melatonin has been researched along with Seizures in 89 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Considering that the addition of melatonin to routine anti-seizure treatment was effective in reducing the severity of epilepsy and improving sleep quality, it seems that melatonin can be useful as an adjunct therapy for EGTCS in well-defined circumstances." | 9.69 | Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial. ( Alyan NajafAbadi, S; Maghbooli, M; MalekMahmoudi, G; Molseghi, MH, 2023) |
| "Plasma melatonin levels increased during seizures in the study group (P < 0." | 7.83 | Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures. ( Altun, D; Arslan, M; Dabak, O; Unay, B; Vurucu, S; Yaman, H; Yesilkaya, E, 2016) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 7.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| "We examined the effect of melatonin on brain levels of amino acids and nitric oxide (NO) after pentylenetetrazole (PTZ)-induced seizures in rats." | 7.72 | Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. ( Acuña-Castroviejo, D; Bikjdaouene, L; Escames, G; Ferrer, JM; Khaldy, H; León, J; Vives, F, 2003) |
| "The present study investigates the mechanisms involved in the anticonvulsant effect of melatonin in maximum electroshock (MES) seizures." | 7.72 | Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures. ( Mahajan, P; Mediratta, PK; Ray, M; Reeta, Kh; Sharma, KK, 2004) |
| "To explore the alteration of melatonin (MT) levels in pineal, hippocampus and serum during seizure crises and electroacupuncture (EA) anti-seizures, we established a rat seizure model by microinjecting benzylpenicillin into hippocampus." | 7.71 | Melatonin might be one possible medium of electroacupuncture anti-seizures. ( Chao, DM; Chen, G; Cheng, JS, 2001) |
| " However, the incidence of seizures induced by potassium cyanide was significantly inhibited by preadministration of melatonin (20 mg/kg, s." | 7.69 | Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. ( Tang, HW; Yamamoto, H, 1996) |
| "The effect of melatonin, a potent free radical scavenger, on L-cysteine-induced seizures and lipid peroxidation was investigated in mice." | 7.69 | Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice. ( Tang, H; Yamamoto, H, 1996) |
| " These results suggest that bereavement apparitions are situation-specific hallucinations evoked by microseizures within sensitized temporal lobe structures; the occurrence of these microseizures might be facilitated by suppression in melatonin levels that could accompany sudden increases in geomagnetic activity." | 7.67 | Increased geomagnetic activity and the occurrence of bereavement hallucinations: evidence for melatonin-mediated microseizuring in the temporal lobe? ( Persinger, MA, 1988) |
| "Clinical evaluation of seizure frequency, Chalfont-National Hospital seizure severity scale (NHS3), Pittsburgh sleep quality index (PSQI), quality of life in epilepsy inventory, Epworth sleepiness scale (ESS), and biochemical estimation of serum neuron-specific enolase (NSE) and glutathione reductase were done at baseline and compared with follow-up at 8 weeks." | 7.01 | Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial. ( Jena, M; Jha, M; Maiti, R; Mishra, A; Mishra, BR; Verma, N, 2021) |
| "Diurnal seizures decreased significantly with melatonin compared with placebo (P = ." | 6.77 | Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. ( Garty, BZ; Goldberg-Stern, H; Oren, H; Peled, N, 2012) |
| "There was also significant reduction in seizure severity." | 6.75 | Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010) |
| "In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy." | 6.47 | Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 5.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Considering that the addition of melatonin to routine anti-seizure treatment was effective in reducing the severity of epilepsy and improving sleep quality, it seems that melatonin can be useful as an adjunct therapy for EGTCS in well-defined circumstances." | 5.69 | Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial. ( Alyan NajafAbadi, S; Maghbooli, M; MalekMahmoudi, G; Molseghi, MH, 2023) |
| "Epilepsy is a chronic neurological disease with recurrent seizures." | 5.62 | Melatonin and Epilepsy. ( Vasileva, Z, 2021) |
| "Furthermore, the melatonin-pretreated seizure rats (Mel + RS) exhibited a significantly upregulated expression of calcium/calmodulin-dependent protein kinase II α (CaMKIIα), acetyl-Coenzyme A acetyltransferase 1 (ACAT1), ZnT-1, metallothionein 1 (MT-1), nSMase and Cathepsin-E, compared with the RS rats." | 5.42 | Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin. ( Feng, X; Ni, H; Sun, BL; Sun, Q; Tian, T, 2015) |
