melatonin has been researched along with Primary Ovarian Insufficiency in 9 studies
Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin (MT) is an endogenous hormone synthesized mainly by pineal cells and has strong endogenous effects in regulating ovarian function." | 2.82 | Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved. ( Guo, YM; He, JL; Qi, MK; Sun, TC; Wang, HB; Wang, HP; Yang, LY, 2022) |
| "Premature ovarian failure is one of the side effects of chemotherapy in pre-menopausal cancer patients." | 2.55 | Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy. ( Choi, Y; Hong, K; Jang, H, 2017) |
| "Melatonin (MT) acts as a protective for the ovary." | 1.72 | Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency. ( Leng, X; Li, Y; Wu, D; Xu, C; Zhao, W; Zhou, X, 2022) |
| "Melatonin treatment delayed granulosa cell aging progression." | 1.56 | The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin. ( Gu, L; He, Q; Li, PA; Lin, Q; Liu, C; Ma, Y; Pei, X; Yang, Y, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 6 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, QY | 1 |
| Chen, SR | 1 |
| Zhao, YX | 1 |
| Chen, JM | 1 |
| Chen, WH | 1 |
| Lin, S | 1 |
| Shi, QY | 1 |
| Feng, J | 1 |
| Ma, WW | 1 |
| Li, HX | 1 |
| Pei, XY | 1 |
| Deng, SL | 1 |
| Jia, H | 1 |
| Ma, WZ | 1 |
| Qi, MK | 1 |
| Sun, TC | 1 |
| Yang, LY | 1 |
| He, JL | 1 |
| Guo, YM | 1 |
| Wang, HB | 1 |
| Wang, HP | 1 |
| Wu, D | 4 |
| Zhao, W | 3 |
| Xu, C | 3 |
| Zhou, X | 3 |
| Leng, X | 3 |
| Li, Y | 4 |
| Liu, Y | 1 |
| Fang, Y | 1 |
| Wei, J | 1 |
| Zhang, C | 1 |
| He, Q | 1 |
| Gu, L | 1 |
| Lin, Q | 1 |
| Ma, Y | 1 |
| Liu, C | 1 |
| Pei, X | 1 |
| Li, PA | 1 |
| Yang, Y | 1 |
| Jang, H | 2 |
| Hong, K | 2 |
| Choi, Y | 2 |
| Na, Y | 1 |
| Lee, S | 1 |
| Moon, S | 1 |
| Cho, M | 1 |
| Park, M | 1 |
| Lee, OH | 1 |
| Chang, EM | 1 |
| Lee, DR | 1 |
| Ko, JJ | 1 |
| Lee, WS | 1 |
| Voznesenskaya, T | 1 |
| Makogon, N | 1 |
| Bryzgina, T | 1 |
| Sukhina, V | 1 |
| Grushka, N | 1 |
| Alexeyeva, I | 1 |
2 reviews available for melatonin and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved.
Topics: China; Female; Hippo Signaling Pathway; Humans; Melatonin; Primary Ovarian Insufficiency; Signal Tra | 2022 |
Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Female | 2017 |
7 other studies available for melatonin and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
Melatonin enhances autologous adipose-derived stem cells to improve mouse ovarian function in relation to the SIRT6/NF-κB pathway.
Topics: Animals; Female; Humans; Melatonin; Mice; NF-kappa B; Primary Ovarian Insufficiency; Sirtuins; Stem | 2022 |
Melatonin prevents cyclophosphamide-induced primordial follicle loss by inhibiting ovarian granulosa cell apoptosis and maintaining AMH expression.
Topics: Animals; Anti-Mullerian Hormone; Apoptosis; Cyclophosphamide; Female; Granulosa Cells; Humans; Melat | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency.
Topics: Autophagy; Female; Granulosa Cells; Humans; Melatonin; Menopause, Premature; MicroRNAs; Phosphatidyl | 2022 |
Melatonin Protects against Primary Ovarian Insufficiency by Activating the PI3K/Akt/mTOR Pathway and Inhibiting Autophagy.
Topics: Apoptosis; Autophagy; Autophagy-Related Proteins; Female; Humans; Melatonin; Phosphatidylinositol 3- | 2022 |
The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
Topics: Animals; Antioxidants; beta Catenin; Cells, Cultured; Cellular Senescence; Endopeptidases; Estrogens | 2020 |
Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27
Topics: Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Cyclin-Dependent Kinase Inhibitor p27; Drug | 2017 |
Melatonin protects against experimental immune ovarian failure in mice.
Topics: Animals; Antibodies, Heterophile; Apoptosis; Female; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inb | 2007 |