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melatonin and Sleep Disorders, Circadian Rhythm

melatonin has been researched along with Sleep Disorders, Circadian Rhythm in 358 studies

Sleep Disorders, Circadian Rhythm: Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.

Research Excerpts

ExcerptRelevanceReference
" All papers on melatonin treatment in dementia were retrieved."8.86Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010)
"Melatonin is used to treat sleep disorders in both children and adults with intellectual disability (ID), although it has no product license for such use."8.84Melatonin and sleep disorders associated with intellectual disability: a clinical review. ( Clarke, D; Sajith, SG, 2007)
"Sleep disturbances, abnormal melatonin secretion, and increased inflammation are aspects of autism spectrum disorder (ASD) pathophysiology."8.02Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances. ( Anderson, G; da Silveira Cruz-Machado, S; Fadini, CC; Guissoni Campos, LM; Markus, RP; Pinato, L, 2021)
"To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR)."7.91Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy. ( Andersen, HU; Ba-Ali, S; Brøndsted, AE; Jennum, PJ; Lund-Andersen, H; Sander, B, 2019)
"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."7.91Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies."7.73Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin. ( Abad, A; Carpizo, R; González, M; Martínez, A; Mediavilla, D; Sánchez-Barceló, EJ, 2006)
"Small doses of melatonin were administrated to 30 patients with day/night rhythm disorders, after cerebral stroke."7.70[Melatonin in sleep rhythm disorders after cerebral stroke]. ( Domzał, TM; Kaca-Oryńska, M; Zaleski, P, 2000)
"Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime."6.71Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."6.46Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"Treatment with melatonin up to 14 mg at bedtime was initiated with complete realignment of the sleep-wake rhythm (tau 23."5.46Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst. ( Antelmi, E; Ferri, L; Filardi, M; Moresco, M; Pierangeli, G; Pizza, F; Plazzi, G; Toni, F; Vandi, S; Zucchelli, M, 2017)
"Williams-Beuren syndrome (WBS), a neurodevelopmental disorder caused by a microdeletion on chromosomic region 7q11."5.43Correlations between behavior, memory, sleep-wake and melatonin in Williams-Beuren syndrome. ( Campos, LM; Giacheti, CM; Pinato, L; Rossi, NF; Santoro, SD, 2016)
"Melatonin treatment significantly reduced depression scores in the depressed patients as measured by the CES-D and Hamilton Depression Rating Scale--17."5.14Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. ( Kayumov, L; Rahman, SA; Shapiro, CM, 2010)
" These have been variously attributed to hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pathophysiology remains limited and their treatment problematic."4.90Sleep-wake abnormalities in patients with cirrhosis. ( Amodio, P; Corrias, M; Costa, R; De Pittà, C; De Rui, M; Gatta, A; Merkel, C; Montagnese, S; Skene, DJ; Turco, M, 2014)
"PubMed database was searched systematically for articles that were published on or before May 5, 2013, and were written in English using the terms bipolar disorder, clock genes, endogenous clock, molecular clock, biological rhythms, circadian, suprachiasmatic nucleus, circadian rhythm, melatonin, and sleep."4.90The relationship between bipolar disorder and biological rhythms. ( Gonzalez, R, 2014)
" We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol and melatonin), and we assess the implications for CT and adjustment to shiftwork and jet lag."4.88Circadian typology: a comprehensive review. ( Adan, A; Archer, SN; Di Milia, L; Hidalgo, MP; Natale, V; Randler, C, 2012)
" All papers on melatonin treatment in dementia were retrieved."4.86Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010)
"Melatonin is used to treat sleep disorders in both children and adults with intellectual disability (ID), although it has no product license for such use."4.84Melatonin and sleep disorders associated with intellectual disability: a clinical review. ( Clarke, D; Sajith, SG, 2007)
"Sleep disturbances, abnormal melatonin secretion, and increased inflammation are aspects of autism spectrum disorder (ASD) pathophysiology."4.02Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances. ( Anderson, G; da Silveira Cruz-Machado, S; Fadini, CC; Guissoni Campos, LM; Markus, RP; Pinato, L, 2021)
"To investigate potential delays in endogenous melatonin in individuals with obsessive-compulsive disorder (OCD)."3.96Sleep duration and timing in obsessive-compulsive disorder (OCD): evidence for circadian phase delay. ( Coles, ME; Deak, M; Schubert, J; Sharkey, KM; Stewart, E, 2020)
"To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR)."3.91Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy. ( Andersen, HU; Ba-Ali, S; Brøndsted, AE; Jennum, PJ; Lund-Andersen, H; Sander, B, 2019)
"Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR)."3.91Salivary melatonin onset in youth at familial risk for bipolar disorder. ( Armitage, R; Bertram, H; Fullerton, JM; Ghaziuddin, N; Glowinski, AL; Hulvershorn, LA; Kamali, M; McInnis, M; Mitchell, PB; Nurnberger, J; Roberts, GMP; Shamseddeen, W; Stapp, E; Wilcox, HC, 2019)
"To study disturbances of sleep and circadian rhythms in patients with cardiovascular diseases taking into account the level of melatonin secretion and to optimize a complex approach to their treatment."3.81[Sleep disorders and circadian rhythms in diseases of the cardiovascular system]. ( Eneeva, MA; Kamchatnov, PR; Kostenko, EV; Petrova, LV, 2015)
"We examined the relationship between sleep-wake activity, recorded actigraphically over 6 weeks, along with ambient light exposure and simultaneous circadian clock timing, by collecting weekly 48 h profiles of a urinary metabolite of melatonin in 20 out-patients with schizophrenia and 21 healthy control individuals matched for age, gender and being unemployed."3.78Sleep and circadian rhythm disruption in schizophrenia. ( Dijk, DJ; Foster, RG; Joyce, EM; Middleton, B; Wulff, K, 2012)
"Fourteen middle-aged individuals diagnosed with schizophrenia underwent continuous wrist actimetry monitoring in real-life settings for 3 weeks, and collected saliva samples to determine the onset of endogenous melatonin secretion as a circadian phase marker."3.77Sleep-wake cycles and cognitive functioning in schizophrenia. ( Bromundt, V; Cajochen, C; Georgiev-Kill, A; Köster, M; Opwis, K; Stoppe, G; Wirz-Justice, A, 2011)
"This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies."3.73Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin. ( Abad, A; Carpizo, R; González, M; Martínez, A; Mediavilla, D; Sánchez-Barceló, EJ, 2006)
"A patient with Gilles de la Tourette syndrome treated with haloperidol, ingested once daily after awakening from sleep, exhibited an irregular sleep-wake pattern with a free-running component of approximately 48 h."3.71Case study of circadian rhythm sleep disorder following haloperidol treatment: reversal by risperidone and melatonin. ( Ayalon, L; Dagan, Y; Hermesh, H, 2002)
"Small doses of melatonin were administrated to 30 patients with day/night rhythm disorders, after cerebral stroke."3.70[Melatonin in sleep rhythm disorders after cerebral stroke]. ( Domzał, TM; Kaca-Oryńska, M; Zaleski, P, 2000)
"This study reports on melatonin treatment in autism."3.70Effect of melatonin on sleep-wake rhythm: the sleep diary of an autistic male. ( Hayashi, E, 2000)
"Melatonin has also been found to have anticonvulsant and neuroprotective properties by adjusting the circadian rhythm."3.11Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. ( Chen, J; Feng, W; Liu, M; Shi, X; Sun, Y; Wang, J; Xu, T; Yang, G; Zou, L, 2022)
"Despite the separation of insomnia and circadian rhythm disorders in diagnostic nosology implying independent pathophysiology, there is considerable evidence of co-morbidity and interaction between them."3.01Circadian aspects in the aetiology and pathophysiology of insomnia. ( Lack, LC; Lovato, N; Micic, G, 2023)
"The main clinical manifestations are insomnia and excessive daytime sleepiness that often lead to clinically meaningful distress or cause mental, physical, social, occupational, educational, or other functional impairment."2.82Treatment of Circadian Rhythm Sleep-Wake Disorders. ( Chen, GH; Sun, SY, 2022)
"The outcomes showed decreased daytime sleepiness, lessened sleep onset latency, diminished night-time awakenings, increased total sleep period and improved daytime attention in the melatonin-treated group; (4) Conclusions: Exogenously administered melatonin is effective in shift worker health personnel that are suffering from sleep disorders, and given its low adverse effects and tolerability, it might be recommended."2.82The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review. ( Cantón-Manzano, C; Carriedo-Diez, B; Sanz-Valero, J; Tosoratto-Venturi, JL; Wanden-Berghe, C, 2022)
"Melatonin treatment during Trial 2 led to an improvement in the subjective sleep difficulty between the pre- and post-treatment surveys; however there were no significant differences in the objective measures of sleep."2.80Sleep deficits in the High Arctic summer in relation to light exposure and behaviour: use of melatonin as a countermeasure. ( Arendt, J; Brett, K; Hawton, A; Love, RJ; McCreary, DR; Paul, MA, 2015)
"Caffeine treatment significantly improved daytime alertness at adverse circadian phases (p <0."2.80Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms. ( Lockley, SW; St Hilaire, MA, 2015)
"Melatonin secretion was assayed for each individual by ELISA using saliva samples."2.74Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome. ( Kayumov, L; Rahman, SA; Shapiro, CM; Tchmoutina, EA, 2009)
"Treatment with melatonin resulted in an improvement of subjective and objective sleep parameters, as well as a recovered nocturnal melatonin rhythm."2.74The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study). ( Boringa, JB; Hagen, EC; Kerkhof, GA; Koch, BC; Nagtegaal, JE; Ter Wee, PM; van der Westerlaken, MM, 2009)
"However, unlike many patients with insomnia, those with DSPD struggle to get up at appropriate times."2.72Just Let Me Sleep in: Identifying and Treating Delayed Sleep Phase Disorder in Adolescents. ( Baroni, A; Feder, MA, 2021)
"Melatonin was initiated at the daily dose of 3 mg, at nocturnal bedtime."2.71Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. ( Coppola, G; Iervolino, G; La Torre, G; Mastrosimone, M; Pascotto, A; Ruiu, F, 2004)
"People with autism spectrum disorder (ASD) commonly experience other comorbidities."2.66Sleep in autism: A biomolecular approach to aetiology and treatment. ( Baker, EK; Ballester, P; Peiró, AM; Richdale, AL, 2020)
"Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies."2.55Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. ( Auld, F; Maschauer, EL; Morrison, I; Riha, RL; Skene, DJ, 2017)
" Management includes timed melatonin along with optional timed and dosed bright light exposure."2.55Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders. ( Burman, D, 2017)
"Treatment of circadian rhythm sleep disorders (CRSD) may include light therapy, chronotherapy and melatonin."2.50Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders. ( Curfs, LM; Duffy, JF; Keijzer, H; Smits, MG, 2014)
"Modafinil probably has similar effects on sleepiness (KSS) (MD -0."2.50Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. ( Costa, G; Driscoll, TR; Isotalo, LK; Liira, J; Ruotsalainen, JH; Sallinen, M; Verbeek, JH, 2014)
"The molecular effects of chronic sleep deprivation and circadian misalignment are currently being explored as potential mechanistic markers of the deleterious health consequences associated with these states."2.50Out of synch with society: an update on delayed sleep phase disorder. ( Dijk, DJ; Nesbitt, AD, 2014)
"sleep and mood), immune function, cancer initiation and growth, as well as the correlation between melatonin levels and cancer risk, are hereinafter recorded and summarized."2.49Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks. ( Antoniello, N; Faliva, MA; Perna, S; Rondanelli, M, 2013)
"Delayed sleep phase disorder (DSPD) - a circadian rhythm sleep disorder - is most commonly seen in adolescents."2.49Circadian rhythm disorders among adolescents: assessment and treatment options. ( Armstrong, SM; Bartlett, DJ; Biggs, SN, 2013)
"Primary pathophysiology of circadian rhythm sleep disorders(CRSDs) is a misalignment between the endogenous circadian rhythm phase and the desired or socially required sleep-wake schedule, or dysfunction of the circadian pacemaker and its afferent/efferent pathways."2.49[Circadian rhythm sleep disorder]. ( Mishima, K, 2013)
"This article reviews circadian rhythm sleep disorders (CRSDs) of children with neurodevelopmental disabilities."2.48Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities. ( Bax, MC; Ipsiroglu, OS; Jan, JE; Owens, JA; Wasdell, MB, 2012)
"True winter depression (SAD) appears to be rare, although subsyndromal SAD is reported."2.48Biological rhythms during residence in polar regions. ( Arendt, J, 2012)
"Search terms were "Alzheimer" "mild cognitive impairment" and "melatonin"."2.47The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease. ( Brusco, LI; Cardinali, DP; Furio, AM, 2011)
"Circadian rhythm sleep disorders are common conditions manifested as misalignment between the sleep period and the physical/social 24-h environmental cycle."2.46Circadian rhythm sleep disorders. ( Lenz, Mdo C; Martinez, D, 2010)
"Melatonin is a major chronobiological regulator involved in circadian phasing, sleep, and numerous other functions including cyto-/neuroprotection, immune modulation, and energy metabolism."2.46Investigational melatonin receptor agonists. ( Hardeland, R, 2010)
"In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity."2.46Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. ( Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V, 2010)
"Circadian rhythm sleep disorders are poorly understood and often misdiagnosed."2.46A circadian rhythm sleep disorder: melatonin resets the biological clock. ( Abbas, A; Milles, J; Raju, J; Ramachandran, S, 2010)
"Circadian rhythm sleep disorders are common in clinical practice."2.45A practical approach to circadian rhythm sleep disorders. ( Bjorvatn, B; Pallesen, S, 2009)
"The best-documented approaches to treating circadian rhythm sleep disorders are light and melatonin; physicians can easily administer both treatments."2.45[Circadian rhythm sleep disorders]. ( Bjorvatn, B; Pallesen, S, 2009)
"Different types of insomnia symptoms have been associated with abnormalities of the body temperature rhythm."2.44The relationship between insomnia and body temperatures. ( Gradisar, M; Lack, LC; Lushington, K; Van Someren, EJ; Wright, HR, 2008)
"Melatonin is a hormone, which is mainly produced by the pineal gland, a vestigial eye."2.44Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology. ( Brennan, R; Jan, JE; Lyons, CJ, 2007)
"Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical environment."2.44A clinical approach to circadian rhythm sleep disorders. ( Barion, A; Zee, PC, 2007)
"Difficulties with jet lag because of sleep loss and decreased performance are emphasised."2.44Jet lag: trends and coping strategies. ( Atkinson, G; Edwards, B; Reilly, T; Waterhouse, J, 2007)
"Melatonin has been shown to correct the underlying circadian rhythm abnormality as well as improve sleep and reduce daytime napping."2.44Circadian rhythm sleep disorders in the blind and their treatment with melatonin. ( Arendt, J; Skene, DJ, 2007)
"Patients with advanced sleep phase syndrome are sleepy in the evening and awaken very early and alert in the morning."2.44Circadian rhythmicity and the pharmacologic management of insomnia. ( Bramley, TJ; Mitrzyk, BM; Richardson, GS, 2007)
"Circadian rhythm sleep disorders are perhaps the most often overlooked conditions in the differential diagnosis of these symptoms."2.44Diagnosis of circadian rhythm sleep disorders. ( Lenz, Mdo C; Martinez, D; Menna-Barreto, L, 2008)
"Melatonin treatment significantly reduced sleep onset latency by 4."2.43Effects of exogenous melatonin on sleep: a meta-analysis. ( Ben-Shushan, A; Brzezinski, A; Ford, I; Norrie, G; Vangel, MG; Wurtman, RJ; Zhdanova, I, 2005)
"Individuals who have circadian rhythm sleep disorders present with symptoms of insomnia or excessive sleepiness and complain of an inability to sleep at their desired time."2.43Circadian rhythm sleep disorders. ( Burgess, HJ; Reid, KJ, 2005)
"Circadian rhythm sleep disorders, such as jet lag syndrome and shift work sleep disorder, are those specifically attributed to dysfunctions or insufficiencies in the circadian system."2.43The human circadian system in normal and disordered sleep. ( Richardson, GS, 2005)
"Melatonin has been successfully used to alleviate jet lag symptoms of travellers and there is also a smaller amount of evidence that the hormone helps shiftworkers adjust to nocturnal regimens."2.42The relevance of melatonin to sports medicine and science. ( Atkinson, G; Drust, B; Reilly, T; Waterhouse, J, 2003)
"Melatonin is a hormone produced in human by the pineal body, the endocrine gland localized in the central part of cerebrum."2.42[Melatonin and its biological significance]. ( Boguszewska, A; Pasternak, K, 2004)
"Melatonin is a hormone with powerful effects on behavior particularly circadian and sleep behavior."2.41Melatonin, sleep, and circadian rhythm disorders. ( Kayumov, L; Shapiro, CM; Zhdanova, IV, 2000)
"Melatonin treatment increased plasma melatonin concentration and restored circadian rhythm."1.91Melatonin Treatment of Circadian Rhythm Sleep-Wake Disorder in Obese Children Affects the Brain-Derived Neurotrophic Factor Level. ( Hu, B; Huang, X; Huang, Y, 2023)
"We also characterized mood states, daytime sleepiness, and sleep quality by questionnaires."1.91Sleep impairment and altered pattern of circadian biomarkers during a long-term Antarctic summer camp. ( Arantes, RME; Borges, L; Gonçalves, DAP; Hatanaka, E; Heller, D; Marques, AL; Mendes, TT; Moraes, MM; Núñez-Espinosa, C; Soares, DD; Wanner, SP, 2023)
"CRSWD are a distinct class of sleep disorders caused by alterations of the circadian time-keeping system, its entrainment mechanisms, or a misalignment of the endogenous circadian rhythm and the external environment."1.62Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities. ( Abbott, SM; Burgess, HJ; Crowley, SJ; Duffy, JF; Emens, JS; Epstein, LJ; Gamble, KL; Hasler, BP; Klerman, EB; Kristo, DA; Malkani, RG; Rahman, SA; Thomas, SJ; Wyatt, JK; Zee, PC, 2021)
"A novel therapy by total sleep deprivation followed by a combination of morning light therapy and nocturnal melatonin administration was efficient in stopping his free-running sleep-wake pattern both immediately and in the long term."1.62Sleep deprivation therapy to reset the circadian pacemaker in a non-24-hour sleep-wake disorder: a case report. ( Guichard, K; Micoulaud-Franchi, JA; Philip, P; Taillard, J, 2021)
"Insomnia and circadian rhythm sleep disorders affect large proportions of the population and have pronounced effects on quality of life and daytime performance."1.51Clinical Sleep-Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders. ( Nissen, C; Riemann, D; Spiegelhalder, K, 2019)
"Subjective and objective sleepiness and sleep-related and hazardous driving events significantly increased following night shift compared with preshift."1.51Sleepiness and driving events in shift workers: the impact of circadian and homeostatic factors. ( Anderson, C; Collins, A; Ganesan, S; Howard, ME; Lockley, SW; Magee, M; Mulhall, MD; Rajaratnam, SMW; Sletten, TL; Stone, JE, 2019)
"The present results suggest that sleep fragmentation and any resultant cognitive deficits are likely not confounded by corresponding deficits in circadian rhythms."1.46Young children with Down syndrome show normal development of circadian rhythms, but poor sleep efficiency: a cross-sectional study across the first 60 months of life. ( Anand, P; Clark, C; Demara, BI; Edgin, JO; Fernandez, F; Nyhuis, CC; Ruby, NF; Spanò, G, 2017)
"Treatment with melatonin up to 14 mg at bedtime was initiated with complete realignment of the sleep-wake rhythm (tau 23."1.46Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst. ( Antelmi, E; Ferri, L; Filardi, M; Moresco, M; Pierangeli, G; Pizza, F; Plazzi, G; Toni, F; Vandi, S; Zucchelli, M, 2017)
"Patients with insomnia and healthy control participants completed a sleep log for 7 days."1.46Circadian Phase and Phase Angle Disorders in Primary Insomnia. ( Bremer, E; Brogna, LA; Burke, LM; Epstein, LJ; Flynn-Evans, EE; Gehrman, P; Kirsch, D; Lockley, SW; Miller, B; Murray, JM; Rajaratnam, SMW; Shekleton, JA, 2017)
"Melatonin levels were significantly suppressed by white light only."1.43Light at Night and Measures of Alertness and Performance: Implications for Shift Workers. ( Figueiro, MG; Plitnick, B; Sahin, L; Wood, B, 2016)
"Williams-Beuren syndrome (WBS), a neurodevelopmental disorder caused by a microdeletion on chromosomic region 7q11."1.43Correlations between behavior, memory, sleep-wake and melatonin in Williams-Beuren syndrome. ( Campos, LM; Giacheti, CM; Pinato, L; Rossi, NF; Santoro, SD, 2016)
"To characterize and compare insomnia symptoms within two common phenotypes of Shift Work Disorder."1.42Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder. ( Belcher, R; Drake, CL; Gumenyuk, V; Roth, T, 2015)
"Among shift work disorder patients, insomnia is linked to functional and cognitive impairments."1.42Insomnia in shift work disorder relates to occupational and neurophysiological impairment. ( Belcher, R; Gumenyuk, V; Roth, T, 2015)
"The melatonin level was higher in the morning for both day shifts (p = 0."1.42Sleep interruption associated with house staff work schedules alters circadian gene expression. ( Crabtree, BF; Fang, MZ; Kelly-McNeil, K; Kipen, H; Lew, JP; Ohman-Strickland, P; Zarbl, H, 2015)
"Finally, acute sleep deprivation impaired behavioral performance and the P3a ERP in both groups."1.40Sleep loss, circadian mismatch, and abnormalities in reorienting of attention in night workers with shift work disorder. ( Drake, CL; Gumenyuk, V; Howard, R; Korzyukov, O; Roth, T, 2014)
"Melatonin is a hormone with well-known chronobiotic and hypnotic effects."1.40Chronobiology, cognitive function and depressive symptoms in surgical patients. ( Hansen, MV, 2014)
"Treatment with melatonin prevented premature aging and tumorigenesis in rodents."1.38Light-at-night-induced circadian disruption, cancer and aging. ( Anisimov, VN; Panchenko, AV; Popovich, IG; Vinogradova, IA; Zabezhinski, MA, 2012)
"Melatonin concentration was measured with a radioimmunoassay and DLMO was defined as the time at which the melatonin concentration in saliva reaches 4 pg/mL."1.37Evaluation of salivary melatonin measurements for Dim Light Melatonin Onset calculations in patients with possible sleep-wake rhythm disorders. ( Endenburg, SC; Gunnewiek, JM; Keijzer, H; Looman, CW; Peeters, T; Smits, MG, 2011)
"Before treatment, the patient had mild hypersomnia with long sleep time (704 min), ultradian sleep-wake rhythm (sleep occurred every 11."1.36Sleep and rhythm consequences of a genetically induced loss of serotonin. ( Arnulf, I; Boniol, C; Clot, F; Decaix, C; Leu-Semenescu, S; Levy, R; Moussa, F; Roze, E; Touitou, Y; Vidailhet, M, 2010)
"Disturbed sleep and/or hypersomnia are direct consequences of shift work and therefore described as shift work disorder."1.36[Burden and health effects of shift work]. ( Heitmann, J, 2010)
"Tasimelteon has been claimed to be useful in the treatment of depression, and preclinical evidence in this respect is to be confirmed in a phase II clinical trial, which was ready to be initiated at the time of publication."1.35Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. ( Hardeland, R, 2009)
"Treatment with melatonin (5 mg, 2 h before bedtime) did not improve his condition."1.33Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder? ( Dagan, Y; Doljansky, JT; Kannety, H, 2005)
"Melatonin and GH were measured every 10 min over 24 h."1.32The 24-h growth hormone rhythm in men: sleep and circadian influences questioned. ( Brandenberger, G; Weibel, L, 2004)
"Melatonin suppression was not significantly different with upper or middle field illumination."1.31Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteers. ( Elliott, JA; Kripke, DF; Smith, JS; Youngstedt, SD, 2002)
"Melatonin treatment improved all scales except the scale "role due to emotional problems."1.31Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. ( Coenen, AM; Kerkhof, GA; Laurant, MW; Nagtegaal, JE; Smits, MG; van der Meer, YG, 2000)
"Melatonin treatment increased nighttime sleep from 5."1.31Melatonin improves sleep-wake patterns in psychomotor retarded children. ( Etzioni, A; Lavie, P; Peled, N; Pillar, G; Ravid, S; Shahar, E, 2000)
"Melatonin is a well-tolerated, safe, relatively inexpensive, and effective drug, with minimal side effects, for the treatment of severe circadian rhythm sleep disorder in handicapped children."1.31Melatonin for the treatment of handicapped children with severe sleep disorders. ( Jan, MM, 2000)
"Melatonin (3 mg) was commenced following chronotherapy and this improved their sleep-wake rhythm."1.31Therapeutic progress of two sibling cases exhibiting sleep-wake rhythm disorder. ( Maeda, H; Mukai, M; Sakamoto, T; Takaishi, J; Takeuchi, N; Uchimura, N; Waseda, Y, 2000)
"The subjects were 46 patients with circadian rhythm sleep disorders: 30 Delayed Sleep Phase Syndrome (DSPS) and 16 non-24 h sleep-wake syndrome (non-24)."1.31Melatonin treatment for circadian rhythm sleep disorders. ( Hayakawa, T; Kamei, Y; Kim, K; Kudo, Y; Okawa, M; Shibui, K; Uchiyama, M; Urata, J, 2000)
"Advanced sleep phase syndrome is characterized by the complaint of persistent early evening sleep onset and early morning awakening."1.31Familial advanced sleep phase syndrome. ( Chang, AM; Dubocovich, ML; Reid, KJ; Takahashi, JS; Turek, FW; Zee, PC, 2001)
"Seventy-two elders with complaints of insomnia or depression, and 30 young, healthy adults were assessed for 5-7 days at home."1.31Circadian abnormalities in older adults. ( Elliott, JA; Klauber, MR; Kripke, DF; Youngstedt, SD, 2001)
"Melatonin is an indole hormone that is produced by the pineal gland, mainly at night, with a peak around 3."1.31[Melatonin and circadian rhythm]. ( Borson-Chazot, F; Brun, J; Claustrat, B, 2001)
"Melatonin is a promising treatment alternative for serious sleep problems in blind children."1.31[Melatonin treatment of a blind child with serious sleep disorders]. ( Loge, JH; Ramstad, K, 2002)

