melatonin has been researched along with Sepsis in 102 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether IV melatonin therapy improves redox status and inflammatory responses in surgical patients with severe sepsis, a unicenter, phase II double-blind, randomized, placebo-controlled trial was carried out." | 9.69 | A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit. ( Acuña-Castroviejo, D; Comino-Pardo, A; Domínguez-Bastante, M; Escames, G; Hernández-Magdalena, J; Mansilla-Roselló, A; Olmedo-Martín, C, 2023) |
| "This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19)." | 9.51 | The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients. ( Atrakji, DMQYMAA; Hasan, ZT; Mehuaiden, DAK, 2022) |
| "Sepsis is defined as a dysregulated host response to infection, and high-dose melatonin has been proposed as a treatment due to its antioxidant and anti-inflammatory properties." | 9.51 | Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis. ( Allen, L; Colin, PJ; Galley, HF; Galt, SP; Webster, NR, 2022) |
| "We describe the protocol for a clinical trial design evaluating the effects of simultaneous administration of propolis and melatonin in patients with primary sepsis." | 9.30 | Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies. ( Bagheri Moghaddam, A; Ghayour-Mobarhan, M; Gholizadeh Navashenaq, J; Jarahi, L; Mazloumi Kiapey, SS; Nematy, M; Norouzy, A; Pahlavani, N; Reazvani, R; Safarian, M; Sedaghat, A, 2019) |
| "The objective of this study is to evaluate the therapeutic efficacy of melatonin as an adjuvant therapy in treating neonatal sepsis." | 9.20 | Use of melatonin as an adjuvant therapy in neonatal sepsis. ( Attia, GF; El Frargy, M; El-Sharkawy, HM, 2015) |
| "In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model." | 8.31 | Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway. ( Ateş, Ş; Doğanyiğit, Z; Oflamaz, AO; Söylemez, ESA; Uçar, S; Yilmaz, S, 2023) |
| "This study investigated the synergistic protective effects of melatonin (MEL) and ascorbic acid (vitamin C, ASA) in treating sepsis-induced lung injury in rats." | 8.31 | Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study. ( Çiçek, B; Demir, Ö; Huyut, MT; Tavacı, T; Üstündağ, H; Yüce, N, 2023) |
| "To investigate the combined therapeutic potential of melatonin and ascorbic acid in mitigating sepsis-induced heart and kidney injury in male rats and assess the combination therapy's effects on inflammation, cellular damage, oxidative stress, and vascular function-related markers." | 8.31 | A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats. ( Akbaba, Ö; Demir, Ö; Doğanay, S; Huyut, MT; Kalındemirtaş, FD; Kurt, N; Özgeriş, FB; Üstündağ, H, 2023) |
| "This study aimed to investigate the protective mechanisms of melatonin in an in vitro model of sepsis-induced hepatocyte injury, specifically focusing on mitophagy and mitochondrial biogenesis." | 8.31 | Melatonin Promotes Mitochondrial Biogenesis and Mitochondrial Degradation in Hepatocytes During Sepsis. ( Chen, X; Chen, Z; Hu, B; Liang, L; Zeng, Q; Zheng, M, 2023) |
| "Prior research suggests melatonin has beneficial effects that could improve survival among sepsis patients." | 8.12 | Melatonin use and the risk of 30-day mortality among US veterans with sepsis: A retrospective study. ( Cummings, TH; Hardin, JW; Magagnoli, J; Sutton, SS, 2022) |
| "This study aimed to investigate the possible protective effects of melatonin (MEL) against the damage to testicular tissue in rats caused by polymicrobial sepsis as a result of cecal ligation and perforation (CLP)." | 8.12 | Protective role of melatonin against testicular damage caused by polymicrobial sepsis in adult rats. ( Budak, Ö; Doğanay, S; Erman, G; Şahin, A; Toprak, V, 2022) |
| " Melatonin treatment suppresses ferroptosis and alleviates kidney injury in the context of experimental sepsis by upregulating Nrf2/HO-1 pathway." | 8.12 | Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury. ( An, S; Chen, Z; Gao, Y; Li, J; Lin, B; Lin, X; Qiu, W; Wang, T; Yu, B; Zeng, Z, 2022) |
| "Healthy rats were selected as the samples and divided into blank group, sepsis group and sepsis + melatonin group." | 8.12 | Melatonin relieves sepsis-induced myocardial injury via regulating JAK2/STAT3 signaling pathway. ( Jia, H; Liang, W; Zhen, G; Zheng, X, 2022) |
| "Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy and activating class III deacetylase Sirtuin family members (SIRT1-7)." | 8.02 | Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction. ( An, S; Chen, Z; Fang, H; Han, Y; Huang, Q; Li, L; Wu, J; Xu, S; Zeng, Z, 2021) |
| "Whereas the circadian system controls the daily production of melatonin and the daily activity of the immune system, increasing evidences support the association between circadian misalignment with the alterations in the immune response and melatonin rhythm during sepsis." | 7.96 | Daily Changes in the Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin. ( Acuña-Castroviejo, D; Acuña-Fernández, C; Darias-Delbey, B; Díaz-Casado, ME; Florido-Ruiz, J; Marín, JS; Pérez-Guillama, L; Rusanova, I, 2020) |
| "The aim of the present study is to determine the association of melatonin hormone level on CRP, Total Antioxidant Status, Leukocyte, Procalcitonin, and Malondialdehyde, all acute phase reactants in the dark and light cycle of rats with sepsis model." | 7.96 | Determination of Melatonin Deprivation Impact on Sepsis With Acute Phase Reactants. ( Akbulut, HF; Sekmenli, T; Vatansev, H, 2020) |
| "Melatonin (N‑acetyl‑5‑methoxytryptamine; MT) has been shown to have a protective effect against sepsis‑induced renal injury, however, the mechanisms underlying the function of MT remain to be elucidated." | 7.91 | Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway. ( Dai, W; Deng, Y; Hu, S; Huang, H; Si, L; Xu, L; Zhou, L, 2019) |
| "In this study, we found that melatonin protected against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice." | 7.91 | Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice. ( He, BM; Peng, ZY; Qiao, JF; Wu, Y; Zhang, WX, 2019) |
| "Higher serum melatonin levels have previously been found in patients with severe sepsis who died within 30 days of diagnosis than in survivors." | 7.88 | Serum melatonin levels during the first seven days of severe sepsis diagnosis are associated with sepsis severity and mortality. ( Abreu-González, P; Díaz, C; Ferreres, J; Jiménez, A; Labarta, L; Llanos, C; López, RO; Lorente, L; Martín, MM; Pérez-Cejas, A; Solé-Violán, J, 2018) |
| " Moreover, melatonin blunts the NF-κB/NLRP3 connection during sepsis." | 7.85 | Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. ( Acuña-Castroviejo, D; Djerdjouri, B; Escames, G; Fernández-Gil, B; Fernández-Ortiz, M; Hidalgo-Gutiérrez, A; López, LC; Rahim, I; Reiter, RJ; Sayed, RK, 2017) |
| "Melatonin improves survival and functional impairment including hemolysis, thrombocytopenia, and hypotension when administered in a prophylactic manner or early after initiation of sepsis or endotoxemia." | 7.85 | Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial. ( Brencher, L; Effenberger-Neidnicht, K; Oude Lansink, M, 2017) |
| "The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model." | 7.83 | Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model. ( Arabacı Çakır, E; Çelik, A; Ersoy, ÖF; Kayaoğlu, HA; Lortlar, N; Özkan, N; Özsoy, Z; Özuğurlu, AF; Yenidoğan, E, 2016) |
