melatonin has been researched along with Retinal Degeneration in 29 studies
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the potential of a poly(lactic-co-glycolic acid) (PLGA)-based slow release formulation of glial cell line-derived neurotrophic factor (GDNF) alone or in combination with melatonin to rescue photoreceptors in a mouse model of retinal degeneration." | 3.88 | Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice. ( Arranz-Romera, A; Baranov, P; Bravo-Osuna, I; García-Caballero, C; Herrero-Vanrell, R; Lieppman, B; Molina-Martínez, IT; Young, M, 2018) |
| "This study focuses on the effects of retinal degeneration on the circadian patterns of P23H rats, as well as on the effect of exogenous melatonin administration." | 3.77 | Circadian dysfunction in P23H rhodopsin transgenic rats: effects of exogenous melatonin. ( Cuenca, N; Esquiva, G; Lax, P; Madrid, JA; Otalora, BB; Rol, Mde L, 2011) |
| "The inability of retinal pigment epithelium to phagocytose shed photoreceptor disks is a cause of retinal degeneration in the Royal College of Surgeons rat; retinal pigment epithelial phagocytosis and disk shedding are regulated by the diurnal rhythm of retinal melatonin level." | 3.68 | Diurnal variations in the electroretinographic c-wave and retinal melatonin content in rats with inherited retinal dystrophy. ( Hawlina, M; Ikeda, H; Jenkins, HG, 1992) |
| "The effects of melatonin and a related 5-methoxy-indole, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THBC) were investigated in rats on the development of retinal degeneration in presence of high intensity illumination (HII)." | 3.67 | Effects of melatonin and 6-methoxy-tetrahydro-beta-carboline in light induced retinal damage: a computerized morphometric method. ( Aho, IM; Gynther, J; Kari, E; Leino, M; Markkanen, S, 1984) |
| "Melatonin treatment significantly delayed photoreceptor loss and reduced the number of apoptotic photoreceptors." | 1.31 | Melatonin delays photoreceptor degeneration in the rds/rds mouse. ( Aleman, TS; Bennett, J; Cideciyan, AV; Jacobson, SG; Liang, FQ, 2001) |
| "Luzindole-treated eyes had ERG b-wave thresholds of 2." | 1.30 | The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat. ( Bush, RA; Iuvone, PM; Sieving, PA; Sugawara, T, 1998) |
| "Melatonin-treated rats developed more severe impairment of retinal structures compared with controls." | 1.26 | The role of melatonin and dopamine in retinal physiology. ( Bubenik, GA; Purtill, RA, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 10 (34.48) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Oh, A | 1 |
| Foster, ML | 1 |
| Lunn, KF | 1 |
| Mowat, FM | 1 |
| Wiechmann, AF | 1 |
| Martin, TA | 1 |
| Horb, ME | 1 |
| Bessone, CDV | 1 |
| Martinez, SM | 1 |
| Luna, JD | 1 |
| Marquez, MA | 1 |
| Ramírez, ML | 1 |
| Allemandi, DA | 2 |
| Carpentieri, ÁR | 2 |
| Quinteros, DA | 2 |
| Leclercq, B | 1 |
| Hicks, D | 1 |
| Laurent, V | 1 |
| Hurley, MJ | 1 |
| Deacon, RMJ | 1 |
| Beyer, K | 1 |
| Ioannou, E | 1 |
| Ibáñez, A | 1 |
| Teeling, JL | 1 |
| Cogram, P | 1 |
| García-Caballero, C | 1 |
| Lieppman, B | 1 |
| Arranz-Romera, A | 1 |
| Molina-Martínez, IT | 1 |
| Bravo-Osuna, I | 1 |
| Young, M | 1 |
| Baranov, P | 1 |
| Herrero-Vanrell, R | 1 |
| Del Valle Bessone, C | 1 |
| Fajreldines, HD | 1 |
| de Barboza, GED | 1 |
| Tolosa de Talamoni, NG | 1 |
| Baba, K | 2 |
| Pozdeyev, N | 1 |
| Mazzoni, F | 1 |
| Contreras-Alcantara, S | 1 |
