melatonin has been researched along with Seasonal Affective Disorder in 104 studies
Seasonal Affective Disorder: A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The ingestion of L-tryptophan during the day is hypothesized to increase the levels of melatonin, released from the gastrointestinal tract, in patients with winter seasonal affective disorder (SAD)." | 7.70 | Extrapineal melatonin and exogenous serotonin in seasonal affective disorder. ( Partonen, T, 1998) |
| "The aim was to investigate the secretion profile of melatonin and seasonal affective disorder before and after treatment with fluoxetine." | 7.69 | Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls. ( Allen, NH; Childs, PA; Martin, NJ; Plaskett, L; Rodin, I; Smythe, PJ; Thompson, C, 1995) |
| "To investigate the role of a light-induced advance in the timing of the melatonin rhythm in seasonal affective disorder, 11 depressed patients underwent 2 weeks of light therapy with full spectrum or cool white light." | 7.69 | Effect of light therapy on salivary melatonin in seasonal affective disorder. ( Bielski, RJ; Mayor, J; Rice, J; Tucker, HA, 1995) |
| "Night-time melatonin secretion was measured in five depressed inpatients with seasonal affective disorder before and after 1-week of morning and evening exposure to bright (3000 lux) and dim (300 lux) light." | 7.68 | Hypersecretion of melatonin following diurnal exposure to bright light in seasonal affective disorder: preliminary results. ( Dardennes, RM; Hakim-Kreis, CM; Musa, CZ; Piketty, ML; Salinas, EO, 1992) |
| "We examined 24-hour melatonin rhythms from 20 patients with seasonal affective disorder (SAD) and 20 healthy volunteers." | 7.68 | Melatonin rhythms in seasonal affective disorder. ( Abbas, M; Arendt, J; Checkley, SA; Franey, C; Marks, M; Murphy, DG; Murphy, DM; Palazidou, E; Winton, F, 1993) |
| "Melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala." | 5.42 | Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. ( Furuse, M; Goda, R; Iwamoto, A; Kawai, M; Matsuo, H; Nagasawa, M; Nagy, AD; Otsuka, T; Yasuo, S, 2015) |
| "The following test of the circadian phase-shift hypothesis for patients with winter depression (seasonal affective disorder, or SAD) uses low-dose melatonin administration in the morning or afternoon/evening to induce phase delays or phase advances, respectively, without causing sleepiness." | 5.12 | The circadian basis of winter depression. ( Bauer, VK; Emens, JS; Lefler, BJ; Lewy, AJ, 2006) |
| "We tested the hypothesis that phase-delayed circadian rhythms underlie seasonal affective disorder (SAD) by measuring phase position of 6-sulfatoxymelatonin excretion and comparing antidepressant response to morning or evening light given as a first treatment." | 5.07 | Light therapy in seasonal affective disorder is independent of time of day or circadian phase. ( Arendt, J; Buddeberg, C; Fisch, HU; Gisin, B; Graw, P; Jochum, A; Kräuchi, K; Pöldinger, W; Wirz-Justice, A, 1993) |
| "Bright light treatment is the most potent melatonin suppressor and circadian phase shifter and is a safe nonpharmacologic antidepressant for seasonal depression." | 4.82 | Circadian phase shifting, alerting, and antidepressant effects of bright light treatment. ( Oren, DA; Postolache, TT, 2005) |
| "The onset of melatonin secretion under dim light conditions (DLMO) and the circadian temperature rhythm during a constant routine were assessed in 6 female controls and 6 female patients with winter depression (seasonal affective disorder, SAD) before and after bright light treatment." | 4.78 | Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression. ( Avery, DH; Brengelmann, GL; Dahl, K; Larsen, LH; Lewy, AJ; Prinz, PN; Savage, MV; Vitiello, MV, 1993) |
| " The following communication is concerned with the association among MS, pregnancy, the postpartum period, and melatonin secretion and illustrates, based on a clinical case report, the influence of the pineal gland on the clinical course of MS." | 4.78 | The pineal gland and the clinical course of multiple sclerosis. ( Sandyk, R, 1992) |
| "Plasma melatonin was sampled in 42 patients with seasonal affective disorder, in the evening or overnight while depressed and after 10 to 14 days of light therapy (10 000 lux for 30 minutes) when symptoms were reassessed." | 3.71 | Circadian time of morning light administration and therapeutic response in winter depression. ( Cooper, TB; Lo, ES; Terman, JS; Terman, M, 2001) |
| "The pathogenesis of seasonal affective disorder (SAD) has been attributed to abnormal melatonin metabolism." | 3.70 | Psoralens in association with seasonal affective disorder. ( Partonen, T, 1998) |
