melatonin has been researched along with Renal Insufficiency, Chronic in 25 studies
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This review article aimed to present the role of melatonin in this direction, by providing an overview of melatonin's physiology followed by its effect as a therapeutic agent in arterial hypertension and T2DM." | 5.22 | The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal? ( Kalaitzidis, RG; Theofilis, P; Vordoni, A, 2022) |
| "The melatonin levels decreased with aging despite not reaching statistical significance, and the decrease was more evident in males than in females (40." | 3.80 | Melatonin and the Charlson Comorbidity Index (CCI): the Treviso Longeva (Trelong) study. ( Albani, D; Boldrini, P; Caberlotto, L; Di Giorgi, E; Durante, E; Flores-Obando, R; Forloni, G; Frigato, A; Gallucci, M; Mazzuco, S; Ongaro, F; Siculi, M; Taioli, E; Zanardo, A, 2014) |
| "Melatonin is a neurohormone that is mainly secreted by the pineal gland." | 3.01 | Melatonin Treatment in Kidney Diseases. ( Markowska, M; Niemczyk, S; Romejko, K, 2023) |
| "Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes." | 2.66 | The roles of melatonin on kidney injury in obese and diabetic conditions. ( Lungkaphin, A; Promsan, S, 2020) |
| "Melatonin is a hormone produced by the pineal gland, predominantly at night, and plays a pivotal role in regulating the circadian rhythm as well as a variety of biological functions, including anti-inflammation, anti-oxidation, inhibition of sympathetic nerve activity, and preservation of endothelial cell function." | 2.61 | The pivotal role of melatonin in ameliorating chronic kidney disease by suppression of the renin-angiotensin system in the kidney. ( Ishigaki, S; Isobe, S; Ohashi, N, 2019) |
| "Treatment with melatonin significantly reversed these abnormalities." | 1.48 | Melatonin ameliorates intrarenal renin-angiotensin system in a 5/6 nephrectomy rat model. ( Fujikura, T; Ishigaki, S; Isobe, S; Iwakura, T; Kato, A; Matsuyama, T; Miyajima, H; Ohashi, N; Tsuji, N; Tsuji, T; Yasuda, H, 2018) |
| "Melatonin is a hormone regulating the circadian rhythm, and has multiple functions such as anti-oxidant and anti-adrenergic effects and enhancement of NO bioavailability." | 1.43 | Impaired endogenous nighttime melatonin secretion relates to intrarenal renin-angiotensin system activation and renal damage in patients with chronic kidney disease. ( Ishigaki, S; Isobe, S; Iwakura, T; Kato, A; Miyajima, H; Ohashi, N; Ono, M; Sakao, Y; Tsuji, N; Tsuji, T; Yasuda, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (60.00) | 24.3611 |
| 2020's | 10 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eftekhar Vaghefi, SS | 1 |
| Mousavi, F | 1 |
| Khaksari, M | 1 |
| Asadikaram, G | 1 |
| Soltani, Z | 1 |
| Theofilis, P | 1 |
| Vordoni, A | 1 |
| Kalaitzidis, RG | 1 |
| Markowska, M | 1 |
| Niemczyk, S | 1 |
| Romejko, K | 1 |
| Tang, KS | 1 |
| Ho, CY | 1 |
| Hsu, CN | 1 |
| Tain, YL | 1 |
| Yoon, YM | 3 |
| Lee, JH | 4 |
| Song, KH | 1 |
| Noh, H | 2 |
| Lee, SH | 4 |
| Petrova, A | 1 |
| Kondratiuk, V | 1 |
| Karpenko, O | 1 |
| Ostashevska, T | 1 |
| Krasiuk, E | 1 |
| Promsan, S | 1 |
| Lungkaphin, A | 1 |
