melatonin has been researched along with Sleep Wake Disorders in 733 studies
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous study showed that both melatonin supplement and physical exercise intervention could improve sleep quality in children with autism spectrum disorders (ASD) with the increase in endogenous melatonin level." | 9.51 | Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders. ( Cheng, JCH; Ho, AWY; Lai, EWH; Lau, EYY; Lee, PH; Tse, ACY, 2022) |
| " We will include randomised clinical trials comparing melatonin versus placebo or no intervention for sleep disorders in children with neurodevelopmental disorders." | 9.51 | Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. ( Faltermeier, P; Gluud, C; Hermann, R; Horowitz, M; Jakobsen, JC; Juul, S; Jørgensen, CK; Moncrieff, J, 2022) |
| "Robust clinical evidence has not been available for melatonin, a drug commonly administered for treating sleep problems of children with autism spectrum disorder (ASD)." | 9.51 | Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial. ( Fukumizu, M; Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O, 2022) |
| "This study aimed to evaluate the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD)." | 9.41 | Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. ( He, R; Li, F; Li, W; Liu, Z; Shen, H; Wei, L; Xie, X; Xiong, M, 2023) |
| "Clinical evidence is required about the long-term efficacy and safety of melatonin treatment for sleep problems in children with neurodevelopmental disorders (NDDs) who underwent adequate sleep hygiene interventions." | 9.34 | Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders. ( Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Nagamitsu, S; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O; Yuge, K, 2020) |
| "Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD)." | 9.16 | Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. ( Adkins, KW; Burnette, C; Fawkes, D; Goldman, SE; Malow, B; McGrew, SG; Wang, L, 2012) |
| " The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in patients with depressive state after cerebral infarction." | 9.16 | A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. ( Katayama, Y; Katsura, K; Nishiyama, Y; Otori, T; Sunami, E; Usuda, K, 2012) |
| "To determine the efficacy of melatonin on sleep problems in children with autistic spectrum disorder (ASD) and fragile X syndrome (FXS)." | 9.14 | The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. ( Anders, TF; Bacalman, S; Diaz, R; Goodlin-Jones, BL; Hagerman, RJ; Jacquemont, S; Wirojanan, J, 2009) |
| "To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time)." | 9.11 | Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin. ( English, J; Hancock, E; O'Callaghan, F; Osborne, JP, 2005) |
| "We report a randomized, double-blind, controlled, crossover trial investigating the response to oral melatonin using two dose regimens in patients with sleep disorders associated with tuberous sclerosis complex." | 9.11 | Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. ( Hancock, E; O'Callaghan, F; Osborne, JP, 2005) |
| "Compared with placebo, melatonin taken for two weeks significantly decreased mean abdominal pain score (2." | 9.11 | Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. ( Gwee, KA; Ho, KY; Leng, PH; Moochhala, SM; Song, GH, 2005) |
| "To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS)." | 9.11 | Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. ( Gwee, KA; Ho, KY; Lu, WZ; Moochhalla, S, 2005) |
| "Forty-four participants with DSM-IV diagnoses of dementia with sleep disturbance were selected for a seven week randomised double blind cross over trial of slow release melatonin 6 mg versus placebo." | 9.10 | Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. ( Blizard, R; Kennell-Webb, S; Raven, P; Serfaty, M; Warner, J, 2002) |
| "The results of a therapeutic trial of the use of melatonin in patients with tuberous sclerosis complex who also have severe sleep problems are reported." | 9.09 | Use of melatonin to treat sleep disorders in tuberous sclerosis. ( Clarke, AA; Hancock, E; Hunt, A; O'Callaghan, FJ; Osborne, JP, 1999) |
| "We studied the usefulness of melatonin for sleep disorders and emotional/behavior disturbances of patients with developmental disorders." | 9.09 | [Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. ( Ishizaki, A; Sugama, M; Takeuchi, N, 1999) |
| "The aim of the study was to determine the possible effect of melatonin treatment on disturbed sleep, fatigue and pain symptoms observed in fibromyalgia (FM) patients." | 9.09 | The effect of melatonin in patients with fibromyalgia: a pilot study. ( Arias, MA; Brusco, LI; Cardinalli, DP; Citera, G; Lázaro, MA; Maldonado-Cocco, JA; Rosemffet, MG; Scheines, EJ, 2000) |
| "This study explored the safety and efficacy of synthetic melatonin in the treatment of sleep problems in 20 children with developmental disabilities, in a randomized, double-blind, placebo-controlled 6-week trial of melatonin versus placebo." | 9.09 | Melatonin for treatment of sleep disorders in children with developmental disabilities. ( Dodge, NN; Wilson, GA, 2001) |
| "Five patients with rapid-cycling DSM-III-R bipolar disorder were treated with melatonin 10 mg q." | 9.08 | Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. ( Feldman-Naim, S; Leibenluft, E; Rosenthal, NE; Turner, EH; Wehr, TA, 1997) |
| "Evaluate melatonin as a treatment for subjective tinnitus." | 9.08 | Effect of melatonin on tinnitus. ( Olds, MJ; Rosenberg, SI; Rowan, PT; Silverstein, H, 1998) |
| "The occurrence of headache and its change after treatment with melatonin 5 mg were studied in 30 patients with delayed sleep phase syndrome." | 9.08 | Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. ( Kerkhof, GA; Nagtegaal, JE; Smits, MG; Swart, AC; van der Meer, YG, 1998) |
| "The authors' goal was to examine the hypnotic effects of slow-release melatonin during the initial 4 weeks of treatment with fluoxetine in 19 patients with major depressive disorder." | 9.08 | Melatonin for the treatment of sleep disturbances in major depressive disorder. ( Dolberg, OT; Grunhaus, L; Hirschmann, S, 1998) |
| "In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study." | 9.04 | Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976) |
| "To investigate the efficacy of exogenous administration of melatonin and melatonin receptor agonists for the improvement of delirium, sleep, and other clinical outcomes of subjects in the intensive care unit (ICU)." | 9.01 | Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. ( Gao, F; Li, Z; Sun, W; Zhang, Q; Zhang, S, 2019) |
| "To determine the efficacy and safety of melatonin as therapy for sleep problems in children with neurodevelopmental disorders." | 8.98 | Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis. ( Abdelgadir, IS; Akobeng, AK; Gordon, MA, 2018) |
| "The current review aims to examine melatonin therapy for both sleep disturbances and cognitive function in dementia." | 8.91 | Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials. ( Chen, SD; Dammer, EB; Li, CB; Wang, G; Wang, LL; Xu, G; Xu, J, 2015) |
| "Melatonin is commonly recommended to treat sleep problems in children with developmental disabilities." | 8.91 | Melatonin Treatment in Children with Developmental Disabilities. ( Malow, BA; Schwichtenberg, AJ, 2015) |
| "Evidence from observational studies on light at night (LAN) exposure, sleep duration, endogenous melatonin levels, and risk for breast cancer in women is conflicting." | 8.90 | Light exposure at night, sleep duration, melatonin, and breast cancer: a dose-response analysis of observational studies. ( Deng, Q; Fan, WY; Wang, WY; Wang, X; Yang, WS, 2014) |
| "The screening of the literature was examined using the key words: burn patients, lymphocytopenia, skin oxidative stress, antioxidant, melatonin, and free radicals." | 8.84 | Melatonin as pharmacologic support in burn patients: a proposed solution to thermal injury-related lymphocytopenia and oxidative damage. ( Calvo, JR; Guerrero, JM; Lardone, PJ; Maldonado, MD; Murillo-Cabezas, F; Reiter, RJ; Tan, DX, 2007) |
| " Melatonin, the hormone of the pineal gland, received recently a great deal of attention because of its suggested role in aging processes and availability as over-the-counter drug or food supplement in some countries, including Poland." | 8.84 | Does melatonin play a role in aging processes? ( Karasek, M, 2007) |
| "Poor sleep quality is a major problem in patients with autism spectrum disorder (ASD), and is attributed to low melatonin levels." | 8.12 | Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study. ( Abraham, SJ; Balamurugan, M; Dedeepiya, VD; Ikewaki, N; Iwasaki, M; Kandaswamy, RS; Kurosawa, G; Preethy, S; Raghavan, K; Sonoda, T, 2022) |
| "Melatonin promptly reversed ischemia-induced sleep disturbances." | 8.02 | Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats. ( Hao, SM; Huang, ZL; Qiu, MH; Qu, WM; Sun, FY; Zhong, ZG, 2021) |
| "Melatonin is accessed by almost one quarter of children on the autism spectrum in New Zealand, with higher observed rates among females and those aged between 5 and 11 years, of European ethnicity, and presenting with co-occurring mental health conditions." | 8.02 | Melatonin dispensing among New Zealand children aged 0-18 years with autism: a nationwide cross-sectional study. ( Bowden, N; Eggleston, MJF; McLay, LK; Schluter, PJ; Woodford, EC, 2021) |
| "Although children with persistent post-concussion symptoms reported more SRPs, this was not related to actigraphy sleep parameters or melatonin production." | 7.96 | Sleep Parameters and Overnight Urinary Melatonin Production in Children With Persistent Post-concussion Symptoms. ( Barlow, KM; Crowe, EG; Dewey, D; Esser, MJ; Girgulis, KA; Goldstein, G; Kirk, VG; Su, P; Vo, MK, 2020) |
| "Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with sleep disturbances that may result from abnormalities in melatonin production." | 7.91 | Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder. ( Babinska, K; Bartakovicova, K; Celusakova, H; Kemenyova, P; Siklenkova, L; Stebelova, K; Szapuova, Z; Vidosovicova, M; Waczulikova, I, 2019) |
| "This prospective cohort study captured the patterns of sleep, sleep-wake activity rhythm, and first-morning urinary melatonin in breast cancer patients undergoing adjuvant chemotherapy." | 7.91 | Disruption of sleep, sleep-wake activity rhythm, and nocturnal melatonin production in breast cancer patients undergoing adjuvant chemotherapy: prospective cohort study. ( Chan, DC; Ho, AW; Ho, CS; Kwok, CC; Li, W; Tse, LA; Wang, F; Wing, YK; Zhang, J, 2019) |
| "Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls." | 7.85 | Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer. ( Chang, WP; Lin, CC, 2017) |
| ""The effect of MElatonin and Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome" trial (MEDACIS) is a multicenter, double-blinded, placebo-controlled, randomized clinical trial." | 7.85 | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M, 2017) |
| "7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response." | 7.81 | Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study. ( Ayyash, HF; Cortese, S; Morton, R; Preece, P, 2015) |
| "To assess the influence of IFN-β treatment on melatonin secretion, fatigue and sleep characteristics in patients with MS." | 7.78 | Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. ( Golan, D; Lavi, I; Luboshitzky, R; Melamud, L; Miller, A, 2012) |
| "Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM)." | 7.77 | Relation of melatonin to sleep architecture in children with autism. ( Beyderman, L; Botzolakis, EJ; Leu, RM; Malow, BA; Surdyka, K; Wang, L, 2011) |
| "A recent study in the JAMA described the effects of long-term daily treatment with whole-day bright light in elderly patients with dementia, with or without the addition of melatonin (2." | 7.74 | [Symptomatic treatment in patients with dementia: light, but not melatonin, is probably worthwhile]. ( van Marum, RJ, 2008) |
| "The objective was to determine the circadian rhythm of melatonin in the Smith-Magenis syndrome (SMS), which causes behavioral problems and sleep disturbance." | 7.71 | Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome. ( Albrecht, U; Claustrat, B; De Blois, MC; De Leersnyder, H; Delobel, B; Lyonnet, S; Munnich, A; Romana, S; Vekemans, M; Viot, G; Von Kleist-Retzow, JC, 2001) |
| "The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects." | 7.71 | Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001) |
| "We studied the circadian rhythm of serum melatonin levels in two patients with classical Rett syndrome having severe sleep disorders; serum melatonin levels were measured before and during melatonin treatment using radioimmunoassay." | 7.70 | Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. ( Miyamoto, A; Oki, J; Okuno, A; Takahashi, S, 1999) |
| "The daily rhythm in serum melatonin levels was measured in patients with dementia of the degenerate type (Alzheimer's disease, Pick's disease and senile dementia of the Alzheimer type) by radioimmunoassay." | 7.69 | Daily rhythm of serum melatonin in patients with dementia of the degenerate type. ( Morita, Y; Ohara, K; Okamoto, N; Uchida, K, 1996) |
| "In patients with sleep disorders, significant improvement in sleep parameters, including subjective sleep quality, sleep latency, sleep duration, sleep efficiency, and daytime dysfunction, was observed, while in patients without sleep disorders, there was no significant improvement in sleep parameters." | 7.30 | The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study. ( Abbasian, S; Faghih Dinevari, M; Jabbaripour Sarmadian, A; Jafarzadeh, F; Nikniaz, Z; Riazi, A, 2023) |
| "Melatonin treatment is often recommended, yet supporting evidence is scarce." | 7.01 | Efficacy of Melatonin for Sleep Disturbance in Children with Persistent Post-Concussion Symptoms: Secondary Analysis of a Randomized Controlled Trial. ( Barlow, KM; Boyd, R; Brooks, B; Cameron, C; Dewey, D; Esser, MJ; Hill, M; Hutchison, J; Kirk, V; Kirton, A; MacMaster, F; Mikrogianakis, A; Nettel-Aguirre, A; Turley, B; Yeates, KO; Zemek, R, 2021) |
| "Chronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance." | 6.94 | Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP): a study protocol. ( Adam, R; Columb, M; Galley, H; Kanakarajan, S; Onyeakazi, U, 2020) |
| "Melatonin is a naturally occurring, safe and cheap hormone that can be administered to improve sleep." | 6.84 | Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial. ( Anstey, M; Choo, L; Ford, A; Hardie, M; Hensley, M; Hillman, D; Kelty, E; Martinez, FE; Murray, K; Palmer, R; Roberts, B; Singh, B; Wibrow, B, 2017) |
| "Melatonin has been advocated in treatment of sleep disorders, and its beneficial effect has been confirmed in insomnia." | 6.75 | Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010) |
| "Patients with Alzheimer dementia often display both agitated behavior and poor sleep." | 6.74 | Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. ( Ancoli-Israel, S; Connor, DJ; Corey-Bloom, J; Gehrman, PR; Martin, JL; Shochat, T, 2009) |
| "Melatonin treatment significantly improved subjective sleep quality, as compared with placebo (p = 0." | 6.71 | Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. ( Campos, FL; da Silva-Júnior, FP; de Bruin, PF; de Bruin, VM, 2004) |
| "Melatonin 5 mg was administered during two weeks in a double-blind setting and two weeks in an open setting successively or interrupted by two week of placebo." | 6.69 | Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. ( Kerkhof, GA; Nagtegaal, JE; Smits, MG; Swart, AC; Van Der Meer, YG, 1998) |
| "Treatment with melatonin effectively improved the clinical and neurophysiological aspects of rapid eye movement (REM) sleep behavior disorder (RBD), especially elderly individuals with underlying neurodegenerative disorders." | 6.53 | Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials. ( Chen, XY; Ding, T; Jia, QZ; Su, SW; Zhang, T; Zhang, W; Zhu, ZN, 2016) |
| "Melatonin has circadian, hypnotic, and free radical-scavenging effects, and preclinical data suggest benefits of melatonin on neurodegeneration." | 6.53 | Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases. ( Karroum, EG; Trotti, LM, 2016) |
| "Melatonin is a neurohormone secreted mainly by the pineal gland that controls circadian rhythm, which is primarily regulated by light." | 6.52 | Melatonin in aging women. ( Caglar, GS; Gursoy, AY; Kiseli, M, 2015) |
| "Melatonin is an effective chronobiotic agent changing the phase and amplitude of the sleep/wake rhythm and having cytoprotective and immunomodulatory properties useful to prevent a number of MS sequels." | 6.47 | Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin. ( Cardinali, DP; Pagano, ES; Reynoso, R; Scacchi Bernasconi, PA; Scacchi, P, 2011) |
| "Smith-Magenis syndrome (SMS) is a mental retardation syndrome with distinctive behavioral characteristics, dysmorphic features and congenital anomalies ascribed to an interstitial deletion of chromosome 17p11." | 6.43 | Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment. ( De Leersnyder, H, 2006) |
| "Serious childhood developmental disabilities are common, and are debilitating for the individual and their family." | 6.42 | Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary. ( Turk, J, 2003) |
| "Melatonin is a pineal hormone known to be important in the regulation of the circadian rhythm, including the sleep-wake cycle." | 6.42 | Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. ( Appleton, RE; Phillips, L, 2004) |
| "Previous study showed that both melatonin supplement and physical exercise intervention could improve sleep quality in children with autism spectrum disorders (ASD) with the increase in endogenous melatonin level." | 5.51 | Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders. ( Cheng, JCH; Ho, AWY; Lai, EWH; Lau, EYY; Lee, PH; Tse, ACY, 2022) |
| " We will include randomised clinical trials comparing melatonin versus placebo or no intervention for sleep disorders in children with neurodevelopmental disorders." | 5.51 | Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. ( Faltermeier, P; Gluud, C; Hermann, R; Horowitz, M; Jakobsen, JC; Juul, S; Jørgensen, CK; Moncrieff, J, 2022) |
| "Robust clinical evidence has not been available for melatonin, a drug commonly administered for treating sleep problems of children with autism spectrum disorder (ASD)." | 5.51 | Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial. ( Fukumizu, M; Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O, 2022) |
| "Children with neurodevelopmental disorders are at risk of sleep problems, typically difficulty getting to sleep, sleep/wake rhythm disturbances and reduced duration of sleep (insomnia)." | 5.42 | Melatonin for sleep problems in children with neurodevelopmental disorders. ( , 2015) |
| "This study aimed to evaluate the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD)." | 5.41 | Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. ( He, R; Li, F; Li, W; Liu, Z; Shen, H; Wei, L; Xie, X; Xiong, M, 2023) |
| "Patients with breast cancer undergoing lumpectomy had significantly disturbed sleep architecture the night after surgery, and these changes were normalised after 2 weeks." | 5.39 | Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy. ( Gögenur, I; Hansen, MV; Madsen, MT; Rosenberg, J; Wildschiødtz, G, 2013) |
| "Treatment with melatonin demonstrated efficacy, suggesting that, at least in a subgroup of patients, the endogenous melatonin level may not be sufficient to adequately set the sleep-wake cycles." | 5.37 | Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability. ( Botros, HG; Bourgeron, T; Briault, S; Chelly, J; de Brouwer, A; Delorme, R; Dumaine, A; Jamain, S; Kalscheuer, V; Lacombe, D; Laumonnier, F; Launay, JM; Leboyer, M; Moreno, S; Pagan, C; Poirier, K; Raynaud, M; Tzschach, A; van Bon, BW; Van Esch, H; Willemsen, MH, 2011) |
| "Melatonin has significant bearing on sleep architecture and a lack of melatonin may desynchronize endogenous rhythms allowing subsyndromal depression to manifest." | 5.36 | Altered sleep architecture and higher incidence of subsyndromal depression in low endogenous melatonin secretors. ( Kayumov, L; Marcu, S; Rahman, SA; Shapiro, CM, 2010) |
| "Clinical evidence is required about the long-term efficacy and safety of melatonin treatment for sleep problems in children with neurodevelopmental disorders (NDDs) who underwent adequate sleep hygiene interventions." | 5.34 | Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders. ( Hamada, I; Hayashi, M; Ishikawa, Y; Mishima, K; Nagamitsu, S; Sugioka, H; Takahashi, H; Yamashita, Y; Yotsuya, O; Yuge, K, 2020) |
| "Mental retardation is constant; there are major behavioral disturbances and severe sleep disorders." | 5.32 | [Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome]. ( Bresson, JL; Claustrat, B; de Blois, MC; De Leersnyder, H; Munnich, A; Sidi, D, 2003) |
| "Depression has become one of the most commonly prevalent neuropsychiatric disorders, and the main characteristics of depression are sleep disorders and melatonin secretion disorders caused by circadian rhythm disorders." | 5.22 | Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment. ( Jiang, YJ; Liu, J; Wang, YH; Wang, YQ; Zhao, HQ; Zou, MS, 2022) |
| ", light therapy, sleep deprivation, sleep phase advance and dark therapy, pharmacological in the form of melatonin and psychological consisting of interpersonal and social rhythm therapy or cognitive behavioral therapy for insomnia modified for patients with bipolar disorder." | 5.22 | [Chronotherapy of affective disorders: principles and clinical aspects]. ( Ludwig, VM; Münch, I; Ritter, P; Wirz-Justice, A, 2022) |
| "Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD)." | 5.16 | Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. ( Adkins, KW; Burnette, C; Fawkes, D; Goldman, SE; Malow, B; McGrew, SG; Wang, L, 2012) |
| " The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in patients with depressive state after cerebral infarction." | 5.16 | A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. ( Katayama, Y; Katsura, K; Nishiyama, Y; Otori, T; Sunami, E; Usuda, K, 2012) |
| "To determine the efficacy of melatonin on sleep problems in children with autistic spectrum disorder (ASD) and fragile X syndrome (FXS)." | 5.14 | The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. ( Anders, TF; Bacalman, S; Diaz, R; Goodlin-Jones, BL; Hagerman, RJ; Jacquemont, S; Wirojanan, J, 2009) |
| "To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time)." | 5.11 | Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin. ( English, J; Hancock, E; O'Callaghan, F; Osborne, JP, 2005) |
| "We report a randomized, double-blind, controlled, crossover trial investigating the response to oral melatonin using two dose regimens in patients with sleep disorders associated with tuberous sclerosis complex." | 5.11 | Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. ( Hancock, E; O'Callaghan, F; Osborne, JP, 2005) |
| "Melatonin was not only as effective as midazolam in alleviating preoperative anxiety in children, but it was also associated with a tendency towards faster recovery, lower incidence of excitement postoperatively and a lower incidence of sleep disturbance at week 2 postoperatively." | 5.11 | Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. ( Albassam, A; Aldammas, F; Alotibi, W; Naguib, M; Riad, W; Samarkandi, A; Thalaj, A, 2005) |
| "Compared with placebo, melatonin taken for two weeks significantly decreased mean abdominal pain score (2." | 5.11 | Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. ( Gwee, KA; Ho, KY; Leng, PH; Moochhala, SM; Song, GH, 2005) |
| "To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS)." | 5.11 | Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. ( Gwee, KA; Ho, KY; Lu, WZ; Moochhalla, S, 2005) |
| "Forty-four participants with DSM-IV diagnoses of dementia with sleep disturbance were selected for a seven week randomised double blind cross over trial of slow release melatonin 6 mg versus placebo." | 5.10 | Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. ( Blizard, R; Kennell-Webb, S; Raven, P; Serfaty, M; Warner, J, 2002) |
| "The results of a therapeutic trial of the use of melatonin in patients with tuberous sclerosis complex who also have severe sleep problems are reported." | 5.09 | Use of melatonin to treat sleep disorders in tuberous sclerosis. ( Clarke, AA; Hancock, E; Hunt, A; O'Callaghan, FJ; Osborne, JP, 1999) |
| "We studied the usefulness of melatonin for sleep disorders and emotional/behavior disturbances of patients with developmental disorders." | 5.09 | [Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. ( Ishizaki, A; Sugama, M; Takeuchi, N, 1999) |
| "The aim of the study was to determine the possible effect of melatonin treatment on disturbed sleep, fatigue and pain symptoms observed in fibromyalgia (FM) patients." | 5.09 | The effect of melatonin in patients with fibromyalgia: a pilot study. ( Arias, MA; Brusco, LI; Cardinalli, DP; Citera, G; Lázaro, MA; Maldonado-Cocco, JA; Rosemffet, MG; Scheines, EJ, 2000) |
| "This study explored the safety and efficacy of synthetic melatonin in the treatment of sleep problems in 20 children with developmental disabilities, in a randomized, double-blind, placebo-controlled 6-week trial of melatonin versus placebo." | 5.09 | Melatonin for treatment of sleep disorders in children with developmental disabilities. ( Dodge, NN; Wilson, GA, 2001) |
| "To assess 24-hour plasma melatonin profile as a marker of output rhythm from the circadian clock and to study sleep diaries as reflections of subjective sleep quality in patients with liver cirrhosis." | 5.08 | Disruption of the diurnal rhythm of plasma melatonin in cirrhosis. ( Bendok, B; Blei, AT; Finn, B; Rothke, S; Steindl, PE; Zee, PC, 1995) |
| "Five patients with rapid-cycling DSM-III-R bipolar disorder were treated with melatonin 10 mg q." | 5.08 | Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. ( Feldman-Naim, S; Leibenluft, E; Rosenthal, NE; Turner, EH; Wehr, TA, 1997) |
| "Evaluate melatonin as a treatment for subjective tinnitus." | 5.08 | Effect of melatonin on tinnitus. ( Olds, MJ; Rosenberg, SI; Rowan, PT; Silverstein, H, 1998) |
| "The occurrence of headache and its change after treatment with melatonin 5 mg were studied in 30 patients with delayed sleep phase syndrome." | 5.08 | Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. ( Kerkhof, GA; Nagtegaal, JE; Smits, MG; Swart, AC; van der Meer, YG, 1998) |
| "The authors' goal was to examine the hypnotic effects of slow-release melatonin during the initial 4 weeks of treatment with fluoxetine in 19 patients with major depressive disorder." | 5.08 | Melatonin for the treatment of sleep disturbances in major depressive disorder. ( Dolberg, OT; Grunhaus, L; Hirschmann, S, 1998) |
| "In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study." | 5.04 | Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976) |
| "Melatonin intervention has no significant influence on well-being, sleepiness, sleep quality, pain intensity after 1 and 3 hours, headache, depression, and dizziness for laparoscopic cholecystectomy." | 5.01 | The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials. ( Wang, Y; Xu, H; Yang, J; Zhang, J, 2019) |
| "To investigate the efficacy of exogenous administration of melatonin and melatonin receptor agonists for the improvement of delirium, sleep, and other clinical outcomes of subjects in the intensive care unit (ICU)." | 5.01 | Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. ( Gao, F; Li, Z; Sun, W; Zhang, Q; Zhang, S, 2019) |
| "The purpose of this manuscript is to review the evidence generated by clinical trials of pharmaceuticals in autism spectrum disorder (ASD), describe challenges in the conduct of such trials, and discuss future directions RECENT FINDINGS: Clinical trials in ASD have produced several compounds to adequately support the pharmacological treatment of associated symptom domains: attention deficit hyperactivity disorder (methylphenidate, atomoxetine, and alpha agonists), irritability/aggression (risperidone and aripiprazole), sleep (melatonin), and weight gain associated with atypical antipsychotic use (metformin)." | 4.98 | Clinical trials in autism spectrum disorder: evidence, challenges and future directions. ( Anagnostou, E, 2018) |
| "To determine the efficacy and safety of melatonin as therapy for sleep problems in children with neurodevelopmental disorders." | 4.98 | Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis. ( Abdelgadir, IS; Akobeng, AK; Gordon, MA, 2018) |
| " Endogenous secretion of melatonin decreases with aging across genders, and, among women, menopause is associated with a significant reduction of melatonin levels, affecting sleep." | 4.93 | Circadian rhythm and menopause. ( Pines, A, 2016) |
| "The current review aims to examine melatonin therapy for both sleep disturbances and cognitive function in dementia." | 4.91 | Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials. ( Chen, SD; Dammer, EB; Li, CB; Wang, G; Wang, LL; Xu, G; Xu, J, 2015) |
| "Melatonin is commonly recommended to treat sleep problems in children with developmental disabilities." | 4.91 | Melatonin Treatment in Children with Developmental Disabilities. ( Malow, BA; Schwichtenberg, AJ, 2015) |
| "Evidence from observational studies on light at night (LAN) exposure, sleep duration, endogenous melatonin levels, and risk for breast cancer in women is conflicting." | 4.90 | Light exposure at night, sleep duration, melatonin, and breast cancer: a dose-response analysis of observational studies. ( Deng, Q; Fan, WY; Wang, WY; Wang, X; Yang, WS, 2014) |
| "Melatonin is widely used for sleep disorders in patients with a range of developmental disorders and neurodisabilities, who also frequently have epilepsy." | 4.89 | Does melatonin affect epileptic seizures? ( Besag, FM; Jain, S, 2013) |
| "The screening of the literature was examined using the key words: burn patients, lymphocytopenia, skin oxidative stress, antioxidant, melatonin, and free radicals." | 4.84 | Melatonin as pharmacologic support in burn patients: a proposed solution to thermal injury-related lymphocytopenia and oxidative damage. ( Calvo, JR; Guerrero, JM; Lardone, PJ; Maldonado, MD; Murillo-Cabezas, F; Reiter, RJ; Tan, DX, 2007) |
| " Melatonin, the hormone of the pineal gland, received recently a great deal of attention because of its suggested role in aging processes and availability as over-the-counter drug or food supplement in some countries, including Poland." | 4.84 | Does melatonin play a role in aging processes? ( Karasek, M, 2007) |
| " This article focuses on the following specific neurologic diseases: nocturnal frontal lobe epilepsy and abnormal motor behaviors of epileptic origin, evaluating differential diagnosis with parasomnias; achondroplasia, confirming the crucial role of craniofacial deformity in determining sleep-disordered breathing; neuromuscular diseases, mainly Duchenne's muscular dystrophy and myotonic dystrophy; cerebral palsy, evaluating either the features of sleep architecture and the importance of the respiratory problems associated; headaches, confirming the strict relationships with sleep in terms of neurochemical and neurobehavioral substrates; and finally a review on the effectiveness of melatonin for sleep problems in children with neurologic syndromes and mental retardation, blindness, and epilepsy." | 4.81 | Sleep disorders in children with neurologic diseases. ( Bruni, O; Zucconi, M, 2001) |
| "Currently available as a dietary supplement, the pineal hormone melatonin is portrayed by the media as a formidable weapon against disease and aging." | 4.79 | Melatonin: media hype or therapeutic breakthrough? ( Kendler, BS, 1997) |
| " The current study aims to examine the incidence of vitamin D deficiency/insufficiency in the sample group and its effects on sleep quality and melatonin level." | 4.31 | Examination of correlations between vitamin D and melatonin levels with sleep among women aged 18-49 years. ( Demir, AD; İncedal Irgat, S; İncedal Sonkaya, Z; Kurtgöz, A; Yazgan, B, 2023) |
| "We developed methods for identifying people on the autism spectrum and defined their sleep problems using the key words, "sleep" or "melatonin", or International Classification of Diseases (ICD) codes." | 4.12 | Characterizing sleep disorders in an autism-specific collection of electronic health records. ( Davis, LK; Hucks, D; Johnston, R; Malow, BA; Maxwell-Horn, A; Niarchou, M; Singer, EV; Sutcliffe, JS, 2022) |
| "Poor sleep quality is a major problem in patients with autism spectrum disorder (ASD), and is attributed to low melatonin levels." | 4.12 | Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study. ( Abraham, SJ; Balamurugan, M; Dedeepiya, VD; Ikewaki, N; Iwasaki, M; Kandaswamy, RS; Kurosawa, G; Preethy, S; Raghavan, K; Sonoda, T, 2022) |