| "Eighteen patients with seasonal affective disorder and 18 controls first completed a 24-hour study in which their melatonin profiles were characterized." | 3.70 | Serotonin 1A receptors, melatonin, and the proportional control thermostat in patients with winter depression. ( Rosenthal, NE; Schwartz, PJ; Wehr, TA, 1998) |
| " The ingestion of L-tryptophan during the day is hypothesized to increase the levels of melatonin, released from the gastrointestinal tract, in patients with winter seasonal affective disorder (SAD)." | 3.70 | Extrapineal melatonin and exogenous serotonin in seasonal affective disorder. ( Partonen, T, 1998) |
| "To investigate the role of a light-induced advance in the timing of the melatonin rhythm in seasonal affective disorder, 11 depressed patients underwent 2 weeks of light therapy with full spectrum or cool white light." | 3.69 | Effect of light therapy on salivary melatonin in seasonal affective disorder. ( Bielski, RJ; Mayor, J; Rice, J; Tucker, HA, 1995) |
| "The aim was to investigate the secretion profile of melatonin and seasonal affective disorder before and after treatment with fluoxetine." | 3.69 | Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls. ( Allen, NH; Childs, PA; Martin, NJ; Plaskett, L; Rodin, I; Smythe, PJ; Thompson, C, 1995) |
| "We examined 24-hour melatonin rhythms from 20 patients with seasonal affective disorder (SAD) and 20 healthy volunteers." | 3.68 | Melatonin rhythms in seasonal affective disorder. ( Abbas, M; Arendt, J; Checkley, SA; Franey, C; Marks, M; Murphy, DG; Murphy, DM; Palazidou, E; Winton, F, 1993) |
| "Night-time melatonin secretion was measured in five depressed inpatients with seasonal affective disorder before and after 1-week of morning and evening exposure to bright (3000 lux) and dim (300 lux) light." | 3.68 | Hypersecretion of melatonin following diurnal exposure to bright light in seasonal affective disorder: preliminary results. ( Dardennes, RM; Hakim-Kreis, CM; Musa, CZ; Piketty, ML; Salinas, EO, 1992) |
| "Patients with winter depression (seasonal affective disorder (SAD)) commonly complain of sleepiness." | 2.71 | Melatonin treatment of winter depression following total sleep deprivation: waking EEG and mood correlates. ( Danilenko, KV; Putilov, AA, 2005) |
| "Five patients with winter depression received low doses of melatonin in the afternoon, and five patients received placebo capsules." | 2.69 | Melatonin treatment of winter depression: a pilot study. ( Bauer, VK; Cutler, NL; Lewy, AJ; Sack, RL, 1998) |
| "to 33 patients with winter depression." | 2.67 | Early-morning administration of short-acting beta blockers for treatment of winter depression. ( Schlager, DS, 1994) |
| "True winter depression (SAD) appears to be rare, although subsyndromal SAD is reported." | 2.48 | Biological rhythms during residence in polar regions. ( Arendt, J, 2012) |
| "The consequences of chronic sleep deprivation on energy expenditure have not been fully explored." | 2.47 | Chronic sleep deprivation and seasonality: implications for the obesity epidemic. ( Cizza, G; de Jonge, L; Galli, G; Requena, M, 2011) |
| "Bright light therapy is used to treat seasonal affective disorders." | 2.46 | Circadian rhythms and depression. ( Barriball, E; Boyce, P, 2010) |
| "Melatonin has been shown to be involved in the regulation of both cellular and humoral immunity." | 2.44 | Immunomodulation by melatonin: its significance for seasonally occurring diseases. ( Cardinali, DP; Maestroni, GJ; Pandi-Perumal, SR; Spence, DW; Srinivasan, V; Trakht, I, 2008) |
| "The leading hypothesis for winter depression (seasonal affective disorder, or SAD) is the phase shift hypothesis (PSH)." | 2.44 | The phase shift hypothesis for the circadian component of winter depression. ( Emens, JS; Lewy, AJ; Mishra, N; Rough, JN; Songer, JB; Yuhas, K, 2007) |
| "Low melatonin levels were seen in bulimia or neuralgia and in women with fibromyalgia; replacement reduced pain, sleeping disorders, and depression in fibromyalgia and bulimia." | 2.41 | Melatonin deficiencies in women. ( Herold, J; Rohr, UD, 2002) |
| "Melatonin has few immediate side-effects except drowsiness, but the effects of chronic administration are unclear." | 2.40 | Guidelines for prescribing melatonin. ( Avery, D; Landis, C; Lenz, M, 1998) |
| "Melatonin has received much ill-formed publicity, it being claimed that it is a panacea and an 'antiageing' treatment." | 2.40 | Disorders of the sleep-wake cycle in adults. ( Sedgwick, PM, 1998) |