| "Melatonin has been demonstrated to improve survival after experimental sepsis via antioxidant effects." | 7.80 | Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis. ( Fink, T; Glas, M; Kiefer, D; Kleber, A; Mathes, AM; Rensing, H; Reus, E; Volk, T; Wolf, A; Wolf, B; Wolff, M, 2014) |
| " The purpose of the study was to evaluate the neuroprotective effects of melatonin (MEL) and oxytocin (OT) on the early stage of sepsis by recording compound muscle action potentials and measuring plasma tumor necrosis factor (TNF)-α levels, lipid peroxidation (malondialdehyde; MDA), and total antioxidant capacity." | 7.79 | Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. ( Akdemir, A; Erbaş, O; Ergenoglu, AM; Taskiran, D; Yeniel, AÖ, 2013) |
| " The aim of this study was to evaluate the nocturnal melatonin concentration and total 24-hr excretion of 6-sulfatoxymelatoninsulfate, melatonin's major urinary metabolite, in children with sepsis in the pediatric intensive care unit." | 7.78 | Melatonin status in pediatric intensive care patients with sepsis. ( Bagci, S; Bartmann, P; Horoz, ÖÖ; Müller, A; Reinsberg, J; Yildizdas, D, 2012) |
| " We assessed the association between ambient light and circadian melatonin release, measured by urinary 6-sulfatoxymelatonin (6-SMT), in medical intensive care unit (MICU) patients with severe sepsis." | 7.78 | Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion. ( Netzer, G; Scharf, SM; Shanholtz, C; Silhan, L; Terrin, M; Verceles, AC, 2012) |
| "Human endothelial cells were treated with lipopolysaccharide (LPS) plus peptidoglycan G (PepG) to simulate sepsis, in the presence of melatonin, 6-hydroxymelatonin, tryptamine, or indole-3-carboxylic acid." | 7.77 | Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis. ( Almawash, AM; Galley, HF; Lowes, DA; Reid, VL; Webster, NR, 2011) |
| "The aim of this study was to evaluate whether nocturnal melatonin concentration (NMC) and urinary 6-sulphatoxymelatonin (aMT6s) excretion can predict melatonin status in patients with severe sepsis in the pediatric intensive care unit (PICU)." | 7.77 | Use of nocturnal melatonin concentration and urinary 6-sulfatoxymelatonin excretion to evaluate melatonin status in children with severe sepsis. ( Bagci, S; Bartmann, P; Horoz, OO; Mueller, A; Reinsberg, J; Yildizdas, D, 2011) |
| " The animals were randomized into three experimental groups: (1) controls; (2) endotoxemia; (3) endotoxemia treated with melatonin (10mg/kg)." | 7.74 | The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats. ( Acikgoz, O; Aksu, I; Gonenc, S; Ozdemir, D; Ozkan, H; Tugyan, K; Uysal, N, 2007) |
| "Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 7.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
| "Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 7.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
| " In contrast, circadian rhythm was preserved in nonseptic ICU patients, indicating that impaired circadian melatonin secretion in septic patients is mainly related to the presence of severe sepsis and/or concomitant medication." | 7.71 | Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. ( Delle-Karth, G; Ferti, L; Koreny, M; Marktl, W; Mundigler, G; Siostrzonek, P; Steindl-Munda, P; Zehetgruber, M, 2002) |
| "Melatonin is a hormone that regulates sleep and wakefulness, and it is associated with a reduced risk of death in patients with sepsis." | 6.82 | Melatonin: A window into the organ-protective effects of sepsis. ( Huang, X; Lan, Y; Lei, Y; Li, J; Liu, R; Luo, X; Yang, F; Zeng, F, 2022) |
| "Melatonin was rapidly cleared at all doses with a median [range] elimination half-life of 51." | 6.79 | Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis. ( Allen, L; Aucott, LS; Cameron, G; Galley, HF; Lowes, DA; Webster, NR, 2014) |
| "Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other organs and many studies confirm its benefits against oxidative stress including lipid peroxidation, protein mutilation and molecular degeneration in various organs, including the liver." | 6.53 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review. ( Alatorre-Jiménez, MA; Almeida-Souza, P; Cantín-Golet, A; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Reiter, RJ; Reyes-Gonzales, MC; Ruiz-Ruiz, FJ; Tan, DX, 2016) |
| "Melatonin is a versatile molecule, synthesized not only by the pineal gland, but also in small amounts by many other organs like retina, gastrointestinal tract, thymus, bone marrow, lymphocytes etc." | 6.48 | Melatonin in bacterial and viral infections with focus on sepsis: a review. ( Kato, H; Mohamed, M; Srinivasan, V, 2012) |
| "Melatonin has multiple antioxidant action and anti-inflammatory effects, including regulating mitophagy and inflammatory cytokine expression." | 5.91 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy. ( Li, S; Ling, J; Xiong, F; Xu, T; Yu, S, 2023) |
| "Melatonin pretreatment significantly inhibited pathological injury, inflammatory response, oxidative stress, and apoptosis in LPS-treated lung tissues and LPS-treated lung epithelial cells." | 5.72 | A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2. ( Chenzhen, X; Donghang, L; Guorui, L; Ning, L; Qing, G; Rui, X; Tinglv, F; Xiaojing, W, 2022) |
| "To determine whether IV melatonin therapy improves redox status and inflammatory responses in surgical patients with severe sepsis, a unicenter, phase II double-blind, randomized, placebo-controlled trial was carried out." | 5.69 | A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit. ( Acuña-Castroviejo, D; Comino-Pardo, A; Domínguez-Bastante, M; Escames, G; Hernández-Magdalena, J; Mansilla-Roselló, A; Olmedo-Martín, C, 2023) |
| "Melatonin treatment may have a therapeutic effect against sepsis since it prevents the increase in serum VEGF level." | 5.62 | Investigation of the effect of melatonin administration on inflammatory mediators; MMP-2, TGF-β and VEGF levels in rats with sepsis. ( Betül Tuncer, F; Boz, M; Çakıroğlu, H; Çokluk, E; Doğanay, S; Ramazan Şekeroğlu, M, 2021) |
| "Improvements in encephalopathy and medical stabilization did not rapidly normalize rhythms." | 5.56 | Factors Disrupting Melatonin Secretion Rhythms During Critical Illness. ( Abbott, SM; Eed, J; Gendy, M; Liotta, EM; Lizza, BD; Maas, MB; Naidech, AM; Reid, KJ; Zee, PC, 2020) |
| "This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19)." | 5.51 | The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients. ( Atrakji, DMQYMAA; Hasan, ZT; Mehuaiden, DAK, 2022) |
| "Sepsis is defined as a dysregulated host response to infection, and high-dose melatonin has been proposed as a treatment due to its antioxidant and anti-inflammatory properties." | 5.51 | Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis. ( Allen, L; Colin, PJ; Galley, HF; Galt, SP; Webster, NR, 2022) |
| "Melatonin (20 mg/kg) was intraperitoneally (i." | 5.51 | Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway. ( Chen, J; Tao, X; Wang, D; Xia, H; Zhang, H; Zhang, L, 2019) |
| "Melatonin treatment inhibited peripheral tissue inflammation and tissue damage in a cecal ligation puncture (CLP)-induced polymicrobial sepsis model, consequently reducing the mortality of the mice." | 5.51 | Protective Effect of Melatonin Against Polymicrobial Sepsis Is Mediated by the Anti-bacterial Effect of Neutrophils. ( Jin, JO; Kwak, M; Lee, PCW; Xu, L; Zhang, L; Zhang, W, 2019) |
| "Melatonin was administrated to rats intraperitoneally (30 mg/kg)." | 5.43 | Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism. ( An, R; Li, H; Liu, H; Shen, G; Sun, L; Xi, C; Zhang, S; Zhao, L, 2016) |