| "The seizures were induced by keeping the rats in 45 °C water and the experiments were performed in two steps." | 5.42 | Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures. ( Aydin, L; Gundogan, NU; Yazici, C, 2015) |
| "in patients with diurnal seizures (occurring mainly in the morning) may suggest proconvulsive effect of this hormone." | 5.40 | Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report. ( Czuczwar, SJ; Gołba, A; Motta, E; Norman, R; Ostrowska, Z; Sołtyk, J; Woźnik, G, 2014) |
| "Epilepsy is the most common neurological disorder, approximately 1% of the population worldwide have epilepsy." | 5.35 | Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis. ( Amado, D; Arida, RM; Cavalheiro, EA; Colugnati, DB; de Lima, E; Naffah-Mazzacoratti, Mda G; Scorza, FA, 2008) |
| "These seizures were completely abolished by the simultaneous administration of melatonin (20 mg/kg, ip), a potent scavenger of hydroxyl radical." | 5.31 | Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. ( Mohanan, PV; Yamamoto, HA, 2002) |
| "Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant." | 5.30 | Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998) |
| "The melatonin plasma levels were low for the chronological age but appropriate for the pubertal status, making a causal relationship between lowered melatonin plasma levels and precocious puberty possible." | 5.29 | Precocious puberty and decreased melatonin secretion due to a hypothalamic hamartoma. ( Commentz, JC; Helmke, K, 1995) |
| " Last, CPEB4-deficient mice showed altered circadian function, including altered melatonin blood levels and altered clustering of spontaneous seizures during the day." | 4.31 | CPEB4-CLOCK crosstalk during temporal lobe epilepsy. ( Alves, M; Auer, T; Beausang, A; Brennan, GP; Brett, FM; Carracedo-Rodríguez, G; Cryan, J; de Diego-Garcia, L; Delanty, N; Engel, T; Farrell, MA; Gil, B; Henshall, DC; Lau, K; Lucas, JJ; Martin-Gil, A; Mendez, R; Menendez-Mendez, A; Mitra, M; O'Brien, DF; Ollà, I; Parras, A; Villalba-Benito, L, 2023) |
| "Studies about the relationship between epileptic seizures (ESs) and melatonin are limited in children and have been performed in heterogeneous patient groups and with different methods." | 3.96 | The relationship between epileptic seizure and melatonin in children. ( Aksu Uzunhan, T; Kacar, A; Kucur, M; Saltik, S; Tarcin, G, 2020) |
| "Plasma melatonin levels increased during seizures in the study group (P < 0." | 3.83 | Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures. ( Altun, D; Arslan, M; Dabak, O; Unay, B; Vurucu, S; Yaman, H; Yesilkaya, E, 2016) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 3.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| "Phenobarbital is the most commonly utilized drug for neonatal seizures." | 3.79 | Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats. ( Duckles, A; Forcelli, PA; Gale, K; Kondratyev, A; Soper, C, 2013) |
| " This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.77 | The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011) |
| " This study investigated the effect of melatonin on biphasic modulation of seizure susceptibility by morphine, in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.74 | Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2007) |
| " In the present study, the involvement of NO pathway in the anticonvulsant effect of melatonin in pentylenetetrazole (PTZ)-induced clonic seizures was investigated in mice." | 3.73 | Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2006) |
| "We examined the effect of melatonin on brain levels of amino acids and nitric oxide (NO) after pentylenetetrazole (PTZ)-induced seizures in rats." | 3.72 | Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. ( Acuña-Castroviejo, D; Bikjdaouene, L; Escames, G; Ferrer, JM; Khaldy, H; León, J; Vives, F, 2003) |
| "The present study investigates the mechanisms involved in the anticonvulsant effect of melatonin in maximum electroshock (MES) seizures." | 3.72 | Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures. ( Mahajan, P; Mediratta, PK; Ray, M; Reeta, Kh; Sharma, KK, 2004) |
| "To explore the alteration of melatonin (MT) levels in pineal, hippocampus and serum during seizure crises and electroacupuncture (EA) anti-seizures, we established a rat seizure model by microinjecting benzylpenicillin into hippocampus." | 3.71 | Melatonin might be one possible medium of electroacupuncture anti-seizures. ( Chao, DM; Chen, G; Cheng, JS, 2001) |