| "Melatonin seems to be an indicator of disturbed circadian rhythm rather than the cause of SAD." | 2.39 | [Seasonal affective disorders]. ( Christensen, EM; Gjerris, A, 1995) |
| "The severe form of winter depression affects about 5% of the general population and is believed to be caused by light deficiency." | 2.38 | Magnetic fields and seasonality of affective illness: implications for therapy. ( Anninos, PA; Sandyk, R; Tsagas, N, 1991) |
| "Seasonal affective disorder is defined as recurrent episodes of major depression, mania, or hypomania with seasonal onset and remission." | 1.46 | Secondary to excessive melatonin synthesis, the consumption of tryptophan from outside the blood-brain barrier and melatonin over-signaling in the pars tuberalis may be central to the pathophysiology of winter depression. ( Alves, RC; Pereira, JC; Pradella Hallinan, M, 2017) |
| "Melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala." | 1.42 | Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. ( Furuse, M; Goda, R; Iwamoto, A; Kawai, M; Matsuo, H; Nagasawa, M; Nagy, AD; Otsuka, T; Yasuo, S, 2015) |
| "Melatonin was assayed by an ELISA technique." | 1.33 | Seasonality of psychopathology and circannual melatonin rhythm. ( Abreu, P; Morera, AL, 2006) |
| "The etiology of winter depression (seasonal affective disorder, or SAD) is not known, but a number of studies have provided support for both photoperiod and neurotransmitter hypotheses." | 1.32 | Does neuroimmune dysfunction mediate seasonal mood changes in winter depression? ( Lam, RW; Song, C; Yatham, LN, 2004) |
| "The melatonin amplitude was significantly decreased by light, and the melatonin phase position was advanced by morning light and delayed by evening light." | 1.29 | Melatonin in light treatment of patients with seasonal and nonseasonal depression. ( Kjellman, BF; Mørkrid, L; Thalén, BE; Wetterberg, L, 1995) |
| "Melatonin was measured in the serum and urine before and after 1 hr of bright light (350 cd/m2)." | 1.29 | Obesity treated with phototherapy: four case studies. ( Boman, K; Bylesjö, EI; Wetterberg, L, 1996) |
| "Most patients with winter depression are suggested to have a phase delay in their circadian rhythms." | 1.29 | Involvement of melatonin and serotonin in winter depression. ( Partonen, T, 1994) |
| "Sleep, appetite and weight increase in winter depression and decrease in summer depression." | 1.28 | Seasonal vulnerability to depression. Implications for etiology and treatment. ( Wehr, TA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 48 (46.15) | 18.2507 |
| 2000's | 39 (37.50) | 29.6817 |
| 2010's | 17 (16.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Forneris, CA | 3 |
| Nussbaumer-Streit, B | 2 |
| Morgan, LC | 3 |
| Greenblatt, A | 3 |
| Van Noord, MG | 3 |
| Gaynes, BN | 3 |
| Wipplinger, J | 3 |
| Lux, LJ | 3 |
| Winkler, D | 4 |
| Gartlehner, G | 3 |
| Kaminski-Hartenthaler, A | 2 |
| Ikeno, T | 1 |
| Weil, ZM | 1 |
| Nelson, RJ | 2 |
| Gardner, C | 1 |
| Nagy, AD | 1 |
| Iwamoto, A | 1 |
| Kawai, M | 1 |
| Goda, R | 1 |
| Matsuo, H | 1 |
| Otsuka, T | 1 |
| Nagasawa, M | 1 |
| Furuse, M | 1 |
| Yasuo, S | 1 |
| Nussbaumer, B | 1 |
| Sonis, JH | 1 |
| Hofmann, J | 1 |
| Xu, LZ | 1 |
| Liu, LJ | 1 |
| Yuan, M | 1 |
| Li, SX | 1 |
| Yue, XD | 1 |
| Lai, JL | 1 |
| Lu, L | 1 |
| Pereira, JC | 1 |
| Pradella Hallinan, M | 1 |
| Alves, RC | 1 |
| Pääkkönen, T | 1 |
| Leppäluoto, J | 1 |
| Mäkinen, TM | 1 |
| Rintamäki, H | 1 |
| Ruokonen, A | 1 |
| Hassi, J | 1 |
| Palinkas, LA | 1 |
| Srinivasan, V | 2 |
| Spence, DW | 1 |
| Trakht, I | 1 |
| Pandi-Perumal, SR | 2 |
| Cardinali, DP | 2 |
| Maestroni, GJ | 1 |
| Lavoie, MP | 1 |
| Lam, RW | 3 |
| Bouchard, G | 2 |
| Sasseville, A | 2 |
| Charron, MC | 1 |
| Gagné, AM | 2 |
| Tremblay, P | 2 |
| Filteau, MJ | 1 |
| Hébert, M | 2 |
| Radeljak, S | 1 |
| Zarković-Palijan, T | 1 |
| Kovacević, D | 1 |
| Kovac, M | 1 |
| Azorin, JM | 1 |
| Kaladjian, A | 1 |
| Nieuwenhuis, RF | 1 |
| Spooren, PF | 1 |
| Tilanus, JJ | 1 |
| Boyce, P | 1 |
| Barriball, E | 1 |
| Terman, M | 5 |
| Workman, JL | 1 |
| Molnar, E | 1 |
| Gonda, X | 1 |
| Rihmer, Z | 1 |
| Bagdy, G | 1 |
| Cizza, G | 1 |
| Requena, M | 1 |
| Galli, G | 1 |
| de Jonge, L | 1 |
| Pail, G | 1 |
| Huf, W | 1 |
| Pjrek, E | 1 |
| Willeit, M | 1 |
| Praschak-Rieder, N | 1 |
| Kasper, S | 1 |
| Kim, DR | 1 |
| Czarkowski, KA | 1 |
| Epperson, CN | 1 |
| Arendt, J | 5 |
| Koorengevel, KM | 3 |
| Beersma, DG | 3 |
| den Boer, JA | 3 |
| van den Hoofdakker, RH | 3 |
| Magnusson, A | 1 |
| Boivin, D | 1 |
| Leppämäki, S | 2 |
| Partonen, T | 6 |
| Vakkuri, O | 2 |
| Lönnqvist, J | 3 |
| Partinen, M | 1 |
| Laudon, M | 1 |
| Nakajima, T | 1 |
