melatonin has been researched along with Psychomotor Agitation in 14 studies
Psychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia." | 9.09 | Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study. ( Cats, Q; Haffmans, PM; Lucius, SA; Sival, RC; van Gelder, L, 2001) |
| " All papers on melatonin treatment in dementia were retrieved." | 8.86 | Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010) |
| "Patients with Alzheimer dementia often display both agitated behavior and poor sleep." | 6.74 | Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. ( Ancoli-Israel, S; Connor, DJ; Corey-Bloom, J; Gehrman, PR; Martin, JL; Shochat, T, 2009) |
| "Melatonin was not only as effective as midazolam in alleviating preoperative anxiety in children, but it was also associated with a tendency towards faster recovery, lower incidence of excitement postoperatively and a lower incidence of sleep disturbance at week 2 postoperatively." | 5.11 | Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. ( Albassam, A; Aldammas, F; Alotibi, W; Naguib, M; Riad, W; Samarkandi, A; Thalaj, A, 2005) |
| "The purpose of this study was to evaluate the effects of bright light therapy combined with melatonin on motor restless behaviour in dementia." | 5.09 | Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study. ( Cats, Q; Haffmans, PM; Lucius, SA; Sival, RC; van Gelder, L, 2001) |
| " All papers on melatonin treatment in dementia were retrieved." | 4.86 | Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. ( de Jonghe, A; de Rooij, SE; Korevaar, JC; van Munster, BC, 2010) |
| "Patients with Alzheimer dementia often display both agitated behavior and poor sleep." | 2.74 | Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. ( Ancoli-Israel, S; Connor, DJ; Corey-Bloom, J; Gehrman, PR; Martin, JL; Shochat, T, 2009) |
| "Delirium is a common syndrome among hospitalized elderly patients." | 1.32 | The relation between the clinical subtypes of delirium and the urinary level of 6-SMT. ( Balan, S; Blagman, B; Chana, W; Habot, B; Leibovitz, A; Neumann, E; Rahel, B; Richard, G; Ruth, M; Yassica, B; Zila, SO, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Provini, F | 1 |
| Mihara, T | 1 |
| Nakamura, N | 1 |
| Ka, K | 1 |
| Oba, MS | 1 |
| Goto, T | 1 |
| Messerschmidt, K | 1 |
| Gehrman, PR | 1 |
| Connor, DJ | 1 |
| Martin, JL | 1 |
| Shochat, T | 1 |
| Corey-Bloom, J | 1 |
| Ancoli-Israel, S | 1 |
| de Jonghe, A | 1 |
| Korevaar, JC | 1 |
| van Munster, BC | 1 |
| de Rooij, SE | 1 |
| Özcengiz, D | 1 |
| Gunes, Y | 1 |
| Ozmete, O | 1 |
| Balan, S | 1 |
| Leibovitz, A | 1 |
| Zila, SO | 1 |
| Ruth, M | 1 |
| Chana, W | 1 |
| Yassica, B | 1 |
| Rahel, B | 1 |
| Richard, G | 1 |
| Neumann, E | 1 |
| Blagman, B | 1 |
| Habot, B | 1 |
| Mahlberg, R | 2 |
| Kunz, D | 1 |
| Sutej, I | 1 |
| Kühl, KP | 1 |
| Hellweg, R | 1 |
| Samarkandi, A | 1 |
| Naguib, M | 1 |
| Riad, W | 1 |
| Thalaj, A | 1 |
| Alotibi, W | 1 |
| Aldammas, F | 1 |
| Albassam, A | 1 |
| Eeles, EM | 1 |
| Stephens, M | 1 |
| Benedict, C | 1 |
| Beaverstock, J | 1 |
| Gupta, M | 1 |
| Page, M | 1 |
| Walther, S | 1 |
| Sharer, J | 1 |
| McGaffigan, S | 1 |
| Bliwise, DL | 1 |
| Haffmans, PM | 1 |
| Sival, RC | 1 |
| Lucius, SA | 1 |
| Cats, Q | 1 |
| van Gelder, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172] | Phase 2 | 60 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Prevention of Delirium in Inpatients Utilizing Melatonin[NCT02654314] | Phase 3 | 277 participants (Actual) | Interventional | 2016-07-31 | Terminated (stopped due to Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.) | ||
| Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309] | Phase 3 | 25 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT[NCT04034771] | Phase 3 | 38 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Days utilizing restraints is defined as the number of days restraints were applied because of delirium in the first 14 days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
| Intervention | days (Median) |