| " The results support the hypothesis that suppression of the nocturnal concentrations of the endogenous anticonvulsant melatonin by sudden increases in geomagnetic activity may encourage fatal cardiac arrhythmias by uncoupling the insular/amygdaloid-paraventricular hypothalamic-solitary nucleus pathways." | 3.69 | Sudden unexpected death in epileptics following sudden, intense, increases in geomagnetic activity: prevalence of effect and potential mechanisms. ( Persinger, MA; Psych, C, 1995) |
| " However, the incidence of seizures induced by potassium cyanide was significantly inhibited by preadministration of melatonin (20 mg/kg, s." | 3.69 | Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. ( Tang, HW; Yamamoto, H, 1996) |
| "The effect of melatonin, a potent free radical scavenger, on L-cysteine-induced seizures and lipid peroxidation was investigated in mice." | 3.69 | Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice. ( Tang, H; Yamamoto, H, 1996) |
| " These results suggest that bereavement apparitions are situation-specific hallucinations evoked by microseizures within sensitized temporal lobe structures; the occurrence of these microseizures might be facilitated by suppression in melatonin levels that could accompany sudden increases in geomagnetic activity." | 3.67 | Increased geomagnetic activity and the occurrence of bereavement hallucinations: evidence for melatonin-mediated microseizuring in the temporal lobe? ( Persinger, MA, 1988) |
| "Clinical evaluation of seizure frequency, Chalfont-National Hospital seizure severity scale (NHS3), Pittsburgh sleep quality index (PSQI), quality of life in epilepsy inventory, Epworth sleepiness scale (ESS), and biochemical estimation of serum neuron-specific enolase (NSE) and glutathione reductase were done at baseline and compared with follow-up at 8 weeks." | 3.01 | Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial. ( Jena, M; Jha, M; Maiti, R; Mishra, A; Mishra, BR; Verma, N, 2021) |
| "Diurnal seizures decreased significantly with melatonin compared with placebo (P = ." | 2.77 | Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. ( Garty, BZ; Goldberg-Stern, H; Oren, H; Peled, N, 2012) |
| "There was also significant reduction in seizure severity." | 2.75 | Melatonin and sleep-related problems in children with intractable epilepsy. ( Abd-Elhamid, IA; Asaad, T; Elkhayat, HA; Elwakkad, AS; Hassanein, SM; Tomoum, HY, 2010) |
| "Epilepsy is a result of unprovoked, uncontrollable, and repetitive outburst of abnormal and excessive electrical discharges, known as seizures, in the neurons." | 2.72 | Melatonin as an Antiepileptic Molecule: Therapeutic Implications via Neuroprotective and Inflammatory Mechanisms. ( Akyuz, E; Arulsamy, A; Kullu, I; Shaikh, MF, 2021) |
| "Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect." | 2.48 | Melatonin utility in neonates and children. ( Chen, YC; Huang, LT; Sheen, JM; Tain, YL, 2012) |
| "In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy." | 2.47 | Melatonin in experimental seizures and epilepsy. ( Banach, M; Borowicz, KK; Gurdziel, E; Jędrych, M, 2011) |
| "Melatonin is a neurohormone naturally found in humans." | 2.44 | Neurobiological effects of melatonin as related to cancer. ( Hoang, BX; Levine, SA; Pham, PT; Shaw, DG, 2007) |
| "These include sleep disorders with a specific relationship to epilepsy, the influences of sleep and sleep deprivation on interictal epileptiform discharges, detrimental effects of seizures on sleep, and the effects (good and bad) of epilepsy treatments on sleep." | 2.42 | Sleep-related epilepsy. ( Bazil, CW, 2003) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 1.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "Epilepsy is a chronic neurological disease with recurrent seizures." | 1.62 | Melatonin and Epilepsy. ( Vasileva, Z, 2021) |
| "We found melatonin suppressed seizure-like behavior by using zebrafish regular locomotor assays." | 1.62 | Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. ( Gao, D; Jin, M; Li, N; Liu, K; Mou, L; Ren, Q; Sik, A; Zhang, M; Zhang, S, 2021) |
| "On the 15th day, the seizure was induced (except the control group) by intraperitoneal injection of PTZ." | 1.62 | Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress. ( Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Karimi, MY; Mehrzadi, S, 2021) |
| "The seizures were induced by keeping the rats in 45 °C water and the experiments were performed in two steps." | 1.42 | Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures. ( Aydin, L; Gundogan, NU; Yazici, C, 2015) |
