats. ( Bilge, T; Celik, SE; Cokar, N; Gül, S; Kalayci, M; Taşyürekli, M, 2005) |
| "Melatonin has been found useful in spinal cord injury in previous studies." | 1.32 | Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury. ( Akdemir, I; Gursu, F; Kaplan, M; Kilic, N; Ozveren, F; Tiftikci, M; Topsakal, C, 2003) |
| "Melatonin was shown to play an important role in protecting animal cells from neutrophil-induced toxicity and damage by free radicals." | 1.31 | Potent protective effects of melatonin on experimental spinal cord injury. ( Fujimoto, T; Ikeda, T; Nakamura, T; Takagi, K, 2000) |
| "Melatonin production was absent in the three tetraplegic subjects with injury to their lower cervical spinal cord and was of normal amplitude and timing in the two paraplegic subjects with injury to their upper thoracic spinal cord." | 1.31 | Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia. ( Ayas, NT; Brown, R; Czeisler, CA; Shea, SA; Zeitzer, JM, 2000) |
| "Melatonin is a very effective antioxidant agent." | 1.31 | Comparison of the effects of melatonin and methylprednisolone in experimental spinal cord injury. ( Demirpençe, E; Kaptanoglu, E; Kilinç, K; Konan, A; Palaoglu, S; Tuncel, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.08) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (32.31) | 29.6817 |
| 2010's | 30 (46.15) | 24.3611 |
| 2020's | 12 (18.46) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Tang, P | 1 |
| Wang, J | 2 |
| Ye, W | 1 |
| Ge, X | 1 |
| Rong, Y | 1 |
| Ji, C | 1 |
| Wang, Z | 1 |
| Bai, J | 1 |
| Fan, J | 1 |
| Yin, G | 1 |
| Cai, W | 1 |
| Zhang, M | 1 |
| Bai, Y | 1 |
| Xu, C | 2 |
| Lin, J | 1 |
| Jin, J | 1 |
| Xu, A | 1 |
| Lou, JN | 1 |
| Qian, C | 1 |
| Yu, W | 1 |
| Wu, Y | 1 |
| Qi, Y | 1 |
| Tao, H | 1 |
| Wang, H | 3 |
| Huang, H | 1 |
| Qu, Z | 1 |
| Ma, D | 1 |
| Dang, X | 3 |
| Dong, Q | 1 |
| Naeimi, A | 3 |
| Zaminy, A | 3 |
| Amini, N | 3 |
| Balabandi, R | 3 |
| Golipoor, Z | 3 |
| Guo, Y | 3 |
| Zhang, P | 1 |
| Zhao, H | 1 |
| Lin, S | 1 |
| Mei, X | 2 |
| Tian, H | 2 |
| Zhong, G | 1 |
| Yang, Y | 1 |
| Feng, D | 1 |
| Wei, K | 1 |
| Chen, J | 2 |
| Deng, C | 1 |
| Yang, Z | 1 |
| Bao, Y | 1 |
| Chen, W | 1 |
| He, Y | 1 |
| Gao, K | 2 |
| Niu, J | 1 |
| Majidpoor, J | 1 |
| Mortezaee, K | 1 |
| Khezri, Z | 1 |
| Fathi, F | 1 |
| Zali, A | 1 |
| Derakhshan, HB | 1 |
| Bariki, MG | 1 |
| Joghataie, MT | 1 |
| Shirazi, R | 1 |
| Moradi, F | 1 |
| Fakhri, S | 1 |
| Kiani, A | 1 |
| Jalili, C | 1 |
| Abbaszadeh, F | 1 |
| Piri, S | 1 |
| Farzaei, MH | 1 |
| Rastegari-Pouyani, M | 1 |
| Mohammadi-Noori, E | 1 |
| Khan, H | 1 |
| Bi, J | 1 |
| Shen, J | 1 |
| Chen, C | 1 |
| Li, Z | 1 |
| Tan, H | 1 |
