Page last updated: 2024-10-19

melatonin and Seizures

melatonin has been researched along with Seizures in 89 studies

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Considering that the addition of melatonin to routine anti-seizure treatment was effective in reducing the severity of epilepsy and improving sleep quality, it seems that melatonin can be useful as an adjunct therapy for EGTCS in well-defined circumstances."9.69Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial. ( Alyan NajafAbadi, S; Maghbooli, M; MalekMahmoudi, G; Molseghi, MH, 2023)
"Plasma melatonin levels increased during seizures in the study group (P < 0."7.83Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures. ( Altun, D; Arslan, M; Dabak, O; Unay, B; Vurucu, S; Yaman, H; Yesilkaya, E, 2016)
"The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats."7.81Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015)
"We examined the effect of melatonin on brain levels of amino acids and nitric oxide (NO) after pentylenetetrazole (PTZ)-induced seizures in rats."7.72Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. ( Acuña-Castroviejo, D; Bikjdaouene, L; Escames, G; Ferrer, JM; Khaldy, H; León, J; Vives, F, 2003)
"The present study investigates the mechanisms involved in the anticonvulsant effect of melatonin in maximum electroshock (MES) seizures."7.72Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures. ( Mahajan, P; Mediratta, PK; Ray, M; Reeta, Kh; Sharma, KK, 2004)
"To explore the alteration of melatonin (MT) levels in pineal, hippocampus and serum during seizure crises and electroacupuncture (EA) anti-seizures, we established a rat seizure model by microinjecting benzylpenicillin into hippocampus."7.71Melatonin might be one possible medium of electroacupuncture anti-seizures. ( Chao, DM; Chen, G; Cheng, JS, 2001)
" However, the incidence of seizures induced by potassium cyanide was significantly inhibited by preadministration of melatonin (20 mg/kg, s."7.69Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. ( Tang, HW; Yamamoto, H, 1996)
"The effect of melatonin, a potent free radical scavenger, on L-cysteine-induced seizures and lipid peroxidation was investigated in mice."7.69Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice. ( Tang, H; Yamamoto, H, 1996)
" These results suggest that bereavement apparitions are situation-specific hallucinations evoked by microseizures within sensitized temporal lobe structures; the occurrence of these microseizures might be facilitated by suppression in melatonin levels that could accompany sudden increases in geomagnetic activity."7.67Increased geomagnetic activity and the occurrence of bereavement hallucinations: evidence for melatonin-mediated microseizuring in the temporal lobe? ( Persinger, MA, 1988)
"Clinical evaluation of seizure frequency, Chalfont-National Hospital seizure severity scale (NHS3), Pittsburgh sleep quality index (PSQI), quality of life in epilepsy inventory, Epworth sleepiness scale (ESS), and biochemical estimation of serum neuron-specific enolase (NSE) and glutathione reductase were done at baseline and compared with follow-up at 8 weeks."7.01Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial. ( Jena, M; Jha, M; Maiti, R; Mishra, A; Mishra, BR; Verma, N, 2021)
"Diurnal seizures decreased significantly with melatonin compared with placebo (P = ."6.77Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. ( Garty, BZ; Goldberg-Stern, H; Oren, H; Peled, N, 2012)
"There was also significant reduction in seizure severity."6.75Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010)
"In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy."6.47Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011)
"Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death."5.72The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022)
"Considering that the addition of melatonin to routine anti-seizure treatment was effective in reducing the severity of epilepsy and improving sleep quality, it seems that melatonin can be useful as an adjunct therapy for EGTCS in well-defined circumstances."5.69Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial. ( Alyan NajafAbadi, S; Maghbooli, M; MalekMahmoudi, G; Molseghi, MH, 2023)
"Epilepsy is a chronic neurological disease with recurrent seizures."5.62Melatonin and Epilepsy. ( Vasileva, Z, 2021)
"Furthermore, the melatonin-pretreated seizure rats (Mel + RS) exhibited a significantly upregulated expression of calcium/calmodulin-dependent protein kinase II α (CaMKIIα), acetyl-Coenzyme A acetyltransferase 1 (ACAT1), ZnT-1, metallothionein 1 (MT-1), nSMase and Cathepsin-E, compared with the RS rats."5.42Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin. ( Feng, X; Ni, H; Sun, BL; Sun, Q; Tian, T, 2015)
"The seizures were induced by keeping the rats in 45 °C water and the experiments were performed in two steps."5.42Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures. ( Aydin, L; Gundogan, NU; Yazici, C, 2015)
"in patients with diurnal seizures (occurring mainly in the morning) may suggest proconvulsive effect of this hormone."5.40Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report. ( Czuczwar, SJ; Gołba, A; Motta, E; Norman, R; Ostrowska, Z; Sołtyk, J; Woźnik, G, 2014)
"Epilepsy is the most common neurological disorder, approximately 1% of the population worldwide have epilepsy."5.35Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis. ( Amado, D; Arida, RM; Cavalheiro, EA; Colugnati, DB; de Lima, E; Naffah-Mazzacoratti, Mda G; Scorza, FA, 2008)
"These seizures were completely abolished by the simultaneous administration of melatonin (20 mg/kg, ip), a potent scavenger of hydroxyl radical."5.31Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. ( Mohanan, PV; Yamamoto, HA, 2002)
"Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant."5.30Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998)
"The melatonin plasma levels were low for the chronological age but appropriate for the pubertal status, making a causal relationship between lowered melatonin plasma levels and precocious puberty possible."5.29Precocious puberty and decreased melatonin secretion due to a hypothalamic hamartoma. ( Commentz, JC; Helmke, K, 1995)