| "Melatonin promptly reversed ischemia-induced sleep disturbances." | 4.02 | Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats. ( Hao, SM; Huang, ZL; Qiu, MH; Qu, WM; Sun, FY; Zhong, ZG, 2021) |
| "Melatonin is accessed by almost one quarter of children on the autism spectrum in New Zealand, with higher observed rates among females and those aged between 5 and 11 years, of European ethnicity, and presenting with co-occurring mental health conditions." | 4.02 | Melatonin dispensing among New Zealand children aged 0-18 years with autism: a nationwide cross-sectional study. ( Bowden, N; Eggleston, MJF; McLay, LK; Schluter, PJ; Woodford, EC, 2021) |
| "Although children with persistent post-concussion symptoms reported more SRPs, this was not related to actigraphy sleep parameters or melatonin production." | 3.96 | Sleep Parameters and Overnight Urinary Melatonin Production in Children With Persistent Post-concussion Symptoms. ( Barlow, KM; Crowe, EG; Dewey, D; Esser, MJ; Girgulis, KA; Goldstein, G; Kirk, VG; Su, P; Vo, MK, 2020) |
| "To investigate potential delays in endogenous melatonin in individuals with obsessive-compulsive disorder (OCD)." | 3.96 | Sleep duration and timing in obsessive-compulsive disorder (OCD): evidence for circadian phase delay. ( Coles, ME; Deak, M; Schubert, J; Sharkey, KM; Stewart, E, 2020) |
| "Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with sleep disturbances that may result from abnormalities in melatonin production." | 3.91 | Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder. ( Babinska, K; Bartakovicova, K; Celusakova, H; Kemenyova, P; Siklenkova, L; Stebelova, K; Szapuova, Z; Vidosovicova, M; Waczulikova, I, 2019) |
| "This prospective cohort study captured the patterns of sleep, sleep-wake activity rhythm, and first-morning urinary melatonin in breast cancer patients undergoing adjuvant chemotherapy." | 3.91 | Disruption of sleep, sleep-wake activity rhythm, and nocturnal melatonin production in breast cancer patients undergoing adjuvant chemotherapy: prospective cohort study. ( Chan, DC; Ho, AW; Ho, CS; Kwok, CC; Li, W; Tse, LA; Wang, F; Wing, YK; Zhang, J, 2019) |
| "Objective To investigate the changes of serum melatonin(MLT)and glutathione(GSH)levels in patients with Parkinson's disease(PD)and explore their relationships with disease severity,cognitive dysfunction,and sleep disorders." | 3.91 | [Correlations of Melatonin and Glutathione Levels with Oxidative Stress Mechanism in Parkinson's Disease]. ( Bai, HY; DU, M; Wei, HJ, 2019) |
| "Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls." | 3.85 | Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer. ( Chang, WP; Lin, CC, 2017) |
| ""The effect of MElatonin and Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome" trial (MEDACIS) is a multicenter, double-blinded, placebo-controlled, randomized clinical trial." | 3.85 | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial. ( Andersen, LJ; Andersen, UO; Gögenur, I; Isbrand, A; Madsen, MT; Simonsen, E; Taskiran, M, 2017) |
| "7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response." | 3.81 | Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study. ( Ayyash, HF; Cortese, S; Morton, R; Preece, P, 2015) |
| " However, there have been few studies examining the possible association between melatonin levels and sleep quality in women with polycystic ovarian syndrome (PCOS)." | 3.79 | Poor sleep in PCOS; is melatonin the culprit? ( Brook, N; Cagampang, F; Cheong, Y; Hill, CM; Houldey, A; Macklon, N; Sadek, K; Shreeve, N; Tolhurst, M, 2013) |
| "To assess the influence of IFN-β treatment on melatonin secretion, fatigue and sleep characteristics in patients with MS." | 3.78 | Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. ( Golan, D; Lavi, I; Luboshitzky, R; Melamud, L; Miller, A, 2012) |
| " Here, we examined the evening onset of melatonin secretion, an important hormone for the initiation of sleep, in people with a complete cervical (tetraplegia) and thoracic (paraplegia) SCI, and age- and sex-matched able-bodied control participants." | 3.78 | Complete absence of evening melatonin increase in tetraplegics. ( Atkinson, G; Groothuis, JT; Hopman, MT; Jones, H; Nyakayiru, J; Thijssen, DH; Thompson, A; Verheggen, RJ, 2012) |
| "Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM)." | 3.77 | Relation of melatonin to sleep architecture in children with autism. ( Beyderman, L; Botzolakis, EJ; Leu, RM; Malow, BA; Surdyka, K; Wang, L, 2011) |
| " After weaning, dams were tested for anxiety, sleep recording or hormone profiling (ACTH, corticosterone and prolactin) and brain sampling (pineal melatonin and hippocampus serotonin)." | 3.76 | Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams. ( Andersen, ML; Bignotto, M; D'Almeida, V; Martins, PJ; Roizenblatt, S; Tufik, S, 2010) |
| "6 days post injury) and 23 age- and gender-matched healthy volunteers on polysomnographic sleep measures, salivary dim light melatonin onset (DLMO) time, and self-reported sleep quality, anxiety, and depression." | 3.76 | Sleep disturbance and melatonin levels following traumatic brain injury. ( Parcell, DL; Phipps-Nelson, J; Ponsford, JL; Rajaratnam, SM; Redman, JR; Shekleton, JA, 2010) |
| "A recent study in the JAMA described the effects of long-term daily treatment with whole-day bright light in elderly patients with dementia, with or without the addition of melatonin (2." | 3.74 | [Symptomatic treatment in patients with dementia: light, but not melatonin, is probably worthwhile]. ( van Marum, RJ, 2008) |
| "The features specific to the elderly nocturia group are as follows: (1) a decrease of the nighttime plasma melatonin level, (2) an increase of nighttime plasma catecholamine levels, (3) an increase of daytime and nighttime plasma natriuretic peptide levels, (4) an increase of blood pressure, (5) a decrease of daytime and nighttime urinary osmotic pressure, (6) an increase of total urine volume, and (7) an increase of the edema ratio before sleeping." | 3.74 | Biochemical and body composition analysis of nocturia in the elderly. ( Miyazato, M; Nishijima, S; Oda, M; Ogawa, Y; Owan, T; Sugaya, K, 2008) |
| "Melatonin, sleep disturbances, and symptoms (sleep, fatigue, mental) were compared among workers on permanent day, swing, and night shifts." | 3.73 | Melatonin, sleep, and shift work adaptation. ( Allen, E; Burch, JB; Johnson, W; Yost, MG, 2005) |
| "The objective was to determine the circadian rhythm of melatonin in the Smith-Magenis syndrome (SMS), which causes behavioral problems and sleep disturbance." | 3.71 | Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome. ( Albrecht, U; Claustrat, B; De Blois, MC; De Leersnyder, H; Delobel, B; Lyonnet, S; Munnich, A; Romana, S; Vekemans, M; Viot, G; Von Kleist-Retzow, JC, 2001) |
| "The aim of the study was to establish if there are differences in the 24-hour melatonin secretion profile between patients with major depression (before, and after treatment with clomipramine) compared to those in healthy subjects." | 3.71 | Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. ( Karasek, M; Rabe-Jablonska, J; Szymanska, A, 2001) |
| "We studied the circadian rhythm of serum melatonin levels in two patients with classical Rett syndrome having severe sleep disorders; serum melatonin levels were measured before and during melatonin treatment using radioimmunoassay." | 3.70 | Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. ( Miyamoto, A; Oki, J; Okuno, A; Takahashi, S, 1999) |
| "These results do not support the hypothesis that reduction of plasma melatonin concentration is a general characteristic of healthy aging." | 3.70 | Do plasma melatonin concentrations decline with age? ( Czeisler, CA; Daniels, JE; Dijk, DJ; Duffy, JF; Klerman, EB; Shanahan, TL; Zeitzer, JM, 1999) |
| "The daily rhythm in serum melatonin levels was measured in patients with dementia of the degenerate type (Alzheimer's disease, Pick's disease and senile dementia of the Alzheimer type) by radioimmunoassay." | 3.69 | Daily rhythm of serum melatonin in patients with dementia of the degenerate type. ( Morita, Y; Ohara, K; Okamoto, N; Uchida, K, 1996) |
| "The daily rhythms of melatonin, cortisol and body temperature were studied in 16 institutionalized subjects with the Lennox-Gastaut syndrome." | 3.68 | Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders. ( Alila, A; Hätönen, T; Heiskala, H; Laakso, ML; Leinonen, L, 1993) |
| "In patients with sleep disorders, significant improvement in sleep parameters, including subjective sleep quality, sleep latency, sleep duration, sleep efficiency, and daytime dysfunction, was observed, while in patients without sleep disorders, there was no significant improvement in sleep parameters." | 3.30 | The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study. ( Abbasian, S; Faghih Dinevari, M; Jabbaripour Sarmadian, A; Jafarzadeh, F; Nikniaz, Z; Riazi, A, 2023) |
| "Melatonin is a hormone that facilitates falling asleep and maintaining sleep and is also involved in the endogenous synchronization of internal biological clocks." | 3.11 | [Therapeutic approaches for sleep and rhythms disorders in children with ASD]. ( Broquère, MA; Claustrat, B; Delorme, R; Franco, P; Lecendreux, M; Schröder, CM; Tordjman, S, 2022) |
| "Melatonin intake was associated with a higher decrease in RBDSQ score compared to trazodone (P = 0." | 3.11 | Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson's disease and sleep disorders: a randomized, double-blind trial. ( Agah, E; Aghamollaii, V; Hadi, F; Mirsepassi, Z; Mousavi, SV; Tafakhori, A; Talachi, N; Tavanbakhsh, S, 2022) |
| "Melatonin was shown to be beneficial to sleep quality, sleep duration, and sleep efficiency." | 3.01 | The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review. ( Browne, G; Cassimatis, M; Orr, R, 2023) |
| "Melatonin was commonly associated with "naturalness" and "safety"." | 3.01 | Melatonin use in children and adolescents: A scoping review of caregiver perspectives. ( Cairns, R; Cheung, JMY; Grunstein, R; Lee, SKM; Smith, L; Tan, ECK, 2023) |
| "Melatonin treatment is often recommended, yet supporting evidence is scarce." | 3.01 | Efficacy of Melatonin for Sleep Disturbance in Children with Persistent Post-Concussion Symptoms: Secondary Analysis of a Randomized Controlled Trial. ( Barlow, KM; Boyd, R; Brooks, B; Cameron, C; Dewey, D; Esser, MJ; Hill, M; Hutchison, J; Kirk, V; Kirton, A; MacMaster, F; Mikrogianakis, A; Nettel-Aguirre, A; Turley, B; Yeates, KO; Zemek, R, 2021) |
| "Melatonin was most commonly received (70." | 3.01 | Evaluation of Medications Used for Hospitalized Patients With Sleep Disturbances: A Frequency Analysis and Literature Review. ( Patel, MVB; Snyder, HS; White, B, 2023) |
| "Chronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance." | 2.94 | Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP): a study protocol. ( Adam, R; Columb, M; Galley, H; Kanakarajan, S; Onyeakazi, U, 2020) |
| "Sleep disorders are a widespread condition in patients with Parkinson's disease (PD), which has been linked to a deregulation of the circadian cycle and therefore of the clock genes." | 2.94 | Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson's disease. ( Cárdenas-Bedoya, J; Cruz-Serrano, JA; de la Rosa, AC; Delgado-Lara, DL; González-Enríquez, GV; González-Usigli, H; Jiménez-Delgado, A; Macías-Islas, MA; Ortiz, GG; Pacheco-Moisés, F; Torres-Mendoza, BM, 2020) |
| "One hundred patients with sleep disorders and asthenic syndrome of various etiology and severity were studied." | 2.90 | [Clinical efficacy of neurometabolic therapy of dissomical disorders in asthenic syndrome]. ( Esipov, AV; Ivolgin, AF; Kalyagin, IE; Karakozov, AG; Katenko, SV; Kazakov, SP; Khritinin, DF; Levchenko, OB; Molodova, AI, 2019) |
| "Melatonin is a natural health product used for sleep disturbances." | 2.90 | Phase I dose-finding study for melatonin in pediatric oncology patients with relapsed solid tumors. ( Baruchel, S; Deyell, RJ; Johnston, DL; Morgenstern, D; Narendran, A; Nicksy, D; Samson, Y; Wu, B; Zupanec, S, 2019) |
| "Melatonin did not increase total sleep; however, blinded caregiver reports indicate treatment with melatonin provided considerable clinical benefit for some patients with Dravet syndrome and sleep disturbance." | 2.87 | Randomized Controlled Trial of Melatonin for Sleep Disturbance in Dravet Syndrome: The DREAMS Study. ( Ching, M; Davey, MJ; Ellis, C; Grinton, BE; Lightfoot, PA; Myers, KA; Roten, A; Scheffer, IE, 2018) |
| "Melatonin is a naturally occurring, safe and cheap hormone that can be administered to improve sleep." | 2.84 | Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial. ( Anstey, M; Choo, L; Ford, A; Hardie, M; Hensley, M; Hillman, D; Kelty, E; Martinez, FE; Murray, K; Palmer, R; Roberts, B; Singh, B; Wibrow, B, 2017) |
| "The main clinical manifestations are insomnia and excessive daytime sleepiness that often lead to clinically meaningful distress or cause mental, physical, social, occupational, educational, or other functional impairment." | 2.82 | Treatment of Circadian Rhythm Sleep-Wake Disorders. ( Chen, GH; Sun, SY, 2022) |
| "Melatonin is a hormonal product of the pineal gland, a fact that is often forgotten." | 2.82 | What do we really know about the safety and efficacy of melatonin for sleep disorders? ( Kennaway, DJ, 2022) |
| " Switching to morning dosing or to an alternative drug may help." | 2.82 | [Sleep disorders in patients with a neurocognitive disorder]. ( Carrier, J; Dang-Vu, TT; Moderie, C, 2022) |
| "Melatonin plays an important role in regulation and maintaining of the circadian rhythm." | 2.82 | Melatonin profile in healthy, elderly subjects - A systematic literature review. ( Godfrey, S; Iversen, HK; West, AS, 2022) |
| "Melatonin is a simple compound called N-acetyl-5-methoxy tryptamine and is known as a hormone controlling the circadian rhythm." | 2.82 | New Uses of Melatonin as a Drug; A Review. ( Pohanka, M, 2022) |
| " Using meta-ANOVA, studies on healthy participants showed advancing effects of melatonergic supplements and agonists on sleep-wake cycle according to dosing time and dosage, despite the fact that the original individual melatonin rhythm was within a normal range (fixed effect model standardized mean difference [95% Confidence Interval] = -0." | 2.82 | Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials. ( Beaulieu, S; Linnaranta, O; Moon, E; Partonen, T, 2022) |
| "The outcomes showed decreased daytime sleepiness, lessened sleep onset latency, diminished night-time awakenings, increased total sleep period and improved daytime attention in the melatonin-treated group; (4) Conclusions: Exogenously administered melatonin is effective in shift worker health personnel that are suffering from sleep disorders, and given its low adverse effects and tolerability, it might be recommended." | 2.82 | The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. ( Cantón-Manzano, C; Carriedo-Diez, B; Sanz-Valero, J; Tosoratto-Venturi, JL; Wanden-Berghe, C, 2022) |
| " Recent meta-analysis suggests that optimal dosage and dosing time might be important to maximize the efficacy of melatonin." | 2.82 | Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness. ( Kim, K; Linnaranta, O; Moon, E; Partonen, T, 2022) |
| "Melatonin has several unique features as it synchronises internal rhythm with daily and seasonal variations, regulates circadian rhythm and sleep-wake cycle." | 2.82 | Physiological and pharmacological perspectives of melatonin. ( Samanta, S, 2022) |
| "Melatonin also has sleep-inducing and anti-inflammatory properties and therefore might be useful for the management of AD." | 2.82 | Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial. ( Chang, YS; Chen, CA; Chiang, BL; Chu, KH; Dai, YS; Lee, JH; Lee, PL; Lin, MH; Lin, YT; Sun, C; Wan, KS; Wang, LC; Yang, YH; Yu, HH, 2016) |
| "Eight individuals with tetraplegia, having an absence of endogenous melatonin production and the presence of a sleep disorder." | 2.79 | Randomized controlled trial of pharmacological replacement of melatonin for sleep disruption in individuals with tetraplegia. ( Kiratli, BJ; Ku, B; Ota, D; Zeitzer, JM, 2014) |
| " The dosage of melaxen ranged from 3 to 6 mg depending on the respond to the minimal dose." | 2.78 | [An open-label non-comparative study of the efficacy and safety of melaxen in treatment of sleep disorders in alcohol dependent patients during the period of abstinence]. ( Andreeva, NE; Andrianov, FV; Anipchenko, AV; Eryshev, OF, 2013) |
| "Melatonin was associated with earlier waking times than placebo (29." | 2.77 | Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. ( Allport, T; Appleton, R; Choonara, I; Edmond, A; Gamble, C; Gringras, P; Jones, AP; Montgomery, P; Sutcliffe, A; Whitehouse, WP; Wiggs, L; Williamson, PR, 2012) |
| "We studied 38 patients with Parkinson's disease (PD) without dementia (mean age, 67." | 2.77 | [Sleep disorders in Parkinson's disease without dementia: a comparative randomized controlled study of melatonin and clonazepam]. ( Krasakov, IV; Litvinenko, IV; Tikhomirova, OV, 2012) |
| "IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed." | 2.76 | Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. ( Aksakal, FN; Cicek, N; Devran, A; Eryilmaz, OG; Mollamahmutoğlu, L; Sarikaya, E, 2011) |
| "Melatonin is a hypnotic and synchronizes circadian rhythms." | 2.75 | A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood. ( Blizard, R; Buszewicz, MJ; Osborne, D; Raven, PW; Serfaty, MA, 2010) |
| "Melatonin has been advocated in treatment of sleep disorders, and its beneficial effect has been confirmed in insomnia." | 2.75 | Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010) |
| "Patients with Alzheimer dementia often display both agitated behavior and poor sleep." | 2.74 | Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. ( Ancoli-Israel, S; Connor, DJ; Corey-Bloom, J; Gehrman, PR; Martin, JL; Shochat, T, 2009) |
| "Melatonin treatment for two months significantly improved sleep quality scores measured by the NHSMI test (1." | 2.74 | Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. ( Aramburu, O; Garzón, C; Guerrero, JM; Guzmán, T, 2009) |
| "Melatonin treatment significantly improved global PSQI scores (P = 0." | 2.73 | Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease. ( Bruin, PF; Bruin, VM; Machado, MO; Mota, RM; Nunes, DM; Pereira, ED, 2008) |
| "Melatonin has been shown to improve sleep in several conditions." | 2.73 | Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study. ( Carvalhedo de Bruin, PF; de Bruin, VM; de Lourdes Seabra, M; Lopes, LA; Magalhães, MC; Medeiros, CA, 2007) |
| "Methadone maintenance treatment clinic." | 2.73 | Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. ( Adelson, M; Bar-Hamburger, R; Hetzroni, T; Peles, E; Schreiber, S, 2007) |
| "Melatonin use was associated with a 1-hour increase in nocturnal sleep (SEI difference = 0." | 2.73 | Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial. ( Bourne, RS; Mills, GH; Minelli, C, 2008) |
| "Insomnia is a sleep disorder characterized by difficulty of falling asleep or maintaining sleep, which affects different age groups." | 2.72 | Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review. ( Alves, IA; Bandeira, VAC; Bueno, APR; Savi, FM, 2021) |
| "In the setting of Alzheimer's disease, insomnia is an even more complicated issue, with a higher overall prevalence than in the general population, greater complexity of contributing etiologies, and differences in diagnosis (at times based on caregiver observation of sleep disruption rather than subjective complaints by the individual with the disorder), and requiring more discretion in terms of treatment, particularly in regard to adverse effect profile concerns." | 2.72 | Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer's Disease. ( Bliwise, DL; Roland, JP, 2021) |
| "Introduction: insomnia represents a growing and important health problem." | 2.72 | [Nutrition impact on insomnia treatment]. ( Hernando-Requejo, O; Hernando-Requejo, V; Requejo Marcos, AM, 2021) |
| " This may be due to differences in the pharmacokinetic (PK) properties of melatonin formulations used in clinical trials." | 2.72 | Pharmacokinetics of exogenous melatonin in relation to formulation, and effects on sleep: A systematic review. ( Chapman, J; Comas, M; Garcia-Bennett, A; Gordon, CJ; Grunstein, RR; Moroni, I, 2021) |
| "Sleep disorders are common among Danish children and adolescents, particularly those with neurodevelopmental disabilities, as argued in this review." | 2.72 | [Sleep disorders in children and adolescents]. ( Agersted, ABA; Pagsberg, AK, 2021) |
| "Migraine and sleep disorders are common chronic diseases in the general population, with significant negative social and economic impacts." | 2.72 | Migraine and Sleep-An Unexplained Association? ( Budrewicz, S; Chojdak-Łukasiewicz, J; Nowakowska-Kotas, M; Waliszewska-Prosół, M, 2021) |
| "to determine the efficacy of melatonin to treat SD in AD." | 2.72 | Melatonin and Sleep Disturbances in Alzheimer's Disease. ( Cavestro, C; Islam, MA; Kamal, MA; Prodhan, AHMSU, 2021) |
| "Melatonin may also increase the efficacy of COVID-19 vaccination." | 2.72 | Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders. ( Cubała, WJ; Kania, A; Siemiński, M; Wichniak, A, 2021) |
| "Melatonin (3 mg/day) was used for 14 days." | 2.71 | Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder. ( Aronen, ET; Nieminen-von Wendt, T; Paavonen, EJ; Vanhala, R; von Wendt, L, 2003) |
| "Subjects with Alzheimer's disease and nighttime sleep disturbance were randomly assigned to 1 of 3 treatment groups: placebo, 2." | 2.71 | A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. ( Gamst, A; Grundman, M; Kaye, J; Schafer, K; Singer, C; Thal, LJ; Thomas, R; Tractenberg, RE, 2003) |
| "Melatonin treatment significantly improved subjective sleep quality, as compared with placebo (p = 0." | 2.71 | Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. ( Campos, FL; da Silva-Júnior, FP; de Bruin, PF; de Bruin, VM, 2004) |
| "Many patients with Parkinson's disease (PD) experience sleep-related symptoms." | 2.71 | Melatonin for sleep disturbances in Parkinson's disease. ( Aminoff, MJ; Carter, JH; Colling, E; Dowling, GA; Mastick, J; Singer, CM, 2005) |
| "Melatonin treatment did not influence significantly either the parameters of total blood count or glucose and serum lipids levels." | 2.70 | Effects of six months melatonin treatment on sleep quality and serum concentrations of estradiol, cortisol, dehydroepiandrosterone sulfate, and somatomedin C in elderly women. ( Karasek, M; Kolomecka, M; Pawlikowski, M; Wojtczak, A, 2002) |
| "Melatonin 5 mg was administered during two weeks in a double-blind setting and two weeks in an open setting successively or interrupted by two week of placebo." | 2.69 | Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. ( Kerkhof, GA; Nagtegaal, JE; Smits, MG; Swart, AC; Van Der Meer, YG, 1998) |
| "Melatonin was tested as a sleeping pill in five patients with neuronal ceroid lipofuscinoses." | 2.69 | Melatonin ineffective in neuronal ceroid lipofuscinosis patients with fragmented or normal motor activity rhythms recorded by wrist actigraphy. ( Hätönen, T; Heiskala, H; Kirveskari, E; Laakso, ML; Sainio, K; Santavuori, P, 1999) |
| " More extensive studies will be required to clarify the factors of dose-response and phase-response." | 2.69 | Light mask 500 lux treatment for delayed sleep phase syndrome. ( Ando, K; Cole, RJ; Elliott, JA; Kripke, DF, 1999) |
| "Oral melatonin therapy was used to treat-severe circadian sleep-wake disturbances in eight children and young adults in an open study." | 2.68 | Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances. ( Blennow, G; Palm, L; Wetterberg, L, 1997) |
| "Melatonin is a circadian hormone produced at night by the pineal gland, regulated by the light/dark cycle, under the control of the suprachiasmatic nucleus." | 2.66 | Influence of Dietary Sources of Melatonin on Sleep Quality: A Review. ( Hachul, H; Naufel, MF; Pereira, N; Ribeiro, EB; Tufik, S, 2020) |
| "Many types of sleep disorders have been reported in ASD individuals, but still lack a comprehensive study and in-depth analysis." | 2.66 | Understanding the role of sleep and its disturbances in Autism spectrum disorder. ( Brown, GM; Cardinali, DP; Karthikeyan, R; Pandi-Perumal, SR; Shakunthala, V; Spence, DW, 2020) |
| "People with autism spectrum disorder (ASD) commonly experience other comorbidities." | 2.66 | Sleep in autism: A biomolecular approach to aetiology and treatment. ( Baker, EK; Ballester, P; Peiró, AM; Richdale, AL, 2020) |
| "Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus." | 2.66 | Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine? ( Chu, MK; Kim, BS; Song, TJ, 2020) |
| " Each study's objectives, measures of outcomes, and dosing strategies of melatonin were reviewed along with the results and author's conclusions." | 2.66 | Review of Melatonin Supplementation for Sleep Disorders in Pediatric Special Populations. ( Abramova, R; Baron, J; Campbell, P; Parmar, S; Patel, K, 2020) |
| "Melatonin was generally regarded as safe and well tolerated." | 2.61 | Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review. ( Besag, FMC; Lao, KSJ; Vasey, MJ; Wong, ICK, 2019) |
| "Sleep disorders are a frequent problem with an important impact on the quality of life." | 2.61 | [Melatonin and sleep disorders: Overview of literature and testing in psychiatric practice]. ( De Hert, M; Desplenter, F; Huysmans, S, 2019) |
| "Melatonin is a physiological indoleamine involved in circadian rhythm regulation and it is currently used for secondary sleep disorders supported by empirical evidence." | 2.61 | Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis. ( Deng, C; Han, M; Jiang, S; Li, T; Lv, J; Reiter, RJ; Yang, Y; Yang, Z, 2019) |
| "While some sleep disorders are more challenging to treat, most can be easily managed with adequate interventions." | 2.61 | Sleep Disorders. ( K Pavlova, M; Latreille, V, 2019) |
| "Obstructive sleep apnea is the most prevalent type of obesity-related sleep disorder that lead to an increased risk for numerous chronic health conditions." | 2.61 | Obesity and sleep disturbance: the chicken or the egg? ( Annunziata, G; Barrea, L; Colao, A; Di Somma, C; Laudisio, D; Muscogiuri, G; Savastano, S, 2019) |
| " However, there is still uncertainty concerning dosing regimens and a lack of other data." | 2.61 | Pediatric sleep disturbances and treatment with melatonin. ( Argentiero, A; D'Alonzo, R; Di Genova, L; Esposito, S; Fattorusso, A; Laino, D; Mencarelli, A; Mencaroni, E, 2019) |
| "The consequences are variable, and sleep disorders can influence medical, psychological and developmental aspects of the growing child." | 2.58 | Sleep disorders during childhood: a practical review. ( Boudewyns, A; Glazemakers, I; Ophoff, D; Slaats, MA; Van Hoorenbeeck, K; Verhulst, SL, 2018) |
| "Atopic dermatitis is a chronic, pruritic inflammatory disease that often disrupts sleep in severely affected children, but there are limited studies to guide clinical management of these sleep problems." | 2.58 | Managing sleep disturbances in children with atopic dermatitis. ( Levoska, M; Patel, D; Shwayder, T, 2018) |
| "Treatment for insomnia with melatonin (MT) in children and adolescents aged 0-17 years has doubled since 2011." | 2.58 | [Melatonin for children with insomnia]. ( Berring-Uldum, A; Debes, NMM; Holst, H; Pedersen, CR, 2018) |
| "How can sleep deprivation trigger an epileptic seizure? How do circadian and hormonal changes influence sleep pattern and seizure occurrence? Can hormones or sleeping pills help with sleep in epilepsy? In this article we discuss these and many other questions on sleep in epilepsy, with an emphasis on sleep architecture, hormone changes, mechanistic factors, and possible prevention strategies." | 2.58 | Neuroendocrine aspects of improving sleep in epilepsy. ( Chuang, SH; Crepeau, AZ; Hunn, D; Maganti, R; Reddy, DS, 2018) |
| "Melatonin is a ubiquitous molecule in nature, being locally synthesized in several cells and tissues, besides being a hormone that is centrally produced in the pineal gland of vertebrates, particularly in mammals." | 2.58 | A brief review about melatonin, a pineal hormone. ( Amaral, FGD; Cipolla-Neto, J, 2018) |
| "Melatonin has been shown to synchronize the circadian rhythms, and improve the onset, duration and quality of sleep." | 2.55 | A review of sleep disorders and melatonin. ( Chen, F; Feng, Y; Geng, X; Li, C; Li, WA; Liu, W; Meng, X; Xie, Z; Yu, F, 2017) |
| "Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies." | 2.55 | Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. ( Auld, F; Maschauer, EL; Morrison, I; Riha, RL; Skene, DJ, 2017) |
| "Melatonin is a neurohormone that is involved in the modulation of a wide range of physiological processes, including maintenance of the circadian rhythm, mediation of photoperiodic information, regulation of the sleep-wake cycle, synchronization of cell physiology, antioxidant defense, and immune-modulation." | 2.55 | Melatonin, adolescence, and the brain: An insight into the period-specific influences of a multifunctional signaling molecule. ( Onaolapo, AY; Onaolapo, OJ, 2017) |
| "Treatment with melatonin effectively improved the clinical and neurophysiological aspects of rapid eye movement (REM) sleep behavior disorder (RBD), especially elderly individuals with underlying neurodegenerative disorders." | 2.53 | Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials. ( Chen, XY; Ding, T; Jia, QZ; Su, SW; Zhang, T; Zhang, W; Zhu, ZN, 2016) |
| "Melatonin has circadian, hypnotic, and free radical-scavenging effects, and preclinical data suggest benefits of melatonin on neurodegeneration." | 2.53 | Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases. ( Karroum, EG; Trotti, LM, 2016) |
| "Melatonin plays a major role in maintaining circadian rhythm." | 2.53 | Physiological melatonin levels in healthy older people: A systematic review. ( de Rooij, SE; Scholtens, RM; van Kempen, MF; van Munster, BC, 2016) |
| "Melatonin is a hormone produced by the pineal gland during the night in response to light/dark information received by the retina and its integration by the suprachiasmatic nucleus." | 2.52 | Potential safety issues in the use of the hormone melatonin in paediatrics. ( Kennaway, DJ, 2015) |
| "Melatonin is a neurohormone secreted mainly by the pineal gland that controls circadian rhythm, which is primarily regulated by light." | 2.52 | Melatonin in aging women. ( Caglar, GS; Gursoy, AY; Kiseli, M, 2015) |
| "Melatonin is an endogenous neurohormone produced predominantly in the pineal gland." | 2.50 | Melatonin in autism spectrum disorders. ( Frye, RE; Rossignol, DA, 2014) |
| "Circadian rhythm sleep disorders are caused by the disturbance of sleep-wake regulation in the central nervous system, disturbed input into the sensory organs, and decreased social activities." | 2.50 | [Sleep problems in dementia]. ( Oka, Y, 2014) |
| "Delirium is a serious neuropsychiatric syndrome of acute onset that occurs in approximately one in five general hospital patients and is associated with serious adverse outcomes that include loss of adaptive function, persistent cognitive problems and increased mortality." | 2.49 | Delirium: a disturbance of circadian integrity? ( Adamis, D; Dunne, C; Fitzgerald, JM; Meagher, DJ; O'Regan, N; Timmons, S; Trzepacz, PT, 2013) |
| "Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect." | 2.48 | Melatonin utility in neonates and children. ( Chen, YC; Huang, LT; Sheen, JM; Tain, YL, 2012) |
| "The literature describes sleep disorders as common in both conditions." | 2.48 | Interventions with a sleep outcome for children with cerebral palsy or a post-traumatic brain injury: a systematic review. ( Elder, DE; Galland, BC; Taylor, BJ, 2012) |
| "This article reviews common sleep disorders in children and pharmacologic options for them." | 2.48 | Pediatric sleep pharmacology. ( Pelayo, R; Yuen, K, 2012) |
| "Most is known about obstructive sleep apnea syndrome (OSAS)." | 2.47 | Sleep disturbances in people with epilepsy; prevalence, impact and treatment. ( de Weerd, AW; Gutter, T; van Golde, EG, 2011) |
| "Treatment of sleep disorders in visually impaired children is complicated by a complex pathophysiology, a high incidence of sleep disorders in this population, and a dearth of management options." | 2.47 | Therapeutic options in the management of sleep disorders in visually impaired children: a systematic review. ( Charles, B; Cooper, D; Dakin, C; Heussler, H; Khan, SA; McGuire, T; Norris, R; Pache, D, 2011) |
| "Melatonin is an effective chronobiotic agent changing the phase and amplitude of the sleep/wake rhythm and having cytoprotective and immunomodulatory properties useful to prevent a number of MS sequels." | 2.47 | Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin. ( Cardinali, DP; Pagano, ES; Reynoso, R; Scacchi Bernasconi, PA; Scacchi, P, 2011) |