| Sun, P | 1 |
| Lin, Y | 1 |
| Shen, Z | 1 |
| Zhou, Z | 1 |
| Gao, S | 1 |
| Thøfner Hultén, VD | 1 |
| Biering-Sørensen, F | 1 |
| Jørgensen, NR | 1 |
| Jennum, PJ | 1 |
| Whelan, A | 1 |
| Halpine, M | 1 |
| Christie, SD | 1 |
| McVeigh, SA | 1 |
| Xu, G | 1 |
| Shi, D | 1 |
| Zhi, Z | 1 |
| Ao, R | 1 |
| Yu, B | 1 |
| Jing, Y | 5 |
| Yang, D | 1 |
| Bai, F | 3 |
| Zhang, C | 1 |
| Qin, C | 1 |
| Li, D | 1 |
| Wang, L | 1 |
| Yang, M | 1 |
| Chen, Z | 1 |
| Li, J | 1 |
| Zhang, Y | 2 |
| Liu, Z | 1 |
| Zhang, W | 2 |
| Wu, Q | 3 |
| Liu, Y | 2 |
| Guan, Y | 1 |
| Chen, X | 1 |
| Li, Y | 2 |
| Fan, Y | 1 |
| Li, K | 1 |
| Akakin, D | 2 |
| Kiran, D | 1 |
| Ozkan, N | 1 |
| Erşahin, M | 3 |
| Ozdemir-Kumral, ZN | 1 |
| Yeğen, B | 1 |
| Sener, G | 3 |
| Jones, H | 1 |
| Eijsvogels, TM | 1 |
| Nyakayiru, J | 1 |
| Verheggen, RJ | 1 |
| Thompson, A | 1 |
| Groothuis, JT | 1 |
| Atkinson, G | 1 |
| Hopman, MT | 1 |
| Thijssen, DH | 1 |
| Lee, Y | 3 |
| Lee, S | 3 |
| Lee, SR | 2 |
| Park, K | 4 |
| Hong, Y | 7 |
| Lee, M | 1 |
| Park, S | 4 |
| Jin, Y | 1 |
| Chang, KT | 3 |
| Tavukçu, HH | 1 |
| Sener, TE | 1 |
| Tinay, I | 1 |
| Akbal, C | 1 |
| Cevik, O | 1 |
| Cadirci, S | 1 |
| Reiter, RJ | 4 |
| Piao, MS | 1 |
| Lee, JK | 1 |
| Jang, JW | 1 |
| Hur, H | 1 |
| Lee, SS | 1 |
| Xiao, L | 1 |
| Kim, HS | 1 |
| Yuan, X | 2 |
| Li, B | 2 |
| Liu, M | 2 |
| Zhang, X | 2 |
| Liu, S | 2 |
| Li, H | 2 |
| Xiu, R | 2 |
| Wang, B | 1 |
| Naseem, M | 1 |
| Parvez, S | 1 |
| Kostovski, E | 1 |
| Dahm, AE | 1 |
| Mowinckel, MC | 1 |
| Stranda, A | 1 |
| Skretting, G | 1 |
| Østerud, B | 1 |
| Sandset, PM | 2 |
| Iversen, PO | 2 |
| Liu, X | 1 |
| Wang, Y | 1 |
| Yang, J | 1 |
| Zhou, D | 1 |
| Hou, M | 1 |
| Xiang, L | 1 |
| Yang, L | 1 |
| Yao, M | 1 |
| Lan, Y | 1 |
| Mo, W | 1 |
| Sun, YL | 1 |
| Wang, YJ | 1 |
| Cui, XJ | 1 |
| Fatima, G | 1 |
| Sharma, VP | 1 |
| Verma, NS | 1 |
| Gao, Y | 1 |
| Bai, C | 1 |
| Zheng, D | 1 |
| Li, C | 1 |
| Li, M | 1 |
| Guan, W | 1 |
| Ma, Y | 1 |
| Yuan, XC | 1 |
| Wang, P | 1 |
| Li, HW | 1 |
| Wu, QB | 1 |
| Zhang, XY | 1 |
| Li, BW | 1 |
| Xiu, RJ | 1 |
| Chen, H | 2 |
| Dong, H | 2 |
| Paterniti, I | 1 |
| Campolo, M | 1 |
| Cordaro, M | 1 |
| Impellizzeri, D | 1 |
| Siracusa, R | 1 |
| Crupi, R | 1 |
| Esposito, E | 4 |
| Cuzzocrea, S | 5 |
| Krityakiarana, W | 1 |
| Sompup, K | 1 |
| Jongkamonwiwat, N | 1 |
| Mukda, S | 1 |
| Pinilla, FG | 1 |
| Govitrapong, P | 1 |
| Phansuwan-Pujito, P | 1 |
| Guízar-Sahagún, G | 1 |
| Rodríguez-Balderas, CA | 1 |
| Franco-Bourland, RE | 1 |
| Martínez-Cruz, A | 1 |
| Grijalva, I | 1 |
| Ibarra, A | 1 |
| Madrazo, I | 1 |
| Genovese, T | 4 |
| Caminiti, R | 2 |