| Song, C | 1 |
| Yatham, LN | 1 |
| Danilenko, KV | 4 |
| Putilov, AA | 4 |
| Miller, AL | 1 |
| Postolache, TT | 2 |
| Oren, DA | 2 |
| Nyström, M | 1 |
| Saarijärvi, S | 1 |
| Räihä, H | 1 |
| Johnsson, A | 1 |
| Moan, J | 1 |
| Lewy, AJ | 9 |
| Lefler, BJ | 1 |
| Emens, JS | 2 |
| Bauer, VK | 3 |
| Emens, J | 1 |
| Jackman, A | 1 |
| Yuhas, K | 2 |
| Smits, M | 1 |
| Spence, W | 1 |
| Lowe, AD | 1 |
| Kayumov, L | 1 |
| Parry, B | 1 |
| Morera, AL | 1 |
| Abreu, P | 1 |
| Bordet, R | 1 |
| Bhattacharjee, Y | 1 |
| Rough, JN | 1 |
| Songer, JB | 1 |
| Mishra, N | 1 |
| Wehr, TA | 4 |
| Schwartz, PJ | 3 |
| Turner, EH | 2 |
| Feldman-Naim, S | 1 |
| Drake, CL | 1 |
| Rosenthal, NE | 3 |
| Rice, J | 1 |
| Mayor, J | 1 |
| Tucker, HA | 1 |
| Bielski, RJ | 1 |
| Dijk, DJ | 1 |
| Boulos, Z | 1 |
| Eastman, CI | 1 |
| Campbell, SS | 1 |
| Christensen, EM | 1 |
| Gjerris, A | 1 |
| Childs, PA | 3 |
| Rodin, I | 2 |
| Martin, NJ | 2 |
| Allen, NH | 2 |
| Plaskett, L | 1 |
| Smythe, PJ | 2 |
| Thompson, C | 3 |
| Healy, D | 1 |
| Waterhouse, JM | 1 |
| Raheja, SK | 1 |
| Russkikh, GS | 2 |
| Duffy, LK | 1 |
| Ebbesson, SO | 1 |
| Schlager, DS | 1 |
| Kay, RW | 1 |
| Wirz-Justice, A | 2 |
| Graw, P | 2 |
| Kräuchi, K | 2 |
| Gisin, B | 1 |
| Jochum, A | 1 |
| Fisch, HU | 1 |
| Buddeberg, C | 1 |
| Pöldinger, W | 1 |
| Dahl, K | 1 |
| Avery, DH | 1 |
| Savage, MV | 1 |
| Brengelmann, GL | 1 |
| Larsen, LH | 1 |
| Vitiello, MV | 1 |
| Prinz, PN | 1 |
| Heleniak, EP | 1 |
| Murphy, DG | 2 |
| Murphy, DM | 2 |
| Abbas, M | 2 |
| Palazidou, E | 2 |
| Binnie, C | 1 |
| Campos Costa, D | 1 |
| Checkley, SA | 2 |
| Marks, M | 1 |
| Winton, F | 1 |
| Franey, C | 1 |
| Sarrafzadeh, A | 1 |
| English, J | 1 |
| Sand, L | 1 |
| Thalén, BE | 2 |
| Kjellman, BF | 2 |
| Mørkrid, L | 2 |
| Wetterberg, L | 4 |
| Bylesjö, EI | 1 |
| Boman, K | 1 |
| Lee, TM | 1 |
| Blashko, CA | 1 |
| Janzen, HL | 1 |
| Paterson, JG | 1 |
| Chan, CC | 1 |
| Avery, D | 1 |
| Lenz, M | 1 |
| Landis, C | 1 |
| Sedgwick, PM | 1 |
| Cutler, NL | 2 |
| Sack, RL | 2 |
| Ahmed, S | 1 |
| Thomas, KH | 1 |
| Blood, ML | 1 |
| Jackson, JM | 1 |
| Nathan, PJ | 1 |
| Burrows, GD | 1 |
| Norman, TR | 1 |
| Sher, L | 3 |
| Levitan, RD | 1 |
| Terman, JS | 1 |
| Lo, ES | 1 |
| Cooper, TB | 1 |
| Weir, E | 1 |
| McColl, SL | 1 |
| Veitch, JA | 1 |
| Gordijn, MC | 1 |
| Meesters, Y | 1 |
| Daan, S | 1 |
| Duncan, WC | 1 |
| Aeschbach, D | 1 |
| Káradóttir, R | 1 |
| Axelsson, J | 1 |
| Laitinen, JT | 1 |
| Porkka-Heiskanen, T | 1 |
| Rohr, UD | 1 |
| Herold, J | 1 |
| Sandyk, R | 3 |
| Dann, LC | 1 |
| Anninos, PA | 1 |
| Tsagas, N | 1 |
| Cherepanova, VA | 1 |
| Hawkins, L | 1 |
| Ford, K | 1 |
| Salinas, EO | 1 |
| Hakim-Kreis, CM | 1 |
| Piketty, ML | 1 |
| Dardennes, RM | 1 |
| Musa, CZ | 1 |
| Yamashita, T | 1 |
| Azekawa, T | 1 |
| Yoshida, M | 1 |
| Maietta, G | 1 |
| Rongioletti, F | 1 |
| Rebora, A | 1 |
| Mishima, K | 1 |
| Okawa, M | 1 |
| Hishikawa, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Controlled Trial of Bright Light Therapy on All-Cause Excessive Daytime Sleepiness in Prader-Willi Syndrome[NCT05939453] | 30 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | |||
| Randomized Placebo-Controlled Trial of Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder[NCT00502320] | Phase 4 | 50 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression: Double-Blind, Placebo-Controlled Study to Establish Efficacy and Safety[NCT00590265] | 50 participants (Anticipated) | Interventional | 2008-01-31 | Active, not recruiting | |||
| Melatonin Studies of Blind Children[NCT00691444] | 10 participants (Actual) | Interventional | 2002-09-30 | Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.) | |||
| Light and Ion Therapy for Seasonal Affective Disorder[NCT00006517] | 150 participants (Actual) | Interventional | 1998-09-30 | Completed | |||
| Optimizing Light Wavelength for Treatment of Seasonal Affective Disorder[NCT00269633] | Phase 2 | 9 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Melatonin Entrainment of Elderly Blind Free-runners[NCT00692094] | 12 participants (Actual) | Interventional | 2004-08-31 | Terminated (stopped due to Unique provision in the American Recovery and Reinvestment Act prevented approval of second year no-cost-extension in which completion of analyses were planned.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinician-rated measure of mood; evaluates classical 21 Hamilton Depression items, and 8-item subscale measuring atypical depression symptoms which commonly occur during SAD episodes. Score ranges from 0-89, higher scores indicate higher levels of depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)
