Page last updated: 2024-10-19

melatonin and Preterm Birth

melatonin has been researched along with Preterm Birth in 10 studies

Research Excerpts

ExcerptRelevanceReference
"Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury."7.91Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019)
"Placental insufficiency affects about 10% of pregnancies and can lead to pre-eclampsia, fetal growth restriction, and preterm birth."6.82The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review. ( Bussolaro, S; Fantasia, I; Rolnik, DL; Stampalija, T, 2022)
"Intrauterine inflammation is shown to be associated with preterm birth, fetal inflammatory response syndrome, and other pregnancy-related comorbidities such as central nervous system diseases including cerebral palsy and periventricular leukomalacia, pulmonary diseases such as bronchopulmonary dysplasia and respiratory distress syndrome, and necrotizing enterocolitis, to name a few."6.72Melatonin for the prevention of fetal injury associated with intrauterine inflammation. ( Kim, JM; Lee, JY; Lee, SY, 2021)
" Because children with CP from preterm birth also exhibit a sustained immune system hyper-reactivity, we hypothesized that neuro-immunomodulation with a regimen of repurposed endogenous neurorestorative medications, erythropoietin (EPO) and melatonin (MLT), could improve this trajectory."5.51Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury. ( Burkhardt, C; Burton, VJ; Fouda, MA; Gerner, G; Hamimi, S; Jantzie, LL; Kitase, Y; Muthukumar, S; Northington, FJ; Robinson, S; Scafidi, J; Vasan, V; Ye, X, 2022)
"Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury."3.91Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model. ( Burd, I; Dash, O; Hwang, JY; Lee, JY; Lei, J; McLane, MW; Park, M; Shin, NE; Song, H, 2019)
"Melatonin has been shown to have anti-oxidant/anti-inflammatory effects and to reduce brain damage, mainly after hypoxic ischemic encephalopathy."3.01Oral melatonin as a new tool for neuroprotection in preterm newborns: study protocol for a randomized controlled trial. ( Accorsi, P; Angelini, M; Aversa, S; Caporali, C; Cociglio, S; De Silvestri, A; Fazzi, E; Garofoli, F; Longo, S; Orcesi, S; Pisoni, C; Rizzo, V; Tzialla, C; Zecca, M, 2021)
"Placental insufficiency affects about 10% of pregnancies and can lead to pre-eclampsia, fetal growth restriction, and preterm birth."2.82The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review. ( Bussolaro, S; Fantasia, I; Rolnik, DL; Stampalija, T, 2022)
"Intrauterine inflammation is shown to be associated with preterm birth, fetal inflammatory response syndrome, and other pregnancy-related comorbidities such as central nervous system diseases including cerebral palsy and periventricular leukomalacia, pulmonary diseases such as bronchopulmonary dysplasia and respiratory distress syndrome, and necrotizing enterocolitis, to name a few."2.72Melatonin for the prevention of fetal injury associated with intrauterine inflammation. ( Kim, JM; Lee, JY; Lee, SY, 2021)
"Melatonin plays an important role in the sleep-wake cycle."2.53Effects of intrauterine growth restriction on sleep and the cardiovascular system: The use of melatonin as a potential therapy? ( Horne, RS; Miller, SL; Wallace, EM; Yiallourou, SR, 2016)
"Melatonin was analyzed in 392 breast milk samples from 98 healthy nursing mothers at 0 to 30 days postpartum."1.51Variations in melatonin levels in preterm and term human breast milk during the first month after delivery. ( Bei, F; Bu, J; Liu, Y; Qin, Y; Shi, W; Sun, J; Tang, L; Zhuang, J, 2019)
"Preterm birth is a major contributor to early and delayed physical and cognitive impairment."1.46Maternal administration of melatonin exerts short- and long-term neuroprotective effects on the offspring from lipopolysaccharide-treated mice. ( Aisemberg, J; Bariani, MV; Correa, F; Domínguez Rubio, AP; Dorfman, D; Franchi, AM; Rosenstein, RE; Zorrilla Zubilete, M, 2017)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (60.00)24.3611
2020's4 (40.00)2.80