| Bramanti, P | 4 |
| Meli, R | 2 |
| Gezici, AR | 1 |
| Karakaş, A | 1 |
| Ergün, R | 1 |
| Gündüz, B | 1 |
| Kil Lee, S | 1 |
| Fee, DB | 1 |
| Swartz, KR | 1 |
| Scheff, N | 1 |
| Roberts, K | 1 |
| Gabbita, P | 1 |
| Scheff, S | 1 |
| Palaksha, KJ | 1 |
| Kim, HD | 1 |
| Lee, SK | 1 |
| Jeon, JC | 1 |
| Kim, JH | 1 |
| Özdemir, Z | 1 |
| Özsavcı, D | 1 |
| Yeğen, BÇ | 1 |
| Topsakal, C | 2 |
| Kilic, N | 1 |
| Ozveren, F | 1 |
| Akdemir, I | 1 |
| Kaplan, M | 2 |
| Tiftikci, M | 2 |
| Gursu, F | 1 |
| Liu, JB | 1 |
| Tang, TS | 1 |
| Yang, HL | 1 |
| Xiao, DS | 1 |
| Tu, Y | 1 |
| Sun, RQ | 1 |
| Willis, WD | 1 |
| Cayli, SR | 1 |
| Kocak, A | 2 |
| Yilmaz, U | 1 |
| Tekiner, A | 1 |
| Erbil, M | 1 |
| Ozturk, C | 1 |
| Batcioglu, K | 1 |
| Yologlu, S | 2 |
| Mazzon, E | 2 |
| Muià, C | 2 |
| De Sarro, A | 1 |
| Zeitzer, JM | 3 |
| Ayas, NT | 3 |
| Wu, AD | 1 |
| Czeisler, CA | 3 |
| Brown, R | 3 |
| Scheer, FA | 1 |
| Shea, SA | 2 |
| Gül, S | 1 |
| Celik, SE | 1 |
| Kalayci, M | 1 |
| Taşyürekli, M | 1 |
| Cokar, N | 1 |
| Bilge, T | 1 |
| Dahm, A | 1 |
| Osterud, B | 1 |
| Hjeltnes, N | 1 |
| Ates, O | 1 |
| Cayli, S | 1 |
| Gurses, I | 1 |
| Yucel, N | 1 |
| Altinoz, E | 1 |
| Iraz, M | 1 |
| Crisafulli, C | 1 |
| Di Paola, R | 1 |
| Di Bella, P | 1 |
| Samantaray, S | 1 |
| Sribnick, EA | 1 |
| Das, A | 1 |
| Knaryan, VH | 1 |
| Matzelle, DD | 1 |
| Yallapragada, AV | 1 |
| Ray, SK | 1 |
| Banik, NL | 1 |
| Nesic, O | 1 |
| Lee, J | 1 |
| Unabia, GC | 1 |
| Johnson, K | 1 |
| Ye, Z | 1 |
| Vergara, L | 1 |
| Hulsebosch, CE | 1 |
| Perez-Polo, JR | 1 |
| Korkmaz, A | 1 |
| Oyar, EO | 1 |
| Kardeş, O | 1 |
| Omeroğlu, S | 1 |
| Erol, FS | 1 |
| Yakar, H | 1 |
| Ozercan, I | 1 |
| Ilhan, N | 1 |
| Fujimoto, T | 1 |
| Nakamura, T | 1 |
| Ikeda, T | 1 |
| Takagi, K | 1 |
| Kaptanoglu, E | 1 |
| Tuncel, M | 1 |
| Palaoglu, S | 1 |
| Konan, A | 1 |
| Demirpençe, E | 1 |
| Kilinç, K | 1 |
| Kneisley, LW | 1 |
| Moskowitz, MA | 1 |
| Lynch, HG | 1 |
| Jiang, DH | 1 |
| Wang, ML | 1 |
| Jiao, DR | 1 |
| Pang, SF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Restoration of Sleep in Heart Failure Patients[NCT00869869] | Phase 2 | 0 participants (Actual) | Interventional | 2009-03-31 | Withdrawn (stopped due to No subjects were enrolled in this study. Funding ran out.) | ||
| The Role of Melatonin in the Regulation of Blood Coagulation[NCT01741389] | Phase 1 | 12 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432] | Phase 2 | 40 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for melatonin and Spinal Cord Injuries
| Article | Year |
|---|---|
Systematic review of melatonin levels in individuals with complete cervical spinal cord injury.
