melatonin has been researched along with Pulmonary Edema in 9 studies
Pulmonary Edema: Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats." | 8.31 | Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea. ( Al Gburi, MRA; Altinoz, E; Demir, M; Elbe, H; Karayakali, M; Onal, MO; Yilmaz, N; Yilmaz, U, 2023) |
| "Melatonin decreases pulmonary edema and improves oxygenation after reexpansion by attenuating oxidative stress and inhibiting pro-inflammatory cytokines." | 7.79 | Protective effect of melatonin on reexpansion pulmonary edema in rats model. ( Cang, J; Huang, JF; Wu, W; Xue, ZG; Zhong, M; Zhu, DM, 2013) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 7.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| " As an antioxidant, melatonin administration might be helpful in decreasing post-operative morbidity by decreasing reperfusion injury of lungs." | 7.71 | Effects of melatonin on noncardiogenic pulmonary edema secondary to adnexial ischemia-reperfusion in guinea pig. ( Ayar, A; Bildirici, I; Celik, H; Cikim, G; Ozercan, I; Simsek, M; Tug, N, 2002) |
| "Melatonin is a strong antioxidant that has beneficial effects against SAH in rats, including reduced mortality and reduced neurological deficits." | 5.42 | Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats. ( Cao, S; Chen, G; Chen, J; Duan, H; Gu, C; Li, J; Qian, C; Wang, L; Yan, F; Yu, X, 2015) |
| "We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats." | 4.31 | Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea. ( Al Gburi, MRA; Altinoz, E; Demir, M; Elbe, H; Karayakali, M; Onal, MO; Yilmaz, N; Yilmaz, U, 2023) |
| "Melatonin decreases pulmonary edema and improves oxygenation after reexpansion by attenuating oxidative stress and inhibiting pro-inflammatory cytokines." | 3.79 | Protective effect of melatonin on reexpansion pulmonary edema in rats model. ( Cang, J; Huang, JF; Wu, W; Xue, ZG; Zhong, M; Zhu, DM, 2013) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 3.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| " As an antioxidant, melatonin administration might be helpful in decreasing post-operative morbidity by decreasing reperfusion injury of lungs." | 3.71 | Effects of melatonin on noncardiogenic pulmonary edema secondary to adnexial ischemia-reperfusion in guinea pig. ( Ayar, A; Bildirici, I; Celik, H; Cikim, G; Ozercan, I; Simsek, M; Tug, N, 2002) |
| "Melatonin is a potent antioxidant and in many studies melatonin has been shown to be more effective than some "classical" antioxidants (e." | 2.45 | Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin? ( Gögenur, I; Kücükakin, B; Reiter, RJ; Rosenberg, J, 2009) |
| "Melatonin is a strong antioxidant that has beneficial effects against SAH in rats, including reduced mortality and reduced neurological deficits." | 1.42 | Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats. ( Cao, S; Chen, G; Chen, J; Duan, H; Gu, C; Li, J; Qian, C; Wang, L; Yan, F; Yu, X, 2015) |
| "Melatonin pretreatment prior to liver I/R can effectively reduce the pulmonary microvascular permeability and attenuate lipid peroxidation in the lungs." | 1.38 | Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats. ( Chen, CF; Chen, KH; Chiu, MH; Su, CL; Wang, D; Wang, JJ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Al Gburi, MRA | 1 |
| Altinoz, E | 1 |
| Elbe, H | 2 |
| Onal, MO | 1 |
| Yilmaz, U | 1 |
| Yilmaz, N | 1 |
| Karayakali, M | 1 |
| Demir, M | 1 |
| Zhong, M | 1 |
| Xue, ZG | 1 |
| Cang, J | 1 |
| Wu, W | 1 |
| Huang, JF | 1 |
| Zhu, DM | 1 |
| Taslidere, E | 1 |
| Esrefoglu, M | 1 |
| Cetin, A | 1 |
| Ates, B | 1 |
| Chen, J | 1 |
| Qian, C | 1 |
| Duan, H | 1 |
| Cao, S | 1 |
| Yu, X | 1 |
| Li, J | 1 |
| Gu, C | 1 |
| Yan, F | 1 |
| Wang, L | 1 |
| Chen, G | 1 |
| Santana-Rodríguez, N | 1 |
| Clavo, B | 1 |
| Llontop, P | 1 |
| López, A | 1 |
| García-Castellano, JM | 1 |
| Machín, RP | 1 |
| Ponce, MA | 1 |
| Fiuza, MD | 1 |
| García-Herrera, R | 1 |
| Brito, Y | 1 |
| Yordi, NA | 1 |
| Chirino, R | 1 |
| Chiu, MH | 1 |
| Su, CL | 1 |
| Chen, CF | 1 |
| Chen, KH | 1 |
| Wang, D | 1 |
| Wang, JJ | 1 |
| Wu, WS | 1 |
| Chou, MT | 1 |
| Chao, CM | 1 |
| Chang, CK | 1 |
| Lin, MT | 1 |
| Chang, CP | 1 |
| Kücükakin, B | 1 |
| Gögenur, I | 1 |
| Reiter, RJ | 1 |
| Rosenberg, J | 1 |
| Celik, H | 1 |
| Ayar, A | 1 |
| Tug, N | 1 |
| Simsek, M | 1 |
| Ozercan, I | 1 |
| Cikim, G | 1 |
| Bildirici, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| The Problem of Insulin Resistance in Patients After Carotid Revascularization[NCT03419767] | Phase 4 | 60 participants (Anticipated) | Interventional | 2017-08-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for melatonin and Pulmonary Edema
| Article | Year |
|---|---|
Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?
Topics: Antioxidants; Circadian Rhythm; Humans; Melatonin; Oxidative Stress; Pulmonary Edema; Surgical Proce | 2009 |
8 other studies available for melatonin and Pulmonary Edema
| Article | Year |
|---|---|
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea.
Topics: Animals; Melatonin; Pinealectomy; Pulmonary Edema; Rats; Thiourea; Tumor Necrosis Factor-alpha | 2023 |
Protective effect of melatonin on reexpansion pulmonary edema in rats model.
Topics: Animals; Cytokines; Interleukin-8; Lung; Male; Malondialdehyde; Melatonin; Nitric Oxide; Oxidative S | 2013 |
Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Fe | 2014 |
Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats.
Topics: Animals; Antioxidants; Apoptosis; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 9; Melat | 2015 |
Estradiol worsens the syndrome of ischemia-reperfusion injury in an experimental lung transplantation model.
Topics: Animals; Antioxidants; Chi-Square Distribution; Deferoxamine; Disease Models, Animal; Estradiol; Gra | 2011 |
Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Capillary Permeability; Cytoprotection; Disease Models, An | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Effects of melatonin on noncardiogenic pulmonary edema secondary to adnexial ischemia-reperfusion in guinea pig.
Topics: Adnexal Diseases; Animals; Antioxidants; Female; Guinea Pigs; Lung; Malondialdehyde; Melatonin; Ovar | 2002 |