Authors

AuthorsStudies
Jantzie, LL1
Muthukumar, S1
Kitase, Y1
Vasan, V1
Fouda, MA1
Hamimi, S1
Burkhardt, C1
Burton, VJ1
Gerner, G1
Scafidi, J1
Ye, X1
Northington, FJ1
Robinson, S1
Fantasia, I1
Bussolaro, S1
Stampalija, T1
Rolnik, DL1
Qin, Y1
Shi, W1
Zhuang, J1
Liu, Y1
Tang, L1
Bu, J1
Sun, J1
Bei, F1
Garofoli, F1
Longo, S1
Pisoni, C1
Accorsi, P1
Angelini, M1
Aversa, S1
Caporali, C1
Cociglio, S1
De Silvestri, A1
Fazzi, E1
Rizzo, V1
Tzialla, C1
Zecca, M1
Orcesi, S1
Kim, JM1
Lee, SY1
Lee, JY2
Domínguez Rubio, AP1
Correa, F1
Aisemberg, J1
Dorfman, D1
Bariani, MV1
Rosenstein, RE1
Zorrilla Zubilete, M1
Franchi, AM1
Tarocco, A1
Caroccia, N1
Morciano, G1
Wieckowski, MR1
Ancora, G1
Garani, G1
Pinton, P1
Song, H1
Dash, O1
Park, M1
Shin, NE1
McLane, MW1
Lei, J1
Hwang, JY1
Burd, I1
Yiallourou, SR1
Wallace, EM1
Miller, SL1
Horne, RS1
Anderson, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Oral Melatonin as Neuroprotectant in Preterm Infants .A Prospective, Double Blind vs Placebo, Parallel Arms Study[NCT04235673]60 participants (Actual)Interventional2020-05-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for melatonin and Preterm Birth

ArticleYear
The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review.
    European journal of obstetrics, gynecology, and reproductive biology, 2022, Volume: 278

    Topics: Antioxidants; Aspirin; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Melatonin; Placent

2022
Melatonin for the prevention of fetal injury associated with intrauterine inflammation.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2021, Volume: 86, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Brain Injuries; Bronchopulmonary Dysplasia; Female; Fetal Disease

2021
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care.
    Cell death & disease, 2019, 04-08, Volume: 10, Issue:4

    Topics: Autophagy; Blood-Brain Barrier; Cell Death; Female; Free Radical Scavengers; Humans; Infant, Newborn

2019
Effects of intrauterine growth restriction on sleep and the cardiovascular system: The use of melatonin as a potential therapy?
    Sleep medicine reviews, 2016, Volume: 26

    Topics: Antioxidants; Cardiovascular System; Child Development; Fetal Growth Retardation; Humans; Infant; In

2016

Trials

2 trials available for melatonin and Preterm Birth

ArticleYear
Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury.
    Developmental neuroscience, 2022, Volume: 44, Issue:4-5

    Topics: Animals; Brain Injuries; Erythropoietin; Female; Gait; Humans; Infant; Melatonin; Pregnancy; Prematu

2022
Oral melatonin as a new tool for neuroprotection in preterm newborns: study protocol for a randomized controlled trial.
    Trials, 2021, Jan-22, Volume: 22, Issue:1

    Topics: Female; Humans; Infant; Infant, Newborn; Infant, Premature; Melatonin; Multicenter Studies as Topic;

2021

Other Studies

4 other studies available for melatonin and Preterm Birth

ArticleYear
Variations in melatonin levels in preterm and term human breast milk during the first month after delivery.
    Scientific reports, 2019, 11-29, Volume: 9, Issue:1

    Topics: Adult; Biological Variation, Individual; Breast Feeding; Circadian Rhythm; Female; Humans; Infant Nu

2019
Maternal administration of melatonin exerts short- and long-term neuroprotective effects on the offspring from lipopolysaccharide-treated mice.
    Journal of pineal research, 2017, Volume: 63, Issue:4

    Topics: Animals; Birth Injuries; Brain Injuries; Female; Inflammation; Lipopolysaccharides; Melatonin; Mice;

2017
Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2019, Volume: 82, Issue:3

    Topics: Animals; Brain Injuries; Disease Models, Animal; Female; Fetal Diseases; Hemodynamics; Humans; Immun

2019
Prenatal corticosteroids: pretermer outcomes, stress, schizophrenia, multiple sclerosis and the developmental role of melatonin and vitamin D3.
    Journal of pediatric and adolescent gynecology, 2010, Volume: 23, Issue:5

    Topics: Cholecalciferol; Dietary Supplements; Female; Humans; Hydrocortisone; Infant, Newborn; Melatonin; Mu

2010