| "Melatonin was administrated intraperitoneally (30 mg/kg)." | 5.42 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. ( An, R; Li, X; Lin, Y; Liu, H; Qu, Y; Reiter, RJ; Yang, X; Yang, Y; Yue, L; Zhao, L, 2015) |
| "Sepsis was induced by cecal ligation and puncture, and heart mitochondria were analyzed for NOS expression and activity, nitrites, lipid peroxidation, glutathione and glutathione redox enzymes, oxidized proteins, and respiratory chain activity in vehicle- and melatonin-treated mice." | 5.40 | The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS. ( Acuña-Castroviejo, D; Doerrier, C; Escames, G; García, JA; López, A; López, LC; Luna-Sánchez, M; Ortiz, F; Venegas, C; Volt, H, 2014) |
| "Melatonin treatment of the CLP group restored these responses." | 5.32 | Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder. ( Ayanoğlu-Dülger, G; Kapucu, C; Paskaloğlu, K; Sener, G, 2004) |
| "Melatonin has a protective effect on hepatocyte oxidative metabolism, improving mitochondrial function by counteracting oxidative stress." | 5.32 | Melatonin protects from, but does not reverse, the effects of mediators of sepsis on liver bioenergetics. ( Basile, M; Eaton, S; Gitto, E; Pierro, A; Romeo, C; Spitz, L, 2004) |
| "Sepsis has been associated with a lipopolysaccharide (LPS) induced bacterial infection and causes biochemical, hemodynamic and physiological alterations in a system." | 5.32 | Lipid peroxidation and deformability of red blood cells in experimental sepsis in rats: The protective effects of melatonin. ( Aydogan, S; Baskurt, O; Yalcin, O; Yapislar, H; Yerer, MB, 2004) |
| "We describe the protocol for a clinical trial design evaluating the effects of simultaneous administration of propolis and melatonin in patients with primary sepsis." | 5.30 | Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies. ( Bagheri Moghaddam, A; Ghayour-Mobarhan, M; Gholizadeh Navashenaq, J; Jarahi, L; Mazloumi Kiapey, SS; Nematy, M; Norouzy, A; Pahlavani, N; Reazvani, R; Safarian, M; Sedaghat, A, 2019) |
| "Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study." | 5.29 | Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996) |
| "The objective of this study is to evaluate the therapeutic efficacy of melatonin as an adjuvant therapy in treating neonatal sepsis." | 5.20 | Use of melatonin as an adjuvant therapy in neonatal sepsis. ( Attia, GF; El Frargy, M; El-Sharkawy, HM, 2015) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| " Included in this group of conditions is asphyxia, respiratory distress syndrome and sepsis and the review also summarizes the literature related to clinical trials of antioxidant therapies and of melatonin, a highly effective antioxidant and free radical scavenger." | 4.85 | Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. ( Barberi, I; Gitto, E; Gitto, P; Pellegrino, S; Reiter, RJ, 2009) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model." | 4.31 | Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway. ( Ateş, Ş; Doğanyiğit, Z; Oflamaz, AO; Söylemez, ESA; Uçar, S; Yilmaz, S, 2023) |
| "Urinary melatonin concentration below the certain cut-off values in the early neonatal period may serve as one of the predictors of adverse outcomes such as BPD, ROP, and late-onset sepsis in the late neonatal period in preterm infants." | 4.31 | The relationship of melatonin concentration in preterm infants and adverse outcomes in the late neonatal period. ( Kozak, K; Pavlyshyn, Н; Sarapuk, I, 2023) |
| "Our results showed that melatonin pretreatment showed an obvious protective effect on sepsis and septic myocardial injury, which was related to the attenuation of inflammation and oxidative stress, the improvement of mitochondrial function, the regulation of endoplasmic reticulum stress (ERS), and the activation of the AMPK signaling pathway." | 4.31 | Protection of melatonin treatment and combination with traditional antibiotics against septic myocardial injury. ( Di, W; Jin, Z; Lei, W; Liu, Q; Lu, C; Xu, X; Yang, W; Yang, Y; Zhang, S; Zhao, H, 2023) |
| "This study investigated the synergistic protective effects of melatonin (MEL) and ascorbic acid (vitamin C, ASA) in treating sepsis-induced lung injury in rats." | 4.31 | Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study. ( Çiçek, B; Demir, Ö; Huyut, MT; Tavacı, T; Üstündağ, H; Yüce, N, 2023) |
| " Melatonin, however, upregulated USP8 expression, thus maintaining the stability of NICD and Notch signaling, which ultimately reduced EC injury in our sepsis model and elevated the survival rate of septic mice." | 4.31 | Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis. ( Liu, T; Lu, G; Wang, Y; Yan, G; Ying, J; Zhang, C; Zhou, Y, 2023) |
| "To investigate the combined therapeutic potential of melatonin and ascorbic acid in mitigating sepsis-induced heart and kidney injury in male rats and assess the combination therapy's effects on inflammation, cellular damage, oxidative stress, and vascular function-related markers." | 4.31 | A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats. ( Akbaba, Ö; Demir, Ö; Doğanay, S; Huyut, MT; Kalındemirtaş, FD; Kurt, N; Özgeriş, FB; Üstündağ, H, 2023) |
| "This study aimed to investigate the protective mechanisms of melatonin in an in vitro model of sepsis-induced hepatocyte injury, specifically focusing on mitophagy and mitochondrial biogenesis." | 4.31 | Melatonin Promotes Mitochondrial Biogenesis and Mitochondrial Degradation in Hepatocytes During Sepsis. ( Chen, X; Chen, Z; Hu, B; Liang, L; Zeng, Q; Zheng, M, 2023) |
| "Prior research suggests melatonin has beneficial effects that could improve survival among sepsis patients." | 4.12 | Melatonin use and the risk of 30-day mortality among US veterans with sepsis: A retrospective study. ( Cummings, TH; Hardin, JW; Magagnoli, J; Sutton, SS, 2022) |
| "This study aimed to investigate the possible protective effects of melatonin (MEL) against the damage to testicular tissue in rats caused by polymicrobial sepsis as a result of cecal ligation and perforation (CLP)." | 4.12 | Protective role of melatonin against testicular damage caused by polymicrobial sepsis in adult rats. ( Budak, Ö; Doğanay, S; Erman, G; Şahin, A; Toprak, V, 2022) |
| " Melatonin treatment suppresses ferroptosis and alleviates kidney injury in the context of experimental sepsis by upregulating Nrf2/HO-1 pathway." | 4.12 | Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury. ( An, S; Chen, Z; Gao, Y; Li, J; Lin, B; Lin, X; Qiu, W; Wang, T; Yu, B; Zeng, Z, 2022) |
| "Healthy rats were selected as the samples and divided into blank group, sepsis group and sepsis + melatonin group." | 4.12 | Melatonin relieves sepsis-induced myocardial injury via regulating JAK2/STAT3 signaling pathway. ( Jia, H; Liang, W; Zhen, G; Zheng, X, 2022) |
| "Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy and activating class III deacetylase Sirtuin family members (SIRT1-7)." | 4.02 | Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction. ( An, S; Chen, Z; Fang, H; Han, Y; Huang, Q; Li, L; Wu, J; Xu, S; Zeng, Z, 2021) |
| "Whereas the circadian system controls the daily production of melatonin and the daily activity of the immune system, increasing evidences support the association between circadian misalignment with the alterations in the immune response and melatonin rhythm during sepsis." | 3.96 | Daily Changes in the Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin. ( Acuña-Castroviejo, D; Acuña-Fernández, C; Darias-Delbey, B; Díaz-Casado, ME; Florido-Ruiz, J; Marín, JS; Pérez-Guillama, L; Rusanova, I, 2020) |
