melatonin has been researched along with Restless Legs Syndrome in 15 studies
Restless Legs Syndrome: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The precise etiology of the restless legs syndrome (RLS) is unknown." | 5.32 | Urinary 6-hydroxy-melatonin-sulfate excretion and circadian rhythm in patients with restless legs syndrome. ( Auff, E; Sycha, T; Tribl, GG; Waldhauser, F; Zeitlhofer, J, 2003) |
| "A close temporal relationship was shown between the onset of melatonin secretion at night and the worsening of restless legs syndrome (RLS) symptoms, suggesting that melatonin may play a role in the genesis of this phenomenon." | 3.76 | Effects of melatonin and bright light administration on motor and sensory symptoms of RLS. ( Adam, B; Desautels, A; Dumont, M; Lavigne, G; Montplaisir, J; Petit, D; Whittom, S, 2010) |
| " Switching to morning dosing or to an alternative drug may help." | 2.82 | [Sleep disorders in patients with a neurocognitive disorder]. ( Carrier, J; Dang-Vu, TT; Moderie, C, 2022) |
| "While some sleep disorders are more challenging to treat, most can be easily managed with adequate interventions." | 2.61 | Sleep Disorders. ( K Pavlova, M; Latreille, V, 2019) |
| "Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional." | 2.50 | Restless legs syndrome and pain disorders: what's in common? ( Delgado Rodrigues, RN; Goulart, LI; Prieto Peres, MF, 2014) |
| "There are specific sleep disorders (other than insomnia) for which pharmacotherapy plus behavioral strategies are warranted." | 2.46 | Pharmacotherapy in pediatric sleep disorders. ( Garbutt, A; Weiss, SK, 2010) |
| "Melatonin may prove to be an alternative therapy for PLMS." | 2.41 | Restless legs syndrome and periodic limb movements of sleep: fact, fad, and fiction. ( Patel, S, 2002) |
| "To investigate the presence of Restless Legs Syndrome (RLS) in Cluster Headache (CH) patients compared to headache-free controls." | 1.37 | Cluster headache patients are not affected by restless legs syndrome: an observational study. ( Daniela, C; Eliana, M; Florindo, D; Gabriella, M; Gennaro, B; Gerardo, C; Giulio, C; Vincenzo, T; Vittorio, P, 2011) |
| "Effective treatments now exist for many sleep disorders, such as OSA and RLS, and a major breakthrough in the treatment of narcolepsy seems imminent." | 1.32 | Sleep disorders. ( Fisch, BJ; Olejniczak, PW, 2003) |
| "The precise etiology of the restless legs syndrome (RLS) is unknown." | 1.32 | Urinary 6-hydroxy-melatonin-sulfate excretion and circadian rhythm in patients with restless legs syndrome. ( Auff, E; Sycha, T; Tribl, GG; Waldhauser, F; Zeitlhofer, J, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Moderie, C | 1 |
| Carrier, J | 1 |
| Dang-Vu, TT | 1 |
| K Pavlova, M | 1 |
| Latreille, V | 1 |
| Amos, LB | 1 |
| Grekowicz, ML | 1 |
| Kuhn, EM | 1 |
| Olstad, JD | 1 |
| Collins, MM | 1 |
| Norins, NA | 1 |
| D'Andrea, LA | 1 |
| Barun, B | 1 |
| Goulart, LI | 1 |
| Delgado Rodrigues, RN | 1 |
| Prieto Peres, MF | 1 |
| Whittom, S | 1 |
| Dumont, M | 2 |
| Petit, D | 1 |
| Desautels, A | 1 |
| Adam, B | 1 |
| Lavigne, G | 1 |
| Montplaisir, J | 2 |
| Florindo, D | 1 |
| Daniela, C | 1 |
| Giulio, C | 1 |
| Vittorio, P | 1 |
| Gabriella, M | 1 |
| Vincenzo, T | 1 |
| Eliana, M | 1 |
| Gerardo, C | 1 |
| Gennaro, B | 1 |
| Weiss, SK | 1 |
| Garbutt, A | 1 |
| Koo, BB | 1 |
| Patel, S | 1 |
| Olejniczak, PW | 1 |
| Fisch, BJ | 1 |
| Tribl, GG | 1 |
| Waldhauser, F | 1 |
| Sycha, T | 1 |
| Auff, E | 1 |
| Zeitlhofer, J | 1 |
| Kunz, D | 1 |
| Mahlberg, R | 1 |
| Müller, C | 1 |
| Tilmann, A | 1 |
| Bes, F | 1 |
| Michaud, M | 1 |
| Selmaoui, B | 1 |
| Paquet, J | 1 |
| Fantini, ML | 1 |
| Garcia-Borreguero, D | 1 |
| Serrano, C | 1 |
| Larrosa, O | 1 |
| Granizo, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Influence of an Osteopathic Treatment Protocol on the Improvement of Sleep: a Double-blind Randomized Controlled Trial[NCT05899972] | 50 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for melatonin and Restless Legs Syndrome
| Article | Year |
|---|---|
[Sleep disorders in patients with a neurocognitive disorder].