Topics: Adult; Cervical Cord; Circadian Rhythm; Humans; Melatonin; Spinal Cord Injuries | 2020 |
Role of melatonin in traumatic brain injury and spinal cord injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Humans; Melatonin; Neuroprotective Agents; Oxidativ | 2014 |
Melatonin for Spinal Cord Injury in Animal Models: A Systematic Review and Network Meta-Analysis.
Topics: Animals; Antioxidants; Disease Models, Animal; Melatonin; Rats; Spinal Cord Injuries | 2016 |
Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury.
Topics: Central Nervous System Depressants; Exercise Therapy; Humans; Melatonin; Spinal Cord Injuries | 2010 |
1 trial available for melatonin and Spinal Cord Injuries
| Article | Year |
|---|---|
Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin.
Topics: Adult; Central Nervous System Agents; Cervical Cord; Circadian Rhythm; Cross-Over Studies; Double-Bl | 2015 |
60 other studies available for melatonin and Spinal Cord Injuries
| Article | Year |
|---|---|
Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Extracellular Vesicles; Lung Neoplasms; Melatonin; Mesenchy | 2021 |
Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats.
Topics: Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Liberation; Hydrogel | 2021 |
Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome.
Topics: Animals; Antioxidants; DNA Nucleotidylexotransferase; Glutathione Peroxidase; Inflammasomes; Inflamm | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley | 2022 |
Melatonin promotes microglia toward anti-inflammatory phenotype after spinal cord injury.
Topics: Anti-Inflammatory Agents; Humans; Melatonin; Microglia; Phenotype; Spinal Cord; Spinal Cord Injuries | 2023 |
Melatonin Protects Injured Spinal Cord Neurons From Apoptosis by Inhibiting Mitochondrial Damage via the SIRT1/Drp1 Signaling Pathway.
Topics: Animals; Apoptosis; Dynamins; Inflammation; Melatonin; Mice; Neurons; Rats; Rats, Sprague-Dawley; Si | 2023 |
Melatonin exerts neuroprotective effects by attenuating astro- and microgliosis and suppressing inflammatory response following spinal cord injury.
Topics: Animals; Astrocytes; Disease Models, Animal; Inflammation; Male; Melatonin; Mice, Inbred C57BL; Micr | 2020 |
Neuroprotection of melatonin on spinal cord injury by activating autophagy and inhibiting apoptosis via SIRT1/AMPK signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Male; Melatonin; Neuroprotective Agent | 2020 |
The effect of the "segment" of spinal cord injury on the activity of the nucleotide-binding domain-like receptor protein 3 inflammasome and response to hormonal therapy.
Topics: Animals; CARD Signaling Adaptor Proteins; Caspase 1; Disease Models, Animal; Down-Regulation; Drug A | 2021 |
Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Melatonin; Neuralgia; Neuroinflammatory Diseases; Rats; Rats, Sprag | 2021 |
Role of melatonin in the dynamics of acute spinal cord injury in rats.
Topics: Animals; Apoptosis; Biomarkers; Disease Models, Animal; Disease Susceptibility; Gene Expression; Imm | 2021 |
Melatonin Inhibits Neural Cell Apoptosis and Promotes Locomotor Recovery via Activation of the Wnt/β-Catenin Signaling Pathway After Spinal Cord Injury.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; | 2017 |
Melatonin and cortisol in individuals with spinal cord injury.
Topics: Adult; Cervical Vertebrae; Circadian Rhythm; Female; Humans; Hydrocortisone; Male; Melatonin; Middle | 2018 |
Melatonin ameliorates spinal cord injury by suppressing the activation of inflammasomes in rats.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Caspase 1; Cell Line, Tumor; Humans; Inflammasomes; Interle | 2019 |
Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice.
Topics: Animals; Dysbiosis; Female; Gastrointestinal Microbiome; Melatonin; Mice; Mice, Inbred C57BL; Neurop | 2019 |
Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages.