| Intervention | scores on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Month 1 | Month 2 | Month 3 | Month 4 | |
| Placebo | 19.99 | 15.97 | 19.47 | 20.65 | 23.68 |
| Ramelteon | 22.68 | 16.16 | 14.81 | 11.69 | 9.15 |
Self-rated scale to measure severity of depressive symptoms. Score ranges from 25-100, higher scores reflect more depression. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)
| Intervention | scores on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Month 1 | Month 2 | Month 3 | Month 4 | |
| Placebo | 58.63 | 56.40 | 58.59 | 58.62 | 61.65 |
| Ramelteon | 63.06 | 54.35 | 53.51 | 49.26 | 46.14 |
Self-rated scale to measure quality of sleep via questions regarding sleep latency, duration, efficiency, disturbances, use of sleep medication, and daytime dysfunction. Score ranges from 0-21, higher scores represent more significant sleep disturbance. (NCT00502320)
Timeframe: Monthly for duration of treatment (up to 4 months)
| Intervention | scores on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Month 1 | Month 2 | Month 3 | Month 4 | |
| Placebo | 11.45 | 8.67 | 8.62 | 9.88 | 9.61 |
| Ramelteon | 11.56 | 9.52 | 7.57 | 8.07 | 7.05 |
Outcome for Structured Interview Guide for the Hamilton Depression Scale - Seasonal Affective Disorder Version (SIGH-SAD) reported is the average over 3 weeks. Lower values represent less depressive symptoms. Range is 0-53. (NCT00269633)
Timeframe: Averaged over Three Weeks During Treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Red Light Box 657 nm | 16.3 |
| Blue Light Box 467 nm | 8 |
42 reviews available for melatonin and Seasonal Affective Disorder
| Article | Year |
|---|---|
Psychological therapies for preventing seasonal affective disorder.
Topics: Antidepressive Agents; Cognitive Behavioral Therapy; Depressive Disorder, Major; Humans; Melatonin; | 2019 |
Melatonin and agomelatine for preventing seasonal affective disorder.
Topics: Acetamides; Adult; Antidepressive Agents; Humans; Melatonin; Placebos; Seasonal Affective Disorder | 2019 |
Melatonin and agomelatine for preventing seasonal affective disorder.
Topics: Acetamides; Adult; Humans; Melatonin; Seasonal Affective Disorder | 2015 |
Immunomodulation by melatonin: its significance for seasonally occurring diseases.
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Humans; Immunity, Cellular; Immunologic Factors; Lymphoid | 2008 |
Chromotherapy in the regulation of neurohormonal balance in human brain--complementary application in modern psychiatric treatment.
Topics: Color Therapy; Depressive Disorder; Humans; Melatonin; Seasonal Affective Disorder; Serotonin; Sleep | 2008 |
[Depression and circadian rhythm].
Topics: Biological Clocks; Circadian Rhythm; Depressive Disorder; Humans; Melatonin; Seasonal Affective Diso | 2009 |
[When a season means depression].
Topics: Affect; Brain Chemistry; Catecholamines; Circadian Rhythm; Disorders of Excessive Somnolence; Foreca | 2010 |
Circadian rhythms and depression.
Topics: Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Family Practice; Female; Humans; Incid | 2010 |
[Etiopathology and therapy of seasonal affective disorder].
Topics: Acetamides; Antidepressive Agents; Circadian Rhythm; Cognitive Behavioral Therapy; Humans; Hypnotics | 2010 |
Chronic sleep deprivation and seasonality: implications for the obesity epidemic.
Topics: Adipose Tissue, Brown; Adult; Aged; Animals; Energy Intake; Energy Metabolism; Female; Hibernation; | 2011 |
Bright-light therapy in the treatment of mood disorders.
Topics: Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Mood Disorders; Phototherapy; Seasonal | 2011 |
The relationship between bipolar disorder, seasonality, and premenstrual symptoms.
Topics: Bipolar Disorder; Depression, Postpartum; Female; Humans; Melatonin; Premenstrual Syndrome; Seasonal | 2011 |
Biological rhythms during residence in polar regions.
Topics: Acclimatization; Activities of Daily Living; Affect; Antarctic Regions; Arctic Regions; Biological C | 2012 |
Seasonal affective disorder: an overview.
Topics: Chronobiology Phenomena; Circadian Rhythm; Humans; Melatonin; Models, Biological; Photoperiod; Photo | 2003 |
[Phototherapy(in neuropsychiatry)].
Topics: Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Serotonin | 2003 |
Epidemiology, etiology, and natural treatment of seasonal affective disorder.
Topics: Humans; Hypericum; Melatonin; Phototherapy; Phytotherapy; Seasonal Affective Disorder; Serotonin | 2005 |
Circadian phase shifting, alerting, and antidepressant effects of bright light treatment.
