melatonin has been researched along with Retinoblastoma in 9 studies
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The synthesis of melatonin in Xenopus retinas, chick and quail retinal cell cultures, and Y79 human retinoblastoma cells is stimulated by cAMP through a protein synthesis-dependent mechanism." | 7.69 | Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells. ( Florez, JC; Janavs, JL; Pierce, ME; Takahashi, JS, 1995) |
| "Y79 human retinoblastoma cells synthesize melatonin in cell culture thus providing a unique preparation for studying the regulation of melatonin biosynthesis in mammalian retinas." | 7.69 | RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells. ( Janavs, JL; Pierce, ME; Takahashi, JS, 1994) |
| "We studied the release of melatonin and the production of its precursors, 5-hydroxytryptophan and serotonin, in cultured Y79 human retinoblastoma cells." | 7.68 | Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate. ( Deng, MH; Lopez G-Coviella, I; Lynch, HJ; Wurtman, RJ, 1991) |
| "Melatonin is synthesized by cultured Y79 human retinoblastoma cells and is secreted into the medium." | 7.68 | Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells. ( Chader, GJ; Fletcher, RT; Kyritsis, AP; Wiechmann, AF, 1990) |
| "Two key enzymes involved in the synthesis of melatonin, hydroxyindole-O-methyltransferase (HIOMT) and arylalkylamine N-acetyltransferase (AA-NAT), are present in Y79 human retinoblastoma cells." | 3.70 | Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic AMP in Y79 human retinoblastoma cells. ( Burden, MA; Wiechmann, AF, 1999) |
| "The synthesis of melatonin in Xenopus retinas, chick and quail retinal cell cultures, and Y79 human retinoblastoma cells is stimulated by cAMP through a protein synthesis-dependent mechanism." | 3.69 | Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells. ( Florez, JC; Janavs, JL; Pierce, ME; Takahashi, JS, 1995) |
| "Y79 human retinoblastoma cells synthesize melatonin in cell culture thus providing a unique preparation for studying the regulation of melatonin biosynthesis in mammalian retinas." | 3.69 | RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells. ( Janavs, JL; Pierce, ME; Takahashi, JS, 1994) |
| "We studied the release of melatonin and the production of its precursors, 5-hydroxytryptophan and serotonin, in cultured Y79 human retinoblastoma cells." | 3.68 | Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate. ( Deng, MH; Lopez G-Coviella, I; Lynch, HJ; Wurtman, RJ, 1991) |
| "Melatonin is synthesized by cultured Y79 human retinoblastoma cells and is secreted into the medium." | 3.68 | Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells. ( Chader, GJ; Fletcher, RT; Kyritsis, AP; Wiechmann, AF, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, A | 1 |
| Zhu, X | 1 |
| Brown, B | 1 |
| Craft, CM | 1 |
| Janavs, JL | 3 |
| Florez, JC | 1 |
| Pierce, ME | 4 |
| Takahashi, JS | 4 |
| Hayashi, M | 1 |
| Itabashi, T | 1 |
| Moriyama, Y | 1 |
| Wiechmann, AF | 2 |
| Burden, MA | 1 |
| Deng, MH | 1 |
| Lopez G-Coviella, I | 1 |
| Lynch, HJ | 1 |
| Wurtman, RJ | 1 |
| Kyritsis, AP | 1 |
| Fletcher, RT | 1 |
| Chader, GJ | 1 |
| Barker, D | 1 |
| Harrington, J | 1 |
9 other studies available for melatonin and Retinoblastoma
| Article | Year |
|---|---|
Melatonin enhances retinoic acid induction of cone arrestin gene expression in retinoblastoma cells.
Topics: Arrestin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regula | 2003 |
Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells.
Topics: Camptothecin; Colforsin; Humans; Immunoblotting; Melatonin; Molecular Weight; Neoplasm Proteins; Ret | 1995 |
RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells.
Topics: Amidohydrolases; Anisomycin; Arylamine N-Acetyltransferase; Calcium; Camptothecin; Colforsin; Cyclic | 1994 |
D-aspartate is present in human retinoblastoma Y79 cells.
Topics: Animals; Aspartic Acid; Clone Cells; Fluorescent Antibody Technique, Indirect; Humans; Immunohistoch | 1999 |
Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic AMP in Y79 human retinoblastoma cells.
Topics: Acetylserotonin O-Methyltransferase; Arylamine N-Acetyltransferase; Base Sequence; Bucladesine; Buty | 1999 |
Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate.
Topics: 5-Hydroxytryptophan; Analysis of Variance; Butyrates; Butyric Acid; Cell Line; Colforsin; Dopamine; | 1991 |
N-acetyltransferase and protein synthesis modulate melatonin production by Y79 human retinoblastoma cells.
Topics: Acetylserotonin O-Methyltransferase; Anisomycin; Arylamine N-Acetyltransferase; Cell Line; Colforsin | 1991 |
Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells.
Topics: Acetylserotonin O-Methyltransferase; Arylamine N-Acetyltransferase; Bucladesine; Butyrates; Butyric | 1990 |
Cyclic AMP-dependent melatonin production in Y79 human retinoblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 5-Hydroxytryptophan; 8-Bromo Cyclic Adenosine Monophosphate; Colforsin; | 1989 |