Page last updated: 2024-10-19

melatonin and Postoperative Complications

melatonin has been researched along with Postoperative Complications in 66 studies

Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Research Excerpts

ExcerptRelevanceReference
"Experimental evidence has indicated the benefits of melatonin (Mel) for the treatment of delirium."9.41Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial. ( Shi, Y, 2021)
"Melatonin may be effective in reducing the severity of delirium after cardiac surgery."9.41Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. ( Janatmakan, F; Javaherforoosh Zadeh, F; Jorairahmadi, S; Shafaeebejestan, E, 2021)
" Forty-two participants developed delirium, but it was evenly distributed between the groups (melatonin 21/98, 21."9.34The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Kelly, R; Passage, J; Patel, H; Wibrow, B, 2020)
"The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia."9.24The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial. ( Fan, Y; Gao, D; Ji, M; Yang, J; Yuan, L, 2017)
"The Healthy Heart-Mind trial is a randomized, double-blind, placebo-controlled clinical trial of 3 mg melatonin or matching placebo administered on seven consecutive days for the prevention of delirium following cardiac surgery."9.22The Healthy Heart-Mind trial: melatonin for prevention of delirium following cardiac surgery: study protocol for a randomized controlled trial. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Passage, J; Wibrow, B, 2016)
"Postoperative tryptophan supplementation in older adults undergoing major elective operations requiring postoperative ICU admission did not reduce the incidence or duration of postoperative excitatory delirium or overall delirium."9.19Tryptophan supplementation and postoperative delirium--a randomized controlled trial. ( Adams, JC; Dunn, CL; Hawkins, CL; Moss, M; Raeburn, CD; Robinson, TN; Tran, ZV, 2014)
"Midazolam is more effective than melatonin in reducing children's anxiety at induction of anesthesia."9.14Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. ( Hata, J; Herrmann, L; Kain, ZN; Lerman, J; MacLaren, JE; Mayes, L; Rosenbaum, A, 2009)
"To assess the effects of melatonin on preoperative and postoperative anxiety compared to placebo or benzodiazepines."9.05Melatonin for preoperative and postoperative anxiety in adults. ( Madsen, BK; Møller, AM; Rosenberg, J; Zetner, D, 2020)
"To assess the significance of melatonin, NT-proBNP and morphological markers of myocardial remodeling for predicting the risk of complications after coronary artery bypass grafting (CABG) in patients with ischemic heart disease and chronic heart failure (CHF)."7.85[Prognostic Value of Melatonin Level, Structural and Functional Changes of the Myocardium in the Development of Complications in Patients With Heart Failure who Underwent Coronary Artery Bypass Grafting: the Possibilities of Pharmacological Cardioprotecti ( Avchenko, GM; Erkhov, AY; Liskova, YV; Popov, AB; Rozhkov, VO; Salikova, SP; Selivanov, SA; Stadnikov, AA; Tverdokhlib, NB, 2017)
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium."7.83Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016)
"To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality."7.80Sleep-wake and melatonin pattern in craniopharyngioma patients. ( Feldt-Rasmussen, U; Gammeltoft, S; Jennum, P; Klose, M; Pickering, L; Poulsgaard, L, 2014)
"To determine whether suppression of melatonin secretion without surgery in chickens can result in scoliosis development."7.72Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy. ( Cheung, KM; Leong, JC; Lu, DS; Luk, KD; Poon, AM; Wang, T, 2003)
