melatonin has been researched along with Pre-Eclampsia in 34 studies
Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this systematic review is to access the current state of knowledge concerning the role for melatonin in human pregnancy." | 8.84 | Melatonin and pregnancy in the human. ( Flores, LJ; Manchester, LC; Nakamura, Y; Reiter, RJ; Sugino, N; Tamura, H; Tan, DX; Terron, MP, 2008) |
| " Melatonin is involved in the outcome of normal pregnancy." | 8.02 | Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia. ( Aref, M; El-Malkey, NF; Emam, H; Khalil, SS, 2021) |
| "Melatonin therapy was safe for mothers and their fetuses." | 6.87 | Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia. ( Alers, NO; Gurusinghe, S; Hobson, SR; Kingdom, JC; Lim, R; Miller, SL; Wallace, EM, 2018) |
| "Placental insufficiency affects about 10% of pregnancies and can lead to pre-eclampsia, fetal growth restriction, and preterm birth." | 6.82 | The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review. ( Bussolaro, S; Fantasia, I; Rolnik, DL; Stampalija, T, 2022) |
| "Treatment with melatonin might result in a wide range of health benefits, including improved quality of life and reduced healthcare costs." | 6.48 | Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period. ( Aversa, S; Barberi, I; Gitto, E; Pellegrino, S; Reiter, RJ, 2012) |
| "It also shows that preeclampsia is associated with a disruption of the circadian rhythm of placental cells." | 5.91 | Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia. ( Bretelle, F; Coiffard, B; Desbriere, R; Diallo, AB; Donato, X; Katsogiannou, M; Mege, JL; Mezouar, S, 2023) |
| "The study involved 32 women with preeclampsia and 33 healthy pregnant women as a control group." | 5.91 | Changes in concentrations of melatonin, PlGF, and cytokines in women with preeclampsia. ( Mykhailovych Barbe, A; Mykhailovych Yuzko, O; Mykolaiovych Berbets, A; Radu, MR; Savka, RF, 2023) |
| "Melatonin has an inhibitory effect on preeclampsia (PE)." | 5.72 | Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis. ( Chang, J; Chen, B; Feng, L; Liu, Z; Zhao, X, 2022) |
| "Melatonin is a hormone and antioxidant produced by the pineal gland and placenta." | 5.62 | Melatonin, a Potential Therapeutic Agent for Preeclampsia, Reduces the Extrusion of Toxic Extracellular Vesicles from Preeclamptic Placentae. ( Chamley, L; Chen, Q; Groom, K; Tang, Y, 2021) |
| "Melatonin did not increase HO-1 expression in any of the tissues examined." | 5.48 | Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia. ( Beard, S; Binder, NK; Hannan, NJ; Kaitu'u-Lino, TJ; Nguyen, TV; Tong, S, 2018) |
| "Serum was collected from women with preeclampsia (n=113) and gestation-matched healthy pregnant women, and the levels of melatonin were measured." | 5.43 | The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. ( Chen, Q; Gao, Y; Lee, AC; Tong, M; Wan, J; Zeng, K; Zhao, M, 2016) |
| "Melatonin plays pivotal role in biological circadian rhythms." | 5.40 | Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm. ( Arampatzis, S; Bouchlariotou, S; Eleftheriadis, T; Giannopoulou, M; Liakopoulos, V; Mertens, PR; Messinis, IE; Stefanidis, I; Zintzaras, E, 2014) |
| " The emerging evidence has proven that circadian rhythm deregulation followed by low circulating melatonin is associated with low implantation rates and difficulties to maintain pregnancy." | 5.01 | Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms. ( Chuffa, LGA; Cucielo, MS; Lupi, LA; Reiter, RJ; Seiva, FRF; Silveira, HS, 2019) |
| " Included in this group of conditions is asphyxia, respiratory distress syndrome and sepsis and the review also summarizes the literature related to clinical trials of antioxidant therapies and of melatonin, a highly effective antioxidant and free radical scavenger." | 4.85 | Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. ( Barberi, I; Gitto, E; Gitto, P; Pellegrino, S; Reiter, RJ, 2009) |