| "Sleep and wake in Alzheimer's disease (AD) are often fragmented as manifested by bouts of wakefulness at night and napping during the day." | 2.46 | Non-pharmacologic management of sleep disturbance in Alzheimer's disease. ( David, R; Friedman, L; Noda, A; O'Hara, R; Robert, P; Yesavage, JA; Zeitzer, J, 2010) |
| "Circadian rhythm sleep disorders are common conditions manifested as misalignment between the sleep period and the physical/social 24-h environmental cycle." | 2.46 | Circadian rhythm sleep disorders. ( Lenz, Mdo C; Martinez, D, 2010) |
| "Bright light therapy is used to treat seasonal affective disorders." | 2.46 | Circadian rhythms and depression. ( Barriball, E; Boyce, P, 2010) |
| "Identifying and treating sleep disorders may result not only in improved sleep, but also impact favorably on daytime behavior and family functioning." | 2.46 | Sleep in children with autistic spectrum disorder. ( Cortesi, F; Giannotti, F; Ivanenko, A; Johnson, K, 2010) |
| "Higher incidences of sleep disorders such as restless legs syndrome, periodic limb movement disorder and sleep-disordered breathing have been reported in paediatric ADHD populations compared with control populations." | 2.46 | Sleep problems in the child with attention-deficit hyperactivity disorder: defining aetiology and appropriate treatments. ( Salpekar, J; Weiss, MD, 2010) |
| "There are specific sleep disorders (other than insomnia) for which pharmacotherapy plus behavioral strategies are warranted." | 2.46 | Pharmacotherapy in pediatric sleep disorders. ( Garbutt, A; Weiss, SK, 2010) |
| "Sleep disorders may affect between 20% and 30% of young children, and include problems getting to sleep (dyssomnias), or undesirable phenomena during sleep (parasomnias), such as sleep terrors and sleepwalking." | 2.46 | Sleep disorders in children. ( Bruni, O; Novelli, L, 2010) |
| "Sleep disorders may affect 20-30% of young children, and include excessive daytime sleepiness, problems getting to sleep (dysomnias), or undesirable phenomena during sleep (parasomnias), such as sleep terrors, and sleepwalking." | 2.44 | Sleep disorders in children. ( Dunne, D; Montgomery, P, 2007) |
| "Circadian rhythm disturbances, such as sleep disorders, are frequently seen in aging and are even more pronounced in Alzheimer's disease (AD)." | 2.44 | Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. ( Swaab, DF; Wu, YH, 2007) |
| "Pruritus is exacerbated at night in many systemic and dermatological diseases, resulting in reports of significantly diminished quality of life and sleep disturbances." | 2.44 | Nocturnal itch: why do we itch at night? ( Ishiuji, Y; Patel, T; Yosipovitch, G, 2007) |
| "Melatonin is a neurohormone that is secreted by the pineal gland and known to impact the sleep-wake cycle." | 2.44 | Melatonin. ( Piccirillo, JF, 2007) |
| "Melatonin has been successfully used to treat insomnia in children with attention-deficit hyperactivity disorder or autism, as well as in other neurodevelopmental disorders in which sleep disturbance is commonly reported." | 2.44 | Role of the melatonin system in the control of sleep: therapeutic implications. ( Cardinali, DP; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2007) |
| "Indeed, sleep disorders and low melatonin levels are frequently observed in ASD." | 2.44 | The possible interplay of synaptic and clock genes in autism spectrum disorders. ( Bourgeron, T, 2007) |
| "Circadian rhythm sleep disorders, such as jet lag syndrome and shift work sleep disorder, are those specifically attributed to dysfunctions or insufficiencies in the circadian system." | 2.43 | The human circadian system in normal and disordered sleep. ( Richardson, GS, 2005) |
| " There was no evidence of adverse effects of melatonin." | 2.43 | The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. ( Baker, G; Buscemi, N; Hartling, L; Hooton, N; Klassen, TP; Pandya, R; Tjosvold, L; Vandermeer, B; Vohra, S, 2005) |
| "Melatonin also has strong antioxidant properties (stronger than those of vitamin E), and an oncostatic action." | 2.43 | [Melatonin: what for?]. ( Touitou, Y, 2005) |
| " 17 randomised controlled trials with 651 participants showed no evidence of adverse effects of melatonin with short term use (three months or less)." | 2.43 | Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. ( Baker, G; Buscemi, N; Hartling, L; Hooton, N; Klassen, TP; Pandya, R; Tjosvold, L; Vandermeer, B; Vohra, S, 2006) |
| "Smith-Magenis syndrome (SMS) is a mental retardation syndrome with distinctive behavioral characteristics, dysmorphic features and congenital anomalies ascribed to an interstitial deletion of chromosome 17p11." | 2.43 | Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment. ( De Leersnyder, H, 2006) |
| "Melatonin plays an obvious role in the pathophysiology and treatment of sleep disorders and jetlag." | 2.43 | [Melatonin: physiological and pathophysiological aspects and possible applications]. ( Buijs, RM; de Graaff, MJ; Fliers, E; Hoekstra, JB; Holleman, F, 2006) |
| "In untreated schizophrenia, psychotic decompensation is associated with profound insomnia, one of the prodromal symptoms associated with psychotic relapse." | 2.43 | Sleep in schizophrenia: impairments, correlates, and treatment. ( Benson, KL, 2006) |
| "These include sleep disorders with a specific relationship to epilepsy, the influences of sleep and sleep deprivation on interictal epileptiform discharges, detrimental effects of seizures on sleep, and the effects (good and bad) of epilepsy treatments on sleep." | 2.42 | Sleep-related epilepsy. ( Bazil, CW, 2003) |
| "Serious childhood developmental disabilities are common, and are debilitating for the individual and their family." | 2.42 | Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary. ( Turk, J, 2003) |
| "Patients with dementias, such as Alzheimer's disease (AD), often have nocturnally disrupted sleep." | 2.42 | Sleep disorders in Alzheimer's disease and other dementias. ( Bliwise, DL, 2004) |
| "Melatonin is a pineal hormone known to be important in the regulation of the circadian rhythm, including the sleep-wake cycle." | 2.42 | Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. ( Appleton, RE; Phillips, L, 2004) |
| "Melatonin is a hormone mainly secreted by the pineal gland during the dark phase of the light-dark cycle." | 2.41 | [Melatonin. II. Physiological and therapeutic effects]. ( Bruls, E; Crasson, M; Legros, JJ; Van Reeth, O, 2000) |
| "Many neurological disorders are associated with abnormal 24-hour rhythms, including the sleep-wake cycle." | 2.41 | Current understanding of the circadian clock and the clinical implications for neurological disorders. ( Dugovic, C; Turek, FW; Zee, PC, 2001) |
| "Melatonin profiles are a diagnostic tool to distinguish between several forms of depression, like major depression, winter depression (SAD), unipolar depression, delayed sleep phase syndrome (DSPS)." | 2.41 | Melatonin deficiencies in women. ( Herold, J; Rohr, UD, 2002) |
| "Circadian Rhythm Sleep Disorders (CRSD) are a group of sleep disorders characterized by a de-synchronization between a person's biological clock and the environmental 24-hour schedule." | 2.41 | Circadian Rhythm Sleep Disorders (CRSD) in psychiatry--a review. ( Dagan, Y, 2002) |
| "Melatonin treatment improved sleep quality and suppressed sundowning." | 2.41 | The use of melatonin in Alzheimer's disease. ( Brusco, LI; Cardinali, DP; Furio, AM; Liberczuk, C, 2002) |
| "Some sleep disorders and circadian rhythm disturbances are the widely accepted indications for melatonin treatment." | 2.41 | Future of melatonin as a therapeutic agent. ( Cardinali, DP; Karasek, M; Pawlikowski, M; Reiter, RJ, 2002) |
| "Melatonin has clear acute and delayed effects on sleep and circadian rhythms." | 2.40 | Treatment of circadian rhythm disorders--melatonin. ( Arendt, J; Deacon, S, 1997) |
| " The optimal dosage and timing of drug administration is still unclear." | 2.40 | Melatonin: therapeutic use in sleep disorders. ( Chase, JE; Gidal, BE, 1997) |
| "Circadian rhythm sleep disorders which may result from dysfunction of biological clock have recently been noticed and the number of patients suffering from these types of sleep disorders have been increased." | 2.40 | [Advanced sleep phase syndrome (ASPS) and delayed sleep phase syndrome (DSPS)]. ( Kajimura, N; Takahashi, K, 1998) |
| " There is also an urgent need for safety data, both in animals and in humans, particularly when long-term use is envisaged." | 2.40 | Therapeutic applications of melatonin and related compounds. ( Defrance, R; Quera-Salva, MA, 1998) |
| "Melatonin has not been proven safe by the usual clinical trial criteria, but to date no catastrophes have been related to its use." | 2.40 | Use of melatonin for sleep and circadian rhythm disorders. ( Hughes, RJ; Lewy, AJ; Sack, RL, 1998) |
| "Melatonin has few immediate side-effects except drowsiness, but the effects of chronic administration are unclear." | 2.40 | Guidelines for prescribing melatonin. ( Avery, D; Landis, C; Lenz, M, 1998) |
| "Melatonin has received much ill-formed publicity, it being claimed that it is a panacea and an 'antiageing' treatment." | 2.40 | Disorders of the sleep-wake cycle in adults. ( Sedgwick, PM, 1998) |
| "Oral melatonin (MLT) has been used by our Vancouver research group in the treatment of paediatric sleep disorders since 1991; slightly over 200 children, mainly with multiple disabilities, who frequently had seizures, have been treated." | 2.40 | Melatonin treatment of non-epileptic myoclonus in children. ( Connolly, MB; Freeman, RD; Hamilton, D; Jan, JE; Laudon, M, 1999) |
| "Melatonin treatment has also been evaluated in the circadian sleep disorders: delayed sleep phase syndrome (DSPS) and non-24-hour sleep wake disorder." | 2.40 | Use of melatonin in the treatment of phase shift and sleep disorders. ( Arendt, J; Lockley, SW; Skene, DJ, 1999) |
| "(2) Only its use in jet lag, sleep disorders and advanced cancer has been tested clinically (albeit scantily)." | 2.40 | Melatonin: interesting, but not miraculous. ( , 1998) |
| "The rationale for the treatment of sleep disorders by scheduled exposure to bright light in seasonal affective disorder, jet lag, shift work, delayed sleep phase syndrome, and the elderly is, in part, based on a conceptual framework developed by nonclinical circadian rhythm researchers working with humans and other species." | 2.39 | Light treatment for sleep disorders: consensus report. II. Basic properties of circadian physiology and sleep regulation. ( Boulos, Z; Campbell, SS; Dijk, DJ; Eastman, CI; Lewy, AJ; Terman, M, 1995) |
| "Melatonin treatment increased plasma melatonin concentration and restored circadian rhythm." | 1.91 | Melatonin Treatment of Circadian Rhythm Sleep-Wake Disorder in Obese Children Affects the Brain-Derived Neurotrophic Factor Level. ( Hu, B; Huang, X; Huang, Y, 2023) |
| "Melatonin is a physiological indoleamine involved in circadian rhythm regulation and it is currently used for secondary sleep disorders caused by various diseases." | 1.91 | Melatonin effects on sleep quality of COVID-19 patients: a protocol for systematic review and meta-analysis of randomised controlled trials with trial sequential analysis. ( Guo, S; Sun, R; Zhang, H; Zhang, JJ, 2023) |
| "Parents of both groups reported that insomnia negatively affected their children behavior and caused stress, mood changes or physical fatigue in their daily life." | 1.91 | Sleep disturbances in subjects with autism spectrum disorder: A parental perspective. ( Bernardi, K; Bruni, G; Bruni, O; Ferri, R; Panerai, S; Prono, F, 2023) |
| "Melatonin was prescribed to 52 children, all but one were extended-release preparations." | 1.91 | Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort. ( Benny, A; Hewertson, V; Hill, CM; Joels, H; Joseph, B; Marshall, A; Piantino, C; Postigo, B; Sharpe, A, 2023) |
| "Prednisolone (PN) is a glucocorticoid (GC) analog that is clinically used to treat allergic inflammation and autoimmune diseases." | 1.72 | Prednisolone induces sleep disorders via inhibition of melatonin secretion by the circadian rhythm in zebrafish. ( Feng, N; Gen, N; Jiang, Y; Lu, X; Wang, P, 2022) |
| "Melatonin is a safe medication with multiple uses in sleep medicine for the treatment of circadian rhythm disorders, insomnia, and REM sleep behavior disorder." | 1.72 | [Pre-pandemic melatonin treatment for sleep disorders and COVID-19 infection. A retrospective cross-sectional study]. ( Cardinali, DP; Folgueira, A; González Cardozo, A; Rugiero, M; Valiensi, SM; Vera, VA, 2022) |
| "Melatonin pretreatment could restore circadian rhythm process by regulating circadian factor expression through post-translational modulation and prohibit the over-synthesis of melatonin in pineal gland." | 1.72 | Melatonin pretreatment prevents propofol-induced sleep disturbance by modulating circadian rhythm in rats. ( Dong, HJ; Li, JC; Li, S; Li, Y; Wang, HL; Xue, R; Yin, XL; Zhang, Y; Zhang, YZ, 2022) |
| "Melatonin PR treatment significantly reduced the ESS scores from T0 to T1, while the PSQI scores presented a trend of improvement from T0 to T1." | 1.72 | Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson's disease: a preliminary evidence. ( Cerroni, R; Fernandes, M; Liguori, C; Ludovisi, R; Mercuri, NB; Pierantozzi, M; Stefani, A, 2022) |
| "differed significantly." | 1.72 | Diurnal variation of clock genes expression and other sleep-wake rhythm biomarkers among acute ischemic stroke patients. ( Arstikyte, J; Bassetti, CL; Daiva, R; Kupcinskas, J; Pajediene, E; Paulekas, E; Petrikonis, K; Salteniene, V; Skieceviciene, J, 2022) |
| "Melatonin is a natural regulator of many physiological processes, and the decrease of its synthesis leads to various diseases, in particular, insomnia and metabolic disorders." | 1.62 | [The effect of long-term beta-blockers on melatonin secretion, sleep quality, and vascular brain damage]. ( Kozhevnikova, VV; Tikhomirova, OV; Zybina, NN, 2021) |
| "Most SMS patients have sleep disorders such as short total sleep time, frequent night waking, short sleep onset, and early morning waking." | 1.62 | [Sleep disturbance associated with Smith-Magenis syndrome]. ( Chen, L; Pan, M, 2021) |
| "Melatonin is a neuroendocrine regulator of the sleep-wake cycle." | 1.62 | Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice. ( Guo, X; Han, Y; Jia, X; Li, Z; Liu, C; Liu, Y; Shi, C; Shi, J; Song, Y; Sun, J; Sun, Z; Yang, N; Yuan, Y; Zhang, L; Zhang, W; Zhou, Y, 2021) |
| "Melatonin prescription was not associated with faster symptom recovery." | 1.62 | Sleep Problems and Melatonin Prescription After Concussion Among Youth Athletes. ( Howell, DR; Kirkwood, MW; Potter, MN; Provance, AJ; Wilson, JC; Wilson, PE, 2021) |
| "CRSWD are a distinct class of sleep disorders caused by alterations of the circadian time-keeping system, its entrainment mechanisms, or a misalignment of the endogenous circadian rhythm and the external environment." | 1.62 | Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities. ( Abbott, SM; Burgess, HJ; Crowley, SJ; Duffy, JF; Emens, JS; Epstein, LJ; Gamble, KL; Hasler, BP; Klerman, EB; Kristo, DA; Malkani, RG; Rahman, SA; Thomas, SJ; Wyatt, JK; Zee, PC, 2021) |
| "Having a history of optic neuritis is associated with improved sleep quality and executive functions but increased daytime sleepiness." | 1.56 | Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event. ( Akbayır, E; Arsoy, E; Benbir, G; Gencer, M; Karadeniz, D; Özyurt, S; Turan, S; Türkoğlu, R; Tüzün, E; Yılmaz, V, 2020) |
| "A melatonin rhythm was present in both groups, and no group differences were found on melatonin variables." | 1.56 | Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm. ( Bernard, F; Blais, H; Duclos, C; Dumont, M; Gosselin, N; Menon, DK; Paquet, J; Van der Maren, S, 2020) |
| "Depression is common in older people and is associated with underlying brain change increasing the risk of dementia." | 1.56 | Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study. ( Gordon, C; Hickie, IB; Hoyos, CM; Lewis, SJG; Naismith, SL; Norrie, L; Terpening, Z, 2020) |
| "In this study, we tested several sleep deprivation protocols (mechanical shakes and light interruptions) on Drosophila and delineated their influences on Drosophila sleep." | 1.56 | Screening of sleep assisting drug candidates with a Drosophila model. ( Ma, WW; Peng, IF; Wang, YY, 2020) |
| "Since both drugs are used to treat sleep disorders in Japan, we examined the ameliorative effects of YKS and YKSCH on circadian rhythm disturbance and compared their efficacy using a mouse model of circadian rhythm disruption." | 1.56 | Yokukansankachimpihange, a traditional Japanese (Kampo) medicine, enhances the adaptation to circadian rhythm disruption by increasing endogenous melatonin levels. ( Ikarashi, Y; Imamura, S; Mizoguchi, K; Oizumi, H; Omiya, Y; Tabuchi, M; Ueki, T, 2020) |
| "People with Parkinson's disease had significantly poorer sleep quality with higher subjective sleep scores (p < 0." | 1.56 | Melanopsin Cell Dysfunction is Involved in Sleep Disruption in Parkinson's Disease. ( Dumpala, S; Feigl, B; Kerr, GK; Zele, AJ, 2020) |
| "Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity." | 1.56 | Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism. ( Abel, EA; Mannin, OR; Marceau, K; Schwichtenberg, AJ, 2020) |
| "We aimed to study the prevalence of sleep disorders in early-treated PKU children and adolescents and assessed correlations with dopamine and serotonin status." | 1.51 | Prevalence of sleep disorders in early-treated phenylketonuric children and adolescents. Correlation with dopamine and serotonin status. ( Artuch, R; Campistol, J; Cuadras, D; Gassió, R; González, MJ; Ormazabal, A; Sans, O; Sierra, C, 2019) |
| "Melatonin is a hormone secreted by the pineal gland at night." | 1.51 | The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS). ( Geoffroy, PA; Lopez, R; Micoulaud Franchi, JA; Schroder, CM, 2019) |
| "Melatonin is an important regulator in human circadian rhythms and the sleep-wake cycle." | 1.48 | Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances. ( Brabant, G; Clusmann, H; Gebauer, J; Kreitschmann-Andermahr, I; Piroth, M; Rosenkranz, E; Siegel, S; Thissen, A, 2018) |
| "Evaluating sleep disorders following concussion is an important part of the assessment." | 1.46 | Sleep Disturbance Following Concussion Is a Risk Factor for a Prolonged Recovery. ( Bramley, H; Henson, A; Kong, L; Lewis, MM; Silvis, M; Stetter, C, 2017) |
| "These results suggest that the sleep disorders observed in the CRF group were probably related to the low production of melatonin observed in this population." | 1.43 | Analyses of melatonin, cytokines, and sleep in chronic renal failure. ( da Silva, NC; Pinato, L; Pinto, AR, 2016) |
| "Melatonin pretreatment were conducted before anesthesia for 7 Days." | 1.43 | Melatonin pretreatment prevents isoflurane-induced cognitive dysfunction by modulating sleep-wake rhythm in mice. ( Chu, S; Cui, Y; Gu, X; Ma, Z; Qian, Y; Song, J; Xia, T, 2016) |
| "Treatment with melatonin at 4 mM significantly attenuated the sleep problems and rescued the reduction in mEPSC and EPSP frequency in the hLRRK2 transgenic flies." | 1.43 | Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease. ( Chen, L; Gu, H; Guo, W; Huang, Y; Liang, F; Long, S; Lu, X; Nucifora, FC; Pei, Z; Ran, D; Ross, CA; Sun, X; Zeng, J; Zhao, X, 2016) |
| "The most common sleep problems were parasomnias (27." | 1.43 | Sleep and melatonin secretion abnormalities in children and adolescents with fetal alcohol spectrum disorders. ( Goril, S; Scott, L; Shapiro, CM; Zalai, D, 2016) |
| "Melatonin has anticarcinogenic properties in experimental models." | 1.42 | Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men. ( Aspelund, T; Batista, JL; Czeisler, CA; Fall, K; Flynn-Evans, E; Gudnason, V; Haneuse, S; Harris, T; Launer, L; Lockley, SW; Markt, SC; Mucci, LA; Rider, JR; Schernhammer, ES; Sigurdardottir, LG; Stampfer, MJ; Tamimi, RM; Valdimarsdottir, UA, 2015) |
| "Sleep problems in children with autism spectrum disorders (ASD) are under-recognized and under-treated." | 1.42 | Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects. ( Bellando, J; Brouwer, WB; Frye, RE; Kovacs, E; Kuhlthau, KA; Payakachat, N; Pyne, JM; Tilford, JM; Williams, DK, 2015) |
| "Children with neurodevelopmental disorders are at risk of sleep problems, typically difficulty getting to sleep, sleep/wake rhythm disturbances and reduced duration of sleep (insomnia)." | 1.42 | Melatonin for sleep problems in children with neurodevelopmental disorders. ( , 2015) |
| "Reduced insulin sensitivity was compensated by an increased insulin response to glucose, which may reflect an initial physiological adaptation to maintain normal blood sugar levels during sleep loss." | 1.42 | Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity. ( Depner, CM; Eckel, RH; Higgins, J; Markwald, RR; McHill, AW; Melanson, EL; Perreault, L; Smith, MR; Wright, KP, 2015) |
| "The parents of 18 children with migraine completed the Children's Sleep Habits Questionnaire and Pediatric Migraine Disability Assessment Score in Arabic." | 1.40 | Urinary 6-sulphatoxymelatonin levels and sleep disorders in children with migraine. ( Abou-Khadra, MK; Hassan, A; Kishk, NA; Shaker, OG, 2014) |
| "A mouse model of chronic neuropathic pain induced by partial sciatic nerve ligation (PSL) was employed." | 1.40 | Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. ( Chen, CR; Chen, L; Cheng, NN; Huang, ZL; Laudon, M; Liu, YY; Qu, WM; Urade, Y; Yin, D, 2014) |
| "Sleep disorders are common in patients with HIV/AIDS, and can lead to poor quality of life." | 1.40 | HIV Tat protein affects circadian rhythmicity by interfering with the circadian system. ( Cai, L; Cheng, S; Clauss, M; Green, LA; Hou, W; Jiang, Z; Li, Z; Wang, T; Wang, Y; Wang, Z; Wen, X, 2014) |
| "Melatonin suppression was significantly larger in children (88." | 1.40 | Influence of light at night on melatonin suppression in children. ( Harada, T; Higuchi, S; Lee, SI; Nagafuchi, Y, 2014) |
| "Patients with breast cancer undergoing lumpectomy had significantly disturbed sleep architecture the night after surgery, and these changes were normalised after 2 weeks." | 1.39 | Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy. ( Gögenur, I; Hansen, MV; Madsen, MT; Rosenberg, J; Wildschiødtz, G, 2013) |
| "Treatment with melatonin demonstrated efficacy, suggesting that, at least in a subgroup of patients, the endogenous melatonin level may not be sufficient to adequately set the sleep-wake cycles." | 1.37 | Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability. ( Botros, HG; Bourgeron, T; Briault, S; Chelly, J; de Brouwer, A; Delorme, R; Dumaine, A; Jamain, S; Kalscheuer, V; Lacombe, D; Laumonnier, F; Launay, JM; Leboyer, M; Moreno, S; Pagan, C; Poirier, K; Raynaud, M; Tzschach, A; van Bon, BW; Van Esch, H; Willemsen, MH, 2011) |
| "Melatonin in saliva was sampled at 5 time points (21:00, 23:00, 1:00, 7:00 and 9:00 h)." | 1.36 | Different melatonin rhythms and sleep-wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis. ( Hagen, EC; Kerkhof, GA; Koch, BC; Nagtegaal, JE; Wee, PM, 2010) |
| "Melatonin has significant bearing on sleep architecture and a lack of melatonin may desynchronize endogenous rhythms allowing subsyndromal depression to manifest." | 1.36 | Altered sleep architecture and higher incidence of subsyndromal depression in low endogenous melatonin secretors. ( Kayumov, L; Marcu, S; Rahman, SA; Shapiro, CM, 2010) |
| "Sleep in older adults with Alzheimer's disease can often be extremely fragmented, thus disturbing normal sleep-wake rhythms." | 1.36 | Sleep in older adults with Alzheimer's disease. ( Dowling, GA; Lee, KA; Song, Y; Strawbridge, WJ; Wallhagen, MI, 2010) |
| "Disturbed sleep and/or hypersomnia are direct consequences of shift work and therefore described as shift work disorder." | 1.36 | [Burden and health effects of shift work]. ( Heitmann, J, 2010) |
| "Sleep disorders are interrelated with medical and psychiatric illnesses." | 1.35 | Sleep disorders: causes, effects, and solutions. ( Tibbitts, GM, 2008) |
| "As melatonin has a major role in the regulation of sleep and other cyclical bodily activities and its synthesis is directly regulated by the SCN, we postulated that disturbed SCN function is likely to give rise to abnormal melatonin secretion in HD." | 1.35 | Delayed onset of the diurnal melatonin rise in patients with Huntington's disease. ( Aziz, NA; Frölich, M; Pijl, H; Roelfsema, F; Roos, RA; Schröder-van der Elst, JP; van der Bent, C, 2009) |
| " Performance testing and subjective evaluations occurred prior to dosing and following forced awakening at 15:00, 2 h after dosing." | 1.34 | Cognitive performance following premature awakening from zolpidem or melatonin induced daytime sleep. ( Cardenas, R; Eddy, DR; Fischer, J; Hickey, PA; Storm, WF; Welch, CB, 2007) |
| "Frequent and recurrent migraine headaches can, over time, pose the additional risks of stroke, brain damage, heart failure and attention deficit." | 1.33 | A chronopharmacological preventive treatment for sleep-related migraine headaches and chronic morning headaches: Nitric oxide supersensitivity can cause sleep-related headaches in a subset of patients. ( Eli, R; Fasciano, JA, 2006) |
| "Effective treatments now exist for many sleep disorders, such as OSA and RLS, and a major breakthrough in the treatment of narcolepsy seems imminent." | 1.32 | Sleep disorders. ( Fisch, BJ; Olejniczak, PW, 2003) |
| "Mental retardation is constant; there are major behavioral disturbances and severe sleep disorders." | 1.32 | [Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome]. ( Bresson, JL; Claustrat, B; de Blois, MC; De Leersnyder, H; Munnich, A; Sidi, D, 2003) |
| "Congenital blindness, acquired blindness, presence of bilateral prosthetic eyes or presence of normal human eyes did not produce different nocturnal sleep and 'free-running' pattern results." | 1.31 | Sleep/wake cycles in the dark: sleep recorded by polysomnography in 26 totally blind subjects compared to controls. ( Guilleminault, C; Leger, D; Paillard, M; Santos, C, 2002) |
| "Morvan's 'fibrillary chorea' or Morvan's syndrome is characterized by neuromyotonia (NMT), pain, hyperhydrosis, weight loss, severe insomnia and hallucinations." | 1.31 | Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. ( Avoni, P; Baruzzi, A; Carey, T; Clover, L; Cortelli, P; Gambetti, P; Liguori, R; Lugaresi, E; Montagna, P; Plazzi, G; Vincent, A, 2001) |
| "At the meningoencephalitis stage, human African trypanosomiasis (HAT), sleeping sickness, causes dysregulation of the circadian rhythm of the sleep/wake cycle, rather than hypersomnia." | 1.31 | [Sleeping sickness: major disorders of circadian rhythm]. ( Bisser, S; Bourdon, L; Buguet, A; Chapotot, F; Dumas, M; Radomski, MW, 2001) |
| "Melatonin treatments were successful in 6/11 patients." | 1.30 | Melatonin treatment for circadian rhythm sleep disorders. ( Hayakawa, T; Kamei, Y; Okawa, M; Ozaki, S; Shibui, K; Uchiyama, M; Urata, J, 1998) |
| "Melatonin treatment was better tolerated because of its ease of application." | 1.30 | Trials of bright light exposure and melatonin administration in a patient with non-24 hour sleep-wake syndrome. ( Hayakawa, T; Kamei, Y; Okawa, M; Ozaki, S; Shibui, K; Uchiyama, M; Urata, J, 1998) |
| "Monozygotic twins with Alzheimer's disease of 8 years duration were studied." | 1.30 | Monozygotic twins with Alzheimer's disease treated with melatonin: Case report. ( Brusco, LI; Cardinali, DP; Márquez, M, 1998) |
| "Melatonin treatment was successful in two patients (one with and one without chronotherapy)." | 1.30 | Circadian rhythm sleep disorders in adolescents: clinical trials of combined treatments based on chronobiology. ( Ichikawa, H; Okawa, M; Ozaki, S; Shibui, K; Uchiyama, M, 1998) |
| "Sleep disorders are common in NCL patients." | 1.29 | Circadian rhythm studies in neuronal ceroid-lipofuscinosis (NCL). ( Alila, A; Hàtònen, TH; Heikkilä, E; Heiskala, H; Laakso, ML; Salmi, T; Santavuori, P; Telakivi, T, 1995) |
| "Colic is periodic behavior occurring at the end of the day during the first 3 months of life characterized by crying." | 1.28 | Colic, sleep inertia, melatonin and circannual rhythms. ( Weissbluth, L; Weissbluth, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (1.50) | 18.7374 |
| 1990's | 149 (20.33) | 18.2507 |
| 2000's | 168 (22.92) | 29.6817 |
| 2010's | 259 (35.33) | 24.3611 |
| 2020's | 146 (19.92) | 2.80 |
| Authors | Studies |
|---|---|
| Tikhomirova, OV | 2 |
| Zybina, NN | 1 |
| Kozhevnikova, VV | 1 |
| Tsukinaga, A | 1 |
| Mihara, T | 1 |
| Takeshima, T | 1 |
| Tomita, M | 1 |
| Goto, T | 1 |
| Yamanaka, T | 1 |
| Sun, SY | 1 |
| Chen, GH | 1 |
| Hao, SM | 1 |
| Zhong, ZG | 1 |
| Qu, WM | 2 |
| Huang, ZL | 2 |
| Sun, FY | 1 |
| Qiu, MH | 1 |
| Bueno, APR | 1 |
| Savi, FM | 1 |
| Alves, IA | 1 |
| Bandeira, VAC | 1 |
| Roland, JP | 1 |
| Bliwise, DL | 2 |
| Kennaway, DJ | 6 |
| Le, B | 1 |
| White, ACG | 1 |
| Chaudhari, A | 1 |
| Al-Mutawaly, N | 1 |
| White, JE | 1 |
| Lee, WK | 1 |
| Hsu, YL | 1 |
| White, JD | 1 |
| Pan, M | 1 |
| Chen, L | 3 |
| Moderie, C | 1 |
| Carrier, J | 1 |
| Dang-Vu, TT | 1 |
| Wang, YQ | 1 |
| Jiang, YJ | 1 |
| Zou, MS | 1 |
| Liu, J | 2 |
| Zhao, HQ | 1 |
| Wang, YH | 1 |
| Godfrey, S | 1 |
| Iversen, HK | 1 |
| West, AS | 1 |
| Pohanka, M | 1 |
| Lim, S | 1 |
| Park, S | 3 |
| Koyanagi, A | 1 |
| Yang, JW | 1 |
| Jacob, L | 1 |
| Yon, DK | 1 |
| Lee, SW | 1 |
| Kim, MS | 1 |
| Il Shin, J | 1 |
| Smith, L | 2 |
| Jiang, Y | 1 |
| Gen, N | 1 |
| Wang, P | 1 |
| Feng, N | 1 |
| Lu, X | 2 |
| Tse, AC | 1 |
| Lee, PH | 3 |
| Zhang, J | 4 |
| Chan, RC | 1 |
| Ho, AW | 2 |
| Lai, EW | 1 |
| Golding, H | 1 |
| Ritonja, JA | 1 |
| Day, AG | 1 |
| Aronson, KJ | 2 |
| Tranmer, J | 2 |
| Moon, E | 2 |
| Partonen, T | 3 |
| Beaulieu, S | 1 |
| Linnaranta, O | 2 |
| Schröder, CM | 2 |
| Broquère, MA | 1 |
| Claustrat, B | 5 |
| Delorme, R | 3 |
| Franco, P | 2 |
| Lecendreux, M | 1 |
| Tordjman, S | 1 |
| McGowan, NM | 1 |
| Kim, DS | 1 |
| de Andres Crespo, M | 1 |
| Bisdounis, L | 1 |
| Kyle, SD | 1 |
| Saunders, KEA | 1 |
| Li, H | 1 |
| Liu, M | 1 |
| Zhang, C | 1 |
| Singer, EV | 2 |
| Niarchou, M | 2 |
| Maxwell-Horn, A | 1 |
| Hucks, D | 1 |
| Johnston, R | 1 |
| Sutcliffe, JS | 1 |
| Davis, LK | 2 |
| Malow, BA | 6 |
| Leelaviwat, N | 1 |
| Mekraksakit, P | 1 |
| Cross, KM | 1 |
| Landis, DM | 1 |
| McLain, M | 1 |
| Sehgal, L | 1 |
| Payne, JD | 1 |
| Valiensi, SM | 1 |
| Folgueira, A | 1 |
| Vera, VA | 1 |
| González Cardozo, A | 1 |
| Cardinali, DP | 15 |
| Rugiero, M | 1 |
| Yin, XL | 1 |
| Li, JC | 1 |
| Xue, R | 1 |
| Li, S | 1 |
| Zhang, Y | 1 |
| Dong, HJ | 1 |
| Li, Y | 2 |
| Wang, HL | 1 |
| Zhang, YZ | 1 |
| Liguori, C | 1 |
| Fernandes, M | 1 |
| Cerroni, R | 1 |
| Ludovisi, R | 1 |
| Mercuri, NB | 1 |
| Stefani, A | 1 |
| Pierantozzi, M | 1 |
| Tedroff, K | 1 |
| von Euler, M | 1 |
| Dahlén, E | 1 |
| Kim, JH | 1 |
| Elkhadem, AR | 1 |
| Duffy, JF | 5 |
| Hadi, F | 1 |
| Agah, E | 1 |
| Tavanbakhsh, S | 1 |
| Mirsepassi, Z | 1 |
| Mousavi, SV | 1 |
| Talachi, N | 1 |
| Tafakhori, A | 1 |
| Aghamollaii, V | 1 |
| Ludwig, VM | 1 |
| Münch, I | 1 |
| Wirz-Justice, A | 4 |
| Ritter, P | 1 |
| Salanitro, M | 1 |
| Wrigley, T | 1 |
| Ghabra, H | 1 |
| de Haan, E | 1 |
| Hill, CM | 3 |
| Solmi, M | 1 |
| Cortese, S | 3 |
| Tse, ACY | 2 |
| Lau, EYY | 1 |
| Cheng, JCH | 1 |
| Ho, AWY | 1 |
| Lai, EWH | 2 |
| Bartakovicova, K | 2 |
| Kemenyova, P | 2 |
| Belica, I | 1 |
| Janik Szapuova, Z | 1 |
| Stebelova, K | 2 |
| Waczulikova, I | 2 |
| Ostatnikova, D | 1 |
| Babinska, K | 2 |
| Straub, P | 1 |
| Diaz, S | 1 |
| Grigg-Damberger, M | 1 |
| Pajediene, E | 1 |
| Paulekas, E | 1 |
| Salteniene, V | 1 |
| Skieceviciene, J | 1 |
| Arstikyte, J | 1 |
| Petrikonis, K | 1 |
| Kupcinskas, J | 1 |
| Bassetti, CL | 1 |
| Daiva, R | 1 |
| Shimura, A | 1 |
| Kanno, T | 1 |
| Inoue, T | 1 |
| Reiter, AM | 1 |
| Roach, GD | 1 |
| Sargent, C | 1 |
| Raghavan, K | 1 |
| Dedeepiya, VD | 1 |
| Kandaswamy, RS | 1 |
| Balamurugan, M | 1 |
| Ikewaki, N | 1 |
| Sonoda, T | 1 |
| Kurosawa, G | 1 |
| Iwasaki, M | 1 |
| Preethy, S | 1 |
| Abraham, SJ | 1 |
| Carriedo-Diez, B | 1 |
| Tosoratto-Venturi, JL | 1 |
| Cantón-Manzano, C | 1 |
| Wanden-Berghe, C | 1 |
| Sanz-Valero, J | 1 |
| Dack, R | 1 |
| Garstang, JJ | 1 |
| Poza, JJ | 1 |
| Pujol, M | 1 |
| Ortega-Albás, JJ | 1 |
| Romero, O | 1 |
| Hou, H | 1 |
| Wu, S | 1 |
| Qiu, Y | 1 |
| Song, F | 1 |
| Deng, L | 1 |
| Meyer, N | 1 |
| Harvey, AG | 1 |
| Lockley, SW | 8 |
| Dijk, DJ | 10 |
| Kim, K | 3 |
| Cassimatis, M | 1 |
| Browne, G | 1 |
| Orr, R | 1 |
| Pérez-Medina-Carballo, R | 3 |
| Kosmadopoulos, A | 3 |
| Boudreau, P | 3 |
| Robert, M | 3 |
| Walker, CD | 3 |
| Boivin, DB | 4 |
| Jørgensen, CK | 3 |
| Hermann, R | 3 |
| Juul, S | 3 |
| Faltermeier, P | 3 |
| Horowitz, M | 3 |
| Moncrieff, J | 3 |
| Gluud, C | 3 |
| Jakobsen, JC | 3 |
| Jalilolghadr, S | 1 |
| Roozmehr, S | 1 |
| Yazdi, Z | 1 |
| Soltanabadi, M | 1 |
| Nordholm, D | 1 |
| Jensen, MA | 1 |
| Glenthøj, LB | 1 |
| Kristensen, TD | 1 |
