Page last updated: 2024-10-19

melatonin and Psychoses

melatonin has been researched along with Psychoses in 18 studies

Research Excerpts

ExcerptRelevanceReference
"The results from this trial will examine whether melatonin has a role in withdrawing long-term benzodiazepine administration in schizophrenia patients."9.15Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol. ( Baandrup, L; Fagerlund, B; Glenthoj, BY; Gluud, C; Hansen, JL; Jennum, P; Lublin, H; Oranje, B; Winkel, P, 2011)
" Since depression is associated with diminished melatonin secretion, the high incidence of TD in patients with history of depression may be linked to diminished secretory activity of the pineal melatonin."7.68Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin. ( Pardeshi, R; Sandyk, R, 1990)
" Reduced benzodiazepine dosage at the 24-week follow-up was associated with a significantly decreased proportion of stage 2 sleep."6.82Objective and subjective sleep quality: Melatonin versus placebo add-on treatment in patients with schizophrenia or bipolar disorder withdrawing from long-term benzodiazepine use. ( Baandrup, L; Glenthøj, BY; Jennum, PJ, 2016)
"The results from this trial will examine whether melatonin has a role in withdrawing long-term benzodiazepine administration in schizophrenia patients."5.15Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol. ( Baandrup, L; Fagerlund, B; Glenthoj, BY; Gluud, C; Hansen, JL; Jennum, P; Lublin, H; Oranje, B; Winkel, P, 2011)
" Since depression is associated with diminished melatonin secretion, the high incidence of TD in patients with history of depression may be linked to diminished secretory activity of the pineal melatonin."3.68Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin. ( Pardeshi, R; Sandyk, R, 1990)
" Reduced benzodiazepine dosage at the 24-week follow-up was associated with a significantly decreased proportion of stage 2 sleep."2.82Objective and subjective sleep quality: Melatonin versus placebo add-on treatment in patients with schizophrenia or bipolar disorder withdrawing from long-term benzodiazepine use. ( Baandrup, L; Glenthøj, BY; Jennum, PJ, 2016)
"Distinguishing circadian timing from other sleep phenotypes will allow adaptation for dosage of time-directed intervention, useful in stabilizing circadian timekeeping physiology and potentially reducing the multisystemic disruption in mental health disorders."1.91Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis. ( Alexander, I; Cosgrave, J; Foster, RG; Middleton, B; Porcheret, K; Purple, RJ; Wulff, K, 2023)
"In melatonin treated rats, prefrontal tissue malondialdehyde and protein carbonyl levels were decreased significantly in comparison with MK-801 group (p < 0."1.40Potential role of some oxidant/antioxidant status parameters in prefrontal cortex of rat brain in an experimental psychosis model and the protective effects of melatonin. ( Akyol, O; Kus, I; Ozyurt, B; Ozyurt, H; Sarsilmaz, M; Songur, A, 2014)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19904 (22.22)18.7374
1990's4 (22.22)18.2507
2000's2 (11.11)29.6817
2010's6 (33.33)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Purple, RJ2
Cosgrave, J2
Alexander, I2
Middleton, B2
Foster, RG2
Porcheret, K2
Wulff, K2
Nordholm, D1
Jensen, MA1
Glenthøj, LB1
Kristensen, TD1
Wenneberg, C1
Garde, AH1
Nordentoft, M1
Ozyurt, H1
Ozyurt, B1
Sarsilmaz, M1
Kus, I1
Songur, A1
Akyol, O1
Inanir, S1
Copoglu, US1
Kokacya, H1
Dokuyucu, R1
Erbas, O1
Inanir, A1
Baandrup, L2
Glenthøj, BY1
Jennum, PJ1
Lamont, EW1
Coutu, DL1
Cermakian, N1
Boivin, DB1
Kolesnikov, DB1
Rapoport, SI1
Voznesenskaia, LA1
Fagerlund, B1
Jennum, P1
Lublin, H1
Hansen, JL1
Winkel, P1
Gluud, C1
Oranje, B1
Glenthoj, BY1
Miyazaki, T1
Kuwano, H1
Kato, H1
Ando, H1
Kimura, H1
Inose, T1
Ohno, T1
Suzuki, M1
Nakajima, M1
Manda, R1
Fukuchi, M1
Tsukada, K1
Tharandt, L1
Reinwein, D1
Wahlund, B1
Sääf, J1
Grahn, H1
Wetterberg, L1
Katz, G2
Durst, R3
Barel, YC1
Knobler, HY2
Campbell, KM1
Wade, D1
Ross, LW1
Meyer, GG1
Mullen, PE1
Silman, RE1
Robinson, S1
Rosca, P1
Shai, U1
Ghinea, C1
Schmidt, U1
Nir, I1
Sandyk, R1
Pardeshi, R1
Johnston, VS1
Bradley, RJ1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia[NCT03075657]Phase 4120 participants (Actual)Interventional2017-05-01Completed
Prolonged-release Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia: a Randomized Clinical Trial[NCT01431092]Phase 486 participants (Actual)Interventional2011-10-31Completed
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172]Phase 260 participants (Actual)Interventional2014-12-31Completed
Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504]Phase 425 participants (Actual)Interventional2008-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Abdominal Fat (DEXA).