| "Furthermore, the melatonin-pretreated seizure rats (Mel + RS) exhibited a significantly upregulated expression of calcium/calmodulin-dependent protein kinase II α (CaMKIIα), acetyl-Coenzyme A acetyltransferase 1 (ACAT1), ZnT-1, metallothionein 1 (MT-1), nSMase and Cathepsin-E, compared with the RS rats." | 1.42 | Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin. ( Feng, X; Ni, H; Sun, BL; Sun, Q; Tian, T, 2015) |
| "Anxiety and seizures are closely similar neurobehavioral disorders and are regulated by limbic system." | 1.40 | Differential neuromodulatory role of NO in anxiety and seizures: an experimental study. ( Gulati, K; Ray, A, 2014) |
| "in patients with diurnal seizures (occurring mainly in the morning) may suggest proconvulsive effect of this hormone." | 1.40 | Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report. ( Czuczwar, SJ; Gołba, A; Motta, E; Norman, R; Ostrowska, Z; Sołtyk, J; Woźnik, G, 2014) |
| "Melatonin has been mainly used for alleviating some disorders related with insomnia and circadian rhythmicity." | 1.39 | Behavioural actions of two new 1-N substituted analogues of melatonin. ( Bustamante-García, R; Lira-Rocha, AS; Naranjo-Rodríguez, EB; Ortiz-Osornio, A; Picazo, O, 2013) |
| "Oxidative stress usually accompanies seizures." | 1.38 | An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin. ( Deykun, K; Krýsl, D; Mareš, J; Pometlová, M; Rokyta, R, 2012) |
| "In the PTZ-induced seizure model, agomelatine (at 25 or 50mg/kg) showed a significant increase in latency to convulsion, and agomelatine (at 50 or 75 mg/kg) also increased significantly time until death." | 1.38 | Anticonvulsant effects of agomelatine in mice. ( Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Sousa, FC; do Vale, OC; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM; Viana, GS, 2012) |
| "Although melatonin influences seizure thresholds, the relationship is complex." | 1.37 | Light therapy as a treatment for epilepsy. ( Baxendale, SA, 2011) |
| " However, in both groups chronic administration of melatonin (20mg/kg) reversed the effect of LD cycle alteration on CST." | 1.35 | Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2008) |
| "Epilepsy is the most common neurological disorder, approximately 1% of the population worldwide have epilepsy." | 1.35 | Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis. ( Amado, D; Arida, RM; Cavalheiro, EA; Colugnati, DB; de Lima, E; Naffah-Mazzacoratti, Mda G; Scorza, FA, 2008) |
| " Theophylline, a re-emerging drug for the treatment of obstructive airway disease, has a narrow therapeutic index which precludes its safe use." | 1.34 | Free radicals and theophylline neurotoxicity : an experimental study. ( Gulati, K; Ray, A; Vijayan, VK, 2007) |
| "Aminophylline (50-250 mg/kg) induced convulsions and mortality in mice in a dose-dependent manner." | 1.33 | Possible role of free radicals in theophylline-induced seizures in mice. ( Gulati, K; Pal, G; Ray, A; Vijayan, VK, 2005) |
| "The damage of mtDNA and seizures induced by potassium cyanide were abolished by the pre-injection of melatonin (20 mg/kg)." | 1.31 | Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro. ( Mohanan, PV; Yamamoto, HA, 2002) |
| "These seizures were completely abolished by the simultaneous administration of melatonin (20 mg/kg, ip), a potent scavenger of hydroxyl radical." | 1.31 | Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. ( Mohanan, PV; Yamamoto, HA, 2002) |
| "Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant." | 1.30 | Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998) |
| "The melatonin plasma levels were low for the chronological age but appropriate for the pubertal status, making a causal relationship between lowered melatonin plasma levels and precocious puberty possible." | 1.29 | Precocious puberty and decreased melatonin secretion due to a hypothalamic hamartoma. ( Commentz, JC; Helmke, K, 1995) |
| "To assess whether electrically induced seizures are indeed required for the appearance of the blunted pineal response to isoproterenol, pineal and serum melatonin levels were measured after isoproterenol stimulation in rats treated with ECS (80 mA, 0." | 1.29 | Role of seizure activity in the decreased pineal response to isoproterenol in rats chronically treated with electroconvulsive shock. ( Amaro, S; d'Istria, M; De Luca, B; Maj, M; Monteleone, P; Serino, I, 1994) |