" Last, CPEB4-deficient mice showed altered circadian function, including altered melatonin blood levels and altered clustering of spontaneous seizures during the day."4.31CPEB4-CLOCK crosstalk during temporal lobe epilepsy. ( Alves, M; Auer, T; Beausang, A; Brennan, GP; Brett, FM; Carracedo-Rodríguez, G; Cryan, J; de Diego-Garcia, L; Delanty, N; Engel, T; Farrell, MA; Gil, B; Henshall, DC; Lau, K; Lucas, JJ; Martin-Gil, A; Mendez, R; Menendez-Mendez, A; Mitra, M; O'Brien, DF; Ollà, I; Parras, A; Villalba-Benito, L, 2023)
"Studies about the relationship between epileptic seizures (ESs) and melatonin are limited in children and have been performed in heterogeneous patient groups and with different methods."3.96The relationship between epileptic seizure and melatonin in children. ( Aksu Uzunhan, T; Kacar, A; Kucur, M; Saltik, S; Tarcin, G, 2020)
"Plasma melatonin levels increased during seizures in the study group (P < 0."3.83Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures. ( Altun, D; Arslan, M; Dabak, O; Unay, B; Vurucu, S; Yaman, H; Yesilkaya, E, 2016)
"The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats."3.81Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015)
"Phenobarbital is the most commonly utilized drug for neonatal seizures."3.79Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats. ( Duckles, A; Forcelli, PA; Gale, K; Kondratyev, A; Soper, C, 2013)
" This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures."3.77The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011)
" This study investigated the effect of melatonin on biphasic modulation of seizure susceptibility by morphine, in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures."3.74Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2007)
" In the present study, the involvement of NO pathway in the anticonvulsant effect of melatonin in pentylenetetrazole (PTZ)-induced clonic seizures was investigated in mice."3.73Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2006)
"We examined the effect of melatonin on brain levels of amino acids and nitric oxide (NO) after pentylenetetrazole (PTZ)-induced seizures in rats."3.72Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. ( Acuña-Castroviejo, D; Bikjdaouene, L; Escames, G; Ferrer, JM; Khaldy, H; León, J; Vives, F, 2003)
"The present study investigates the mechanisms involved in the anticonvulsant effect of melatonin in maximum electroshock (MES) seizures."3.72Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures. ( Mahajan, P; Mediratta, PK; Ray, M; Reeta, Kh; Sharma, KK, 2004)
"To explore the alteration of melatonin (MT) levels in pineal, hippocampus and serum during seizure crises and electroacupuncture (EA) anti-seizures, we established a rat seizure model by microinjecting benzylpenicillin into hippocampus."3.71Melatonin might be one possible medium of electroacupuncture anti-seizures. ( Chao, DM; Chen, G; Cheng, JS, 2001)
" The results support the hypothesis that suppression of the nocturnal concentrations of the endogenous anticonvulsant melatonin by sudden increases in geomagnetic activity may encourage fatal cardiac arrhythmias by uncoupling the insular/amygdaloid-paraventricular hypothalamic-solitary nucleus pathways."3.69Sudden unexpected death in epileptics following sudden, intense, increases in geomagnetic activity: prevalence of effect and potential mechanisms. ( Persinger, MA; Psych, C, 1995)
" However, the incidence of seizures induced by potassium cyanide was significantly inhibited by preadministration of melatonin (20 mg/kg, s."3.69Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. ( Tang, HW; Yamamoto, H, 1996)
"The effect of melatonin, a potent free radical scavenger, on L-cysteine-induced seizures and lipid peroxidation was investigated in mice."3.69Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice. ( Tang, H; Yamamoto, H, 1996)
" These results suggest that bereavement apparitions are situation-specific hallucinations evoked by microseizures within sensitized temporal lobe structures; the occurrence of these microseizures might be facilitated by suppression in melatonin levels that could accompany sudden increases in geomagnetic activity."3.67Increased geomagnetic activity and the occurrence of bereavement hallucinations: evidence for melatonin-mediated microseizuring in the temporal lobe? ( Persinger, MA, 1988)
"Clinical evaluation of seizure frequency, Chalfont-National Hospital seizure severity scale (NHS3), Pittsburgh sleep quality index (PSQI), quality of life in epilepsy inventory, Epworth sleepiness scale (ESS), and biochemical estimation of serum neuron-specific enolase (NSE) and glutathione reductase were done at baseline and compared with follow-up at 8 weeks."3.01Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial. ( Jena, M; Jha, M; Maiti, R; Mishra, A; Mishra, BR; Verma, N, 2021)
"Diurnal seizures decreased significantly with melatonin compared with placebo (P = ."2.77Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. ( Garty, BZ; Goldberg-Stern, H; Oren, H; Peled, N, 2012)
"There was also significant reduction in seizure severity."2.75Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010)
"Epilepsy is a result of unprovoked, uncontrollable, and repetitive outburst of abnormal and excessive electrical discharges, known as seizures, in the neurons."2.72Melatonin as an Antiepileptic Molecule: Therapeutic Implications via Neuroprotective and Inflammatory Mechanisms. ( Akyuz, E; Arulsamy, A; Kullu, I; Shaikh, MF, 2021)
"Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect."2.48Melatonin utility in neonates and children. ( Chen, YC; Huang, LT; Sheen, JM; Tain, YL, 2012)
"In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy."2.47Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011)
"Melatonin is a neurohormone naturally found in humans."2.44Neurobiological effects of melatonin as related to cancer. ( Hoang, BX; Levine, SA; Pham, PT; Shaw, DG, 2007)
"These include sleep disorders with a specific relationship to epilepsy, the influences of sleep and sleep deprivation on interictal epileptiform discharges, detrimental effects of seizures on sleep, and the effects (good and bad) of epilepsy treatments on sleep."2.42Sleep-related epilepsy. ( Bazil, CW, 2003)
"Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death."1.72The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022)
"Epilepsy is a chronic neurological disease with recurrent seizures."1.62Melatonin and Epilepsy. ( Vasileva, Z, 2021)
