melatonin has been researched along with Scoliosis in 67 studies
Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although there are many alterations of melatonin in subjects with adolescent idiopathic scoliosis, the many variables present do not allow to establish a direct cause-effect relationship." | 9.22 | Melatonin and adolescent idiopathic scoliosis: The present evidence. ( Gargano, G; Maffulli, N; Migliorini, F; Oliva, F, 2022) |
| "The application of the melatonin antagonist of Luzindole can improve the success rate of the bipedal rat scoliosis model." | 7.85 | The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model. ( Jiang, J; Jin, X; Lu, F; Ma, X; Xia, X; Yang, S; Zheng, C; Zhu, W, 2017) |
| "The melatonin deficiency hypothesis as a central mechanism in the pathogenesis of adolescent idiopathic scoliosis (AIS) is certainly intriguing." | 7.80 | Higher levels of melatonin in early stages of adolescent idiopathic scoliosis: toward a new scenario. ( Goultidis, TT; Kapetanos, GA; Papavasiliou, KA; Petropoulos, AS; Philippopoulos, A, 2014) |
| "Abnormalities in the melatonin signaling pathway and the involvement of melatonin receptor MT2 have been reported in patients with adolescent idiopathic scoliosis (AIS)." | 7.80 | Abnormal response of the proliferation and differentiation of growth plate chondrocytes to melatonin in adolescent idiopathic scoliosis. ( Cheng, JC; Lee, KM; Man, GC; Ng, BK; Ng, TB; Qiu, Y; Wang, WW; Wong, JH; Yeung, HY, 2014) |
| "Genetic association study investigating the association of genetic markers of melatonin signaling and biosynthesis with adolescent idiopathic scoliosis (AIS)." | 7.77 | Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis. ( Nelson, LM; Ogilvie, JW; Ward, K, 2011) |
| "Melatonin deficiency has been postulated as an etiologic factors in adolescent idiopathic scoliosis (AIS)." | 7.76 | Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin. ( Cheng, JC; Hung, WY; Lee, SK; Man, GC; Ng, BK; Ng, TB; Qiu, Y; Wang, WW; Wong, JH; Yeung, BH, 2010) |
| "To investigate the melatonin signaling transduction pathway in BMSCs from adolescent idiopathic scoliosis patients." | 7.76 | [A preliminary study of melatonin signaling transduction pathway in BMSCs from adolescent idiopathic scoliosis patients]. ( Li, HB; Qiu, XS; Qiu, Y; Sun, GQ; Wang, B; Wang, WJ; Zhu, F, 2010) |
| "The correlation of serum melatonin levels and curve progression in adolescent idiopathic scoliosis, and the effects of melatonin therapy in scoliotic patients with reduced levels of endogenous melatonin were studied in 40 adolescent patients with moderate to severe idiopathic scoliosis." | 7.75 | Serum melatonin levels in adolescent idiopathic scoliosis prediction and prevention for curve progression--a prospective study. ( Dubousset, J; Kimura, J; Machida, M; Yamada, T, 2009) |
| "Melatonin and calmodulin are potential key molecules in scoliosis etiology." | 7.75 | Comparison of the melatonin and calmodulin in paravertebral muscle and platelets of patients with or without adolescent idiopathic scoliosis. ( Acaroglu, E; Akel, I; Alanay, A; Marcucio, R; Yazici, M, 2009) |
| "The 2[125I]iodomelatonin binding assay was used to investigate the involvement of melatonin receptors in the development of scoliosis in pinealectomized chickens." | 7.73 | Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens. ( Cheung, KM; Leong, JC; Lu, DS; Poon, AM, 2006) |
| "In addition to the induction of scoliosis in chickens by pinealectomy (PINX), we previously demonstrated that removal of the pineal gland also produces scoliosis in bipedal rats, which can be inhibited by melatonin treatment." | 7.73 | Bipedal ambulation induces experimental scoliosis in C57BL/6J mice with reduced plasma and pineal melatonin levels. ( Kanazawa, K; Machida, M; Murai, I; Oyama, J, 2006) |
| "To determine whether suppression of melatonin secretion without surgery in chickens can result in scoliosis development." | 7.72 | Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy. ( Cheung, KM; Leong, JC; Lu, DS; Luk, KD; Poon, AM; Wang, T, 2003) |