| "The aim of the present study is to determine the association of melatonin hormone level on CRP, Total Antioxidant Status, Leukocyte, Procalcitonin, and Malondialdehyde, all acute phase reactants in the dark and light cycle of rats with sepsis model." | 3.96 | Determination of Melatonin Deprivation Impact on Sepsis With Acute Phase Reactants. ( Akbulut, HF; Sekmenli, T; Vatansev, H, 2020) |
| "Total daily and diurnal variation of 6-sulfatoxymelatonin excretion is heterogeneously maintained early in pediatric critical illness." | 3.96 | Total Daily Production and Periodicity of Melatonin Metabolite in Critically Ill Children. ( Foster, JR; Fraser, DD; Miller, MR; Seabrook, JA; Tijssen, JA, 2020) |
| "Melatonin (N‑acetyl‑5‑methoxytryptamine; MT) has been shown to have a protective effect against sepsis‑induced renal injury, however, the mechanisms underlying the function of MT remain to be elucidated." | 3.91 | Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway. ( Dai, W; Deng, Y; Hu, S; Huang, H; Si, L; Xu, L; Zhou, L, 2019) |
| "In this study, we found that melatonin protected against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice." | 3.91 | Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice. ( He, BM; Peng, ZY; Qiao, JF; Wu, Y; Zhang, WX, 2019) |
| "Higher serum melatonin levels have previously been found in patients with severe sepsis who died within 30 days of diagnosis than in survivors." | 3.88 | Serum melatonin levels during the first seven days of severe sepsis diagnosis are associated with sepsis severity and mortality. ( Abreu-González, P; Díaz, C; Ferreres, J; Jiménez, A; Labarta, L; Llanos, C; López, RO; Lorente, L; Martín, MM; Pérez-Cejas, A; Solé-Violán, J, 2018) |
| "Melatonin could represent a useful clinical adjunct in the treatment of sepsis as an immunomodulator." | 3.88 | Altered endotoxin responsiveness in healthy children with Down syndrome. ( Balfe, J; Doherty, DG; Franklin, O; Huggard, D; Lagan, N; Leahy, TR; McGrane, F; Melo, AM; Molloy, EJ; Moreno, A; Roche, E, 2018) |
| " Moreover, melatonin blunts the NF-κB/NLRP3 connection during sepsis." | 3.85 | Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. ( Acuña-Castroviejo, D; Djerdjouri, B; Escames, G; Fernández-Gil, B; Fernández-Ortiz, M; Hidalgo-Gutiérrez, A; López, LC; Rahim, I; Reiter, RJ; Sayed, RK, 2017) |
| "Melatonin improves survival and functional impairment including hemolysis, thrombocytopenia, and hypotension when administered in a prophylactic manner or early after initiation of sepsis or endotoxemia." | 3.85 | Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial. ( Brencher, L; Effenberger-Neidnicht, K; Oude Lansink, M, 2017) |
| "The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model." | 3.83 | Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model. ( Arabacı Çakır, E; Çelik, A; Ersoy, ÖF; Kayaoğlu, HA; Lortlar, N; Özkan, N; Özsoy, Z; Özuğurlu, AF; Yenidoğan, E, 2016) |
| " Serum levels of melatonin were measured at moment of severe sepsis diagnosis." | 3.81 | Serum melatonin levels are associated with mortality in severe septic patients. ( Abreu-González, P; Borreguero-León, JM; de la Cruz, T; Díaz, C; Ferreres, J; Jiménez, A; Labarta, L; Lorente, L; Martín, MM; Solé-Violán, J, 2015) |
| "We determined the NF-κB- and NOD-like receptor (NLR)P3-dependent molecular mechanisms involved in sepsis and evaluated the role of retinoid-related orphan receptor (ROR)-α in melatonin's anti-inflammatory actions." | 3.81 | Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice. ( Acuña-Castroviejo, D; Doerrier, C; Escames, G; García, JA; López, LC; Venegas, C; Volt, H, 2015) |
| "Melatonin has been demonstrated to improve survival after experimental sepsis via antioxidant effects." | 3.80 | Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis. ( Fink, T; Glas, M; Kiefer, D; Kleber, A; Mathes, AM; Rensing, H; Reus, E; Volk, T; Wolf, A; Wolf, B; Wolff, M, 2014) |
| "Production of reactive oxygen species was strongly increased in the aorta and liver after 5h of polymicrobial sepsis which was entirely inhibited by treatment with melatonin." | 3.80 | Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response. ( Fink, T; Kleber, A; Kubulus, D; Rössler, D; Speer, T; Volk, T; Wolf, B, 2014) |
| " The purpose of the study was to evaluate the neuroprotective effects of melatonin (MEL) and oxytocin (OT) on the early stage of sepsis by recording compound muscle action potentials and measuring plasma tumor necrosis factor (TNF)-α levels, lipid peroxidation (malondialdehyde; MDA), and total antioxidant capacity." | 3.79 | Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. ( Akdemir, A; Erbaş, O; Ergenoglu, AM; Taskiran, D; Yeniel, AÖ, 2013) |
| " As melatonin is an antioxidant with the potential to scavenge radicals in mitochondria, we therefore employed a sepsis model, that is, cecal ligation and double puncture (CLP) in rats, to study the melatonin effects on: (i), myocardial mitochondrial function; (ii), heart systolic function; and (iii), prognosis of septic rats." | 3.79 | Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury. ( Chai, W; Chen, X; Liu, D; Long, Y; Rui, X; Wang, H; Wang, X; Yang, Q; Zhang, H; Zhang, Q; Zhou, X, 2013) |
| " The aim of this study was to evaluate the nocturnal melatonin concentration and total 24-hr excretion of 6-sulfatoxymelatoninsulfate, melatonin's major urinary metabolite, in children with sepsis in the pediatric intensive care unit." | 3.78 | Melatonin status in pediatric intensive care patients with sepsis. ( Bagci, S; Bartmann, P; Horoz, ÖÖ; Müller, A; Reinsberg, J; Yildizdas, D, 2012) |
| " We assessed the association between ambient light and circadian melatonin release, measured by urinary 6-sulfatoxymelatonin (6-SMT), in medical intensive care unit (MICU) patients with severe sepsis." | 3.78 | Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion. ( Netzer, G; Scharf, SM; Shanholtz, C; Silhan, L; Terrin, M; Verceles, AC, 2012) |
| "Human endothelial cells were treated with lipopolysaccharide (LPS) plus peptidoglycan G (PepG) to simulate sepsis, in the presence of melatonin, 6-hydroxymelatonin, tryptamine, or indole-3-carboxylic acid." | 3.77 | Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis. ( Almawash, AM; Galley, HF; Lowes, DA; Reid, VL; Webster, NR, 2011) |
| "The aim of this study was to evaluate whether nocturnal melatonin concentration (NMC) and urinary 6-sulphatoxymelatonin (aMT6s) excretion can predict melatonin status in patients with severe sepsis in the pediatric intensive care unit (PICU)." | 3.77 | Use of nocturnal melatonin concentration and urinary 6-sulfatoxymelatonin excretion to evaluate melatonin status in children with severe sepsis. ( Bagci, S; Bartmann, P; Horoz, OO; Mueller, A; Reinsberg, J; Yildizdas, D, 2011) |
| " The animals were randomized into three experimental groups: (1) controls; (2) endotoxemia; (3) endotoxemia treated with melatonin (10mg/kg)." | 3.74 | The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats. ( Acikgoz, O; Aksu, I; Gonenc, S; Ozdemir, D; Ozkan, H; Tugyan, K; Uysal, N, 2007) |
| "Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 3.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
| "Sepsis provokes an induction of inducible nitric oxide synthase (iNOS) and melatonin down-regulates its expression and activity." | 3.73 | Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin. ( Acuña-Castroviejo, D; Escames, G; León, J; López, LC; Tapias, V; Utrilla, P, 2006) |
| "Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 3.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