| Wenneberg, C | 1 |
| Garde, AH | 1 |
| Nordentoft, M | 1 |
| Nogueira, HA | 1 |
| de Castro, CT | 1 |
| da Silva, DCG | 1 |
| Pereira, M | 1 |
| Larsson, I | 1 |
| Aili, K | 1 |
| Lönn, M | 1 |
| Svedberg, P | 1 |
| Nygren, JM | 1 |
| Ivarsson, A | 1 |
| Johansson, P | 1 |
| Tabriz, AG | 1 |
| Mithu, MS | 1 |
| Antonijevic, MD | 1 |
| Vilain, L | 1 |
| Derrar, Y | 1 |
| Grau, C | 1 |
| Morales, A | 1 |
| Katsamenis, OL | 1 |
| Douroumis, D | 1 |
| Campos, LA | 2 |
| Baltatu, OC | 2 |
| Senar, S | 1 |
| Ghimouz, R | 1 |
| Alefishat, E | 1 |
| Cipolla-Neto, J | 3 |
| Huang, X | 1 |
| Huang, Y | 2 |
| Hu, B | 1 |
| Tuft, C | 1 |
| Matar, E | 1 |
| Menczel Schrire, Z | 1 |
| Grunstein, RR | 5 |
| Yee, BJ | 1 |
| Hoyos, CM | 2 |
| Bazin, B | 1 |
| Geoffroy, PA | 2 |
| Benzaquen, H | 1 |
| Maruani, J | 1 |
| Romier, A | 1 |
| Lejoyeux, M | 1 |
| D'ortho, MP | 2 |
| Frija-Masson, J | 1 |
| Xiong, M | 1 |
| Li, F | 1 |
| Liu, Z | 1 |
| Xie, X | 1 |
| Shen, H | 1 |
| Li, W | 2 |
| Wei, L | 1 |
| He, R | 1 |
| Pundir, M | 1 |
| De Rosa, MC | 1 |
| Lobanova, L | 1 |
| Abdulmawjood, S | 1 |
| Chen, X | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Procedure Started in the Morning and Afternoon on Early Postoperative Sleep Function and Postoperative Recovery in Patients Under General Anesthesia[NCT04103528] | 62 participants (Actual) | Interventional | 2018-10-09 | Completed | |||
| Melatonin Replacement Therapy Effects on Cardiac Autonomic Activity in Pinealectomized Patients[NCT03885258] | Early Phase 1 | 5 participants (Actual) | Interventional | 2017-05-02 | Completed | ||
| Phase II/III Clinical Trial of NPC-15 - Verification of the Efficacy for Sleep Disorders of Children With Autism Spectrum Disorders -[NCT02757066] | Phase 2/Phase 3 | 196 participants (Actual) | Interventional | 2016-06-16 | Completed | ||
| Mirtazapine for the Treatment of Sleep Disorders in Alzheimer's Disease: a Randomized, Double-blind, Placebo-controlled Study[NCT01867775] | Phase 3 | 30 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | ||
| A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia[NCT03066518] | Phase 4 | 40 participants (Actual) | Interventional | 2016-01-15 | Completed | ||
| Phase IV Study Safety & Feasibility of Sodium Oxybate in Mild Alzheimer's Disease Patients.[NCT00706186] | Phase 4 | 4 participants (Actual) | Interventional | Terminated (stopped due to Withdrawn by Investigator, protocol in revision) | |||
| [NCT00000171] | Phase 3 | 0 participants | Interventional | Completed | |||
| A Double-blind, Randomized Pilot Study to Evaluate the Effects of Galantamine and Donepezil on Sleep and Attention and Gastrointestinal (GI) Tolerance in Patients With Mild to Moderate Alzheimer's Disease (AD)[NCT00035204] | Phase 4 | 63 participants (Actual) | Interventional | Completed | |||
| A Double-blind, Parallel Group, Randomized, Placebo Controlled Study of the Efficacy of Circadin® 2mg in Patients With Mild to Moderate Alzheimer Disease (AD) Treated With Acetylcholinesterase (AChE) Inhibitor[NCT00940589] | Phase 2 | 73 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of 8 Week Treatment of Rozerem 8 mg (QHS) in Sleep Disturbed, Mild to Moderately Severe Alzheimer's Disease Subjects[NCT00325728] | Phase 2 | 74 participants (Actual) | Interventional | 2006-03-21 | Completed | ||
| The Effect of Anticholinesterase Drugs on Sleep in Alzheimer's Disease Patients[NCT00480870] | Phase 4 | 65 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| Modafinil Treatment for Sleep/Wake Disturbances in Older Adults[NCT00626210] | Phase 4 | 2 participants (Actual) | Interventional | 2008-02-29 | Terminated | ||
| Does Zolpidem CR Treatment Change Clinical Outcomes in Elderly Hospitalized Patients With Dementia- A Pilot Study[NCT00814502] | 20 participants (Actual) | Interventional | 2008-12-31 | Completed | |||
| Efficacy of Pain Treatment on Depression in Patients With Dementia. A Randomized Clinical Trial.[NCT02267057] | Phase 4 | 163 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Trazodone for the Treatment of Sleep Disorders in Alzheimer's Disease: a Randomised, Double-blind, Placebo-controlled Study[NCT01142258] | Phase 3 | 40 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| A Phase III Randomized, Placebo-Controlled Clinical Trial to Study the Safety and Efficacy of Suvorexant (MK-4305) for the Treatment of Insomnia in Subjects With Alzheimer's Disease[NCT02750306] | Phase 3 | 285 participants (Actual) | Interventional | 2016-05-23 | Completed | ||
| A Multinational, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of the Effect on Cognitive Performance, Safety, and Tolerability of SAR110894D at the Doses of 0.5 mg, 2 mg, and 5 mg/Day for 24 Weeks in Patients With Mild t[NCT01266525] | Phase 2 | 291 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| A Phase IIa Safety and Tolerability Study to Investigate the Effect on Sleep of 3 Doses of AZD5213 and Placebo in Patients With Mild Alzheimer's Disease and Mild Cognitive Impairment During 4 Weeks of Treatment, Placebo-Controlled[NCT01548287] | Phase 2 | 164 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Study of the Efficacy of Melatonin in the Burning Mouth Syndrome[NCT03788733] | 80 participants (Anticipated) | Interventional | 2018-12-14 | Recruiting | |||
| Efficacy of Cranial Manual Therapy in the Treatment of Chronic Insomnia Disorder[NCT05257317] | 50 participants (Anticipated) | Interventional | 2022-02-28 | Recruiting | |||
| A Randomised Double-blind Placebo-controlled Trial on Encapsulated Lemon Balm Efficacy and Tolerance on Sleep Quality Changes, and Mood and Wellbeing Effects Using Objective and Subjective Measures[NCT05422599] | 99 participants (Actual) | Interventional | 2022-05-05 | Completed | |||
| Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit[NCT03659760] | 40 participants (Anticipated) | Interventional | 2018-09-03 | Recruiting | |||
| Examining the Association Between Physical Activity and Sleep Quality in Children With Autism Spectrum Disorder Using Melatonin-mediated Mechanism Model: A Randomized Controlled Trial[NCT03348982] | 32 participants (Anticipated) | Interventional | 2018-01-31 | Not yet recruiting | |||
| Study of the Influence of an Osteopathic Treatment Protocol on the Improvement of Sleep: a Double-blind Randomized Controlled Trial[NCT05899972] | 50 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950] | 104 participants (Anticipated) | Interventional | 2017-06-26 | Recruiting | |||
| Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS)[NCT00246454] | 156 participants (Anticipated) | Observational | 2003-09-30 | Recruiting | |||
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| Circadian Disturbances in People With Mental Disease[NCT05413486] | 86 participants (Anticipated) | Observational | 2022-04-04 | Recruiting | |||
| Melatonin Replacement for Treatment of Sleep Disruption[NCT00507546] | Phase 4 | 12 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos[NCT05030948] | 236 participants (Actual) | Interventional | 2021-08-27 | Active, not recruiting | |||
| Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury[NCT02732288] | 1 participants (Actual) | Interventional | 2016-05-31 | Terminated (stopped due to Interrupted by Covid-19) | |||
| Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment[NCT00834886] | Phase 4 | 40 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832] | 30 participants (Anticipated) | Interventional | 2016-09-21 | Completed | |||
| Effect of School Based Ambient Bright White Light Intervention on Adolescents´ Sleep Quality, Depression and Mood[NCT05555186] | 300 participants (Anticipated) | Interventional | 2022-09-05 | Recruiting | |||
| Trazodone vs. Quetiapine for the Treatment of ICU Delirium: A Prospective Observational Pilot Study[NCT05307003] | 60 participants (Anticipated) | Observational | 2023-04-01 | Recruiting | |||
| Comparison of Trazodone vs Quetiapine vs Placebo for the Treatment of ICU Delirium: A Randomized Controlled Trial (The TraQ Study)[NCT05085808] | Phase 4 | 30 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | ||
| Association Between Melatonin Use and Improved Sleep Quality After Total Knee Arthroplasty: A Randomized Control Trial[NCT05332717] | 176 participants (Actual) | Interventional | 2022-01-10 | Completed | |||
| Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease[NCT04287543] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2021-05-31 | Withdrawn (stopped due to Due to the COVID-19 pandemic, we were unable to begin the study) | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| A Single Center, Open Label Prospective Observational Pilot Study to Evaluate the Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)[NCT05922995] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | ||
| Melatonin for Adolescent Migraine Prevention Study (The MAP Study).[NCT03150797] | Phase 2 | 72 participants (Actual) | Interventional | 2017-08-02 | Terminated (stopped due to Insufficient Fund) | ||
| Effectiveness of Melatonin Supplement in the Management of Sleep Disturbances in Children With Atopic Dermatitis[NCT01638234] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts.[NCT04353128] | Phase 2/Phase 3 | 450 participants (Actual) | Interventional | 2020-04-20 | Completed | ||
| The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome[NCT02451293] | Phase 2/Phase 3 | 252 participants (Actual) | Interventional | 2016-01-18 | Completed | ||
| Light Therapy in Parkinson's Disease: a Prospective, Observational Study[NCT06129942] | 50 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | |||
| Dynamic Light Application to Prevent ICU Acquired Delirium[NCT01274819] | 1,000 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| Controlled-Release Melatonin (Melatonin CR)for the Treatment of Impaired Sleep Maintenance (ISM) in 4-8 Year Old Children With Autism Spectrum Disorders (ASD).[NCT01033565] | Phase 4 | 1 participants (Actual) | Interventional | 2010-03-04 | Terminated (stopped due to Unsuccessful in recruiting appropriate subjects.) | ||
| Circadian Health in Patients Admitted to Intensive Care Units and Hospitalization (CHRONOHOSPI)[NCT04113876] | 975 participants (Actual) | Observational [Patient Registry] | 2019-01-01 | Completed | |||
| Effect of Melatonin Supplementation on Sleep and Health of Children With Cerebral Palsy[NCT04392063] | 40 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| A Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Agomelatine in the Prevention of Poststroke Depression[NCT05426304] | Phase 4 | 420 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | ||
| A Randomized, Double-Blind, Placebo-Controlled Trial for the Evaluation of a Food Supplement on Sleep Quality in Primary Insomnia Patient[NCT00484497] | 105 participants (Actual) | Interventional | 2006-09-30 | Completed | |||
| The Light Heart Study: Daily Light Box Use for Depressive Symptoms in Patients With Stage B Heart Failure[NCT02691000] | 122 participants (Anticipated) | Interventional | 2015-09-30 | Recruiting | |||
| High Cortisol Levels as a Risk Factor for Depression in the Elderly and the Effect of Bright Light Treatment on Mood, Sleep-Wake Pattern and Self-Sufficiency[NCT00332670] | Phase 2/Phase 3 | 89 participants (Actual) | Interventional | 2003-01-31 | Terminated (stopped due to End of research time, time-resources) | ||
| Bright Light Therapy Efficacy for Depressive Symptoms Following Cardiac Surgery or Acute Coronary Syndrome: Pilot Trial[NCT02621567] | Phase 4 | 15 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| Prevalence of Epilepsy and Sleep Wake Disorders in Alzheimer Disease[NCT03617497] | 78 participants (Actual) | Interventional | 2020-12-01 | Active, not recruiting | |||
| Sleep Length and Euploid Embryo Transfer Prospective Study[NCT06139757] | 150 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| The Effects Of Kiwifruit Consumption On Sleep Quality, Fatigue And BMI In Saudi Students With Poor Sleep Quality: A 6-Week Pilot Randomized Controlled Trial[NCT05953324] | 26 participants (Actual) | Interventional | 2022-01-01 | Completed | |||
| Melatonin for Neuroprotection Following Perinatal Asphyxia[NCT02071160] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Narcolepsy Protect Against Alzheimer's Disease? Protective Role of Low Rates of Orexin on the Occurrence of Intracerebral Amyloid Deposits Characteristic of the Alzheimer's Disease: A Pilot Study[NCT03378453] | 38 participants (Actual) | Interventional | 2016-04-07 | Completed | |||
| Characterization of Endogenous Melatonin Profiles in Children With Autism Spectrum Disorder.[NCT00691080] | 58 participants (Actual) | Observational | 2007-09-30 | Completed | |||
| Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation[NCT04547439] | Phase 2 | 36 participants (Anticipated) | Interventional | 2021-02-03 | Recruiting | ||
| Restoration of Sleep in Heart Failure Patients[NCT00869869] | Phase 2 | 0 participants (Actual) | Interventional | 2009-03-31 | Withdrawn (stopped due to No subjects were enrolled in this study. Funding ran out.) | ||
| Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309] | Phase 3 | 25 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT[NCT04034771] | Phase 3 | 38 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| The Therapeutic Effect of Melatonin in Pediatric Patients With Functional Dyspepsia[NCT04684199] | 14 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Exploring the Mechanism of a Probiotic Combination VSL#3 in Irritable Bowel Syndrome: a Randomized Double Blind Placebo Controlled Study[NCT00786123] | 40 participants (Anticipated) | Interventional | 2006-05-31 | Completed | |||
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| Melatonin and Ulcerative Colitis: A Pilot Clinical Trial[NCT00790478] | Phase 2 | 3 participants (Actual) | Interventional | 2009-01-31 | Terminated | ||
| Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-03-01 | Terminated (stopped due to PI leaving) | ||
| Prolonged-release Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia: a Randomized Clinical Trial[NCT01431092] | Phase 4 | 86 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Melatonin Studies of Blind Children[NCT00691444] | 10 participants (Actual) | Interventional | 2002-09-30 | Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.) | |||
| Melatonin Levels in Sleep-disordered Smith-Magenis Syndrome: a Pilot Study[NCT00691574] | 5 participants (Actual) | Interventional | 1998-09-30 | Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.) | |||
| [NCT00261183] | Phase 3 | 100 participants | Interventional | 2004-12-31 | Recruiting | ||
| Melatonin Use in the Intensive Care Elderly Population[NCT03013790] | Phase 4 | 600 participants (Anticipated) | Interventional | 2016-12-31 | Recruiting | ||
| Relationship Between Asynchronies and Sleep Disruption in Mechanically Ventilated Patients: a Prospective Cohort Study[NCT05847374] | 50 participants (Actual) | Observational | 2019-01-01 | Completed | |||
| Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation[NCT02464735] | 44 participants (Actual) | Observational | 2016-01-01 | Completed | |||
| Light and Ion Therapy for Seasonal Affective Disorder[NCT00006517] | 150 participants (Actual) | Interventional | 1998-09-30 | Completed | |||
| Testosterone Supplementation and Exercise in Elderly Men[NCT00112151] | Phase 2 | 167 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Identification of Free-Running Rhythms in Blind Children[NCT00688935] | 9 participants (Actual) | Interventional | 2005-01-31 | Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.) | |||
| Does CBT Improve the Effect of Light Therapy in Delayed Sleep Phase Syndrome Compared to Only Light Therapy - Short and Long Term Follow up[NCT01419938] | 57 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Disrupted Sleep in the Elderly: Light Exposure Studies[NCT00427323] | 60 participants (Anticipated) | Interventional | 2006-06-30 | Suspended (stopped due to recruitment has been put on hold until a future date) | |||
| Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic REM Sleep Behavior Disorder: a Pilot Study[NCT02836743] | Phase 4 | 30 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| Efficacy and Tolerability of Ramelteon in Patients With REM Behavior Disorder and Parkinsonism: A Placebo Controlled, Double Blind, Randomized, Prospective Pilot Study[NCT00745030] | 3 participants (Actual) | Interventional | 2008-06-30 | Terminated (stopped due to Low subject recruitment and enrollment.) | |||
| Benefice Assessment of Repetitive Transcranial Magnetic Stimulation Used as an Additional Procedure to Rehabilitation Exercises in Patients Suffering From Fibromyalgia[NCT01308801] | 42 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| Evaluation of Spa Therapy in the Treatment of Fibromyalgia : a Randomized, Controlled, Open Multicenter Study[NCT02265029] | 220 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| A Phase One Treatment Trial of the Circadian Sleep Disturbance in Smith-Magenis Syndrome (SMS)[NCT00506259] | Phase 1 | 23 participants (Actual) | Interventional | 2007-07-17 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
ADAS-cog (Alzheimer's Disease Assessment Scale-cognitive subscale) is a cognitive testing instrument used in clinical trials. It consists of 11 tasks measuring the disturbances of memory, language, praxis, attention, and other cognitive abilities that are often referred to as the core symptoms of AD. The test comprises 11 items summed to a total score ranging from 0 to 70, with lower scores indicating less severe impairment. A negative change indicates an improvement from baseline. ADAS-cog was measured at base line and at end of treatment after 24 weeks. (NCT00940589)
Timeframe: 24 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Circadin | 0.45 |
| Placebo | 0.19 |
Instrumental Activities of Daily Living (iADL). The scale rates activities that represent key life tasks that people need to manage. These tasks are valuable for evaluating persons with early-stage disease, both to assess the level of disease and to determine the person's ability to care for himself or herself. Scores of 0 or 1 are given to every task (Bathing, Dressing, Tolieting, transferring, Continence and Feeding) to a total score of 6. , while 0 represents a patient who is very dependent and 6 represents patient who is independent. iADL was measured at base line and at end of treatment after 24 weeks. (NCT00940589)
Timeframe: 24 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Circadin | 0.77 |
| Placebo | 1.62 |
The Mini Mental State Examination (MMSE) is a brief assessment instrument used to assess cognitive function in elderly patients. The MMSE can be used to screen for cognitive impairment and as a measurement of cognition over time and with pharmacologic treatment. The instrument is divided into 2 sections. The first section measures orientation, memory, and attention: the maximum score is 21. The second section tests the ability of the patient to name objects, follow verbal and written commands, write a sentence, and copy figures: the maximum score is 9. The scoring range for the MMSE is 0-30. Higher score represents better performance. MMSE was measured at base line and at end of treatment after 24 weeks. (NCT00940589)
Timeframe: 24 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Circadin | -0.3 |
| Placebo | -1.9 |
(NCT00626210)
Timeframe: 1 month
| Intervention | hours (Median) |
|---|---|
| Modafinil | 9.5 |
"Sleep efficiency during the down interval. The down interval signifies the period of time (in minutes) at night when subjects are in bed and trying to sleep. Sleep efficiency is calculated as (100*sleep minutes)/[time interval from sleep onset (as defined by the sleep latency) to sleep offset (the end of the last sleep episode in the Down interval)].~The time period was different for each patient, it was their duration of hospitalization. The first 48 hours patients were not on the study drug, so the reported least squares mean is an estimate of the mean for the subsequent time period where the patients received different therapies. These means are corrected for differences that might have existed during the first 48 hours. The results would be similar to the results attained from considering the mean during the first 48 hours as a baseline covariate in an Analysis of Covariance, but would be more robust to missing data." (NCT00814502)
Timeframe: Post-intervention, up to 3 weeks
| Intervention | percentage of sleep (see above) (Least Squares Mean) |
|---|---|
| Zolpidem CR | 75.93 |
| Placebo | 75.30 |
"Total sleep minutes during the down period. The down interval signifies the period of time (in minutes) at night when subjects are in bed and trying to sleep.~The time period was different for each patient, it was their duration of hospitalization. The first 48 hours patients were not on the study drug, so the reported least squares mean is an estimate of the mean for the subsequent time period where the patients received different therapies. These means are corrected for differences that might have existed during the first 48 hours. The results would be similar to the results attained from considering the mean during the first 48 hours as a baseline covariate in an Analysis of Covariance, but would be more robust to missing data." (NCT00814502)
Timeframe: post-intervention, up to 3 weeks
| Intervention | sleep minutes (Least Squares Mean) |
|---|---|
| Zolpidem CR | 443.71 |
| Placebo | 422.49 |
"Rating Scale for Aggressive Behavior in the Elderly (RAGE, 0-61); higher is worse.~Disruptive Behavior Rating Scales (DBRS, 0-105); higher is worse.~Neuropsychiatric Inventory (NPI, 0-144) - measures 12 different domains of neuropsychiatric symptoms such as delusions, hallucinations, anxiety, depression, apathy, etc.; higher is worse.~Montgomery-Asberg Depression Rating Scale (MADRS, 0-90); higher is worse.~Mini-mental state examination (MMSE, 0-30); higher is better.~The time period was different for each patient, it was their duration of hospitalization. The first 48 hours patients were not on the study drug, so the reported least squares mean is an estimate of the mean for the subsequent time period where the patients received different therapies. These means are corrected for differences that might have existed during the first 48 hours. The results would be similar to the results attained from considering the mean during the firs" (NCT00814502)
Timeframe: post-intervention, up to 3 weeks
| Intervention | units on a scale (Least Squares Mean) | ||||
|---|---|---|---|---|---|
| NPI Total Score | RAGE Total Score | DBRS Total Score | MMSE Total Score | MADRS Total Score | |
| Placebo | 18.64 | 5.82 | 22.47 | 21.57 | 22.56 |
| Zolpidem CR | 18.00 | 1.40 | 22.64 | 24.45 | 22.96 |
TST was measured at Baseline and at Week 4 in a sleep laboratory by polysomnography, during an 8-hour recording period beginning at participants' habitual bedtime. (NCT02750306)
Timeframe: Baseline and Week 4
| Intervention | Minutes (Least Squares Mean) |
|---|---|
| Suvorexant | 73.4 |
| Placebo | 45.2 |
WASO was measured at Baseline and at Week 4 in a sleep laboratory by polysomnography during an 8-hour recording period beginning at participants' habitual bedtime. (NCT02750306)
Timeframe: Baseline and Week 4
| Intervention | Minutes (Least Squares Mean) |
|---|---|
| Suvorexant | -45.0 |
| Placebo | -29.4 |
An adverse event (AE) is any untoward medical occurrence in a study participant administered a pharmaceutical product that does not necessarily have to have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign, symptom, or disease temporally associated with the use of a medicinal product, whether or not related to the medicinal product. (NCT02750306)
Timeframe: Up to 4 weeks
| Intervention | Percentage of participants (Number) |
|---|---|
| Suvorexant | 0.7 |
| Placebo | 0.7 |
An adverse event (AE) is any untoward medical occurrence in a study participant administered a pharmaceutical product that does not necessarily have to have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign, symptom, or disease temporally associated with the use of a medicinal product, whether or not related to the medicinal product. (NCT02750306)
Timeframe: Up to 6 weeks
| Intervention | Percentage of participants (Number) |
|---|---|
| Suvorexant | 22.5 |
| Placebo | 16.1 |
Change from baseline in latency of persistent sleep after 4 weeks of treatment, based on participants with valid baseline and week 4 actigraphy data (NCT01548287)
Timeframe: Baseline and Week 4.
| Intervention | Minutes (Least Squares Mean) |
|---|---|
| AZD5213 Dose A | 1.77 |
| AZD5213 Dose B | 9.84 |
| AZD5213 Dose C | -6.85 |
| Placebo | 2.70 |
(NCT01548287)
Timeframe: Baseline and Week 4.
| Intervention | Rank transformed duration (minutes) (Least Squares Mean) |
|---|---|
| AZD5213 Dose A | -2.23 |
| AZD5213 Dose B | 14.48 |
| AZD5213 Dose C | -5.84 |
| Placebo | -5.68 |
Change from baseline in night total sleep time after 4 weeks of treatment: assessed if valid baseline and week 4 actigraphy data (NCT01548287)
Timeframe: Baseline and Week 4.
| Intervention | Minutes (Least Squares Mean) |
|---|---|
| AZD5213 Dose A | 7.07 |
| AZD5213 Dose B | -12.42 |
| AZD5213 Dose C | -18.97 |
| Placebo | -7.51 |
Change from baseline in sleep efficiency after 4 weeks of treatment, based on participants with valid baseline and week 4 actigraphy data (NCT01548287)
Timeframe: Baseline and Week 4.
| Intervention | % (efficiency=% of time asleep) (Least Squares Mean) |
|---|---|
| AZD5213 Dose A | -0.05 |
| AZD5213 Dose B | -3.20 |
| AZD5213 Dose C | -1.92 |
| Placebo | -1.83 |
(NCT01548287)
Timeframe: Baseline and Week 4.
| Intervention | % change (Least Squares Mean) |
|---|---|
| AZD5213 Dose A | 0.08 |
| AZD5213 Dose B | -1.51 |
| AZD5213 Dose C | -2.82 |
| Placebo | 0.96 |
Total sleep time (TST) is defined as the total time in minutes, that subjects were determined to be in a sleep state by polysomnography (PSG) measurement. (NCT01548287)
Timeframe: Baseline and Week 4.
| Intervention | Minutes (Least Squares Mean) |
|---|---|
| AZD5213 Dose A | 6.43 |
| AZD5213 Dose B | -12.53 |
| AZD5213 Dose C | -19.41 |
| Placebo | 14.48 |
Measured as the median of the average WASO of the three weeks of either placebo or ramelteon treatment (NCT00507546)
Timeframe: 10 weeks
| Intervention | Minutes (Median) |
|---|---|
| Ramelteon | 72.3 |
| Placebo | 76.5 |
Measured as the median of the average morning alertness (measured from 1-7 on the Stanford Sleepiness Scale, a Likert-like scale in which higher values are lower alertness) of the three weeks of either placebo or ramelteon treatment (NCT00507546)
Timeframe: 10 weeks
| Intervention | units on a scale (Median) |
|---|---|
| Arm 1 | 2.86 |
| Arm 2 | 3.14 |
"Sleep diary, rise time (when participants rise from bed in the morning, self-report) before and after a randomized controlled 4 armed treatment study including a follow-up 3 months later.~Midnight is 0000; in the outcome measure table the value is given in minutes after midnight.~i.e. 530 equals 08:50 in the morning." (NCT00834886)
Timeframe: 1 day after two-week treatment ends
| Intervention | Minutes (Mean) |
|---|---|
| Combination | 530 |
| Melatonin | 506 |
| Bright Light | 520 |
| Placebo | 543 |
Actigraphy, sleep onset latency (SOL). An actigraph is a wrist-worn movement sensor that objectively record motor activity. Participants used an event button to mark bed time and rise time. The actiwatch is waterproof and participants were instructed not to take it off at any time during the data collection peroid. (NCT00834886)
Timeframe: 1 day after 2-week treatment ended
| Intervention | Minutes (Mean) |
|---|---|
| Combination | 11 |
| Melatonin | 21 |
| Bright Light | 15 |
| Placebo | 24 |
"Subjective sleepiness; Karolinska sleepiness scale (KSS). The KSS is a scale in which the subjects rate their concurrent sleepiness level. The scale is verbally anchored with steps ranging from 1 (very alert) to 9 (very sleepy, fighting sleep, effort to stay awake)." (NCT00834886)
Timeframe: 1 day after 2-week treatment ended
| Intervention | units on a scale (Mean) |
|---|---|
| Combination | 6.0 |
| Melatonin | 5.9 |
| Bright Light | 6.3 |
| Placebo | 6.5 |
Change in mean migraine/migrainous days from weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase for each group. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of single-blind treatment phase to weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | -1 |
| Placebo Oral Capsule | 0 |
Mean CASQ score in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. The CASQ is a 16-question instrument that uses Likert-like responses and has a score range from 16-80; higher scores indicate greater sleepiness (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | points (Mean) |
|---|---|
| Melatonin 3mg | 33 |
| Melatonin 6mg | 36 |
| Placebo Oral Capsule | 28 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 3 mg vs. placebo. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. melatonin 3 mg. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin 6 mg vs. placebo. (Medians reported when data were not normally distributed). (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Mean migraine/migrainous days in weeks 5-8 of randomized treatment phase in melatonin treated participants vs. placebo. (Ultimately, as the data were not normally distributed, medians were more appropriate). (NCT03150797)
Timeframe: weeks 5-8 of randomized treatment phase
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 2 |
| Melatonin 6mg | 2 |
| Placebo Oral Capsule | 2 |
Number of days acute medication is used in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to the number of days that medication for the acute treatment of headache was used during the time frame. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 5 |
| Melatonin 6mg | 3 |
| Placebo Oral Capsule | 3 |
Number of headache days in weeks 5-8 of randomized treatment phase in melatonin treated group vs. placebo, and in each of the three pair-wise group comparisons. This refers to number of headache days during the time period--regardless of whether they were migraine or not. (NCT03150797)
Timeframe: Weeks 5-8 of randomized treatment phase.
| Intervention | days (Median) |
|---|---|
| Melatonin 3mg | 8 |
| Melatonin 6mg | 4 |
| Placebo Oral Capsule | 5 |
Assigns numerical score indicating level of improvement compared to baseline. Scale is rated from 1-7: 1= very much improved; 2= much improved; 3= minimally improved; 4= no change; 5= minimally worse; 6= much worse; 7= very much worse. (NCT01033565)
Timeframe: 2 weeks
| Intervention | units on a scale (Number) |
|---|---|
| Natrol | 2 |
Total change in Fat free mass (kg) as evaluated by DXA (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 0.1 |
| Placebo + PRT | 0.4 |
| Any T + No PRT | 1.0 |
| Any T + PRT | 2.1 |
Total change in Fat mass (kg) as evaluated by DXA (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 0.7 |
| Placebo + PRT | -0.6 |
| Any T + No PRT | -1.0 |
| Any T + PRT | -1.8 |
The maximal weight a participant could lift once [1-repetition maximum, 1-RM] was assessed at baseline and 12 months. The average of the difference from baseline in 3 lower-body 1-RM measures (knee extension, knee flexion, and seated leg press)) are represented. (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 9.4 |
| Placebo + PRT | 27.0 |
| Any T + No PRT | 10.5 |
| Any T + PRT | 28.0 |
Continuous-scale physical function performance test (CS-PFP) which comprises 15 everyday tasks requiring upper and lower body strength and flexibility, balance, coordination and endurance. The CS-PFP was developed to measure performance in higher functioning adults with minimal floor or ceiling effects, and is valid, reliable and sensitive to change. Total and domain scores are scaled from 0 to 100, with higher scores indicating better function. (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo + No PRT | 3.1 |
| Placebo + PRT | 3.6 |
| Any T + No PRT | 0.8 |
| Any T + PRT | 3.3 |
Leg extensor power was evaluated using a Nottingham leg extensor power rig (watts). (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | Watts (Mean) |
|---|---|
| Placebo + No PRT | 4.5 |
| Placebo + PRT | 24.3 |
| Any T + No PRT | 0.8 |
| Any T + PRT | 5.1 |
The maximal weight a participant could lift once (1-repetition maximum, 1-RM) was assessed at baseline and 12 months. The average of the difference from baseline in 4 upper-body 1-RM measures (bench press,incline press, overhead pull-down, and seated row) are represented. (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 4.3 |
| Placebo + PRT | 25.5 |
| Any T + No PRT | 7.8 |
| Any T + PRT | 24.3 |
283 reviews available for melatonin and Sleep Wake Disorders
| Article | Year |
|---|---|
Treatment of Circadian Rhythm Sleep-Wake Disorders.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiation and | 2022 |
Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review.