"Abnormal melatonin secretion may be involved in postoperative sleep disturbances, which triggered delirium in elderly patients."7.71Postoperative delirium and melatonin levels in elderly patients. ( Ikeda, K; Kageyama, M; Machida, N; Menjo, M; Miura, M; Nimura, Y; Shigeta, H; Yasui, A, 2001)
"Melatonin has been mentioned as a protective factor against acute pancreatitis."5.51Does melatonin addition to indomethacin decrease post endoscopic retrograde cholangiopancreatography pancreatitis? A randomized double-blind controlled trial. ( Abbasinazari, M; Abdi, S; Asadzadeh Aghdaei, H; Hatami, B; Jamshidzadeh, S; Rasoolinezhad, M; Saadati, S; Sadeghi, A, 2019)
"Melatonin has been considered as an effective remedy for circadian rhythm shift."5.48Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018)
"Experimental evidence has indicated the benefits of melatonin (Mel) for the treatment of delirium."5.41Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial. ( Shi, Y, 2021)
"Melatonin may be effective in reducing the severity of delirium after cardiac surgery."5.41Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. ( Janatmakan, F; Javaherforoosh Zadeh, F; Jorairahmadi, S; Shafaeebejestan, E, 2021)
"Patients with breast cancer undergoing lumpectomy had significantly disturbed sleep architecture the night after surgery, and these changes were normalised after 2 weeks."5.39Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy. ( Gögenur, I; Hansen, MV; Madsen, MT; Rosenberg, J; Wildschiødtz, G, 2013)
" Forty-two participants developed delirium, but it was evenly distributed between the groups (melatonin 21/98, 21."5.34The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Kelly, R; Passage, J; Patel, H; Wibrow, B, 2020)
"Postoperative delirium is a common problem associated with increased morbidity and mortality, prolonged hospital stay, additional tests and consultations and therefore, increased cost (1,2)."5.31Melatonin for treatment and prevention of postoperative delirium. ( Hanania, M; Kitain, E, 2002)
"The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia."5.24The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial. ( Fan, Y; Gao, D; Ji, M; Yang, J; Yuan, L, 2017)
" We assessed the effect of melatonin on postoperative complications of canine cataract surgery."5.22Preliminary findings on the effect of melatonin on the clinical outcome of cataract surgery in dogs. ( Álvarez, J; Calcagno, J; Rosenstein, RE; Sande, PH, 2016)
"The Healthy Heart-Mind trial is a randomized, double-blind, placebo-controlled clinical trial of 3 mg melatonin or matching placebo administered on seven consecutive days for the prevention of delirium following cardiac surgery."5.22The Healthy Heart-Mind trial: melatonin for prevention of delirium following cardiac surgery: study protocol for a randomized controlled trial. ( Almeida, OP; Anstey, M; Edwards, M; Flicker, L; Ford, AH; Passage, J; Wibrow, B, 2016)
"Postoperative tryptophan supplementation in older adults undergoing major elective operations requiring postoperative ICU admission did not reduce the incidence or duration of postoperative excitatory delirium or overall delirium."5.19Tryptophan supplementation and postoperative delirium--a randomized controlled trial. ( Adams, JC; Dunn, CL; Hawkins, CL; Moss, M; Raeburn, CD; Robinson, TN; Tran, ZV, 2014)
"Midazolam is more effective than melatonin in reducing children's anxiety at induction of anesthesia."5.14Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. ( Hata, J; Herrmann, L; Kain, ZN; Lerman, J; MacLaren, JE; Mayes, L; Rosenbaum, A, 2009)