| "To determine whether a dysfunction of the melatonin-signaling pathway in tissues targeted by this hormone is involved in adolescent idiopathic scoliosis." | 7.72 | Melatonin signaling dysfunction in adolescent idiopathic scoliosis. ( Angeloni, D; Azeddine, B; Forget, S; Fraschini, F; Grimard, G; Labelle, H; Moreau, A; Poitras, B; Rivard, CH; Wang, DS, 2004) |
| "We might hypothesize that the high rate of pseudarthrosis after spinal fusion for neurofibromatous scoliosis is related to two factors: the absence of neurofibromin and melatonin deficiency." | 7.71 | The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis. ( Abdel-Wanis, ME; Kawahara, N, 2002) |
| "To assess serum melatonin levels in adolescents with idiopathic scoliosis." | 7.70 | Adolescent idiopathic scoliosis. Is low melatonin a cause? ( al-Habdan, I; al-Othman, A; Sadat-Ali, M, 2000) |
| "In adolescent idiopathic scoliosis, neither the presentation with a stable spinal deformity, nor presentation with a severe deformity requiring surgery is associated with melatonin deficiency." | 7.70 | Total 24-hour melatonin secretion in adolescent idiopathic scoliosis. A case-control study. ( Fagan, AB; Kennaway, DJ; Sutherland, AD, 1998) |
| " Radiographs and blood samples were taken at weekly intervals to monitor scoliosis development and measure serum melatonin levels using radioimmunoassay techniques." | 7.70 | Changes in serum melatonin levels in response to pinealectomy in the chicken and its correlation with development of scoliosis. ( Bagnall, K; Jiang, H; Mahood, J; Moreau, M; Raso, VJ; Wang, X; Zhao, J, 1998) |
| "We studied the possible role of melatonin deficiency in experimentally-induced scoliosis." | 7.69 | Role of melatonin deficiency in the development of scoliosis in pinealectomised chickens. ( Dubousset, J; Imamura, Y; Iwaya, T; Kimura, J; Machida, M; Yamada, T, 1995) |
| "Experimentally induced scoliosis in chicken by pinealectomy can be attributed to the defect in melatonin metabolism." | 7.69 | Melatonin. A possible role in pathogenesis of adolescent idiopathic scoliosis. ( Dubousset, J; Imamura, Y; Kimura, J; Machida, M; Miyashita, Y; Yamada, T, 1996) |
| "Whereas pinealectomy in young chickens leads to reduced melatonin levels and the development of scoliosis, the results of this study suggest that melatonin levels in mature patients who already have severe scoliosis do not differ from healthy subjects." | 7.69 | Melatonin levels in idiopathic scoliosis. Diurnal and nocturnal serum melatonin levels in girls with adolescent idiopathic scoliosis. ( Bagnall, KM; Bering, M; Buzzell, GR; Hill, DL; Jiang, H; Mahood, JK; Moreau, M; Raso, VJ; Russell, G, 1996) |
| "To determine whether melatonin production is decreased in adolescent idiopathic scoliosis." | 7.69 | The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis. ( Blakemore, LC; Farley, FA; Greenfield, ML; Hariharan, M; Hensinger, RN; Hilibrand, AS; Loder, RT, 1996) |
| "None of mice with melatonin treatment developed scoliosis." | 5.33 | Experimental scoliosis in melatonin-deficient C57BL/6J mice without pinealectomy. ( Dubousset, J; Kimura, J; Machida, M; Saito, M; Shiraishi, T; Yamada, T; Yamagishi, M, 2006) |
| "The postoperative kyphosis and scoliosis angles were 30 degrees and 12 degrees, respectively." | 5.31 | The association of neurofibromatosis 1 and spinal deformity with primary hyperparathyroidism and osteomalacia: might melatonin have a role? ( Abdel-Wanis, ME; Kawahara, N; Tomita, K, 2001) |
| "Scoliosis was assessed on weekly radiographs, and the Cobb angle was determined for all chickens in which scoliosis developed." | 5.30 | The effects of melatonin therapy on the development of scoliosis after pinealectomy in the chicken. ( Bagnall, K; Mahood, J; Moreau, M; Raso, VJ; Wang, X; Zhao, J, 1999) |
| "It is well-documented that melatonin deficiency has been linked to the etiopathogenesis of adolescent idiopathic scoliosis." | 3.91 | The effect of exogenous melatonin on reducing scoliotic curvature and improving bone quality in melatonin-deficient C57BL/6J mice. ( Bao, H; Cheng, JCY; Chun, TC; Guo, J; Han, X; Hu, Z; Jiang, Q; Lam, TP; Li, J; Liu, H; Liu, Z; Man, CW; Ng, TB; Qiao, J; Qiu, Y; Shi, B; Wang, W; Xu, L; Zhao, Z; Zhu, Z, 2019) |