|---|---|
| Melatonin | 0 |
| Cellulose Microcrystylline | 0 |
Delirium is defined by the Short Form Confusion Assessment Method (CAM). There must be inattention and either an acute or fluctuating course plus either disorganized thinking or an altered level of consciousness to be diagnosed with delirium. Presented is a count of individuals with reported delirium during hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Melatonin | 2 |
| Cellulose Microcrystylline | 8 |
Length of stay is defined as the total time hospitalized for the acute illness (in days). (NCT02654314)
Timeframe: from day of admission to completion of acute care, not to exceed 30 days
| Intervention | days (Mean) |
|---|---|
| Melatonin | 4.58 |
| Cellulose Microcrystylline | 4.71 |
Number of delirium anti-psychotic drug doses given for symptoms of delirium. Presented are the number of doses per days of hospitalization. (NCT02654314)
Timeframe: length of hospitalization, not to exceed 14 days
| Intervention | number of doses per days of hospitalizat (Median) |
|---|---|
| Melatonin | 0 |
| Cellulose Microcrystylline | 0 |
5 reviews available for melatonin and Psychomotor Agitation
| Article | Year |
|---|---|
Agrypnia excitata.
Topics: Alcohol Withdrawal Delirium; Animals; Atrophy; Autoantibodies; Autoantigens; Disease Models, Animal; | 2013 |
Effects of melatonin premedication to prevent emergence agitation after general anaesthesia in children: A systematic review and meta-analysis with trial sequential analysis.
Topics: Anesthesia Recovery Period; Anesthesia, General; Child; Humans; Melatonin; Premedication; Psychomoto | 2015 |
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F | 2010 |
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F | 2010 |
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F | 2010 |
Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review.
Topics: Aged; Aged, 80 and over; Central Nervous System Depressants; Circadian Rhythm; Delirium; Dementia; F | 2010 |
Tackling sundowning in a patient with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anti-Anxiety Agents; Antipsychotic Agents; Behavior Therapy; Circadian Rhyt | 2008 |
The treatment of sundowning. A selective review of pharmacological and nonpharmacological studies.
Topics: Antipsychotic Agents; Chlormethiazole; Clozapine; Dementia; Humans; Melatonin; Phototherapy; Psychom | 1997 |
5 trials available for melatonin and Psychomotor Agitation
| Article | Year |
|---|---|
Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Central Nervous System Depressants; Circadian Rhythm; Double-Blind Method; | 2009 |
Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children.
Topics: Administration, Oral; Child; Child, Preschool; Dexmedetomidine; Female; Humans; Male; Melatonin; Met | 2011 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Actigraphy in agitated patients with dementia. Monitoring treatment outcomes.
Topics: Aged; Aged, 80 and over; Dementia; Dronabinol; Female; Humans; Male; Melatonin; Middle Aged; Monitor | 2007 |
Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study.
Topics: Aged; Aggression; Anticonvulsants; Combined Modality Therapy; Cross-Over Studies; Dementia; Double-B | 2001 |
4 other studies available for melatonin and Psychomotor Agitation
| Article | Year |
|---|---|
Melatonin Supplementation to Prevent Delirium in Hospitalized Elderly Patients.
Topics: Aged; Central Nervous System Depressants; Delirium; Geriatric Assessment; Hospitalization; Humans; I | 2016 |
The relation between the clinical subtypes of delirium and the urinary level of 6-SMT.
Topics: Aged; Aged, 80 and over; Comorbidity; Delirium; Female; Geriatric Assessment; Humans; International | 2003 |
Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chronobiology Disorders; Female; Humans; Male; Melatonin | 2004 |
Sleep in dementia assessment may require a multidisciplinary approach.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arousal; Combined Modality Therapy; Double-Blind Method; | 2006 |