Page last updated: 2024-10-19

melatonin and Pulmonary Hypertension

melatonin has been researched along with Pulmonary Hypertension in 13 studies

Research Excerpts

ExcerptRelevanceReference
"Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung."5.46Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017)
"Melatonin is a powerful antioxidant and is cardioprotective against ischemia-reperfusion injury and hypertension."5.42Melatonin as a preventive and curative therapy against pulmonary hypertension. ( Blackhurst, D; Blauwet, L; Butrous, G; Davies, N; Lecour, S; Maarman, G; Sliwa, K; Thienemann, F, 2015)
"Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)."5.35Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008)
"To determine the effect of melatonin at the transcript level of prostanoid pathways in the lung of neonatal lambs gestated and born under hypobaric hypoxia."3.91[Melatonin modulates the expression of pulmonary prostanoids]. ( Aguilar, SA; Arias, PV; Canquil, I; Ebensperger, G; González-Candia, A; Herrera, EA; Llanos, AJ; Reyes, RV, 2019)
"Melatonin is a neurohormone with antioxidant and vasodilator properties at the pulmonary level."1.56Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates. ( Aguilar, SA; Candia, AA; Ebensperger, G; Feixes, E; Figueroa, EG; Gonzaléz-Candia, A; Gonzalez-Candia, C; Herrera, EA; Llanos, AJ; Reyes, RV, 2020)
"Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung."1.46Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017)
" This was associated with an enhanced nitric oxide-dependent and nitric oxide independent vasodilator components and with increased nitric oxide bioavailability in lung tissue."1.42Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep. ( Chubretovic, M; Ebensperger, G; González-Candia, A; Herrera, EA; Llanos, AJ; Montt, C; Reyes, RV; Serón-Ferré, M; Torres, F, 2015)
"Melatonin is a powerful antioxidant and is cardioprotective against ischemia-reperfusion injury and hypertension."1.42Melatonin as a preventive and curative therapy against pulmonary hypertension. ( Blackhurst, D; Blauwet, L; Butrous, G; Davies, N; Lecour, S; Maarman, G; Sliwa, K; Thienemann, F, 2015)
"Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)."1.35Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's7 (53.85)24.3611
2020's4 (30.77)2.80

Authors

AuthorsStudies
Chen, S1
Sun, P1
Li, Y1
Shen, W1
Wang, C1
Zhao, P1
Cui, H1
Xue, JY1
Du, GQ1
Gonzaléz-Candia, A5
Candia, AA1
Figueroa, EG1
Feixes, E1
Gonzalez-Candia, C1
Aguilar, SA2
Ebensperger, G4
Reyes, RV4
Llanos, AJ4
Herrera, EA5
MacLean, MR1
Rivera, E1
García-Herrera, C1
Celentano, DJ1
Hung, MW1
Yeung, HM1
Lau, CF1
Poon, AMS1
Tipoe, GL1
Fung, ML1
Maarman, GJ1
Veliz, M1
Carrasco-Pozo, C1
Castillo, RL1
Cárdenas, JC1
Arias, PV1
Canquil, I1
Jin, H1
Wang, Y1
Zhou, L1
Liu, L1
Zhang, P1
Deng, W1
Yuan, Y1
Torres, F1
Montt, C1
Chubretovic, M1
Serón-Ferré, M1
Maarman, G1
Blackhurst, D1
Thienemann, F1
Blauwet, L1
Butrous, G1
Davies, N1
Sliwa, K1
Lecour, S1
Das, R1
Balonan, L1
Ballard, HJ1
Ho, S1
Backon, J1

Reviews

1 review available for melatonin and Pulmonary Hypertension

ArticleYear
Natural Antioxidants as Potential Therapy, and a Promising Role for Melatonin Against Pulmonary Hypertension.
    Advances in experimental medicine and biology, 2017, Volume: 967

    Topics: Animals; Antioxidants; Biological Products; Humans; Hypertension, Pulmonary; Lung; Melatonin; Phytot

2017

Other Studies

12 other studies available for melatonin and Pulmonary Hypertension

ArticleYear
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
    European journal of pharmacology, 2022, Oct-15, Volume: 933

    Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulm

2022
Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates.
    Journal of pineal research, 2020, Volume: 68, Issue:1

    Topics: Animals; Animals, Newborn; Antioxidants; Arterial Pressure; Hypertension, Pulmonary; Hypoxia; Lung;

2020
Melatonin: shining some light on pulmonary hypertension.
    Cardiovascular research, 2020, 11-01, Volume: 116, Issue:13

    Topics: Endothelium; Humans; Hypertension; Hypertension, Pulmonary; Inflammasomes; Macrophages; Melatonin; P

2020
Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs.
    Journal of the mechanical behavior of biomedical materials, 2020, Volume: 112

    Topics: Animals; Animals, Newborn; Hypertension, Pulmonary; Hypoxia; Melatonin; Pulmonary Artery; Sheep

2020
Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats.
    International journal of molecular sciences, 2017, May-24, Volume: 18, Issue:6

    Topics: Animals; Antioxidants; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Inflammation; Lung; Melato

2017
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.
    Redox biology, 2019, Volume: 22

    Topics: Animals; Animals, Newborn; Antioxidants; Biomarkers; Birth Weight; Blood Gas Analysis; Female; Gene

2019
[Melatonin modulates the expression of pulmonary prostanoids].
    Revista medica de Chile, 2019, Volume: 147, Issue:3

    Topics: Animals; Animals, Newborn; Antioxidants; Hypertension, Pulmonary; Hypoxia; Melatonin; Oxidative Stre

2019
Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells.
    Journal of pineal research, 2014, Volume: 57, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Cell Proliferation; Hypertension

2014
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep.
    Journal of pineal research, 2015, Volume: 58, Issue:3

    Topics: Animals; Animals, Newborn; Antioxidants; Hypertension, Pulmonary; Lung; Melatonin; Oxidative Stress;

2015
Melatonin as a preventive and curative therapy against pulmonary hypertension.
    Journal of pineal research, 2015, Volume: 59, Issue:3

    Topics: Animals; Antioxidants; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Melatonin; Mon

2015
Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery.
    International journal of cardiology, 2008, Jun-06, Volume: 126, Issue:3

    Topics: Animals; Chronic Disease; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Melatonin;

2008
Increased serum copper in pulmonary hypertension: involvement of thromboxane?
    Respiration; international review of thoracic diseases, 1986, Volume: 50, Issue:1

    Topics: Copper; Humans; Hypertension, Pulmonary; Melatonin; Thromboxane A2

1986