Topics: Animals; Apoptosis; Female; Interleukin-1beta; Macrophages; Melatonin; Microglia; Nitric Oxide Synth | 2019 |
Melatonin Enhances Autophagy and Reduces Apoptosis to Promote Locomotor Recovery in Spinal Cord Injury via the PI3K/AKT/mTOR Signaling Pathway.
Topics: Animals; Apoptosis; Autophagy; Locomotion; Male; Melatonin; Neurons; Neuroprotective Agents; Phospha | 2019 |
Protective effects of melatonin against spinal cord injury induced oxidative damage in rat kidney: A morphological and biochemical study.
Topics: Animals; Kidney; Male; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Spinal Cord Injuries | 2013 |
Within-subject correlations between evening-related changes in body temperature and melatonin in the spinal cord injured.
Topics: Adult; Body Temperature Regulation; Case-Control Studies; Circadian Rhythm; Cross-Sectional Studies; | 2014 |
Beneficial effects of melatonin combined with exercise on endogenous neural stem/progenitor cells proliferation after spinal cord injury.
Topics: Animals; Cell Proliferation; Exercise Therapy; Immunohistochemistry; Male; Melatonin; Motor Activity | 2014 |
Melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats.
Topics: Animals; Antioxidants; Carbolines; Erectile Dysfunction; Gene Expression Regulation, Enzymologic; Gl | 2014 |
Melatonin improves functional outcome via inhibition of matrix metalloproteinases-9 after photothrombotic spinal cord injury in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Matrix Metalloproteinase 2; Matrix Metallopro | 2014 |
Microvascular protective role of pericytes in melatonin-treated spinal cord injury in the C57BL/6 mice.
Topics: Angiopoietin-1; Animals; Enzyme-Linked Immunosorbent Assay; Intercellular Adhesion Molecule-1; Male; | 2014 |
Melatonin treatment protects against acute spinal cord injury-induced disruption of blood spinal cord barrier in mice.
Topics: Animals; Aquaporin 4; Capillary Permeability; Endothelium, Vascular; Hypoxia-Inducible Factor 1, alp | 2014 |
Anti-edema effect of melatonin on spinal cord injury in rats.
Topics: Animals; Antioxidants; Aquaporin 4; Body Water; Down-Regulation; Edema; Glial Fibrillary Acidic Prot | 2015 |
Circadian variations in melatonin and cortisol in patients with cervical spinal cord injury.
Topics: Adult; Cervical Cord; Circadian Rhythm; Female; Humans; Hydrocortisone; Male; Melatonin; Middle Aged | 2016 |
Combination of melatonin and Wnt-4 promotes neural cell differentiation in bovine amniotic epithelial cells and recovery from spinal cord injury.
Topics: Amnion; Animals; Cattle; Cell Differentiation; Epithelial Cells; Gene Expression Regulation; Melaton | 2016 |
Effects of melatonin on spinal cord injury-induced oxidative damage in mice testis.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Disease Models, Animal; Glutathione; Glutathio | 2017 |
Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Disease Models, Animal; Edema; Female; Laser-Doppler Flo | 2016 |
PPAR-α Modulates the Anti-Inflammatory Effect of Melatonin in the Secondary Events of Spinal Cord Injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Inflammation; Melatonin; Mice, | 2017 |
Effects of melatonin on severe crush spinal cord injury-induced reactive astrocyte and scar formation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Behavior, Animal; Cicatrix; Female; Lo | 2016 |
Melatonin prevents blood vessel loss and neurological impairment induced by spinal cord injury in rats.
Topics: Animals; Antigens, Nuclear; Blood Vessels; Brain-Derived Neurotrophic Factor; Female; GAP-43 Protein | 2017 |
Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions.
Topics: Analysis of Variance; Animals; Cyclosporine; Disease Models, Animal; Erythropoietin; Female; Locomot | 2009 |
Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury.
Topics: Analysis of Variance; Animals; HMGB1 Protein; Interleukin-1beta; MAP Kinase Signaling System; Melato | 2009 |
Rhythms of serum melatonin in rats with acute spinal cord injury at the cervical and thoracic regions.
Topics: Analysis of Variance; Animals; Blood Pressure; Cervical Vertebrae; Disease Models, Animal; Enzyme-Li | 2010 |
Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model.
Topics: Analysis of Variance; Animals; Blotting, Western; Body Weight; Disease Models, Animal; Drug Synergis | 2010 |
Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mela | 2010 |
Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury.