| "Locomotor activity, analgesia, and seizure susceptibility were maximal at the beginning of the scotophase and minimal at noon." | 1.28 | Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism. ( Burin, LJ; Cardinali, DP; De Brito Sánchez, MG; Escolar, E; Fernández Duque, D; Golombek, DA, 1992) |
| "Convulsions were induced by administering 3-mercaptopropionic acid (3-MP)." | 1.28 | Time-dependent anticonvulsant activity of melatonin in hamsters. ( Burin, L; Cardinali, DP; De Brito Sánchez, MG; Fernández Duque, D; Golombek, DA, 1992) |
| "During the seizure-free interval, the circadian profile of serum prolactin was lower in female patients than in healthy women." | 1.28 | Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels. ( Bauer, J; Rao, ML; Stefan, H, 1989) |
| "Melatonin-treated pinealectomized animals exhibited fewer seizures than did pinealectomized animals that did not receive melatonin." | 1.26 | Antiepileptic effects of melatonin in the pinealectomized Mongolian gerbil. ( Philo, RC; Rudeen, PK; Symmes, SK, 1980) |
| "In contrast neither the seizure threshold raising or sedative effect of melatonin (200 mg/kg) was reversed by Ro 15-1788." | 1.26 | Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663. ( Cowen, PJ; Green, AR; Nutt, DJ, 1982) |
| "Included in the convulsions are wild running, tonic-clonic activity, and occasionally death." | 1.26 | Characterization of pinealectomy induced convulsions in the Mongolian gerbil (Meriones unguiculatus). ( Philo, R; Reiter, RJ, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (14.61) | 18.7374 |
| 1990's | 21 (23.60) | 18.2507 |
| 2000's | 19 (21.35) | 29.6817 |
| 2010's | 24 (26.97) | 24.3611 |
| 2020's | 12 (13.48) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Ren, Q | 1 |
| Gao, D | 1 |
| Mou, L | 1 |
| Zhang, S | 1 |
| Zhang, M | 1 |
| Li, N | 1 |
| Sik, A | 1 |
| Jin, M | 1 |
| Liu, K | 1 |
| Hosseinzadeh, A | 2 |
| Dehdashtian, E | 2 |
| Jafari-Sabet, M | 1 |
| Mehrzadi, S | 2 |
| Vasileva, Z | 1 |
| Maghbooli, M | 1 |
| Alyan NajafAbadi, S | 1 |
| MalekMahmoudi, G | 1 |
| Molseghi, MH | 1 |
| de Diego-Garcia, L | 1 |
| Brennan, GP | 1 |
| Auer, T | 1 |
| Menendez-Mendez, A | 1 |
| Parras, A | 1 |
| Martin-Gil, A | 1 |
| Mitra, M | 1 |
| Ollà, I | 1 |
| Villalba-Benito, L | 1 |
| Gil, B | 1 |
| Alves, M | 1 |
| Lau, K | 1 |
| Delanty, N | 1 |
| Beausang, A | 1 |
| Cryan, J | 1 |
| Brett, FM | 1 |
| Farrell, MA | 1 |
| O'Brien, DF | 1 |
| Mendez, R | 1 |
| Carracedo-Rodríguez, G | 1 |
| Henshall, DC | 1 |
| Lucas, JJ | 1 |
| Engel, T | 1 |
| Campbell, S | 1 |
| Otten, H | 1 |
| Anand, V | 1 |
| Tchekalarova, J | 2 |
| Angelova, VT | 2 |
| Todorova, N | 2 |
| Andreeva-Gateva, P | 2 |
| Rangelov, M | 2 |
| Tarcin, G | 2 |
| Aksu Uzunhan, T | 1 |
| Kacar, A | 1 |
| Kucur, M | 1 |
| Saltik, S | 1 |
| Kennaway, DJ | 1 |
| Verma, N | 1 |
| Maiti, R | 1 |
| Mishra, BR | 1 |
| Jha, M | 1 |
| Jena, M | 1 |
| Mishra, A | 1 |
| Akyuz, E | 1 |
| Kullu, I | 1 |
| Arulsamy, A | 1 |
| Shaikh, MF | 1 |
| Hemati, K | 1 |
| Karimi, MY | 1 |
| Fatemi, I | 1 |
| Won, J | 1 |
| Jin, Y | 1 |
| Choi, J | 1 |
| Park, S | 1 |
| Lee, TH | 1 |
| Lee, SR | 2 |
| Chang, KT | 1 |
| Hong, Y | 1 |
| Dangalov, M | 1 |
| Kondeva-Burdina, M | 1 |
| Karabeliov, V | 1 |
| Shivachev, B | 1 |
| Forcelli, PA | 1 |
| Soper, C | 1 |
| Duckles, A | 1 |
| Gale, K | 1 |
| Kondratyev, A | 1 |
| Motta, E | 1 |
| Czuczwar, SJ | 2 |
| Ostrowska, Z | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin Supplementation on Sleep and Health of Children With Cerebral Palsy[NCT04392063] | 40 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| Melatonin for Neuroprotection Following Perinatal Asphyxia[NCT02071160] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for melatonin and Seizures
| Article | Year |
|---|---|
Melatonin as an Antiepileptic Molecule: Therapeutic Implications via Neuroprotective and Inflammatory Mechanisms.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Epilepsy; Humans; Melatonin; Seizures | 2021 |
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.
Topics: Anxiety; Autism Spectrum Disorder; Circadian Clocks; Circadian Rhythm; Fragile X Mental Retardation | 2017 |
Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin.
Topics: Anticonvulsants; Comorbidity; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interl | 2011 |
Melatonin in experimental seizures and epilepsy.
Topics: Animals; Anticonvulsants; Antioxidants; Child; Disease Models, Animal; Epilepsy; Humans; Melatonin; | 2011 |
Melatonin utility in neonates and children.
Topics: Antioxidants; Child; Female; Fetal Growth Retardation; Humans; Hypoxia-Ischemia, Brain; Infant, Newb | 2012 |
Sleep-related epilepsy.