| Liu, C | 2 |
| Kasamatsu, M | 1 |
| Martinez-Merlos, T | 1 |
| Strettoi, E | 1 |
| Iuvone, PM | 3 |
| Tosini, G | 4 |
| Lax, P | 1 |
| Otalora, BB | 1 |
| Esquiva, G | 1 |
| Rol, Mde L | 1 |
| Madrid, JA | 1 |
| Cuenca, N | 1 |
| Hwang, CK | 1 |
| Fornaro, P | 1 |
| Calabria, G | 1 |
| Corallo, G | 1 |
| Picotti, GB | 1 |
| Sakamoto, K | 1 |
| Dinet, V | 1 |
| Ansari, N | 1 |
| Torres-Farfan, C | 1 |
| Korf, HW | 1 |
| Grewal, R | 1 |
| Organisciak, D | 1 |
| Wong, P | 1 |
| Leino, M | 1 |
| Aho, IM | 1 |
| Kari, E | 1 |
| Gynther, J | 1 |
| Markkanen, S | 1 |
| Bubenik, GA | 1 |
| Purtill, RA | 1 |
| Hankins, M | 1 |
| Ikeda, H | 2 |
| Falcon, J | 1 |
| Poeggeler, BH | 1 |
| Barlow-Walden, LR | 1 |
| Reiter, RJ | 1 |
| Saarela, S | 1 |
| Menendez-Pelaez, A | 1 |
| Yaga, K | 1 |
| Manchester, LC | 1 |
| Chen, LD | 1 |
| Tan, DX | 1 |
| Oishi, T | 1 |
| Mohri, Y | 1 |
| Kaneko, T | 1 |
| Sasaki, M | 1 |
| Hattori, A | 1 |
| Obara, Y | 1 |
| Masuda, A | 1 |
| Pozdeev, NV | 1 |
| Etingof, RN | 1 |
| Djamgoz, MB | 1 |
| Hankins, MW | 1 |
| Hirano, J | 1 |
| Archer, SN | 1 |
| Menaker, M | 1 |
| Sugawara, T | 1 |
| Sieving, PA | 1 |
| Bush, RA | 1 |
| Lucas, RJ | 2 |
| Foster, RG | 2 |
| Liang, FQ | 1 |
| Aleman, TS | 1 |
| Cideciyan, AV | 1 |
| Jacobson, SG | 1 |
| Bennett, J | 1 |
| Freedman, MS | 1 |
| Lupi, D | 1 |
| Munoz, M | 1 |
| David-Gray, ZK | 1 |
| Hawlina, M | 1 |
| Jenkins, HG | 1 |
| Mironova, EM | 1 |
| Pavlova, ON | 1 |
| Ronkina, TI | 1 |
4 reviews available for melatonin and Retinal Degeneration
| Article | Year |
|---|---|
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases.
Topics: Alzheimer Disease; Animals; Atherosclerosis; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug | 2018 |
Melatonin: an underappreciated player in retinal physiology and pathophysiology.
Topics: Circadian Rhythm; Humans; Melatonin; Receptors, Melatonin; Retina; Retinal Degeneration | 2012 |
Factors underlying circadian dependent susceptibility to light induced retinal damage.
Topics: Animals; Circadian Rhythm; Dark Adaptation; Darkness; Disease Susceptibility; Dopamine; Humans; Ligh | 2006 |
Neurobiology of retinal dopamine in relation to degenerative states of the tissue.
Topics: Aging; Animals; Dopamine; Humans; Mammals; Melatonin; Parkinson Disease; Retina; Retinal Degeneratio | 1997 |
25 other studies available for melatonin and Retinal Degeneration
| Article | Year |
|---|---|
Circulating neurohormone imbalances in canine sudden acquired retinal degeneration syndrome and canine pituitary-dependent hypercortisolism.
Topics: Animals; Case-Control Studies; Dog Diseases; Dogs; Dopamine; Melatonin; Pituitary ACTH Hypersecretio | 2019 |
CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Circadian Rhythm; CRISPR-Cas Systems; F | 2020 |
Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits.
Topics: Animals; Antioxidants; Cellulose; Disease Models, Animal; Drug Compounding; Melatonin; Microscopy, E | 2020 |
Photoperiod integration in C3H rd1 mice.
Topics: Animals; Circadian Rhythm; Melatonin; Mice; Mice, Inbred C3H; Photoperiod; Retinal Degeneration; Sup | 2021 |
Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Combinations; Drug Compounding; D | 2018 |
Protective role of melatonin on retinal ganglionar cell: In vitro an in vivo evidences.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chick Embryo; Glutamic Acid; In Vitro Techn | 2019 |
Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.