Research

Studies (358)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (0.84)18.2507
2000's147 (41.06)29.6817
2010's150 (41.90)24.3611
2020's58 (16.20)2.80

Authors

AuthorsStudies
Sun, SY1
Chen, GH1
Gibson, M1
Boivin, DB5
Boudreau, P2
Kosmadopoulos, A1
Qian, J1
Morris, CJ1
Phillips, AJK5
Li, P1
Rahman, SA6
Wang, W3
Hu, K2
Arendt, J9
Czeisler, CA14
Scheer, FAJL2
Duffy, JF9
Ronda, JM2
Wang, J2
Di, H1
Kim, JH2
Elkhadem, AR1
Cyr, M1
Artenie, DZ1
Al Bikaii, A1
Borsook, D1
Olson, JA1
Sun, Y1
Feng, W1
Chen, J1
Liu, M1
Shi, X1
Zou, L1
Xu, T1
Yang, G1
Shimura, A1
Kanno, T1
Inoue, T1
Carriedo-Diez, B1
Tosoratto-Venturi, JL1
Cantón-Manzano, C1
Wanden-Berghe, C1
Sanz-Valero, J1
Meyer, N1
Harvey, AG1
Lockley, SW16
Dijk, DJ11
Burgess, HJ14
Emens, JS7
van Andel, E2
Bijlenga, D3
Vogel, SWN2
Beekman, ATF2
Kooij, JJS2
Hartstein, LE3
Diniz Behn, C4
Wright, KP6
Akacem, LD3
Stowe, SR3
LeBourgeois, MK3
Glacet, R2
Reynaud, E2
Robin-Choteau, L2
Reix, N2
Hugueny, L2
Ruppert, E2
Geoffroy, PA3
Kilic-Huck, Ü3
Comtet, H2
Bourgin, P2
Huang, X2
Huang, Y1
Hu, B1
Tuft, C1
Matar, E1
Menczel Schrire, Z1
Grunstein, RR5
Yee, BJ1
Hoyos, CM1
Swanson, LM1
Raglan, GB1
Bazin, B1
Benzaquen, H1
Maruani, J1
Romier, A1
Lejoyeux, M1
D'ortho, MP1
Frija-Masson, J1
Hida, A2
Iida, A1
Ukai, M1
Kadotani, H1
Uchiyama, M6
Ebisawa, T2
Inoue, Y4
Kitamura, S2
Mishima, K4
Pundir, M2
De Rosa, MC1
Lobanova, L2
Abdulmawjood, S1
Chen, X3
Papagerakis, S2
Papagerakis, P2
Atan, YS1
Subaşı, M1
Güzel Özdemir, P1
Batur, M1
Ziegler, KA1
Ahles, A1
Dueck, A1
Esfandyari, D1
Pichler, P1
Weber, K1
Kotschi, S1
Bartelt, A1
Sinicina, I1
Graw, M1
Leonhardt, H1
Weckbach, LT1
Massberg, S1
Schifferer, M1
Simons, M1
Hoeher, L1
Luo, J1
Ertürk, A1
Schiattarella, GG1
Sassi, Y1
Misgeld, T1
Engelhardt, S1
Davis, H1
Attwell, D1
Lack, LC7
Micic, G5
Lovato, N7
Moraes, MM1
Marques, AL1
Borges, L1
Hatanaka, E1
Heller, D1
Núñez-Espinosa, C1
Gonçalves, DAP1
Soares, DD1
Wanner, SP1
Mendes, TT1
Arantes, RME1
Typaldos, M1
Sockrider, M1
Moderie, C3
Van der Maren, S3
Paquet, J2
Dumont, M4
Mocayar Marón, FJ1
Ferder, L1
Reiter, RJ3
Manucha, W1
Reutrakul, S1
Crowley, SJ6
Park, JC1
Chau, FY1
Priyadarshini, M1
Hanlon, EC1
Danielson, KK1
Gerber, BS1
Baynard, T1
Yeh, JJ1
McAnany, JJ1
Butler, MP1
Thosar, SS1
Smales, C1
DeYoung, PN1
Wu, H1
Hussain, MV1
Morimoto, M1
Shea, SA2
Watson, LA2
McGlashan, EM2
Hosken, IT2
Anderson, C3
Cain, SW2
Sciarra, F1
Franceschini, E1
Campolo, F1
Gianfrilli, D1
Pallotti, F1
Paoli, D1
Isidori, AM1
Venneri, MA1
Coles, ME1
Schubert, J1
Stewart, E1
Sharkey, KM6
Deak, M1
Ferguson, SA3
Lack, L5
Ballester, P1
Richdale, AL1
Baker, EK1
Peiró, AM1
Kimura, S1
Toyoura, M1
Toyota, Y1
Takaoka, Y1
El-Benhawy, SA1
El-Tahan, RA1
Nakhla, SF1
Sholtes, D1
Kravitz, HM1
Deka, A1
Westrick, J1
Fogg, LF6
Gottlieb, M1
Feder, MA1
Baroni, A2
Wang, F2
Xie, N1
Wu, Y1
Zhang, Q1
Zhu, Y2
Dai, M1
Zhou, J1
Pan, J1
Tang, M1
Cheng, Q1
Shi, B1
Guo, Q1
Li, X1
Xie, L1
Wang, B1
Yang, D1
Weng, Q1
Guo, L1
Ye, J1
Pan, M1
Zhang, S1
Zhou, H1
Zhen, C1
Liu, P1
Ning, K1
Brackenridge, L1
Hardiman, PJ1
Qu, F1
da Silveira Cruz-Machado, S1
Guissoni Campos, LM1
Fadini, CC1
Anderson, G1
Markus, RP1
Pinato, L2
Quera-Salva, MA3
Vecchierini, MF1
Abbott, SM2
Epstein, LJ2
Gamble, KL2
Hasler, BP4
Kristo, DA1
Malkani, RG1
Thomas, SJ1
Wyatt, JK7
Zee, PC14
Klerman, EB3
Martin, JS1
Laberge, L1
Sasseville, A1
Bérubé, M1
Alain, S1
Lavoie, J1
Houle, J1
Hébert, M1
Nishimon, S1
Nishino, N1
Nishino, S2
Guichard, K1
Micoulaud-Franchi, JA1
Philip, P1
Taillard, J1
Uddin, MS1
Sumsuzzman, DM1
Jeandet, P1
Behl, T1
Rauf, A1
Amran, MS1
Ashraf, GM1
Cheng, DCY1
Ganner, JL1
Gordon, CJ1
Phillips, CL1
Comas, M1
Zhao, S1
Hou, J1
Huang, L1
Xu, J1
He, M1
Shen, O1
Zhang, J1
Gehrman, PR1
Anafi, RC1
Grant, LK1
St Hilaire, MA3
Brainard, GC2
Cogswell, D1
Bisesi, P1
Markwald, RR1
Cruickshank-Quinn, C1
Quinn, K1
McHill, A1
Melanson, EL1
Reisdorph, N1
Depner, CM1
Brotman, DJ1
Lin, AL1
Lewy, AJ4
Saeed, Y1
Murray, JM3
Sletten, TL6
Magee, M5
Gordon, C2
Bartlett, DJ3
Kennaway, DJ5
Rajaratnam, SM3
Fernandez, F1
Nyhuis, CC1
Anand, P1
Demara, BI1
Ruby, NF1
Spanò, G1
Clark, C1
Edgin, JO1
Clerx, WM1
O'Brien, CS1
Sano, A1
Barger, LK1
Picard, RW1
Hunter, CM1
Figueiro, MG5
Ftouni, S2
Nicholas, CL2
Ferguson, S2
O'Brien, D1
Rajaratnam, SMW6
Auld, F1
Maschauer, EL1
Morrison, I1
Skene, DJ6
Riha, RL2
Spiegelhalder, K1
Nissen, C1
Riemann, D2
Burman, D1
Ferri, L1
Filardi, M1
Moresco, M1
Pizza, F1
Vandi, S1
Antelmi, E1
Toni, F1
Zucchelli, M1
Pierangeli, G1
Plazzi, G1
Flynn-Evans, EE1
Shekleton, JA1
Miller, B1
Kirsch, D1
Brogna, LA1
Burke, LM1
Bremer, E1
Gehrman, P1
Solaiman, SS1
Agrawal, R1
Duclos, C1
Daneault, V1
Keijzer, H3
Snitselaar, MA1
Smits, MG7
Spruyt, K1
Ehrhart, F1
Curfs, LM2
Hartley, S1
Dauvilliers, Y1
Ba-Ali, S1
Brøndsted, AE1
Andersen, HU1
Sander, B1
Jennum, PJ1
Lund-Andersen, H1
Resuehr, D1
Wu, G1
Johnson, RL1
Young, ME1
Hogenesch, JB1
Ghaziuddin, N1
Shamseddeen, W1
Bertram, H1
McInnis, M1
Wilcox, HC1
Mitchell, PB1
Fullerton, JM1
Roberts, GMP1
Glowinski, AL1
Kamali, M1
Stapp, E1
Hulvershorn, LA1
Nurnberger, J1
Armitage, R1
Ganesan, S2
Stone, JE2
Mulhall, MD2
Collins, A2
Howard, ME2
Simon, SL1
McWhirter, L1
Bubar, KM1
Kaar, JL1
Pyle, L1
Rahat, H1
Garcia-Reyes, Y1
Carreau, AM1
Nadeau, KJ1
Cree-Green, M1
Haraguchi, A1
Komada, Y2
Shibata, S2
Kuppili, PP1
Nebhinani, N1
Gupta, T1
Suthar, N1
Bei, B1
Culnan, E1
McCullough, LM1
Russcher, M3
Koch, BC4
Nagtegaal, JE5
van Ittersum, FJ1
Pasker-de Jong, PC1
Hagen, EC2
van Dorp, WT1
Gabreëls, B1
Wildbergh, TX1
van der Westerlaken, MM3
Gaillard, CA3
Ter Wee, PM3
White, RD1
Khan, SA1
George, R1
Charles, BG1
Taylor, PJ1
Heussler, HS1
Cooper, DM1
McGuire, TM1
Pache, D2
Norris, RL1
Montagnese, S1
De Pittà, C1
De Rui, M1
Corrias, M1
Turco, M1
Merkel, C1
Amodio, P1
Costa, R1
Gatta, A1
Shapiro, CM4
Ainlay, H1
Kazmi, S1
Brown, TJ1
Casper, RF3
de Bruyn, A1
Wright, H2
Gradisar, M4
Kovacic, P1
Somanathan, R1
Van Someren, EJ6
Gruber, R1
Bron, TI1
Kruithof, IF1
Spanbroek, EC1
Kooij, JJ1
Rondanelli, M1
Faliva, MA1
Perna, S1
Antoniello, N1
Wilhelmsen-Langeland, A2
Saxvig, IW2
Pallesen, S4
Nordhus, IH2
Vedaa, Ø1
Lundervold, AJ1
Bjorvatn, B6
Biggs, SN1
Armstrong, SM1
van de Werken, M2
Booij, SH1
van der Zwan, JE1
Simons, MJ1
Gordijn, MC2
Beersma, DG2
Morrissette, DA1
O'Neill, B1
Gardani, M1
Findlay, G1
Whyte, T1
Cullen, T1
Rovers, J1
Smits, M2
Freedom, T1
Gonzalez, R1
Kocher, L1
Lornage, J1
Claustrat, B2
Gumenyuk, V5
Howard, R2
Roth, T8
Korzyukov, O1
Drake, CL4
Gladanac, B1
Rahman, S1
Liira, J3
Verbeek, JH2
Costa, G2
Driscoll, TR2
Sallinen, M2
Isotalo, LK2
Ruotsalainen, JH2
Nesbitt, AD1
Hansen, MV1
Rana, S1
Shahid, A1
Ullah, H1
Mahmood, S1
Vinogradova, IA2
Iliukha, VA1
Khizhkin, EA1
Uzenbaeva, LB1
Il'ina, TN1
Bukalev, AV1
Goranskiĭ, AI1
Matveeva, IuP1
Iunash, VD1
Lotosh, TA1
Belcher, R3
Fifel, K1
DeBoer, T1
Videnovic, A1
Breen, DP1
Barker, RA1
Cuesta, M1
Cermakian, N2
Nurmohamed, SA1
Bakker, SJ1
Levin, AM1
Sahin, L1
Wood, B1
Plitnick, B1
Verbeek, J1
Ruotsalainen, J1
Paul, MA1
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Brennan, R1
Lyons, CJ1
Szeinberg, A1
Bogdan, A1
Benoit, M1
Schwartz, JR1
Sajith, SG1
Clarke, D1
Fallone, G1
Laakso, ML1
Lindblom, N1
Leinonen, L1
Kaski, M1
Barion, A1
Edwards, B1
Dishon, L1
Wakatsuki, Y1
Kudo, T1
Carr, R1
Hamilton, D2
Weiss, MD2
Tai, J2
Rietveld, WJ2
Chaperon, CM1
Farr, LA1
LoChiano, E1
Morgenthaler, TI1
Lee-Chiong, T1
Alessi, C1
Friedman, L1
Aurora, RN1
Boehlecke, B1
Brown, T1
Chesson, AL1
Kapur, V1
Maganti, R1
Owens, J1
Pancer, J1
Swick, TJ1
Zak, R1
Sack, RL3
Auckley, D1
Vitiello, MV1
Zhdanova, IV2
Mitrzyk, BM1
Bramley, TJ1
Vollenweider, S1
Flammer, J1
Orgül, S1
Kräuchi, K1
Dowling, GA1
Burr, RL1
Hubbard, EM1
Luxenberg, JS1
Mastick, J1
Cooper, BA1
Bomben, MM1
Menna-Barreto, L1
Bootzin, RR1
Cousins, JC1
Fridel, K1
Wenk, GL1
Dodd, A1
Hare, DJ1
Arshad, P1
Kosti, O1
Benhaberou-Brun, D1
Lambert, C1
Goh, VH2
Tong, TY2
Lim, CL1
Low, EC1
Lee, LK2
Laurant, MW1
van der Meer, YG1
Coenen, AM1
Shibui, K3
Liu, X1
Hayakawa, T3
Takahashi, K2
Lechner, O1
Dietrich, H1
Oliveira dos Santos, A1
Wiegers, GJ1
Schwarz, S1
Harbutz, M1
Herold, M1
Wick, G1
Domzał, TM1
Kaca-Oryńska, M1
Zaleski, P1
Pillar, G1
Shahar, E1
Peled, N1
Ravid, S1
Lavie, P2
Etzioni, A1
Jan, MM1
Mukai, M1
Uchimura, N1
Takeuchi, N1
Waseda, Y1
Takaishi, J1
Sakamoto, T1
Maeda, H1
Urata, J1
Kim, K1
Kudo, Y1
Akaboshi, S1
Kubota, N1
Takeshita, K1
Hayashi, E1
Takahashi, JS1
Zisapel, N1
Rivkees, SA1
Roehrs, T1
Klauber, MR1
Bauer, VK1
Kendall, AR1
Pires, ML1
Laitinen, JT1
Porkka-Heiskanen, T1
Tagaya, H1
Alcalá, YC1
Khalsa, SB1
Conroy, DA1
Brun, J1
Borson-Chazot, F1
Quera Salva, MA1
Lainey, E1
Léger, D1
Santos, C1
Billiard, M2
Ondzé, B1
Espa, F1
Ming, LC1
Chakkar, B1
Besset, A1
Apter, N1
Partinen, M1
Bernert, RA1
Ramstad, K2
Loge, JH2