Topics: Adolescent; Adult; Aged; Brazil; Child; Humans; Melatonin; Sleep; Sleep Initiation and Maintenance D | 2021 |
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer's Disease.
Topics: Alzheimer Disease; Humans; Melatonin; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Wake | 2021 |
What do we really know about the safety and efficacy of melatonin for sleep disorders?
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Initiation and Maintenance Disorders; Sle | 2022 |
[Sleep disorders in patients with a neurocognitive disorder].
Topics: Alzheimer Disease; Chronobiology Disorders; Humans; Melatonin; REM Sleep Behavior Disorder; Restless | 2022 |
Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment.
Topics: Animals; Antidepressive Agents; Antioxidants; Benzofurans; Chronobiology Disorders; Cyclopropanes; D | 2022 |
Melatonin profile in healthy, elderly subjects - A systematic literature review.
Topics: Aged; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2022 |
New Uses of Melatonin as a Drug; A Review.
Topics: Circadian Rhythm; Humans; Melatonin; Receptors, Melatonin; Sleep; Sleep Wake Disorders | 2022 |
Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials.
Topics: Humans; Melatonin; Mental Disorders; Metabolic Diseases; Pain, Postoperative; Randomized Controlled | 2022 |
Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.
Topics: Circadian Rhythm; Humans; Melatonin; Randomized Controlled Trials as Topic; Sleep; Sleep Wake Disord | 2022 |
Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis.
Topics: Bipolar Disorder; Humans; Hypnotics and Sedatives; Mania; Melatonin; Sleep; Sleep Wake Disorders | 2022 |
Melatonin: Translation of Ongoing Studies Into Possible Therapeutic Applications Outside Sleep Disorders.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Wake D | 2022 |
Circadian Rhythm Sleep-Wake Disorders in Older Adults.
Topics: Aged; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Diso | 2022 |
[Chronotherapy of affective disorders: principles and clinical aspects].
Topics: Bipolar Disorder; Chronotherapy; Humans; Melatonin; Mood Disorders; Sleep; Sleep Deprivation; Sleep | 2022 |
Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Topics: Adolescent; Child; Humans; Melatonin; Neurodevelopmental Disorders; Sleep; Sleep Wake Disorders | 2022 |
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review.
Topics: Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Sleep; Sleep Disorder | 2022 |
Melatonin in sleep disorders.
Topics: Humans; Melatonin; Pharmaceutical Preparations; Sleep; Sleep Initiation and Maintenance Disorders; S | 2022 |
Circadian rhythms and disorders of the timing of sleep.
Topics: Biological Factors; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; S | 2022 |
Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness.
Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Circadian Rhythm; Humans; Melatonin | 2022 |
The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review.
Topics: Adolescent; Adult; Anxiety; Brain Injuries, Traumatic; Humans; Melatonin; Sleep; Sleep Wake Disorder | 2023 |
Melatonin for sleep disorders in people with autism: Systematic review and meta-analysis.
Topics: Autism Spectrum Disorder; Autistic Disorder; Humans; Melatonin; Polysomnography; Sleep; Sleep Wake D | 2023 |
Sleep interventions for children with attention deficit hyperactivity disorder (ADHD): A systematic literature review.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Humans; Melatonin; Quality o | 2023 |
Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults.
Topics: Aged; Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Sleep; Sleep Disorders, Circadia | 2023 |
Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis.
Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep Duration; Sleep Initiation and Maintenance | 2023 |
Melatonin use in children and adolescents: A scoping review of caregiver perspectives.
Topics: Adolescent; Caregivers; Child; Comorbidity; Humans; Melatonin; Quality of Life; Sleep; Sleep Wake Di | 2023 |
Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cofilin 1; Cytokines; Disease Models, Animal; Hum | 2019 |
Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders.
Topics: Antidepressive Agents; Antipsychotic Agents; Child; Dietary Supplements; Humans; Hypnotics and Sedat | 2019 |
Dysregulation of Circadian Rhythms in Autism Spectrum Disorders.
Topics: Autism Spectrum Disorder; Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Sleep Wake D | 2019 |
Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review.
Topics: Humans; Melatonin; Randomized Controlled Trials as Topic; Sleep; Sleep Wake Disorders | 2019 |
Chronotype, circadian rhythms and mood.
Topics: Affect; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2020 |
Influence of Dietary Sources of Melatonin on Sleep Quality: A Review.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Dietary Supplements; Female; Hu | 2020 |
Interventions to improve sleep for individuals with Angelman syndrome: A systematic review.
Topics: Angelman Syndrome; Behavior Therapy; Central Nervous System Depressants; Humans; Melatonin; Sleep; S | 2020 |
Understanding the role of sleep and its disturbances in Autism spectrum disorder.
Topics: Autism Spectrum Disorder; Central Nervous System Depressants; Child; Humans; Melatonin; Sleep Wake D | 2020 |
[Melatonin and sleep disorders: Overview of literature and testing in psychiatric practice].
Topics: Humans; Melatonin; Quality of Life; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Wake Di | 2019 |
Systematic review of the efficacy of commonly prescribed pharmacological treatments for primary treatment of sleep disturbance in patients with diagnosed autoimmune disease.
Topics: Autoimmune Diseases; Humans; Melatonin; Polysomnography; Quality of Life; Randomized Controlled Tria | 2020 |
Management of Sleep Disturbances Associated with Smith-Magenis Syndrome.
Topics: Animals; Humans; Melatonin; Mutation; Quality of Life; Sleep; Sleep Wake Disorders; Smith-Magenis Sy | 2020 |
Physiological and pharmacological perspectives of melatonin.
Topics: Circadian Rhythm; Humans; Melatonin; Pineal Gland; Sleep; Sleep Wake Disorders | 2022 |
Sleep in autism: A biomolecular approach to aetiology and treatment.
Topics: Autistic Disorder; Brain; Central Nervous System Depressants; Comorbidity; gamma-Aminobutyric Acid; | 2020 |
Decoding the Inter-Relationship between Sleep Disorders and Alzheimer's Disease Pathogenesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Humans; Melatonin; Neurofibrillary | 2021 |
Angelman syndrome and melatonin: What can they teach us about sleep regulation.
Topics: Angelman Syndrome; Animals; Circadian Rhythm; Humans; Melatonin; Pineal Gland; Sleep Wake Disorders | 2020 |
[Nutrition impact on insomnia treatment].
Topics: Humans; Melatonin; Nutritional Status; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Wake | 2021 |
Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?
Topics: Central Nervous System Depressants; Comorbidity; Humans; Melatonin; Migraine Disorders; Sleep Wake D | 2020 |
Sleep Issues in Parkinson's Disease and Their Management.
Topics: Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Deep Brain Stimulation; Disease Management; | 2020 |
The Treatment of Sleep Dysfunction in Neurodegenerative Disorders.
Topics: Behavior Therapy; Humans; Melatonin; Neurodegenerative Diseases; Quality of Life; Sleep; Sleep Wake | 2021 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyr | 2020 |
Autism Spectrum Disorder and Sleep.
Topics: Adolescent; Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep; Sleep Initiation and Maintena | 2021 |
A practical nutritional guide for the management of sleep disturbances in menopause.
Topics: Adult; Aged; Anxiety; Depression; Diet; Female; Humans; Male; Melatonin; Menopause; Middle Aged; Obe | 2021 |
A critical review of the pharmacological treatment of REM sleep behavior disorder in adults: time for more and larger randomized placebo-controlled trials.
Topics: Aged; Clonazepam; Double-Blind Method; Humans; Melatonin; Randomized Controlled Trials as Topic; REM | 2022 |
Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
Topics: Adult; Dietary Supplements; Humans; Melatonin; Randomized Controlled Trials as Topic; Sleep Quality; | 2022 |
Pharmacokinetics of exogenous melatonin in relation to formulation, and effects on sleep: A systematic review.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2021 |
Endogenous melatonin and sleep in individuals with Rare Genetic Neurodevelopmental Disorders (RGND): A systematic review.
Topics: Humans; Melatonin; Neurodevelopmental Disorders; Sleep; Sleep Wake Disorders; Smith-Magenis Syndrome | 2021 |
Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation.
Topics: Behavior Therapy; Humans; Melatonin; Polysomnography; Sleep; Sleep Wake Disorders | 2021 |
[Sleep disorders in children and adolescents].
Topics: Adolescent; Child; Humans; Melatonin; Sleep; Sleep Hygiene; Sleep Wake Disorders | 2021 |
The efficacy of combined bright light and melatonin therapies on sleep and circadian outcomes: A systematic review.
Topics: Aged; Circadian Rhythm; Humans; Light; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wa | 2021 |
Migraine and Sleep-An Unexplained Association?
Topics: Brain Stem; Cerebral Cortex; Dopamine; Humans; Hypothalamus; Melatonin; Migraine Disorders; Orexins; | 2021 |
Evaluation of Medications Used for Hospitalized Patients With Sleep Disturbances: A Frequency Analysis and Literature Review.
Topics: Adult; Aged; Benzodiazepines; Humans; Hypnotics and Sedatives; Melatonin; Retrospective Studies; Sle | 2023 |
Chronotherapy.
Topics: Chronotherapy; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2021 |
Sleep and liver disease: a bidirectional relationship.
Topics: Body Temperature Regulation; Case-Control Studies; Chronic Disease; Cost of Illness; Disease Progres | 2021 |
Melatonin and Sleep Disturbances in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Circadian Rhythm; Humans; Melatonin; Sleep | 2021 |
Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders.
Topics: COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytokines; Free Radical Scavengers; Humans; Me | 2021 |
A review of sleep disorders and melatonin.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Neurons; Sleep; Sleep Initiation and Maintenance Disor | 2017 |
A review of sleep disorders and melatonin.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Neurons; Sleep; Sleep Initiation and Maintenance Disor | 2017 |
A review of sleep disorders and melatonin.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Neurons; Sleep; Sleep Initiation and Maintenance Disor | 2017 |
A review of sleep disorders and melatonin.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Neurons; Sleep; Sleep Initiation and Maintenance Disor | 2017 |
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.
Topics: Anxiety; Autism Spectrum Disorder; Circadian Clocks; Circadian Rhythm; Fragile X Mental Retardation | 2017 |
Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.
Topics: Humans; Melatonin; Randomized Controlled Trials as Topic; Sleep Disorders, Circadian Rhythm; Sleep W | 2017 |
Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D | 2018 |
The potential influence of LED lighting on mental illness.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Humans; Light; Melatonin; Sleep Wake Disorders | 2018 |
Melatonin, adolescence, and the brain: An insight into the period-specific influences of a multifunctional signaling molecule.
Topics: Adolescent; Adolescent Behavior; Antioxidants; Brain; Circadian Rhythm; Humans; Melatonin; Photoperi | 2017 |
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.
Topics: Animals; Cardiovascular Diseases; Circadian Rhythm; Humans; Melatonin; Nervous System Diseases; Slee | 2018 |
Clinical trials in autism spectrum disorder: evidence, challenges and future directions.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aggression; Antipsychotic Agents; Aripipraz | 2018 |
Sleep disorders during childhood: a practical review.
Topics: Adolescent; Behavior Therapy; Central Nervous System Depressants; Child; Child, Preschool; Humans; I | 2018 |
Managing sleep disturbances in children with atopic dermatitis.
Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Benzodiazepines; Child; Cognitive Behavioral Thera | 2018 |
Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.
Topics: Central Nervous System Depressants; Child; Humans; Melatonin; Models, Statistical; Neurodevelopmenta | 2018 |
Precision medicine in circadian rhythm sleep-wake disorders: current state and future perspectives.
Topics: Circadian Rhythm; Humans; Melatonin; Polysomnography; Precision Medicine; Sleep; Sleep Disorders, Ci | 2017 |
[Melatonin for children with insomnia].
Topics: Adolescent; Central Nervous System Depressants; Child; Child, Preschool; Humans; Melatonin; Puberty; | 2018 |
Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
Topics: Central Nervous System Depressants; Humans; Melatonin; Sleep Stages; Sleep Wake Disorders | 2019 |
Circadian Rhythm Disturbances in the Blind.
Topics: Blindness; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake | 2018 |
Neuroendocrine aspects of improving sleep in epilepsy.
Topics: Animals; Circadian Rhythm; Epilepsy; Humans; Melatonin; Neurosecretory Systems; Receptors, GABA; Sle | 2018 |
Sleep Disorders.
Topics: Central Nervous System Depressants; Central Nervous System Stimulants; Chronobiology Disorders; Cogn | 2019 |
A brief review about melatonin, a pineal hormone.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders | 2018 |
Obesity and sleep disturbance: the chicken or the egg?
Topics: Diet; Endocannabinoids; Energy Metabolism; Exercise; Ghrelin; Humans; Hydrocortisone; Leptin; Melato | 2019 |
Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer's Disease and Melatonin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Humans; Melatonin; | 2019 |
Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbance in children with neurodisabilities: a systematic review.
Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Complementary Therapies; Data Accurac | 2018 |
The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials.
Topics: Central Nervous System Depressants; Cholecystectomy, Laparoscopic; Depression; Dizziness; Headache D | 2019 |
Oral melatonin for non-respiratory sleep disturbance in children with neurodisabilities: systematic review and meta-analyses.
Topics: Actigraphy; Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep Wake Disorders; Treatment Outc | 2019 |
On the Etiopathogenesis and Pathophysiology of Alzheimer's Disease: A Comprehensive Theoretical Review.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Gonadal Steroid Hormones; Humans; Melatonin; Mitochondria; | 2019 |
Pediatric sleep disturbances and treatment with melatonin.
Topics: Child; Child Behavior; Humans; Melatonin; Mental Disorders; Neurodevelopmental Disorders; Sleep Wake | 2019 |
Sleep and Nutrition Interactions: Implications for Athletes.
Topics: Antioxidants; Athletes; Athletic Performance; Circadian Rhythm; Diet; Dietary Carbohydrates; Fruit; | 2019 |
Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD).
Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Disease Models, Animal; Endpoint Determination; | 2020 |
Review of Melatonin Supplementation for Sleep Disorders in Pediatric Special Populations.
Topics: Child; Cross-Over Studies; Dietary Supplements; Humans; Melatonin; Sleep Wake Disorders | 2020 |
Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.
Topics: Adult; Benzofurans; Case-Control Studies; Correlation of Data; Cross-Sectional Studies; Cyclopropane | 2019 |
Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Humans; Hypothalamo-Hypophyseal System; Melatonin; Pain M | 2020 |
Optimal Melatonin Dose in Older Adults: A Clinical Review of the Literature.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2019 |
Sleep and Circadian Rhythmicity in Adult ADHD and the Effect of Stimulants.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Circadian R | 2017 |
Does melatonin affect epileptic seizures?
Topics: Central Nervous System Depressants; Developmental Disabilities; Epilepsy; Humans; Melatonin; Randomi | 2013 |
Meta-analysis: melatonin for the treatment of primary sleep disorders.
Topics: Humans; Melatonin; PubMed; Regression Analysis; Sleep Wake Disorders; Time Factors; Treatment Outcom | 2013 |
Sleep and hormonal changes in aging.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Female; Human Growth Hormone; Humans; Hydrocortisone; H | 2013 |
Delirium: a disturbance of circadian integrity?
Topics: Ataxia; Chronobiology Disorders; Cognition Disorders; Delirium; Humans; Melatonin; Models, Biologica | 2013 |
Melatonin in autism spectrum disorders.
Topics: Animals; Child; Child Development Disorders, Pervasive; Circadian Rhythm; Humans; Melatonin; Sleep; | 2014 |
Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: evidence from a systematic review.
Topics: Adolescent; Brain Injuries; Central Nervous System Depressants; Child; Child, Preschool; Humans; Mel | 2014 |
The circadian rhythm in adult attention-deficit/hyperactivity disorder: current state of affairs.
Topics: Adult; Attention; Attention Deficit Disorder with Hyperactivity; Circadian Rhythm; Humans; Melatonin | 2013 |
Pathophysiological background and clinical characteristics of sleep disorders in multiple sclerosis.
Topics: Animals; Fatigue; Humans; Melatonin; Multiple Sclerosis; Narcolepsy; Restless Legs Syndrome; Sleep W | 2013 |
Melatonin: an option for managing sleep disorders in children with autism spectrum disorder.
Topics: Adolescent; Chemistry, Pharmaceutical; Child; Child Development Disorders, Pervasive; Child, Prescho | 2014 |
[Melatonin as a drug: present-day status and prospects].
Topics: Animals; Antioxidants; Circadian Rhythm; Drug Administration Schedule; Drug Synergism; Humans; Melat | 2013 |
[Circadian rhythm and inflammatory bowel disease].
Topics: Animals; Chronotherapy; Circadian Rhythm; Disease Models, Animal; Humans; Inflammatory Bowel Disease | 2013 |
[Autism spectrum disorders].
Topics: Child Development Disorders, Pervasive; Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders; W | 2013 |
Pharmacotherapies for sleep disturbances in Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic; Sleep; Sleep W | 2014 |
Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review.
Topics: Adult; Aged; Blood Pressure; Body Temperature; Circadian Rhythm; Craniopharyngioma; Fatigue; Female; | 2014 |
Light exposure at night, sleep duration, melatonin, and breast cancer: a dose-response analysis of observational studies.
Topics: Breast Neoplasms; Environmental Exposure; Female; Humans; Light; Melatonin; Risk Factors; Sleep; Sle | 2014 |
Therapeutic effects of melatonin receptor agonists on sleep and comorbid disorders.
Topics: Acetamides; Animals; Benzofurans; Clinical Trials as Topic; Cyclopropanes; Humans; Hypnotics and Sed | 2014 |
Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials.
Topics: Alzheimer Disease; Central Nervous System Depressants; Cognition; Cognition Disorders; Dementia; Dem | 2015 |
Potential safety issues in the use of the hormone melatonin in paediatrics.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Melatonin; Patient Safety; Sleep; Sle | 2015 |
[Sleep problems in dementia].
Topics: Aged; Aged, 80 and over; Aging; Chronobiology Disorders; Circadian Rhythm; Dementia; Humans; Melaton | 2014 |
Sleep-related behaviors in Alzheimer's disease and dementia with Lewy bodies.
Topics: Alzheimer Disease; Animals; Behavior; Humans; Lewy Body Disease; Melatonin; Sleep; Sleep Wake Disord | 2015 |
Sleep disruption and the sequelae associated with traumatic brain injury.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain Injuries; Cogniti | 2015 |
Melatonin in aging women.
Topics: Aging; Animals; Carbohydrate Metabolism; Female; Humans; Lipid Metabolism; Melatonin; Menopause; Neo | 2015 |
Melatonin Treatment in Children with Developmental Disabilities.
Topics: Child; Developmental Disabilities; Humans; Hypnotics and Sedatives; Melatonin; Randomized Controlled | 2015 |
[Circadian rhythm sleep-wake disorder (circadian rhythm sleep disorder)].
Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Sleep; Sleep Wake Disorders; Treatment Outcome | 2015 |
Circadian dysrhythmias in the intensive care unit.
Topics: Central Nervous System Depressants; Chronobiology Disorders; Critical Illness; Humans; Intensive Car | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Neurodegenerative Diseases; Randomized Controlled Trials | 2016 |
Effects of artificial light at night on human health: A literature review of observational and experimental studies applied to exposure assessment.
Topics: Breast Neoplasms; Circadian Clocks; Circadian Rhythm; Female; Humans; Lighting; Male; Melatonin; Neo | 2015 |
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.
Topics: Animals; Circadian Rhythm; Humans; Ligands; Melatonin; Neoplasms; Receptor, Melatonin, MT1; Receptor | 2016 |
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.
Topics: Animals; Circadian Rhythm; Humans; Ligands; Melatonin; Neoplasms; Receptor, Melatonin, MT1; Receptor | 2016 |
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.
Topics: Animals; Circadian Rhythm; Humans; Ligands; Melatonin; Neoplasms; Receptor, Melatonin, MT1; Receptor | 2016 |
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.
Topics: Animals; Circadian Rhythm; Humans; Ligands; Melatonin; Neoplasms; Receptor, Melatonin, MT1; Receptor | 2016 |
Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin.
Topics: Child; Circadian Rhythm; Cytokines; Dermatitis, Atopic; Humans; Lymphocytes; Melatonin; Sleep Wake D | 2016 |
Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases.
Topics: Central Nervous System Depressants; Humans; Melatonin; Neurodegenerative Diseases; Sleep Wake Disord | 2016 |
Physiological melatonin levels in healthy older people: A systematic review.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Dementia; Dietary Supplements; Female; Health Stat | 2016 |
Circadian rhythm and menopause.
Topics: Aging; Circadian Rhythm; Female; Hot Flashes; Humans; Melatonin; Menopause; Middle Aged; Sex Charact | 2016 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic; Sleep; Sleep W | 2016 |
Sleep and Neurodegeneration: A Critical Appraisal.
Topics: Alzheimer Disease; Dementia; Humans; Lewy Body Disease; Melatonin; Multiple System Atrophy; Neurodeg | 2017 |
Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.
Topics: Benzofurans; Blindness; Circadian Clocks; Cyclopropanes; Humans; Melatonin; Sleep Wake Disorders | 2017 |
Effectiveness of Sleep-Based Interventions for Children with Autism Spectrum Disorder: A Meta-Synthesis.
Topics: Autism Spectrum Disorder; Behavior Therapy; Child; Early Medical Intervention; Humans; Melatonin; Sl | 2017 |
When to use drugs to help sleep.
Topics: Child; Humans; Hypnotics and Sedatives; Melatonin; Narcolepsy; Parasomnias; Sleep Initiation and Mai | 2008 |
Suprachiasmatic nucleus and melatonin: reciprocal interactions and clinical correlations.
Topics: Aging; Alzheimer Disease; Animals; Circadian Rhythm; Humans; Melatonin; Pineal Gland; Sleep Wake Dis | 2008 |
Assessment and pharmacologic treatment of sleep disturbance in autism.
Topics: Adolescent; Autistic Disorder; Child; Comorbidity; Humans; Hypnotics and Sedatives; Melatonin; Psych | 2008 |
Pathophysiology of depression: role of sleep and the melatonergic system.
Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Depression; Humans; Melatonin; Prevalence; Rece | 2009 |
[Diagnosis and treatment of sleep disorders].
Topics: Antidepressive Agents; Humans; Hypnotics and Sedatives; Melatonin; Psychotherapy; Sleep Initiation a | 2009 |
Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis.
Topics: Angelman Syndrome; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2009 |
Sleep disorders in children.
Topics: Administration, Oral; Behavior Therapy; Child; Humans; Learning Disabilities; Melatonin; Parasomnias | 2007 |
Bidirectional communication between sleep and circadian rhythms and its implications for depression: lessons from agomelatine.
Topics: Acetamides; Animals; Brain; Chronobiology Disorders; Circadian Rhythm; Depressive Disorder, Major; H | 2009 |
Complementary, holistic, and integrative medicine: melatonin.
Topics: Adolescent; Age Factors; Central Nervous System Depressants; Child; Child, Preschool; Clinical Trial | 2009 |
GABA(B) receptors, schizophrenia and sleep dysfunction: a review of the relationship and its potential clinical and therapeutic implications.
Topics: Animals; Antipsychotic Agents; Benzhydryl Compounds; Central Nervous System Depressants; Central Ner | 2009 |
[Depression as chronobiological illness].
Topics: Acetamides; Affect; Biological Clocks; Chronotherapy; Circadian Rhythm; Depression; Depressive Disor | 2009 |
Melatonin, circadian rhythms, and the clock genes in bipolar disorder.
Topics: Bipolar Disorder; Circadian Rhythm; CLOCK Proteins; Humans; Melatonin; Sleep Wake Disorders | 2009 |
Agomelatine: a novel pharmacological approach to treating depression.
Topics: Acetamides; Animals; Antidepressive Agents; Anxiety; Depressive Disorder, Major; Drug Interactions; | 2009 |
Measures to counteract the negative effects of night work.
Topics: Humans; Light; Melatonin; Sleep Wake Disorders; Work Schedule Tolerance | 2010 |
Non-pharmacologic management of sleep disturbance in Alzheimer's disease.
Topics: Actigraphy; Alzheimer Disease; Angiotensin-Converting Enzyme Inhibitors; Cognitive Behavioral Therap | 2010 |
Circadian rhythm sleep disorders.
Topics: Biological Clocks; Circadian Rhythm; Guidelines as Topic; Humans; Jet Lag Syndrome; Melatonin; Polys | 2010 |
Impact of the novel antidepressant agomelatine on disturbed sleep-wake cycles in depressed patients.
Topics: Acetamides; Animals; Antidepressive Agents; Depressive Disorder, Major; Humans; Melatonin; Randomize | 2010 |
Circadian rhythms and depression.
Topics: Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Family Practice; Female; Humans; Incid | 2010 |
Sleep in children with autistic spectrum disorder.
Topics: Child; Child Development Disorders, Pervasive; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2010 |
Circadian aspects of post-operative morbidity and mortality.
Topics: Autonomic Nervous System; Circadian Rhythm; Humans; Hydrocortisone; Melatonin; Pharmacokinetics; Pos | 2010 |
Sleep problems in the child with attention-deficit hyperactivity disorder: defining aetiology and appropriate treatments.
Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Beh | 2010 |
Sleep health and asynchronization.
Topics: Biological Clocks; Circadian Rhythm; Cortical Synchronization; Health; Humans; Japan; Melatonin; Ser | 2011 |
Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?
Topics: Animals; Circadian Clocks; Circadian Rhythm; Colitis, Ulcerative; Crohn Disease; Humans; Inflammator | 2011 |
Pharmacotherapy in pediatric sleep disorders.
Topics: Adolescent; Central Nervous System Depressants; Child; GABA-A Receptor Agonists; Histamine Antagonis | 2010 |
Melatonin in children with autistic spectrum disorders: recent and practical data.
Topics: Child; Child Development Disorders, Pervasive; Humans; Melatonin; Sleep Wake Disorders | 2011 |
Melatonin for disordered sleep in individuals with autism spectrum disorders: systematic review and discussion.
Topics: Adolescent; Adult; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2011 |
Sleep disorders in children.
Topics: 5-Hydroxytryptophan; Child; Humans; Learning Disabilities; Melatonin; Parasomnias; Sleep; Sleep Wake | 2010 |
Sleep disturbances in people with epilepsy; prevalence, impact and treatment.
Topics: Adolescent; Adult; Central Nervous System Depressants; Child; Epilepsy; Female; Humans; Male; Melato | 2011 |
Therapeutic options in the management of sleep disorders in visually impaired children: a systematic review.
Topics: Behavior Therapy; Central Nervous System Depressants; Child; Circadian Rhythm; Humans; Hypnotics and | 2011 |
Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin.
Topics: Animals; Antioxidants; Chronobiology Phenomena; Circadian Rhythm; Cytoprotection; Humans; Melatonin; | 2011 |
Melatonin utility in neonates and children.
Topics: Antioxidants; Child; Female; Fetal Growth Retardation; Humans; Hypoxia-Ischemia, Brain; Infant, Newb | 2012 |
Sleep disturbances in critically ill patients in ICU: how much do we know?
Topics: Adult; Aged; Critical Care; Critical Illness; Drug-Related Side Effects and Adverse Reactions; Femal | 2012 |
Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: focus on the role of hypocretin and melatonin.
Topics: Alzheimer Disease; Circadian Rhythm; Humans; Intracellular Signaling Peptides and Proteins; Melatoni | 2013 |
Interventions with a sleep outcome for children with cerebral palsy or a post-traumatic brain injury: a systematic review.
Topics: Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Humans; Hypnotics and Sedatives; Infant; Me | 2012 |
The role of melatonin treatment in chronic kidney disease.
Topics: Blood Pressure; Chronobiology Disorders; Chronotherapy; Humans; Inflammation Mediators; Kidney Failu | 2012 |
Interacting epidemics? Sleep curtailment, insulin resistance, and obesity.
Topics: Adiponectin; Appetite; Diabetes Mellitus; Energy Metabolism; Female; Ghrelin; Glucose; Humans; Insul | 2012 |
[Sleep disorder and hypertension].
Topics: Circadian Rhythm; Habits; Humans; Hypertension; Melatonin; Sleep; Sleep Wake Disorders | 2012 |
Agomelatine in depressive disorders: its novel mechanisms of action.
Topics: Acetamides; Animals; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Disease Models, | 2012 |
Pediatric sleep pharmacology.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Child; Child, Preschool; Clonidine; Contraindicat | 2012 |
Sleep and circadian rhythm dysregulation in schizophrenia.
Topics: Antipsychotic Agents; Chronic Disease; Circadian Rhythm; Humans; Melatonin; Schizophrenia; Schizophr | 2013 |
[Sleep disorders among adolescents--a major problem in mental health care].
Topics: Adolescent; Behavior Therapy; Central Nervous System Depressants; Counseling; Female; Humans; Male; | 2012 |
[Sleep and breast cancer: is there a link?].
Topics: Breast Neoplasms; Female; Humans; Melatonin; Risk Factors; Sleep; Sleep Wake Disorders | 2013 |
Is melatonin likely to help children with neurodevelopmental disability and chronic severe sleep problems?
Topics: Child, Preschool; Chronic Disease; Developmental Disabilities; Female; Humans; Learning Disabilities | 2002 |
[Melatonin and epilepsy].
Topics: Anticonvulsants; Circadian Rhythm; Electroencephalography; Epilepsy; Humans; Light; Melatonin; Neuro | 2002 |
Sleep-related epilepsy.
Topics: Anticonvulsants; Electric Stimulation Therapy; Electroencephalography; Epilepsy; Humans; Melatonin; | 2003 |
Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary.
Topics: Child; Developmental Disabilities; Dietary Supplements; Humans; Melatonin; Sleep Wake Disorders | 2003 |
[Melatonin. A clinical-pharmacological assessment].
Topics: Aged; Animals; Antioxidants; Dietary Supplements; Drug Interactions; Humans; Melatonin; Mental Disor | 2004 |
Pediatric sleep pharmacology: you want to give my kid sleeping pills?
Topics: Benzodiazepines; Dopamine Agents; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Melaton | 2004 |
The role of chronobiology in sleep disorders medicine.
Topics: Chronobiology Phenomena; Circadian Rhythm; Electroencephalography; Humans; Melatonin; Polysomnograph | 2003 |
Circadian rhythm sleep disorders.
Topics: Body Temperature; Chronobiology Disorders; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Photo | 2004 |
Sleep disorders in Alzheimer's disease and other dementias.
Topics: Accidental Falls; Alzheimer Disease; Antipsychotic Agents; Body Temperature Regulation; Chronobiolog | 2004 |
The therapeutic potential of melatonin: a review of the science.
Topics: Aging; Animals; Antioxidants; Endocrine System Diseases; Humans; Melatonin; Mental Disorders; Neopla | 2004 |
Sleep disorders, epilepsy, and autism.
Topics: Antioxidants; Autistic Disorder; Child; Circadian Rhythm; Epilepsy; Humans; Melatonin; Polysomnograp | 2004 |
Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment.
Topics: Antioxidants; Brain; Child; Developmental Disabilities; Humans; Melatonin; Sleep Wake Disorders; Wak | 2004 |
Melatonin for treatment of sleep disorders.
Topics: Adult; Humans; Melatonin; Sleep; Sleep Deprivation; Sleep Initiation and Maintenance Disorders; Slee | 2004 |
Melatonin, sleep, and circadian rhythms.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders; Species Specificity; Supr | 2005 |
Sports chronobiology consultation: from the lab to the arena.
Topics: Altitude; Biological Clocks; Central Nervous System Stimulants; Chronobiology Phenomena; Circadian R | 2005 |
Sleep and childhood epilepsy.
Topics: Anticonvulsants; Child; Cognition; Electroencephalography; Epilepsy; Humans; Melatonin; Sleep; Sleep | 2005 |
Melatonin and sleep in aging population.
Topics: Aged; Aging; Alzheimer Disease; Body Temperature Regulation; Female; Humans; Indenes; Indoles; Male; | 2005 |
The human circadian system in normal and disordered sleep.
Topics: Biological Clocks; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Receptors, Melatoni | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Treatment Outcome | 2005 |
[Melatonin: what for?].
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Neoplasms; Sleep Wake Disorders | 2005 |
The trajectory of biomarkers in symptom management for older adults with cancer.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aged; Aging; Anxiety; Biomarkers; Biomarkers, Tumor; Cy | 2006 |
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mel | 2006 |
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mel | 2006 |
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mel | 2006 |
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mel | 2006 |
Circadian uses of melatonin in humans.