| "The purpose of this systematic review is to access the current state of knowledge concerning the role for melatonin in human pregnancy." | 4.84 | Melatonin and pregnancy in the human. ( Flores, LJ; Manchester, LC; Nakamura, Y; Reiter, RJ; Sugino, N; Tamura, H; Tan, DX; Terron, MP, 2008) |
| " Melatonin is involved in the outcome of normal pregnancy." | 4.02 | Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia. ( Aref, M; El-Malkey, NF; Emam, H; Khalil, SS, 2021) |
| "We assessed the correlation between the rhythm of melatonin concentration and circadian blood pressure patterns in normal and hypertensive pregnancy." | 3.72 | Circadian melatonin concentration rhythm is lost in pregnant women with altered blood pressure rhythm. ( Garbati, E; Giannubilo, SR; Tranquilli, AL; Turi, A, 2004) |
| "Melatonin therapy was safe for mothers and their fetuses." | 2.87 | Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia. ( Alers, NO; Gurusinghe, S; Hobson, SR; Kingdom, JC; Lim, R; Miller, SL; Wallace, EM, 2018) |
| "Placental insufficiency affects about 10% of pregnancies and can lead to pre-eclampsia, fetal growth restriction, and preterm birth." | 2.82 | The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review. ( Bussolaro, S; Fantasia, I; Rolnik, DL; Stampalija, T, 2022) |
| "Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which results in high amounts of circulating reactive oxygen species (ROS) and reactive nitrogen species (RNS)." | 2.66 | Oxidative stress: Normal pregnancy versus preeclampsia. ( Abad, C; Chiarello, DI; Marín, R; Mate, A; Rojas, D; Sobrevia, L; Toledo, F; Vázquez, CM, 2020) |
| "Treatment with melatonin might result in a wide range of health benefits, including improved quality of life and reduced healthcare costs." | 2.48 | Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period. ( Aversa, S; Barberi, I; Gitto, E; Pellegrino, S; Reiter, RJ, 2012) |
| "Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect." | 2.48 | Melatonin utility in neonates and children. ( Chen, YC; Huang, LT; Sheen, JM; Tain, YL, 2012) |
| "It also shows that preeclampsia is associated with a disruption of the circadian rhythm of placental cells." | 1.91 | Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia. ( Bretelle, F; Coiffard, B; Desbriere, R; Diallo, AB; Donato, X; Katsogiannou, M; Mege, JL; Mezouar, S, 2023) |
| "The study involved 32 women with preeclampsia and 33 healthy pregnant women as a control group." | 1.91 | Changes in concentrations of melatonin, PlGF, and cytokines in women with preeclampsia. ( Mykhailovych Barbe, A; Mykhailovych Yuzko, O; Mykolaiovych Berbets, A; Radu, MR; Savka, RF, 2023) |
| "Melatonin has an inhibitory effect on preeclampsia (PE)." | 1.72 | Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis. ( Chang, J; Chen, B; Feng, L; Liu, Z; Zhao, X, 2022) |
| "Melatonin is a hormone and antioxidant produced by the pineal gland and placenta." | 1.62 | Melatonin, a Potential Therapeutic Agent for Preeclampsia, Reduces the Extrusion of Toxic Extracellular Vesicles from Preeclamptic Placentae. ( Chamley, L; Chen, Q; Groom, K; Tang, Y, 2021) |
| "Melatonin did not increase HO-1 expression in any of the tissues examined." | 1.48 | Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia. ( Beard, S; Binder, NK; Hannan, NJ; Kaitu'u-Lino, TJ; Nguyen, TV; Tong, S, 2018) |
| "The exact cause of preeclampsia is unknown." | 1.46 | Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae. ( Chamley, LW; Chen, Q; Groom, K; Hickey, A; Li, Y; Stone, PR; Xu, L; Zhao, M, 2017) |
| "Serum was collected from women with preeclampsia (n=113) and gestation-matched healthy pregnant women, and the levels of melatonin were measured." | 1.43 | The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. ( Chen, Q; Gao, Y; Lee, AC; Tong, M; Wan, J; Zeng, K; Zhao, M, 2016) |