Clinical Trials (32)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sleep Length and Euploid Embryo Transfer Prospective Study[NCT06139757]150 participants (Anticipated)Observational2024-01-01Not yet recruiting
Prevalence of Epilepsy and Sleep Wake Disorders in Alzheimer Disease[NCT03617497]78 participants (Actual)Interventional2020-12-01Active, not recruiting
Piloting an Adaption of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)[NCT05965609]60 participants (Anticipated)Interventional2023-12-08Recruiting
Assessment of Hepatic Glucose and Fat Regulation in Overweight Adolescent Girls[NCT02157974]Phase 2/Phase 392 participants (Actual)Interventional2014-08-31Completed
Investigating the Relationship Between Circadian Phase and Insulin Resistance in Obese Adolescents[NCT02585830]25 participants (Actual)Observational2015-10-31Completed
Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment[NCT00834886]Phase 440 participants (Actual)Interventional2008-10-31Completed
Role of Endogenous Melatonin Level in Preoperative and Postoperative Anxiety in Bariatric Surgery Patients[NCT03109054]50 participants (Anticipated)Observational2017-03-15Enrolling by invitation
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599]Phase 286 participants (Actual)Interventional2016-07-31Completed
Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.[NCT03107702]35 participants (Anticipated)Observational2017-03-29Enrolling by invitation
[NCT01487252]73 participants (Actual)Interventional2011-12-31Completed
Circadian Misalignment as a Disease Risk Factor in Inflammatory Bowel Disease[NCT04637399]52 participants (Actual)Observational2016-11-22Completed
Sleep Thermography for Diagnosis of Obstructive Sleep Apnea (OSA)[NCT04206449]198 participants (Actual)Interventional2018-09-10Completed
Regulating Mood and Suicidal Ideation With Morning Light Exposure Treatment[NCT05616819]480 participants (Anticipated)Interventional2023-03-01Not yet recruiting
Effects of Procedure Started in the Morning and Afternoon on Early Postoperative Sleep Function and Postoperative Recovery in Patients Under General Anesthesia[NCT04103528]62 participants (Actual)Interventional2018-10-09Completed
The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms[NCT03758768]34 participants (Actual)Interventional2018-09-25Completed
Does CBT Improve the Effect of Light Therapy in Delayed Sleep Phase Syndrome Compared to Only Light Therapy - Short and Long Term Follow up[NCT01419938]57 participants (Actual)Interventional2011-08-31Completed
The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients[NCT00404456]Phase 340 participants (Anticipated)Interventional2005-04-30Completed
A Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Agomelatine in the Prevention of Poststroke Depression[NCT05426304]Phase 4420 participants (Anticipated)Interventional2022-10-01Not yet recruiting
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172]Phase 260 participants (Actual)Interventional2014-12-31Completed
Prevention of Delirium in Inpatients Utilizing Melatonin[NCT02654314]Phase 3277 participants (Actual)Interventional2016-07-31Terminated (stopped due to Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.)
Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950]104 participants (Anticipated)Interventional2017-06-26Recruiting
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia[NCT03075657]Phase 4120 participants (Actual)Interventional2017-05-01Completed
Effects of Shift Work on Health: Assessment of Sleep Quality, Motor Control and Cardiovascular Risk.[NCT03453398]71 participants (Actual)Interventional2018-01-23Completed
Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309]Phase 325 participants (Actual)Interventional2016-07-31Completed
Sleep and Circadian Regulation in Diabetic Retinopathy: The Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation[NCT04547439]Phase 236 participants (Anticipated)Interventional2021-02-03Recruiting
Effects of Bright Light Treatment on Daytime Sleepiness and Nocturnal Sleep in Patients With Parkinson's Disease[NCT01338649]27 participants (Actual)Interventional2007-11-30Completed
Restoration of Sleep in Heart Failure Patients[NCT00869869]Phase 20 participants (Actual)Interventional2009-03-31Withdrawn (stopped due to No subjects were enrolled in this study. Funding ran out.)
Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars[NCT01169233]25 participants (Actual)Interventional2008-08-31Completed
A Placebo-controlled, Double -Blind Randomised Trial of Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence[NCT03897062]Phase 222 participants (Actual)Interventional2019-08-26Terminated (stopped due to Recruitment problems during covid lockdowns resulted in Merck ceasing supply of suvorexant/placebo)
Characterization of Endogenous Melatonin Profiles in Children With Autism Spectrum Disorder.[NCT00691080]58 participants (Actual)Observational2007-09-30Completed
Melatonin Entrainment of Elderly Blind Free-runners[NCT00692094]12 participants (Actual)Interventional2004-08-31Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.)
Effects of Blocking Blue Light at Night on Patient Outcomes After Elective CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH[NCT04578249]80 participants (Anticipated)Interventional2021-09-20Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dim Light Melatonin Onset and Offset

~1mL saliva was collected at 30- to 60- minute intervals in dim light (<5 lux in the angle of gaze, approximately the light level of candlelight or civil twilight) from approximately 5pm until noon the next day. Dim light melatonin onset (DLMOn) was defined as the linear interpolated clock time at which evening salivary melatonin concentrations increased and remained above a threshold of 3pg/mL. Melatonin offset (DLMOff) was the linear interpolated clock time at which salivary melatonin concentrations fell below this threshold. Later DLMOn and DLMOff are indicative of a later circadian rhythm. (NCT02585830)
Timeframe: 1 day

Interventiondecimal hours (Mean)
Dim Light Melatonin OnsetDim Light Melatonin Offset
Observation21.338.32

Insulin Sensitivity

After an overnight fast, participants completed an oral glucose tolerance test (OGTT) in the morning. Participants consumed a 75g dextrose drink and serum for glucose and insulin concentrations were collected at baseline and every 30 minutes for 3 hours. The homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as [fasting insulin (μU/ml) x fasting glucose (mmol/l)] / 22.5); lower HOMA-IR indicates better insulin sensitivity. The Matsuda Index was calculated as √10,000 / [[fasting insulin (μU/ml) x fasting glucose (mmol/l)] x [mean OSTT insulin (μU/ml) x mean OSTT glucose (mmol/l)]]; high Matsuda Index indicates better insulin sensitivity. (NCT02585830)
Timeframe: 3 hours

Interventionunits on a scale (Mean)
Homeostatic Model Assessment (HOMA-IR)Matsuda Index
Observation2.94.93

To Investigate the Efficacy on Rise Time of Bright Light Therapy and Melatonin Treatment Using a 4 Armed Placebo Controlled Design. Main Outcome Measures: Sleep Log, Actigraphy and Psychological Tests.

"Sleep diary, rise time (when participants rise from bed in the morning, self-report) before and after a randomized controlled 4 armed treatment study including a follow-up 3 months later.~Midnight is 0000; in the outcome measure table the value is given in minutes after midnight.~i.e. 530 equals 08:50 in the morning." (NCT00834886)
Timeframe: 1 day after two-week treatment ends

InterventionMinutes (Mean)
Combination530
Melatonin506
Bright Light520
Placebo543

To Investigate the Efficacy on Sleep Onsel Latency of Bright Light Therapy and Melatonin Treatment Using a 4 Armed Placebo Controlled Design. Main Outcome Measures: Sleep Log, Actigraphy and Psychological Tests.

Actigraphy, sleep onset latency (SOL). An actigraph is a wrist-worn movement sensor that objectively record motor activity. Participants used an event button to mark bed time and rise time. The actiwatch is waterproof and participants were instructed not to take it off at any time during the data collection peroid. (NCT00834886)
Timeframe: 1 day after 2-week treatment ended

InterventionMinutes (Mean)
Combination11
Melatonin21
Bright Light15
Placebo24

To Investigate the Efficacy on Subjective Sleepiness of Bright Light Therapy and Melatonin Treatment Using a 4 Armed Placebo Controlled Design. Main Outcome Measures: Sleep Log, Actigraphy and Psychological Tests.

"Subjective sleepiness; Karolinska sleepiness scale (KSS). The KSS is a scale in which the subjects rate their concurrent sleepiness level. The scale is verbally anchored with steps ranging from 1 (very alert) to 9 (very sleepy, fighting sleep, effort to stay awake)." (NCT00834886)
Timeframe: 1 day after 2-week treatment ended

Interventionunits on a scale (Mean)
Combination6.0
Melatonin5.9
Bright Light6.3
Placebo6.5

Postoperative Hospital Stay

Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days

Interventiondays (Median)
Morphine7
Levobupivacaine7

Changes in C-reactive Protein (CRP) Levels

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

,
Interventionmg/L (Median)
Before surgery24 h after surgery72 h after surgery120 h after surgery
Levobupivacaine57.898.19554.6
Morphine57.2106.2118.566.9

Changes in Cognitive Function

"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery

,
Interventionscore on a scale (Median)
Before surgery24 h after surgery48 h after surgery72 h after surgery96 h after surgery120 h after surgery
Levobupivacaine222221212122
Morphine212020202020

Changes in Fibrinogen Concentrations in Peripheral Blood

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

,
Interventiong/L (Median)
Before surgery24 h after surgery72 h after surgery120 h after surgery
Levobupivacaine4.54.75.25
Morphine5.55.35.75.4

Changes in Pain Intensity

"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge

,
Interventionscore on a scale (Median)
3,6,9,12,15,18,21 and 24h after surgery27,30,33,36,39,42,45 and 48h after surgery51,54,57,60,63,66,69 and 72h after surgery4. postoperative day (every 8 hours)5. postoperative day (every 8 hours)6. postoperative day (every 8 hours)Day of discharge
Levobupivacaine0.60.50.50.3000
Morphine1.41.51.41.41.41.31

Interleukin-6 Concentration in Peripheral Blood.

Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery

,
Interventionpg/ml (Median)
Before surgery24h after surgery72h after surgery
Levobupivacaine26.697.730.5
Morphine27.210450

Days Utilizing Restraints

Days utilizing restraints is defined as the number of days restraints were applied because of delirium in the first 14 days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Interventiondays (Median)
Melatonin0
Cellulose Microcrystylline0

Delirium

Delirium is defined by the Short Form Confusion Assessment Method (CAM). There must be inattention and either an acute or fluctuating course plus either disorganized thinking or an altered level of consciousness to be diagnosed with delirium. Presented is a count of individuals with reported delirium during hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

InterventionParticipants (Count of Participants)
Melatonin2
Cellulose Microcrystylline8

Length of Hospital Stay

Length of stay is defined as the total time hospitalized for the acute illness (in days). (NCT02654314)
Timeframe: from day of admission to completion of acute care, not to exceed 30 days

Interventiondays (Mean)
Melatonin4.58
Cellulose Microcrystylline4.71

Number of Delirium Anti-psychotic Drug Doses Utilized for Delirium During the First 14 Days of Hospitalization.

Number of delirium anti-psychotic drug doses given for symptoms of delirium. Presented are the number of doses per days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days

Interventionnumber of doses per days of hospitalizat (Median)
Melatonin0
Cellulose Microcrystylline0

Change in the Epworth Sleepiness Scale (ESS) Scores Comparing the Bright Light Exposure With Dim-red Light Exposure.