Topics: Anticonvulsants; Electric Stimulation Therapy; Electroencephalography; Epilepsy; Humans; Melatonin; | 2003 |
Current trends in nitric oxide research.
Topics: Animals; Biomedical Research; Cell Adhesion Molecules; Cytokines; Estrogens; Gene Expression; Heat-S | 2007 |
Neurobiological effects of melatonin as related to cancer.
Topics: Aging; Antineoplastic Agents; Biological Clocks; Clinical Trials as Topic; Drug Evaluation, Preclini | 2007 |
Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence.
Topics: Animals; Anticonvulsants; Child Development; Circadian Rhythm; Free Radicals; Humans; Infant, Newbor | 1998 |
Neurobiology of pyridoxine.
Topics: Animals; Brain; Endocrine Glands; Hypothalamus; Melatonin; Nervous System; Pineal Gland; Pituitary G | 1990 |
The pineal gland: anatomy, physiology, and clinical significance.
Topics: Analgesia; Animals; Brain Neoplasms; Circadian Rhythm; Depression; Electroencephalography; Humans; H | 1985 |
Comparative physiology: pineal gland.
Topics: Aminobutyrates; Animals; Brain; Cricetinae; Electroencephalography; Electrophysiology; Female; Folli | 1973 |
5 trials available for melatonin and Seizures
| Article | Year |
|---|---|
Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Anticonvulsants; Cross-Sectional Studies; Epilepsy; Humans; Melatonin; Seizures; Sleep Qualit | 2023 |
Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial.
Topics: Adolescent; Adult; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Epilepsy, Genera | 2021 |
Melatonin and sleep-related problems in children with intractable epilepsy.
Topics: Adolescent; Bruxism; Child; Child, Preschool; Epilepsy; Female; Humans; Hypnotics and Sedatives; Mal | 2010 |
Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study.
Topics: Actigraphy; Adolescent; Adult; Antioxidants; Child; Cross-Over Studies; Epilepsy; Female; Humans; Ma | 2012 |
Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment.
Topics: Anticonvulsants; Antioxidants; Child; Cross-Over Studies; Double-Blind Method; Female; Humans; Melat | 1998 |
72 other studies available for melatonin and Seizures
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy; Gene | 2021 |
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice.
Topics: Animals; Anticonvulsants; Cholecalciferol; Disease Models, Animal; Epilepsy; Melatonin; Mice; Pentyl | 2022 |
Melatonin and Epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Epilepsy; Humans; Melatonin; Seizures | 2021 |
CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
Topics: Animals; CLOCK Proteins; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Male | 2023 |
CYP450 Genetic Polymorphisms: Generalized Tonic-Clonic Seizure after Intentional Fluoxetine and Melatonin Overdose.
Topics: Cytochrome P-450 Enzyme System; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fluo | 2023 |
Evaluation of the anticonvulsant effect of novel melatonin derivatives in the intravenous pentylenetetrazol seizure test in mice.
Topics: Administration, Intravenous; Animals; Anticonvulsants; Drug Interactions; Male; Melatonin; Mice; Mol | 2019 |
The relationship between epileptic seizure and melatonin in children.
Topics: Child; Electroencephalography; Epilepsy; Humans; Melatonin; Seizures; Status Epilepticus | 2020 |
Response to Dr. Kennaway.
Topics: Child; Epilepsy; Humans; Melatonin; Seizures | 2021 |
Melatonin measurement in epilepsy; are the assays letting us down?
Topics: Child; Epilepsy; Humans; Melatonin; Seizures | 2021 |
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Melatonin; Mice; Oxidative Stress; Pentylene | 2021 |
Discovery of novel indole-based aroylhydrazones as anticonvulsants: Pharmacophore-based design.
Topics: Animals; Anticonvulsants; Drug Design; Drug Discovery; Hepatocytes; Hydrazones; Male; Melatonin; Mic | 2019 |
Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Drug T | 2013 |
Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report.
Topics: Adult; Circadian Rhythm; Epilepsy; Female; Humans; Male; Melatonin; Middle Aged; Saliva; Seizures; Y | 2014 |
Differential neuromodulatory role of NO in anxiety and seizures: an experimental study.
Topics: Aminophylline; Animals; Anxiety; Arginine; Enzyme Inhibitors; Male; Malondialdehyde; Melatonin; Neur | 2014 |
Prophylactic treatment with melatonin before recurrent neonatal seizures: Effects on long-term neurobehavioral changes and the underlying expression of metabolism-related genes in rat hippocampus and cerebral cortex.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Animals, Newborn; Behavior, Animal; Calcium-Calmodulin-Depe | 2015 |
Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Topics: Animals; Animals, Newborn; Central Nervous System Depressants; Gene Expression Regulation; Hippocamp | 2015 |
Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats.
