melatonin and Skin Aging studies

Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.

Research Excerpts

Excerpt	Relevance	Reference
"To study the association between serum melatonin levels and skin aging grades among people aged 20-69 years in Ulaanbaatar city."	7.96	Association between serum melatonin and skin aging in an urban population of Mongolia. ( Byamba, K; Dorjkhuu, A; Myatav, T; Nanzadsuren, T, 2020)
"Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development of effective skin senotherapeutics."	5.91	Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo. ( Akhundlu, A; Chéret, J; Gherardini, J; Gomez-Gomez, T; Gompels, M; Lee, WW; Linowiecka, K; Lopez de Mendoza, G; Paus, R; Samra, T, 2023)
"In two previous communications to the RANM four and two years ago, some data were shown supporting the role of GH, Melatonin and Estrogens in the prevention of aging in a group of physiological parameters including bone, liver metabolism and vascular activity, the Central nervous System (CNS,) the immune system and the skin."	3.73	[Molecular mechanisms of aging and its prevention by hormonal treatment in rats]. ( Fernández-Tresguerres Hernández, JA, 2006)
"Melatonin is an endogenous hormone commonly associated with regulation of sleep."	2.58	Assessing the Potential Role for Topical Melatonin in an Antiaging Skin Regimen. ( Burgess, CM; Day, D; Kircik, LH, 2018)
"Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development of effective skin senotherapeutics."	1.91	Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo. ( Akhundlu, A; Chéret, J; Gherardini, J; Gomez-Gomez, T; Gompels, M; Lee, WW; Linowiecka, K; Lopez de Mendoza, G; Paus, R; Samra, T, 2023)
"Transdermal drug delivery system is a preferable choice to overcome the low bioavailability of oral medication."	1.72	Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice. ( Cong, Y; Hao, J; Hou, X; Qiu, X; Song, S; Wang, Y, 2022)
"Melatonin oral treatment significantly reversed the increased serum LPO level in former-smokers already after 2 weeks of treatment."	1.46	Melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers - A study in postmenopausal women. ( Gesing, A; Karbownik-Lewinska, M; Lewinski, A; Sagan, D; Stepniak, J, 2017)
"Intrinsic skin aging is determined primarily by genetic factors and hormonal status."	1.32	[Intrinsic skin aging. A critical appraisal of the role of hormones]. ( Zouboulis, ChC, 2003)

Research

Studies (18)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Lip Vessel's Thickness

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (22.22)	29.6817
2010's	6 (33.33)	24.3611
2020's	8 (44.44)	2.80

Authors	Studies
Bocheva, G	1
Slominski, RM	1
Janjetovic, Z	2
Kim, TK	2
Böhm, M	1
Steinbrink, K	1
Reiter, RJ	2
Kleszczyński, K	2
Slominski, AT	2
Hou, X	1
Qiu, X	1
Wang, Y	1
Song, S	1
Cong, Y	1
Hao, J	1
Samra, T	1
Gomez-Gomez, T	1
Linowiecka, K	1
Akhundlu, A	1
Lopez de Mendoza, G	1
Gompels, M	1
Lee, WW	1
Gherardini, J	1
Chéret, J	1
Paus, R	1
Nanzadsuren, T	1
Myatav, T	1
Dorjkhuu, A	1
Byamba, K	1
Semak, I	1
Sweatman, T	1
Skobowiat, C	1
Steketee, JD	1
Lin, Z	1
Postlethwaite, A	1
Li, W	1
Tobin, DJ	1
Goldberg, DJ	2
Mraz-Robinson, D	1
Granger, C	2
Marchena, AM	1
Franco, L	1
Romero, AM	1
Barriga, C	1
Rodríguez, AB	1
Lee, AY	1
Sagan, D	1
Stepniak, J	1
Gesing, A	1
Lewinski, A	1
Karbownik-Lewinska, M	1
Park, EK	1
Lee, HJ	1
Lee, H	1
Kim, JH	1
Hwang, J	1
Koo, JI	1
Kim, SH	1
Day, D	1
Burgess, CM	1
Kircik, LH	1
Robinson, DM	1
Delalle-Lozica, N	1
Morganti, P	1
Fabrizi, G	1
Palombo, P	1
Palombo, M	1
Guarneri, F	1
Cardillo, A	1
Morganti, G	1
Zouboulis, ChC	1
Eşrefoğlu, M	1
Gül, M	1
Seyhan, M	1
Parlakpinar, H	1
Fernández-Tresguerres Hernández, JA	1
Fischer, TW	1
Elsner, P	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Assessment and Augmentation of Lip Appearance in Specific Study Populations[NCT04839692]	Phase 4	37 participants (Actual)	Interventional	2021-05-07	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Pre and post-treatment lip vessel thickness was measured in µm using Optical Coherence Tomography-Angiography imaging. For each age group, pre and post-treatment means were calculated.~The difference between the post and the pre-treatment means is shown below (post-treatment mean - pre-treatment mean)." (NCT04839692)
Timeframe: Day 1 and Day 14