Topics: Adaptation, Physiological; Adult; Bipolar Disorder; Circadian Rhythm; Depression; Eye Diseases; Fema | 2005 |
[Light and mood therapy].
Topics: Female; Finland; Humans; Male; Melatonin; Mood Disorders; Phototherapy; Prognosis; Risk Factors; Sea | 2005 |
[Winter seasonal affective disorder (SAD) ].
Topics: Antidepressive Agents; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Finland; Hum | 2006 |
[Rhythms, depressions and light].
Topics: Animals; Biological Clocks; Bipolar Disorder; Brain; Circadian Rhythm; Humans; Jet Lag Syndrome; Lig | 2006 |
Circadian uses of melatonin in humans.
Topics: Blindness; Circadian Rhythm; Humans; Melatonin; Periodicity; Seasonal Affective Disorder; Seasons; S | 2006 |
Melatonin in mood disorders.
Topics: Antidepressive Agents; Biomarkers; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Depressi | 2006 |
[The melatonin system, biological rhythms and mood disorders].
Topics: Affect; Circadian Rhythm; Depressive Disorder; Homeostasis; Humans; Hypothalamus; Melatonin; Pineal | 2006 |
The phase shift hypothesis for the circadian component of winter depression.
Topics: Circadian Rhythm; Humans; Melatonin; Models, Biological; Phototherapy; Seasonal Affective Disorder | 2007 |
Melatonin and human chronobiology.
Topics: Blindness; Chronobiology Phenomena; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Huma | 2007 |
Light treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances.
Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Sleep Stages; Sleep | 1995 |
[Seasonal affective disorders].
Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder | 1995 |
The circadian system and the therapeutics of the affective disorders.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Behavior Therapy; Bipolar Disorder; Circadian | 1995 |
Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression.
Topics: Adult; Body Temperature; Circadian Rhythm; Female; Humans; Light; Melatonin; Phototherapy; Seasonal | 1993 |
Pathophysiological mechanism of seasonal affective disorder.
Topics: Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Treatment Outcome | 1997 |
Guidelines for prescribing melatonin.
Topics: Aged; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Drug Administration Schedule; Female; | 1998 |
Disorders of the sleep-wake cycle in adults.
Topics: Adult; Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Sleep Initiat | 1998 |
Seasonal affective disorder.
Topics: Brain; Female; Humans; Male; Melatonin; Phototherapy; Seasonal Affective Disorder; Serotonin | 1998 |
Melatonin as a marker and phase-resetter of circadian rhythms in humans.
Topics: Biomarkers; Circadian Rhythm; Darkness; Humans; Light; Melatonin; Photoperiod; Phototherapy; Seasona | 1999 |
Pathophysiology of seasonal affective disorder: a review.
Topics: Circadian Rhythm; Humans; Melatonin; Neurotransmitter Agents; Seasonal Affective Disorder | 2000 |
Full-spectrum fluorescent lighting: a review of its effects on physiology and health.
Topics: Arousal; Biological Evolution; Brain; Calcium; Female; Fluorescence; Health Status; Humans; Hydrocor | 2001 |
[Physiology of the biological clock and the relation of circadian rhythm disorders to illnesses].
Topics: Animals; Biological Clocks; Blindness; Chronobiology Disorders; Humans; Jet Lag Syndrome; Light; Mel | 1999 |
Melatonin deficiencies in women.
Topics: Breast Neoplasms; Circadian Rhythm; Depression; Female; Humans; Jet Lag Syndrome; Melatonin; Menopau | 2002 |
The pineal gland and the clinical course of multiple sclerosis.
Topics: Calcinosis; Female; Humans; Melatonin; Middle Aged; Multiple Sclerosis; Pineal Gland; Postpartum Per | 1992 |
Magnetic fields and seasonality of affective illness: implications for therapy.
Topics: Circadian Rhythm; Electromagnetic Fields; Humans; Melatonin; Phototherapy; Pineal Gland; Seasonal Af | 1991 |
Seasonal affective disorders: the effects of light on human behaviour.
Topics: Body Temperature; Circadian Rhythm; Humans; Hydrocortisone; Light; Melatonin; Seasonal Affective Dis | 1992 |
Light therapy of depression; basal and clinical aspects.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Sleep Depri | 1992 |
13 trials available for melatonin and Seasonal Affective Disorder
| Article | Year |
|---|---|
Evidence of a biological effect of light therapy on the retina of patients with seasonal affective disorder.
Topics: Adult; Analysis of Variance; Case-Control Studies; Electroretinography; Female; Humans; Male; Melato | 2009 |
Circadian rhythm phase advance with dawn simulation treatment for winter depression.
Topics: Air Ionization; Circadian Rhythm; Humans; Melatonin; Phototherapy; Rod Opsins; Seasonal Affective Di | 2010 |
Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour.
Topics: Adult; Affect; Circadian Rhythm; Delayed-Action Preparations; Double-Blind Method; Female; Humans; M | 2003 |
Melatonin treatment of winter depression following total sleep deprivation: waking EEG and mood correlates.
Topics: Adolescent; Adult; Affect; Case-Control Studies; Disorders of Excessive Somnolence; Double-Blind Met | 2005 |
The circadian basis of winter depression.
Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Seasonal Affectiv | 2006 |
The circadian basis of winter depression.
Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Seasonal Affectiv | 2006 |
The circadian basis of winter depression.
Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Seasonal Affectiv | 2006 |
The circadian basis of winter depression.
Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Seasonal Affectiv | 2006 |
Early-morning administration of short-acting beta blockers for treatment of winter depression.
Topics: Adolescent; Adult; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Female; Huma | 1994 |
Light therapy in seasonal affective disorder is independent of time of day or circadian phase.
Topics: Age Factors; Ambulatory Care; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Person | 1993 |
'Natural' light treatment of seasonal affective disorder.
Topics: Adult; Circadian Rhythm; Double-Blind Method; Female; Humans; Hydrocortisone; Male; Melatonin; Middl | 1996 |
Suppression of melatonin secretion by bright light in seasonal affective disorder.
Topics: Adult; Female; Humans; Male; Melatonin; Middle Aged; Phototherapy; Psychiatric Status Rating Scales; | 1997 |
Effects of morning phototherapy on circadian markers in seasonal affective disorder.
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Phototherapy; Seasonal Affective Disorder; | 1997 |
Morning vs evening light treatment of patients with winter depression.
Topics: Adult; Circadian Rhythm; Cross-Over Studies; Female; Humans; Male; Melatonin; Middle Aged; Photoperi | 1998 |
Melatonin treatment of winter depression: a pilot study.
Topics: Adult; Arousal; Circadian Rhythm; Depressive Disorder, Major; Dose-Response Relationship, Drug; Doub | 1998 |
Extraocular light therapy in winter depression: a double-blind placebo-controlled study.
Topics: Adult; Body Temperature; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Melatonin; Pho | 2001 |
49 other studies available for melatonin and Seasonal Affective Disorder
| Article | Year |
|---|---|
Photoperiod affects the diurnal rhythm of hippocampal neuronal morphology of Siberian hamsters.
Topics: Animals; ARNTL Transcription Factors; Brain; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Cr | 2013 |
Creating the right light for older people.
Topics: Aged; Circadian Rhythm; Dementia; Equipment Design; Humans; Lighting; Melatonin; Phototherapy; Seaso | 2014 |
Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Circadian Clocks; Circadian Rhythm; Disease Models | 2015 |
Short photoperiod condition increases susceptibility to stress in adolescent male rats.
Topics: Aging; Anhedonia; Animals; Circadian Rhythm; Corticosterone; Disease Models, Animal; Disease Suscept | 2016 |
Secondary to excessive melatonin synthesis, the consumption of tryptophan from outside the blood-brain barrier and melatonin over-signaling in the pars tuberalis may be central to the pathophysiology of winter depression.
Topics: Animals; Blood-Brain Barrier; Central Nervous System; Depressive Disorder, Major; Diet; Humans; Ligh | 2017 |
Seasonal levels of melatonin, thyroid hormones, mood, and cognition near the Arctic Circle.
Topics: Adult; Affect; Arctic Regions; Cognition; Cold Climate; Finland; Humans; Male; Melatonin; Photoperio | 2008 |
[Less need for insulin, a surprising effect of phototherapy in insulin-dependent diabetes mellitus].
Topics: Adult; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Humans; Hypoglyce | 2009 |
Potential animal models of seasonal affective disorder.
Topics: Animals; Brain; Cricetinae; Disease Models, Animal; Humans; Melatonin; Rats; Seasonal Affective Diso | 2011 |
A forced desynchrony study of circadian pacemaker characteristics in seasonal affective disorder.
Topics: Adult; Body Temperature; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Polysomnogr | 2002 |
Mood regulation in seasonal affective disorder patients and healthy controls studied in forced desynchrony.
Topics: Adult; Affect; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male; Me | 2003 |
Highlights and abstracts of the fifteenth annual Society for Light Treatment and Biological Rhythms virtual meeting 2003.
Topics: Biological Clocks; Circadian Rhythm; Clinical Trials as Topic; Depression; Humans; Melatonin; Photot | 2003 |
Does neuroimmune dysfunction mediate seasonal mood changes in winter depression?
Topics: Animals; Humans; Melatonin; Models, Biological; Neurogenic Inflammation; Neuroimmunomodulation; Phot | 2004 |
Seasonality of psychopathology and circannual melatonin rhythm.
Topics: Adult; Humans; Melatonin; Psychopathology; Seasonal Affective Disorder; Seasons | 2006 |
Patient information. Seasonal affective disorder.
Topics: Humans; Melatonin; Nurse Practitioners; Phototherapy; Risk Factors; Seasonal Affective Disorder; Sel | 2006 |
Psychiatric research. Is internal timing key to mental health?
Topics: Animals; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Clinical Trials as Topic; Hum | 2007 |
Bimodal patterns of human melatonin secretion consistent with a two-oscillator model of regulation.
Topics: Adult; Circadian Rhythm; Female; Humans; Melatonin; Middle Aged; Models, Biological; Seasonal Affect | 1995 |
Effect of light therapy on salivary melatonin in seasonal affective disorder.
Topics: Adult; Analysis of Variance; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Phototh | 1995 |
Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls.
Topics: Adult; Female; Fluoxetine; Humans; Hypothalamus; Male; Melatonin; Receptors, Adrenergic, beta-1; Sea | 1995 |
Involvement of melatonin and serotonin in winter depression.
Topics: Animals; Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder; Serotonin | 1994 |
Seasonal affective disorder.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Circadian Rhythm; Diagnosis, Differential; Female; Huma | 1994 |
Diurnal and seasonal variations of melatonin and serotonin in women with seasonal affective disorder.