ESS score range is 0-24; lower ESS scores indicate less daytime sleepiness; higher ESS scores indicate more severe sleepiness ESS will be taken and compared at screening and week 4 visits between the bright light exposure and dim-red light exposure groups. (NCT01338649)
Timeframe: baseline and 4 weeks

Interventionscore (Mean)
Bright White4.46
Dim Red Light1.77

Reviews

126 reviews available for melatonin and Sleep Disorders, Circadian Rhythm

ArticleYear
Treatment of Circadian Rhythm Sleep-Wake Disorders.
    Current neuropharmacology, 2022, Volume: 20, Issue:6

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiation and

2022
A systematic review of the relationship between night shift work and oxidative stress.
    Chronobiology international, 2022, Volume: 39, Issue:2

    Topics: Circadian Rhythm; Humans; Melatonin; Oxidative Stress; Reactive Oxygen Species; Shift Work Schedule;

2022
Disturbance of the Circadian System in Shift Work and Its Health Impact.
    Journal of biological rhythms, 2022, Volume: 37, Issue:1

    Topics: Circadian Rhythm; Humans; Leukocytes, Mononuclear; Melatonin; Shift Work Schedule; Sleep; Sleep Diso

2022
Circadian Rhythm Sleep-Wake Disorders in Older Adults.
    Sleep medicine clinics, 2022, Volume: 17, Issue:2

    Topics: Aged; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Diso

2022
The effect of evening light on circadian-related outcomes: A systematic review.
    Sleep medicine reviews, 2022, Volume: 64

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Work Schedule

2022
The Effects of the Exogenous Melatonin on Shift Work Sleep Disorder in Health Personnel: A Systematic Review.
    International journal of environmental research and public health, 2022, 08-17, Volume: 19, Issue:16

    Topics: Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Sleep; Sleep Disorder

2022
Circadian rhythms and disorders of the timing of sleep.
    Lancet (London, England), 2022, 09-24, Volume: 400, Issue:10357

    Topics: Biological Factors; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; S

2022
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances.
    Sleep medicine clinics, 2022, Volume: 17, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Receptors, Melatonin; Sleep; Sleep Disorders, Circadian Rhythm

2022
Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults.
    Clinical interventions in aging, 2023, Volume: 18

    Topics: Aged; Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Sleep; Sleep Disorders, Circadia

2023
Circadian Interventions as Adjunctive Therapies to Cognitive-Behavioral Therapy for Insomnia.
    Sleep medicine clinics, 2023, Volume: 18, Issue:1

    Topics: Circadian Rhythm; Cognitive Behavioral Therapy; Humans; Melatonin; Sleep; Sleep Disorders, Circadian

2023
Circadian aspects in the aetiology and pathophysiology of insomnia.
    Journal of sleep research, 2023, Volume: 32, Issue:6

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiation and

2023
Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin.
    The Journal of steroid biochemistry and molecular biology, 2020, Volume: 199

    Topics: Animals; Apoptosis; Humans; Melatonin; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Reni

2020
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances.
    Sleep medicine clinics, 2020, Volume: 15, Issue:2

    Topics: Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Sleep; Sleep Disorders, Circadian Rhyt

2020
Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility.
    International journal of molecular sciences, 2020, May-30, Volume: 21, Issue:11

    Topics: Androgens; Animals; Body Temperature; Circadian Clocks; Circadian Rhythm; Estrogens; Female; Glucoco

2020
Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review.
    Journal of biological rhythms, 2020, Volume: 35, Issue:5

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm

2020
Sleep in autism: A biomolecular approach to aetiology and treatment.
    Sleep medicine reviews, 2020, Volume: 54

    Topics: Autistic Disorder; Brain; Central Nervous System Depressants; Comorbidity; gamma-Aminobutyric Acid;

2020
Optimising sleep and performance during night float: A systematic review of evidence and implications for graduate medical education trainees.
    Journal of sleep research, 2021, Volume: 30, Issue:4

    Topics: Adaptation, Physiological; Attention; Caffeine; Education, Medical, Graduate; Energy Drinks; Fatigue

2021
Just Let Me Sleep in: Identifying and Treating Delayed Sleep Phase Disorder in Adolescents.
    Child and adolescent psychiatric clinics of North America, 2021, Volume: 30, Issue:1

    Topics: Adolescent; Humans; Melatonin; Prevalence; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Initiatio

2021
Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.
    Neurochemical research, 2021, Volume: 46, Issue:7

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Circadian Rhythm; Gastrointestin

2021
The efficacy of combined bright light and melatonin therapies on sleep and circadian outcomes: A systematic review.
    Sleep medicine reviews, 2021, Volume: 58

    Topics: Aged; Circadian Rhythm; Humans; Light; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wa

2021
Circadian Disruption Associated with Alzheimer's Disease.
    Current neurology and neuroscience reports, 2017, Volume: 17, Issue:4

    Topics: Alzheimer Disease; Amyloidogenic Proteins; Animals; Circadian Rhythm; Humans; Melatonin; Phototherap

2017
Measuring Light at Night and Melatonin Levels in Shift Workers: A Review of the Literature.
    Biological research for nursing, 2017, Volume: 19, Issue:4

    Topics: Adult; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Middle Aged; Neoplasms; Photoperiod

2017
Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.
    Sleep medicine reviews, 2017, Volume: 34

    Topics: Humans; Melatonin; Randomized Controlled Trials as Topic; Sleep Disorders, Circadian Rhythm; Sleep W

2017
Sleep Disorders: Circadian Rhythm Sleep-Wake Disorders.
    FP essentials, 2017, Volume: 460

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Hygiene; Wakefu

2017
Circadian Rhythm Sleep-Wake Disorders in Older Adults.
    Sleep medicine clinics, 2018, Volume: 13, Issue:1

    Topics: Aged; Central Nervous System Depressants; Circadian Clocks; Circadian Rhythm; Humans; Jet Lag Syndro

2018
Precision medicine in circadian rhythm sleep-wake disorders: current state and future perspectives.
    Personalized medicine, 2017, Volume: 14, Issue:2

    Topics: Circadian Rhythm; Humans; Melatonin; Polysomnography; Precision Medicine; Sleep; Sleep Disorders, Ci

2017
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances.
    Sleep medicine clinics, 2018, Volume: 13, Issue:2

    Topics: Humans; Hypnotics and Sedatives; Melatonin; Receptors, Melatonin; Sleep Disorders, Circadian Rhythm

2018
Circadian Rhythm Disturbances in the Blind.
    Current neurology and neuroscience reports, 2018, 08-06, Volume: 18, Issue:10

    Topics: Blindness; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake

2018
The use and misuse of exogenous melatonin in the treatment of sleep disorders.
    Current opinion in pulmonary medicine, 2018, Volume: 24, Issue:6

    Topics: Central Nervous System Depressants; Humans; Melatonin; Parasomnias; Sleep; Sleep Disorders, Circadia

2018
Circadian Rhythm Sleep-Wake Phase Disorders.
    Neurologic clinics, 2019, Volume: 37, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Sleep Disorders, Circadian Rhythm

2019
Health consequences of shift work and implications for structural design.
    Journal of perinatology : official journal of the California Perinatal Association, 2013, Volume: 33 Suppl 1

    Topics: Animals; Breast Neoplasms; Circadian Rhythm; Hospital Design and Construction; Humans; Intensive Car

2013
Sleep-wake abnormalities in patients with cirrhosis.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:2

    Topics: Circadian Rhythm; Hepatic Encephalopathy; Homeostasis; Humans; Liver; Liver Cirrhosis; Melatonin; Sl

2014
Cell signaling, receptors, electrical effects and therapy in circadian rhythm.
    Journal of receptor and signal transduction research, 2013, Volume: 33, Issue:5

    Topics: Animals; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Electroconvulsive Therapy; Humans; Jet

2013
Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.
    Aging clinical and experimental research, 2013, Volume: 25, Issue:5

    Topics: Animals; Carcinogenesis; Humans; Melatonin; Mood Disorders; Neoplasms; Sleep Disorders, Circadian Rh

2013
Circadian rhythm disorders among adolescents: assessment and treatment options.
    The Medical journal of Australia, 2013, Oct-21, Volume: 199, Issue:8

    Topics: Adolescent; Anxiety Disorders; Australia; Comorbidity; Cross-Sectional Studies; Depressive Disorder;

2013
Twisting the night away: a review of the neurobiology, genetics, diagnosis, and treatment of shift work disorder.
    CNS spectrums, 2013, Volume: 18 Suppl 1

    Topics: Antidepressive Agents; Biological Clocks; Central Nervous System Stimulants; Circadian Rhythm; Human

2013
Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders.
    Sleep medicine reviews, 2014, Volume: 18, Issue:4

    Topics: Circadian Rhythm; Drug Administration Schedule; Humans; Light; Melatonin; Saliva; Sleep Disorders, C

2014
[Circadian rhythm sleep disorder].
    Nihon rinsho. Japanese journal of clinical medicine, 2013, Volume: 71, Issue:12

    Topics: Humans; Melatonin; Phototherapy; Receptors, Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Vit

2013
The relationship between bipolar disorder and biological rhythms.
    The Journal of clinical psychiatry, 2014, Volume: 75, Issue:4

    Topics: Bipolar Disorder; Chronobiology Disorders; Circadian Rhythm; Genetic Predisposition to Disease; Huma

2014
Spectral modulation of light wavelengths using optical filters: effect on melatonin secretion.
    Fertility and sterility, 2014, Volume: 102, Issue:2

    Topics: Animals; Circadian Clocks; Circadian Rhythm; Humans; Light; Melatonin; Photoperiod; Phototherapy; Sl

2014
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
    The Cochrane database of systematic reviews, 2014, Aug-12, Issue:8

    Topics: Azabicyclo Compounds; Benzhydryl Compounds; Caffeine; Humans; Hypnotics and Sedatives; Melatonin; Mo

2014
Out of synch with society: an update on delayed sleep phase disorder.
    Current opinion in pulmonary medicine, 2014, Volume: 20, Issue:6

    Topics: Benzofurans; Circadian Rhythm; Cyclopropanes; Environmental Exposure; Homeostasis; Humans; Light; Me

2014
Impacts of shift work on sleep and circadian rhythms.
    Pathologie-biologie, 2014, Volume: 62, Issue:5

    Topics: Accidents; Arousal; Automobile Driving; Cardiovascular Diseases; Circadian Rhythm; Circadian Rhythm

2014
Effect of Light and Melatonin and Other Melatonin Receptor Agonists on Human Circadian Physiology.
    Sleep medicine clinics, 2015, Volume: 10, Issue:4

    Topics: Central Nervous System Agents; Circadian Rhythm; Humans; Light; Melatonin; Phototherapy; Receptors,

2015
A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder.
    Attention deficit and hyperactivity disorders, 2017, Volume: 9, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Chronotherapy; Circadian Clocks; Humans; Melatonin; S

2017
The relationship between insomnia and body temperatures.
    Sleep medicine reviews, 2008, Volume: 12, Issue:4

    Topics: Arousal; Body Temperature Regulation; Circadian Rhythm; Homeostasis; Humans; Melatonin; Phototherapy

2008
The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders.
    Nature clinical practice. Neurology, 2008, Volume: 4, Issue:8

    Topics: Animals; Humans; Light; Melatonin; Phototherapy; Sleep Disorders, Circadian Rhythm

2008
The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders.
    Journal of pineal research, 2009, Volume: 46, Issue:1

    Topics: Electroencephalography; Humans; Melatonin; Pineal Gland; Sleep; Sleep Disorders, Circadian Rhythm; T

2009
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
A practical approach to circadian rhythm sleep disorders.
    Sleep medicine reviews, 2009, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged;

2009
Melatonin, sleep disturbance and cancer risk.
    Sleep medicine reviews, 2009, Volume: 13, Issue:4

    Topics: Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Circadian Rhythm; Dietary Fats; Female;

2009
Chromotherapy in the regulation of neurohormonal balance in human brain--complementary application in modern psychiatric treatment.
    Collegium antropologicum, 2008, Volume: 32 Suppl 2

    Topics: Color Therapy; Depressive Disorder; Humans; Melatonin; Seasonal Affective Disorder; Serotonin; Sleep

2008
[Depression and circadian rhythm].
    L'Encephale, 2009, Volume: 35 Suppl 2

    Topics: Biological Clocks; Circadian Rhythm; Depressive Disorder; Humans; Melatonin; Seasonal Affective Diso

2009
Melatonin and its agonists, circadian rhythms and psychiatry.
    African journal of psychiatry, 2009, Volume: 12, Issue:1

    Topics: Adult; Aged; Central Nervous System Depressants; Child; Circadian Rhythm; Humans; Melatonin; Mental

2009
[Circadian rhythm sleep disorders].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2009, Sep-24, Volume: 129, Issue:18

    Topics: Central Nervous System Depressants; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep Dis

2009
Managing the patient with shift-work disorder.
    The Journal of family practice, 2010, Volume: 59, Issue:1 Suppl

    Topics: Benzhydryl Compounds; Combined Modality Therapy; Diet; Environment; Exercise; Female; Humans; Life S

2010
Circadian rhythm sleep disorders.
    The Indian journal of medical research, 2010, Volume: 131

    Topics: Biological Clocks; Circadian Rhythm; Guidelines as Topic; Humans; Jet Lag Syndrome; Melatonin; Polys

2010
Impact of the novel antidepressant agomelatine on disturbed sleep-wake cycles in depressed patients.
    Human psychopharmacology, 2010, Volume: 25, Issue:3

    Topics: Acetamides; Animals; Antidepressive Agents; Depressive Disorder, Major; Humans; Melatonin; Randomize

2010
Investigational melatonin receptor agonists.
    Expert opinion on investigational drugs, 2010, Volume: 19, Issue:6

    Topics: Animals; Circadian Rhythm; Drugs, Investigational; Half-Life; Humans; Insulin; Melatonin; Receptors,

2010
Circadian rhythms and clock genes in psychotic disorders.
    The Israel journal of psychiatry and related sciences, 2010, Volume: 47, Issue:1

    Topics: Animals; Bipolar Disorder; Circadian Rhythm; CLOCK Proteins; Glycogen Synthase Kinase 3; Humans; Lit

2010
Melatonin: pharmacological aspects and clinical trends.
    The International journal of neuroscience, 2010, Volume: 120, Issue:9

    Topics: Animals; Antidepressive Agents; Antioxidants; Depression; Free Radical Scavengers; Humans; Indenes;

2010
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs.
    Advances in therapy, 2010, Volume: 27, Issue:11

    Topics: Acetamides; Benzofurans; Central Nervous System Depressants; Cyclopropanes; Depressive Disorder; Hum

2010
Sleep health and asynchronization.
    Brain & development, 2011, Volume: 33, Issue:3

    Topics: Biological Clocks; Circadian Rhythm; Cortical Synchronization; Health; Humans; Japan; Melatonin; Ser

2011
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
    International journal of geriatric psychiatry, 2010, Volume: 25, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F

2010
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis.
    Sleep, 2010, Volume: 33, Issue:12

    Topics: Adult; Central Nervous System Depressants; Child; Drug Administration Schedule; Humans; Melatonin; S

2010
A circadian rhythm sleep disorder: melatonin resets the biological clock.
    The journal of the Royal College of Physicians of Edinburgh, 2010, Volume: 40, Issue:4

    Topics: Biological Clocks; Humans; Male; Melatonin; Middle Aged; Neurotransmitter Agents; Sleep Disorders, C

2010
[Lights off? Neurobiological and pharmacological aspects of the melatonergic-serotonergic synergism].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2010, Volume: 12, Issue:4

    Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Depression; Depressive Disorder; Drug Synergism

2010
Cognition in circadian rhythm sleep disorders.
    Progress in brain research, 2011, Volume: 190

    Topics: Biological Clocks; Circadian Rhythm; Cognition; Humans; Jet Lag Syndrome; Light; Melatonin; Psychomo

2011
Jet lag and shift work sleep disorders: how to help reset the internal clock.
    Cleveland Clinic journal of medicine, 2011, Volume: 78, Issue:10

    Topics: Actigraphy; Age Factors; Benzodiazepines; Caffeine; Central Nervous System Depressants; Central Nerv

2011
Melatonin for non-respiratory sleep disorders in visually impaired children.
    The Cochrane database of systematic reviews, 2011, Nov-09, Issue:11

    Topics: Central Nervous System Depressants; Child; Disabled Children; Humans; Melatonin; Sleep Disorders, Ci

2011
The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease.
    Recent patents on endocrine, metabolic & immune drug discovery, 2011, Volume: 5, Issue:2

    Topics: Alzheimer Disease; Circadian Rhythm; Cognitive Dysfunction; Female; Humans; Male; Melatonin; Sleep D

2011
Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:5

    Topics: Brain; Child; Developmental Disabilities; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhyth

2012
Appropriate therapeutic selection for patients with shift work disorder.
    Sleep medicine, 2012, Volume: 13, Issue:4

    Topics: Central Nervous System Depressants; Central Nervous System Stimulants; Circadian Rhythm; Humans; Hyp

2012
The role of melatonin in patients with chronic kidney disease undergoing haemodialysis.
    Journal of renal care, 2012, Volume: 38, Issue:2

    Topics: Circadian Rhythm; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Kidney Fai

2012
Biological rhythms during residence in polar regions.
    Chronobiology international, 2012, Volume: 29, Issue:4

    Topics: Acclimatization; Activities of Daily Living; Affect; Antarctic Regions; Arctic Regions; Biological C

2012
[Diagnosis and treatment in circadian rhythm sleep disorders].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70, Issue:7

    Topics: Circadian Clocks; Humans; Melatonin; Phototherapy; Sleep Disorders, Circadian Rhythm

2012
Circadian typology: a comprehensive review.
    Chronobiology international, 2012, Volume: 29, Issue:9

    Topics: Aging; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Cognition; Feeding and Eating Di

2012
Circadian-based new technologies for night workers.
    Industrial health, 2002, Volume: 40, Issue:3

    Topics: Adaptation, Physiological; Circadian Rhythm; Exercise Therapy; Homeostasis; Humans; Melatonin; Perso