Topics: Blindness; Circadian Rhythm; Humans; Melatonin; Periodicity; Seasonal Affective Disorder; Seasons; S | 2006 |
Drugs for sleep disorders: mechanisms and therapeutic prospects.
Topics: Adenosine; Arousal; Dopamine Agents; Humans; Hypnotics and Sedatives; Melatonin; Receptors, GABA; Re | 2006 |
Management of sleep disturbance associated with atopic dermatitis.
Topics: Algorithms; Clonidine; Dermatitis, Atopic; Doxepin; Histamine H1 Antagonists; Humans; Hypnotics and | 2006 |
Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment.
Topics: Abnormalities, Multiple; Circadian Rhythm; Humans; Intellectual Disability; Melatonin; Sleep Wake Di | 2006 |
Sleep disturbances in the disabled child--a case report and literature review.
Topics: Anticonvulsants; Behavior Therapy; Child; Chromosome Disorders; Disabled Children; Dose-Response Rel | 2006 |
The brain's master circadian clock: implications and opportunities for therapy of sleep disorders.
Topics: Antioxidants; Body Temperature; Circadian Rhythm; Humans; Hypothalamus; Melatonin; Phototherapy; Pit | 2007 |
Sleep and vascular disorders.
Topics: Animals; Humans; Melatonin; Rats; Sleep Wake Disorders; Sympathetic Nervous System; Vascular Disease | 2006 |
[Melatonin: physiological and pathophysiological aspects and possible applications].
Topics: Blood Pressure; Circadian Rhythm; Humans; Melatonin; Pineal Gland; Sleep Wake Disorders; Travel | 2006 |
[Sleep disorders. Melatonin in multiple indications is infective].
Topics: Humans; Melatonin; Sleep Wake Disorders | 2006 |
Sleep in schizophrenia: impairments, correlates, and treatment.
Topics: Antioxidants; Antipsychotic Agents; Humans; Melatonin; Schizophrenia; Sleep Wake Disorders | 2006 |
The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma.
Topics: Craniocerebral Trauma; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Hum | 2007 |
Melatonin as pharmacologic support in burn patients: a proposed solution to thermal injury-related lymphocytopenia and oxidative damage.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxid | 2007 |
Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Biological Clocks; Circadian Rhythm; Disease Progression; Humans; Melatoni | 2007 |
Sleep and aging: 2. Management of sleep disorders in older people.
Topics: Adjuvants, Immunologic; Aged; Aging; Antidepressive Agents; Behavior Therapy; Benzodiazepines; Demen | 2007 |
[Melatonin, melatonin receptor agonists and tryptophan as sleep aids].
Topics: Acetamides; Animals; Antioxidants; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Receptors, M | 2007 |
Nocturnal itch: why do we itch at night?
Topics: Adjuvants, Immunologic; Autonomic Nervous System; Circadian Rhythm; Cytokines; Emollients; Histamine | 2007 |
New perspectives for the treatment of disorders of sleep and arousal.
Topics: Arousal; Central Nervous System Stimulants; Circadian Rhythm; Humans; Melatonin; Receptors, GABA-A; | 2007 |
Melatonin.
Topics: Animals; Humans; Melatonin; Sleep Wake Disorders; Tinnitus | 2007 |
Role of the melatonin system in the control of sleep: therapeutic implications.
Topics: Animals; Humans; Melatonin; Receptors, Melatonin; Sleep; Sleep Wake Disorders | 2007 |
Complementary and alternative medicine for sleep disturbances in older adults.
Topics: Acupressure; Aged; Animals; Circadian Rhythm; Complementary Therapies; Humans; Meditation; Melatonin | 2008 |
Does melatonin play a role in aging processes?
Topics: Aged; Aging; Antioxidants; Circadian Rhythm; Free Radicals; Humans; Immune System; Melatonin; Pineal | 2007 |
In search of novel and therapeutically significant melatoninergic ligands.
Topics: Animals; Biomedical Research; Circadian Rhythm; Humans; Ligands; Melatonin; Receptors, Melatonin; Sl | 2007 |
Sleep and circadian rhythms in humans.
Topics: Automobile Driving; Circadian Rhythm; Homeostasis; Humans; Melatonin; Photobiology; Photoperiod; Sle | 2007 |
The possible interplay of synaptic and clock genes in autism spectrum disorders.
Topics: Autistic Disorder; Carrier Proteins; Cell Adhesion Molecules, Neuronal; Child; Circadian Rhythm; Fem | 2007 |
Sleep in the intensive care unit.
Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score | 2008 |
Sleep in the intensive care unit.
Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score | 2008 |
Sleep in the intensive care unit.
Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score | 2008 |
Sleep in the intensive care unit.
Topics: Circadian Rhythm; Delirium; Humans; Hypnotics and Sedatives; Immunocompetence; Injury Severity Score | 2008 |
Human body clocks and the timing of sleep.
Topics: Aerospace Medicine; Biological Clocks; Bipolar Disorder; Humans; Light; Melatonin; Models, Biologica | 1982 |
Circadian timing of sleepiness in man and woman.
Topics: Body Temperature; Central Nervous System; Circadian Rhythm; Depression; Female; Humans; Male; Melato | 1982 |
Light treatment for sleep disorders: consensus report. I. Chronology of seminal studies in humans.
Topics: Brain; Circadian Rhythm; Humans; Melatonin; Phototherapy; Sleep Wake Disorders | 1995 |
Light treatment for sleep disorders: consensus report. II. Basic properties of circadian physiology and sleep regulation.
Topics: Body Temperature; Brain; Circadian Rhythm; Electroencephalography; Homeostasis; Humans; Melatonin; N | 1995 |
Light treatment for sleep disorders: consensus report. III. Alerting and activating effects.
Topics: Arousal; Body Temperature; Circadian Rhythm; Electroencephalography; Galvanic Skin Response; Humans; | 1995 |
Light treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances.
Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Sleep Stages; Sleep | 1995 |
[Role of biological clock in human pathology].
Topics: Biological Clocks; Circadian Rhythm; Humans; Melatonin; Phototherapy; Pineal Gland; Sleep Wake Disor | 1995 |
Melatonin comes of age?
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Receptors, Cell Surface; Receptors, Melatonin; | 1995 |
Treatment of delayed sleep phase syndrome.
Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Hypnotics and Sedatives; Male; Melatonin; Middl | 1995 |
[Therapy of jet lag].
Topics: Arousal; Attention; Circadian Rhythm; Drug Administration Schedule; Humans; Melatonin; Phototherapy; | 1995 |
Chronobiotics--drugs that shift rhythms.
Topics: Chronobiology Phenomena; Circadian Rhythm; Drug Delivery Systems; Feedback; Humans; Melatonin; Perio | 1996 |
Use of melatonin in the treatment of paediatric sleep disorders.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Disabled Persons; | 1996 |
Melatonin supplements for aging.
Topics: Aged; Aging; Animals; Circadian Rhythm; Depression; Electromagnetic Fields; Feedback; Humans; Melato | 1996 |
[Effect of biological rhythm on sleep-wakefulness regulation].
Topics: Circadian Rhythm; Humans; Melatonin; Polysomnography; Sleep Stages; Sleep Wake Disorders; Suprachias | 1996 |
Melatonin: media hype or therapeutic breakthrough?
Topics: Aging; Circadian Rhythm; Drug Interactions; Humans; Melatonin; Primary Prevention; Sleep Wake Disord | 1997 |
Treatment of circadian rhythm disorders--melatonin.
Topics: Adult; Aerospace Medicine; Aircraft; Animals; Circadian Rhythm; Darkness; Female; Humans; Light; Mel | 1997 |
Sleep disorders and aging: understanding the causes.
Topics: Aging; Circadian Rhythm; Health Status; Humans; Hypnotics and Sedatives; Melatonin; Mental Health; S | 1997 |
Melatonin: therapeutic use in sleep disorders.
Topics: Adult; Aged; Central Nervous System Diseases; Circadian Rhythm; Female; Humans; Male; Melatonin; Mid | 1997 |
Melatonin--a possible link between sleep and the immune system.
Topics: Aged; Animals; Antibody Formation; Antioxidants; Circadian Rhythm; Humans; Immunity, Cellular; Melat | 1997 |
Resolution of sleep paralysis by weak electromagnetic fields in a patient with multiple sclerosis.
Topics: Adult; Circadian Rhythm; Electromagnetic Fields; Female; Humans; Melatonin; Multiple Sclerosis; Para | 1997 |
Melatonin: pathway from obscure molecule to international fame.
Topics: Animals; Antioxidants; Biological Clocks; Circadian Rhythm; Free Radical Scavengers; Humans; Legisla | 1997 |
Melatonin: a sleep-promoting hormone.
Topics: Adult; Aged; Child; Child, Preschool; Circadian Rhythm; Dose-Response Relationship, Drug; Humans; Hy | 1997 |
[Role of the pharmacopoeia in the prevention of jet-lag].
Topics: Caffeine; Central Nervous System Stimulants; Chronotherapy; Circadian Rhythm; Humans; Hypnotics and | 1997 |
[Jet lag syndrome].
Topics: Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Phototherapy; Sleep Wake Disorders; Sy | 1998 |
[Advanced sleep phase syndrome (ASPS) and delayed sleep phase syndrome (DSPS)].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Chronotherapy; Circadian Rhythm; Humans; Melatonin; P | 1998 |
[Non-24-hour sleep-wake syndrome].
Topics: Chronotherapy; Circadian Rhythm; Humans; Melatonin; Phototherapy; Sleep Wake Disorders; Syndrome; Ti | 1998 |
Therapeutic applications of melatonin and related compounds.
Topics: Animals; Humans; Melatonin; Sleep Wake Disorders | 1998 |
Sleep and circadian disturbances in shift work: strategies for their management.
Topics: Adaptation, Psychological; Circadian Rhythm; Exercise; Humans; Hypnotics and Sedatives; Lighting; Me | 1998 |
Use of melatonin for sleep and circadian rhythm disorders.
Topics: Aged; Animals; Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders; Suprachiasmatic Nucleus; T | 1998 |
Guidelines for prescribing melatonin.
Topics: Aged; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Drug Administration Schedule; Female; | 1998 |
Disorders of the sleep-wake cycle in adults.
Topics: Adult; Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Sleep Initiat | 1998 |
[Melatonin: a popular hormone].
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Animals; Child; Child, Preschool; Circadian Rhythm; Con | 1998 |
Sleep disorders in the elderly.
Topics: Aged; Antidepressive Agents; Benzodiazepines; Comorbidity; Humans; Life Expectancy; Melatonin; Menta | 1999 |
Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps.
Topics: Adolescent; Adult; Behavior Therapy; Child; Chronotherapy; Developmental Disabilities; Female; Human | 1999 |
Melatonin, biological rhythm disorders and phototherapy.
Topics: Body Fluids; Circadian Rhythm; Humans; Hypothalamus; Melatonin; Mood Disorders; Neurotransmitter Age | 1997 |
Melatonin. Pineal gland hormone--a brief review.
Topics: Adult; Female; Humans; Male; Melatonin; Pineal Gland; Sleep; Sleep Wake Disorders | 1998 |
Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics.
Topics: Adult; Aged; Aging; Circadian Rhythm; Electroencephalography; Humans; Male; Melatonin; Sleep; Sleep | 1999 |
Melatonin treatment of non-epileptic myoclonus in children.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Male; Melatonin; Myoclonus; Sleep | 1999 |
Sex, steroids, and sleep: a review.
Topics: Animals; Depressive Disorder; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Hyp | 1999 |
Melatonin treatment of sleep-wake cycle disorders in children and adolescents.
Topics: Adolescent; Child; Circadian Rhythm; Female; Free Radical Scavengers; Humans; Male; Melatonin; Sleep | 1999 |
[Melatonin and sleep disorders].
Topics: Circadian Rhythm; Humans; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Re | 1999 |
The use of melatonin: an information paper.
Topics: Circadian Rhythm; Humans; Melatonin; Military Personnel; Sleep; Sleep Wake Disorders; Task Performan | 2000 |
Use of melatonin in the treatment of phase shift and sleep disorders.
Topics: Blindness; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep Wake Disorders; Work Schedul | 1999 |
Nocturnal melatonin secretion and its modification by treatment in patients with sleep disorders.
Topics: Adult; Circadian Rhythm; Doxepin; Flunitrazepam; Humans; Hypnotics and Sedatives; Melatonin; Middle | 1999 |
Melatonin as a chronobiotic for circadian insomnia. Clinical observations and animal models.
Topics: Adolescent; Adult; Age Factors; Aged; Animals; Child; Chronobiology Phenomena; Circadian Rhythm; Hum | 1999 |
The therapeutics of melatonin: a paediatric perspective.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Melatonin; Sleep Wake Disorders | 2000 |
Alterations with aging of the endocrine and neuroendocrine circadian system in humans.
Topics: Aged; Aging; Body Temperature; Calcitonin; Catecholamines; Circadian Rhythm; Electrolytes; Female; G | 2000 |
Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons.
Topics: Aged; Circadian Rhythm; Dementia; Humans; Institutionalization; Melatonin; Neurosecretory Systems; P | 2000 |
Melatonin: interesting, but not miraculous.
Topics: Adjuvants, Immunologic; Advertising; Circadian Rhythm; Clinical Trials as Topic; Dietary Supplements | 1998 |
Melatonin and development: physiology and pharmacology.
Topics: Adolescent; Adult; Aging; Child; Circadian Rhythm; Female; Fetus; Humans; Infant; Melatonin; Pregnan | 2000 |
[Melatonin. II. Physiological and therapeutic effects].
Topics: Anticarcinogenic Agents; Antioxidants; Chronobiology Phenomena; Circadian Rhythm; Humans; Jet Lag Sy | 2000 |
In what circumstances is melatonin a useful sleep therapy? Consensus statement, WFSRS focus group, Dresden, November 1999.
Topics: Antioxidants; Germany; Humans; Melatonin; Sleep Wake Disorders | 2000 |
[Melatonin: is there a rationale for the clinical use of this hormone in sleep therapy?].
Topics: Animals; Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders | 2001 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
[Sleep in fibromyalgia: review of clinical and polysomnographic data].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Arousal; Circadian Rhythm; Depression; Female; Fib | 2001 |
Current understanding of the circadian clock and the clinical implications for neurological disorders.
Topics: Animals; Biological Clocks; Circadian Rhythm; Humans; Melatonin; Nervous System Diseases; Neurons; S | 2001 |
[Alcohol, chronobiology and sleep].
Topics: Alcoholism; Animals; Chronobiology Disorders; Ethanol; Humans; Melatonin; Sleep Wake Disorders | 2001 |
Sleep disorders in children with neurologic diseases.
Topics: Anticonvulsants; Blindness; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Headache; Hu | 2001 |
Melatonin deficiencies in women.
Topics: Breast Neoplasms; Circadian Rhythm; Depression; Female; Humans; Jet Lag Syndrome; Melatonin; Menopau | 2002 |
Circadian Rhythm Sleep Disorders (CRSD) in psychiatry--a review.
Topics: Antipsychotic Agents; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Phototherapy; Selective | 2002 |
The use of melatonin in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antioxidants; Circadian Rhythm; Clinical Trials as Topic; Humans; Melatonin | 2002 |
Future of melatonin as a therapeutic agent.
Topics: Animals; Contraindications; Free Radical Scavengers; Humans; Melatonin; Sleep Wake Disorders | 2002 |
Senescence, sleep, and circadian rhythms.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2002 |
[Melatonin treatment of sleep disorders in children].
Topics: Antioxidants; Child; Child Welfare; Circadian Rhythm; Drug Administration Schedule; Humans; Melatoni | 2002 |
[Shift work, jet lag and sleep].
Topics: Circadian Rhythm; Environment; Humans; Melatonin; Sleep Wake Disorders; Travel; Work Schedule Tolera | 1991 |
The pineal gland: anatomy, physiology, and clinical significance.
Topics: Analgesia; Animals; Brain Neoplasms; Circadian Rhythm; Depression; Electroencephalography; Humans; H | 1985 |
111 trials available for melatonin and Sleep Wake Disorders
| Article | Year |
|---|---|
[Therapeutic approaches for sleep and rhythms disorders in children with ASD].
Topics: Adolescent; Autism Spectrum Disorder; Child; Humans; Melatonin; Quality of Life; Sleep; Sleep Initia | 2022 |
Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson's disease and sleep disorders: a randomized, double-blind trial.
Topics: Clonazepam; Double-Blind Method; Humans; Iran; Melatonin; Parkinson Disease; Sleep Wake Disorders; T | 2022 |
Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders.
Topics: Autism Spectrum Disorder; Child; Exercise; Humans; Melatonin; Randomized Controlled Trials as Topic; | 2022 |
Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.
Topics: Child; Drug-Related Side Effects and Adverse Reactions; Humans; Melatonin; Meta-Analysis as Topic; N | 2022 |
Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.
Topics: Child; Drug-Related Side Effects and Adverse Reactions; Humans; Melatonin; Meta-Analysis as Topic; N | 2022 |
Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.
Topics: Child; Drug-Related Side Effects and Adverse Reactions; Humans; Melatonin; Meta-Analysis as Topic; N | 2022 |
Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.
Topics: Child; Drug-Related Side Effects and Adverse Reactions; Humans; Melatonin; Meta-Analysis as Topic; N | 2022 |
The effect of treatment with melatonin on primary school aged children with difficulty in initiation and maintenance of sleep.
Topics: Child; Double-Blind Method; Humans; Melatonin; Schools; Sleep; Sleep Initiation and Maintenance Diso | 2022 |
The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study.
Topics: Abdominal Pain; Double-Blind Method; Humans; Iran; Irritable Bowel Syndrome; Melatonin; Quality of L | 2023 |
Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Antioxidants; Child; Dietary Supplements; Fema | 2020 |
[Clinical efficacy of neurometabolic therapy of dissomical disorders in asthenic syndrome].
Topics: Administration, Oral; Antioxidants; Asthenia; Drug Combinations; Flavin Mononucleotide; Humans; Inos | 2019 |
Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP): a study protocol.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Central Nervous System Depressants | 2020 |
Melatonin effects on EEG activity during non-rapid eye movement sleep in mild-to-moderate Alzheimer´s disease: a pilot study.
Topics: Aged; Alzheimer Disease; Brain Waves; Central Nervous System Depressants; Cross-Over Studies; Electr | 2021 |
Melatonin Therapy Improves Cardiac Autonomic Modulation in Pinealectomized Patients.
Topics: Adolescent; Adult; Autonomic Nervous System; Central Nervous System Depressants; Child; Female; Foll | 2020 |
Melatonin for Treatment-Seeking Alcohol Use Disorder patients with sleeping problems: A randomized clinical pilot trial.
Topics: Adult; Aged; Alcoholism; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Me | 2020 |
Prolonged-release melatonin in Parkinson's disease patients with a poor sleep quality: A randomized trial.
Topics: Adult; Central Nervous System Depressants; Circadian Rhythm; Delayed-Action Preparations; Double-Bli | 2020 |
Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson's disease.
Topics: Adult; Aged; ARNTL Transcription Factors; Cross-Over Studies; Double-Blind Method; Female; Gene Expr | 2020 |
Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders.
Topics: Adolescent; Autism Spectrum Disorder; Child; Female; Humans; Japan; Male; Melatonin; Neurodevelopmen | 2020 |
Efficacy of Melatonin for Sleep Disturbance in Children with Persistent Post-Concussion Symptoms: Secondary Analysis of a Randomized Controlled Trial.
Topics: Actigraphy; Adolescent; Antioxidants; Child; Double-Blind Method; Female; Humans; Male; Melatonin; P | 2021 |
Melatonin Treatment and Adequate Sleep Hygiene Interventions in Children with Autism Spectrum Disorder: A Randomized Controlled Trial.
Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep; Sleep Hygiene; Sleep Wake Disorders | 2022 |
Efficacy of melatonin for sleep disturbance following traumatic brain injury: a randomised controlled trial.
Topics: Actigraphy; Adult; Anxiety; Australia; Brain Injuries, Traumatic; Cross-Over Studies; Double-Blind M | 2018 |
Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea-results from a double-blind cross-over intervention pilot study.
Topics: Adult; Antioxidants; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Dysmenorr | 2018 |
Study protocol for a randomised controlled trial examining the association between physical activity and sleep quality in children with autism spectrum disorder based on the melatonin-mediated mechanism model.
Topics: Autism Spectrum Disorder; Child; Exercise; Humans; Melatonin; Randomized Controlled Trials as Topic; | 2018 |
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Topics: Actigraphy; Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Male; Melatonin; Middle Ag | 2018 |
Randomized Controlled Trial of Melatonin for Sleep Disturbance in Dravet Syndrome: The DREAMS Study.
Topics: Actigraphy; Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Cross-Over Studies; Do | 2018 |
Early versus late wake therapy improves mood more in antepartum versus postpartum depression by differentially altering melatonin-sleep timing disturbances.
Topics: Adult; Affect; Circadian Rhythm; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; | 2019 |
Phase I dose-finding study for melatonin in pediatric oncology patients with relapsed solid tumors.
Topics: Adolescent; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Child; Child, Pr | 2019 |
Melatonin, temazepam and placebo in hospitalised older patients with sleeping problems (MATCH): a study protocol of randomised controlled trial.
Topics: Aged; Arousal; Delayed-Action Preparations; Geriatrics; Hospitalization; Humans; Hypnotics and Sedat | 2019 |
Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder.
Topics: Adult; Australia; Biological Variation, Population; Case-Control Studies; Central Nervous System Dep | 2019 |
A Jerte valley cherry product provides beneficial effects on sleep quality. Influence on aging.
Topics: Actigraphy; Adult; Aged; Aged, 80 and over; Aging; Body Mass Index; Cross-Over Studies; Dietary Supp | 2013 |
[An open-label non-comparative study of the efficacy and safety of melaxen in treatment of sleep disorders in alcohol dependent patients during the period of abstinence].
Topics: Administration, Oral; Adult; Alcoholism; Antioxidants; Cognitive Behavioral Therapy; Dose-Response R | 2013 |
Randomized controlled trial of pharmacological replacement of melatonin for sleep disruption in individuals with tetraplegia.
Topics: Antioxidants; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Mela | 2014 |
A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: effects on subjective and objective sleep.
Topics: Actigraphy; Adolescent; Adult; Double-Blind Method; Female; Humans; Light; Male; Melatonin; Norway; | 2014 |
Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antidepressive Agents; Anxiety; Breast Neoplasms; Central Nervous System Depressants; D | 2014 |
Sleep disruption in tetraplegia: a randomised, double-blind, placebo-controlled crossover trial of 3 mg melatonin.
Topics: Adult; Affect; Aged; Antioxidants; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Me | 2014 |
What are the four phases of clinical research trials?
Topics: Biomedical Research; Central Nervous System Depressants; Child; Clinical Trials as Topic; Humans; Me | 2014 |
[Treatment of sleep disorders in patients with mild cranial-brain injury in the early rehabilitation period].
Topics: Adult; Brain Injuries; Female; Humans; Male; Melatonin; Middle Aged; Sleep Wake Disorders; Treatment | 2014 |
Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness.
Topics: Adult; Circadian Rhythm; Female; Humans; Lighting; Male; Melatonin; Reading; Sleep; Sleep Wake Disor | 2015 |
Impact of Melatonin on Sleep and Pain After Total Knee Arthroplasty Under Regional Anesthesia With Sedation: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.
Topics: Aged; Anesthesia, Conduction; Arthroplasty, Replacement, Knee; Central Nervous System Depressants; D | 2015 |
Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's Disease Patients with Sleep Disturbances.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Caregivers; Donepezil; Female; Hum | 2015 |
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud | 2016 |
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud | 2016 |
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud | 2016 |
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial.
Topics: Adolescent; Biomarkers; Central Nervous System Depressants; Child; Child, Preschool; Cross-Over Stud | 2016 |
Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial.
Topics: Administration, Oral; Clinical Protocols; Cost-Benefit Analysis; Critical Care; Delirium; Double-Bli | 2017 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Topics: Activities of Daily Living; Affect; Aged, 80 and over; Circadian Rhythm; Cognition; Combined Modalit | 2008 |
Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease.
Topics: Aged; Central Nervous System Depressants; Double-Blind Method; Female; Humans; Lung Diseases, Obstru | 2008 |
Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Central Nervous System Depressants; Circadian Rhythm; Double-Blind Method; | 2009 |
Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Aged, 80 and over; Anxiety; Behavioral Symptoms; Cross-Over Studies; Depression; Double-Blind | 2009 |
The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome.
Topics: Adolescent; Autistic Disorder; Central Nervous System Depressants; Child; Child, Preschool; Cross-Ov | 2009 |
A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood.
Topics: Adult; Antidepressive Agents; Central Nervous System Depressants; Delayed-Action Preparations; Depre | 2010 |
Melatonin and sleep-related problems in children with intractable epilepsy.
Topics: Adolescent; Bruxism; Child; Child, Preschool; Epilepsy; Female; Humans; Hypnotics and Sedatives; Mal | 2010 |
Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: a randomised controlled crossover trial.
Topics: Adolescent; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive; Child | 2011 |
A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial.
Topics: Actigraphy; Adult; Dietary Supplements; Double-Blind Method; Fatty Acids, Unsaturated; Female; Human | 2010 |
Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy.
Topics: Child; Child, Preschool; Epilepsy; Humans; Melatonin; Placebos; Sleep Wake Disorders; Treatment Outc | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women.
Topics: Adrenocorticotropic Hormone; Aged; Double-Blind Method; Estrogen Replacement Therapy; Female; Gonada | 2011 |
Prolonged-release melatonin for children with neurodevelopmental disorders.
Topics: Adolescent; Antioxidants; Child; Child, Preschool; Developmental Disabilities; Drug Delivery Systems | 2011 |
Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.
Topics: Central Nervous System Depressants; Embryo Transfer; Embryo, Mammalian; Female; Fertilization in Vit | 2011 |
Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality.
Topics: Actigraphy; Adolescent; Adult; Beverages; Cross-Over Studies; Dietary Supplements; Double-Blind Meth | 2012 |
Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes.
Topics: Autistic Disorder; Central Nervous System Depressants; Child; Child, Preschool; Female; Humans; Male | 2012 |
A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Cerebral Infarction; Depression; | 2012 |
The use of MElatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS).
Topics: Adolescent; Behavior Therapy; Central Nervous System Depressants; Child; Child, Preschool; Developme | 2012 |
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.
Topics: Adolescent; Central Nervous System Depressants; Central Nervous System Diseases; Child; Child Behavi | 2012 |
[Sleep disorders in Parkinson's disease without dementia: a comparative randomized controlled study of melatonin and clonazepam].
Topics: Aged; Antioxidants; Clonazepam; Drug Therapy, Combination; Female; Humans; Male; Melatonin; Middle A | 2012 |
Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia.
Topics: Aged; Aged, 80 and over; Cross-Over Studies; Delayed-Action Preparations; Dementia; Double-Blind Met | 2002 |
Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder.
Topics: Adolescent; Adolescent Behavior; Asperger Syndrome; Child; Child Behavior; Female; Humans; Male; Mel | 2003 |
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antioxidants; Circadian Rhythm; Delayed-Action Preparations; Double-Blind M | 2003 |
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antioxidants; Circadian Rhythm; Delayed-Action Preparations; Double-Blind M | 2003 |
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antioxidants; Circadian Rhythm; Delayed-Action Preparations; Double-Blind M | 2003 |
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antioxidants; Circadian Rhythm; Delayed-Action Preparations; Double-Blind M | 2003 |
Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.
Topics: Adult; Aged; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Melatonin; Middle Aged; Na | 2004 |
The value of melatonin for sleep disorders occurring post-head injury: a pilot RCT.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antioxidants; Cognition; Cranioc | 2004 |
Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Asthma; Disorders of Excessive Somnol | 2004 |
Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin.
Topics: Administration, Oral; Adolescent; Antioxidants; Case-Control Studies; Child; Child, Preschool; Circa | 2005 |
Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex.
Topics: Administration, Oral; Adult; Antioxidants; Child; Child, Preschool; Cross-Over Studies; Dose-Respons | 2005 |
Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Epilepsies | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Topics: Abdominal Pain; Adult; Defecation; Double-Blind Method; Female; Humans; Irritable Bowel Syndrome; Ma | 2005 |
Melatonin for sleep disturbances in Parkinson's disease.
Topics: Adult; Aged; Anticonvulsants; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Met | 2005 |
Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study.
Topics: Adult; Aged; Anxiety; Depressive Disorder; Double-Blind Method; Female; Gastrointestinal Agents; Hum | 2005 |
Melatonin treatment in Smith Magenis syndrome.
Topics: Antioxidants; Chronobiology Disorders; Double-Blind Method; Humans; Intellectual Disability; Melaton | 2005 |
Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Fem | 2006 |
The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Ag | 2006 |
Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study.
Topics: Adult; Aged; Analysis of Variance; Antioxidants; Double-Blind Method; Female; Humans; Male; Melatoni | 2007 |
Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; Circad | 2007 |
Melatonin pharmacokinetics in premenopausal and postmenopausal healthy female volunteers.
Topics: Administration, Oral; Adult; Age Factors; Analysis of Variance; Area Under Curve; Body Mass Index; C | 2008 |
Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial.
Topics: Administration, Oral; Aged; Area Under Curve; Central Nervous System Depressants; Critical Illness; | 2008 |
Potential of melatonin replacement therapy in older patients with sleep disorders.
Topics: Aged; Delayed-Action Preparations; Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders | 1995 |
Disruption of the diurnal rhythm of plasma melatonin in cirrhosis.
Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Liver Cirrhosis; Male; Melatonin; Middle Aged; | 1995 |
The treatment of sleep disorders with melatonin.
Topics: Adolescent; Blindness; Child; Child, Preschool; Chronic Disease; Circadian Rhythm; Disabled Persons; | 1994 |
Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arousal; Circadian Rhythm; Dementia, Multi-Infarct; Fema | 1994 |
Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings.
Topics: Adult; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Melatonin; Memory; Mental Proces | 1993 |
Melatonin appears ineffective in children with intellectual deficits and fragmented sleep: six "N of 1" trials.
Topics: Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Intellectual Disability; M | 1996 |
Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Blindness; Body Temperature; Child; Child, Pre | 1997 |
Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder.
Topics: Affect; Bipolar Disorder; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Drug | 1997 |
Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations.
Topics: Humans; Male; Melatonin; Middle Aged; Motor Activity; Polysomnography; Sleep Stages; Sleep Wake Diso | 1997 |
Effect of melatonin on tinnitus.
Topics: Adult; Aged; Aged, 80 and over; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Melat | 1998 |
Correlation between concentrations of melatonin in saliva and serum in patients with delayed sleep phase syndrome.
Topics: Circadian Rhythm; Humans; Melatonin; Radioimmunoassay; Regression Analysis; Saliva; Sleep Wake Disor | 1998 |
Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome (DSPS).
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Patient Selection; Sleep; Sleep Wake Disor | 1998 |
Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment.
Topics: Anticonvulsants; Antioxidants; Child; Cross-Over Studies; Double-Blind Method; Female; Humans; Melat | 1998 |
Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations.
Topics: Adolescent; Biological Clocks; Double-Blind Method; Female; Headache; Humans; Male; Melatonin; Middl | 1998 |
Can melatonin improve adaptation to night shift?
Topics: Adaptation, Physiological; Adult; Affect; Biological Clocks; Circadian Rhythm; Cross-Over Studies; D | 1998 |
Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset.
Topics: Adult; Antioxidants; Body Temperature; Cross-Over Studies; Double-Blind Method; Female; Humans; Ligh | 1998 |
Melatonin for the treatment of sleep disturbances in major depressive disorder.
Topics: Adult; Aged; Ambulatory Care; Analysis of Variance; Delayed-Action Preparations; Depressive Disorder | 1998 |
Use of melatonin to treat sleep disorders in tuberous sclerosis.
Topics: Adolescent; Adult; Child, Preschool; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Bl | 1999 |
Melatonin ineffective in neuronal ceroid lipofuscinosis patients with fragmented or normal motor activity rhythms recorded by wrist actigraphy.
Topics: Adolescent; Adult; Antioxidants; Child; Circadian Rhythm; Dose-Response Relationship, Drug; Electrop | 1999 |
Light mask 500 lux treatment for delayed sleep phase syndrome.
Topics: Adult; Affect; Analysis of Variance; Biomarkers; Body Temperature; Circadian Rhythm; Female; Humans; | 1999 |
Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial.
Topics: Aerospace Medicine; Circadian Rhythm; Double-Blind Method; Health Status; Humans; Melatonin; Placebo | 1999 |
[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders].
Topics: Adolescent; Adult; Affective Symptoms; Child; Child, Preschool; Circadian Rhythm; Developmental Disa | 1999 |
The effect of melatonin in patients with fibromyalgia: a pilot study.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Fatigue Syndrome, Chronic; Female; Fibromyalgia; | 2000 |
Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders.
Topics: Adolescent; Adult; Child; Child, Preschool; Cross-Over Studies; Delayed-Action Preparations; Develop | 2000 |
Effects of exogenous melatonin on pituitary hormones in humans.
Topics: Administration, Oral; Adolescent; Adult; Antioxidants; Circadian Rhythm; Double-Blind Method; Female | 2001 |
Melatonin for treatment of sleep disorders in children with developmental disabilities.