Topics: Animals; Antioxidants; Biological Availability; Brain; Central Nervous System Depressants; Disease M | 2015 |
Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Administration Schedule; Hy | 2015 |
Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cir | 2016 |
Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2016 |
Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice.
Topics: Animals; Circadian Rhythm; Disease Susceptibility; Male; Melatonin; Mice; Pentylenetetrazole; Photop | 2008 |
Light therapy as a treatment for epilepsy.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Humans; Light; Melatonin; Models, Biological; Mo | 2011 |
Multiple sclerosis and seizures: possible role of Helicobacter pylori.
Topics: Anticonvulsants; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-18; Melatonin; Multiple S | 2011 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela | 2011 |
An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin.
Topics: Analysis of Variance; Animals; Antioxidants; Automatism; Blood-Brain Barrier; Convulsants; Disease M | 2012 |
Anticonvulsant effects of agomelatine in mice.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Female; Melaton | 2012 |
Behavioural actions of two new 1-N substituted analogues of melatonin.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antioxidants; Anxiety; Behavior, Animal; Diazepam; Do | 2013 |
Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro.
Topics: Animals; Brain Chemistry; DNA Damage; DNA, Mitochondrial; Electrophoresis, Agar Gel; Free Radical Sc | 2002 |
Adenosine receptors do not mediate the melatonin protection against pentylenetetrazole induced seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Male; Melatonin; Pentylenetetrazole; Purinergic P1 Receptor Ant | 2001 |
Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Male; Melatonin; Nitric Oxide; Pentylenet | 2003 |
Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures.
Topics: Animals; Anticonvulsants; Electroshock; GABA-A Receptor Agonists; Male; Melatonin; Mice; Receptors, | 2004 |
Possible role of free radicals in theophylline-induced seizures in mice.
Topics: Aminophylline; Animals; Bronchodilator Agents; Female; Free Radicals; Male; Melatonin; Mice; NG-Nitr | 2005 |
Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Drug Therapy, Com | 2006 |
Free radicals and theophylline neurotoxicity : an experimental study.
Topics: alpha-Tocopherol; Aminophylline; Animals; Antioxidants; Arginine; Ascorbic Acid; Dose-Response Relat | 2007 |
Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway.
Topics: Animals; Anticonvulsants; Antioxidants; Convulsants; Dose-Response Relationship, Drug; Electric Stim | 2007 |
Cardiovascular protective effect of melatonin in sudden unexpected death in epilepsy: a hypothesis.
Topics: Cardiotonic Agents; Death, Sudden; Epilepsy; Humans; Melatonin; Models, Biological; Risk Factors; Se | 2008 |
Melatonin increases following convulsive seizures may be related to its anticonvulsant properties at physiological concentrations.
Topics: Adolescent; Analysis of Variance; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; | 2007 |
Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.
Topics: Animals; Arousal; Benzodiazepinones; Brain; Diazepam; Dose-Response Relationship, Drug; Exploratory | 1982 |
The anticonvulsant properties of melatonin on kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Melatonin; Naloxone; Penty | 1981 |
Antiepileptic effects of melatonin in the pinealectomized Mongolian gerbil.
Topics: Animals; Drug Implants; Gerbillinae; Male; Melatonin; Pineal Gland; Seizures | 1980 |
Sudden unexpected death in epileptics following sudden, intense, increases in geomagnetic activity: prevalence of effect and potential mechanisms.
Topics: Animals; Arrhythmias, Cardiac; Death, Sudden; Electromagnetic Phenomena; Epilepsy; Geography; Humans | 1995 |
Role of seizure activity in the decreased pineal response to isoproterenol in rats chronically treated with electroconvulsive shock.
Topics: Animals; Electroshock; Isoproterenol; Male; Melatonin; Norepinephrine; Pineal Gland; Rats; Rats, Spr | 1994 |
Average diurnal changes in melatonin levels are associated with hourly incidence of bereavement apparitions: support for the hypothesis of temporal (limbic) lobe microseizuring.
Topics: Adrenocorticotropic Hormone; Bereavement; Circadian Rhythm; Death; Female; Humans; Male; Melatonin; | 1993 |
Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice.
Topics: Animals; Antidotes; Brain; Dose-Response Relationship, Drug; Injections, Subcutaneous; Lethal Dose 5 | 1996 |
Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice.
Topics: Animals; Cyanides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Lipid Peroxidation; Male; | 1996 |
Precocious puberty and decreased melatonin secretion due to a hypothalamic hamartoma.
Topics: Female; Gonadotropin-Releasing Hormone; Hamartoma; Humans; Hypothalamic Neoplasms; Infant; Magnetic | 1995 |
Acute and chronic effects of melatonin as an anticonvulsant in male gerbils.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Dose-Response Relationship, Drug; Gerbillinae; Male; Mel | 1996 |
Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice.