2002
Bright light, dark and melatonin can promote circadian adaptation in night shift workers.
    Sleep medicine reviews, 2002, Volume: 6, Issue:5

    Topics: Adaptation, Physiological; Circadian Rhythm; Humans; Light; Melatonin; Sleep Disorders, Circadian Rh

2002
Circadian rhythm sleep disorders (CRSD).
    Sleep medicine reviews, 2002, Volume: 6, Issue:1

    Topics: Antipsychotic Agents; Chronotherapy; Humans; Melatonin; Mental Disorders; Phototherapy; Sleep Disord

2002
The relevance of melatonin to sports medicine and science.
    Sports medicine (Auckland, N.Z.), 2003, Volume: 33, Issue:11

    Topics: Aging; Body Temperature; Circadian Rhythm; Exercise; Humans; Hypothermia; Jet Lag Syndrome; Melatoni

2003
Melatonin for the treatment of disorders in circadian rhythm and sleep: could it form a basis for medication?
    Receptors & channels, 2003, Volume: 9, Issue:6

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleep Deprivation; Sleep Disorders, Ci

2003
Circadian rhythm sleep disorders.
    The Medical clinics of North America, 2004, Volume: 88, Issue:3

    Topics: Body Temperature; Chronobiology Disorders; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Photo

2004
[Circadian-rhythm sleep disorders].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2004, Volume: 106, Issue:3

    Topics: Biogenic Amines; Biological Clocks; Biomarkers; Body Temperature; Circadian Rhythm; Diagnosis, Diffe

2004
Circadian rhythm disorders.
    Seminars in neurology, 2004, Volume: 24, Issue:3

    Topics: Humans; Melatonin; Sleep Disorders, Circadian Rhythm

2004
Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists.
    Sleep medicine, 2004, Volume: 5, Issue:6

    Topics: Acetamides; Antioxidants; Humans; Hypothalamus; Indenes; Indoles; Melatonin; Receptors, Melatonin; S

2004
Delayed sleep phase syndrome: pathophysiology and treatment options.
    Sleep, 2004, Sep-15, Volume: 27, Issue:6

    Topics: Antioxidants; Body Temperature; Chronotherapy; Circadian Rhythm; Combined Modality Therapy; Diagnosi

2004
Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?
    Developmental medicine and child neurology, 2004, Volume: 46, Issue:11

    Topics: Antioxidants; Brain; Child; Disability Evaluation; Disabled Children; Health Status; Humans; Melaton

2004
Melatonin as a chronobiotic.
    Sleep medicine reviews, 2005, Volume: 9, Issue:1

    Topics: Animals; Chronobiology Phenomena; Circadian Rhythm; Humans; Hydrocortisone; Melatonin; Photoperiod;

2005
Effects of exogenous melatonin on sleep: a meta-analysis.
    Sleep medicine reviews, 2005, Volume: 9, Issue:1

    Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni

2005
Effects of exogenous melatonin on sleep: a meta-analysis.
    Sleep medicine reviews, 2005, Volume: 9, Issue:1

    Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni

2005
Effects of exogenous melatonin on sleep: a meta-analysis.
    Sleep medicine reviews, 2005, Volume: 9, Issue:1

    Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni

2005
Effects of exogenous melatonin on sleep: a meta-analysis.
    Sleep medicine reviews, 2005, Volume: 9, Issue:1

    Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatoni

2005
[Melatonin and its biological significance].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2004, Volume: 17, Issue:101

    Topics: Affect; Aging; Circadian Rhythm; Humans; Immune System; Melatonin; Sleep Disorders, Circadian Rhythm

2004
Circadian rhythm sleep disorders.
    Primary care, 2005, Volume: 32, Issue:2

    Topics: Humans; Melatonin; Primary Health Care; Sleep Disorders, Circadian Rhythm; Time Factors

2005
Prevalence and comorbidity of insomnia and effect on functioning in elderly populations.
    Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:7 Suppl

    Topics: Aged; Comorbidity; Humans; Hypnotics and Sedatives; Light; Melatonin; Prevalence; Sleep Disorders, C

2005
[Sleep and circadian rhythms in ageing].
    Zeitschrift fur Gerontologie und Geriatrie, 2005, Volume: 38 Suppl 1

    Topics: Aged, 80 and over; Aging; Circadian Rhythm; Humans; Light; Melatonin; Photic Stimulation; Sleep; Sle

2005
[Sleep disruption in shift work and jet lag: the role of the circadian timing system].
    Praxis, 2005, Sep-21, Volume: 94, Issue:38

    Topics: Adult; Antioxidants; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Humans; Hypnotic

2005
[Does exogenous melatonin prove to be effective in the prevention and treatment of pathologies associated with shift and night work?].
    Medycyna pracy, 2005, Volume: 56, Issue:3

    Topics: Adaptation, Physiological; Circadian Rhythm; Humans; Melatonin; Personnel Staffing and Scheduling; S

2005
The human circadian system in normal and disordered sleep.
    The Journal of clinical psychiatry, 2005, Volume: 66 Suppl 9

    Topics: Biological Clocks; Circadian Rhythm; Humans; Jet Lag Syndrome; Light; Melatonin; Receptors, Melatoni

2005
The use of chronobiotics in the resynchronization of the sleep-wake cycle.
    Cancer causes & control : CCC, 2006, Volume: 17, Issue:4

    Topics: Animals; Chronotherapy; Humans; Jet Lag Syndrome; Light; Melatonin; Sleep; Sleep Disorders, Circadia

2006
Sleep, rhythms and women's mood. Part II. Menopause.
    Sleep medicine reviews, 2006, Volume: 10, Issue:3

    Topics: Adult; Circadian Rhythm; Female; Hormone Replacement Therapy; Hot Flashes; Humans; Hydrocortisone; M

2006
Melatonin and human rhythms.
    Chronobiology international, 2006, Volume: 23, Issue:1-2

    Topics: Biological Clocks; Chronobiology Disorders; Chronobiology Phenomena; Circadian Rhythm; Humans; Light

2006
Melatonin in mood disorders.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:3

    Topics: Antidepressive Agents; Biomarkers; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Depressi

2006
The brain's master circadian clock: implications and opportunities for therapy of sleep disorders.
    Sleep medicine reviews, 2007, Volume: 11, Issue:1

    Topics: Antioxidants; Body Temperature; Circadian Rhythm; Humans; Hypothalamus; Melatonin; Phototherapy; Pit

2007
Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology.
    Eye (London, England), 2007, Volume: 21, Issue:7

    Topics: Animals; Circadian Rhythm; Humans; Light; Melatonin; Ocular Physiological Phenomena; Pineal Gland; R

2007
Promoting adjustment of the sleep-wake cycle by chronobiotics.
    Physiology & behavior, 2007, Feb-28, Volume: 90, Issue:2-3

    Topics: Chronobiology Phenomena; Chronotherapy; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders,

2007
[Synchronization and desynchronization of the biological clock in man].
    L'Encephale, 2006, Volume: 32, Issue:5 Pt 2

    Topics: Adult; Child; Chronobiology Disorders; Circadian Rhythm; Homeostasis; Humans; Melatonin; Mental Diso

2006
[Change in rhythms with age].
    L'Encephale, 2006, Volume: 32, Issue:5 Pt 2

    Topics: Activity Cycles; Aged; Aging; Arousal; Body Temperature Regulation; Circadian Rhythm; Hormones; Huma

2006
Shift work sleep disorder: burden of illness and approaches to management.
    Drugs, 2006, Volume: 66, Issue:18

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cost of Illness

2006
Melatonin and sleep disorders associated with intellectual disability: a clinical review.
    Journal of intellectual disability research : JIDR, 2007, Volume: 51, Issue:Pt 1

    Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Dr

2007
Clinical management of delayed sleep phase disorder.
    Behavioral sleep medicine, 2007, Volume: 5, Issue:1

    Topics: Antioxidants; Chronotherapy; Combined Modality Therapy; Humans; Melatonin; Phototherapy; Polysomnogr

2007
Treating chronobiological components of chronic insomnia.
    Sleep medicine, 2007, Volume: 8, Issue:6

    Topics: Behavior Therapy; Biological Clocks; Body Temperature; Chronic Disease; Chronotherapy; Circadian Rhy

2007
A clinical approach to circadian rhythm sleep disorders.
    Sleep medicine, 2007, Volume: 8, Issue:6

    Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Health Knowledge, Attitudes, Practice; Humans;

2007
Jet lag: trends and coping strategies.
    Lancet (London, England), 2007, Mar-31, Volume: 369, Issue:9567

    Topics: Adaptation, Psychological; Humans; Jet Lag Syndrome; Melatonin; Sleep Disorders, Circadian Rhythm; S

2007
Circadian rhythm sleep disorders in the blind and their treatment with melatonin.
    Sleep medicine, 2007, Volume: 8, Issue:6

    Topics: Blindness; Chronotherapy; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhy

2007
Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome.
    Sleep medicine reviews, 2007, Volume: 11, Issue:6

    Topics: Adolescent; Biological Clocks; Body Temperature; Circadian Rhythm; Humans; Melatonin; Phototherapy;

2007
Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report.
    Sleep, 2007, Volume: 30, Issue:11

    Topics: Antioxidants; Humans; Melatonin; Phototherapy; Polysomnography; Sleep; Sleep Disorders, Circadian Rh

2007
Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review.
    Sleep, 2007, Volume: 30, Issue:11

    Topics: Adult; Antioxidants; Central Nervous System Stimulants; Drug Therapy; Female; Humans; Male; Melatoni

2007
Circadian rhythmicity and the pharmacologic management of insomnia.
    The American journal of managed care, 2007, Volume: 13, Issue:5 Suppl

    Topics: Chronotherapy; Cost-Benefit Analysis; Humans; Hypnotics and Sedatives; Managed Care Programs; Melato

2007
Diagnosis of circadian rhythm sleep disorders.
    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 2008, Volume: 34, Issue:3

    Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Phototherapy; Polysomnograph

2008
Melatonin, sleep, and circadian rhythm disorders.
    Seminars in clinical neuropsychiatry, 2000, Volume: 5, Issue:1

    Topics: Brain; Brain Mapping; Circadian Rhythm; Humans; Melatonin; Pituitary Gland; Risk Factors; Sleep Diso

2000
Sleep/wake cycle and circadian disturbances in shift work: strategies for their management--a review.
    Annals of the Academy of Medicine, Singapore, 2000, Volume: 29, Issue:1

    Topics: Humans; Lighting; Melatonin; Occupational Health; Personnel Staffing and Scheduling; Sleep Disorders

2000
Circadian rhythm sleep disorders: pathophysiology and potential approaches to management.
    CNS drugs, 2001, Volume: 15, Issue:4

    Topics: Animals; Chronotherapy; Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Sleep; Sleep Disorders, C

2001
Health in a 24-h society.
    Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286

    Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,

2001
Health in a 24-h society.
    Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286

    Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,

2001
Health in a 24-h society.
    Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286

    Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,

2001
Health in a 24-h society.
    Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286

    Topics: Accidents, Occupational; Chronobiology Phenomena; Health Status; Humans; Melatonin; Sleep Disorders,

2001
Sleep, sleepiness, and alcohol use.
    Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2001, Volume: 25, Issue:2

    Topics: Alcohol Drinking; Alcoholism; Animals; Dose-Response Relationship, Drug; Ethanol; Humans; Melatonin;

2001
[Physiology of the biological clock and the relation of circadian rhythm disorders to illnesses].
    Duodecim; laaketieteellinen aikakauskirja, 1999, Volume: 115, Issue:5

    Topics: Animals; Biological Clocks; Blindness; Chronobiology Disorders; Humans; Jet Lag Syndrome; Light; Mel

1999
[Delayed wakefulness-sleep rhythm syndrome and melatonin. Synthesis of existing studies].
    Revue neurologique, 2001, Volume: 157, Issue:11 Pt 2

    Topics: Circadian Rhythm; Clinical Trials as Topic; Humans; Melatonin; Sleep Disorders, Circadian Rhythm; Tr

2001
[Delayed sleep phase insomnia].
    Duodecim; laaketieteellinen aikakauskirja, 1999, Volume: 115, Issue:24

    Topics: Circadian Rhythm; Diagnosis, Differential; Humans; Melatonin; Quality of Life; Severity of Illness I

1999
[Melatonin treatment of sleep disorders in disabled children].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2002, Apr-20, Volume: 122, Issue:10

    Topics: Administration, Oral; Child; Child, Preschool; Developmental Disabilities; Disabled Children; Humans

2002

Trials

39 trials available for melatonin and Sleep Disorders, Circadian Rhythm

ArticleYear
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.
    Journal of pineal research, 2022, Volume: 73, Issue:1

    Topics: Aged; Circadian Rhythm; Cross-Over Studies; Humans; Melatonin; Middle Aged; Quality of Life; Sleep;

2022
Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial.
    BMJ open, 2022, 07-04, Volume: 12, Issue:7

    Topics: Anticonvulsants; Child, Preschool; Dietary Supplements; Humans; Infant; Melatonin; Neuroprotective A

2022
Attention-Deficit/Hyperactivity Disorder and Delayed Sleep Phase Syndrome in Adults: A Randomized Clinical Trial on the Effects of Chronotherapy on Sleep.
    Journal of biological rhythms, 2022, Volume: 37, Issue:6

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chronotherapy; Circadian Rhythm; Humans; Melat

2022
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
    Journal of biological rhythms, 2023, Volume: 38, Issue:1

    Topics: Child, Preschool; Circadian Clocks; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep; Sleep

2023
Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: a randomized clinical trial.
    Chronobiology international, 2021, Volume: 38, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chronotherapy; Circadian Rhythm; Humans; Light

2021
Identification of a Preliminary Plasma Metabolome-based Biomarker for Circadian Phase in Humans.
    Journal of biological rhythms, 2021, Volume: 36, Issue:4

    Topics: Biomarkers; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Metabolome; Sleep; Sleep Disor

2021
Randomised controlled trial of the efficacy of a blue-enriched light intervention to improve alertness and performance in night shift workers.
    Occupational and environmental medicine, 2017, Volume: 74, Issue:11

    Topics: Adult; Attention; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Sleep; Sleep Disorders,

2017
Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder.
    Sleep medicine, 2019, Volume: 58

    Topics: Adult; Australia; Biological Variation, Population; Case-Control Studies; Central Nervous System Dep

2019
Long-term effects of melatonin on quality of life and sleep in haemodialysis patients (Melody study): a randomized controlled trial.
    British journal of clinical pharmacology, 2013, Volume: 76, Issue:5

    Topics: Actigraphy; Aged; Antioxidants; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies;

2013
Effects of filtering visual short wavelengths during nocturnal shiftwork on sleep and performance.
    Chronobiology international, 2013, Volume: 30, Issue:8

    Topics: Adult; Affect; Analysis of Variance; Circadian Rhythm; Employee Performance Appraisal; Female; Human

2013
A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: effects on subjective and objective sleepiness and cognitive function.
    Journal of biological rhythms, 2013, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Circadian Rhythm; Cognition; Double-Blind Method; Fatigue; Female; Humans; Male;

2013
Glucocorticoids entrain molecular clock components in human peripheral cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:4

    Topics: Adult; ARNTL Transcription Factors; Circadian Rhythm; Double-Blind Method; Drug Administration Sched

2015
The effects of kidney transplantation on sleep, melatonin, circadian rhythm and quality of life in kidney transplant recipients and living donors.
    Nephron, 2015, Volume: 129, Issue:1

    Topics: Adult; Aged; Blood Pressure; Body Temperature; Circadian Rhythm; Female; Humans; Kidney Failure, Chr

2015
Sleep deficits in the High Arctic summer in relation to light exposure and behaviour: use of melatonin as a countermeasure.
    Sleep medicine, 2015, Volume: 16, Issue:3

    Topics: Actigraphy; Adult; Arctic Regions; Canada; Central Nervous System Depressants; Circadian Rhythm; Fem

2015
Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms.
    Sleep medicine, 2015, Volume: 16, Issue:6

    Topics: Affect; Aged; Arousal; Blindness; Caffeine; Circadian Clocks; Humans; Male; Melatonin; Middle Aged;

2015
Home dim light melatonin onsets with measures of compliance in delayed sleep phase disorder.
    Journal of sleep research, 2016, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Housing; Humans; Light; Lighting; Melatonin; Middle Age

2016
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome.
    Sleep medicine, 2009, Volume: 10, Issue:5

    Topics: Adolescent; Adult; Circadian Rhythm; Cohort Studies; Female; Humans; Light; Male; Melatonin; Polysom

2009
The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study).
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Female; H

2009
Night shift performance is improved by a compromise circadian phase position: study 3. Circadian phase after 7 night shifts with an intervening weekend off.
    Sleep, 2008, Volume: 31, Issue:12

    Topics: Adaptation, Physiological; Adult; Arousal; Attention; Chronotherapy; Circadian Rhythm; Feasibility S

2008
Use of transdermal melatonin delivery to improve sleep maintenance during daytime.
    Clinical pharmacology and therapeutics, 2009, Volume: 86, Issue:4

    Topics: Administration, Cutaneous; Adult; Body Temperature; Central Nervous System Depressants; Circadian Rh

2009
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome.
    Sleep medicine, 2010, Volume: 11, Issue:2

    Topics: Adult; Central Nervous System Depressants; Circadian Rhythm; Cross-Over Studies; Depression; Double-

2010
Lack of short-wavelength light during the school day delays dim light melatonin onset (DLMO) in middle school students.
    Neuro endocrinology letters, 2010, Volume: 31, Issue:1

    Topics: Adolescent; Biological Clocks; Circadian Rhythm; Eyeglasses; Female; Humans; Light; Lighting; Male;

2010
Effects of an advanced sleep schedule and morning short wavelength light exposure on circadian phase in young adults with late sleep schedules.
    Sleep medicine, 2011, Volume: 12, Issue:7

