melatonin has been researched along with Sleep Apnea, Obstructive in 29 studies
Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia." | 7.81 | Melatonin prevents hyperglycemia in a model of sleep apnea. ( Fagundes, M; Fiori, CZ; Kaminski, RS; Marroni, NP; Martinez, D; Martins, EF; Montanari, CC; Rosa, DP, 2015) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 5.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia." | 3.81 | Melatonin prevents hyperglycemia in a model of sleep apnea. ( Fagundes, M; Fiori, CZ; Kaminski, RS; Marroni, NP; Martinez, D; Martins, EF; Montanari, CC; Rosa, DP, 2015) |
| "Seventeen male patients with severe obstructive sleep apnea syndrome (OSAS; apnea-hypopnea index>30/h) were monitored by polysomnography in the sleep lab before and after about 8 weeks of continuous positive airway pressure (CPAP)." | 2.82 | Circadian rhythms in blood pressure, heart rate, hormones, and on polysomnographic parameters in severe obstructive sleep apnea syndrome patients: effect of continuous positive airway pressure. ( Lemmer, B; Schmitt, J; Scholtze, J, 2016) |
| "Melatonin is a pineal hormone that regulates the human cycle of sleep and wakefulness." | 2.73 | Nocturnal melatonin plasma levels in patients with OSAS: the effect of CPAP. ( Abreu, J; Abreu, P; Castro, A; Hernández, C; Jiménez, A, 2007) |
| "Obstructive sleep apnea is the most prevalent type of obesity-related sleep disorder that lead to an increased risk for numerous chronic health conditions." | 2.61 | Obesity and sleep disturbance: the chicken or the egg? ( Annunziata, G; Barrea, L; Colao, A; Di Somma, C; Laudisio, D; Muscogiuri, G; Savastano, S, 2019) |
| "The consequences of insomnia, including issues with mood, behavior, and cognition, are discussed." | 2.53 | Pediatric Insomnia. ( Brown, KM; Malow, BA, 2016) |
| "The literature describes sleep disorders as common in both conditions." | 2.48 | Interventions with a sleep outcome for children with cerebral palsy or a post-traumatic brain injury: a systematic review. ( Elder, DE; Galland, BC; Taylor, BJ, 2012) |
| "Most is known about obstructive sleep apnea syndrome (OSAS)." | 2.47 | Sleep disturbances in people with epilepsy; prevalence, impact and treatment. ( de Weerd, AW; Gutter, T; van Golde, EG, 2011) |
| "As diabetic retinopathy may affect melatonin secretion, we also explore the relationship between retinopathy, melatonin and glycemic control." | 1.46 | Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes. ( Chailurkit, LO; Chirakalwasan, N; Nimitphong, H; Ongphiphadhanakul, B; Reutrakul, S; Saetung, S; Siwasaranond, N; Srijaruskul, K; Thakkinstian, A, 2017) |
| "Melatonin has a known influence on the sleep and wake rhythm." | 1.39 | Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome? ( Brzozowski, T; Fuchs, FS; Hildner, KM; Konturek, PC; Neurath, MF; Targosz, A; Zirlik, S, 2013) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 1.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "Effective treatments now exist for many sleep disorders, such as OSA and RLS, and a major breakthrough in the treatment of narcolepsy seems imminent." | 1.32 | Sleep disorders. ( Fisch, BJ; Olejniczak, PW, 2003) |