| "The application of the melatonin antagonist of Luzindole can improve the success rate of the bipedal rat scoliosis model." | 3.85 | The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model. ( Jiang, J; Jin, X; Lu, F; Ma, X; Xia, X; Yang, S; Zheng, C; Zhu, W, 2017) |
| "The melatonin deficiency hypothesis as a central mechanism in the pathogenesis of adolescent idiopathic scoliosis (AIS) is certainly intriguing." | 3.80 | Higher levels of melatonin in early stages of adolescent idiopathic scoliosis: toward a new scenario. ( Goultidis, TT; Kapetanos, GA; Papavasiliou, KA; Petropoulos, AS; Philippopoulos, A, 2014) |
| "Genetic association study investigating the association of genetic markers of melatonin signaling and biosynthesis with adolescent idiopathic scoliosis (AIS)." | 3.77 | Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis. ( Nelson, LM; Ogilvie, JW; Ward, K, 2011) |
| "Melatonin deficiency has been postulated as an etiologic factors in adolescent idiopathic scoliosis (AIS)." | 3.76 | Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin. ( Cheng, JC; Hung, WY; Lee, SK; Man, GC; Ng, BK; Ng, TB; Qiu, Y; Wang, WW; Wong, JH; Yeung, BH, 2010) |
| "Pinealectomized chicken develops scoliosis probably due to the lack of melatonin." | 3.75 | The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model. ( Acaroglu, E; Akel, I; Alanay, A; Bozkurt, G; Kocak, O; Marcucio, R, 2009) |
| "The correlation of serum melatonin levels and curve progression in adolescent idiopathic scoliosis, and the effects of melatonin therapy in scoliotic patients with reduced levels of endogenous melatonin were studied in 40 adolescent patients with moderate to severe idiopathic scoliosis." | 3.75 | Serum melatonin levels in adolescent idiopathic scoliosis prediction and prevention for curve progression--a prospective study. ( Dubousset, J; Kimura, J; Machida, M; Yamada, T, 2009) |
| "The phenomenon of spinal deformity in the pinealectomized chicken has led researchers to postulate a disturbance of melatonin activity as a potential cause of adolescent idiopathic scoliosis (AIS)." | 3.75 | Pinealectomy in the chicken: a good model of scoliosis? ( Fagan, AB; Kennaway, DJ; Oakley, AP, 2009) |
| "The scoliosis observed in chickens after pinealectomy resembles that seen in humans with an adolescent idiopathic scoliosis, suggesting that melatonin deficiency may be responsible." | 3.74 | Pineal gland metabolism in patients with adolescent idiopathic scoliosis. ( Kim, SJ; Kim, YK; Lee, JS; Lee, SS; Suh, KT, 2007) |
| "The 2[125I]iodomelatonin binding assay was used to investigate the involvement of melatonin receptors in the development of scoliosis in pinealectomized chickens." | 3.73 | Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens. ( Cheung, KM; Leong, JC; Lu, DS; Poon, AM, 2006) |
| "The association between melatonin system and the spontaneous development of the spinal deformities in the Hereditary Lordoscoliotic Rabbit, the natural animal model for idiopathic scoliosis, was studied." | 3.72 | Implication for melatonin and its receptor in the spinal deformities of hereditary Lordoscoliotic Rabbits. ( Abe, M; Baba, I; Kanbara, K; Kin, A; Semoto, Y; Sobajima, S, 2003) |
| "To determine whether a dysfunction of the melatonin-signaling pathway in tissues targeted by this hormone is involved in adolescent idiopathic scoliosis." | 3.72 | Melatonin signaling dysfunction in adolescent idiopathic scoliosis. ( Angeloni, D; Azeddine, B; Forget, S; Fraschini, F; Grimard, G; Labelle, H; Moreau, A; Poitras, B; Rivard, CH; Wang, DS, 2004) |
| "To determine whether suppression of melatonin secretion without surgery in chickens can result in scoliosis development." | 3.72 | Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy. ( Cheung, KM; Leong, JC; Lu, DS; Luk, KD; Poon, AM; Wang, T, 2003) |
| "To determine whether transplantation of the pineal gland to the body wall musculature maintains serum melatonin levels at normal values and prevents the development of scoliosis." | 3.71 | Pineal transplantation after pinealectomy in young chickens has no effect on the development of scoliosis. ( Bagnall, KM; Beuerlein, M; Johnson, P; Moreau, M; Raso, VJ; Wilson, J, 2001) |