    Topics: Affect; Circadian Rhythm; Color; Dose-Response Relationship, Radiation; Female; Humans; Light; Male;

2011
Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stress.
    Sleep medicine, 2011, Volume: 12, Issue:9

    Topics: Central Nervous System Depressants; Child; Child Behavior; Child, Preschool; Drug Administration Sch

2011
The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans.
    Journal of pineal research, 2012, Volume: 53, Issue:1

    Topics: Adult; Circadian Clocks; Cross-Sectional Studies; Electroencephalography; Female; Humans; Male; Mela

2012
Intrinsic circadian period of sighted patients with circadian rhythm sleep disorder, free-running type.
    Biological psychiatry, 2013, Jan-01, Volume: 73, Issue:1

    Topics: Adolescent; Adult; Case-Control Studies; Chronotherapy; Circadian Rhythm; Female; Humans; Indenes; M

2013
Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness.
    Sleep, 2004, May-01, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Circadian Rhythm;

2004
Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial.
    Brain & development, 2004, Volume: 26, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Cros

2004
Phase-dependent treatment of delayed sleep phase syndrome with melatonin.
    Sleep, 2005, Volume: 28, Issue:10

    Topics: Adult; Antioxidants; Circadian Rhythm; Drug Administration Schedule; Female; Humans; Male; Melatonin

2005
Morning melatonin has limited benefit as a soporific for daytime sleep after night work.
    Chronobiology international, 2005, Volume: 22, Issue:5

    Topics: Adult; Circadian Rhythm; Darkness; Delayed-Action Preparations; Female; Humans; Light; Male; Melaton

2005
Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent.
    Sleep, 2006, Volume: 29, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Antioxidants; Body Temperature; Circadian Rhythm; Double-Bl

2006
Subjective and objective measures of adaptation and readaptation to night work on an oil rig in the North Sea.
    Sleep, 2006, Volume: 29, Issue:6

    Topics: Adaptation, Physiological; Adult; Antioxidants; Cross-Over Studies; Disorders of Excessive Somnolenc

2006
Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work.
    Scandinavian journal of work, environment & health, 2007, Volume: 33, Issue:3

    Topics: Adaptation, Psychological; Adult; Analysis of Variance; Circadian Rhythm; Cross-Over Studies; Double

2007
Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders.
    Journal of pineal research, 2007, Volume: 43, Issue:4

    Topics: Central Nervous System Depressants; Child; Cross-Over Studies; Delayed-Action Preparations; Double-B

2007
Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease.
    Journal of the American Geriatrics Society, 2008, Volume: 56, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Circadian Rhythm; Female; Humans; Linear M

2008
A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities.
    Journal of pineal research, 2008, Volume: 44, Issue:1

    Topics: Adolescent; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive; Child

2008
Effects of melatonin administration on daytime sleep after simulated night shift work.
    Journal of sleep research, 2001, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Antioxidants; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Electroc

2001
Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:2

    Topics: Adjuvants, Immunologic; Adult; Affect; Body Temperature; Circadian Rhythm; Female; Humans; Jet Lag S

2002
Bright-light mask treatment of delayed sleep phase syndrome.
    Journal of biological rhythms, 2002, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Affect; Circadian Rhythm; Double-Blind Method; Female; Follow-Up Studies; Humans;

2002

Other Studies

193 other studies available for melatonin and Sleep Disorders, Circadian Rhythm

ArticleYear
Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24-h melatonin rhythm with antiphasic daytime and nighttime peaks.
    Journal of pineal research, 2022, Volume: 72, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Work Schedule Toleran

2022
Natural light exposure and circadian rhythm: a potential therapeutic approach for disorders of consciousness.
    Sleep, 2022, 07-11, Volume: 45, Issue:7

    Topics: Circadian Rhythm; Consciousness; Humans; Light; Melatonin; Sleep Disorders, Circadian Rhythm

2022
Ultra-low-dose early night ramelteon administration for the treatment of delayed sleep-wake phase disorder: case reports with a pharmacological review.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022, 12-01, Volume: 18, Issue:12

    Topics: Circadian Rhythm; Humans; Indenes; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake D

2022
A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study.
    Chronobiology international, 2023, Volume: 40, Issue:2

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Saliva; Sleep; Sleep Disorders, Circadian Rhythm; Young

2023
A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study.
    Chronobiology international, 2023, Volume: 40, Issue:2

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Saliva; Sleep; Sleep Disorders, Circadian Rhythm; Young

2023
A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study.
    Chronobiology international, 2023, Volume: 40, Issue:2

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Saliva; Sleep; Sleep Disorders, Circadian Rhythm; Young

2023
A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study.
    Chronobiology international, 2023, Volume: 40, Issue:2

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Saliva; Sleep; Sleep Disorders, Circadian Rhythm; Young

2023
Melatonin Treatment of Circadian Rhythm Sleep-Wake Disorder in Obese Children Affects the Brain-Derived Neurotrophic Factor Level.
    Neuropediatrics, 2023, Volume: 54, Issue:4

    Topics: Brain-Derived Neurotrophic Factor; Child; Circadian Rhythm; Humans; Melatonin; Pediatric Obesity; Sl

2023
Continuous positive airway pressure as an accurate marker for non-24-hour sleep-wake rhythm disorder.
    Journal of sleep research, 2023, Volume: 32, Issue:4

    Topics: Autism Spectrum Disorder; Circadian Rhythm; Continuous Positive Airway Pressure; Humans; Male; Melat

2023
Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals with non-24-hour sleep-wake rhythm disorder.
    Sleep, 2023, 06-13, Volume: 46, Issue:6

    Topics: Circadian Rhythm; CLOCK Proteins; East Asian People; Humans; Melatonin; Receptors, Cytoplasmic and N

2023
Structural properties and binding mechanism of DNA aptamers sensing saliva melatonin for diagnosis and monitoring of circadian clock and sleep disorders.
    Analytica chimica acta, 2023, Apr-22, Volume: 1251

    Topics: Aptamers, Nucleotide; Circadian Clocks; Circadian Rhythm; Humans; Melatonin; Saliva; Sleep Disorders

2023
The Effect of Blindness on Biological Rhythms and the Consequences of Circadian Rhythm Disorder.
    Turkish journal of ophthalmology, 2023, 04-20, Volume: 53, Issue:2

    Topics: Blindness; Humans; Melatonin; Periodicity; Sleep Disorders, Circadian Rhythm

2023
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
    Science (New York, N.Y.), 2023, 07-21, Volume: 381, Issue:6655

    Topics: Animals; Circadian Rhythm; Fibrosis; Heart Diseases; Humans; Macrophages; Melatonin; Mice; Pineal Gl

2023
Heart failure causes sleepless nights.
    Science (New York, N.Y.), 2023, 07-21, Volume: 381, Issue:6655

    Topics: Heart Failure; Humans; Melatonin; Pineal Gland; Sleep Disorders, Circadian Rhythm

2023
Sleep impairment and altered pattern of circadian biomarkers during a long-term Antarctic summer camp.
    Scientific reports, 2023, 09-25, Volume: 13, Issue:1

    Topics: Antarctic Regions; Circadian Rhythm; Disorders of Excessive Somnolence; Humans; Melatonin; Sleep; Sl

2023
Colorimetric sensing assay based on aptamer-gold nanoparticles for rapid detection of salivary melatonin to monitor circadian rhythm sleep disorders.
    Analytica chimica acta, 2023, Oct-23, Volume: 1279

    Topics: Circadian Rhythm; Colorimetry; Gold; Humans; Melatonin; Metal Nanoparticles; Reproducibility of Resu

2023
Delayed Sleep Phase Syndrome.
    American journal of respiratory and critical care medicine, 2019, 08-15, Volume: 200, Issue:4

    Topics: Central Nervous System Depressants; Humans; Melatonin; Phototherapy; Sleep Disorders, Circadian Rhyt

2019
Home versus laboratory assessments of melatonin production and melatonin onset in young adults complaining of a delayed sleep schedule.
    Journal of sleep research, 2020, Volume: 29, Issue:3

    Topics: Adult; Circadian Rhythm; Female; Humans; Laboratories; Male; Melatonin; Sleep Disorders, Circadian R

2020
Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy.
    Scientific reports, 2020, 01-31, Volume: 10, Issue:1

    Topics: Adie Syndrome; Aged; Cells, Cultured; Circadian Clocks; Cross-Sectional Studies; Diabetes Mellitus,

2020
Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis.
    Chronobiology international, 2020, Volume: 37, Issue:6

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Apnea, Obstructive; Sleep Disorders, Circadian Rhy

2020
Sleep and circadian instability in delayed sleep-wake phase disorder.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2020, 09-15, Volume: 16, Issue:9

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders

2020
Sleep duration and timing in obsessive-compulsive disorder (OCD): evidence for circadian phase delay.
    Sleep medicine, 2020, Volume: 72

    Topics: Circadian Rhythm; Humans; Melatonin; Obsessive-Compulsive Disorder; Sleep; Sleep Disorders, Circadia

2020
Circadian tau differences and rhythm associations in delayed sleep-wake phase disorder and sighted non-24-hour sleep-wake rhythm disorder.
    Sleep, 2021, 01-21, Volume: 44, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sl

2021
Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2020, 12-15, Volume: 16, Issue:12

    Topics: Adolescent; Biomarkers; Child; Circadian Rhythm; Female; Humans; Insulin-Like Growth Factor I; Male;

2020
Exposure to Radiation During Work Shifts and Working at Night Act as Occupational Stressors Alter Redox and Inflammatory Markers.
    Archives of medical research, 2021, Volume: 52, Issue:1

    Topics: Adult; Antioxidants; Biomarkers; Case-Control Studies; Egypt; Female; Humans; Hydrocortisone; Inflam

2021
Association between circadian rhythm disruption and polycystic ovary syndrome.
    Fertility and sterility, 2021, Volume: 115, Issue:3

    Topics: Adult; Animals; Animals, Newborn; Chronobiology Disorders; Circadian Rhythm; Female; Granulosa Cells

2021
Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances.
    Journal of pineal research, 2021, Volume: 70, Issue:3

    Topics: Adolescent; Autistic Disorder; Biomarkers; Case-Control Studies; Child; Child, Preschool; Circadian

2021
Melatonin (MEL) and its use in circadian rhythm sleep-wake disorders: Recommendations of the French Medical and Research Sleep Society (SFRMS).
    Revue neurologique, 2021, Volume: 177, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm

2021
Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.
    Sleep, 2021, 05-14, Volume: 44, Issue:5

    Topics: Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sle

2021
Timely use of in-car dim blue light and blue blockers in the morning does not improve circadian adaptation of fast rotating shift workers.
    Chronobiology international, 2021, Volume: 38, Issue:5

    Topics: Automobiles; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Wakefuln

2021
Advances in the pharmacological management of non-24-h sleep-wake disorder.
    Expert opinion on pharmacotherapy, 2021, Volume: 22, Issue:8

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders

2021
Sleep deprivation therapy to reset the circadian pacemaker in a non-24-hour sleep-wake disorder: a case report.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021, 07-01, Volume: 17, Issue:7

    Topics: Circadian Rhythm; Humans; Male; Melatonin; Sleep; Sleep Deprivation; Sleep Disorders, Circadian Rhyt

2021
Metabolomic Profiles of Shift Workers and Day Workers: A Cross-Sectional Study.
    Obesity (Silver Spring, Md.), 2021, Volume: 29, Issue:6

    Topics: Adult; Case-Control Studies; Cholesterol; Cholesterol, LDL; Circadian Rhythm; Cross-Sectional Studie

2021
Treatment of a patient with a circadian sleep-wake disorder using a combination of melatonin and metoprolol.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021, 10-01, Volume: 17, Issue:10

    Topics: Circadian Rhythm; Humans; Melatonin; Metoprolol; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wak

2021
Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers.
    Journal of pineal research, 2021, Volume: 71, Issue:2

    Topics: Biomarkers; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Sleep; Sleep Disorders, Circad

2021
Behaviorally and environmentally induced non-24-hour sleep-wake rhythm disorder in sighted patients.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022, Feb-01, Volume: 18, Issue:2

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders

2022
Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder.
    Sleep, 2017, Jan-01, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Affect; Circadian Rhythm; Depression; Female; Humans; Light; Male; Melatonin; Mid

2017
Young children with Down syndrome show normal development of circadian rhythms, but poor sleep efficiency: a cross-sectional study across the first 60 months of life.
    Sleep medicine, 2017, Volume: 33

    Topics: Actigraphy; Child; Child, Preschool; Circadian Rhythm; Cross-Sectional Studies; Down Syndrome; Femal

2017
Circadian phase, dynamics of subjective sleepiness and sensitivity to blue light in young adults complaining of a delayed sleep schedule.
    Sleep medicine, 2017, Volume: 34

    Topics: Adult; Circadian Rhythm; Enzyme-Linked Immunosorbent Assay; Female; Humans; Light; Male; Melatonin;

2017
Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing.
    Scientific reports, 2017, 06-12, Volume: 7, Issue:1

    Topics: Academic Performance; Adolescent; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Models,

2017
Clinical Sleep-Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders.
    Handbook of experimental pharmacology, 2019, Volume: 253

    Topics: Circadian Rhythm; Humans; Melatonin; Quality of Life; Sleep; Sleep Disorders, Circadian Rhythm; Slee

2019
Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017, Nov-15, Volume: 13, Issue:11

    Topics: Adolescent; Central Nervous System Depressants; Cysts; Female; Humans; Melatonin; Pineal Gland; Slee

2017
Circadian Phase and Phase Angle Disorders in Primary Insomnia.
    Sleep, 2017, 12-01, Volume: 40, Issue:12

    Topics: Adult; Australia; Child; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Male; Melatonin;

2017
Non-24-Hour Sleep-Wake Circadian Rhythm Disorder in a Sighted Male With Normal Functioning.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018, 03-15, Volume: 14, Issue:3

    Topics: Actigraphy; Adult; Central Nervous System Depressants; Humans; Male; Melatonin; Polysomnography; Sle

2018
Daily Profiles of Light Exposure and Evening Use of Light-emitting Devices in Young Adults Complaining of a Delayed Sleep Schedule.
    Journal of biological rhythms, 2018, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Circadian Rhythm; Computers; Female; Humans; Light; Lighting; Male; Melatonin; Ph

2018
Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder.
    The Journal of physiology, 2018, Volume: 596, Issue:24

    Topics: Case-Control Studies; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep Disorders, Circadian

2018
Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy.
    Sleep medicine, 2019, Volume: 54

    Topics: Actigraphy; Circadian Rhythm; Diabetes Mellitus; Diabetic Retinopathy; Female; Humans; Hydrocortison

2019
Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital Nurses.
    Journal of biological rhythms, 2019, Volume: 34, Issue:2

    Topics: Adult; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Female; Gene Expression Regulati

2019
Salivary melatonin onset in youth at familial risk for bipolar disorder.
    Psychiatry research, 2019, Volume: 274

    Topics: Adolescent; Adult; Biomarkers; Bipolar Disorder; Child; Circadian Rhythm; Female; Genetic Predisposi

2019
Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder?
    Journal of the American Academy of Child and Adolescent Psychiatry, 2019, Volume: 58, Issue:3

    Topics: Adolescent; Antioxidants; Anxiety; Chronotherapy; Circadian Rhythm; Combined Modality Therapy; Depre

2019
The Impact of Shift Work on Sleep, Alertness and Performance in Healthcare Workers.
    Scientific reports, 2019, 03-15, Volume: 9, Issue:1

    Topics: Adult; Attention; Circadian Rhythm; Fatigue; Female; Health Personnel; Humans; Male; Melatonin; Midd

2019
Sleepiness and driving events in shift workers: the impact of circadian and homeostatic factors.
    Sleep, 2019, 06-11, Volume: 42, Issue:6

    Topics: Actigraphy; Adult; Automobile Driving; Circadian Rhythm; Cognition; Female; Homeostasis; Humans; Mal

2019
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
    The Journal of clinical endocrinology and metabolism, 2019, 08-01, Volume: 104, Issue:8

    Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin

2019
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
    The Journal of clinical endocrinology and metabolism, 2019, 08-01, Volume: 104, Issue:8

    Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin

2019
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
    The Journal of clinical endocrinology and metabolism, 2019, 08-01, Volume: 104, Issue:8

    Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin

2019
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
    The Journal of clinical endocrinology and metabolism, 2019, 08-01, Volume: 104, Issue:8

    Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin

2019
Correlation among clock gene expression rhythms, sleep quality, and meal conditions in delayed sleep-wake phase disorder and night eating syndrome.
    Chronobiology international, 2019, Volume: 36, Issue:6

    Topics: Adult; Circadian Rhythm; Feeding Behavior; Gene Expression; Humans; Male; Meals; Melatonin; Night Ea

2019
Management of a rare case of advanced sleep phase disorder in a patient with persistent depressive disorder.
    Asian journal of psychiatry, 2019, Volume: 43

    Topics: Aged; Central Nervous System Depressants; Cognitive Behavioral Therapy; Depressive Disorder; Disease

2019
Monitoring salivary melatonin concentrations in children with sleep disorders using liquid chromatography-tandem mass spectrometry.
    Therapeutic drug monitoring, 2013, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chromatography, Liquid; Chromatography, Rev

2013
The endogenous circadian temperature period length (tau) in delayed sleep phase disorder compared to good sleepers.
    Journal of sleep research, 2013, Volume: 22, Issue:6

    Topics: Adult; Body Temperature; Case-Control Studies; Circadian Rhythm; Cues; Female; Humans; Male; Melaton

2013
Body temperature, activity and melatonin profiles in adults with attention-deficit/hyperactivity disorder and delayed sleep: a case-control study.
    Journal of sleep research, 2013, Volume: 22, Issue:6