Topics: Analysis of Variance; Animals; Autophagy; Blotting, Western; Body Weight; Disease Models, Animal; Ma | 2012 |
Melatonin treatment protects against spinal cord injury induced functional and biochemical changes in rat urinary bladder.
Topics: Animals; Caspase 3; Glutathione; Malondialdehyde; Melatonin; Rats; Rats, Wistar; Spinal Cord Injurie | 2012 |
Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury.
Topics: Acute Disease; Alprostadil; Animals; Antioxidants; Aryldialkylphosphatase; Biomarkers; Disease Model | 2003 |
Antioxidation of melatonin against spinal cord injury in rats.
Topics: Animals; Antioxidants; Iron; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Rats; Rats, Sprag | 2004 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interac | 2004 |
Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury.
Topics: Animals; Axons; Disease Models, Animal; Drug Therapy, Combination; Edema; Evoked Potentials, Motor; | 2004 |
Attenuation in the evolution of experimental spinal cord trauma by treatment with melatonin.
Topics: Animals; Apoptosis; DNA; Enzyme Activation; Free Radical Scavengers; I-kappa B Proteins; Lipid Perox | 2005 |
Bilateral oculosympathetic paresis associated with loss of nocturnal melatonin secretion in patients with spinal cord injury.
Topics: Adult; Cervical Vertebrae; Circadian Rhythm; Horner Syndrome; Humans; Male; Melatonin; Pupil; Spinal | 2005 |
Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion.
Topics: Adolescent; Adult; Case-Control Studies; Cervical Vertebrae; Child; Child, Preschool; Female; Humans | 2006 |
Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Axons; Cytoprotection; Disease Models, Animal; Dose-Response Rela | 2005 |
Opposite circadian rhythms in melatonin and tissue factor pathway inhibitor type 1: does daylight affect coagulation?
Topics: Blood Coagulation; Circadian Rhythm; Endothelium, Vascular; Hemostasis; Humans; Light; Lipoproteins; | 2006 |
Does pinealectomy affect the recovery rate after spinal cord injury?
Topics: Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Gene Expression Regulation; Glutath | 2007 |
Effects of combination of melatonin and dexamethasone on secondary injury in an experimental mice model of spinal cord trauma.
Topics: Animals; Dexamethasone; Disease Models, Animal; Fas Ligand Protein; Immunohistochemistry; Melatonin; | 2007 |
Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats.
Topics: Animals; Apoptosis; Axons; Calcium; Calpain; Caspase 3; Central Nervous System Depressants; Gene Exp | 2008 |
Aquaporin 1 - a novel player in spinal cord injury.
Topics: Afferent Pathways; Animals; Antioxidants; Aquaporin 1; Astrocytes; Cell Size; Chronic Disease; Disea | 2008 |
Effects of melatonin on ischemic spinal cord injury caused by aortic cross clamping in rabbits.
Topics: Animals; Antioxidants; Aorta, Abdominal; Constriction; Disease Models, Animal; Glutathione; Male; Ma | 2008 |
Melatonin regulates matrix metalloproteinases after traumatic experimental spinal cord injury.
Topics: Animals; Blotting, Western; Central Nervous System Depressants; Lipid Peroxidation; Matrix Metallopr | 2008 |
Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration | 2008 |
Potent protective effects of melatonin on experimental spinal cord injury.
Topics: Animals; Leukopenia; Lipid Peroxidation; Locomotion; Male; Mechlorethamine; Melatonin; Peroxidase; R | 2000 |
Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia.
Topics: Adult; Cervical Vertebrae; Circadian Rhythm; Humans; Hydrocortisone; Male; Melatonin; Paraplegia; Qu | 2000 |
Comparison of the effects of melatonin and methylprednisolone in experimental spinal cord injury.
Topics: Analysis of Variance; Animals; Antioxidants; Axons; Cell Nucleus; Injections, Intraperitoneal; Lipid | 2000 |
Cervical spinal cord lesions disrupt the rhythm in human melatonin excretion.
Topics: Adult; Aldosterone; Circadian Rhythm; Growth Hormone; Humans; Hydrocortisone; Male; Melatonin; Parap | 1978 |
Rhythms of serum melatonin in patients with spinal lesions at the cervical, thoracic or lumbar region.
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Neural Pathways; Spinal Cord Injuries | 1989 |