| " In contrast, circadian rhythm was preserved in nonseptic ICU patients, indicating that impaired circadian melatonin secretion in septic patients is mainly related to the presence of severe sepsis and/or concomitant medication." | 3.71 | Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. ( Delle-Karth, G; Ferti, L; Koreny, M; Marktl, W; Mundigler, G; Siostrzonek, P; Steindl-Munda, P; Zehetgruber, M, 2002) |
| "The study seems to show a possible correlation between impaired rhythm of melatonin secretion and postoperative insomnia and postoperative sepsis in old patients undergoing surgery." | 3.70 | [The role of melatonin in the immediate postoperative period in elderly patients]. ( Barnabei, R; Cianca, G; Citone, G; Leardi, S; Necozione, S; Simi, M; Tavone, E, 2000) |
| "Melatonin is a hormone that regulates sleep and wakefulness, and it is associated with a reduced risk of death in patients with sepsis." | 2.82 | Melatonin: A window into the organ-protective effects of sepsis. ( Huang, X; Lan, Y; Lei, Y; Li, J; Liu, R; Luo, X; Yang, F; Zeng, F, 2022) |
| "Melatonin was rapidly cleared at all doses with a median [range] elimination half-life of 51." | 2.79 | Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis. ( Allen, L; Aucott, LS; Cameron, G; Galley, HF; Lowes, DA; Webster, NR, 2014) |
| "Sepsis is one of the main causes of death among critically ill patients." | 2.55 | Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. ( Prauchner, CA, 2017) |
| "Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other organs and many studies confirm its benefits against oxidative stress including lipid peroxidation, protein mutilation and molecular degeneration in various organs, including the liver." | 2.53 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review. ( Alatorre-Jiménez, MA; Almeida-Souza, P; Cantín-Golet, A; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Reiter, RJ; Reyes-Gonzales, MC; Ruiz-Ruiz, FJ; Tan, DX, 2016) |
| "Melatonin is a versatile molecule, synthesized not only by the pineal gland, but also in small amounts by many other organs like retina, gastrointestinal tract, thymus, bone marrow, lymphocytes etc." | 2.48 | Melatonin in bacterial and viral infections with focus on sepsis: a review. ( Kato, H; Mohamed, M; Srinivasan, V, 2012) |
| "Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect." | 2.48 | Melatonin utility in neonates and children. ( Chen, YC; Huang, LT; Sheen, JM; Tain, YL, 2012) |
| "Melatonin plays an important physiologic role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control, and regulation of mood." | 2.46 | Melatonin in septic shock: some recent concepts. ( Cardinali, DP; Kato, H; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2010) |
| "Melatonin has multiple antioxidant action and anti-inflammatory effects, including regulating mitophagy and inflammatory cytokine expression." | 1.91 | Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy. ( Li, S; Ling, J; Xiong, F; Xu, T; Yu, S, 2023) |
| "Sepsis is a life-threatening organ dysfunction." | 1.72 | Melatonin arrests excessive inflammatory response and apoptosis in lipopolysaccharide-damaged rat liver: A deeper insight into its mechanism of action. ( Lazarević, M; Milić, D; Mitić, K; Sokolović, D; Sokolović, DT; Stanojković, Z, 2022) |
| "Melatonin pretreatment significantly inhibited pathological injury, inflammatory response, oxidative stress, and apoptosis in LPS-treated lung tissues and LPS-treated lung epithelial cells." | 1.72 | A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2. ( Chenzhen, X; Donghang, L; Guorui, L; Ning, L; Qing, G; Rui, X; Tinglv, F; Xiaojing, W, 2022) |
| "Melatonin treatment may have a therapeutic effect against sepsis since it prevents the increase in serum VEGF level." | 1.62 | Investigation of the effect of melatonin administration on inflammatory mediators; MMP-2, TGF-β and VEGF levels in rats with sepsis. ( Betül Tuncer, F; Boz, M; Çakıroğlu, H; Çokluk, E; Doğanay, S; Ramazan Şekeroğlu, M, 2021) |
| "Melatonin and irisin cotreatment effectively inhibited the Mst1-JNK pathway and, thus, promoted cardiomyocyte survival and mitochondrial homeostasis." | 1.56 | Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways. ( Deng, Y; Hu, Y; Li, Q; Lu, J; Ouyang, H; Xia, F; Zheng, S; Zhong, J, 2020) |
| "Improvements in encephalopathy and medical stabilization did not rapidly normalize rhythms." | 1.56 | Factors Disrupting Melatonin Secretion Rhythms During Critical Illness. ( Abbott, SM; Eed, J; Gendy, M; Liotta, EM; Lizza, BD; Maas, MB; Naidech, AM; Reid, KJ; Zee, PC, 2020) |
| "Melatonin (20 mg/kg) was intraperitoneally (i." | 1.51 | Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway. ( Chen, J; Tao, X; Wang, D; Xia, H; Zhang, H; Zhang, L, 2019) |
| "Melatonin treatment inhibited peripheral tissue inflammation and tissue damage in a cecal ligation puncture (CLP)-induced polymicrobial sepsis model, consequently reducing the mortality of the mice." | 1.51 | Protective Effect of Melatonin Against Polymicrobial Sepsis Is Mediated by the Anti-bacterial Effect of Neutrophils. ( Jin, JO; Kwak, M; Lee, PCW; Xu, L; Zhang, L; Zhang, W, 2019) |
| "The melatonin treatment attenuated septic myocardial injury in a comparable manner to the genetic depletion of Ripk3." | 1.51 | Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function. ( Chen, S; Chen, Y; Guo, Z; Hu, Y; Liu, J; Lu, J; Tan, Y; Xiao, X; Zheng, S; Zhong, J; Zhu, P, 2019) |
| " Accordingly, this work indicates that mPEG-b-PPS-NPs show potential as an ROS-mediated on-demand drug delivery system for improving Mel bioavailability and treating oxidative stress-associated diseases such as sepsis-induced acute liver injury." | 1.46 | Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice. ( Chen, G; Deng, H; Dong, A; Lu, M; Song, X; Xia, S; You, G; Zhang, Y; Zhao, J; Zhao, L; Zhou, H, 2017) |
| "Melatonin was administrated to rats intraperitoneally (30 mg/kg)." | 1.43 | Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism. ( An, R; Li, H; Liu, H; Shen, G; Sun, L; Xi, C; Zhang, S; Zhao, L, 2016) |
| "Melatonin was administrated intraperitoneally (30 mg/kg)." | 1.42 | Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling. ( An, R; Li, X; Lin, Y; Liu, H; Qu, Y; Reiter, RJ; Yang, X; Yang, Y; Yue, L; Zhao, L, 2015) |
| "Sepsis was induced by cecal ligation and puncture, and heart mitochondria were analyzed for NOS expression and activity, nitrites, lipid peroxidation, glutathione and glutathione redox enzymes, oxidized proteins, and respiratory chain activity in vehicle- and melatonin-treated mice." | 1.40 | The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS. ( Acuña-Castroviejo, D; Doerrier, C; Escames, G; García, JA; López, A; López, LC; Luna-Sánchez, M; Ortiz, F; Venegas, C; Volt, H, 2014) |
| "Melatonin treatment blunted sepsis-induced inducible nitric oxide synthase/inducible mitochondrial nitric oxide synthase isoforms, prevented the impairment of mitochondrial homeostasis under sepsis, and restored ATP production." | 1.34 | Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice. ( Acuña-Castroviejo, D; Escames, G; García, JA; López, A; López, LC; Ortiz, F; Ros, E, 2007) |
| "Melatonin has not been used in adult patients with acute oxidative stress." | 1.34 | [Melatonin against surgical stress]. ( Gögenur, I; Kücükakin, B; Rosenberg, J, 2007) |