"We found melatonin suppressed seizure-like behavior by using zebrafish regular locomotor assays."1.62Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. ( Gao, D; Jin, M; Li, N; Liu, K; Mou, L; Ren, Q; Sik, A; Zhang, M; Zhang, S, 2021)
"On the 15th day, the seizure was induced (except the control group) by intraperitoneal injection of PTZ."1.62Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress. ( Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Karimi, MY; Mehrzadi, S, 2021)
"The seizures were induced by keeping the rats in 45 °C water and the experiments were performed in two steps."1.42Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures. ( Aydin, L; Gundogan, NU; Yazici, C, 2015)
"Furthermore, the melatonin-pretreated seizure rats (Mel + RS) exhibited a significantly upregulated expression of calcium/calmodulin-dependent protein kinase II α (CaMKIIα), acetyl-Coenzyme A acetyltransferase 1 (ACAT1), ZnT-1, metallothionein 1 (MT-1), nSMase and Cathepsin-E, compared with the RS rats."1.42Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin. ( Feng, X; Ni, H; Sun, BL; Sun, Q; Tian, T, 2015)
"Anxiety and seizures are closely similar neurobehavioral disorders and are regulated by limbic system."1.40Differential neuromodulatory role of NO in anxiety and seizures: an experimental study. ( Gulati, K; Ray, A, 2014)
"in patients with diurnal seizures (occurring mainly in the morning) may suggest proconvulsive effect of this hormone."1.40Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report. ( Czuczwar, SJ; Gołba, A; Motta, E; Norman, R; Ostrowska, Z; Sołtyk, J; Woźnik, G, 2014)
"Melatonin has been mainly used for alleviating some disorders related with insomnia and circadian rhythmicity."1.39Behavioural actions of two new 1-N substituted analogues of melatonin. ( Bustamante-García, R; Lira-Rocha, AS; Naranjo-Rodríguez, EB; Ortiz-Osornio, A; Picazo, O, 2013)
"Oxidative stress usually accompanies seizures."1.38An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin. ( Deykun, K; Krýsl, D; Mareš, J; Pometlová, M; Rokyta, R, 2012)
"In the PTZ-induced seizure model, agomelatine (at 25 or 50mg/kg) showed a significant increase in latency to convulsion, and agomelatine (at 50 or 75 mg/kg) also increased significantly time until death."1.38Anticonvulsant effects of agomelatine in mice. ( Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Sousa, FC; do Vale, OC; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM; Viana, GS, 2012)
"Although melatonin influences seizure thresholds, the relationship is complex."1.37Light therapy as a treatment for epilepsy. ( Baxendale, SA, 2011)
" However, in both groups chronic administration of melatonin (20mg/kg) reversed the effect of LD cycle alteration on CST."1.35Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2008)
"Epilepsy is the most common neurological disorder, approximately 1% of the population worldwide have epilepsy."1.35Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis. ( Amado, D; Arida, RM; Cavalheiro, EA; Colugnati, DB; de Lima, E; Naffah-Mazzacoratti, Mda G; Scorza, FA, 2008)
" Theophylline, a re-emerging drug for the treatment of obstructive airway disease, has a narrow therapeutic index which precludes its safe use."1.34Free radicals and theophylline neurotoxicity : an experimental study. ( Gulati, K; Ray, A; Vijayan, VK, 2007)
"Aminophylline (50-250 mg/kg) induced convulsions and mortality in mice in a dose-dependent manner."1.33Possible role of free radicals in theophylline-induced seizures in mice. ( Gulati, K; Pal, G; Ray, A; Vijayan, VK, 2005)
"The damage of mtDNA and seizures induced by potassium cyanide were abolished by the pre-injection of melatonin (20 mg/kg)."1.31Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro. ( Mohanan, PV; Yamamoto, HA, 2002)
"These seizures were completely abolished by the simultaneous administration of melatonin (20 mg/kg, ip), a potent scavenger of hydroxyl radical."1.31Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. ( Mohanan, PV; Yamamoto, HA, 2002)
"Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant."1.30Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998)
"The melatonin plasma levels were low for the chronological age but appropriate for the pubertal status, making a causal relationship between lowered melatonin plasma levels and precocious puberty possible."1.29Precocious puberty and decreased melatonin secretion due to a hypothalamic hamartoma. ( Commentz, JC; Helmke, K, 1995)
"To assess whether electrically induced seizures are indeed required for the appearance of the blunted pineal response to isoproterenol, pineal and serum melatonin levels were measured after isoproterenol stimulation in rats treated with ECS (80 mA, 0."1.29Role of seizure activity in the decreased pineal response to isoproterenol in rats chronically treated with electroconvulsive shock. ( Amaro, S; d'Istria, M; De Luca, B; Maj, M; Monteleone, P; Serino, I, 1994)
"Locomotor activity, analgesia, and seizure susceptibility were maximal at the beginning of the scotophase and minimal at noon."1.28Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism. ( Burin, LJ; Cardinali, DP; De Brito Sánchez, MG; Escolar, E; Fernández Duque, D; Golombek, DA, 1992)
"Convulsions were induced by administering 3-mercaptopropionic acid (3-MP)."1.28Time-dependent anticonvulsant activity of melatonin in hamsters. ( Burin, L; Cardinali, DP; De Brito Sánchez, MG; Fernández Duque, D; Golombek, DA, 1992)
"During the seizure-free interval, the circadian profile of serum prolactin was lower in female patients than in healthy women."1.28Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels. ( Bauer, J; Rao, ML; Stefan, H, 1989)
"Melatonin-treated pinealectomized animals exhibited fewer seizures than did pinealectomized animals that did not receive melatonin."1.26Antiepileptic effects of melatonin in the pinealectomized Mongolian gerbil. ( Philo, RC; Rudeen, PK; Symmes, SK, 1980)
"In contrast neither the seizure threshold raising or sedative effect of melatonin (200 mg/kg) was reversed by Ro 15-1788."1.26Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663. ( Cowen, PJ; Green, AR; Nutt, DJ, 1982)
"Included in the convulsions are wild running, tonic-clonic activity, and occasionally death."1.26Characterization of pinealectomy induced convulsions in the Mongolian gerbil (Meriones unguiculatus). ( Philo, R; Reiter, RJ, 1978)