| "We might hypothesize that the high rate of pseudarthrosis after spinal fusion for neurofibromatous scoliosis is related to two factors: the absence of neurofibromin and melatonin deficiency." | 3.71 | The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis. ( Abdel-Wanis, ME; Kawahara, N, 2002) |
| "In adolescent idiopathic scoliosis, neither the presentation with a stable spinal deformity, nor presentation with a severe deformity requiring surgery is associated with melatonin deficiency." | 3.70 | Total 24-hour melatonin secretion in adolescent idiopathic scoliosis. A case-control study. ( Fagan, AB; Kennaway, DJ; Sutherland, AD, 1998) |
| "A radiographic examination of pinealectomized rats to observe the development of scoliosis and halt the condition by administration of melatonin." | 3.70 | Pathogenesis of idiopathic scoliosis. Experimental study in rats. ( Dubousset, J; Kimura, J; Machida, M; Miyashita, Y; Murai, I; Yamada, T, 1999) |
| "Scoliosis developed in all 40 pinealectomized chickens (control), whereas only 28 chickens in the 5-hydroxytryptophan-treated group (6 in severe, 22 in mild) had scoliosis developed." | 3.69 | Role of serotonin for scoliotic deformity in pinealectomized chicken. ( Dubousset, J; Kimura, J; Machida, M; Miyashita, Y; Murai, I; Yamada, T, 1997) |
| "Bone resorption is reduced by increased synthesis of osteoprogeterin (OPG), a decoy receptor that prevents receptor activator of NK-κB ligand (RANKL) in binding to its receptor." | 2.49 | Melatonin and the skeleton. ( Amstrup, AK; Mosekilde, L; Rejnmark, L; Sikjaer, T, 2013) |
| "Idiopathic scoliosis is a three-dimensional deformation of the spine." | 2.48 | Pathogenesis of idiopathic scoliosis: a review. ( Cugy, E; de Sèze, M, 2012) |
| "Scoliosis was determined from weekly radiographs." | 1.31 | The critical stage of pinealectomy surgery after which scoliosis is produced in young chickens. ( Bagnall, KM; Beuerlein, M; Greenhill, B; Mahood, J; Moreau, M; Raso, VJ; Wang, X; Wilson, J, 2001) |
| "The postoperative kyphosis and scoliosis angles were 30 degrees and 12 degrees, respectively." | 1.31 | The association of neurofibromatosis 1 and spinal deformity with primary hyperparathyroidism and osteomalacia: might melatonin have a role? ( Abdel-Wanis, ME; Kawahara, N; Tomita, K, 2001) |
| "Scoliosis was not observed in either the rats or the hamsters." | 1.30 | The production of scoliosis after pinealectomy in young chickens, rats, and hamsters. ( Bagnall, K; Mahood, J; Moreau, M; O'Kelly, C; Raso, J; Wang, X; Zhao, J, 1999) |
| "Scoliosis was assessed on weekly radiographs, and the Cobb angle was determined for all chickens in which scoliosis developed." | 1.30 | The effects of melatonin therapy on the development of scoliosis after pinealectomy in the chicken. ( Bagnall, K; Mahood, J; Moreau, M; Raso, VJ; Wang, X; Zhao, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (16.42) | 18.2507 |
| 2000's | 38 (56.72) | 29.6817 |
| 2010's | 15 (22.39) | 24.3611 |
| 2020's | 3 (4.48) | 2.80 |
| Authors | Studies |
|---|---|
| Gargano, G | 1 |
| Oliva, F | 1 |
| Migliorini, F | 1 |
| Maffulli, N | 1 |
| Li, J | 2 |
| Li, N | 1 |
| Chen, Y | 2 |
| Hui, S | 1 |
| Fan, J | 1 |
| Ye, B | 1 |
| Fan, Z | 1 |
| Zhang, J | 1 |
| Zhao, RC | 1 |
| Zhuang, Q | 1 |
| Peng, Y | 1 |
| Wang, SR | 1 |
| Qiu, GX | 1 |
| Zhang, JG | 1 |
| Zhuang, QY | 1 |
| Tao, L | 1 |
| Zhao, S | 1 |
| Tao, Z | 1 |
| Wen, K | 1 |
| Zhou, S | 1 |
| Da, W | 1 |
| Zhu, Y | 1 |
| Yang, S | 1 |
| Zheng, C | 1 |
| Jiang, J | 1 |
| Lu, F | 1 |
| Xia, X | 1 |
| Zhu, W | 1 |
| Jin, X | 1 |
| Ma, X | 1 |
| Liu, H | 1 |
| Liu, Z | 1 |
| Man, CW | 1 |
| Guo, J | 1 |
| Han, X | 1 |
| Hu, Z | 1 |
| Ng, TB | 4 |
| Zhao, Z | 1 |
| Wang, W | 1 |
| Chun, TC | 1 |
| Qiao, J | 1 |
| Shi, B | 1 |
| Xu, L | 1 |
| Bao, H | 1 |
| Jiang, Q | 1 |
| Lam, TP | 2 |
| Cheng, JCY | 1 |
| Qiu, Y | 5 |
| Zhu, Z | 1 |
| Amstrup, AK | 1 |
| Sikjaer, T | 1 |
| Mosekilde, L | 1 |
| Rejnmark, L | 1 |
| Goultidis, TT | 1 |
| Papavasiliou, KA | 1 |
| Petropoulos, AS | 1 |
| Philippopoulos, A | 1 |
| Kapetanos, GA | 1 |
| Man, GC | 3 |
| Wai, MG | 1 |
| Wang, WW | 3 |
| Jun, WW | 1 |
| Yim, AP | 1 |
| Yee, YA | 1 |
| Wong, JH | 3 |