| "Melatonin plays pivotal role in biological circadian rhythms." | 1.40 | Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm. ( Arampatzis, S; Bouchlariotou, S; Eleftheriadis, T; Giannopoulou, M; Liakopoulos, V; Mertens, PR; Messinis, IE; Stefanidis, I; Zintzaras, E, 2014) |
| "Melatonin (6 mg) was administered orally at 12:00 hr, and samples of chorion and maternal blood were obtained at the time of the procedure, 1, 2 or 3 hr later." | 1.31 | Melatonin stimulates glutathione peroxidase activity in human chorion. ( Fukaya, T; Kaneda, C; Okatani, Y; Shinohara, K; Wakatsuki, A, 2001) |
| "Melatonin could be useful in treating preeclampsia and possibly other clinical states involving excess free radical production, such as fetal growth restriction and fetal hypoxia." | 1.31 | Melatonin protects against oxidative mitochondrial damage induced in rat placenta by ischemia and reperfusion. ( Fukaya, T; Okatani, Y; Shinohara, K; Taniguchi, K; Wakatsuki, A, 2001) |
| "Treatment with melatonin prior to exposure to H2O2 significantly restored the relaxation induced by A23187 (P < 0." | 1.30 | Melatonin inhibits vasospastic action of hydrogen peroxide in human umbilical artery. ( Hayashi, K; Okatani, Y; Sagara, Y; Wakatsuki, A; Watanabe, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 16 (47.06) | 24.3611 |
| 2020's | 8 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Chen, B | 1 |
| Chang, J | 1 |
| Feng, L | 1 |
| Zhao, X | 1 |
| Zhou, C | 1 |
| Ding, Y | 1 |
| Yu, L | 1 |
| Nie, Y | 1 |
| Yang, M | 1 |
| Fantasia, I | 1 |
| Bussolaro, S | 1 |
| Stampalija, T | 1 |
| Rolnik, DL | 1 |
| Diallo, AB | 1 |
| Coiffard, B | 1 |
| Desbriere, R | 1 |
| Katsogiannou, M | 1 |
| Donato, X | 1 |
| Bretelle, F | 1 |
| Mezouar, S | 1 |
| Mege, JL | 1 |
| Savka, RF | 1 |
| Mykolaiovych Berbets, A | 1 |
| Mykhailovych Barbe, A | 1 |
| Mykhailovych Yuzko, O | 1 |
| Radu, MR | 1 |
| Chuffa, LGA | 1 |
| Lupi, LA | 1 |
| Cucielo, MS | 1 |
| Silveira, HS | 1 |
| Reiter, RJ | 5 |
| Seiva, FRF | 1 |
| El-Malkey, NF | 1 |
| Aref, M | 1 |
| Emam, H | 1 |
| Khalil, SS | 1 |
| Tang, Y | 1 |
| Groom, K | 2 |
| Chamley, L | 1 |
| Chen, Q | 3 |
| Zhao, M | 3 |
| Li, Y | 1 |
| Xu, L | 1 |
| Hickey, A | 1 |
| Stone, PR | 1 |
| Chamley, LW | 1 |
| Hobson, SR | 3 |
| Lim, R | 2 |
| Wallace, EM | 3 |
| Kingdom, JC | 2 |
| Hodges, RJ | 1 |
| Uzun, M | 2 |
| Gencer, M | 1 |
| Turkon, H | 2 |
| Oztopuz, RO | 1 |
| Demir, U | 1 |
| Ovali, MA | 1 |
| Hannan, NJ | 1 |
| Binder, NK | 1 |
| Beard, S | 1 |
| Nguyen, TV | 1 |
| Kaitu'u-Lino, TJ | 1 |
| Tong, S | 1 |
| Gurusinghe, S | 1 |
| Alers, NO | 1 |
| Miller, SL | 1 |
| Chiarello, DI | 1 |
| Abad, C | 1 |
| Rojas, D | 1 |
| Toledo, F | 1 |
| Vázquez, CM | 1 |
| Mate, A | 1 |
| Sobrevia, L | 1 |
| Marín, R | 1 |
| Dou, Y | 1 |
| Lin, B | 1 |
| Cheng, H | 1 |
| Wang, C | 1 |
| Zhang, J | 1 |
| Wu, J | 1 |
| Doğanlar, ZB | 1 |
| Güçlü, H | 1 |
| Öztopuz, Ö | 1 |
| Dogan, A | 1 |
| Doğanlar, O | 1 |
| Bouchlariotou, S | 1 |
| Liakopoulos, V | 1 |
| Giannopoulou, M | 1 |
| Arampatzis, S | 1 |
| Eleftheriadis, T | 1 |
| Mertens, PR | 1 |
| Zintzaras, E | 1 |
| Messinis, IE | 1 |
| Stefanidis, I | 1 |
| Sagrillo-Fagundes, L | 1 |
| Soliman, A | 1 |
| Vaillancourt, C | 2 |
| Marseglia, L | 1 |
| D'Angelo, G | 1 |
| Manti, S | 1 |
| Gitto, E | 3 |
| Zeng, K | 1 |
| Gao, Y | 1 |
| Wan, J | 1 |
| Tong, M | 1 |
| Lee, AC | 1 |
| Pellegrino, S | 2 |
| Gitto, P | 1 |
| Barberi, I | 2 |
| Aversa, S | 1 |
| Chen, YC | 1 |
| Tain, YL | 1 |
| Sheen, JM | 1 |
| Huang, LT | 1 |
| Lanoix, D | 1 |
| Guérin, P | 1 |
| Tranquilli, AL | 1 |
| Turi, A | 1 |
| Giannubilo, SR | 1 |
| Garbati, E | 1 |
| Tamura, H | 2 |
| Nakamura, Y | 2 |
| Terron, MP | 1 |
| Flores, LJ | 1 |
| Manchester, LC | 1 |
| Tan, DX | 1 |
| Sugino, N | 2 |
| Kennaway, DJ | 1 |
| Goble, FC | 1 |
| Stamp, GE | 1 |
| Okatani, Y | 4 |