Research

Studies (89)

TimeframeStudies, this research(%)All Research%
pre-199013 (14.61)18.7374
1990's21 (23.60)18.2507
2000's19 (21.35)29.6817
2010's24 (26.97)24.3611
2020's12 (13.48)2.80

Authors

AuthorsStudies
Gunia-Krzyżak, A1
Żelaszczyk, D1
Rapacz, A1
Żesławska, E1
Waszkielewicz, AM1
Pańczyk, K1
Słoczyńska, K1
Pękala, E1
Nitek, W1
Filipek, B1
Marona, H1
Ren, Q1
Gao, D1
Mou, L1
Zhang, S1
Zhang, M1
Li, N1
Sik, A1
Jin, M1
Liu, K1
Hosseinzadeh, A2
Dehdashtian, E2
Jafari-Sabet, M1
Mehrzadi, S2
Vasileva, Z1
Maghbooli, M1
Alyan NajafAbadi, S1
MalekMahmoudi, G1
Molseghi, MH1
de Diego-Garcia, L1
Brennan, GP1
Auer, T1
Menendez-Mendez, A1
Parras, A1
Martin-Gil, A1
Mitra, M1
Ollà, I1
Villalba-Benito, L1
Gil, B1
Alves, M1
Lau, K1
Delanty, N1
Beausang, A1
Cryan, J1
Brett, FM1
Farrell, MA1
O'Brien, DF1
Mendez, R1
Carracedo-Rodríguez, G1
Henshall, DC1
Lucas, JJ1
Engel, T1
Campbell, S1
Otten, H1
Anand, V1
Tchekalarova, J2
Angelova, VT2
Todorova, N2
Andreeva-Gateva, P2
Rangelov, M2
Tarcin, G2
Aksu Uzunhan, T1
Kacar, A1
Kucur, M1
Saltik, S1
Kennaway, DJ1
Verma, N1
Maiti, R1
Mishra, BR1
Jha, M1
Jena, M1
Mishra, A1
Akyuz, E1
Kullu, I1
Arulsamy, A1
Shaikh, MF1
Hemati, K1
Karimi, MY1
Fatemi, I1
Won, J1
Jin, Y1
Choi, J1
Park, S1
Lee, TH1
Lee, SR2
Chang, KT1
Hong, Y1
Dangalov, M1
Kondeva-Burdina, M1
Karabeliov, V1
Shivachev, B1
Forcelli, PA1
Soper, C1
Duckles, A1
Gale, K1
Kondratyev, A1
Motta, E1
Czuczwar, SJ2
Ostrowska, Z1
Gołba, A1
Sołtyk, J1
Norman, R1
Woźnik, G1
Gulati, K4
Ray, A4
Ni, H2
Sun, Q2
Tian, T2
Feng, X2
Sun, BL2
Choopankareh, S1
Vafaee, F1
Shafei, MN1
Sadeghnia, HR1
Salarinia, R1
Zarepoor, L1
Hosseini, M1
Aydin, L1
Gundogan, NU1
Yazici, C1
Dabak, O1
Altun, D1
Arslan, M1
Yaman, H1
Vurucu, S1
Yesilkaya, E1
Unay, B1
Mosińska, P1
Socała, K1
Nieoczym, D1
Laudon, M1
Storr, M1
Fichna, J1
Wlaź, P1
Tahsili-Fahadan, P3
Yahyavi-Firouz-Abadi, N3
Riazi, K3
Ghahremani, MH3
Dehpour, AR4
Elkhayat, HA1
Hassanein, SM1
Tomoum, HY1
Abd-Elhamid, IA1
Asaad, T1
Elwakkad, AS1
Anderson, G1
Rodriguez, M1
Baxendale, SA1
Banach, M1
Gurdziel, E1
Jędrych, M1
Borowicz, KK2
Deretzi, G1
Kountouras, J1
Gavalas, E1
Polyzos, SA1
Zavos, C1
Klonizakis, P1
Vardaka, E1
Skendros, P1
Katsinelos, P1
Giartza-Taxidou, E1
Kyriakou, P1
Moezi, L1
Shafaroodi, H1
Hojati, A1
Mareš, J1
Pometlová, M1
Deykun, K1
Krýsl, D1
Rokyta, R1
Chen, YC1
Tain, YL1
Sheen, JM1
Huang, LT1
Goldberg-Stern, H1
Oren, H1
Peled, N1
Garty, BZ1
Aguiar, CC1
Almeida, AB1
Araújo, PV1
Vasconcelos, GS1
Chaves, EM1
do Vale, OC1
Macêdo, DS1
de Sousa, FC1
Viana, GS2
Vasconcelos, SM1
Bustamante-García, R1
Naranjo-Rodríguez, EB1
Lira-Rocha, AS1
Ortiz-Osornio, A1
Picazo, O1
Yamamoto, HA2
Mohanan, PV2
Bazil, CW1
Srivastava, AK1
Malhotra, J1
Gupta, YK1
Bikjdaouene, L1
Escames, G2
León, J1
Ferrer, JM1
Khaldy, H1
Vives, F1
Acuña-Castroviejo, D3
Ray, M1
Mediratta, PK1
Reeta, Kh1
Mahajan, P1
Sharma, KK1
Pal, G1
Vijayan, VK2
Chakraborti, A1
Scorza, FA1
Colugnati, DB1
Arida, RM1
de Lima, E1
Naffah-Mazzacoratti, Mda G1
Cavalheiro, EA1
Amado, D1
Molina-Carballo, A2
Muñoz-Hoyos, A2
Sánchez-Forte, M2
Uberos-Fernández, J1
Moreno-Madrid, F1
Hoang, BX1
Shaw, DG1
Pham, PT1
Levine, SA1
Green, AR1
Nutt, DJ1
Cowen, PJ1
Albertson, TE1
Peterson, SL1
Stark, LG1
Lakin, ML1
Winters, WD1
Rudeen, PK1
Philo, RC1
Symmes, SK1
Persinger, MA3
Psych, C1
Monteleone, P1
Amaro, S1
De Luca, B1
d'Istria, M1
Serino, I1
Maj, M1
Yamamoto, H3
Tang, HW2
Commentz, JC1
Helmke, K1
Champney, TH2
Hanneman, WH1
Legare, ME1
Appel, K1
Tang, H1
Manev, H2
Uz, T2
Kharlamov, A1
Joo, JY1
McArthur, AJ1
Budden, SS1
Lapin, IP1
Mirzaev, SM1
Ryzov, IV1
Oxenkrug, GF1
Sheldon, SH1
Wurtman, RJ1
Zhdanova, II1
Martin-Medina, E1
Reiter, RJ5
Molina-Font, JA1
Mevissen, M1
Ebert, U1
Kamiński, R1
Gasior, M1
Kleinrok, Z1
Lee, YK1
Kim, CY1
Chao, DM1
Chen, G1
Cheng, JS1
Chatterjie, N1
Alexander, G1
Wang, H1
Costa-Lotufo, LV1
Fonteles, MM1
Lima, IS1
de Oliveira, AA1
Nascimento, VS1
de Bruin, VM1
Brailowsky, S1
Fariello, RG1
Bubenik, GA1
Brown, GM1
Grota, LJ1
Philo, R1
Vaughan, MK1
Vaughan, GM1
Blask, DE1
Champney, JA1
Golombek, DA2
Escolar, E1
Burin, LJ1
De Brito Sánchez, MG2
Fernández Duque, D2
Cardinali, DP2
Burin, L1
Dakshinamurti, K1
Paulose, CS1
Viswanathan, M1
Siow, YL1
Sharma, SK1
Bolster, B1
Rao, ML1
Stefan, H1
Bauer, J1
Erlich, SS1
Apuzzo, ML1
Morgan, WW1
Talbot, JA1
Izumi, K1
Donaldson, J1
Minnich, J1
Barbeau, A1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Melatonin Supplementation on Sleep and Health of Children With Cerebral Palsy[NCT04392063]40 participants (Actual)Interventional2016-06-30Completed
Melatonin for Neuroprotection Following Perinatal Asphyxia[NCT02071160]Phase 1/Phase 245 participants (Actual)Interventional2012-01-31Completed
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197]Phase 4104 participants (Actual)Interventional2018-08-06Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for melatonin and Seizures