"To assess the effects of melatonin on preoperative and postoperative anxiety compared to placebo or benzodiazepines."5.05Melatonin for preoperative and postoperative anxiety in adults. ( Madsen, BK; Møller, AM; Rosenberg, J; Zetner, D, 2020)
"Melatonin intervention has no significant influence on well-being, sleepiness, sleep quality, pain intensity after 1 and 3 hours, headache, depression, and dizziness for laparoscopic cholecystectomy."5.01The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials. ( Wang, Y; Xu, H; Yang, J; Zhang, J, 2019)
", risperidone or olanzapine), and melatonin may be effective in reducing the incidence of postoperative delirium, but the data are not robust."4.90Pharmacologic prevention of postoperative delirium. ( Gosch, M; Nicholas, JA, 2014)
"Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
" Flap necrosis rates and melatonin, oxidant, and antioxidant factors were studied."4.31Time-related variations in viability of random pattern skin flaps: An experimental study in rats. ( Aydin, OE; Ceylan, E; Cicek, K; Demir, N; Pehlevan, A; Tuzcu, A, 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
"To assess the significance of melatonin, NT-proBNP and morphological markers of myocardial remodeling for predicting the risk of complications after coronary artery bypass grafting (CABG) in patients with ischemic heart disease and chronic heart failure (CHF)."3.85[Prognostic Value of Melatonin Level, Structural and Functional Changes of the Myocardium in the Development of Complications in Patients With Heart Failure who Underwent Coronary Artery Bypass Grafting: the Possibilities of Pharmacological Cardioprotecti ( Avchenko, GM; Erkhov, AY; Liskova, YV; Popov, AB; Rozhkov, VO; Salikova, SP; Selivanov, SA; Stadnikov, AA; Tverdokhlib, NB, 2017)
"Preoperative CSF melatonin levels did not differ between patients with and without postoperative delirium."3.83Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study. ( de Rooij, SE; Scholtens, RM; van Munster, BC; Vellekoop, AE; Vrouenraets, BC, 2016)
"To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality."3.80Sleep-wake and melatonin pattern in craniopharyngioma patients. ( Feldt-Rasmussen, U; Gammeltoft, S; Jennum, P; Klose, M; Pickering, L; Poulsgaard, L, 2014)
"To determine whether suppression of melatonin secretion without surgery in chickens can result in scoliosis development."3.72Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy. ( Cheung, KM; Leong, JC; Lu, DS; Luk, KD; Poon, AM; Wang, T, 2003)
"Abnormal melatonin secretion may be involved in postoperative sleep disturbances, which triggered delirium in elderly patients."3.71Postoperative delirium and melatonin levels in elderly patients. ( Ikeda, K; Kageyama, M; Machida, N; Menjo, M; Miura, M; Nimura, Y; Shigeta, H; Yasui, A, 2001)
"The study seems to show a possible correlation between impaired rhythm of melatonin secretion and postoperative insomnia and postoperative sepsis in old patients undergoing surgery."3.70[The role of melatonin in the immediate postoperative period in elderly patients]. ( Barnabei, R; Cianca, G; Citone, G; Leardi, S; Necozione, S; Simi, M; Tavone, E, 2000)
"After rectal cancer surgery, a majority of patients suffer from sequelae known as low anterior resection syndrome (LARS)."3.30Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial. ( Bulut, O; Christensen, P; Gögenur, I; Madsen, MT; Zahid, JA, 2023)