Topics: Adult; Analysis of Variance; Case-Control Studies; Circadian Rhythm; Dietary Carbohydrates; Feeding | 1994 |
Geomagnetic storms: association with incidence of depression as measured by hospital admission.
Topics: Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Geological Phenomena; Geology; Hosp | 1994 |
Seasonal affective disorder: lower or raised resting metabolic rate?
Topics: Basal Metabolism; Cold Temperature; Humans; Light; Melatonin; Models, Biological; Seasonal Affective | 1993 |
Seasonal affective disorder: response to light as measured by electroencephalogram, melatonin suppression, and cerebral blood flow.
Topics: Bipolar Disorder; Brain; Cerebral Cortex; Circadian Rhythm; Contrast Sensitivity; Depressive Disorde | 1993 |
Melatonin rhythms in seasonal affective disorder.
Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Individuality; Male; | 1993 |
Melatonin in light treatment of patients with seasonal and nonseasonal depression.
Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Ph | 1995 |
Obesity treated with phototherapy: four case studies.
Topics: Dietary Carbohydrates; Female; Food Preferences; Humans; Melatonin; Middle Aged; Obesity; Photothera | 1996 |
Cortisol in light treatment of seasonal and non-seasonal depression: relationship between melatonin and cortisol.
Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Male | 1997 |
Tweaking the human circadian clock with light.
Topics: Bilirubin; Circadian Rhythm; Hemoglobins; Humans; Knee; Light; Light Signal Transduction; Melatonin; | 1998 |
Psoralens in association with seasonal affective disorder.
Topics: 5-Methoxypsoralen; Furocoumarins; Humans; Light; Liver; Melatonin; Methoxsalen; Models, Neurological | 1998 |
Serotonin 1A receptors, melatonin, and the proportional control thermostat in patients with winter depression.
Topics: Adult; Body Temperature Regulation; Circadian Rhythm; Female; Humans; Male; Melatonin; Pyrimidines; | 1998 |
Extrapineal melatonin and exogenous serotonin in seasonal affective disorder.
Topics: Animals; Cells, Cultured; Digestive System; Humans; Leukocytes, Mononuclear; Light; Melatonin; Pinea | 1998 |
Melatonin sensitivity to dim white light in affective disorders.
Topics: Adolescent; Adult; Aged; Biomarkers; Bipolar Disorder; Depressive Disorder, Major; Humans; Light; Me | 1999 |
Melatonin, psoralens, and the genetic basis of seasonal affective disorder and seasonality.
Topics: Female; Furocoumarins; Genetic Predisposition to Disease; Humans; Male; Melatonin; Seasonal Affectiv | 2000 |
Phase of melatonin rhythm in winter depression.
Topics: Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Russia; Seasonal Affective Disorder; | 1999 |
Circadian time of morning light administration and therapeutic response in winter depression.
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Phototherapy; Seasonal Affect | 2001 |
Winter needn't be the SAD season.
Topics: Canada; Circadian Rhythm; Humans; Melatonin; Phototherapy; Seasonal Affective Disorder | 2001 |
A circadian signal of change of season in patients with seasonal affective disorder.
Topics: Adult; Circadian Rhythm; Female; Humans; Hypothalamus; Male; Melatonin; Middle Aged; Nerve Net; Refe | 2001 |
Internal night.
Topics: Adult; Circadian Rhythm; Darkness; Female; Humans; Hypothalamus; Male; Melatonin; Middle Aged; Nerve | 2001 |
Melatonin secretion in SAD patients and healthy subjects matched with respect to age and sex.
Topics: Adult; Age Factors; Aged; Circadian Rhythm; Female; Humans; Iceland; Male; Melatonin; Middle Aged; R | 2001 |
Genetics of seasonal affective disorder.
Topics: Female; Humans; Male; Melatonin; Seasonal Affective Disorder; Seasons | 2002 |
Seasonal panic disorder: a possible variant of seasonal affective disorder.
Topics: Adult; Alprazolam; Anxiety Disorders; Circadian Rhythm; Combined Modality Therapy; Depressive Disord | 1992 |
Seasonal vulnerability to depression. Implications for etiology and treatment.
Topics: Corticotropin-Releasing Hormone; Depressive Disorder; Female; Humans; Light; Male; Melanocyte-Stimul | 1992 |
The effects of phototherapy (PT) on diurnal rhythms of physiological parameters and melatonin excretion in subjects with seasonal affective disorder (SAD).
Topics: Body Temperature; Circadian Rhythm; Heart Rate; Humans; Melatonin; Phototherapy; Respiration; Season | 1991 |
A seasonal depression. Management of seasonal affective disorder.
Topics: Humans; Melatonin; Phototherapy; Seasonal Affective Disorder | 1992 |
Hypersecretion of melatonin following diurnal exposure to bright light in seasonal affective disorder: preliminary results.
Topics: Adult; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Photoperiod; Phototherapy; | 1992 |
A case of reversed seasonal affective disorder.
Topics: Adult; Humans; Light; Male; Melatonin; Seasonal Affective Disorder; Seasons; Sensory Deprivation | 1992 |
Seborrheic dermatitis and daylight.
Topics: Dermatitis, Seborrheic; Humans; Melatonin; Seasonal Affective Disorder; Seasons; Sunlight | 1991 |
Circadian rhythm of melatonin secretion and body temperature in a patient with seasonal affective disorder.
Topics: Aged; Bipolar Disorder; Body Temperature Regulation; Circadian Rhythm; Female; Humans; Melatonin; Ps | 1991 |