ArticleYear
Melatonin as an Antiepileptic Molecule: Therapeutic Implications via Neuroprotective and Inflammatory Mechanisms.
    ACS chemical neuroscience, 2021, 04-21, Volume: 12, Issue:8

    Topics: Anti-Inflammatory Agents; Anticonvulsants; Epilepsy; Humans; Melatonin; Seizures

2021
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.
    International journal of molecular sciences, 2017, Jun-20, Volume: 18, Issue:6

    Topics: Anxiety; Autism Spectrum Disorder; Circadian Clocks; Circadian Rhythm; Fragile X Mental Retardation

2017
Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin.
    European journal of neurology, 2011, Volume: 18, Issue:5

    Topics: Anticonvulsants; Comorbidity; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interl

2011
Melatonin in experimental seizures and epilepsy.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:1

    Topics: Animals; Anticonvulsants; Antioxidants; Child; Disease Models, Animal; Epilepsy; Humans; Melatonin;

2011
Melatonin utility in neonates and children.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2012, Volume: 111, Issue:2

    Topics: Antioxidants; Child; Female; Fetal Growth Retardation; Humans; Hypoxia-Ischemia, Brain; Infant, Newb

2012
Sleep-related epilepsy.
    Current neurology and neuroscience reports, 2003, Volume: 3, Issue:2

    Topics: Anticonvulsants; Electric Stimulation Therapy; Electroencephalography; Epilepsy; Humans; Melatonin;

2003
Current trends in nitric oxide research.
    Cellular and molecular biology (Noisy-le-Grand, France), 2007, Apr-15, Volume: 53, Issue:1

    Topics: Animals; Biomedical Research; Cell Adhesion Molecules; Cytokines; Estrogens; Gene Expression; Heat-S

2007
Neurobiological effects of melatonin as related to cancer.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2007, Volume: 16, Issue:6

    Topics: Aging; Antineoplastic Agents; Biological Clocks; Clinical Trials as Topic; Drug Evaluation, Preclini

2007
Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence.
    Journal of child neurology, 1998, Volume: 13, Issue:10

    Topics: Animals; Anticonvulsants; Child Development; Circadian Rhythm; Free Radicals; Humans; Infant, Newbor

1998
Neurobiology of pyridoxine.
    Annals of the New York Academy of Sciences, 1990, Volume: 585

    Topics: Animals; Brain; Endocrine Glands; Hypothalamus; Melatonin; Nervous System; Pineal Gland; Pituitary G

1990
The pineal gland: anatomy, physiology, and clinical significance.
    Journal of neurosurgery, 1985, Volume: 63, Issue:3

    Topics: Analgesia; Animals; Brain Neoplasms; Circadian Rhythm; Depression; Electroencephalography; Humans; H

1985
Comparative physiology: pineal gland.
    Annual review of physiology, 1973, Volume: 35

    Topics: Aminobutyrates; Animals; Brain; Cricetinae; Electroencephalography; Electrophysiology; Female; Folli

1973

Trials

5 trials available for melatonin and Seizures

ArticleYear
Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial.
    Brain and behavior, 2023, Volume: 13, Issue:2

    Topics: Adult; Anticonvulsants; Cross-Sectional Studies; Epilepsy; Humans; Melatonin; Seizures; Sleep Qualit