"Melatonin was effectively absorbed with serum concentrations of 1142."2.76The use of high-dose melatonin in liver resection is safe: first clinical experience. ( Bruns, H; Büchler, MW; Cekauskas, A; Gotthardt, DN; Hinz, U; Manikas, M; Mikalauskas, S; Mikalauskene, L; Nickkholgh, A; Pelzl, le H; Schemmer, P; Schneider, H; Sobirey, M; Venetz, WP; Weigand, MA; Zorn, M, 2011)
"Postoperative delirium is a common sequela in older adults in the peri-operative period leading to poor outcomes with a complex pathophysiology which has led to a variety of different pharmacologic agents employed in attempts to prevent and treat this syndrome."2.66The pharmacotherapeutic management of postoperative delirium: an expert update. ( Scicutella, A, 2020)
"Patients with cancer frequently experience unintended weight loss due to gastrointestinal (GI) dysfunction caused by the malignancy or treatment of the malignancy."2.55Cancer Cachexia: Cause, Diagnosis, and Treatment. ( Mattox, TW, 2017)
"Melatonin is a neuroendocrine regulator of the sleep-wake cycle."1.62Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice. ( Guo, X; Han, Y; Jia, X; Li, Z; Liu, C; Liu, Y; Shi, C; Shi, J; Song, Y; Sun, J; Sun, Z; Yang, N; Yuan, Y; Zhang, L; Zhang, W; Zhou, Y, 2021)
"Melatonin has been mentioned as a protective factor against acute pancreatitis."1.51Does melatonin addition to indomethacin decrease post endoscopic retrograde cholangiopancreatography pancreatitis? A randomized double-blind controlled trial. ( Abbasinazari, M; Abdi, S; Asadzadeh Aghdaei, H; Hatami, B; Jamshidzadeh, S; Rasoolinezhad, M; Saadati, S; Sadeghi, A, 2019)
"Melatonin has been considered as an effective remedy for circadian rhythm shift."1.48Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018)
"Melatonin is a hormone with well-known chronobiotic and hypnotic effects."1.40Chronobiology, cognitive function and depressive symptoms in surgical patients. ( Hansen, MV, 2014)
"Patients with breast cancer undergoing lumpectomy had significantly disturbed sleep architecture the night after surgery, and these changes were normalised after 2 weeks."1.39Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy. ( Gögenur, I; Hansen, MV; Madsen, MT; Rosenberg, J; Wildschiødtz, G, 2013)
"Rosiglitazone group had lower adhesion scores [median (min-max ranges)] regarding extent, severity, and degree of the adhesions [0 (0-3), 0 (0-3) and 0 (0-3), respectively], which were significantly different (P < 0."1.36A randomised controlled trial on melatonin and rosiglitazone for prevention of adhesion formation in a rat uterine horn model. ( Aksakal, O; Gungor, T; Inan, I; Kalyoncu, S; Mollamahmutoglu, L; Sirvan, L; Sut, N; Yilmaz, B, 2010)
" Dosage was in accordance with their pharmacokinetic properties and experience gained with experimental SCI."1.35Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. ( Franco-Bourland, RE; Grijalva, I; Guízar-Sahagún, G; Ibarra, A; Madrazo, I; Martínez-Cruz, A; Rodríguez-Balderas, CA, 2009)
"Melatonin has not been used in adult patients with acute oxidative stress."1.34[Melatonin against surgical stress]. ( Gögenur, I; Kücükakin, B; Rosenberg, J, 2007)
"Postoperative delirium is a common problem associated with increased morbidity and mortality, prolonged hospital stay, additional tests and consultations and therefore, increased cost (1,2)."1.31Melatonin for treatment and prevention of postoperative delirium. ( Hanania, M; Kitain, E, 2002)

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.52)18.7374
1990's1 (1.52)18.2507
2000's21 (31.82)29.6817
2010's31 (46.97)24.3611
2020's12 (18.18)2.80

Authors

AuthorsStudies
Shi, Y1
Zahid, JA1
Madsen, MT3
Bulut, O1
Christensen, P1
Gögenur, I6
Aydin, OE1
Cicek, K1
Ceylan, E1
Tuzcu, A1
Pehlevan, A1