| Go, G | 2 |
| Yun, CW | 1 |
| Lim, JH | 2 |
| Movahhed, SMM | 1 |
| Yoon, S | 1 |
| Lee, G | 1 |
| Ishigaki, S | 4 |
| Ohashi, N | 4 |
| Matsuyama, T | 2 |
| Isobe, S | 4 |
| Tsuji, N | 2 |
| Iwakura, T | 2 |
| Fujikura, T | 2 |
| Tsuji, T | 3 |
| Kato, A | 3 |
| Miyajima, H | 2 |
| Yasuda, H | 3 |
| Santamaría, R | 1 |
| Díaz-Tocados, JM | 1 |
| Pendón-Ruiz de Mier, MV | 1 |
| Robles, A | 1 |
| Salmerón-Rodríguez, MD | 1 |
| Ruiz, E | 1 |
| Vergara, N | 1 |
| Aguilera-Tejero, E | 1 |
| Raya, A | 1 |
| Ortega, R | 1 |
| Felsenfeld, A | 1 |
| Muñoz-Castañeda, JR | 1 |
| Martín-Malo, A | 1 |
| Aljama, P | 1 |
| Rodríguez, M | 1 |
| Han, YS | 1 |
| Kim, SM | 1 |
| Jung, SK | 1 |
| Saberi, K | 1 |
| Pasbakhsh, P | 1 |
| Omidi, A | 1 |
| Borhani-Haghighi, M | 1 |
| Nekoonam, S | 1 |
| Omidi, N | 1 |
| Ghasemi, S | 1 |
| Kashani, IR | 1 |
| Sato, T | 1 |
| Nagasawa, Y | 1 |
| Hasuike, Y | 1 |
| Kuragano, T | 1 |
| Ishihara, M | 1 |
| Chen, DQ | 1 |
| Feng, YL | 1 |
| Chen, L | 1 |
| Liu, JR | 1 |
| Wang, M | 1 |
| Vaziri, ND | 1 |
| Zhao, YY | 1 |
| Rahman, A | 1 |
| Hasan, AU | 1 |
| Kobori, H | 1 |
| Hameed, EN | 1 |
| Hadi Al Tukmagi, HF | 1 |
| Allami, HCA | 1 |
| Hrenák, J | 2 |
| Arendášová, K | 1 |
| Rajkovičová, R | 1 |
| Aziriová, S | 2 |
| Repová, K | 2 |
| Krajčírovičová, K | 1 |
| Celec, P | 1 |
| Kamodyová, N | 1 |
| Bárta, A | 1 |
| Adamcová, M | 1 |
| Paulis, L | 2 |
| Simko, F | 2 |
| Gallucci, M | 1 |
| Flores-Obando, R | 1 |
| Mazzuco, S | 1 |
| Ongaro, F | 1 |
| Di Giorgi, E | 1 |
| Boldrini, P | 1 |
| Durante, E | 1 |
| Frigato, A | 1 |
| Albani, D | 1 |
| Forloni, G | 1 |
| Zanardo, A | 1 |
| Siculi, M | 1 |
| Caberlotto, L | 1 |
| Taioli, E | 1 |
| Nagtegaal, EJ | 1 |
| Reiter, RJ | 1 |
| Ono, M | 1 |
| Sakao, Y | 1 |
| Russcher, M | 1 |
| Koch, B | 1 |
| Nagtegaal, E | 1 |
| van der Putten, K | 1 |
| ter Wee, P | 1 |
| Gaillard, C | 1 |
8 reviews available for melatonin and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal?
Topics: Diabetes Mellitus, Type 2; Humans; Hypertension; Melatonin; Renal Insufficiency, Chronic; Renin-Angi | 2022 |
Melatonin Treatment in Kidney Diseases.
Topics: Antioxidants; Humans; Kidney; Melatonin; Quality of Life; Renal Insufficiency, Chronic | 2023 |
Melatonin and Kidney Health: From Fetal Stage to Later Life.
Topics: Animals; Circadian Rhythm; Kidney; Melatonin; Models, Animal; Pineal Gland; Renal Insufficiency, Chr | 2023 |
The roles of melatonin on kidney injury in obese and diabetic conditions.
Topics: Adipocytes; Adipose Tissue; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cytokines; D | 2020 |
Possible benefits of exogenous melatonin for individuals on dialysis: a narrative review on potential mechanisms and clinical implications.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Humans; Inflammation; Melatonin; Oxidative Stress; | 2021 |
The pivotal role of melatonin in ameliorating chronic kidney disease by suppression of the renin-angiotensin system in the kidney.
Topics: Animals; Antioxidants; Circadian Rhythm; Humans; Hypertension, Renal; Kidney; Melatonin; Renal Insuf | 2019 |
Melatonin and renal protection: novel perspectives from animal experiments and human studies (review).