2023
Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial.
    Journal of neuroscience research, 2021, Volume: 99, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Epilepsy, Genera

2021
Melatonin and sleep-related problems in children with intractable epilepsy.
    Pediatric neurology, 2010, Volume: 42, Issue:4

    Topics: Adolescent; Bruxism; Child; Child, Preschool; Epilepsy; Female; Humans; Hypnotics and Sedatives; Mal

2010
Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study.
    Journal of child neurology, 2012, Volume: 27, Issue:12

    Topics: Actigraphy; Adolescent; Adult; Antioxidants; Child; Cross-Over Studies; Epilepsy; Female; Humans; Ma

2012
Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment.
    Developmental medicine and child neurology, 1998, Volume: 40, Issue:3

    Topics: Anticonvulsants; Antioxidants; Child; Cross-Over Studies; Double-Blind Method; Female; Humans; Melat

1998

Other Studies

72 other studies available for melatonin and Seizures

ArticleYear
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo

2017
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish.
    European journal of pharmacology, 2021, Dec-05, Volume: 912

    Topics: Animals; Anticonvulsants; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy; Gene

2021
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice.
    Central nervous system agents in medicinal chemistry, 2022, Volume: 22, Issue:2

    Topics: Animals; Anticonvulsants; Cholecalciferol; Disease Models, Animal; Epilepsy; Melatonin; Mice; Pentyl

2022
Melatonin and Epilepsy.
    Folia medica, 2021, Dec-31, Volume: 63, Issue:6

    Topics: Animals; Anticonvulsants; Circadian Rhythm; Epilepsy; Humans; Melatonin; Seizures

2021
CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
    Epilepsia, 2023, Volume: 64, Issue:10

    Topics: Animals; CLOCK Proteins; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Male

2023
CYP450 Genetic Polymorphisms: Generalized Tonic-Clonic Seizure after Intentional Fluoxetine and Melatonin Overdose.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2023, Volume: 76, Issue:7

    Topics: Cytochrome P-450 Enzyme System; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fluo

2023
Evaluation of the anticonvulsant effect of novel melatonin derivatives in the intravenous pentylenetetrazol seizure test in mice.
    European journal of pharmacology, 2019, Nov-15, Volume: 863

    Topics: Administration, Intravenous; Animals; Anticonvulsants; Drug Interactions; Male; Melatonin; Mice; Mol

2019
The relationship between epileptic seizure and melatonin in children.
    Epilepsy & behavior : E&B, 2020, Volume: 112

    Topics: Child; Electroencephalography; Epilepsy; Humans; Melatonin; Seizures; Status Epilepticus

2020
Response to Dr. Kennaway.
    Epilepsy & behavior : E&B, 2021, Volume: 114, Issue:Pt A

    Topics: Child; Epilepsy; Humans; Melatonin; Seizures

2021
Melatonin measurement in epilepsy; are the assays letting us down?
    Epilepsy & behavior : E&B, 2021, Volume: 114, Issue:Pt A

    Topics: Child; Epilepsy; Humans; Melatonin; Seizures

2021
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress.
    Central nervous system agents in medicinal chemistry, 2021, Volume: 21, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Melatonin; Mice; Oxidative Stress; Pentylene

2021
Discovery of novel indole-based aroylhydrazones as anticonvulsants: Pharmacophore-based design.
    Bioorganic chemistry, 2019, Volume: 90

    Topics: Animals; Anticonvulsants; Drug Design; Drug Discovery; Hepatocytes; Hydrazones; Male; Melatonin; Mic

2019
Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats.
    Epilepsy research, 2013, Volume: 107, Issue:3

    Topics: Animals; Animals, Newborn; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Drug T

2013
Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:3

    Topics: Adult; Circadian Rhythm; Epilepsy; Female; Humans; Male; Melatonin; Middle Aged; Saliva; Seizures; Y

2014
Differential neuromodulatory role of NO in anxiety and seizures: an experimental study.
    Nitric oxide : biology and chemistry, 2014, Dec-01, Volume: 43

    Topics: Aminophylline; Animals; Anxiety; Arginine; Enzyme Inhibitors; Male; Malondialdehyde; Melatonin; Neur

2014
Prophylactic treatment with melatonin before recurrent neonatal seizures: Effects on long-term neurobehavioral changes and the underlying expression of metabolism-related genes in rat hippocampus and cerebral cortex.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 133

    Topics: Acetyl-CoA C-Acetyltransferase; Animals; Animals, Newborn; Behavior, Animal; Calcium-Calmodulin-Depe

2015
Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Animals; Animals, Newborn; Central Nervous System Depressants; Gene Expression Regulation; Hippocamp

2015
Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:4

    Topics: Animals; Antioxidants; Biological Availability; Brain; Central Nervous System Depressants; Disease M

2015
Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures.
    Epilepsy research, 2015, Volume: 118

    Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Administration Schedule; Hy

2015
Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures.
    Pediatric neurology, 2016, Volume: 57

    Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cir

2016
Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice.
    Behavioural brain research, 2016, 07-01, Volume: 307

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ele

2016
Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice.
    Epilepsy research, 2008, Volume: 82, Issue:1

    Topics: Animals; Circadian Rhythm; Disease Susceptibility; Male; Melatonin; Mice; Pentylenetetrazole; Photop

2008
Light therapy as a treatment for epilepsy.
    Medical hypotheses, 2011, Volume: 76, Issue:5

    Topics: Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Humans; Light; Melatonin; Models, Biological; Mo

2011
Multiple sclerosis and seizures: possible role of Helicobacter pylori.
    European journal of neurology, 2011, Volume: 18, Issue:9

    Topics: Anticonvulsants; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-18; Melatonin; Multiple S

2011
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
    Epilepsy & behavior : E&B, 2011, Volume: 22, Issue:2

    Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela

2011
An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin.
    Epilepsy & behavior : E&B, 2012, Volume: 23, Issue:3

    Topics: Analysis of Variance; Animals; Antioxidants; Automatism; Blood-Brain Barrier; Convulsants; Disease M

2012
Anticonvulsant effects of agomelatine in mice.
    Epilepsy & behavior : E&B, 2012, Volume: 24, Issue:3

    Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Female; Melaton

2012
Behavioural actions of two new 1-N substituted analogues of melatonin.
    Behavioural brain research, 2013, Jan-01, Volume: 236, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antioxidants; Anxiety; Behavior, Animal; Diazepam; Do

2013
Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro.
    Toxicology, 2002, Sep-30, Volume: 179, Issue:1-2

    Topics: Animals; Brain Chemistry; DNA Damage; DNA, Mitochondrial; Electrophoresis, Agar Gel; Free Radical Sc

2002
Adenosine receptors do not mediate the melatonin protection against pentylenetetrazole induced seizures in rats.
    Neurobiology (Budapest, Hungary), 2001, Volume: 9, Issue:3-4

    Topics: Adenosine; Animals; Anticonvulsants; Male; Melatonin; Pentylenetetrazole; Purinergic P1 Receptor Ant

2001
Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures.
    Journal of pineal research, 2003, Volume: 35, Issue:1

    Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Male; Melatonin; Nitric Oxide; Pentylenet

2003
Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures.
    Methods and findings in experimental and clinical pharmacology, 2004, Volume: 26, Issue:3

    Topics: Animals; Anticonvulsants; Electroshock; GABA-A Receptor Agonists; Male; Melatonin; Mice; Receptors,

2004
Possible role of free radicals in theophylline-induced seizures in mice.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:1

    Topics: Aminophylline; Animals; Bronchodilator Agents; Female; Free Radicals; Male; Melatonin; Mice; NG-Nitr

2005
Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice.
    Epilepsy research, 2006, Volume: 68, Issue:2

    Topics: Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Drug Therapy, Com

2006
Free radicals and theophylline neurotoxicity : an experimental study.
    Cellular and molecular biology (Noisy-le-Grand, France), 2007, May-30, Volume: 53, Issue:5

    Topics: alpha-Tocopherol; Aminophylline; Animals; Antioxidants; Arginine; Ascorbic Acid; Dose-Response Relat

2007
Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway.
    Epilepsy research, 2007, Volume: 75, Issue:2-3

    Topics: Animals; Anticonvulsants; Antioxidants; Convulsants; Dose-Response Relationship, Drug; Electric Stim

2007
Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis.
    Medical hypotheses, 2008, Volume: 70, Issue:3

    Topics: Cardiotonic Agents; Death, Sudden; Epilepsy; Humans; Melatonin; Models, Biological; Risk Factors; Se

2008
Melatonin increases following convulsive seizures may be related to its anticonvulsant properties at physiological concentrations.
    Neuropediatrics, 2007, Volume: 38, Issue:3

    Topics: Adolescent; Analysis of Variance; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant;

2007
Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.
    Psychopharmacology, 1982, Volume: 78, Issue:3

    Topics: Animals; Arousal; Benzodiazepinones; Brain; Diazepam; Dose-Response Relationship, Drug; Exploratory

1982
The anticonvulsant properties of melatonin on kindled seizures in rats.
    Neuropharmacology, 1981, Volume: 20, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Melatonin; Naloxone; Penty

1981
Antiepileptic effects of melatonin in the pinealectomized Mongolian gerbil.
    Epilepsia, 1980, Volume: 21, Issue:2

    Topics: Animals; Drug Implants; Gerbillinae; Male; Melatonin; Pineal Gland; Seizures

1980
Sudden unexpected death in epileptics following sudden, intense, increases in geomagnetic activity: prevalence of effect and potential mechanisms.
    International journal of biometeorology, 1995, Volume: 38, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Death, Sudden; Electromagnetic Phenomena; Epilepsy; Geography; Humans

1995
Role of seizure activity in the decreased pineal response to isoproterenol in rats chronically treated with electroconvulsive shock.
    Psychiatry research, 1994, Volume: 53, Issue:2

    Topics: Animals; Electroshock; Isoproterenol; Male; Melatonin; Norepinephrine; Pineal Gland; Rats; Rats, Spr

1994
Average diurnal changes in melatonin levels are associated with hourly incidence of bereavement apparitions: support for the hypothesis of temporal (limbic) lobe microseizuring.
    Perceptual and motor skills, 1993, Volume: 76, Issue:2

    Topics: Adrenocorticotropic Hormone; Bereavement; Circadian Rhythm; Death; Female; Humans; Male; Melatonin;

1993
Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice.
    Toxicology letters, 1996, Volume: 87, Issue:1

    Topics: Animals; Antidotes; Brain; Dose-Response Relationship, Drug; Injections, Subcutaneous; Lethal Dose 5

1996
Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice.
    Neuroscience letters, 1996, Mar-29, Volume: 207, Issue:2

    Topics: Animals; Cyanides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Lipid Peroxidation; Male;

1996
Precocious puberty and decreased melatonin secretion due to a hypothalamic hamartoma.
    Hormone research, 1995, Volume: 44, Issue:6

    Topics: Female; Gonadotropin-Releasing Hormone; Hamartoma; Humans; Hypothalamic Neoplasms; Infant; Magnetic

1995
Acute and chronic effects of melatonin as an anticonvulsant in male gerbils.
    Journal of pineal research, 1996, Volume: 20, Issue:2

    Topics: Animals; Anticonvulsants; Circadian Rhythm; Dose-Response Relationship, Drug; Gerbillinae; Male; Mel

1996
Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice.
    Journal of pineal research, 1996, Volume: 21, Issue:2

    Topics: Animals; Brain; Cystine; Free Radical Scavengers; Injections, Intraventricular; Injections, Subcutan

1996
Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1996, Volume: 10, Issue:13