Topics: Animals; Brain; Cystine; Free Radical Scavengers; Injections, Intraventricular; Injections, Subcutan | 1996 |
Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.
Topics: Animals; Brain; Cerebrovascular Disorders; Kainic Acid; Male; Melatonin; Neuroprotective Agents; Pin | 1996 |
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid | 1998 |
Pro-convulsant effects of oral melatonin in neurologically disabled children.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Humans; Infant; Melatonin; Neuromuscular | 1998 |
Oral melatonin in neurologically disabled children.
Topics: Administration, Oral; Animals; Child; Humans; Melatonin; Nervous System Diseases; Rats; Seizures | 1998 |
Oral melatonin in neurologically disabled children.
Topics: Administration, Oral; Animals; Child; Humans; Melatonin; Nervous System Diseases; Seizures | 1998 |
Anticonvulsant effects of melatonin in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Circadian Rhythm; Disease Models, Animal; Dose-Response Relation | 1998 |
Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice.
Topics: Adenosine; Animals; Anticonvulsants; Avoidance Learning; Brain; Drug Interactions; Electroshock; Fem | 1999 |
Melatonin attenuates the changes in polyamine levels induced by systemic kainate administration in rat brains.
Topics: Animals; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Hippocampus; Kainic Acid; Mal | 2000 |
Melatonin might be one possible medium of electroacupuncture anti-seizures.
Topics: Animals; Convulsants; Electroacupuncture; Electroencephalography; Electrophoresis, Capillary; Hippoc | 2001 |
Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.
Topics: Amantadine; Animals; Melatonin; Pentylenetetrazole; Piracetam; Rodentia; Seizures; Valproic Acid | 2001 |
Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid.
Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Free Radical Scavengers; Hydroxyl Radical; Kainic Ac | 2002 |
Attenuating effects of melatonin on pilocarpine-induced seizures in rats.
Topics: Age Factors; Animals; Anticonvulsants; Female; gamma-Aminobutyric Acid; Melatonin; N-Methylscopolami | 2002 |
Effects of melatonin on the photosensitive epilepsy of the baboon, Papio papio.
Topics: Animals; Disease Models, Animal; Electroencephalography; Evoked Potentials; Female; Haplorhini; Ligh | 1976 |
Epileptogenic action of intraventricularly injected antimelatonin antibody.
Topics: Animals; Antibodies; Cerebral Ventricles; Electroencephalography; Injections; Male; Melatonin; Rats; | 1977 |
Characterization of pinealectomy induced convulsions in the Mongolian gerbil (Meriones unguiculatus).
Topics: Age Factors; Animals; Circadian Rhythm; Ganglia, Autonomic; Gerbillinae; Light; Male; Melatonin; Par | 1978 |
Influence of melatonin, constant light, or blinding on reproductive system of gerbils (Meriones unguiculatus).
Topics: Animals; Blindness; Body Weight; Female; Genitalia; Gerbillinae; Light; Litter Size; Male; Melatonin | 1976 |
Novel anticonvulsant action of chronic melatonin in gerbils.
Topics: Animals; Anticonvulsants; Gerbillinae; Male; Melatonin; Organ Size; Pentylenetetrazole; Photoperiod; | 1992 |
Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism.
Topics: Animals; Behavior, Animal; Circadian Rhythm; Cricetinae; Flumazenil; Male; Melatonin; Mesocricetus; | 1992 |
Time-dependent anticonvulsant activity of melatonin in hamsters.
Topics: 3-Mercaptopropionic Acid; Animals; Circadian Rhythm; Cricetinae; Flumazenil; Injections, Intraperito | 1992 |
Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels.
Topics: Catecholamines; Circadian Rhythm; Epilepsy; Growth Hormone; Humans; Hydrocortisone; Melatonin; Pitui | 1989 |
Increased geomagnetic activity and the occurrence of bereavement hallucinations: evidence for melatonin-mediated microseizuring in the temporal lobe?
Topics: Bereavement; Electromagnetic Fields; Electromagnetic Phenomena; Hallucinations; Humans; Melatonin; S | 1988 |
Seizures in rats induced by pinealectomy: influence of diazepam, chlordiazepoxide, diphenylhydantoin and pineal substances.
Topics: Animals; Calcium; Chlordiazepoxide; Diazepam; Gluconates; Indoles; Male; Melatonin; Parathyroid Glan | 1973 |
Ouabain-induced seizures in rats: modification by melatonin and melanocyte-stimulating hormone.
Topics: Animals; Brain; Cerebral Ventricles; Female; Heart Ventricles; Injections; Melanocyte-Stimulating Ho | 1973 |