| "Melatonin is a pineal hormone that regulates sleep and wake status." | 1.31 | [Rhythm of melatonin excretion in obstructive sleep apnea syndrome]. ( Brzecka, A; Piesiak, P; Plamieniak, Z; Zareba-Bogdał, E; Zierkiewicz, G, 2001) |
| "A hypnic headache was captured in one patient arising out of rapid eye movement sleep at a time of severe oxygen desaturation." | 1.31 | Polysomnography in hypnic headache syndrome. ( Dodick, DW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Bazin, B | 1 |
| Geoffroy, PA | 1 |
| Benzaquen, H | 1 |
| Maruani, J | 1 |
| Romier, A | 1 |
| Lejoyeux, M | 1 |
| D'ortho, MP | 1 |
| Frija-Masson, J | 1 |
| Butler, MP | 2 |
| Thosar, SS | 1 |
| Smales, C | 2 |
| DeYoung, PN | 1 |
| Wu, H | 2 |
| Hussain, MV | 2 |
| Morimoto, M | 2 |
| Hu, K | 1 |
| Scheer, FAJL | 1 |
| Shea, SA | 2 |
| Miller, MA | 1 |
| Cappuccio, FP | 1 |
| Gaspar, LS | 1 |
| Hesse, J | 1 |
| Yalçin, M | 1 |
| Santos, B | 1 |
| Carvalhas-Almeida, C | 1 |
| Ferreira, M | 1 |
| Moita, J | 1 |
| Relógio, A | 1 |
| Cavadas, C | 1 |
| Álvaro, AR | 1 |
| Schaefer, C | 1 |
| Kunz, D | 1 |
| Bes, F | 1 |
| Barnaś, M | 1 |
| Maskey-Warzęchowska, M | 1 |
| Bielicki, P | 1 |
| Kumor, M | 1 |
| Chazan, R | 1 |
| Muscogiuri, G | 1 |
| Barrea, L | 1 |
| Annunziata, G | 1 |
| Di Somma, C | 1 |
| Laudisio, D | 1 |
| Colao, A | 1 |
| Savastano, S | 1 |
| Zirlik, S | 1 |
| Hildner, KM | 1 |
| Targosz, A | 1 |
| Neurath, MF | 1 |
| Fuchs, FS | 1 |
| Brzozowski, T | 1 |
| Konturek, PC | 1 |
| Yeung, HM | 1 |
| Hung, MW | 1 |
| Lau, CF | 1 |
| Fung, ML | 1 |
| Kaminski, RS | 1 |
| Martinez, D | 1 |
| Fagundes, M | 1 |
| Martins, EF | 1 |
| Montanari, CC | 1 |
| Rosa, DP | 1 |
| Fiori, CZ | 1 |
| Marroni, NP | 1 |
| Mohamed, YA | 1 |
| Xie, S | 1 |
| Deng, Y | 1 |
| Pan, YY | 1 |
| Wang, ZH | 1 |
| Ren, J | 1 |
| Guo, XL | 1 |
| Yuan, X | 1 |
| Shang, J | 1 |
| Liu, HG | 1 |
| Brown, KM | 1 |
| Malow, BA | 1 |
| Lemmer, B | 1 |
| Scholtze, J | 1 |
| Schmitt, J | 1 |
| Reutrakul, S | 1 |
| Siwasaranond, N | 1 |
| Nimitphong, H | 1 |
| Saetung, S | 1 |
| Chirakalwasan, N | 1 |
| Chailurkit, LO | 1 |
| Srijaruskul, K | 1 |
| Ongphiphadhanakul, B | 1 |
| Thakkinstian, A | 1 |
| Bradley, AJ | 1 |
| Webb-Mitchell, R | 1 |
| Hazu, A | 1 |
| Slater, N | 1 |
| Middleton, B | 1 |
| Gallagher, P | 1 |
| McAllister-Williams, H | 1 |
| Anderson, KN | 1 |
| Bertuglia, S | 1 |
| Reiter, RJ | 1 |
| van Golde, EG | 1 |
| Gutter, T | 1 |
| de Weerd, AW | 1 |
| Kuźniar, TJ | 1 |
| Kovačević-Ristanović, R | 1 |
| Nierodzik, CL | 1 |
| Smith, LC | 1 |
| Papaioannou, I | 1 |
| Twigg, GL | 1 |
| Kemp, M | 1 |
| Roughton, M | 1 |
| Hooper, J | 1 |
| Morrell, MJ | 1 |
| Polkey, MI | 1 |
| Venkateshiah, SB | 1 |
| Collop, NA | 1 |
| Galland, BC | 1 |
| Elder, DE | 1 |
| Taylor, BJ | 1 |
| Heussler, H | 1 |
| Chan, P | 1 |
| Price, AM | 1 |
| Waters, K | 1 |
| Davey, MJ | 1 |