    Topics: Animals; Brain; Cerebrovascular Disorders; Kainic Acid; Male; Melatonin; Neuroprotective Agents; Pin

1996
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
    Journal of pineal research, 1998, Volume: 24, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid

1998
Pro-convulsant effects of oral melatonin in neurologically disabled children.
    Lancet (London, England), 1998, Apr-25, Volume: 351, Issue:9111

    Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Humans; Infant; Melatonin; Neuromuscular

1998
Oral melatonin in neurologically disabled children.
    Lancet (London, England), 1998, Jun-27, Volume: 351, Issue:9120

    Topics: Administration, Oral; Animals; Child; Humans; Melatonin; Nervous System Diseases; Rats; Seizures

1998
Oral melatonin in neurologically disabled children.
    Lancet (London, England), 1998, Jun-27, Volume: 351, Issue:9120

    Topics: Administration, Oral; Animals; Child; Humans; Melatonin; Nervous System Diseases; Seizures

1998
Anticonvulsant effects of melatonin in amygdala-kindled rats.
    Neuroscience letters, 1998, Nov-20, Volume: 257, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Circadian Rhythm; Disease Models, Animal; Dose-Response Relation

1998
Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:3

    Topics: Adenosine; Animals; Anticonvulsants; Avoidance Learning; Brain; Drug Interactions; Electroshock; Fem

1999
Melatonin attenuates the changes in polyamine levels induced by systemic kainate administration in rat brains.
    Journal of the neurological sciences, 2000, Sep-15, Volume: 178, Issue:2

    Topics: Animals; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Hippocampus; Kainic Acid; Mal

2000
Melatonin might be one possible medium of electroacupuncture anti-seizures.
    Acupuncture & electro-therapeutics research, 2001, Volume: 26, Issue:1-2

    Topics: Animals; Convulsants; Electroacupuncture; Electroencephalography; Electrophoresis, Capillary; Hippoc

2001
Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.
    Neurochemical research, 2001, Volume: 26, Issue:10

    Topics: Amantadine; Animals; Melatonin; Pentylenetetrazole; Piracetam; Rodentia; Seizures; Valproic Acid

2001
Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid.
    Toxicology letters, 2002, Mar-24, Volume: 129, Issue:1-2

    Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Free Radical Scavengers; Hydroxyl Radical; Kainic Ac

2002
Attenuating effects of melatonin on pilocarpine-induced seizures in rats.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2002, Volume: 131, Issue:4

    Topics: Age Factors; Animals; Anticonvulsants; Female; gamma-Aminobutyric Acid; Melatonin; N-Methylscopolami

2002
Effects of melatonin on the photosensitive epilepsy of the baboon, Papio papio.
    Electroencephalography and clinical neurophysiology, 1976, Volume: 41, Issue:3

    Topics: Animals; Disease Models, Animal; Electroencephalography; Evoked Potentials; Female; Haplorhini; Ligh

1976
Epileptogenic action of intraventricularly injected antimelatonin antibody.
    Neurology, 1977, Volume: 27, Issue:6

    Topics: Animals; Antibodies; Cerebral Ventricles; Electroencephalography; Injections; Male; Melatonin; Rats;

1977
Characterization of pinealectomy induced convulsions in the Mongolian gerbil (Meriones unguiculatus).
    Epilepsia, 1978, Volume: 19, Issue:5

    Topics: Age Factors; Animals; Circadian Rhythm; Ganglia, Autonomic; Gerbillinae; Light; Male; Melatonin; Par

1978
Influence of melatonin, constant light, or blinding on reproductive system of gerbils (Meriones unguiculatus).
    Experientia, 1976, Oct-15, Volume: 32, Issue:10

    Topics: Animals; Blindness; Body Weight; Female; Genitalia; Gerbillinae; Light; Litter Size; Male; Melatonin

1976
Novel anticonvulsant action of chronic melatonin in gerbils.
    Neuroreport, 1992, Volume: 3, Issue:12

    Topics: Animals; Anticonvulsants; Gerbillinae; Male; Melatonin; Organ Size; Pentylenetetrazole; Photoperiod;

1992
Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism.
    Chronobiology international, 1992, Volume: 9, Issue:2

    Topics: Animals; Behavior, Animal; Circadian Rhythm; Cricetinae; Flumazenil; Male; Melatonin; Mesocricetus;

1992
Time-dependent anticonvulsant activity of melatonin in hamsters.
    European journal of pharmacology, 1992, Jan-21, Volume: 210, Issue:3

    Topics: 3-Mercaptopropionic Acid; Animals; Circadian Rhythm; Cricetinae; Flumazenil; Injections, Intraperito

1992
Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels.
    Neuroendocrinology, 1989, Volume: 49, Issue:1

    Topics: Catecholamines; Circadian Rhythm; Epilepsy; Growth Hormone; Humans; Hydrocortisone; Melatonin; Pitui

1989
Increased geomagnetic activity and the occurrence of bereavement hallucinations: evidence for melatonin-mediated microseizuring in the temporal lobe?
    Neuroscience letters, 1988, Jun-07, Volume: 88, Issue:3

    Topics: Bereavement; Electromagnetic Fields; Electromagnetic Phenomena; Hallucinations; Humans; Melatonin; S

1988
Seizures in rats induced by pinealectomy: influence of diazepam, chlordiazepoxide, diphenylhydantoin and pineal substances.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 202, Issue:2

    Topics: Animals; Calcium; Chlordiazepoxide; Diazepam; Gluconates; Indoles; Male; Melatonin; Parathyroid Glan

1973
Ouabain-induced seizures in rats: modification by melatonin and melanocyte-stimulating hormone.
    Canadian journal of physiology and pharmacology, 1973, Volume: 51, Issue:8

    Topics: Animals; Brain; Cerebral Ventricles; Female; Heart Ventricles; Injections; Melanocyte-Stimulating Ho

1973