Topics: Animals; Humans; Kidney; Melatonin; Models, Animal; Renal Insufficiency, Chronic; Signal Transductio | 2015 |
The role of melatonin treatment in chronic kidney disease.
Topics: Blood Pressure; Chronobiology Disorders; Chronotherapy; Humans; Inflammation Mediators; Kidney Failu | 2012 |
1 trial available for melatonin and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Melatonin Improves Erythropoietin Hyporesponsiveness via Suppression of Inflammation.
Topics: Anemia; Antioxidants; Biomarkers; Erythropoietin; Female; Hematinics; Humans; Inflammation; Male; Me | 2019 |
16 other studies available for melatonin and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Sex-related Changes in Circadian Rhythm of Inflammatory and Oxidative Stress Markers in CKD.
Topics: Animals; Antioxidants; Circadian Rhythm; Female; Humans; Male; Melatonin; Oxidative Stress; Rats; Re | 2021 |
Melatonin-stimulated exosomes enhance the regenerative potential of chronic kidney disease-derived mesenchymal stem/stromal cells via cellular prion proteins.
Topics: Animals; Exosomes; Female; Humans; Male; Melatonin; Mesenchymal Stem Cell Transplantation; Mesenchym | 2020 |
THE EFFECTIVENESS OF MELATONIN IN THE COMPLEX TREATMENT OF HYPERTENSION IN PATIENTS WITH STAGE 5 CHRONIC KIDNEY DISEASE.
Topics: Antihypertensive Agents; Antioxidants; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Centra | 2020 |
Melatonin Suppresses Renal Cortical Fibrosis by Inhibiting Cytoskeleton Reorganization and Mitochondrial Dysfunction through Regulation of miR-4516.
Topics: Animals; Cell Line; Cytoskeleton; Fibrosis; Gene Expression Regulation; Kidney Cortex; Male; Melaton | 2020 |
Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis.
Topics: Animals; Cell Line; Disease Models, Animal; Fibrosis; Humans; Kidney; Kidney Function Tests; Male; M | 2021 |
Melatonin ameliorates intrarenal renin-angiotensin system in a 5/6 nephrectomy rat model.
Topics: Actins; Animals; Antioxidants; Collagen Type I; Disease Models, Animal; Drug Evaluation, Preclinical | 2018 |
Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antioxidants; Cell Line; Female; Glomerular Fil | 2018 |
Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrP
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Cellular Senescence; Humans; Immunohist | 2019 |
Melatonin preconditioning of bone marrow-derived mesenchymal stem cells promotes their engraftment and improves renal regeneration in a rat model of chronic kidney disease.
Topics: Animals; Graft Survival; Kidney; Male; Melatonin; Mesenchymal Stem Cell Transplantation; Mesenchymal | 2019 |
Salt Loading Aggravates the Relationship between Melatonin and Proteinuria in Patients with Chronic Kidney Disease.
Topics: Adult; Aged; Albuminuria; Blood Pressure; Body Mass Index; Circadian Rhythm; Female; Humans; Kidney; | 2019 |
Circadian Rhythm and CKD: Is Melatonin a Key Player or Bi-player?
Topics: Circadian Rhythm; Humans; Melatonin; Proteinuria; Renal Insufficiency, Chronic; Sleep | 2019 |
Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis.
Topics: Acute Kidney Injury; Animals; Antioxidants; Biomarkers; Gene Expression Regulation; Intercellular Si | 2019 |
Melatonin in chronic kidney disease: a promising chronotherapy targeting the intrarenal renin-angiotensin system.
Topics: Animals; Antioxidants; Chronotherapy; Humans; Kidney; Melatonin; Renal Insufficiency, Chronic; Renin | 2019 |
Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxid | 2013 |
Melatonin and the Charlson Comorbidity Index (CCI): the Treviso Longeva (Trelong) study.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Cohort Studies; Comorbidity; E | 2014 |
Impaired endogenous nighttime melatonin secretion relates to intrarenal renin-angiotensin system activation and renal damage in patients with chronic kidney disease.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Circadian Rhythm; Female; Humans; Kidney; Male; Mela | 2016 |