| "Melatonin treatment counteracted both the changes in mtNOS activity and rises in oxidative stress; the indole also restored mitochondrial respiratory chain in septic iNOS(+/+) mice." | 1.33 | Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice. ( Acuña-Castroviejo, D; Escames, G; Hitos, AB; León, J; López, LC; Reiter, RJ; Rodríguez, MI; Tapias, V; Utrilla, P, 2006) |
| "Melatonin treatment normalized the production of ATP in iNOS+/+ mice, without affecting iNOS-/- animals." | 1.33 | Melatonin restores the mitochondrial production of ATP in septic mice. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006) |
| "Melatonin treatment of the CLP group restored these responses." | 1.32 | Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder. ( Ayanoğlu-Dülger, G; Kapucu, C; Paskaloğlu, K; Sener, G, 2004) |
| "Melatonin has a protective effect on hepatocyte oxidative metabolism, improving mitochondrial function by counteracting oxidative stress." | 1.32 | Melatonin protects from, but does not reverse, the effects of mediators of sepsis on liver bioenergetics. ( Basile, M; Eaton, S; Gitto, E; Pierro, A; Romeo, C; Spitz, L, 2004) |
| "Sepsis has been associated with a lipopolysaccharide (LPS) induced bacterial infection and causes biochemical, hemodynamic and physiological alterations in a system." | 1.32 | Lipid peroxidation and deformability of red blood cells in experimental sepsis in rats: The protective effects of melatonin. ( Aydogan, S; Baskurt, O; Yalcin, O; Yapislar, H; Yerer, MB, 2004) |
| "Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study." | 1.29 | Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.98) | 18.2507 |
| 2000's | 21 (20.59) | 29.6817 |
| 2010's | 47 (46.08) | 24.3611 |
| 2020's | 33 (32.35) | 2.80 |
| Authors | Studies |
|---|---|
| Çokluk, E | 1 |
| Doğanay, S | 3 |
| Ramazan Şekeroğlu, M | 1 |
| Betül Tuncer, F | 1 |
| Çakıroğlu, H | 1 |
| Boz, M | 1 |
| Hasan, ZT | 1 |
| Atrakji, DMQYMAA | 1 |
| Mehuaiden, DAK | 1 |
| Kanova, M | 1 |
| Kohout, P | 1 |
| Sutton, SS | 1 |
| Magagnoli, J | 1 |
| Cummings, TH | 1 |
| Hardin, JW | 1 |
| Budak, Ö | 1 |
| Toprak, V | 1 |
| Erman, G | 1 |
| Şahin, A | 1 |
| Liu, R | 1 |
| Luo, X | 1 |
| Li, J | 2 |
| Lei, Y | 1 |
| Zeng, F | 1 |
| Huang, X | 1 |
| Lan, Y | 1 |
| Yang, F | 1 |
| Galley, HF | 4 |
| Allen, L | 2 |
| Colin, PJ | 1 |
| Galt, SP | 1 |
| Webster, NR | 4 |
| Sokolović, D | 1 |
| Lazarević, M | 1 |
| Milić, D | 1 |
| Stanojković, Z | 1 |
| Mitić, K | 1 |
| Sokolović, DT | 1 |
| Qiu, W | 1 |
| An, S | 2 |
| Wang, T | 1 |
| Yu, B | 1 |
| Zeng, Z | 2 |
| Chen, Z | 3 |
| Lin, B | 1 |
| Lin, X | 1 |
| Gao, Y | 1 |
| Mansilla-Roselló, A | 3 |
| Hernández-Magdalena, J | 3 |
| Domínguez-Bastante, M | 3 |
| Olmedo-Martín, C | 3 |
| Comino-Pardo, A | 3 |
| Escames, G | 14 |
| Acuña-Castroviejo, D | 15 |
| Ning, L | 3 |
| Rui, X | 4 |
| Guorui, L | 3 |
| Tinglv, F | 3 |
| Donghang, L | 3 |
| Chenzhen, X | 3 |
| Xiaojing, W | 3 |
| Qing, G | 3 |
| Yilmaz, S | 1 |
| Doğanyiğit, Z | 1 |
| Oflamaz, AO | 1 |
| Ateş, Ş | 1 |
| Uçar, S | 1 |
| Söylemez, ESA | 1 |
| Pavlyshyn, Н | 1 |
| Sarapuk, I | 1 |
| Kozak, K | 1 |
| Liu, Y | 1 |
| Wang, D | 3 |
| Li, T | 2 |
| Xu, L | 3 |
| Li, Z | 1 |
| Bai, X | 1 |
| Tang, M | 1 |
| Wang, Y | 2 |
| Di, W | 1 |
| Jin, Z | 1 |
| Lei, W | 1 |
| Liu, Q | 1 |
| Yang, W | 1 |
| Zhang, S | 2 |
| Lu, C | 1 |
| Xu, X | 1 |
| Yang, Y | 3 |
| Zhao, H | 1 |
| Üstündağ, H | 2 |
| Demir, Ö | 2 |
| Çiçek, B | 1 |
| Huyut, MT | 2 |
| Yüce, N | 1 |
| Tavacı, T | 1 |
| Liu, T | 1 |
| Zhang, C | 2 |
| Ying, J | 1 |
| Yan, G | 1 |
| Zhou, Y | 1 |
| Lu, G | 1 |
| Kalındemirtaş, FD | 1 |
| Kurt, N | 1 |
| Özgeriş, FB | 1 |
| Akbaba, Ö | 1 |
| Hu, B | 1 |
| Liang, L | 1 |
| Zheng, M | 1 |
| Chen, X | 2 |
| Zeng, Q | 1 |
| Taha, AM | 1 |
| Mahmoud, AM | 1 |
| Ghonaim, MM | 1 |
| Kamran, A | 1 |
| AlSamhori, JF | 1 |
| AlBarakat, MM | 1 |
| Shrestha, AB | 1 |
| Jaiswal, V | 1 |
| Reiter, RJ | 9 |
| Ling, J | 1 |
| Yu, S | 1 |
| Xiong, F | 1 |
| Xu, T | 1 |
| Li, S | 1 |
| Acuña-Fernández, C | 2 |
| Marín, JS | 1 |
| Díaz-Casado, ME | 4 |
| Rusanova, I | 3 |
| Darias-Delbey, B | 1 |
| Pérez-Guillama, L | 1 |
| Florido-Ruiz, J | 1 |
| Dai, W | 1 |
| Huang, H | 1 |
| Si, L | 1 |
| Hu, S | 2 |
| Zhou, L | 1 |
| Deng, Y | 2 |
| Pahlavani, N | 1 |
| Sedaghat, A | 1 |
| Bagheri Moghaddam, A | 1 |
| Mazloumi Kiapey, SS | 1 |
| Gholizadeh Navashenaq, J | 1 |
| Jarahi, L | 1 |
| Reazvani, R | 1 |
| Norouzy, A | 1 |
| Nematy, M | 1 |
| Safarian, M | 1 |
| Ghayour-Mobarhan, M | 1 |
| Supinski, GS | 1 |
| Schroder, EA | 1 |
| Callahan, LA | 1 |
| Ben-Hamouda, N | 1 |
| Challet, E | 1 |
| Akbulut, HF | 1 |
| Vatansev, H | 1 |
| Sekmenli, T | 1 |
| Ouyang, H | 1 |
| Li, Q | 1 |
| Zhong, J | 2 |
| Xia, F | 1 |
| Zheng, S | 2 |
| Lu, J | 2 |
| Hu, Y | 2 |
| Maas, MB | 1 |
| Lizza, BD | 1 |
| Abbott, SM | 1 |
| Liotta, EM | 1 |
| Gendy, M | 1 |
| Eed, J | 1 |
| Naidech, AM | 1 |
| Reid, KJ | 1 |
| Zee, PC | 1 |
| Zhen, G | 1 |
| Liang, W | 1 |
| Jia, H | 1 |
| Zheng, X | 1 |
| Foster, JR | 1 |
| Tijssen, JA | 1 |
| Miller, MR | 1 |
| Seabrook, JA | 1 |
| Fraser, DD | 1 |
| Pi, QZ | 1 |
| Wang, XW | 1 |
| Jian, ZL | 1 |
| Chen, D | 1 |
| Wu, QC | 1 |
| Pi, Q | 1 |
| Luo, M | 1 |
| Cheng, Z | 1 |
| Liang, X | 1 |
| Luo, S | 1 |
| Xia, Y | 2 |
| Xu, S | 1 |
| Li, L | 1 |
| Wu, J | 1 |
| Fang, H | 1 |
| Han, Y | 1 |
| Huang, Q | 1 |
| He, F | 1 |
| Wu, X | 1 |
| Zhang, Q | 2 |
| Li, Y | 1 |
| Ye, Y | 1 |
| Li, P | 1 |
| Chen, S | 2 |
| Peng, Y | 1 |
| Hardeland, R | 1 |
| Rahim, I | 2 |
| Djerdjouri, B | 1 |
| Sayed, RK | 1 |
| Fernández-Ortiz, M | 3 |
| Fernández-Gil, B | 2 |
| Hidalgo-Gutiérrez, A | 1 |
| López, LC | 10 |
| Brencher, L | 1 |
| Oude Lansink, M | 1 |
| Effenberger-Neidnicht, K | 1 |
| Solera-Marín, J | 1 |
| Sayed, RKA | 1 |
| Chen, G | 1 |
| Deng, H | 1 |
| Song, X | 1 |
| Lu, M | 1 |
| Zhao, L | 3 |
| Xia, S | 1 |
| You, G | 1 |
| Zhao, J | 1 |
| Zhang, Y | 1 |
| Dong, A | 1 |
| Zhou, H | 1 |
| Lorente, L | 2 |
| Martín, MM | 2 |
| Abreu-González, P | 2 |
| Pérez-Cejas, A | 1 |
| López, RO | 1 |
| Ferreres, J | 2 |
| Solé-Violán, J | 2 |
| Labarta, L | 2 |
| Díaz, C | 2 |
| Llanos, C | 1 |
| Jiménez, A | 2 |
| Varga, N | 1 |
| Ruiz-Rodríguez, JC | 1 |
| Ferrer, R | 1 |
| Huggard, D | 1 |
| McGrane, F | 1 |
| Lagan, N | 1 |
| Roche, E | 1 |
| Balfe, J | 1 |
| Leahy, TR | 1 |
| Franklin, O | 1 |
| Moreno, A | 1 |
| Melo, AM | 1 |
| Doherty, DG | 1 |
| Molloy, EJ | 1 |
| Zhang, WX | 1 |
| He, BM | 1 |
| Wu, Y | 1 |
| Qiao, JF | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Triple Blinded Randomized Controlled Trial of Oral Melatonin in Elevated Blood Pressure Individual (MRCTEBP)[NCT03764020] | Phase 3 | 320 participants (Anticipated) | Interventional | 2019-06-01 | Not yet recruiting | ||
| Trazodone vs. Quetiapine for the Treatment of ICU Delirium: A Prospective Observational Pilot Study[NCT05307003] | 60 participants (Anticipated) | Observational | 2023-04-01 | Recruiting | |||
| Comparison of Trazodone vs Quetiapine vs Placebo for the Treatment of ICU Delirium: A Randomized Controlled Trial (The TraQ Study)[NCT05085808] | Phase 4 | 30 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | ||
| Melatonin for Neuroprotection Following Perinatal Asphyxia[NCT02071160] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [NCT02019836] | 50 participants (Actual) | Observational [Patient Registry] | 2012-03-31 | Completed | |||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
18 reviews available for melatonin and Sepsis
| Article | Year |
|---|---|
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
Melatonin: A window into the organ-protective effects of sepsis.