| Hiscock, H | 1 |
| Brzecka, A | 1 |
| Piesiak, P | 1 |
| Zareba-Bogdał, E | 1 |
| Zierkiewicz, G | 1 |
| Plamieniak, Z | 1 |
| Olejniczak, PW | 1 |
| Fisch, BJ | 1 |
| Jordan, W | 1 |
| Cohrs, S | 1 |
| Degner, D | 1 |
| Meier, A | 1 |
| Rodenbeck, A | 1 |
| Mayer, G | 1 |
| Pilz, J | 1 |
| Rüther, E | 1 |
| Kornhuber, J | 1 |
| Bleich, S | 1 |
| Hernández, C | 1 |
| Abreu, J | 1 |
| Abreu, P | 1 |
| Castro, A | 1 |
| Jiménez, A | 1 |
| Dodick, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Obstructive Sleep Apnea in Patients With Long COVID-19 Fatigue: a Multicentre Prospective Cohort Study[NCT05290350] | 300 participants (Anticipated) | Observational | 2022-03-10 | Recruiting | |||
| Prevalence of Epilepsy and Sleep Wake Disorders in Alzheimer Disease[NCT03617497] | 78 participants (Actual) | Interventional | 2020-12-01 | Active, not recruiting | |||
| Circadian Health in Patients Admitted to Intensive Care Units and Hospitalization (CHRONOHOSPI)[NCT04113876] | 975 participants (Actual) | Observational [Patient Registry] | 2019-01-01 | Completed | |||
| Follow-up Studies of PS and OSAHS in Chinese Children[NCT02447614] | 500 participants (Actual) | Observational [Patient Registry] | 2014-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for melatonin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
A systematic review of COVID-19 and obstructive sleep apnoea.
Topics: Comorbidity; Continuous Positive Airway Pressure; COVID-19; Diabetes Mellitus; Humans; Hypertension; | 2021 |
Obesity and sleep disturbance: the chicken or the egg?
Topics: Diet; Endocannabinoids; Energy Metabolism; Exercise; Ghrelin; Humans; Hydrocortisone; Leptin; Melato | 2019 |
Pediatric Insomnia.
Topics: Actigraphy; Adolescent; Amines; Anti-Anxiety Agents; Autism Spectrum Disorder; Central Nervous Syste | 2016 |
Sleep disturbances in people with epilepsy; prevalence, impact and treatment.
Topics: Adolescent; Adult; Central Nervous System Depressants; Child; Epilepsy; Female; Humans; Male; Melato | 2011 |
Interventions with a sleep outcome for children with cerebral palsy or a post-traumatic brain injury: a systematic review.
Topics: Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Humans; Hypnotics and Sedatives; Infant; Me | 2012 |
3 trials available for melatonin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Circadian rhythms in blood pressure, heart rate, hormones, and on polysomnographic parameters in severe obstructive sleep apnea syndrome patients: effect of continuous positive airway pressure.
Topics: Adult; Aged; Blood Pressure; Circadian Rhythm; Continuous Positive Airway Pressure; Heart Rate; Huma | 2016 |
Nocturnal melatonin plasma levels in patients with OSAS: the effect of CPAP.
Topics: Adult; Circadian Rhythm; Continuous Positive Airway Pressure; Female; Humans; Male; Melatonin; Middl | 2007 |
21 other studies available for melatonin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Continuous positive airway pressure as an accurate marker for non-24-hour sleep-wake rhythm disorder.