| Watanabe, K | 2 |
| Hayashi, K | 1 |
| Wakatsuki, A | 4 |
| Sagara, Y | 1 |
| Morioka, N | 1 |
| Milczarek, R | 1 |
| Klimek, J | 1 |
| Zelewski, L | 1 |
| Kashida, S | 1 |
| Takayama, H | 1 |
| Yamagata, Y | 1 |
| Karube, A | 1 |
| Kato, H | 1 |
| Shinohara, K | 2 |
| Kaneda, C | 1 |
| Fukaya, T | 2 |
| Taniguchi, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prognostic Value of Serum Melatonin as a Biomarker for the Determination of Severe COVID-19 Infection in Pregnant Women[NCT05318144] | 228 participants (Actual) | Observational [Patient Registry] | 2021-06-01 | Completed | |||
| Melatonin for Neuroprotection Following Perinatal Asphyxia[NCT02071160] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for melatonin and Pre-Eclampsia
| Article | Year |
|---|---|
The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review.
Topics: Antioxidants; Aspirin; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Melatonin; Placent | 2022 |
Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms.
Topics: Abortion, Habitual; Circadian Rhythm; Endometriosis; Endometrium; Female; Humans; Melatonin; Menstru | 2019 |
Oxidative stress: Normal pregnancy versus preeclampsia.
Topics: Animals; Antioxidants; Endothelial Cells; Female; Free Radicals; Humans; Ischemia; Melatonin; Oxidat | 2020 |
The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis.
Topics: Female; Humans; Melatonin; Pre-Eclampsia; Pregnancy | 2019 |
Maternal and placental melatonin: actions and implication for successful pregnancies.
Topics: Animals; Antioxidants; Biomarkers; Female; Humans; Melatonin; Oxidative Stress; Placenta; Pre-Eclamp | 2014 |
Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia.
Topics: Animals; Antioxidants; Asphyxia Neonatorum; Female; Fetal Growth Retardation; Humans; Infant, Newbor | 2016 |
Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin.
Topics: Animals; Asphyxia Neonatorum; Clinical Trials as Topic; Female; Free Radical Scavengers; Humans; Inf | 2009 |
Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period.
Topics: Adult; Antioxidants; Female; Humans; Infant, Newborn; Melatonin; Oxidative Stress; Perinatal Care; P | 2012 |
Melatonin utility in neonates and children.
Topics: Antioxidants; Child; Female; Fetal Growth Retardation; Humans; Hypoxia-Ischemia, Brain; Infant, Newb | 2012 |
Melatonin and pregnancy in the human.
Topics: Abortion, Spontaneous; Circadian Rhythm; Female; Fetal Development; Fetal Hypoxia; Humans; Maternal- | 2008 |
1 trial available for melatonin and Pre-Eclampsia
| Article | Year |
|---|---|
Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia.
Topics: Adult; Endothelium, Vascular; Female; Humans; Melatonin; Pre-Eclampsia; Pregnancy | 2018 |
23 other studies available for melatonin and Pre-Eclampsia
| Article | Year |
|---|---|
Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis.
Topics: Cell Movement; Cell Proliferation; Female; High-Temperature Requirement A Serine Peptidase 1; Histon | 2022 |
Melatonin regulates proliferation, apoptosis and invasion of trophoblasts in preeclampsia by inhibiting endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Endoplasmic Reticulum Stress; Female; Humans; | 2022 |
Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia.
Topics: Animals; Circadian Rhythm; CLOCK Proteins; Female; Humans; Melatonin; Placenta; Pre-Eclampsia; Pregn | 2023 |
Changes in concentrations of melatonin, PlGF, and cytokines in women with preeclampsia.
Topics: Biomarkers; Cytokines; Female; Humans; Interleukin-10; Interleukin-6; Melatonin; Placenta; Placenta | 2023 |
Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia.
Topics: Animals; Brain; Disease Models, Animal; Female; Malondialdehyde; Melatonin; Oxidative Stress; Placen | 2021 |
Melatonin, a Potential Therapeutic Agent for Preeclampsia, Reduces the Extrusion of Toxic Extracellular Vesicles from Preeclamptic Placentae.