Topics: Humans; Melatonin; Sepsis; Shock, Septic | 2022 |
Melatonin: A potential adjuvant therapy for septic myopathy.
Topics: Humans; Melatonin; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Quality of Life; Sepsis | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Melatonin as a potential treatment for septic cardiomyopathy.
Topics: Antioxidants; Cardiomyopathies; Cardiovascular Diseases; Humans; Melatonin; Sepsis | 2023 |
Mitochondria and Critical Illness.
Topics: Acute Lung Injury; Alarmins; Antioxidants; Cesium; Critical Illness; DNA, Mitochondrial; Humans; Mel | 2020 |
Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights.
Topics: Animals; Anti-Bacterial Agents; Humans; Inflammasomes; Melatonin; Mitogen-Activated Protein Kinases; | 2021 |
Melatonin, clock genes and mitochondria in sepsis.
Topics: Animals; Antioxidants; Circadian Rhythm; CLOCK Proteins; Humans; Melatonin; Mitochondria; Sepsis | 2017 |
Circadian dysrhythmias in the intensive care unit.
Topics: Central Nervous System Depressants; Chronobiology Disorders; Critical Illness; Humans; Intensive Car | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment.
Topics: Animals; Chronobiology Disorders; Circadian Rhythm; Critical Illness; Delirium; Humans; Intensive Ca | 2015 |
Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review.
Topics: Aflatoxins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hum | 2016 |
Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Humans; Melatonin; Mitochondria; Multiple | 2017 |
Utilizing melatonin to combat bacterial infections and septic injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Bacterial Infections; Free Radical Scavengers; Huma | 2017 |
Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin.
Topics: Animals; Asphyxia Neonatorum; Clinical Trials as Topic; Female; Free Radical Scavengers; Humans; Inf | 2009 |
Melatonin in septic shock: some recent concepts.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Humans; Inflammation; Melatoni | 2010 |
Melatonin in bacterial and viral infections with focus on sepsis: a review.
Topics: Animals; Anti-Bacterial Agents; Antiviral Agents; Bacterial Infections; Humans; Legislation, Drug; M | 2012 |
Melatonin utility in neonates and children.
Topics: Antioxidants; Child; Female; Fetal Growth Retardation; Humans; Hypoxia-Ischemia, Brain; Infant, Newb | 2012 |
Medical implications of melatonin: receptor-mediated and receptor-independent actions.
Topics: Animals; Antioxidants; Cataract; Free Radicals; Humans; Hyperoxia; Hyperthyroidism; Melatonin; Model | 2007 |
8 trials available for melatonin and Sepsis
77 other studies available for melatonin and Sepsis
| Article | Year |
|---|---|
Investigation of the effect of melatonin administration on inflammatory mediators; MMP-2, TGF-β and VEGF levels in rats with sepsis.
Topics: Animals; Disease Models, Animal; Inflammation Mediators; Matrix Metalloproteinase 2; Melatonin; Rats | 2021 |
Melatonin use and the risk of 30-day mortality among US veterans with sepsis: A retrospective study.
Topics: Hospitalization; Humans; Male; Melatonin; Retrospective Studies; Sepsis; Veterans | 2022 |
Protective role of melatonin against testicular damage caused by polymicrobial sepsis in adult rats.
Topics: Animals; Apoptosis; Hydrogen Peroxide; Male; Melatonin; Rats; Rats, Wistar; Sepsis | 2022 |
Melatonin arrests excessive inflammatory response and apoptosis in lipopolysaccharide-damaged rat liver: A deeper insight into its mechanism of action.
Topics: Animals; Antioxidants; Apoptosis; Disease Models, Animal; Lipopolysaccharides; Liver; Melatonin; Rat | 2022 |
Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Ferroptosis; Lipopolysaccharides; Malondialdeh | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Epithelial Cells; Lipopolysaccharides; Melato | 2022 |
Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway.
Topics: Animals; Inflammation; Interleukin-6; Lipopolysaccharides; Melatonin; NF-kappa B; Nuclear Proteins; | 2023 |
The relationship of melatonin concentration in preterm infants and adverse outcomes in the late neonatal period.
Topics: Bronchopulmonary Dysplasia; Humans; Infant; Infant, Newborn; Infant, Premature; Melatonin; Retinopat | 2023 |
Protection of melatonin treatment and combination with traditional antibiotics against septic myocardial injury.
Topics: AMP-Activated Protein Kinases; Anti-Bacterial Agents; Humans; Melatonin; Myocardium; Sepsis | 2023 |
Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study.
Topics: Animals; Antioxidants; Ascorbic Acid; Glutathione; Inflammation; Lung; Lung Injury; Melatonin; Oxida | 2023 |
Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis.
Topics: Animals; Endothelial Cells; Lipopolysaccharides; Melatonin; Mice; Sepsis; Signal Transduction | 2023 |
A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats.
Topics: Animals; Ascorbic Acid; Inflammation; Kidney; Male; Melatonin; Rats; Rats, Sprague-Dawley; Sepsis; S | 2023 |
Melatonin Promotes Mitochondrial Biogenesis and Mitochondrial Degradation in Hepatocytes During Sepsis.
Topics: Adenosine Triphosphate; Hepatocytes; Humans; Lipopolysaccharides; Melatonin; Mitophagy; Organelle Bi | 2023 |
Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy.
Topics: Acute Lung Injury; Animals; Inflammation; Melatonin; Mice; Mice, Inbred C57BL; Mitophagy; Sepsis | 2023 |
Daily Changes in the Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Circadian Rhythm; CLOCK Proteins; Critical Car | 2020 |
Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway.
Topics: Animals; Apoptosis; Biomarkers; Biopsy; Cytokines; Disease Models, Animal; Immunohistochemistry; Inf | 2019 |
Circadian Rhythm Disruption and Sepsis in Severe Trauma Patients.
Topics: Circadian Rhythm; Humans; Melatonin; Sepsis | 2019 |
Determination of Melatonin Deprivation Impact on Sepsis With Acute Phase Reactants.
Topics: Animals; C-Reactive Protein; Disease Models, Animal; Humans; Intensive Care Units; Light; Male; Malo | 2020 |
Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.
Topics: Animals; Apoptosis; Cardiomyopathies; Cells, Cultured; Fibronectins; Heart; Hepatocyte Growth Factor | 2020 |
Factors Disrupting Melatonin Secretion Rhythms During Critical Illness.
Topics: Academic Medical Centers; Adult; Aged; Aged, 80 and over; Arousal; Brain Diseases; Cerebral Hemorrha | 2020 |
Melatonin relieves sepsis-induced myocardial injury via regulating JAK2/STAT3 signaling pathway.
Topics: Animals; Apoptosis; Heart Injuries; Janus Kinase 2; Melatonin; Myocardial Reperfusion Injury; Rats; | 2022 |
Total Daily Production and Periodicity of Melatonin Metabolite in Critically Ill Children.
Topics: Child; Circadian Rhythm; Critical Illness; Humans; Infant; Melatonin; Prospective Studies; Sepsis | 2020 |
Melatonin Alleviates Cardiac Dysfunction Via Increasing Sirt1-Mediated Beclin-1 Deacetylation and Autophagy During Sepsis.
Topics: Acetylation; Animals; Autophagy; Beclin-1; Cells, Cultured; Disease Models, Animal; Heart Diseases; | 2021 |
Contribution of the NLRP3/IL-1β axis to impaired vasodilation in sepsis through facilitation of eNOS proteolysis and the protective role of melatonin.
Topics: Animals; Aorta; Cells, Cultured; Endothelial Cells; Humans; Interleukin-1beta; Male; Melatonin; Mese | 2021 |
Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction.
Topics: Animals; Antioxidants; Autophagy; Disease Models, Animal; Inflammation Mediators; Intestinal Mucosa; | 2021 |
Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.
Topics: Animals; Female; Heart; Inflammasomes; Melatonin; Mice; Mice, Inbred C57BL; Mutation; Myocardium; My | 2017 |
Administration of Exogenous Melatonin After the Onset of Systemic Inflammation Is Hardly Beneficial.
Topics: Animals; Endotoxemia; Inflammation; Lipopolysaccharides; Male; Melatonin; Rats; Rats, Wistar; Sepsis | 2017 |
Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice.