A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Interventiong (Mean)
Ramelteon3934.86
Placebo (Sugar Pill)5120.92

Change in Insulin Resistance as Measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

InterventionHOMA score (Mean)
Ramelteon2.4
Placebo (Sugar Pill)2.36

Change in Waist Circumference

A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Interventioncm (Mean)
Ramelteon106.09
Placebo (Sugar Pill)108.37

Reviews

4 reviews available for melatonin and Psychoses

ArticleYear
Circadian rhythms and clock genes in psychotic disorders.
    The Israel journal of psychiatry and related sciences, 2010, Volume: 47, Issue:1

    Topics: Animals; Bipolar Disorder; Circadian Rhythm; CLOCK Proteins; Glycogen Synthase Kinase 3; Humans; Lit

2010
[Psychic disorders and gastrointestinal pathology. Part 2].
    Klinicheskaia meditsina, 2010, Volume: 88, Issue:6

    Topics: Gastrointestinal Diseases; Humans; Melatonin; Psychotic Disorders; Risk Factors

2010
[Melatonin, a clinically important hormone?].
    Deutsche medizinische Wochenschrift (1946), 1983, Mar-25, Volume: 108, Issue:12

    Topics: Animals; Brain Neoplasms; Breast Neoplasms; Central Nervous System; Circadian Rhythm; Female; Humans

1983
Molecular pharmacology of hallucinogens.
    Recent advances in biological psychiatry, 1968, Volume: 10

    Topics: Amphetamine; Animals; Avoidance Learning; Brain; Conditioning, Operant; Emotions; Hallucinogens; Hum

1968

Trials

2 trials available for melatonin and Psychoses

ArticleYear
Objective and subjective sleep quality: Melatonin versus placebo add-on treatment in patients with schizophrenia or bipolar disorder withdrawing from long-term benzodiazepine use.
    Psychiatry research, 2016, 06-30, Volume: 240

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Central Nervous System Depressants;

2016
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
    BMC psychiatry, 2011, Oct-05, Volume: 11

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara

2011
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
    BMC psychiatry, 2011, Oct-05, Volume: 11

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara

2011
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
    BMC psychiatry, 2011, Oct-05, Volume: 11

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara

2011
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol.
    BMC psychiatry, 2011, Oct-05, Volume: 11

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Clinical Protocols; Delayed-Action Prepara

2011

Other Studies

12 other studies available for melatonin and Psychoses

ArticleYear
Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis.
    Sleep, 2023, 03-09, Volume: 46, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Phenotype; Psychotic Disorders; Sleep

2023
Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis.
    Sleep, 2023, 03-09, Volume: 46, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Phenotype; Psychotic Disorders; Sleep

2023
Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis.
    Sleep, 2023, 03-09, Volume: 46, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Phenotype; Psychotic Disorders; Sleep

2023
Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis.
    Sleep, 2023, 03-09, Volume: 46, Issue:3

    Topics: Circadian Rhythm; Humans; Melatonin; Phenotype; Psychotic Disorders; Sleep

2023
Sleep disturbances and the association with attenuated psychotic symptoms in individuals at ultra high-risk of psychosis.
    Journal of psychiatric research, 2023, Volume: 158

    Topics: Adolescent; Adult; Humans; Melatonin; Psychiatric Status Rating Scales; Psychotic Disorders; Risk Fa

2023
Potential role of some oxidant/antioxidant status parameters in prefrontal cortex of rat brain in an experimental psychosis model and the protective effects of melatonin.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:15

    Topics: Animals; Antioxidants; Disease Models, Animal; Dizocilpine Maleate; Glutathione Peroxidase; Male; Ma

2014
Agomelatine Protection in an LPS-Induced Psychosis-Relevant Behavior Model.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, Dec-08, Volume: 21

    Topics: Acetamides; Animals; Brain; Lipopolysaccharides; Male; Malondialdehyde; Melatonin; Psychotic Disorde

2015
Correlation between serum melatonin circadian rhythm and intensive care unit psychosis after thoracic esophagectomy.
    Surgery, 2003, Volume: 133, Issue:6

    Topics: Adult; Aged; Circadian Rhythm; Esophageal Neoplasms; Esophagectomy; Female; Humans; Intensive Care U

2003
Diagnostic subgrouping of depressed patients by principal component analysis and visualized pattern recognition.
    Psychiatry research, 1998, Dec-14, Volume: 81, Issue:3

    Topics: Adult; Biomarkers; Bipolar Disorder; Blood Platelets; Depressive Disorder; Dexamethasone; Female; Fo

1998
De novo jet-lag psychosis.
    The British journal of psychiatry : the journal of mental science, 1999, Volume: 174

    Topics: Adult; Anti-Anxiety Agents; Antipsychotic Agents; Clopenthixol; Female; Humans; Jet Lag Syndrome; Ma

1999
Exogenous melatonin, jet lag, and psychosis: preliminary case results.
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:3

    Topics: Adult; Antioxidants; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged; Psychotic Disor

2001
Pigmentation and musculoskeletal abnormalities in an aged state hospital population.
    Journal of the American Geriatrics Society, 1977, Volume: 25, Issue:9

    Topics: Adult; Aged; Bone Diseases; Dihydroxyphenylalanine; Female; Humans; Male; Melanins; Melatonin; Menta

1977
The pineal and psychiatry: a review.
    Psychological medicine, 1977, Volume: 7, Issue:3

    Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Humans; Melatonin; Pineal Gland; Psychotic

1977
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients.
    Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3

    Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu

1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients.
    Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3

    Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu

1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients.
    Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3

    Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu

1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients.
    Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3

    Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu

1991
Mood-dependent fluctuations in the severity of tardive dyskinesia and psoriasis vulgaris in a patient with schizoaffective disorder: possible role of melatonin.
    The International journal of neuroscience, 1990, Volume: 50, Issue:3-4

    Topics: Adult; Depression; Dyskinesia, Drug-Induced; Female; Humans; Melatonin; Psoriasis; Psychotic Disorde

1990