| Ho, WJ | 1 |
| Bun, NT | 1 |
| Ping, LT | 1 |
| Lee, SK | 2 |
| Man, LS | 1 |
| Ng, BK | 3 |
| Wah, NB | 1 |
| Wang, CC | 1 |
| Chiu, WC | 1 |
| Yong, Q | 1 |
| Cheng, CY | 1 |
| Yiu, CJ | 1 |
| Lee, KM | 1 |
| Yeung, HY | 1 |
| Cheng, JC | 2 |
| Chen, C | 2 |
| Xu, C | 1 |
| Zhou, T | 1 |
| Gao, B | 1 |
| Zhou, H | 1 |
| Zhang, C | 1 |
| Huang, D | 1 |
| Su, P | 1 |
| Wu, JZ | 1 |
| Wu, WH | 1 |
| He, LJ | 1 |
| Ke, QF | 1 |
| Huang, L | 1 |
| Dai, ZS | 1 |
| Letellier, K | 2 |
| Azeddine, B | 4 |
| Parent, S | 2 |
| Labelle, H | 3 |
| Rompré, PH | 2 |
| Moreau, A | 5 |
| Moldovan, F | 3 |
| Burwell, RG | 1 |
| Dangerfield, PH | 1 |
| Moulton, A | 1 |
| Anderson, SI | 1 |
| Grivas, TB | 1 |
| Vasiliadis, ES | 1 |
| Rodopoulos, G | 1 |
| Shangguan, L | 1 |
| Fan, X | 1 |
| Luo, Z | 1 |
| Akoumé Ndong, MY | 1 |
| Franco, A | 1 |
| Roy-Gagnon, MH | 1 |
| Turgeon, I | 1 |
| Wang, D | 1 |
| Bagnall, KM | 4 |
| Poitras, B | 2 |
| Rivard, CH | 3 |
| Grimard, G | 2 |
| Ouellet, J | 1 |
| Akel, I | 2 |
| Kocak, O | 1 |
| Bozkurt, G | 1 |
| Alanay, A | 2 |
| Marcucio, R | 2 |
| Acaroglu, E | 2 |
| Machida, M | 10 |
| Dubousset, J | 8 |
| Yamada, T | 7 |
| Kimura, J | 7 |
| Fagan, AB | 2 |
| Kennaway, DJ | 3 |
| Oakley, AP | 1 |
| Yazici, M | 1 |
| Wang, B | 1 |
| Li, HB | 1 |
| Qiu, XS | 1 |
| Zhu, F | 1 |
| Sun, GQ | 1 |
| Wang, WJ | 1 |
| Yeung, BH | 1 |
| Hung, WY | 1 |
| Nelson, LM | 1 |
| Ward, K | 1 |
| Ogilvie, JW | 1 |
| Girardo, M | 1 |
| Bettini, N | 1 |
| Dema, E | 1 |
| Cervellati, S | 1 |
| Lombardi, G | 1 |
| Akoume, MY | 1 |
| Colombini, A | 1 |
| Banfi, G | 1 |
| de Sèze, M | 1 |
| Cugy, E | 1 |
| Ahn, UM | 1 |
| Ahn, NU | 1 |
| Nallamshetty, L | 1 |
| Buchowski, JM | 1 |
| Rose, PS | 1 |
| Miller, NH | 2 |
| Kostuik, JP | 1 |
| Sponseller, PD | 1 |
| Sobajima, S | 1 |
| Kin, A | 1 |
| Baba, I | 1 |
| Kanbara, K | 1 |
| Semoto, Y | 1 |
| Abe, M | 1 |
| Imashuku, S | 1 |
| Morimoto, Y | 1 |
| Morimoto, A | 1 |
| Yamamoto, T | 1 |
| Hibi, S | 1 |
| Todo, S | 1 |
| Cheung, KM | 3 |
| Lu, DS | 2 |
| Poon, AM | 3 |
| Wang, T | 2 |
| Luk, KD | 2 |
| Leong, JC | 3 |
| Wang, DS | 1 |
| Forget, S | 1 |
| Angeloni, D | 1 |
| Fraschini, F | 1 |
| Nette, F | 1 |
| Dolynchuk, K | 1 |
| Wang, X | 5 |
| Daniel, A | 1 |
| Demianczuk, C | 1 |
| Moreau, M | 7 |
| Raso, J | 2 |
| Mahood, J | 5 |
| Bagnall, K | 4 |
| Saito, M | 2 |
| Shibasaki, K | 1 |
| Turgut, M | 2 |
| Başaloğlu, HK | 1 |
| Yenisey, C | 2 |
| Ozsunar, Y | 1 |
| Carl, A | 1 |
| Tranmer, B | 1 |
| Hu, Y | 1 |
| Oyama, J | 1 |
| Murai, I | 3 |
| Kanazawa, K | 1 |
| Shiraishi, T | 1 |
| Yamagishi, M | 1 |
| Bozkurt, M | 1 |
| Ergin, FA | 1 |
| Biçakçi, T | 1 |
| Suh, KT | 1 |
| Lee, SS | 1 |
| Kim, SJ | 1 |
| Kim, YK | 1 |
| Lee, JS | 1 |
| Wang, da S | 1 |
| Imamura, Y | 2 |
| Iwaya, T | 1 |
| Hilibrand, AS | 1 |
| Blakemore, LC | 1 |
| Loder, RT | 1 |
| Greenfield, ML | 1 |
| Farley, FA | 1 |
| Hensinger, RN | 1 |
| Hariharan, M | 1 |
| Miyashita, Y | 3 |
| Raso, VJ | 6 |
| Hill, DL | 1 |
| Mahood, JK | 1 |
| Jiang, H | 2 |
| Russell, G | 1 |
| Bering, M | 1 |
| Buzzell, GR | 1 |
| Sutherland, AD | 1 |
| Zhao, J | 3 |
| O'Kelly, C | 1 |
| Sadat-Ali, M | 1 |
| al-Habdan, I | 1 |
| al-Othman, A | 1 |
| Brodner, W | 1 |
| Krepler, P | 1 |
| Nicolakis, M | 1 |
| Langer, M | 1 |
| Kaider, A | 1 |
| Lack, W | 1 |
| Waldhauser, F | 1 |
| Lowe, TG | 1 |
| Edgar, M | 1 |
| Margulies, JY | 1 |
| Reinker, KA | 1 |
| Illés, T | 1 |
| Horváth, G | 1 |
| Kennaway, D | 1 |
| Beuerlein, M | 2 |
| Wilson, J | 2 |
| Greenhill, B | 1 |
| Inoh, H | 1 |
| Kawakami, N | 1 |
| Matsuyama, Y | 1 |
| Aoki, T | 1 |
| Kanemura, T | 1 |
| Natsume, N | 1 |
| Iwata, H | 1 |
| Johnson, P | 1 |
| Abdel-Wanis, ME | 2 |
| Kawahara, N | 2 |
| Tomita, K | 1 |
| Porter, RW | 1 |
| Pompeiano, O | 1 |
| Manzoni, D | 1 |
| Miele, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Scoliosis Patients Aged 10-13 Years: Monitoring of Scoliosis by the Surface Topography[NCT02531945] | 125 participants (Actual) | Interventional | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for melatonin and Scoliosis
| Article | Year |
|---|---|
Melatonin and adolescent idiopathic scoliosis: The present evidence.