Topics: Animals; Antioxidants; Delayed-Action Preparations; Liver Failure, Acute; Male; Melatonin; Mice; Mic | 2017 |
Serum melatonin levels during the first seven days of severe sepsis diagnosis are associated with sepsis severity and mortality.
Topics: Aged; Comorbidity; Female; Follow-Up Studies; Hospital Mortality; Humans; Intensive Care Units; Kapl | 2018 |
Melatonin and mitochondrial dysfunction are key players in the pathophysiology of sepsis.
Topics: Humans; Melatonin; Mitochondria; Sepsis | 2018 |
Altered endotoxin responsiveness in healthy children with Down syndrome.
Topics: CD11b Antigen; Child; Child, Preschool; Down Syndrome; Escherichia coli; Female; Humans; Immunologic | 2018 |
Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice.
Topics: Animals; Apoptosis; Autophagy; Cardiotonic Agents; Heart; Heart Diseases; Male; Melatonin; Mice, Inb | 2019 |
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Topics: Acetylation; Animals; Carbazoles; Cecum; Cytokines; Enzyme Activation; Gluconeogenesis; Inflammation | 2019 |
Protective Effect of Melatonin Against Polymicrobial Sepsis Is Mediated by the Anti-bacterial Effect of Neutrophils.
Topics: Animals; Biomarkers; Cytokines; Disease Models, Animal; Extracellular Traps; Host-Pathogen Interacti | 2019 |
Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function.
Topics: Cardiomyopathies; Cardiotonic Agents; Cytoskeleton; Endoplasmic Reticulum; Endoplasmic Reticulum Str | 2019 |
Altered melatonin secretion and circadian gene expression with increased proinflammatory cytokine expression in early-stage sepsis patients.
Topics: Adult; Aged; Circadian Rhythm; Cryptochromes; Female; Gene Expression Regulation; Humans; Interleuki | 2013 |
The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.
Topics: Analysis of Variance; Animals; Antioxidants; Cytosol; Disease Models, Animal; Glutathione; Lipid Per | 2014 |
Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indenes; Interleukin-10; Interleu | 2014 |
Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis.
Topics: Animals; Base Sequence; Binding Sites; DNA Primers; Enzyme-Linked Immunosorbent Assay; Extracellular | 2014 |
Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Electron Spin Resonance Spectrosco | 2014 |
Serum melatonin levels are associated with mortality in severe septic patients.
Topics: Aged; Biomarkers; Female; Humans; Intensive Care Units; Interleukin-6; Lactic Acid; Logistic Models; | 2015 |
Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice.
Topics: Animals; Carrier Proteins; Immunity, Innate; Melatonin; Mice; Mice, Transgenic; NF-kappa B; NLR Fami | 2015 |
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Topics: Animals; Apoptosis; Brain Injuries; Cytokines; Gene Expression Regulation; Inflammation; Male; Melat | 2015 |
Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Echocardiography; Enzyme-Linked Im | 2016 |
Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.
Topics: Aging; Animals; Carrier Proteins; Gene Expression Regulation; Inflammasomes; Male; Melatonin; Mice; | 2016 |
Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network.
Topics: Animals; Antioxidants; Disease Models, Animal; Electron Transport; Electron Transport Complex III; M | 2016 |
Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model.
Topics: Anastomosis, Surgical; Animals; Antioxidants; Colon; Infusions, Parenteral; Interferon-gamma; Interl | 2016 |
Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.
Topics: Animals; Antioxidants; Biomarkers; Disease Models, Animal; Gene Expression Regulation, Enzymologic; | 2017 |
Melatonin status in pediatric intensive care patients with sepsis.
Topics: Biomarkers; Case-Control Studies; Child; Child, Preschool; Circadian Rhythm; Female; Hospital Mortal | 2012 |
Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis.
Topics: Antioxidants; Cells, Cultured; Endothelium, Vascular; Glutathione; Humans; Inflammation; Interleukin | 2011 |
Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronobiology Disorders; Circadian Rhythm; Critical Illn | 2012 |
Use of nocturnal melatonin concentration and urinary 6-sulfatoxymelatonin excretion to evaluate melatonin status in children with severe sepsis.
Topics: Biomarkers; Chemistry, Clinical; Child; Child, Preschool; Circadian Rhythm; Critical Care; Female; H | 2011 |
Antioxidants in pediatric sepsis: do not put the plough in front of the horses!.
Topics: Female; Humans; Male; Melatonin; Sepsis | 2012 |
Antioxidant potential of different melatonin-loaded nanomedicines in an experimental model of sepsis.
Topics: Animals; Antioxidants; Disease Models, Animal; Heme Oxygenase-1; Kidney; Lipid Peroxides; Liver; Lun | 2012 |
Strategies to prevent sepsis-induced intensive care unit-acquired weakness: are there any options? Commentary on "Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with surgically induced sepsis".
Topics: Animals; Antioxidants; Male; Melatonin; Oxytocin; Polyneuropathies; Sepsis | 2013 |
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis.
Topics: Animals; Antioxidants; Drug Evaluation, Preclinical; Electromyography; Lipid Peroxidation; Male; Mal | 2013 |
Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury.
Topics: Animals; Electron Transport Complex IV; Heart; Kaplan-Meier Estimate; Lactic Acid; Male; Melatonin; | 2013 |
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Cytokines; Escherichia coli; Interleukin-6; Kidney | 2013 |
Melatonin increases glutathione peroxidase activity and deformability of erythrocytes in septic rats.
Topics: Animals; Antioxidants; Erythrocytes; Glutathione Peroxidase; Melatonin; Membrane Fluidity; Rats; Sep | 2003 |
The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Multiple Organ Failure; Rats; Rats, Sprague-Dawley | 2003 |
Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder.
Topics: Analysis of Variance; Animals; Antioxidants; Carbachol; Glutathione; Ileum; Lipid Peroxidation; Malo | 2004 |
Melatonin protects from, but does not reverse, the effects of mediators of sepsis on liver bioenergetics.
Topics: Animals; Antioxidants; Cell Culture Techniques; Energy Metabolism; Hepatocytes; Hydrogen Peroxide; I | 2004 |
Lipid peroxidation and deformability of red blood cells in experimental sepsis in rats: The protective effects of melatonin.
Topics: Animals; Enzyme Inhibitors; Erythrocyte Deformability; Lipid Peroxidation; Lipopolysaccharides; Male | 2004 |
Melatonin protects against oxidative organ injury in a rat model of sepsis.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2005 |
Melatonin in critically ill patients.
Topics: Adult; Critical Care; Humans; Male; Melatonin; Respiratory Distress Syndrome; Sepsis; Sleep Wake Dis | 2005 |
Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin.
Topics: Animals; Diaphragm; Electron Transport; Glutathione; Isoenzymes; Melatonin; Mice; Mice, Inbred C57BL | 2006 |
Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.
Topics: Animals; Cecum; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Comp | 2006 |
Nocturnal melatonin concentration is correlated with illness severity in patients with septic disease.
Topics: APACHE; Germany; Humans; Melatonin; Pineal Gland; Sepsis; Severity of Illness Index | 2006 |
Melatonin restores the mitochondrial production of ATP in septic mice.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Diaphragm; Melatoni | 2006 |
The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Endotoxemia; Intestinal Mucosa; Lipid Peroxidati | 2007 |
Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Electron Transport; Melatonin; Mice; Mic | 2007 |
[Melatonin against surgical stress].
Topics: Adult; Animals; Antioxidants; Humans; Infant, Newborn; Melatonin; Myocardial Ischemia; Oxidative Str | 2007 |
Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge.
Topics: Animals; Body Weight; Cecum; Hemorrhage; Ligation; Male; Melatonin; Mice; Mice, Inbred C3H; Sepsis; | 1996 |
[The role of melatonin in the immediate postoperative period in elderly patients].
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Melatonin; Middle Aged; Neoplasms; Postoperative Comp | 2000 |
Melatonin: the next panacea?
Topics: Humans; Infant, Newborn; Melatonin; Sepsis | 2001 |
Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis.
Topics: Analysis of Variance; Case-Control Studies; Chronobiology Disorders; Female; Humans; Hypnotics and S | 2002 |
Intensive care unit sleep disruption: can the cycle be restored?
Topics: Chronobiology Disorders; Humans; Intensive Care Units; Melatonin; Sepsis | 2002 |