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Body Temperature; Case-Control Studies; Circad

2013
Why do we sleep so late?
    Journal of sleep research, 2013, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Attention Deficit Disorder with Hyperactivity; Circadian

2013
The biological clock modulates the human cortisol response in a multiplicative fashion.
    Chronobiology international, 2014, Volume: 31, Issue:4

    Topics: Activity Cycles; Biological Clocks; Biomarkers; Circadian Rhythm; Humans; Hydrocortisone; Male; Mela

2014
Challenging behaviour and sleep cycle disorder following brain injury: a preliminary response to agomelatine treatment.
    Brain injury, 2014, Volume: 28, Issue:3

    Topics: Acetamides; Brain Injuries; Cognition Disorders; Humans; Hypnotics and Sedatives; Male; Melatonin; M

2014
Headache and sleep: also assess circadian rhythm sleep disorders.
    Headache, 2014, Volume: 54, Issue:1

    Topics: Biomarkers; Headache; Humans; Melatonin; Saliva; Sleep; Sleep Disorders, Circadian Rhythm

2014
Headache and sleep: also assess circadian rhythm sleep disorders: a response.
    Headache, 2014, Volume: 54, Issue:1

    Topics: Headache; Humans; Melatonin; Saliva; Sleep Disorders, Circadian Rhythm

2014
Persistence of fertility despite semen alterations in a pinealectomised patient treated with melatonin.
    Neuro endocrinology letters, 2013, Volume: 34, Issue:8

    Topics: Adult; Central Nervous System Depressants; Female; Fertility; Humans; Male; Melatonin; Pineal Gland;

2013
Sleep loss, circadian mismatch, and abnormalities in reorienting of attention in night workers with shift work disorder.
    Sleep, 2014, Mar-01, Volume: 37, Issue:3

    Topics: Adult; Attention; Brain; Circadian Rhythm; Evoked Potentials; Female; Hospitals; Humans; Light; Male

2014
Introduction: circadian rhythm and its disruption: impact on reproductive function.
    Fertility and sterility, 2014, Volume: 102, Issue:2

    Topics: Animals; Circadian Clocks; Circadian Rhythm; Female; Humans; Hydrocortisone; Light; Male; Melatonin;

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Lack of association of the NPAS2 gene Ala394Thr polymorphism (rs2305160:G>A) with risk of chronic lymphocytic leukemia.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:17

    Topics: Aged; Asian People; Basic Helix-Loop-Helix Transcription Factors; Case-Control Studies; Female; Gene

2014
[Light pollution, desynchronosis and aging: the state of problem and solutions].
    Advances in gerontology = Uspekhi gerontologii, 2014, Volume: 27, Issue:2

    Topics: Aging; Aging, Premature; Animals; Antioxidants; Humans; Light; Lighting; Longevity; Melatonin; Model

2014
Differential sleep, sleepiness, and neurophysiology in the insomnia phenotypes of shift work disorder.
    Sleep, 2015, Jan-01, Volume: 38, Issue:1

    Topics: Alleles; Attention; Brain; Case-Control Studies; Circadian Rhythm; Disorders of Excessive Somnolence

2015
The central clock in patients with Parkinson disease.
    JAMA neurology, 2014, Volume: 71, Issue:11

    Topics: Chronobiology Disorders; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male;

2014
The central clock in patients with Parkinson disease--reply.
    JAMA neurology, 2014, Volume: 71, Issue:11

    Topics: Chronobiology Disorders; Circadian Rhythm; Disorders of Excessive Somnolence; Female; Humans; Male;

2014
Length polymorphism in the Period 3 gene is associated with sleepiness and maladaptive circadian phase in night-shift workers.
    Journal of sleep research, 2015, Volume: 24, Issue:3

    Topics: Adult; Alleles; Case-Control Studies; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Peri

2015
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
    Sao Paulo medical journal = Revista paulista de medicina, 2015, Volume: 133, Issue:1

    Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Wakefulness-Pr

2015
Insomnia in shift work disorder relates to occupational and neurophysiological impairment.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015, Apr-15, Volume: 11, Issue:4

    Topics: Adult; Brain; Cognition Disorders; Efficiency; Evoked Potentials; Female; Humans; Male; Melatonin; S

2015
Light at Night and Measures of Alertness and Performance: Implications for Shift Workers.
    Biological research for nursing, 2016, Volume: 18, Issue:1

    Topics: Adult; Attention; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Reaction Time; Sleep Dis

2016
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
    JAMA, 2015, Mar-03, Volume: 313, Issue:9

    Topics: Humans; Hypnotics and Sedatives; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Wakefulness-Pr

2015
Ocular Measures of Sleepiness Are Increased in Night Shift Workers Undergoing a Simulated Night Shift Near the Peak Time of the 6-Sulfatoxymelatonin Rhythm.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015, Oct-15, Volume: 11, Issue:10

    Topics: Adolescent; Adult; Blinking; Circadian Rhythm; Electroencephalography; Female; Humans; Male; Melaton

2015
Effect of Sleep/Wake Cycle on Autonomic Regulation.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2015, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Age Factors; Autonomic Nervous System; Biological Clocks; Circadian Rhythm; Cross

2015
An observational study on disturbed peripheral circadian rhythms in hemodialysis patients.
    Chronobiology international, 2015, Volume: 32, Issue:6

    Topics: Aged; Biomarkers; Cell Line; Circadian Rhythm; Fatigue; Female; Gene Expression Profiling; Humans; H

2015
[Sleep disorders and circadian rhythms in diseases of the cardiovascular system].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:3

    Topics: Aged; Cardiovascular Diseases; Circadian Rhythm; Cognition Disorders; Female; Humans; Male; Melatoni

2015
Nocturnal Melatonin Profiles in Patients with Delayed Sleep-Wake Phase Disorder and Control Sleepers.
    Journal of biological rhythms, 2015, Volume: 30, Issue:5

    Topics: Actigraphy; Adolescent; Adult; Analysis of Variance; Circadian Rhythm; Female; Humans; Immunoassay;

2015
Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the Dim Light Melatonin Onset.
    Journal of biological rhythms, 2015, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Chronobiology Phenomena; Circadian Rhythm; Female; Humans; Light; Linear Models;

2015
Sleep interruption associated with house staff work schedules alters circadian gene expression.
    Sleep medicine, 2015, Volume: 16, Issue:11

    Topics: Adult; Animals; Biomarkers; Circadian Clocks; Circadian Rhythm; Cross-Over Studies; Female; Gene Exp

2015
Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.
    Journal of biological rhythms, 2016, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Pineal Gland; Pinealoma; Prosp

2016
Protective effect of blue-light shield eyewear for adults against light pollution from self-luminous devices used at night.
    Chronobiology international, 2016, Volume: 33, Issue:1

    Topics: Adult; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Photoperiod; Sleep Disorders, Circa

2016
Shift Work, Chronotype, and Melatonin Patterns among Female Hospital Employees on Day and Night Shifts.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016, Volume: 25, Issue:5

    Topics: Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Personnel, Hospital; Sleep Disorders

2016
Correlations between behavior, memory, sleep-wake and melatonin in Williams-Beuren syndrome.
    Physiology & behavior, 2016, May-15, Volume: 159

    Topics: Adolescent; Child; Child Behavior; Circadian Clocks; Cross-Sectional Studies; Female; Humans; Male;

2016
Ancestral sleep.
    Current biology : CB, 2016, Apr-04, Volume: 26, Issue:7

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Photoperiod; Sleep; Sleep Disorders, Circadian Rhythm

2016
Night workers with circadian misalignment are susceptible to alcohol-induced intestinal hyperpermeability with social drinking.
    American journal of physiology. Gastrointestinal and liver physiology, 2016, 07-01, Volume: 311, Issue:1

    Topics: Adult; Alcohol Drinking; Biomarkers; Circadian Rhythm; Circadian Rhythm Signaling Peptides and Prote

2016
Circadian Melatonin and Temperature Taus in Delayed Sleep-wake Phase Disorder and Non-24-hour Sleep-wake Rhythm Disorder Patients: An Ultradian Constant Routine Study.
    Journal of biological rhythms, 2016, Volume: 31, Issue:4

    Topics: Adult; Body Temperature; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Saliva; Sleep; Sl

2016
Estimating the dim light melatonin onset of adolescents within a 6-h sampling window: the impact of sampling rate and threshold method.
    Sleep medicine, 2016, Volume: 20

    Topics: Adolescent; Female; Humans; Light; Male; Melatonin; Saliva; Sleep Disorders, Circadian Rhythm; Speci

2016
Klokwerk + study protocol: An observational study to the effects of night-shift work on body weight and infection susceptibility and the mechanisms underlying these health effects.
    BMC public health, 2016, 08-02, Volume: 16

    Topics: Adolescent; Adult; Body Weight; Circadian Rhythm; Disease Susceptibility; Exercise; Health Personnel

2016
Acute effects of different light spectra on simulated night-shift work without circadian alignment.
    Chronobiology international, 2017, Volume: 34, Issue:3

    Topics: Adult; Attention; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Memory, Short-Term; Midd

2017
Sleep and circadian rhythm disturbance in bipolar disorder.
    Psychological medicine, 2017, Volume: 47, Issue:9

    Topics: Adult; Bipolar Disorder; Circadian Rhythm; Comorbidity; Female; Humans; Male; Melatonin; Middle Aged

2017
Melantonin for the treatment of advanced sleep phase disorder.
    Sleep, 2008, Volume: 31, Issue:7

    Topics: Central Nervous System Depressants; Drug Administration Schedule; Evidence-Based Medicine; Humans; M

2008
The impact of sleep timing and bright light exposure on attentional impairment during night work.
    Journal of biological rhythms, 2008, Volume: 23, Issue:4

    Topics: Adult; Biological Clocks; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Sleep; Sleep Dis

2008
Circadian rhythm disorders in pediatrics.
    Pediatric annals, 2008, Volume: 37, Issue:7

    Topics: Adolescent; Child; Circadian Rhythm; Genetic Predisposition to Disease; Health Behavior; Humans; Mal

2008
Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression.
    The American journal of psychiatry, 2008, Volume: 165, Issue:12

    Topics: Adult; Breast Feeding; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disor

2008
Interaction of chronic sleep restriction and circadian system in humans.
    Journal of sleep research, 2008, Volume: 17, Issue:4

    Topics: Adult; Chronic Disease; Female; Humans; Male; Melatonin; Sleep Deprivation; Sleep Disorders, Circadi

2008
Sleep length and quality, sleepiness and urinary melatonin among healthy Danish nurses with shift work during work and leisure time.
    International archives of occupational and environmental health, 2009, Volume: 82, Issue:10

    Topics: Adult; Denmark; Health Behavior; Humans; Leisure Activities; Melatonin; Middle Aged; Nurses; Personn

2009
Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders.
    Current opinion in investigational drugs (London, England : 2000), 2009, Volume: 10, Issue:7

    Topics: Animals; Benzofurans; Clinical Trials as Topic; Cyclopropanes; Drugs, Investigational; Humans; Melat

2009
Sleep timing and circadian phase in delayed sleep phase syndrome.
    Journal of biological rhythms, 2009, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Biomarkers; Body Temperature; Circadian Rhythm; Female; Humans; Male; Melatonin;

2009
Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma.
    Neurology, 2009, Jul-28, Volume: 73, Issue:4

    Topics: Adolescent; Age Factors; Biomarkers; Circadian Rhythm; Craniopharyngioma; Female; Humans; Hypopituit

2009
Depressive disorders may more commonly be related to circadian phase delays rather than advances: time will tell.
    Sleep medicine, 2010, Volume: 11, Issue:2

    Topics: Circadian Rhythm; Depressive Disorder; Humans; Melatonin; Sleep Disorders, Circadian Rhythm

2010
Sleep and rhythm consequences of a genetically induced loss of serotonin.
    Sleep, 2010, Volume: 33, Issue:3

    Topics: 5-Hydroxytryptophan; Adult; Alcohol Oxidoreductases; Antidepressive Agents, Second-Generation; Consa

2010
An unusual cause of insomnia following IED-induced traumatic brain injury.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010, Apr-15, Volume: 6, Issue:2

    Topics: Adult; Bombs; Brain Injuries; Central Nervous System Depressants; Depressive Disorder; Eye Injuries;

2010
Relationship between circadian salivary melatonin levels and sleep-wake behavior in infants.
    Pediatrics international : official journal of the Japan Pediatric Society, 2011, Volume: 53, Issue:1

    Topics: Age Factors; Biomarkers; Circadian Clocks; Environment; Female; Humans; Infant; Male; Melatonin; Sal

2011
Circadian melatonin profiles during single 24-h shifts in anesthetists.
    Sleep & breathing = Schlaf & Atmung, 2011, Volume: 15, Issue:3

    Topics: Adult; Anesthesiology; Austria; Circadian Rhythm; Humans; Lighting; Male; Melatonin; Operating Rooms

2011
Outcome of combined melatonin and bright light treatments for delayed sleep phase disorder.
    The Australian and New Zealand journal of psychiatry, 2010, Volume: 44, Issue:7

    Topics: Adolescent; Adult; Central Nervous System Depressants; Female; Humans; Male; Melatonin; Middle Aged;

2010
Effects of artificial dawn on subjective ratings of sleep inertia and dim light melatonin onset.
    Chronobiology international, 2010, Volume: 27, Issue:6

    Topics: Adult; Chronotherapy; Circadian Rhythm; Female; Humans; Male; Melatonin; Photoperiod; Phototherapy;

2010
[Burden and health effects of shift work].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2010, Volume: 45, Issue:10

    Topics: Circadian Rhythm; Disorders of Excessive Somnolence; Germany; Health; Humans; Melatonin; Occupationa

2010
Shedding light on the effectiveness of melatonin for circadian rhythm sleep disorders.
    Sleep, 2010, Volume: 33, Issue:12

    Topics: Central Nervous System Depressants; Humans; Melatonin; Sleep Disorders, Circadian Rhythm

2010
Sleep-wake cycles and cognitive functioning in schizophrenia.
    The British journal of psychiatry : the journal of mental science, 2011, Volume: 198, Issue:4

    Topics: Actigraphy; Adult; Circadian Rhythm; Cognition Disorders; Female; Humans; Male; Melatonin; Middle Ag

2011
Circadian rhythm sleep disorder, free-running type in a sighted male with severe depression, anxiety, and agoraphobia.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011, Feb-15, Volume: 7, Issue:1

    Topics: Aged; Agoraphobia; Anxiety Disorders; Combined Modality Therapy; Depressive Disorder; Disease Progre

2011
Circadian rhythm sleep disorders.
    The journal of the Royal College of Physicians of Edinburgh, 2011, Volume: 41, Issue:1

    Topics: Humans; Melatonin; Sleep Disorders, Circadian Rhythm; Sunlight

2011
Recognition and assessment of shift work disorder.
    The Journal of clinical psychiatry, 2011, Volume: 72, Issue:2

    Topics: Animals; Biological Clocks; Circadian Rhythm; Diabetes Mellitus, Type 2; Energy Metabolism; Hormones

2011
Free-running (non-entrained to 24-h period) circadian sleep disorder in a patient with obstructive sleep apnea, delayed sleep phase tendency, and lack of social interaction.
    Sleep & breathing = Schlaf & Atmung, 2012, Volume: 16, Issue:2

    Topics: Arousal; Circadian Rhythm; Comorbidity; Continuous Positive Airway Pressure; Disorders of Excessive

2012
Evaluation of salivary melatonin measurements for Dim Light Melatonin Onset calculations in patients with possible sleep-wake rhythm disorders.
    Clinica chimica acta; international journal of clinical chemistry, 2011, Aug-17, Volume: 412, Issue:17-18

    Topics: Adolescent; Adult; Child; Female; Humans; Male; Melatonin; Middle Aged; Radioimmunoassay; Saliva; Sl

2011
Abnormal circadian rhythm of melatonin in Smith-Magenis syndrome patients with RAI1 point mutations.
    American journal of medical genetics. Part A, 2011, Volume: 155A, Issue:8

    Topics: Adult; Child; Circadian Rhythm; Female; Genetic Association Studies; Humans; Male; Melatonin; Point

2011
Sleep and circadian rhythm disruption in schizophrenia.
    The British journal of psychiatry : the journal of mental science, 2012, Volume: 200, Issue:4

    Topics: Adult; Case-Control Studies; Female; Humans; Male; Melatonin; Monitoring, Ambulatory; Schizophrenia;

2012
Free-running disorder in a sighted adolescent.
    The Journal of pediatrics, 2012, Volume: 160, Issue:5

    Topics: Actigraphy; Child; Female; Follow-Up Studies; Humans; Melatonin; Risk Assessment; Severity of Illnes

2012
Altered circadian rhythm of melatonin concentrations in hypocretin-deficient men.
    Chronobiology international, 2012, Volume: 29, Issue:3

    Topics: Adult; Case-Control Studies; Circadian Rhythm; Humans; Intracellular Signaling Peptides and Proteins

2012
[The use of melatonin for correction of sleep disturbances in assembly-line shift workers with arterial hypertension].
    Klinicheskaia meditsina, 2012, Volume: 90, Issue:3

    Topics: Acrylates; Adult; Antihypertensive Agents; Circadian Clocks; Female; Humans; Hypertension; Imidazole

2012
[Internal clock desynchronization, light and melatonin].
    Bulletin de l'Academie nationale de medecine, 2011, Volume: 195, Issue:7

    Topics: Chronotherapy; Circadian Rhythm; Humans; Lighting; Melatonin; Sleep Disorders, Circadian Rhythm

2011
Circadian phase, sleepiness, and light exposure assessment in night workers with and without shift work disorder.
    Chronobiology international, 2012, Volume: 29, Issue:7

    Topics: Adult; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Middle Aged; Photoperiod; Saliva; S