Topics: Adaptation, Biological; Aging; Animals; Cell Survival; Darkness; Electroretinography; Gene Expressio | 2009 |
Circadian dysfunction in P23H rhodopsin transgenic rats: effects of exogenous melatonin.
Topics: Animals; Animals, Genetically Modified; Antioxidants; Body Temperature; Circadian Rhythm; Electroret | 2011 |
Pathogenesis of degenerative retinopathies induced by thioridazine and other antipsychotics: a dopamine hypothesis.
Topics: Animals; Antipsychotic Agents; Dopamine; Dopamine Antagonists; Humans; Melatonin; Receptors, Dopamin | 2002 |
Circadian rhythms in the retina of rats with photoreceptor degeneration.
Topics: Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Disease Models, Animal; Excitatory Amino A | 2004 |
Clock gene expression in the retina of melatonin-proficient (C3H) and melatonin-deficient (C57BL) mice.
Topics: Animals; Biological Clocks; Cell Cycle Proteins; Cryptochromes; Cyclic AMP Response Element-Binding | 2007 |
Effects of melatonin and 6-methoxy-tetrahydro-beta-carboline in light induced retinal damage: a computerized morphometric method.
Topics: Animals; Anticonvulsants; Carbolines; Indoles; Light; Male; Melatonin; Radiation Injuries; Rats; Rat | 1984 |
The role of melatonin and dopamine in retinal physiology.
Topics: Animals; Bromocriptine; Dopamine; Male; Melatonin; Prolactin; Rats; Receptors, Dopamine; Retina; Ret | 1980 |
Early abnormalities of retinal dopamine pathways in rats with hereditary retinal dystrophy.
Topics: Animals; Benzazepines; Dopamine; Dopamine D2 Receptor Antagonists; Electrophysiology; Fluorescent Dy | 1994 |
[Photoreceptor cells, circadian oscillators and control of the rhythmic production of melatonin. Perspectives].
Topics: Adenosine; Atrial Natriuretic Factor; Catecholamines; Circadian Rhythm; Humans; Melatonin; Photorece | 1993 |
Red-light-induced suppression of melatonin synthesis is mediated by N-methyl-D-aspartate receptor activation in retinally normal and retinally degenerate rats.
Topics: Animals; Arylamine N-Acetyltransferase; Dizocilpine Maleate; Dose-Response Relationship, Radiation; | 1995 |
Retinal melatonin is not involved in corneal mitotic rhythms in the Japanese quail: effects of formoguanamine hydrochloride and eye-lid suture.
Topics: Animals; Circadian Rhythm; Cornea; Coturnix; Dark Adaptation; Epithelial Cells; Epithelium; Eye; Eye | 1996 |
[Melatonin biosynthesis in the epiphysis during early postnatal ontogenesis in healthy persons and in patients with hereditary retinal degeneration].
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Melatonin; Norepinephrine; Pineal Gland; Rats; | 1997 |
The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration.
Topics: Animals; Biological Clocks; Male; Melatonin; Mice; Mice, Inbred Strains; Photoreceptor Cells; Radioi | 1998 |
The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat.
Topics: Animals; Dark Adaptation; Electroretinography; Light; Male; Melatonin; Photoreceptor Cells; Radiatio | 1998 |
Neither functional rod photoreceptors nor rod or cone outer segments are required for the photic inhibition of pineal melatonin.
Topics: Animals; Circadian Rhythm; Genotype; Light; Melatonin; Mice; Mice, Inbred C3H; Mutation; Pineal Glan | 1999 |
Melatonin delays photoreceptor degeneration in the rds/rds mouse.
Topics: Animals; Apoptosis; Cell Count; Cell Nucleus; Electroretinography; In Situ Nick-End Labeling; Melato | 2001 |
Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice.
Topics: Animals; Circadian Rhythm; Melatonin; Mice; Mice, Transgenic; Phenotype; Photoreceptor Cells; Pineal | 2001 |
Diurnal variations in the electroretinographic c-wave and retinal melatonin content in rats with inherited retinal dystrophy.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electroretinography; Melatonin; Phagocytosis; Pig | 1992 |
[The early diagnosis, evaluation of treatment results and modelling of certain aspects of the pathogenesis of retinal dystrophy].
Topics: Adult; Aged; Animals; Conjunctiva; Disease Models, Animal; Drug Evaluation; Drug Evaluation, Preclin | 1989 |