Topics: Antioxidants; Child; Child, Preschool; Developmental Disabilities; Double-Blind Method; Humans; Infa | 2001 |
Effects of six months melatonin treatment on sleep quality and serum concentrations of estradiol, cortisol, dehydroepiandrosterone sulfate, and somatomedin C in elderly women.
Topics: Aged; Aged, 80 and over; Antioxidants; Blood Cell Count; Dehydroepiandrosterone Sulfate; Estradiol; | 2002 |
Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study.
Topics: Adolescent; Child; Child, Preschool; Developmental Disabilities; Dose-Response Relationship, Drug; E | 2002 |
Negative effects of melatonin on depression.
Topics: Adult; Anger; Anxiety; Body Temperature; Body Weight; Calcium; Clinical Trials as Topic; Depression; | 1976 |
Delayed sleep phase syndrome response to melatonin.
Topics: Administration, Oral; Adolescent; Adult; Biological Clocks; Double-Blind Method; Drug Administration | 1991 |
Melatonin administration to blind people: phase advances and entrainment.
Topics: Adult; Blindness; Circadian Rhythm; Double-Blind Method; Humans; Hydrocortisone; Male; Melatonin; Sl | 1991 |
Melatonin secretion related to side-effects of beta-blockers from the central nervous system.
Topics: Adult; Atenolol; Circadian Rhythm; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertensi | 1988 |
339 other studies available for melatonin and Sleep Wake Disorders
| Article | Year |
|---|---|
[The effect of long-term beta-blockers on melatonin secretion, sleep quality, and vascular brain damage].
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders; Suprachiasmatic Nucleus | 2021 |
Effect of melatonin and melatonin agonists on postoperative sleep quality in adult patients: a protocol for systematic review and meta-analysis with trial sequential analysis.
Topics: Adult; Humans; Melatonin; Meta-Analysis as Topic; Sleep; Sleep Wake Disorders; Systematic Reviews as | 2021 |
Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats.
Topics: Animals; Circadian Rhythm; Dietary Supplements; Ischemia; Male; Melatonin; Rats; Rats, Sprague-Dawle | 2021 |
Dynamic white lighting to aid sleep and vision for persons living with dementia using off-the-shelf LED strips.
Topics: Aged; Alzheimer Disease; Circadian Clocks; Humans; Light; Lighting; Melatonin; Phototherapy; Sleep W | 2021 |
[Sleep disturbance associated with Smith-Magenis syndrome].
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Mice; Sleep; Sleep Wake Disorders; Smith-Magenis Syndr | 2021 |
Prednisolone induces sleep disorders via inhibition of melatonin secretion by the circadian rhythm in zebrafish.
Topics: Animals; Anti-Inflammatory Agents; Circadian Rhythm; Melatonin; Models, Animal; Prednisolone; Sleep | 2022 |
Effects of exercise on sleep, melatonin level, and behavioral functioning in children with autism.
Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Exercise; Humans; Melatonin; Sleep; Sleep Wake D | 2022 |
Modeling the relationship between shift work and cardiometabolic risk through circadian disruption, sleep and stress pathways.
Topics: Cardiovascular Diseases; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Hydrocortisone; | 2022 |
Women with polycystic ovary syndrome (PCOS) have reduced melatonin concentrations in their follicles and have mild sleep disturbances.
Topics: Female; Fertilization in Vitro; Follicular Fluid; Humans; Melatonin; Polycystic Ovary Syndrome; Preg | 2022 |
Characterizing sleep disorders in an autism-specific collection of electronic health records.
Topics: Adolescent; Adult; Autism Spectrum Disorder; Autistic Disorder; Child; Electronic Health Records; Hu | 2022 |
[Pre-pandemic melatonin treatment for sleep disorders and COVID-19 infection. A retrospective cross-sectional study].
Topics: Adult; Aged; Aged, 80 and over; COVID-19; Cross-Sectional Studies; Humans; Melatonin; Middle Aged; P | 2022 |
Melatonin pretreatment prevents propofol-induced sleep disturbance by modulating circadian rhythm in rats.
Topics: Animals; Circadian Rhythm; Glycogen Synthase Kinase 3 beta; Humans; Melatonin; Propofol; Rats; Sleep | 2022 |
Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson's disease: a preliminary evidence.
Topics: Disabled Persons; Humans; Melatonin; Motor Disorders; Parkinson Disease; Pilot Projects; Quality of | 2022 |
Melatonin usage in children and young adults, a registry-based cohort study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child; Cohort S | 2022 |
Sleep Problems and 6-Sulfatoxymelatonin as Possible Predictors of Symptom Severity, Adaptive and Maladaptive Behavior in Children with Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2022 |
Investigating the genetic pathways of insomnia in Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Child; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Initiation and Ma | 2022 |
Eyes wide open: sleep disturbance, not melatonin, is the real issue to address for suicide risk.
Topics: Humans; Melatonin; Sleep; Sleep Wake Disorders; Suicide Prevention | 2022 |
Diurnal variation of clock genes expression and other sleep-wake rhythm biomarkers among acute ischemic stroke patients.
Topics: Biomarkers; Circadian Rhythm; Humans; Hydrocortisone; Ischemic Stroke; Male; Melatonin; Middle Aged; | 2022 |
Ultra-low-dose early night ramelteon administration for the treatment of delayed sleep-wake phase disorder: case reports with a pharmacological review.
Topics: Circadian Rhythm; Humans; Indenes; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake D | 2022 |
The night before night shift: Chronotype impacts total sleep and rapid eye movement sleep during a strategically delayed sleep.
Topics: Adult; Chronotype; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep Wake Disorders; S | 2023 |
Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study.
Topics: Animals; Autism Spectrum Disorder; beta-Glucans; Glucans; Humans; Melatonin; Pilot Projects; Prospec | 2022 |
Use of melatonin: a single-centre audit.
Topics: Adolescent; Autism Spectrum Disorder; Child; Humans; Melatonin; Neurodevelopmental Disorders; Sleep | 2022 |
The effects of morning/afternoon surgeries on the early postoperative sleep quality of patients undergoing general anesthesia.
Topics: Anesthesia, General; Blood Glucose; Humans; Hydrocortisone; Melatonin; Postoperative Period; Sleep Q | 2022 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
The circadian variation of sleep and alertness of postmenopausal women.
Topics: Aged; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep; Sleep Wak | 2023 |
Sleep disturbances and the association with attenuated psychotic symptoms in individuals at ultra high-risk of psychosis.
Topics: Adolescent; Adult; Humans; Melatonin; Psychiatric Status Rating Scales; Psychotic Disorders; Risk Fa | 2023 |
3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder.
Topics: Caffeine; Drug Liberation; Humans; Melatonin; Printing, Three-Dimensional; Sleep Wake Disorders; Tab | 2023 |
Multiplatform-Integrated Identification of Melatonin Targets for a Triad of Psychosocial-Sleep/Circadian-Cardiometabolic Disorders.
Topics: Animals; Circadian Rhythm; Melatonin; Metabolic Syndrome; Molecular Targeted Therapy; Receptors, Mel | 2023 |
Melatonin Treatment of Circadian Rhythm Sleep-Wake Disorder in Obese Children Affects the Brain-Derived Neurotrophic Factor Level.
Topics: Brain-Derived Neurotrophic Factor; Child; Circadian Rhythm; Humans; Melatonin; Pediatric Obesity; Sl | 2023 |
Continuous positive airway pressure as an accurate marker for non-24-hour sleep-wake rhythm disorder.
Topics: Autism Spectrum Disorder; Circadian Rhythm; Continuous Positive Airway Pressure; Humans; Male; Melat | 2023 |
Structural properties and binding mechanism of DNA aptamers sensing saliva melatonin for diagnosis and monitoring of circadian clock and sleep disorders.
Topics: Aptamers, Nucleotide; Circadian Clocks; Circadian Rhythm; Humans; Melatonin; Saliva; Sleep Disorders | 2023 |
Examination of correlations between vitamin D and melatonin levels with sleep among women aged 18-49 years.
Topics: Cholecalciferol; Cross-Sectional Studies; Female; Humans; Melatonin; Sleep; Sleep Wake Disorders; Vi | 2023 |
An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor.
Topics: Actigraphy; Circadian Rhythm; Cognitive Dysfunction; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2023 |
What a difference a year makes: Objective rest/activity patterns, circadian phase markers, and sleep quality before and during the COVID-19 pandemic.
Topics: Circadian Rhythm; COVID-19; Female; Humans; Longitudinal Studies; Male; Melatonin; Pandemics; Sleep | 2023 |
Melatonin ameliorates sleep-wake disturbances and autism-like behaviors in the Ctnnd2 knock out mouse model of autism spectrum disorders.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Melatonin; Mice; Mice, Knockout; Sleep; Sleep | 2023 |
Factors associated with melatonin use in child sleep disturbance: A survey of Australian parents.
Topics: Adolescent; Australia; Child; Female; Humans; Male; Melatonin; Parents; Sleep; Sleep Wake Disorders | 2023 |
Melatonin effects on sleep quality of COVID-19 patients: a protocol for systematic review and meta-analysis of randomised controlled trials with trial sequential analysis.
Topics: COVID-19; Humans; Melatonin; Meta-Analysis as Topic; Sleep Quality; Sleep Wake Disorders; Systematic | 2023 |
Sleep disturbances in subjects with autism spectrum disorder: A parental perspective.
Topics: Autism Spectrum Disorder; Child; Humans; Melatonin; Parents; Quality of Life; Retrospective Studies; | 2023 |
Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort.
Topics: Autism Spectrum Disorder; Child; Female; Humans; Male; Melatonin; Movement Disorders; Parasomnias; R | 2023 |
Sleep, melatonin, and cardiovascular disease.
Topics: Cardiovascular Diseases; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2023 |
Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event.
Topics: Adult; Biomarkers; Cognitive Dysfunction; Disease Progression; Enzyme-Linked Immunosorbent Assay; Fe | 2020 |
Prevalence of sleep disorders in early-treated phenylketonuric children and adolescents. Correlation with dopamine and serotonin status.
Topics: Adolescent; Biomarkers; Child; Dopamine; Female; Humans; Male; Melatonin; Phenylketonurias; Prevalen | 2019 |
Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm.
Topics: Actigraphy; Adult; Brain Injuries; Brain Injuries, Traumatic; Circadian Clocks; Circadian Rhythm; Fe | 2020 |
Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder.
Topics: Adolescent; Autism Spectrum Disorder; Case-Control Studies; Child; Child, Preschool; Humans; Melaton | 2019 |
Sleep Problems and Melatonin Use in School-aged Children.
Topics: Child; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2020 |
Sleep Parameters and Overnight Urinary Melatonin Production in Children With Persistent Post-concussion Symptoms.
Topics: Actigraphy; Adolescent; Child; Female; Humans; Male; Melatonin; Post-Concussion Syndrome; Prospectiv | 2020 |
Self-reported sleep disturbance in Crohn's disease is not confirmed by objective sleep measures.
Topics: Actigraphy; Adolescent; Adult; Case-Control Studies; Crohn Disease; Female; Healthy Volunteers; Huma | 2020 |
Evaluating a nurse-led sleep support intervention to reduce melatonin prescribing in children and young people.
Topics: Cognitive Behavioral Therapy; Deprescriptions; Female; Humans; Male; Melatonin; Practice Patterns, N | 2020 |
Sleep parameters assessed by actigraphy in Fabry's disease patients: a proof-of-concept.
Topics: Actigraphy; Adult; Case-Control Studies; Cross-Sectional Studies; Fabry Disease; Female; Humans; Mal | 2020 |
Parent survey of sleep problems among children with CHARGE syndrome.
Topics: Adolescent; Anxiety; Central Nervous System Depressants; CHARGE Syndrome; Child; Child, Preschool; C | 2020 |
Sleep and circadian instability in delayed sleep-wake phase disorder.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders | 2020 |
Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study.
Topics: Actigraphy; Aged; Case-Control Studies; Circadian Rhythm; Depression; Female; Humans; Male; Melatoni | 2020 |
Delirium and sleep disturbances in COVID-19: a possible role for melatonin in hospitalized patients?
Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Delirium; Humans; Melatonin; Pandemics; Pneumonia | 2020 |
Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads.
Topics: Alginates; Drug Carriers; Drug Compounding; Drug Liberation; Hydrogels; Hydrogen-Ion Concentration; | 2020 |
Characterization of sleep habits and medication outcomes for sleep disturbance in children and adults with Angelman syndrome.
Topics: Adolescent; Adult; Angelman Syndrome; Child; Child, Preschool; Clonidine; Female; Humans; Male; Mela | 2020 |
Sleep duration and timing in obsessive-compulsive disorder (OCD): evidence for circadian phase delay.
Topics: Circadian Rhythm; Humans; Melatonin; Obsessive-Compulsive Disorder; Sleep; Sleep Disorders, Circadia | 2020 |
Circadian tau differences and rhythm associations in delayed sleep-wake phase disorder and sighted non-24-hour sleep-wake rhythm disorder.
Topics: Adolescent; Adult; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sl | 2021 |
Pediatric use of prescribed melatonin in Sweden 2006-2017: a register based study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Female; Humans; Male; Melatonin; P | 2021 |
Screening of sleep assisting drug candidates with a Drosophila model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Circadian Rhythm; Disease Models, Animal; Drosoph | 2020 |
The impact of structured sleep schedules prior to an in-laboratory study: Individual differences in sleep and circadian timing.
Topics: Adult; Circadian Rhythm; Female; Humans; Individuality; Light; Male; Melatonin; Middle Aged; Saliva; | 2020 |
Yokukansankachimpihange, a traditional Japanese (Kampo) medicine, enhances the adaptation to circadian rhythm disruption by increasing endogenous melatonin levels.
Topics: Adaptation, Biological; Animals; Circadian Rhythm; Drugs, Chinese Herbal; Male; Medicine, Kampo; Mel | 2020 |
Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice.
Topics: Activity Cycles; Age Factors; Anesthetics, Inhalation; Animals; Circadian Rhythm; Electroencephalogr | 2021 |
Melanopsin Cell Dysfunction is Involved in Sleep Disruption in Parkinson's Disease.
Topics: Actigraphy; Aged; Chronobiology Disorders; Female; Humans; Male; Melatonin; Middle Aged; Parkinson D | 2020 |
Sleep Problems and Melatonin Prescription After Concussion Among Youth Athletes.
Topics: Adolescent; Athletes; Athletic Injuries; Brain Concussion; Child; Female; Humans; Male; Melatonin; P | 2021 |
Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.
Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sle | 2021 |
Melatonin dispensing among New Zealand children aged 0-18 years with autism: a nationwide cross-sectional study.
Topics: Adolescent; Autism Spectrum Disorder; Autistic Disorder; Child; Child, Preschool; Cross-Sectional St | 2021 |
Advances in the pharmacological management of non-24-h sleep-wake disorder.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders | 2021 |
Autism Spectrum Disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin.
Topics: Autism Spectrum Disorder; Circadian Rhythm; COVID-19; Disease Susceptibility; Genetic Variation; Hum | 2021 |
Impact of COVID-19 on serum melatonin levels and sleep parameters in children
Topics: Adolescent; Child; Cohort Studies; COVID-19; Cross-Sectional Studies; Female; Humans; Male; Melatoni | 2021 |
Assessing Sleep Architecture With Polysomnography During Posttraumatic Amnesia After Traumatic Brain Injury: A Pilot Study.
Topics: Adult; Aged; Amnesia; Brain Injuries, Traumatic; Feasibility Studies; Female; Humans; Male; Melatoni | 2021 |
Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer's disease.
Topics: Actigraphy; Affect; Aged; Aged, 80 and over; Alzheimer Disease; Behavior; Circadian Rhythm; Cognitio | 2021 |
Treatment of a patient with a circadian sleep-wake disorder using a combination of melatonin and metoprolol.
Topics: Circadian Rhythm; Humans; Melatonin; Metoprolol; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wak | 2021 |
Behaviorally and environmentally induced non-24-hour sleep-wake rhythm disorder in sighted patients.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders | 2022 |
Pharmacology Focus: The Use of Melatonin For Pediatric Sleep Disorders.
Topics: Child; Humans; Melatonin; Sleep Wake Disorders | 2021 |
Melatonin and circadian rhythms in autism: Case report.
Topics: Autistic Disorder; Behavior; Child; Circadian Rhythm; Humans; Male; Melatonin; Rest; Sleep; Sleep Wa | 2017 |
Evening light exposure to computer screens disrupts human sleep, biological rhythms, and attention abilities.
Topics: Adult; Attention; Biomarkers; Body Temperature Regulation; Circadian Rhythm; Computers; Female; Huma | 2017 |
Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders.
Topics: Actigraphy; Adolescent; Adult; Anxiety Disorders; Body Temperature; Circadian Rhythm; Female; Humans | 2017 |
Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Circadian Rhythm; Depression; Fatigue; Female; | 2017 |
Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis.
Topics: Actigraphy; Adult; Bipolar Disorder; Case-Control Studies; Circadian Rhythm; Depressive Disorder, Ma | 2018 |
Treating delayed sleep-wake phase disorder in young adults.
Topics: Combined Modality Therapy; Humans; Male; Melatonin; Phototherapy; Sleep Wake Disorders; Young Adult | 2017 |
Analysis of Different Melatonin Secretion Patterns in Children With Sleep Disorders: Melatonin Secretion Patterns in Children.
Topics: Actigraphy; Adolescent; Child; Child, Preschool; Female; Humans; Male; Melatonin; Polysomnography; S | 2017 |
The effect of agomelatine and melatonin on sleep-related eating: a case report.
Topics: Acetamides; Central Nervous System Depressants; Depressive Disorder, Major; Female; Humans; Melatoni | 2017 |
Sleep Disturbance Following Concussion Is a Risk Factor for a Prolonged Recovery.
Topics: Adolescent; Brain Concussion; Central Nervous System Depressants; Female; Humans; Male; Melatonin; R | 2017 |
Nocturnal serum melatonin levels in sulfur mustard exposed patients with sleep disorders.
Topics: Case-Control Studies; Chemical Warfare Agents; Cross-Sectional Studies; Humans; Iran; Lung Diseases; | 2017 |
Clinical Considerations Derived From the Administration of Melatonin to Children With Sleep Disorders.
Topics: Actigraphy; Adolescent; Child; Circadian Rhythm; Female; Humans; Male; Melatonin; Outcome Assessment | 2018 |
Heritability of the melatonin synthesis variability in autism spectrum disorders.
Topics: Adolescent; Adult; Arylalkylamine N-Acetyltransferase; Autism Spectrum Disorder; Child; Endophenotyp | 2017 |
[Effect of Reading a Book on a Tablet Computer on Cerebral Blood Flow in the Prefrontal Cortex].
Topics: Adult; Books; Cerebrovascular Circulation; Computers, Handheld; Humans; Male; Melatonin; Prefrontal | 2018 |
Diagnostic and Treatment Challenges of Sighted Non-24-Hour Sleep-Wake Disorder.
Topics: Actigraphy; Adolescent; Adult; Diaries as Topic; Female; Humans; Male; Melatonin; Middle Aged; Photo | 2018 |
Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances.
Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Cross-Sectional Studies; Female; Humans; Leukemia; | 2018 |
Day/night melatonin content in cerebral palsy.
Topics: Adolescent; Cerebral Palsy; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Male; Melaton | 2018 |
Fabrication and Characterization of Electrospun Nanofibers for the Modified Release of the Chronobiotic Hormone Melatonin.
Topics: Administration, Oral; Cellulose; Central Nervous System Depressants; Delayed-Action Preparations; Dr | 2019 |
Advanced Circadian Timing and Sleep Fragmentation Differentially Impact on Memory Complaint Subtype in Subjective Cognitive Decline.
Topics: Aged; Chronobiology Disorders; Cognition Disorders; Female; Humans; Male; Melatonin; Memory Disorder | 2018 |
Habitual light exposure relative to circadian timing in delayed sleep-wake phase disorder.
Topics: Actigraphy; Adult; Aged; Circadian Rhythm; Female; Habits; Humans; Male; Melatonin; Middle Aged; Pho | 2018 |
[Thoughts about Light and Sleep].
Topics: Circadian Rhythm; Humans; Light; Melatonin; Sleep; Sleep Wake Disorders | 2019 |
Disruption of sleep, sleep-wake activity rhythm, and nocturnal melatonin production in breast cancer patients undergoing adjuvant chemotherapy: prospective cohort study.
Topics: Actigraphy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Breast Neoplasm | 2019 |
Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism.
Topics: Autism Spectrum Disorder; Autistic Disorder; Circadian Rhythm; Comorbidity; Databases, Genetic; Dopa | 2020 |
Variations in Genes Related to Sleep Patterns in Children With Autism Spectrum Disorder.
Topics: Adolescent; Autism Spectrum Disorder; Child; Child, Preschool; Circadian Rhythm; Comorbidity; Female | 2019 |
[Correlations of Melatonin and Glutathione Levels with Oxidative Stress Mechanism in Parkinson's Disease].
Topics: Case-Control Studies; Cognitive Dysfunction; Glutathione; Humans; Melatonin; Oxidative Stress; Parki | 2019 |
The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS).
Topics: Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Utilization; France; Guideline Adher | 2019 |
Regulation of Circadian Clock Genes on Sleep Disorders in Traumatic Brain Injury Patients.
Topics: Adolescent; Adult; ARNTL Transcription Factors; Brain Injuries; Circadian Clocks; CLOCK Proteins; Fe | 2019 |
A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study.
Topics: Adult; Aged; Female; Humans; Male; Melatonin; Middle Aged; Pilot Projects; Plant Preparations; Plant | 2019 |
Melatonin: helping to MEND impaired sleep.
Topics: Child; Humans; Melatonin; Sleep Wake Disorders | 2013 |
Poor sleep in PCOS; is melatonin the culprit?
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Case-Control Studies; Deoxyguanosine; Female; Hormon | 2013 |
A two-night comparison in the sleep laboratory as a tool to challenge the relationship between sleep initiation, cardiophysiological and thermoregulatory changes in women with difficulties initiating sleep and thermal discomfort.
Topics: Adult; Body Temperature; Body Temperature Regulation; Cross-Over Studies; Electrocardiography; Femal | 2013 |
Question 1: in a child with epilepsy, does melatonin affect the seizure threshold?
Topics: Child; Epilepsy; Humans; Melatonin; Sleep Wake Disorders | 2013 |
Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy.
Topics: Adult; Aged; Anesthesia, General; Breast Neoplasms; Fatigue; Female; Humans; Mastectomy, Segmental; | 2013 |
Associations of endogenous melatonin and sleep-related factors with behavioral problems in preschool Japanese children.
Topics: Child; Child Behavior Disorders; Child, Preschool; Cross-Sectional Studies; Female; Humans; Japan; M | 2013 |
Urinary 6-sulphatoxymelatonin levels and sleep disorders in children with migraine.
Topics: Chi-Square Distribution; Child; Child, Preschool; Circadian Rhythm; Disability Evaluation; Female; H | 2014 |
Sleep efficiency in patients with polycystic ovarian syndrome.
Topics: Female; Humans; Melatonin; Polycystic Ovary Syndrome; Sleep; Sleep Wake Disorders | 2013 |
Reply: sleep efficiency in patients with polycystic ovarian syndrome.
Topics: Female; Humans; Melatonin; Polycystic Ovary Syndrome; Sleep; Sleep Wake Disorders | 2013 |
Circadian misalignment and sleep disruption in mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Biomarkers; Circadian Rhythm; Cognitive Dysfunction; Female; Humans; Male; | 2014 |
Temperament determination for melatonin: a bridge from Iranian traditional to modern sleep medicine.
Topics: Central Nervous System Depressants; Cold Temperature; Humans; Iran; Medicine, Traditional; Melatonin | 2013 |
Treatment of pediatric restless legs syndrome.
Topics: Adolescent; Amines; Analgesics; Anticonvulsants; Antioxidants; Benzothiazoles; Child; Child, Prescho | 2014 |
Pathogenic role of melatonin in sleep disorders in menopausal women.
Topics: Case-Control Studies; Circadian Rhythm; Female; Humans; Melatonin; Middle Aged; Perimenopause; Postm | 2013 |
Melatonin alterations and brain acetylcholine lesions in sleep disorders in Cockayne syndrome.
Topics: Acetylcholine; Adolescent; Adult; Antioxidants; Brain; Case-Control Studies; Child; Child, Preschool | 2014 |
Effects of a group-based step aerobics training on sleep quality and melatonin levels in sleep-impaired postmenopausal women.
Topics: Exercise; Female; Heart Rate; Humans; Melatonin; Middle Aged; Postmenopause; Sleep; Sleep Wake Disor | 2014 |
Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Hypnotics and Sedatives; Indoles; Male; M | 2014 |
Avoid sleep difficulties associated with mobile devices.
Topics: Cell Phone; Humans; Lighting; Melatonin; Sleep Wake Disorders; United States | 2013 |
HIV Tat protein affects circadian rhythmicity by interfering with the circadian system.
Topics: Biomarkers; Blood Pressure; Circadian Rhythm; Female; Heart Rate; HIV Infections; Humans; Male; Mela | 2014 |
Influence of light at night on melatonin suppression in children.
Topics: Adult; Age Factors; Child; Circadian Rhythm; Female; Humans; Lens, Crystalline; Light; Lighting; Mal | 2014 |
Atopic dermatitis, melatonin, and sleep disturbance.
Topics: Actigraphy; Child; Child, Preschool; Comorbidity; Cross-Sectional Studies; Cytokines; Dermatitis, At | 2014 |
Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men.
Topics: Age Factors; Biomarkers; Down-Regulation; Humans; Iceland; Incidence; Male; Melatonin; Proportional | 2015 |
Sleep disorders and inflammatory disease activity: chicken or the egg?
Topics: Animals; C-Reactive Protein; Circadian Rhythm; Clinical Trials as Topic; Colitis, Ulcerative; Crohn | 2015 |
Melatonin, sleep, and prostate cancer in elderly men: study, hypothesis development, and icelandic options.
Topics: Humans; Male; Melatonin; Prostatic Neoplasms; Sleep; Sleep Wake Disorders | 2015 |
Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome.
Topics: Actigraphy; Case-Control Studies; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Hydroco | 2015 |
Forced entrainment by using light therapy, modafinil and melatonin in a sighted patient with non-24-hour sleep-wake disorder.
Topics: Actigraphy; Benzhydryl Compounds; Combined Modality Therapy; Female; Humans; Melatonin; Modafinil; P | 2015 |
Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study.
Topics: Analysis of Variance; Central Nervous System Depressants; Child; Child, Preschool; Dose-Response Rel | 2015 |
The use of melatonin in Swedish children and adolescents--a register-based study according to age, gender, and medication of ADHD.
Topics: Adolescent; Adolescent Behavior; Age Factors; Attention Deficit Disorder with Hyperactivity; Central | 2015 |
A preliminary study on the relationships between diurnal melatonin secretion profile and sleep variables in patients emergently admitted to the coronary care unit.
Topics: Actigraphy; Cardiovascular Diseases; Case-Control Studies; Coronary Care Units; Critical Care; Femal | 2015 |
Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects.
Topics: Adult; Autistic Disorder; Behavior Therapy; Caregivers; Child; Cost of Illness; Cost-Benefit Analysi | 2015 |
Response to the letter "Sleep characteristics of children with Williams syndrome in relation to saliva melatonin and cortisol".
Topics: Female; Humans; Hydrocortisone; Male; Melatonin; Sleep Wake Disorders; Williams Syndrome | 2015 |
Sleep characteristics of children with Williams syndrome in relation to saliva melatonin and cortisol.
Topics: Female; Humans; Hydrocortisone; Male; Melatonin; Sleep Wake Disorders; Williams Syndrome | 2015 |
Safety of melatonin.
Topics: Epilepsy; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2015 |
Association of Urinary 6-Sulfatoxymelatonin (aMT6s) Levels and Objective and Subjective Sleep Measures in Older Men: The MrOS Sleep Study.
Topics: Aged; Cross-Sectional Studies; Humans; Male; Melatonin; Self Report; Sleep Wake Disorders | 2015 |
Analyses of melatonin, cytokines, and sleep in chronic renal failure.
Topics: Adult; Aged; Circadian Rhythm; Cytokines; Female; Humans; Interleukin-6; Kidney Failure, Chronic; Ma | 2016 |
Effect of melatonin on sleep disorders in a monkey model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Central Nervous System Depressants; Disease Models, Animal; Levodopa; | 2015 |
Pineal hypoplasia, reduced melatonin and sleep disturbance in patients with PAX6 haploinsufficiency.
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Cross-Sectional Studies; Eye Prote | 2016 |
Melatonin for sleep problems in children with neurodevelopmental disorders.
Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child; Humans; Hypnotics an | 2015 |
[Troubling increase in consumption of the sleeping drug melatonin for children].
Topics: Adolescent; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive; Drug | 2013 |
Melatonin pretreatment prevents isoflurane-induced cognitive dysfunction by modulating sleep-wake rhythm in mice.
Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Isoflurane; Male; Melaton | 2016 |
Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity.
Topics: Adolescent; Adult; Circadian Rhythm; Female; Glucose; Humans; Insulin; Insulin Resistance; Male; Mel | 2015 |
Sleep-promoting medications in children: physician prescribing habits in Southwestern Ontario, Canada.
Topics: Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Cross-Section | 2016 |
[LIGHT POLLUTION AS THE HYGIENIC PROBLEM].
Topics: Depression; Environmental Exposure; Environmental Monitoring; Environmental Pollution; Humans; Light | 2015 |
Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Humans; Leu | 2016 |
Melatonin rhythms in renal transplant recipients with sleep-wake disturbances.
Topics: Adult; Aged; Circadian Rhythm; Female; Humans; Kidney Transplantation; Light; Male; Melatonin; Middl | 2016 |
Reply to letter: Exogenous melatonin for Parkinson's disease: 'Waking up' to the need for further trials.
Topics: Humans; Melatonin; Parkinson Disease; Sleep Wake Disorders; Wakefulness | 2016 |
Circadian Melatonin and Temperature Taus in Delayed Sleep-wake Phase Disorder and Non-24-hour Sleep-wake Rhythm Disorder Patients: An Ultradian Constant Routine Study.
Topics: Adult; Body Temperature; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Saliva; Sleep; Sl | 2016 |
Evidence of Pineal Gland Calcification on CBCT is Not Insignificant: What Else You Might Discover about Your Patient.
Topics: Brain Diseases; Calcinosis; Cone-Beam Computed Tomography; Humans; Incidental Findings; Melatonin; P | 2016 |
[Sleep Disturbances in the Elderly].
Topics: Aged; Aged, 80 and over; Aging; Cataract; Circadian Rhythm; Humans; Melatonin; Sleep Apnea Syndromes | 2016 |
The Use of Melatonin by Children: Parents' Perspectives.
Topics: Adolescent; Attitude to Health; Australia; Central Nervous System Depressants; Child; Child, Prescho | 2016 |
Can the circadian phase be estimated from self-reported sleep timing in patients with Delayed Sleep Wake Phase Disorder to guide timing of chronobiologic treatment?
Topics: Adult; Body Temperature; Circadian Rhythm; Female; Humans; Male; Melatonin; Self Report; Sleep; Slee | 2016 |
Sleep and melatonin secretion abnormalities in children and adolescents with fetal alcohol spectrum disorders.
Topics: Adolescent; Child; Female; Fetal Alcohol Spectrum Disorders; Humans; Male; Melatonin; Parasomnias; P | 2016 |
Sleep Complaints and the 24-h Melatonin Level in Individuals with Smith-Magenis Syndrome: Assessment for Effective Intervention.
Topics: Adult; Age Factors; Child; Child, Preschool; Circadian Rhythm; Eating; Female; Humans; Male; Melaton | 2016 |
Sleep-Wake Disorders.
Topics: Central Nervous System Depressants; Humans; Melatonin; Sleep Wake Disorders | 2016 |
Sleep and circadian rhythm disturbance in bipolar disorder.
Topics: Adult; Bipolar Disorder; Circadian Rhythm; Comorbidity; Female; Humans; Male; Melatonin; Middle Aged | 2017 |
Immediate and prolonged-release melatonin in children with neurodevelopmental disabilities. Author reply to Prof. Zisapel.
Topics: Child; Developmental Disabilities; Disabled Persons; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2017 |
The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.
Topics: Acute Coronary Syndrome; Anxiety; Circadian Rhythm; Clinical Protocols; Depression; Double-Blind Met | 2017 |
Clinical update: melatonin and sleep disorders.
Topics: Central Nervous System Depressants; Humans; Melatonin; Sleep Wake Disorders | 2008 |
Sleep disorders: causes, effects, and solutions.
Topics: Behavior Therapy; Chronobiology Disorders; Drug Interactions; Drug-Related Side Effects and Adverse | 2008 |
[Symptomatic treatment in patients with dementia: light, but not melatonin, is probably worthwhile].
Topics: Affect; Aged; Aged, 80 and over; Cognition; Dementia; Depression; Female; Humans; Male; Melatonin; P | 2008 |
A personal light-treatment device for improving sleep quality in the elderly: dynamics of nocturnal melatonin suppression at two exposure levels.
Topics: Aged; Aged, 80 and over; Humans; Lighting; Melatonin; Middle Aged; Patient Selection; Phototherapy; | 2009 |
Melatonin arrhythmia is corrected after liver transplantation.