2012
Melatonin profile and its relation to circadian rhythm sleep disorders in Angelman syndrome patients.
    Sleep medicine, 2012, Volume: 13, Issue:9

    Topics: Adolescent; Adult; Angelman Syndrome; Case-Control Studies; Child; Circadian Rhythm; Female; Humans;

2012
[Melatonin as a regulator of human sleep and circadian systems].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70, Issue:7

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Receptors, Melatonin; Sleep; Sleep Disorders, Circadian

2012
Circadian rhythm sleep disorders.
    Neurologic clinics, 2012, Volume: 30, Issue:4

    Topics: Adolescent; Circadian Rhythm; Humans; Male; Melatonin; Sleep Disorders, Circadian Rhythm; Treatment

2012
Light-at-night-induced circadian disruption, cancer and aging.
    Current aging science, 2012, Volume: 5, Issue:3

    Topics: Age Factors; Aging; Animals; Anticarcinogenic Agents; Blindness; Cell Transformation, Neoplastic; Ci

2012
Objective measures of sleep and dim light melatonin onset in adolescents and young adults with delayed sleep phase disorder compared to healthy controls.
    Journal of sleep research, 2013, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Case-Control Studies; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; P

2013
Human circadian phase in 12:12 h, 200: <8 lux and 1000: <8 lux light-dark cycles, without scheduled sleep or activity.
    Neuroscience letters, 2002, Aug-23, Volume: 329, Issue:1

    Topics: Adolescent; Adult; Arousal; Body Temperature; Circadian Rhythm; Darkness; Humans; Lighting; Male; Me

2002
Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteers.
    Chronobiology international, 2002, Volume: 19, Issue:5

    Topics: Aged; Circadian Rhythm; Depression; Female; Humans; Light; Male; Melatonin; Middle Aged; Phototherap

2002
Case study of circadian rhythm sleep disorder following haloperidol treatment: reversal by risperidone and melatonin.
    Chronobiology international, 2002, Volume: 19, Issue:5

    Topics: Adult; Antipsychotic Agents; Chronotherapy; Circadian Rhythm; Haloperidol; Humans; Male; Melatonin;

2002
Transient total sleep loss in cerebral Whipple's disease: a longitudinal study.
    Journal of sleep research, 2002, Volume: 11, Issue:4

    Topics: Adult; Brain; Carrier Proteins; Circadian Rhythm; Electroencephalography; Fixation, Ocular; Fluorode

2002
[Sleep-wake rhythm disorders].
    No to shinkei = Brain and nerve, 2003, Volume: 55, Issue:1

    Topics: Humans; Jet Lag Syndrome; Melatonin; Phototherapy; Sleep; Sleep Disorders, Circadian Rhythm; Sleep S

2003
[Brain and education].
    No to hattatsu = Brain and development, 2003, Volume: 35, Issue:2

    Topics: Adolescent; Body Temperature Regulation; Brain; Child; Child, Preschool; Circadian Rhythm; Humans; J

2003
Non-24-hour sleep-wake syndrome following a car accident.
    Neurology, 2003, Jun-10, Volume: 60, Issue:11

    Topics: Accidents, Traffic; Adult; Circadian Rhythm; Craniocerebral Trauma; Female; Humans; Melatonin; Sleep

2003
[The effects of electrostimulation upon soldier's circadian of melatonin in plasma].
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2003, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Chronobiology Disorders; Circadian Rhythm; Electric Stimulation; Humans; Male; Me

2003
Point and interval estimations of circadian melatonin ecphasia in Smith-Magenis syndrome.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2003, Volume: 57 Suppl 1

    Topics: Adolescent; Adult; Child; Chromosome Deletion; Chromosomes, Human, Pair 17; Congenital Abnormalities

2003
Measuring and identifying large-study metrics for circadian rhythm disruption in female flight attendants.
    Scandinavian journal of work, environment & health, 2003, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aerospace Medicine; Circadian Rhythm; Factor Analysis, Statistical; Female; Human

2003
Restless nights, listless days.
    Nature, 2003, Oct-30, Volume: 425, Issue:6961

    Topics: Adolescent; Adult; Aged; Aging; Alzheimer Disease; Biological Clocks; Circadian Rhythm; Darkness; Hu

2003
Suppression of sleepiness and melatonin by bright light exposure during breaks in night work.
    Journal of sleep research, 2004, Volume: 13, Issue:1

    Topics: Adaptation, Physiological; Adult; Circadian Rhythm; Disorders of Excessive Somnolence; Employment; F

2004
[Health problems due to night shift work and jetlag].
    Der Internist, 2004, Volume: 45, Issue:9

    Topics: Accidents, Occupational; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Cross-Section

2004
The 24-h growth hormone rhythm in men: sleep and circadian influences questioned.
    Journal of sleep research, 2004, Volume: 13, Issue:3

    Topics: Adaptation, Physiological; Adult; Circadian Rhythm; Growth Hormone; Habituation, Psychophysiologic;

2004
Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work.
    Sleep, 2004, Sep-15, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Arousal; Body Temperature; Circadian Rhythm; Cognition Disorders; Disorders of Ex

2004
Changes in the concentration of urinary 6-sulphatoxymelatonin during a week of simulated night work.
    Industrial health, 2005, Volume: 43, Issue:1

    Topics: Adaptation, Physiological; Adult; Female; Humans; Male; Melatonin; Personnel Staffing and Scheduling

2005
Dysregulation of circadian rhythms following prolactin-secreting pituitary microadenoma.
    Chronobiology international, 2005, Volume: 22, Issue:1

    Topics: Adenoma; Adult; Body Temperature; Circadian Rhythm; Humans; Male; Melatonin; Photoperiod; Pituitary

2005
Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder.
    Chronobiology international, 2005, Volume: 22, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Data Interpretation, Statistical; Environmenta

2005
Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder?
    Chronobiology international, 2005, Volume: 22, Issue:3

    Topics: Biological Clocks; Circadian Rhythm; Humans; Light; Lighting; Male; Melatonin; Middle Aged; Photothe

2005
Sleep tendency during extended wakefulness: insights into adolescent sleep regulation and behavior.
    Journal of sleep research, 2005, Volume: 14, Issue:3

    Topics: Adolescent; Adolescent Behavior; Child; Circadian Rhythm; Electromyography; Female; Homeostasis; Hum

2005
Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion.
    Spinal cord, 2006, Volume: 44, Issue:2

    Topics: Adolescent; Adult; Case-Control Studies; Cervical Vertebrae; Child; Child, Preschool; Female; Humans

2006
The treatment of early-morning awakening insomnia with 2 evenings of bright light.
    Sleep, 2005, Volume: 28, Issue:5

    Topics: Adult; Aged; Body Temperature; Female; Follow-Up Studies; Humans; Male; Melatonin; Middle Aged; Phot

2005
Case study: psychiatric misdiagnosis of non-24-hours sleep-wake schedule disorder resolved by melatonin.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:12

    Topics: Adolescent; Depressive Disorder; Diagnostic Errors; Disorders of Excessive Somnolence; Humans; Learn

2005
Timed melatonin treatment for delayed sleep phase syndrome: the importance of knowing circadian phase.
    Sleep, 2005, Volume: 28, Issue:10

    Topics: Antioxidants; Chronobiology Disorders; Chronobiology Phenomena; Cognition; Drug Administration Sched

2005
Impairment of the melatonin rhythm in children with Sanfilippo syndrome.
    Journal of pineal research, 2006, Volume: 40, Issue:2

    Topics: Adolescent; Child; Circadian Rhythm; Female; Humans; Male; Melatonin; Mucopolysaccharidosis III; Sle

2006
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
    Sleep, 2006, Volume: 29, Issue:2

    Topics: Adult; Arousal; Disorders of Excessive Somnolence; Electroencephalography; Female; Humans; Hydrocort

2006
A compromise phase position for permanent night shift workers: circadian phase after two night shifts with scheduled sleep and light/dark exposure.
    Chronobiology international, 2006, Volume: 23, Issue:4

    Topics: Adult; Biological Clocks; Body Temperature; Circadian Rhythm; Darkness; Female; Humans; Light; Male;

2006
Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin.
    The Journal of pediatrics, 2006, Volume: 149, Issue:3

    Topics: Acebutolol; Adrenergic beta-Antagonists; Antioxidants; Child, Preschool; Chromosome Deletion; Chromo

2006
Circadian phase in delayed sleep phase syndrome: predictors and temporal stability across multiple assessments.
    Sleep, 2006, Volume: 29, Issue:8

    Topics: Adult; Circadian Rhythm; Female; Humans; Lighting; Male; Melatonin; Reference Values; Saliva; Sleep

2006
Melatonin treatment in adolescents with delayed sleep phase syndrome.
    Clinical pediatrics, 2006, Volume: 45, Issue:9

    Topics: Administration, Oral; Adolescent; Age Factors; Analysis of Variance; Attention Deficit Disorder with

2006
Melatonin and sleep disorders: no better than placebo.
    Prescrire international, 2006, Volume: 15, Issue:86

    Topics: Humans; Melatonin; Meta-Analysis as Topic; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders

2006
Estimating dim light melatonin onset (DLMO) phase in adolescents using summer or school-year sleep/wake schedules.
    Sleep, 2006, Volume: 29, Issue:12

    Topics: Adolescent; Child; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Saliva; Seasons; Sleep

2006
Endogenous melatonin predicts efficacy of exogenous melatonin in consolidation of fragmented wrist-activity rhythm of adult patients with developmental brain disorders: a double-blind, placebo-controlled, crossover study.
    Sleep medicine, 2007, Volume: 8, Issue:3

    Topics: Adult; Circadian Rhythm; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method;

2007
Melatonin treatment efficacy: for whom and for what?
    Sleep medicine, 2007, Volume: 8, Issue:3

    Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Melatonin; Polysomnog

2007
Circadian rhythm sleep disorders following mild traumatic brain injury.
    Neurology, 2007, Apr-03, Volume: 68, Issue:14

    Topics: Adolescent; Adult; Body Temperature; Brain Injuries; Circadian Rhythm; Female; Humans; Male; Melaton

2007
Constant light housing during nursing causes human DSPS (delayed sleep phase syndrome) behaviour in Clock-mutant mice.
    The European journal of neuroscience, 2007, Volume: 25, Issue:8

    Topics: Animals; Behavior, Animal; Circadian Rhythm; CLOCK Proteins; Female; Humans; Lactation; Light; Melat

2007
Sleep disturbance of residents in a continuing care retirement community.
    Journal of gerontological nursing, 2007, Volume: 33, Issue:10

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Body Temperature; Geriatric Assessment; Geriatric Nur

2007
Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:2

    Topics: Adult; Body Temperature; Body Temperature Regulation; Circadian Rhythm; Female; Humans; Jet Lag Synd

2008
Circadian phase in sleep-disturbed adolescents with a history of substance abuse: a pilot study.
    Behavioral sleep medicine, 2008, Volume: 6, Issue:1

    Topics: Adolescent; Documentation; Female; Humans; Male; Melatonin; Personality Inventory; Pilot Projects; P

2008
The use of melatonin to treat sleep disorder in adults with intellectual disabilities in community settings - the evaluation of three cases using actigraphy.
    Journal of intellectual disability research : JIDR, 2008, Volume: 52, Issue:Pt 6

    Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hu

2008
Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blind.
    Journal of sleep research, 2008, Volume: 17, Issue:2

    Topics: Adult; Affect; Aged; Arousal; Attention; Blindness; Choice Behavior; Circadian Rhythm; Female; Human

2008
Association between melatonin secretion and daytime sleep complaints in night nurses.
    Sleep, 1999, Nov-01, Volume: 22, Issue:7

    Topics: Adult; Female; Humans; Male; Melatonin; Middle Aged; Nurses; Radioimmunoassay; Severity of Illness I

1999
Circadian disturbances after night-shift work onboard a naval ship.
    Military medicine, 2000, Volume: 165, Issue:2

    Topics: Adult; Case-Control Studies; Humans; Hydrocortisone; Male; Melatonin; Military Personnel; Naval Medi

2000
Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome.
    Journal of psychosomatic research, 2000, Volume: 48, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Chronic Disease; Female; Follow-Up

2000
Poor compensatory function for sleep loss as a pathogenic factor in patients with delayed sleep phase syndrome.
    Sleep, 2000, Jun-15, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Body Temperature; Female; Humans; Male; Melatonin; Severity of Illness Index; Sle

2000
Altered circadian rhythms of the stress hormone and melatonin response in lupus-prone MRL/MP-fas(Ipr) mice.
    Journal of autoimmunity, 2000, Volume: 14, Issue:4

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Dehydroepiandrosterone Sulfate

2000
[Melatonin in sleep rhythm disorders after cerebral stroke].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000, Volume: 8, Issue:48

    Topics: Aged; Aged, 80 and over; Antioxidants; Female; Humans; Male; Melatonin; Middle Aged; Sleep Disorders

2000
Melatonin improves sleep-wake patterns in psychomotor retarded children.
    Pediatric neurology, 2000, Volume: 23, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Intellectual Disability; Male

2000
Melatonin for the treatment of handicapped children with severe sleep disorders.
    Pediatric neurology, 2000, Volume: 23, Issue:3

    Topics: Child; Child, Preschool; Circadian Rhythm; Disabled Children; Drug Administration Schedule; Female;

2000
Sleep-wake as a biological rhythm.
    Annual review of psychology, 2001, Volume: 52

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Sleep Deprivation; Sleep Disorders, Circadian Rhythm

2001
Therapeutic progress of two sibling cases exhibiting sleep-wake rhythm disorder.
    Psychiatry and clinical neurosciences, 2000, Volume: 54, Issue:3

    Topics: Adolescent; Female; Humans; Melatonin; Polysomnography; Sleep Deprivation; Sleep Disorders, Circadia

2000
Melatonin treatment for circadian rhythm sleep disorders.
    Psychiatry and clinical neurosciences, 2000, Volume: 54, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Dose-Response Relationship, Drug; Drug Administration Sched

2000
Case of a mentally retarded child with non-24 hour sleep-wake syndrome caused by deficiency of melatonin secretion.
    Psychiatry and clinical neurosciences, 2000, Volume: 54, Issue:3

    Topics: Administration, Oral; Child, Preschool; Humans; Hydrocortisone; Intellectual Disability; Male; Melat

2000
Effect of melatonin on sleep-wake rhythm: the sleep diary of an autistic male.
    Psychiatry and clinical neurosciences, 2000, Volume: 54, Issue:3

    Topics: Adolescent; Autistic Disorder; Circadian Rhythm; Drug Administration Schedule; Humans; Male; Melaton

2000
Familial advanced sleep phase syndrome.
    Archives of neurology, 2001, Volume: 58, Issue:7

    Topics: Adult; Aged; Female; Humans; Light; Male; Melatonin; Middle Aged; Pedigree; Phenotype; Sleep Disorde

2001
Arrhythmicity in a child with septo-optic dysplasia and establishment of sleep-wake cyclicity with melatonin.
    The Journal of pediatrics, 2001, Volume: 139, Issue:3

    Topics: Child, Preschool; Female; Free Radical Scavengers; Humans; Melatonin; Sleep Disorders, Circadian Rhy

2001
Circadian abnormalities in older adults.
    Journal of pineal research, 2001, Volume: 31, Issue:3

    Topics: Adult; Aged; Aging; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Polysomnograp

2001
Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin.
    Brain research, 2001, Nov-09, Volume: 918, Issue:1-2

    Topics: Adult; Biological Clocks; Blindness; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Admini

2001
Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin.
    Brain research, 2001, Nov-09, Volume: 918, Issue:1-2

    Topics: Adult; Biological Clocks; Blindness; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Admini

2001
Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin.
    Brain research, 2001, Nov-09, Volume: 918, Issue:1-2

    Topics: Adult; Biological Clocks; Blindness; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Admini

2001
Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin.
    Brain research, 2001, Nov-09, Volume: 918, Issue:1-2

    Topics: Adult; Biological Clocks; Blindness; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Admini

2001
The start of the quiescent period of cortisol remains phase locked to the melatonin onset despite circadian phase alterations in humans working the night schedule.
    Neuroscience letters, 2002, Jan-25, Volume: 318, Issue:2

    Topics: Adaptation, Physiological; Circadian Rhythm; Humans; Hydrocortisone; Male; Melatonin; Sleep Disorder

2002
Larger phase angle between sleep propensity and melatonin rhythms in sighted humans with non-24-hour sleep-wake syndrome.
    Sleep, 2002, Feb-01, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Case-Control Studies; Circadian Rhythm; Female; Humans; Male; Melatonin; Polysomn

2002
Sleep- and circadian-dependent modulation of REM density.
    Journal of sleep research, 2002, Volume: 11, Issue:1

    Topics: Adult; Electroencephalography; Electromyography; Facial Muscles; Humans; Male; Melatonin; Sleep Diso

2002
[Melatonin and circadian rhythm].
    Revue neurologique, 2001, Volume: 157, Issue:11 Pt 2

    Topics: Circadian Rhythm; Humans; Melatonin; Sleep Disorders, Circadian Rhythm; Sleep Stages; Wakefulness

2001
[Advanced sleep phase syndrome].
    Revue neurologique, 2001, Volume: 157, Issue:11 Pt 2

    Topics: Adolescent; Adult; Aged; Chronotherapy; Female; Humans; Hydrocortisone; Male; Melatonin; Middle Aged

2001
Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period.
    Chronobiology international, 2002, Volume: 19, Issue:3

    Topics: Administration, Oral; Blindness; Circadian Rhythm; Dose-Response Relationship, Drug; Humans; Male; M

2002
[Melatonin treatment of a blind child with serious sleep disorders].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2002, Apr-20, Volume: 122, Issue:10

    Topics: Blindness; Child, Preschool; Chronic Disease; Developmental Disabilities; Humans; Male; Melatonin; P

2002