Topics: Adolescent; Humans; Melatonin; Scoliosis | 2022 |
Research progress on the etiology and pathogenesis of adolescent idiopathic scoliosis.
Topics: Adolescent; Biomechanical Phenomena; Bone Density; Cerebellum; Chromosome Aberrations; Epigenesis, G | 2020 |
Melatonin and the skeleton.
Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Resorption; Circadian Rhythm; Diseas | 2013 |
A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis.
Topics: Adolescent; Animals; Chickens; Disease Models, Animal; Female; Haplorhini; Humans; Male; Melatonin; | 2014 |
Etiologic theories of idiopathic scoliosis: autonomic nervous system and the leptin-sympathetic nervous system concept for the pathogenesis of adolescent idiopathic scoliosis.
Topics: Adolescent; Autonomic Nervous System; Body Mass Index; Female; Humans; Leptin; Melatonin; Posture; R | 2008 |
[Molecular and genetic aspects of idiopathic scoliosis. Blood test for idiopathic scoliosis].
Topics: Biomarkers; Blood Chemical Analysis; Genetic Predisposition to Disease; Humans; Mass Screening; Mela | 2009 |
The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis (AIS).
Topics: Adolescent; Animals; Disease Models, Animal; Humans; Melatonin; Scoliosis | 2011 |
Biochemistry of adolescent idiopathic scoliosis.
Topics: Adolescent; Blood Platelets; Bone and Bones; Calcium; Humans; Melatonin; Receptors, Melatonin; Scoli | 2011 |
Pathogenesis of idiopathic scoliosis: a review.
Topics: Adolescent; Animals; Biomechanical Phenomena; Bone Development; Calmodulin; Child; Disease Models, A | 2012 |
The etiology of adolescent idiopathic scoliosis.
Topics: Adolescent; Animals; Blood Platelets; Body Height; Contractile Proteins; Growth Hormone; Humans; Mel | 2002 |
Cause of idiopathic scoliosis.
Topics: Adolescent; Animals; Calmodulin; Child; Humans; Melatonin; Pineal Gland; Scoliosis; Serotonin | 1999 |
Etiology of idiopathic scoliosis: current trends in research.
Topics: Biomechanical Phenomena; Blood Platelets; Growth; Humans; Melatonin; Models, Theoretical; Muscle, Sk | 2000 |
Melatonin and development: physiology and pharmacology.
Topics: Adolescent; Adult; Aging; Child; Circadian Rhythm; Female; Fetus; Humans; Infant; Melatonin; Pregnan | 2000 |
[Possible role of the pineal gland in the pathogenesis of idiopathic scoliosis. Experimental and clinical studies].
Topics: Animals; Blood Platelets; Calmodulin; Chickens; Disease Models, Animal; Disease Progression; Growth | 2001 |
The pathogenesis of idiopathic scoliosis: uncoupled neuro-osseous growth?
Topics: Calmodulin; Child; Elastin; Free Radicals; Growth Substances; Humans; Melatonin; Scoliosis; Spinal C | 2001 |
Pineal gland hormone and idiopathic scoliosis: possible effect of melatonin on sleep-related postural mechanisms.
Topics: Animals; Biogenic Monoamines; Humans; Locus Coeruleus; Melatonin; Pineal Gland; Posture; Raphe Nucle | 2002 |
51 other studies available for melatonin and Scoliosis
| Article | Year |
|---|---|
SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells.
Topics: Adolescent; Bone Marrow; Case-Control Studies; Cell Differentiation; Down-Regulation; Female; Humans | 2019 |
Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonin‑induced osteoblasts.
Topics: Apoptosis; Cell Line; Endoplasmic Reticulum Stress; Humans; Melatonin; Osteoblasts; Scoliosis; Septi | 2020 |
The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model.
Topics: Animals; Disease Models, Animal; Melatonin; Random Allocation; Rats, Sprague-Dawley; Scoliosis; Tryp | 2017 |
The effect of exogenous melatonin on reducing scoliotic curvature and improving bone quality in melatonin-deficient C57BL/6J mice.
Topics: Animals; Bone Density; Cancellous Bone; Melatonin; Mice; Mice, Inbred C57BL; Osteoclasts; Scoliosis; | 2019 |
Higher levels of melatonin in early stages of adolescent idiopathic scoliosis: toward a new scenario.
Topics: Adolescent; Biomarkers; Case-Control Studies; Disease Progression; Female; Humans; Male; Melatonin; | 2014 |
Abnormal response of the proliferation and differentiation of growth plate chondrocytes to melatonin in adolescent idiopathic scoliosis.