Topics: Adult; Cell Line; Endothelial Cells; Extracellular Vesicles; Female; Humans; Intercellular Adhesion | 2021 |
Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae.
Topics: Adult; Antibodies, Antiphospholipid; Endothelial Cells; Extracellular Vesicles; Female; Humans; Mela | 2017 |
Phase I Pilot Clinical Trial of Antenatal Maternally Administered Melatonin to Decrease the Level of Oxidative Stress in Human Pregnancies Affected by Preeclampsia.
Topics: Antioxidants; Clinical Trials, Phase I as Topic; Female; Humans; Melatonin; Oxidative Stress; Pilot | 2018 |
A Randomized Double-Blinded Placebo-Controlled Intervention Trial of Melatonin for the Prevention of Preeclampsia in Moderate- and High-Risk Women: The MELPOP Trial.
Topics: Antioxidants; Double-Blind Method; Female; Humans; Melatonin; Oxidative Stress; Placebo Effect; Pre- | 2018 |
Effects of Melatonin on Blood Pressure, Oxidative Stress and Placental Expressions of TNFα, IL-6, VEGF and sFlt-1 in RUPP Rat Model of Preeclampsia.
Topics: Animals; Biomarkers; Blood Pressure; Female; Interleukin-6; Melatonin; Oxidative Stress; Placenta; P | 2017 |
Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia.
Topics: Antioxidants; Female; Gene Expression Regulation; Humans; Melatonin; Placenta; Pre-Eclampsia; Pregna | 2018 |
The Role of Melatonin in Oxidative Stress, DNA Damage, Apoptosis and Angiogenesis in Fetal Eye under Preeclampsia and Melatonin Deficiency Stress.
Topics: Animals; Apoptosis; Aryl Hydrocarbon Receptor Nuclear Translocator; Blotting, Western; DNA Damage; E | 2019 |
Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm.
Topics: Adult; Blood Pressure; Case-Control Studies; Circadian Rhythm; Female; Humans; Melatonin; Postpartum | 2014 |
The reduction in circulating levels of melatonin may be associated with the development of preeclampsia.
Topics: Biomarkers; China; Down-Regulation; Female; Hospitals, Teaching; Humans; Incidence; Melatonin; Place | 2016 |
Placental melatonin production and melatonin receptor expression are altered in preeclampsia: new insights into the role of this hormone in pregnancy.
Topics: Acetylserotonin O-Methyltransferase; Adult; Arylalkylamine N-Acetyltransferase; Blotting, Western; C | 2012 |
Circadian melatonin concentration rhythm is lost in pregnant women with altered blood pressure rhythm.
Topics: Blood Pressure; Circadian Rhythm; Female; Gestational Age; Humans; Hypertension; Melatonin; Pre-Ecla | 2004 |
Factors influencing the development of melatonin rhythmicity in humans.
Topics: Birth Weight; Cesarean Section; Female; Fetal Growth Retardation; Fetal Membranes, Premature Rupture | 1996 |
Melatonin inhibits vasospastic action of hydrogen peroxide in human umbilical artery.
Topics: Antioxidants; Female; Free Radical Scavengers; Humans; Hydrogen Peroxide; In Vitro Techniques; Infan | 1997 |
Melatonin inhibits the vasorelaxant action of peroxynitrite in human umbilical artery.
Topics: Antioxidants; Female; Free Radical Scavengers; Humans; In Vitro Techniques; Melatonin; Molsidomine; | 1999 |
Melatonin inhibits NADPH-dependent lipid peroxidation in human placental mitochondria.
Topics: Antioxidants; Ascorbic Acid; Female; Humans; Lipid Peroxidation; Melatonin; Mitochondria; NADP; Plac | 2000 |
Changes of serum melatonin level and its relationship to feto-placental unit during pregnancy.
Topics: Adult; Circadian Rhythm; Female; Fetal Growth Retardation; Humans; Melatonin; Pre-Eclampsia; Pregnan | 2001 |
Melatonin stimulates glutathione peroxidase activity in human chorion.
Topics: Abortion, Induced; Chorion; Enzyme Activation; Female; Fetal Growth Retardation; Free Radical Scaven | 2001 |
Melatonin protects against oxidative mitochondrial damage induced in rat placenta by ischemia and reperfusion.
Topics: Adenosine Diphosphate; Animals; Female; Fetal Growth Retardation; Humans; Melatonin; Mitochondria; O | 2001 |