melatonin has been researched along with Pulmonary Fibrosis in 11 studies
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals." | 7.80 | Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice. ( Cao, LF; Chen, YH; Liu, RR; Liu, RY; Qing, HY; Wang, H; Wu, QQ; Xu, DX; Zhang, C; Zhao, H, 2014) |
| "Fibrosis is a common occurrence following organ injury and failure." | 6.53 | Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016) |
| "Twenty-five days after BLM treatment, pulmonary fibrosis was assessed as hydroxyproline content in lung homogenates." | 5.31 | The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. ( Arslan, SO; Coskun, A; Vural, H; Zerin, M, 2002) |
| "Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals." | 3.80 | Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice. ( Cao, LF; Chen, YH; Liu, RR; Liu, RY; Qing, HY; Wang, H; Wu, QQ; Xu, DX; Zhang, C; Zhao, H, 2014) |
| "Fibrosis is a common occurrence following organ injury and failure." | 2.53 | Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016) |
| "Treatment with melatonin upregulated Nrf2 expression, inhibited LPS-induced cell morphological change, reversed the expressions of EMT-related proteins, and reduced reactive oxygen species (ROS) production in A549 cells, as well as the levels of malondialdehyde (MDA) and anti-oxidative enzymes." | 1.56 | Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway. ( Ding, Z; Fei, G; Ji, S; Kang, J; Li, J; Wang, Y; Wu, X; Zhang, W, 2020) |
| "Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring." | 1.51 | Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction. ( Fang, R; Guo, Y; Jin, T; Li, F; Li, Y; Liang, H; Shan, H; Su, X; Wang, Y; Yang, R; Zhang, L; Zhao, X, 2019) |
| "Melatonin has direct and indirect free radical-detoxifying activity." | 1.33 | Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats. ( Erdogan, H; Fadillioglu, E; Iraz, M; Kotuk, M; Kuku, I; Yagmurca, M; Yildirim, Z, 2006) |
| "Twenty-five days after BLM treatment, pulmonary fibrosis was assessed as hydroxyproline content in lung homogenates." | 1.31 | The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. ( Arslan, SO; Coskun, A; Vural, H; Zerin, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Lan, YJ | 1 |
| Cheng, MH | 1 |
| Ji, HM | 1 |
| Bi, YQ | 1 |
| Han, YY | 1 |
| Yang, CY | 1 |
| Gu, X | 1 |
| Gao, J | 1 |
| Dong, HL | 1 |
| Aydin, P | 1 |
| Aksakalli-Magden, ZB | 1 |
| Civelek, MS | 1 |
| Karabulut-Uzuncakmak, S | 1 |
| Mokhtare, B | 1 |
| Ozkaraca, M | 1 |
| Alper, F | 1 |
| Halici, Z | 1 |
| Ding, Z | 1 |
| Wu, X | 1 |
| Wang, Y | 2 |
| Ji, S | 1 |
| Zhang, W | 1 |
| Kang, J | 1 |
| Li, J | 1 |
| Fei, G | 1 |
| Sheikholeslami, S | 1 |
| Aryafar, T | 1 |
| Abedi-Firouzjah, R | 1 |
| Banaei, A | 1 |
| Dorri-Giv, M | 1 |
| Zamani, H | 1 |
| Ataei, G | 1 |
| Majdaeen, M | 1 |
| Farhood, B | 1 |
| Zhang, L | 1 |
| Li, F | 1 |
| Su, X | 1 |
| Li, Y | 1 |
| Fang, R | 1 |
| Guo, Y | 1 |
| Jin, T | 1 |
| Shan, H | 2 |
| Zhao, X | 1 |
| Yang, R | 1 |
| Liang, H | 1 |
| Taslidere, E | 1 |
| Esrefoglu, M | 1 |
| Elbe, H | 1 |
| Cetin, A | 1 |
| Ates, B | 1 |
| Zhao, H | 1 |
| Wu, QQ | 1 |
| Cao, LF | 1 |
| Qing, HY | 1 |
| Zhang, C | 1 |
| Chen, YH | 1 |
| Wang, H | 1 |
| Liu, RY | 1 |
| Liu, RR | 1 |
| Xu, DX | 1 |
| Hu, W | 1 |
| Ma, Z | 1 |
| Jiang, S | 1 |
| Fan, C | 1 |
| Deng, C | 1 |
| Yan, X | 1 |
| Di, S | 1 |
| Lv, J | 1 |
| Reiter, RJ | 1 |
| Yang, Y | 1 |
| Genovese, T | 1 |
| Di Paola, R | 1 |
| Mazzon, E | 1 |
| Muià, C | 1 |
| Caputi, AP | 1 |
| Cuzzocrea, S | 1 |
| Yildirim, Z | 1 |
| Kotuk, M | 1 |
| Erdogan, H | 1 |
| Iraz, M | 1 |
| Yagmurca, M | 1 |
| Kuku, I | 1 |
| Fadillioglu, E | 1 |
| Arslan, SO | 1 |
| Zerin, M | 1 |
| Vural, H | 1 |
| Coskun, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19).[NCT04632732] | 140 participants (Actual) | Observational [Patient Registry] | 2020-10-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and Pulmonary Fibrosis
| Article | Year |
|---|---|
The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review.
Topics: Animals; Humans; Lung; Lung Neoplasms; Melatonin; Pneumonia; Pulmonary Fibrosis; Radiation Injuries; | 2021 |
Melatonin: the dawning of a treatment for fibrosis?
Topics: Animals; Extracellular Matrix; Fibrosis; Heart Diseases; Humans; Kidney Diseases; Liver Cirrhosis; M | 2016 |
9 other studies available for melatonin and Pulmonary Fibrosis
| Article | Year |
|---|---|
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression.
Topics: Animals; Bleomycin; Fibroblasts; Galectin 3; Humans; Lung; Melatonin; Mice; NF-E2-Related Factor 2; | 2023 |
The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF-Β1/HMGB1 signaling pathway.
Topics: Animals; Bleomycin; HMGB1 Protein; Lung; Melatonin; NLR Family, Pyrin Domain-Containing 3 Protein; P | 2023 |
Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3β/Nrf2 pathway.
Topics: A549 Cells; Acute Lung Injury; Alveolar Epithelial Cells; Antioxidants; Epithelial-Mesenchymal Trans | 2020 |
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Topics: Animals; Apelin; Apoptosis; Bleomycin; Cell Line, Tumor; Cellular Senescence; Epithelial Cells; Lung | 2019 |
Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Fe | 2014 |
Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice.
Topics: Animals; Antineoplastic Agents; Bleomycin; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulu | 2014 |
Melatonin limits lung injury in bleomycin treated mice.
Topics: Animals; Bleomycin; Immunohistochemistry; Lung; Male; Melatonin; Mice; Poly Adenosine Diphosphate Ri | 2005 |
Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats.
Topics: Animals; Antioxidants; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydroxyproli | 2006 |
The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Bleomycin; Female; Lipid Peroxidation; Lung; Mel | 2002 |