Topics: Adolescent; Case-Control Studies; Cell Division; Cells, Cultured; Chondrocytes; Female; Growth Plate | 2014 |
Abnormal osteogenic and chondrogenic differentiation of human mesenchymal stem cells from patients with adolescent idiopathic scoliosis in response to melatonin.
Topics: Adolescent; Adult; Alkaline Phosphatase; Biomarkers; Case-Control Studies; Cell Differentiation; Cho | 2016 |
Effect of Melatonin and Calmodulin in an Idiopathic Scoliosis Model.
Topics: Animals; Calmodulin; Disease Models, Animal; Female; Humans; Lighting; Melatonin; Rats; Scoliosis; T | 2016 |
Estrogen cross-talk with the melatonin signaling pathway in human osteoblasts derived from adolescent idiopathic scoliosis patients.
Topics: Adenylyl Cyclases; Adolescent; Analysis of Variance; Blotting, Western; Case-Control Studies; Cells, | 2008 |
Aetiology of Idiopathic Scoliosis. What have we learned from school screening?
Topics: Adolescent; Age Factors; Anthropometry; Female; Humans; Melatonin; Menarche; Posture; School Health | 2008 |
The association between melatonin signaling dysfunction and idiopathic scoliosis.
Topics: Humans; Melatonin; Scoliosis; Signal Transduction | 2009 |
The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model.
Topics: Animals; Bone Density Conservation Agents; Calmodulin; Chickens; Disease Models, Animal; Dopamine An | 2009 |
Serum melatonin levels in adolescent idiopathic scoliosis prediction and prevention for curve progression--a prospective study.
Topics: Adolescent; Child; Circadian Rhythm; Disease Progression; Humans; Male; Melatonin; Predictive Value | 2009 |
Pinealectomy in the chicken: a good model of scoliosis?
Topics: Animals; Chickens; Disease Models, Animal; Intervertebral Disc; Melatonin; Pineal Gland; Reproducibi | 2009 |
Comparison of the melatonin and calmodulin in paravertebral muscle and platelets of patients with or without adolescent idiopathic scoliosis.
Topics: Adolescent; Adult; Blood Platelets; Calmodulin; Child; Enzyme-Linked Immunosorbent Assay; Female; Hu | 2009 |
[A preliminary study of melatonin signaling transduction pathway in BMSCs from adolescent idiopathic scoliosis patients].
Topics: Adolescent; Bone Marrow Cells; Case-Control Studies; Cells, Cultured; Child; Female; Humans; Male; M | 2010 |
Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin.
Topics: Adolescent; Adult; Alkaline Phosphatase; Analysis of Variance; Cell Differentiation; Cell Proliferat | 2010 |
Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis.
Topics: Acetylserotonin O-Methyltransferase; Adolescent; Arylalkylamine N-Acetyltransferase; Case-Control St | 2011 |
Implication for melatonin and its receptor in the spinal deformities of hereditary Lordoscoliotic Rabbits.
Topics: Age Factors; Animals; Disease Models, Animal; Lordosis; Melatonin; Molecular Sequence Data; Rabbits; | 2003 |
Pineal dysfunction (low melatonin production) as a cause of sudden death in a long-term survivor of Langerhans cell histiocytosis?
Topics: Adolescent; Death, Sudden; Histiocytosis, Langerhans-Cell; Humans; Male; Melatonin; Pineal Gland; Sc | 2003 |
Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy.
Topics: Animals; Body Weight; Chickens; Light; Melatonin; Pineal Gland; Postoperative Complications; Scolios | 2003 |
Melatonin signaling dysfunction in adolescent idiopathic scoliosis.
Topics: Adenylyl Cyclases; Adolescent; Cells, Cultured; Colforsin; Cyclic AMP; Female; Guanylyl Imidodiphosp | 2004 |
The effects of exposure to intense, 24 h light on the development of scoliosis in young chickens.
Topics: Adolescent; Animals; Chickens; Circadian Rhythm; Disease Models, Animal; Dose-Response Relationship, | 2002 |
Pathological mechanism of idiopathic scoliosis: experimental scoliosis in pinealectomized rats.
Topics: Animals; Disease Models, Animal; Lordosis; Male; Melatonin; Pineal Gland; Posture; Rats; Rats, Sprag | 2005 |
Surgical pinealectomy accelerates intervertebral disc degeneration process in chicken.
Topics: Animals; Chickens; Denervation; Disease Models, Animal; Disease Progression; Female; Intervertebral | 2006 |
The effect of pinealectomy on scoliosis development in young nonhuman primates.
Topics: Animals; Circadian Rhythm; Macaca mulatta; Melatonin; Neurosurgical Procedures; Pineal Gland; Postop | 2005 |
Bipedal ambulation induces experimental scoliosis in C57BL/6J mice with reduced plasma and pineal melatonin levels.
Topics: Animals; Hindlimb; Locomotion; Male; Melatonin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Pineal G | 2006 |
Experimental scoliosis in melatonin-deficient C57BL/6J mice without pinealectomy.