Lip Fullness Measurement (Measures the Increase of Lip's Size After the Procedure)

Intervention	µm (Mean)
Young Females (21-30 Years Old)	0.833
Post Menopausal Females	0.360

"The Lip Fullness Grading Scale was used to measure the size of the lips before and after the procedure in both groups. The result presented below is the difference between the means after and before the procedures for each group.~min value: 0 - very thin lips - worse outcome Max value: 4 - full lips- a better outcome" (NCT04839692)
Timeframe: D1 and D14

Wong-Baker FACES Pain Rating Scale

Intervention	units on a scale (Mean)
Young Females (21-30 Years Old)	1.14
Post Menopausal Females	0.78

This scale will be used to record the subject's overall pain from the procedure. There are 6 faces ranging from 0=no pain to 10=the worst pain. (NCT04839692)
Timeframe: Day 1

Article	Year
Protective Role of Melatonin and Its Metabolites in Skin Aging. International journal of molecular sciences, 2022, Jan-22, Volume: 23, Issue:3 Topics: Animals; Antioxidants; Humans; Melatonin; Protective Agents; Skin Aging	2022
Skin Pigmentation Abnormalities and Their Possible Relationship with Skin Aging. International journal of molecular sciences, 2021, Apr-02, Volume: 22, Issue:7 Topics: Autophagy; DNA Damage; Humans; Melanins; Melatonin; Oxidative Stress; Skin Aging; Skin Pigmentation;	2021
Assessing the Potential Role for Topical Melatonin in an Antiaging Skin Regimen. Journal of drugs in dermatology : JDD, 2018, Sep-01, Volume: 17, Issue:9 Topics: Administration, Cutaneous; Antioxidants; Humans; Melatonin; Skin Aging; Sunscreening Agents	2018
Local therapy as basic anti-aging prevention. Acta clinica Croatica, 2010, Volume: 49, Issue:4 Topics: Antioxidants; Emollients; Flavonoids; Humans; Hydroxy Acids; Keratolytic Agents; Melatonin; Phenols;	2010
The antioxidative potential of melatonin in the skin. Current problems in dermatology, 2001, Volume: 29 Topics: Animals; Antioxidants; Ascorbic Acid; Chromans; Dose-Response Relationship, Drug; Dose-Response Rela	2001

Article	Year
Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis. Journal of cosmetic dermatology, 2020, Volume: 19, Issue:4 Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cosmeceuticals; Decanoic Acids; Drug Administration Schedu	2020
Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days. Journal of cosmetic dermatology, 2019, Volume: 18, Issue:3 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Ascorbic Acid; Cosmetics; Face; Female; Healthy	2019
New chitin complexes and their anti-aging activity from inside out. The journal of nutrition, health & aging, 2012, Volume: 16, Issue:3 Topics: Administration, Oral; Administration, Topical; Adult; Antioxidants; Chitin; Dermatologic Agents; Dou	2012

melatonin and Skin Aging