Topics: Circadian Rhythm; Female; Follow-Up Studies; Hepatitis C, Chronic; Humans; Liver Failure; Liver Tran | 2009 |
Delayed onset of the diurnal melatonin rise in patients with Huntington's disease.
Topics: Chronobiology Disorders; Circadian Rhythm; Disease Progression; Down-Regulation; Female; Humans; Hun | 2009 |
Different melatonin rhythms and sleep-wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis.
Topics: Actigraphy; Aged; Circadian Rhythm; Female; Humans; Kidney Failure, Chronic; Male; Melatonin; Middle | 2010 |
The role of melatonin in sleep disturbances in end-stage Huntington's disease.
Topics: Humans; Huntington Disease; Melatonin; Sleep Wake Disorders; Time Factors | 2009 |
Schizophrenia as a possible dysfunction of the suprachiasmatic nucleus.
Topics: Continuous Positive Airway Pressure; Delusions; Humans; Light; Melatonin; Models, Biological; Models | 2010 |
Schizophrenia, sleep disturbances and the suprachiasmatic nucleus: reduced nitric oxide synthase may matter.
Topics: Continuous Positive Airway Pressure; Delusions; Humans; Light; Melatonin; Models, Biological; Nitric | 2010 |
Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome?
Topics: Adult; Aged; Aged, 80 and over; Chronobiology Disorders; Female; Humans; Liver Cirrhosis; Male; Mela | 2009 |
Effects of Ramadan fasting on physical performance and metabolic, hormonal, and inflammatory parameters in middle-distance runners.
Topics: Adult; Affect; Athletic Performance; Energy Metabolism; Epinephrine; Fasting; Fatigue; Hormones; Hum | 2009 |
Altered sleep architecture and higher incidence of subsyndromal depression in low endogenous melatonin secretors.
Topics: Adolescent; Adult; Circadian Rhythm; Depression; Enzyme-Linked Immunosorbent Assay; Female; Humans; | 2010 |
Melatonin rhythms in patients with cirrhosis.
Topics: Adult; Aged; Aged, 80 and over; Circadian Rhythm; Female; Hepatitis C, Chronic; Humans; Liver Cirrho | 2010 |
The role of environmental light in sleep and health: effects of ocular aging and cataract surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cataract Extraction; Child; Circadian | 2010 |
On the origin and the consequences of circadian abnormalities in patients with cirrhosis.
Topics: Actigraphy; Adult; Aged; Aged, 80 and over; Case-Control Studies; Circadian Rhythm; Female; Humans; | 2010 |
[Clinical experiences with agomelatine. The inner ear has to be synchronized again].
Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Controlled Clinical Trials as Topic; Depression | 2010 |
Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams.
Topics: Animals; Animals, Newborn; Antigens, Bacterial; Anxiety; Arthritis, Experimental; Behavior, Animal; | 2010 |
Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression.
Topics: Adult; Body Temperature; Circadian Rhythm; Depression; Female; Humans; Male; Melatonin; Middle Aged; | 2010 |
Sleep disturbance and melatonin levels following traumatic brain injury.
Topics: Adult; Anxiety; Area Under Curve; Brain Injuries; Case-Control Studies; Depression; Electroencephalo | 2010 |
Evaluation of melatonin on the precocious puberty: a pilot study.
Topics: Child; Child Development; Child, Preschool; Female; Gonadal Steroid Hormones; Humans; Melatonin; Pil | 2011 |
Relation of melatonin to sleep architecture in children with autism.
Topics: Autistic Disorder; Child; Child, Preschool; Female; Humans; Male; Melatonin; Polysomnography; Sleep; | 2011 |
Sleep in older adults with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Caregivers; Causality; Exercise; Family; Geriatric Assessment; Human | 2010 |
Effectiveness of melatonin for sleep problems in autism spectrum disorders: evidence grows but research is still needed.
Topics: Central Nervous System Depressants; Child Development Disorders, Pervasive; Female; Humans; Male; Me | 2011 |
[Sleep disturbances in Smith-Magenis syndrome: treatment with melatonin and beta-adrenergic antagonists].
Topics: Adrenergic beta-Antagonists; Child, Preschool; Chromosome Deletion; Chromosomes, Human, Pair 17; Chr | 2010 |
[Burden and health effects of shift work].
Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Germany; Health; Humans; Melatonin; Occupationa | 2010 |
Phase relationship between skin temperature and sleep-wake rhythms in women with vascular dysregulation and controls under real-life conditions.
Topics: Adult; Circadian Rhythm; Female; Health Status; Humans; Melatonin; Patient Selection; Saliva; Saliva | 2010 |
Headset Bluetooth and cell phone based continuous central body temperature measurement system.
Topics: Air; Algorithms; Body Temperature; Cell Phone; Computer Communication Networks; Electronics; Humans; | 2010 |
Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.
Topics: Acetylserotonin O-Methyltransferase; Case-Control Studies; Genetic Testing; Humans; Intellectual Dis | 2011 |
No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type | 2011 |
Liquid melatonin via gastrostomy as an alternative hypnotic in a child with pervasive developmental disorder.
Topics: Central Nervous System Depressants; Child Development Disorders, Pervasive; Child, Preschool; Gastro | 2011 |
Physical activity, sedentary behavior, and melatonin among rotating shift nurses.
Topics: Adult; Alcohol Drinking; Body Weight; Energy Metabolism; Female; Humans; Melatonin; Middle Aged; Mot | 2011 |
Melatonin for sleep-disturbed children with autism spectrum disorders: can we really speak of a substitution treatment?
Topics: Child Development Disorders, Pervasive; Humans; Melatonin; Sleep Wake Disorders | 2011 |
Older poor-sleeping women display a smaller evening increase in melatonin secretion and lower values of melatonin and core body temperature than good sleepers.
Topics: Adult; Aged; Aged, 80 and over; Aging; Body Temperature; Circadian Rhythm; Cross-Sectional Studies; | 2011 |
The pineal hormone melatonin in health and disease.
Topics: Humans; Melatonin; Neoplasms; Neurodegenerative Diseases; Pineal Gland; Sleep Wake Disorders | 2011 |
Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis.
Topics: Adult; Circadian Rhythm; Enzyme-Linked Immunosorbent Assay; Fatigue; Female; Humans; Interferon beta | 2012 |
Effects of melatonin should be studied separately in each neurodevelopmental disorder and with specific sleep diagnoses.
Topics: Antioxidants; Developmental Disabilities; Female; Humans; Male; Melatonin; Mental Disorders; Sleep W | 2012 |
Melatonin concentration as a marker of the circadian phase in patients with obstructive sleep apnoea.
Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Lighting; Male; Melatonin; Middle Aged; Polysom | 2012 |
Dim light melatonin onset in alcohol-dependent men and women compared with healthy controls.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Case-Control Studies; Female; Humans; Light; Male; Melato | 2012 |
Diurnal melatonin patterns in children: ready to apply in clinical practice?
Topics: Adolescent; Age Factors; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Male; Melatonin; | 2012 |
Effect of melatonin and caffeine interaction on caffeine induced oxidative stress and sleep disorders.
Topics: Animals; Caffeine; Drug Combinations; Drug Interactions; Melatonin; Oxidative Stress; Random Allocat | 2010 |
Complete absence of evening melatonin increase in tetraplegics.
Topics: Adult; Case-Control Studies; Circadian Rhythm; Cross-Sectional Studies; Humans; Male; Melatonin; Mid | 2012 |
Potential of melatonin for the treatment or prevention of obesity: an urgent need to include weight reduction as a secondary outcome in clinical trials of melatonin in obese patients with sleep disorders.
Topics: Central Nervous System Depressants; Clinical Trials as Topic; Humans; Melatonin; Obesity; Sleep Wake | 2012 |
Sleep and sleep disorders in the hospital.
Topics: Circadian Rhythm; Hospitalization; Humans; Melatonin; Polysomnography; Respiration, Artificial; Slee | 2012 |
Sleep disturbance after pinealectomy in patients with pineocytoma WHO°I.
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Pineal Gland; Pinealoma; Sleep; Sleep Init | 2012 |
Treatment of sleep disorders with melatonin.
Topics: Central Nervous System Diseases; Developmental Disabilities; Female; Humans; Male; Melatonin; Sleep; | 2012 |
Sleep/wake cycles in the dark: sleep recorded by polysomnography in 26 totally blind subjects compared to controls.
Topics: Adult; Blindness; Darkness; Female; Humans; Male; Marital Status; Melatonin; Middle Aged; Occupation | 2002 |
Spontaneous central melatonin secretion and resorption kinetics of exogenous melatonin: a ventricular CSF study.
Topics: Cerebral Ventricles; Cerebrospinal Fluid Shunts; Child, Preschool; Chloral Hydrate; Female; Humans; | 2002 |
[Combined use of melatonin and low-dose flunitrazepam for treatment of sleep disturbance in a child with spastic quadriplegia: evaluation using polysomnography].
Topics: Adolescent; Anti-Anxiety Agents; Circadian Rhythm; Drug Therapy, Combination; Evaluation Studies as | 2002 |
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome.
Topics: Alleles; Amino Acid Motifs; Amino Acid Substitution; Arylamine N-Acetyltransferase; Binding Sites; C | 2003 |
Re: Mann--melatonin for ulcerative colitis?
Topics: Adjuvants, Immunologic; Child; Colitis, Ulcerative; Digestive System Diseases; Humans; Melatonin; Sl | 2003 |
Sleep disorders.
Topics: Adult; Aged; Antioxidants; Cheyne-Stokes Respiration; Chronobiology Disorders; Chronotherapy; Disord | 2003 |
[Melatonin: warnings on uncontrolled use].
Topics: Clinical Trials as Topic; Female; Humans; Male; Melatonin; Meta-Analysis as Topic; Research; Retrosp | 2003 |
[Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome].
Topics: Abnormalities, Multiple; Adolescent; Adrenergic beta-Antagonists; Child; Child, Preschool; Chromosom | 2003 |
Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics.
Topics: Adult; Alcohol Drinking; Alcoholism; Body Mass Index; Case-Control Studies; Electroencephalography; | 2003 |
[Diagnosis and treatment of sleep disorders related to psychiatry].
Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Polysomnography; Psychiatry; Sleep Initiation and | 2004 |
Comment on 'Melatonin as a hypnotic: con'.
Topics: Animals; Arousal; Dose-Response Relationship, Drug; Humans; Hypnotics and Sedatives; Melatonin; Slee | 2005 |
The effect of traumatic brain injury on the timing of sleep.
Topics: Adult; Biological Clocks; Brain Injuries; Chronobiology Phenomena; Circadian Rhythm; Female; Humans; | 2005 |
Urinary 6-hydroxymelatonin sulfate excretion in intellectually disabled subjects with sleep disorders and multiple medications: validation of measurements in urine extracted from diapers.
Topics: Adolescent; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Disable | 2005 |
Melatonin for patients with asthma: safety and efficacy are still dubious.
Topics: Asthma; Female; Humans; Melatonin; Research Design; Safety; Sleep Wake Disorders | 2005 |
Melatonin in critically ill patients.
Topics: Adult; Critical Care; Humans; Male; Melatonin; Respiratory Distress Syndrome; Sepsis; Sleep Wake Dis | 2005 |
Melatonin, sleep, and shift work adaptation.
Topics: Accidents, Occupational; Adaptation, Physiological; Adult; Circadian Rhythm; Fatigue; Female; Humans | 2005 |
Melatonin: a novel treatment for IBS?
Topics: Adaptation, Physiological; Humans; Irritable Bowel Syndrome; Melatonin; Mood Disorders; Polysomnogra | 2005 |
Melatonin and epilepsy.
Topics: Adolescent; Adult; Child; Epilepsy; Humans; Melatonin; Retrospective Studies; Sleep Wake Disorders | 2005 |
A chronopharmacological preventive treatment for sleep-related migraine headaches and chronic morning headaches: Nitric oxide supersensitivity can cause sleep-related headaches in a subset of patients.
Topics: Antioxidants; Headache Disorders; Humans; Hydrocortisone; Melatonin; Migraine Disorders; Moclobemide | 2006 |
Sleep disturbance in Sanfilippo syndrome: a parental questionnaire study.
Topics: Adolescent; Adult; Age of Onset; Behavior Therapy; Child; Child, Preschool; Humans; Incidence; Infan | 2005 |
Does melatonin help people sleep?
Topics: Humans; Melatonin; Randomized Controlled Trials as Topic; Sleep Wake Disorders | 2006 |
Sleep problems and information processing, a "disconnection effect" in autism?
Topics: Autistic Disorder; Brain; Cognition; Cognition Disorders; Humans; Information Storage and Retrieval; | 2006 |
Does melatonin improve sleep? Muddles with melatonin.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders | 2006 |
Does melatonin improve sleep? Efficacy of melatonin.
Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep Wake Disorders; Treatment Outcome; Work | 2006 |
It's Erren's brainchild, folks!
Topics: Breast Neoplasms; Female; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2006 |
The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: a case report.
Topics: Adult; Circadian Rhythm; Electronic Data Processing; Humans; Light; Male; Melatonin; Monitoring, Phy | 2006 |
An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism.
Topics: Administration, Oral; Autistic Disorder; Child; Child, Preschool; Comorbidity; Cross-Sectional Studi | 2006 |
Polymorphonuclear leucocyte priming in long intermittent nocturnal haemodialysis patients--is melatonin a player?
Topics: Chronic Disease; Circadian Rhythm; Female; Humans; Kidney Diseases; Male; Melatonin; Middle Aged; Ne | 2006 |
Sleep in dementia assessment may require a multidisciplinary approach.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arousal; Combined Modality Therapy; Double-Blind Method; | 2006 |
Melatonin and sleep disorders: no better than placebo.
Topics: Humans; Melatonin; Meta-Analysis as Topic; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders | 2006 |
Cognitive performance following premature awakening from zolpidem or melatonin induced daytime sleep.
Topics: Adjuvants, Immunologic; Adult; Circadian Rhythm; Clinical Trials as Topic; Cognition; Cognition Diso | 2007 |
[Melatonin: physiological and pathophysiological aspects and possible applications].
Topics: Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders | 2006 |
[Melatonin: physiological and pathophysiological aspects and possible applications].
Topics: Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders; Whiplash Injuries | 2006 |
Biochemical and body composition analysis of nocturia in the elderly.
Topics: Adult; Age Factors; Aged; Biomarkers; Blood Pressure; Body Composition; Catecholamines; Circadian Rh | 2008 |
Sleep all day!
Topics: Chronobiology Disorders; Dietary Supplements; Humans; Melatonin; Sleep Wake Disorders; United States | 2006 |
Self-reported sleep latency in postmenopausal women.
Topics: Aged; Aged, 80 and over; Circadian Rhythm; Female; Humans; Melatonin; Middle Aged; Postmenopause; Sl | 2007 |
Comment to the paper of Medeiros CAM, et al. (2007) J Neurol 254:459-464.
Topics: Antiparkinson Agents; Central Nervous System Depressants; Circadian Rhythm; Drug Administration Sche | 2008 |
Day-time naps and melatonin in blind people.
Topics: Blindness; Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders | 1995 |
[Melatonin treatment for sleep-wake disorder--an experience for a severely mental retarded patient with blindness].
Topics: Administration, Oral; Blindness; Child; Circadian Rhythm; Humans; Intellectual Disability; Male; Mel | 1995 |
Melatonin treatment of a non-24-hour sleep-wake cycle in a blind retarded child.
Topics: Blindness; Child, Preschool; Chromosomes, Human, Pair 22; Circadian Rhythm; Dose-Response Relationsh | 1995 |
Travel statement on jet lag. Committee to Advise on Tropical Medicine and Travel (CATMAT).
Topics: Benzodiazepines; Canada; Circadian Rhythm; Humans; Melatonin; Phototherapy; Sleep Wake Disorders; Tr | 1995 |
Circadian rhythm studies in neuronal ceroid-lipofuscinosis (NCL).
Topics: Adolescent; Adult; Analysis of Variance; Body Temperature; Child; Child, Preschool; Circadian Rhythm | 1995 |
Melatonin and delayed sleep phase syndrome: ambulatory polygraphic evaluation.
Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Polysomnography; | 1994 |
Melatonin treatment of chronic sleep disorders.
Topics: Administration, Oral; Chronic Disease; Humans; Melatonin; Sleep Wake Disorders; Treatment Outcome; W | 1995 |
Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome.
Topics: Adult; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Sleep Wake Disorders | 1995 |
Sleep disorders and melatonin rhythms in elderly people.
Topics: Adult; Aged; Aged, 80 and over; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep Wake Disord | 1994 |
Melatonin and hormonal changes in disturbed sleep during late pregnancy.
Topics: Adult; Circadian Rhythm; Female; Humans; Hydrocortisone; Melatonin; Pregnancy; Pregnancy Complicatio | 1993 |
Successful use of S20098 and melatonin in an animal model of delayed sleep-phase syndrome (DSPS).
Topics: Acetamides; Animals; Circadian Rhythm; Disease Models, Animal; Hypnotics and Sedatives; Male; Melato | 1993 |
Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake schedule.
Topics: Blindness; Body Temperature; Circadian Rhythm; Humans; Hydrocortisone; Light; Male; Melatonin; Middl | 1993 |
Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders.
Topics: Adolescent; Adult; Axilla; Body Temperature Regulation; Child; Circadian Rhythm; Epilepsy; Female; H | 1993 |
[Case report: treatment of a patient with sleep phase advance disorder with phototherapy].
Topics: Adult; Body Temperature Regulation; Circadian Rhythm; Humans; Hydrocortisone; Male; Melatonin; Photo | 1995 |
Melatonin.
Topics: Aging; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 1996 |
Liver cirrhosis and circadian rhythm.
Topics: Circadian Rhythm; Humans; Liver Cirrhosis; Melatonin; Sleep Wake Disorders | 1996 |
Melatonin for sleep problems.
Topics: Adolescent; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatonin | 1996 |
Can melatonin cause severe headaches?
Topics: Adult; Headache; Humans; Male; Melatonin; Self Medication; Sleep Wake Disorders | 1996 |
Daily rhythm of serum melatonin in patients with dementia of the degenerate type.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Circadian Rhythm; Dementia; Female; Humans; Male; Melato | 1996 |
[Synchronization of the biological clock in a disordered sleep-wakefulness rythm].
Topics: Adult; Child; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Humans; Male; Melatonin; Mi | 1996 |
Studies of sleep in strange places may benefit people with common ills.
Topics: Circadian Rhythm; Humans; Light; Melatonin; Research; Sleep; Sleep Wake Disorders; Space Flight; Sub | 1996 |
[Melatonin--uncritical use after unserious advertising].
Topics: Adult; Advertising; Drug Information Services; Drug Prescriptions; Humans; Male; Melatonin; Sleep; S | 1996 |
Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment.
Topics: Adult; Circadian Rhythm; Humans; Light; Male; Melatonin; Sleep Wake Disorders; Wakefulness | 1996 |
[Melatonin: a new wonder drug?].
Topics: Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders; Work Schedule Tolerance | 1996 |
[On the problem of regulating the biological rhythms of the body].
Topics: Biological Clocks; Humans; Melatonin; Periodicity; Physical Therapy Modalities; Pineal Gland; Sleep | 1996 |
Restoration of detectable melatonin after entrainment to a 24-hour schedule in a 'free-running' man.
Topics: Adult; Body Temperature Regulation; Circadian Rhythm; Dark Adaptation; Humans; Hydrocortisone; Hypot | 1997 |
Free-running circadian rhythm of melatonin in a sighted man despite a 24-hour sleep pattern: a non-24-hour circadian syndrome.
Topics: Adult; Circadian Rhythm; Humans; Light; Longitudinal Studies; Male; Melatonin; Sleep Stages; Sleep W | 1997 |
A sighted man with non-24-hour sleep-wake syndrome shows damped plasma melatonin rhythm.
Topics: Adult; Body Temperature; Circadian Rhythm; Humans; Hydrocortisone; Longitudinal Studies; Male; Melat | 1997 |
Daily melatonin intake resets circadian rhythms of a sighted man with non-24-hour sleep-wake syndrome who lacks the nocturnal melatonin rise.
Topics: Administration, Oral; Adult; Body Temperature; Circadian Rhythm; Humans; Hydrocortisone; Longitudina | 1997 |
Controversies in sleep medicine: melatonin.
Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders | 1997 |
Melatonin treatment of chronic sleep disorders.
Topics: Child; Humans; Melatonin; Sleep Wake Disorders | 1998 |
[Chronic fatigue syndrome].
Topics: Adult; Antioxidants; Child; Diagnosis, Differential; Fatigue Syndrome, Chronic; Female; Humans; Mela | 1997 |
Continuous measurement of temperature in non-24 hour sleep-wake syndrome.
Topics: Adult; Arousal; Body Temperature Regulation; Circadian Rhythm; Humans; Male; Melatonin; Monitoring, | 1998 |
Melatonin treatment for circadian rhythm sleep disorders.
Topics: Adolescent; Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Humans; Male; Melaton | 1998 |
Trials of bright light exposure and melatonin administration in a patient with non-24 hour sleep-wake syndrome.
Topics: Adult; Circadian Rhythm; Combined Modality Therapy; Humans; Male; Melatonin; Phototherapy; Sleep Sta | 1998 |
Melatonin treatment for rhythm disorder.
Topics: Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Humans; Male; Melatonin; Sleep St | 1998 |
Free-running of plasma melatonin rhythm prior to full manifestation of a non-24 hour sleep-wake syndrome.
Topics: Administration, Oral; Adult; Circadian Rhythm; Humans; Male; Melatonin; Polysomnography; Psychophysi | 1998 |
Pro-convulsant effects of oral melatonin in neurologically disabled children.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Humans; Infant; Melatonin; Neuromuscular | 1998 |
What is melatonin? Is it a useful treatment for sleep problems in autism?
Topics: Autistic Disorder; Humans; Melatonin; Sleep Wake Disorders | 1998 |
The use of melatonin as a potential treatment for shiftwork sleep disorder.
Topics: Emergency Medical Services; Humans; Melatonin; Sleep Wake Disorders; Work Schedule Tolerance | 1998 |
Melatonin treatment in an institutionalised child with psychomotor retardation and an irregular sleep-wake pattern.
Topics: Adolescent; Adolescent, Institutionalized; Female; Humans; Melatonin; Monitoring, Ambulatory; Psycho | 1998 |
Fibromyalgia and melatonin: are they related?
Topics: Circadian Rhythm; Fibromyalgia; Humans; Insulin-Like Growth Factor I; Melatonin; Pineal Gland; Seaso | 1998 |
Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep-wake rhythm disorders.
Topics: Adult; Chronic Disease; Circadian Rhythm; Humans; Male; Melatonin; Middle Aged; Radioimmunoassay; Sl | 1998 |
Monozygotic twins with Alzheimer's disease treated with melatonin: Case report.
Topics: Aged; Alzheimer Disease; Antioxidants; Brain; Diseases in Twins; Humans; Magnetic Resonance Imaging; | 1998 |
[Melatonin: myth or reality?].
Topics: Adjuvants, Immunologic; Adult; Animals; Antioxidants; Cattle; Child; Contraindications; Controlled C | 1998 |
Melatonin rhythms in delayed sleep phase syndrome.
Topics: Adolescent; Adult; Body Temperature; Circadian Rhythm; Female; Habits; Humans; Male; Melatonin; Slee | 1999 |
Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Case-Control Studies; Circadian Rhythm; Confounding F | 1999 |
Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome.
Topics: Adolescent; Child; Female; Humans; Kinetics; Melatonin; Rett Syndrome; Sleep; Sleep Wake Disorders; | 1999 |
Managing fatigue in operational settings 1: Physiological considerations and counter-measures.
Topics: Aviation; Circadian Rhythm; Diet; Exercise; Fatigue; Humans; Melatonin; Occupational Health; Personn | 1997 |
A 50-Hz electromagnetic field impairs sleep.
Topics: Adolescent; Adult; Circadian Rhythm; Electromagnetic Fields; Female; Growth Hormone; Humans; Hydroco | 1999 |
[The jet lag syndrome].
Topics: Circadian Rhythm; Humans; Italy; Melatonin; Phototherapy; Sleep Wake Disorders; Sports; Syndrome; Tr | 1999 |
Circadian rhythm sleep disorder associated with pontine lesion.
Topics: Circadian Rhythm; Humans; Magnetic Resonance Imaging; Male; Melatonin; Middle Aged; Pons; Sleep Wake | 1999 |
Circadian rhythm sleep disorders in adolescents: clinical trials of combined treatments based on chronobiology.
Topics: Absenteeism; Adolescent; Chronotherapy; Combined Modality Therapy; Female; Humans; Male; Melatonin; | 1998 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation.
Topics: Adult; Aged; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1999 |
[Effect of melatonin sleep disturbance in a case with periodic ACTH-ADH discharge syndrome].
Topics: Adrenocorticotropic Hormone; Child; Humans; Male; Melatonin; Sleep Wake Disorders; Vasopressins; Vom | 1999 |
Sleep and activity rhythms are related to circadian phase in the blind.
Topics: Adult; Aged; Blindness; Circadian Rhythm; Female; Fourier Analysis; Homeostasis; Humans; Male; Melat | 1999 |
Poor recovery sleep after sleep deprivation in delayed sleep phase syndrome.
Topics: Adult; Circadian Rhythm; Homeostasis; Humans; Male; Melatonin; Reference Values; Sleep Deprivation; | 1999 |
New day dawns for research on circadian rhythms.
Topics: Affect; Biological Clocks; Circadian Rhythm; Feedback; Free Radical Scavengers; Humans; Lighting; Me | 1999 |
Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans.
Topics: Activity Cycles; Adult; Aged; Child; Circadian Rhythm; Europe; Family Health; Female; Genes, Dominan | 1999 |
Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.
Topics: Alleles; Amino Acid Substitution; Base Sequence; Circadian Rhythm; Cloning, Molecular; DNA Primers; | 1999 |
Comparison between subjective and actigraphic measurement of sleep and sleep rhythms.
Topics: Circadian Rhythm; Female; Free Radical Scavengers; Humans; Male; Melatonin; Middle Aged; Polysomnogr | 1999 |
EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss.
Topics: Adult; Circadian Rhythm; Electroencephalography; Eye Movements; Humans; Male; Melatonin; Sleep Wake | 1999 |
Jet lag. A problem for 'long haul' travellers.
Topics: Benzodiazepines; Circadian Rhythm; Humans; Male; Melatonin; Sleep Wake Disorders; Travel; Treatment | 1999 |
Do plasma melatonin concentrations decline with age?
Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep Wake | 1999 |
Melatonin to treat fragmented sleep needs study.
Topics: Child; Developmental Disabilities; Humans; Intelligence; Melatonin; Sleep Wake Disorders | 1999 |
[Melatonin and time zone transition].
Topics: Circadian Rhythm; Gastrointestinal Diseases; Humans; Melatonin; Pituitary Gland; Sensitivity and Spe | 1996 |
Sleep disorder in Rett syndrome and melatonin treatment.
Topics: Anticonvulsants; Child; Female; Humans; Melatonin; Rett Syndrome; Sleep Wake Disorders | 1999 |
Changes in melatonin concentrations during IFN therapy.
Topics: Hepatitis C, Chronic; Humans; Interferons; Melatonin; Sleep Wake Disorders | 1999 |
Melatonin.
Topics: Drug Interactions; Headache; Humans; Jet Lag Syndrome; Melatonin; Neoplasms; Sleep Wake Disorders | 1999 |
'Melatonin treatment of sleep-wake cycle disorders in children and adolescents'.
Topics: Adolescent; Antioxidants; Child; Child, Preschool; Humans; Melatonin; Sleep Wake Disorders; Treatmen | 1999 |
A new concept for melatonin deficit: on pineal calcification and melatonin excretion.
Topics: Adolescent; Adult; Aged; Calcinosis; Female; Humans; Male; Melatonin; Middle Aged; Pineal Gland; Ref | 1999 |
Melatonin and aging: relevance for clinical approach?
Topics: Action Potentials; Aging; Circadian Rhythm; Humans; Male; Melatonin; Neocortex; Receptors, Cell Surf | 1999 |
Low melatonin production in infants with a life-threatening event.
Topics: Acute Disease; Case-Control Studies; Female; Humans; Infant; Infant, Newborn; Male; Melatonin; Nucle | 2000 |
Melatonin secretion after surgery.
Topics: Adult; Circadian Rhythm; Female; Humans; Hysterectomy; Melatonin; Middle Aged; Postoperative Complic | 2000 |
Circadian and sleep disturbances in the elderly.
Topics: Aged; Aging; Circadian Rhythm; Humans; Melatonin; Photoperiod; Sleep; Sleep Wake Disorders; Suprachi | 2000 |
Melatonin in older people with age-related sleep maintenance problems: a comparison with age matched normal sleepers.
Topics: Aged; Aged, 80 and over; Aging; Case-Control Studies; Female; Humans; Male; Melatonin; Sleep Wake Di | 2001 |
Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome.
Topics: Abnormalities, Multiple; Adolescent; Case-Control Studies; Child; Child Behavior Disorders; Child, P | 2001 |
Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment.
Topics: Adult; Affect; Antidepressive Agents; Circadian Rhythm; Clomipramine; Depression; Female; Humans; Ma | 2001 |
[Melatonin as a drug].
Topics: Administration, Oral; Dose-Response Relationship, Drug; Humans; Melatonin; Patient Satisfaction; Sle | 1997 |
beta(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome.
Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Behavior; Child; Child, Preschool; Chromosomes, | 2001 |
Methylphenidate and melatonin for sleep disorder with optic glioma.
Topics: Anticonvulsants; Child; Circadian Rhythm; Dopamine Agents; Drug Therapy, Combination; Humans; Male; | 2001 |
Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels.
Topics: Aged; Arrhythmias, Cardiac; Autoantibodies; Brain; Circadian Rhythm; Electroencephalography; Electro | 2001 |
[Sleep disorders and the 24-hour profile of melatonin and cortisol].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Hydrocortisone; | 2000 |
Sleep-wake schedule disorder disability: a lifelong untreatable pathology of the circadian time structure.
Topics: Adult; Chronotherapy; Circadian Rhythm; Craniocerebral Trauma; Humans; Male; Melatonin; Sleep Wake D | 2001 |
[Sleeping sickness: major disorders of circadian rhythm].
Topics: Circadian Rhythm; Human Growth Hormone; Humans; Hydrocortisone; Melatonin; Prolactin; Renin; Sleep W | 2001 |
Sleep and supplements: the great melatonin debate.
Topics: Aged; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2002 |
[Disorders of circadian rhythms in depression].
Topics: Adrenocorticotropic Hormone; Circadian Rhythm; Depressive Disorder; Growth Hormone-Releasing Hormone | 1992 |
The importance of timing in melatonin administration in a blind man.
Topics: Adolescent; Blindness; Circadian Rhythm; Drug Administration Schedule; Humans; Male; Melatonin; Slee | 1992 |
Colic, sleep inertia, melatonin and circannual rhythms.
Topics: Colic; Crying; Female; Fetus; Geography; Humans; Infant; Infant, Newborn; Maternal-Fetal Exchange; M | 1992 |
The delayed sleep phase syndrome: clinical and investigative findings in 14 subjects.
Topics: Adolescent; Adult; Aged; Behavior Therapy; Cataplexy; Circadian Rhythm; Combined Modality Therapy; F | 1992 |
Vitamin B12 treatment for sleep-wake rhythm disorders.
Topics: Adolescent; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melatonin; Middle Aged; | 1990 |
The therapeutic potential for tryptophan and melatonin: possible roles in depression, sleep, Alzheimer's disease and abnormal aging.
Topics: Aging; Animals; Bipolar Disorder; Dementia; Depressive Disorder; Humans; Melatonin; Mental Disorders | 1990 |
A portable light source for bright light treatment.
Topics: Adult; Circadian Rhythm; Humans; Lighting; Male; Melatonin; Mood Disorders; Phototherapy; Sleep Wake | 1990 |
Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms.
Topics: Blindness; Body Temperature Regulation; Circadian Rhythm; Humans; Hydrocortisone; Male; Melatonin; M | 1990 |
Jet lag and its pharmacology.
Topics: Adaptation, Physiological; Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Middle Aged | 1986 |
Delayed recovery of sleep and melatonin rhythms after nightshift work in Antarctic winter.
Topics: Antarctic Regions; Circadian Rhythm; Humans; Male; Melatonin; Seasons; Sleep Wake Disorders; Time Fa | 1986 |
Synchronisation of a disturbed sleep-wake cycle in a blind man by melatonin treatment.
Topics: Blindness; Circadian Rhythm; Humans; Male; Melatonin; Middle Aged; Sleep Wake Disorders | 1988 |
The use of plasma melatonin levels and light in the assessment and treatment of chronobiologic sleep and mood disorders.
Topics: Biological Clocks; Humans; Intraocular Pressure; Light; Melatonin; Mood Disorders; Phototherapy; Sea | 1986 |
Neuroendocrine rhythms in a patient with the Kleine-Levin syndrome.
Topics: Adolescent; Circadian Rhythm; Disorders of Excessive Somnolence; Feeding and Eating Disorders; Femal | 1985 |
Treating phase typed chronobiologic sleep and mood disorders using appropriately timed bright artificial light.
Topics: Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Seasons; Sleep Wake Disorders | 1985 |