Topics: Animals; Melatonin; Mice; Mice, Inbred C57BL; Pineal Gland; Radiography; Scoliosis | 2006 |
Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens.
Topics: Animals; Cell Fractionation; Cell Membrane; Chickens; Circadian Rhythm; Disease Models, Animal; Iodi | 2006 |
Analysis of zinc and magnesium levels in pinealectomized chicks: roles on development of spinal deformity?
Topics: Animals; Animals, Newborn; Chickens; Female; Magnesium; Male; Melatonin; Pineal Gland; Scoliosis; Sp | 2006 |
Pineal gland metabolism in patients with adolescent idiopathic scoliosis.
Topics: Adolescent; Brain; Brain Mapping; Child; Female; Fluorodeoxyglucose F18; Glucose; Humans; Magnetic R | 2007 |
Molecular determinants of melatonin signaling dysfunction in adolescent idiopathic scoliosis.
Topics: Adenylyl Cyclases; Adolescent; Adult; Cells, Cultured; Child; Child, Preschool; Colforsin; Cyclic AM | 2007 |
Role of melatonin deficiency in the development of scoliosis in pinealectomised chickens.
Topics: Animals; Chickens; Melatonin; Pineal Gland; Scoliosis; Serotonin | 1995 |
The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis.
Topics: Adolescent; Case-Control Studies; Child; Circadian Rhythm; Data Interpretation, Statistical; Female; | 1996 |
Melatonin. A possible role in pathogenesis of adolescent idiopathic scoliosis.
Topics: Adolescent; Age Factors; Child; Circadian Rhythm; Female; Humans; Male; Matched-Pair Analysis; Melat | 1996 |
Melatonin levels in idiopathic scoliosis. Diurnal and nocturnal serum melatonin levels in girls with adolescent idiopathic scoliosis.
Topics: Adolescent; Child; Circadian Rhythm; Female; Humans; Melatonin; Osmolar Concentration; Reference Val | 1996 |
Role of serotonin for scoliotic deformity in pinealectomized chicken.
Topics: 5-Hydroxytryptophan; Animals; Chickens; Male; Melatonin; Pineal Gland; Posture; Radiography; Reflex; | 1997 |
Total 24-hour melatonin secretion in adolescent idiopathic scoliosis. A case-control study.
Topics: Adolescent; Case-Control Studies; Disease Progression; Female; Humans; Male; Melatonin; Pineal Gland | 1998 |
Changes in serum melatonin levels in response to pinealectomy in the chicken and its correlation with development of scoliosis.
Topics: Animals; Chickens; Circadian Rhythm; Melatonin; Pineal Gland; Scoliosis | 1998 |
The production of scoliosis after pinealectomy in young chickens, rats, and hamsters.
Topics: Animals; Animals, Newborn; Chickens; Cricetinae; Disease Models, Animal; Melatonin; Mesocricetus; Pi | 1999 |
The effects of melatonin therapy on the development of scoliosis after pinealectomy in the chicken.
Topics: Animals; Bone and Bones; Chickens; Disease Models, Animal; Melatonin; Pineal Gland; Scoliosis | 1999 |
Pathogenesis of idiopathic scoliosis. Experimental study in rats.
Topics: Animals; Disease Models, Animal; Humans; Locomotion; Male; Melatonin; Pineal Gland; Posture; Radiogr | 1999 |
Adolescent idiopathic scoliosis. Is low melatonin a cause?
Topics: Adolescent; Adult; Child; Female; Humans; Lumbar Vertebrae; Male; Melatonin; Radiography; Scoliosis; | 2000 |
Melatonin and adolescent idiopathic scoliosis.
Topics: Adolescent; Animals; Chickens; Circadian Rhythm; Female; Humans; Male; Melatonin; Pineal Gland; Risk | 2000 |
Pinealectomy and scoliosis.
Topics: Animals; Chickens; Melatonin; Pineal Gland; Postoperative Complications; Scoliosis; Time Factors | 2000 |
Cause of idiopathic scoliosis.
Topics: Adolescent; Adult; Aging; Antioxidants; Biomarkers; Child; Circadian Rhythm; Disease Progression; Hu | 2000 |
The critical stage of pinealectomy surgery after which scoliosis is produced in young chickens.
Topics: Animals; Chickens; Melatonin; Pineal Gland; Scoliosis | 2001 |
Correlation between the age of pinealectomy and the development of scoliosis in chickens.
Topics: Aging; Animals; Animals, Newborn; Chickens; Female; Melatonin; Neurosurgical Procedures; Osmolar Con | 2001 |
Pineal transplantation after pinealectomy in young chickens has no effect on the development of scoliosis.
Topics: Animals; Animals, Newborn; Chickens; Melatonin; Neurosurgical Procedures; Pineal Gland; Scoliosis; T | 2001 |
The association of neurofibromatosis 1 and spinal deformity with primary hyperparathyroidism and osteomalacia: might melatonin have a role?
Topics: Adenoma; Adult; Decompression, Surgical; Female; Humans; Hyperparathyroidism; Kyphosis; Melatonin; N | 2001 |
The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis.
Topics: Bone and Bones; Fibrosis; Humans; Melatonin; Models, Biological; Neurofibromatosis 1; Neurofibromin | 2002 |