Topics: Alzheimer Disease; Chronobiology Disorders; Humans; Melatonin; REM Sleep Behavior Disorder; Restless | 2022 |
Sleep Disorders.
Topics: Central Nervous System Depressants; Central Nervous System Stimulants; Chronobiology Disorders; Cogn | 2019 |
Pathophysiological background and clinical characteristics of sleep disorders in multiple sclerosis.
Topics: Animals; Fatigue; Humans; Melatonin; Multiple Sclerosis; Narcolepsy; Restless Legs Syndrome; Sleep W | 2013 |
Restless legs syndrome and pain disorders: what's in common?
Topics: Calcium Channel Blockers; Diagnosis, Differential; Dopamine Agonists; Fibromyalgia; gamma-Aminobutyr | 2014 |
Pharmacotherapy in pediatric sleep disorders.
Topics: Adolescent; Central Nervous System Depressants; Child; GABA-A Receptor Agonists; Histamine Antagonis | 2010 |
Restless legs syndrome and periodic limb movements of sleep: fact, fad, and fiction.
Topics: Anemia, Iron-Deficiency; Anticonvulsants; Humans; Melatonin; Nocturnal Myoclonus Syndrome; Renal Ins | 2002 |
2 trials available for melatonin and Restless Legs Syndrome
| Article | Year |
|---|---|
Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.
Topics: Adult; Aged; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Melatonin; Middle Aged; Na | 2004 |
Circadian effects of dopaminergic treatment in restless legs syndrome.
Topics: Adult; Circadian Rhythm; Dopamine Agents; Female; Humans; Levodopa; Lighting; Male; Melatonin; Middl | 2004 |
7 other studies available for melatonin and Restless Legs Syndrome
| Article | Year |
|---|---|
Treatment of pediatric restless legs syndrome.
Topics: Adolescent; Amines; Analgesics; Anticonvulsants; Antioxidants; Benzothiazoles; Child; Child, Prescho | 2014 |
Effects of melatonin and bright light administration on motor and sensory symptoms of RLS.
Topics: Adult; Female; Humans; Immobilization; Male; Melatonin; Middle Aged; Phototherapy; Psychomotor Perfo | 2010 |
Cluster headache patients are not affected by restless legs syndrome: an observational study.
Topics: Adult; Aged; Case-Control Studies; Circadian Rhythm; Cluster Headache; Cross-Sectional Studies; Fema | 2011 |
Restless legs syndrome: relationship between prevalence and latitude.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Americas; Asia; Cross-Cultural Comparison; Cross-Section | 2012 |
Sleep disorders.
Topics: Adult; Aged; Antioxidants; Cheyne-Stokes Respiration; Chronobiology Disorders; Chronotherapy; Disord | 2003 |
Urinary 6-hydroxy-melatonin-sulfate excretion and circadian rhythm in patients with restless legs syndrome.
Topics: Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Restless Legs Syndrome | 2003 |
Circadian rhythm of restless legs syndrome: relationship with biological markers.
Topics: Adult; Arousal; Biomarkers; Body Temperature; Chi-Square Distribution; Circadian Rhythm; Demography; | 2004 |