Topics: Autism Spectrum Disorder; Circadian Rhythm; Continuous Positive Airway Pressure; Humans; Male; Melat | 2023 |
Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis.
Topics: Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Apnea, Obstructive; Sleep Disorders, Circadian Rhy | 2020 |
Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea.
Topics: ARNTL Transcription Factors; Biological Clocks; Body Temperature; Case-Control Studies; CLOCK Protei | 2021 |
Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A Case Series.
Topics: Aged; Humans; Hypnotics and Sedatives; Male; Melatonin; Polysomnography; REM Sleep Behavior Disorder | 2017 |
Diurnal and nocturnal serum melatonin concentrations after treatment with continuous positive airway pressure in patients with obstructive sleep apnea.
Topics: Adult; Aged; Circadian Rhythm; Continuous Positive Airway Pressure; Female; Humans; Male; Melatonin; | 2017 |
Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome?
Topics: Biomarkers; Body Mass Index; Circadian Rhythm; Continuous Positive Airway Pressure; Cytokines; Down- | 2013 |
Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats.
Topics: Animals; Antioxidants; Biomarkers; Cardiotonic Agents; Chronic Disease; Cytokines; Gene Expression R | 2015 |
Melatonin prevents hyperglycemia in a model of sleep apnea.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Disease Models, Anim | 2015 |
The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea.
Topics: Adult; Aged; Circadian Rhythm; Darkness; Female; Humans; Light; Male; Melatonin; Middle Aged; Monito | 2015 |
Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5' adenosine monophosphate-activated protein kinase pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cardiomegaly; Cardiotonic Agents; Cell Line; Chro | 2015 |
Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Circadian Rhythm; Creatinine; Diabetes Mellitus, Type 2; Diabetic Retino | 2017 |
Sleep and circadian rhythm disturbance in bipolar disorder.
Topics: Adult; Bipolar Disorder; Circadian Rhythm; Comorbidity; Female; Humans; Male; Melatonin; Middle Aged | 2017 |
Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia.
Topics: Analysis of Variance; Animals; Blood Glucose; Cricetinae; Glucose Clamp Technique; Hemodynamics; Hyp | 2009 |
Free-running (non-entrained to 24-h period) circadian sleep disorder in a patient with obstructive sleep apnea, delayed sleep phase tendency, and lack of social interaction.
Topics: Arousal; Circadian Rhythm; Comorbidity; Continuous Positive Airway Pressure; Disorders of Excessive | 2012 |
Melatonin concentration as a marker of the circadian phase in patients with obstructive sleep apnoea.
Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Lighting; Male; Melatonin; Middle Aged; Polysom | 2012 |
Sleep and sleep disorders in the hospital.
Topics: Circadian Rhythm; Hospitalization; Humans; Melatonin; Polysomnography; Respiration, Artificial; Slee | 2012 |
Pharmacological and non-pharmacological management of sleep disturbance in children: an Australian Paediatric Research Network survey.
Topics: Adult; Aged; Anxiety Disorders; Australia; Behavior Therapy; Child; Clonidine; Comorbidity; Dose-Res | 2013 |
[Rhythm of melatonin excretion in obstructive sleep apnea syndrome].
Topics: Adult; Circadian Rhythm; Humans; Male; Melatonin; Middle Aged; Sleep Apnea, Obstructive; Sleep Stage | 2001 |
Sleep disorders.
Topics: Adult; Aged; Antioxidants; Cheyne-Stokes Respiration; Chronobiology Disorders; Chronotherapy; Disord | 2003 |
Evaluation of oxidative stress measurements in obstructive sleep apnea syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Antioxidants; Biomarkers; Continuous Positive Airway Press | 2006 |
Polysomnography in hypnic headache syndrome.
Topics: Aged; Female; Headache; Humans; Indomethacin; Male; Melatonin; Middle Aged; Polysomnography; Recurre | 2000 |