Demir, N1
Sadeghi, A1
Abbasinazari, M1
Asadzadeh Aghdaei, H1
Abdi, S1
Hatami, B1
Rasoolinezhad, M1
Jamshidzadeh, S1
Saadati, S1
Ford, AH2
Flicker, L2
Kelly, R1
Patel, H1
Passage, J2
Wibrow, B2
Anstey, M2
Edwards, M2
Almeida, OP2
Scicutella, A1
Shen, QH1
Li, HF1
Zhou, XY1
Lu, YP1
Yuan, XZ1
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Li, J1
Zhang, J2
Shen, S1
Zhang, B2
Yu, WW1
Toyoda, H1
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Zhu, L1
Wang, J7
Xue, L1
Liu, L2
Yan, X2
Huang, S1
Li, Y7
Xu, T1
Li, C2
Ji, F1
Ming, F1
Zhao, Y2
Cheng, J1
Wang, Y4
Zhao, H1
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X2
Chen, Y4
Wei, J1
Zhu, C1
Wu, C1
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Liu, C5
Lin, Y1
Dong, Y1
Wu, Y2
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
Alfawares, R1
Alobaid, A1
Rasheed, A1
Soliman, I1
Wendel Garcia, PD1
Fumeaux, T1
Guerci, P1
Heuberger, DM1
Montomoli, J2
Roche-Campo, F1
Schuepbach, RA1
Hilty, MP1
Poloni, TE1
Carlos, AF1
Cairati, M1
Cutaia, C1
Medici, V1
Marelli, E1
Ferrari, D1
Galli, A1
Bognetti, P1
Davin, A1
Cirrincione, A1
Ceretti, A1
Cereda, C1
Ceroni, M1
Tronconi, L1
Vitali, S1
Guaita, A1
Leeds, JS1
Raviprakash, V1
Jacques, T1
Scanlon, N1
Cundall, J1
Leeds, CM1
Riva, A1
Gray, EH1
Azarian, S1
Zamalloa, A1
McPhail, MJW1
Vincent, RP1
Williams, R1
Chokshi, S1
Patel, VC1
Edwards, LA1
Alqarawi, W1
Birnie, DH1
Golian, M1
Nair, GM1
Nery, PB1
Klein, A1
Davis, DR1
Sadek, MM1
Neilipovitz, D1
Johnson, CB1
Green, MS1
Redpath, C1
Miller, DC1
Beamer, P1
Billheimer, D1
Subbian, V1
Sorooshian, A1
Campbell, BS1
Mosier, JM1
Novaretti, JV1
Astur, DC1
Cavalcante, ELB1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Huang, W1
Li, T1
Ling, Y1
Qian, ZP1
Zhang, YY1
Huang, D1
Xu, SB1
Liu, XH1
Xia, L1
Yang, Y3
Lu, SH1
Lu, HZ1
Zhang, R2
Ma, JX1
Tang, S1
Li, CM1
Wan, J1
Wang, JF1
Ma, JQ1
Luo, JJ1
Chen, HY2
Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Hu, Y1
Shen, P1
Zeng, N1
Wang, L3
Yan, D1
Cui, L1
Yang, K2
Zhai, C1
Yang, M1
Lao, X1
Sun, J2
Ma, N1
Wang, S1
Ye, W1
Guo, P1
Rahimi, S1
Singh, MP1
Gupta, J1
Nakanishi, I1
Ohkubo, K1
Shoji, Y1
Fujitaka, Y1
Shimoda, K1
Matsumoto, KI1
Fukuhara, K1
Hamada, H1
van der Boom, T1
Gruppen, EG1
Lefrandt, JD1
Connelly, MA1
Links, TP1
Dullaart, RPF1
Berry, JD1
Bedlack, R1
Mathews, D1
Agnese, W1
Apple, S1
Meloncelli, S1
Divizia, M1
Germani, G1
Adefegha, SA1
Bottari, NB1
Leal, DB1
de Andrade, CM1
Schetinger, MR1
Martínez-Velasco, A1
Perez-Ortiz, AC1
Antonio-Aguirre, B1
Martínez-Villaseñor, L1
Lira-Romero, E1
Palacio-Pastrana, C1
Zenteno, JC1
Ramirez, I1
Zepeda-Palacio, C1
Mendoza-Velásquez, C1
Camacho-Ordóñez, A1
Ortiz Bibriesca, DM1
Estrada-Mena, FJ1
Martin, BL1
Thompson, LC1
Kim, YH2
Snow, SJ1
Schladweiler, MC1
Phillips, P1
Harmon, M1
King, C1
Richards, J1
George, I1
Haykal-Coates, N1
Gilmour, MI1
Kodavanti, UP1
Hazari, MS1
Farraj, AK1
Shen, Z1
Zou, Y1
Gao, K1
Lazar, S1
Wurtzel, JGT1
Ma, P1
Goldfinger, LE1
Vukelic, M1
Laloo, A1
Kyttaris, VC1
Chen, R1
Chen, J2
Xun, J1
Hu, Z1
Huang, Q2
Steinhart, C1
Shen, Y1
Lu, H1
Mansuri, A1
Lokhande, K1
Kore, S1
Gaikwad, S1
Nawani, N1
Swamy, KV1
Junnarkar, M1
Pawar, S1
Shaheen, MY1
Basudan, AM1
Niazy, AA1
van den Beucken, JJJP1
Jansen, JA1
Alghamdi, HS1
Gao, Q2
Guo, X3
Cao, Y1
Jia, X3
Xu, S1
Lu, C2
Zhu, H2
Melku, M1
Abebe, G1
Teketel, A1
Asrie, F1
Yalew, A1
Biadgo, B1
Kassa, E1
Damtie, D1
Anlay, DZ1
Ahmed, MFE1
Ramadan, H1
Seinige, D1
Kehrenberg, C1
Abd El-Wahab, A1
Volkmann, N1
Kemper, N1
Schulz, J1
Hu, MY1
Wu, YN1
McEvoy, MP1
Wang, YF1
Cong, WL1
Liu, LP1
Li, XX1
Zhou, CL1
Chen, WM1
Wei, KL1
Tung, SY1
Shen, CH1
Chang, TS1
Yen, CW1
Hsieh, YY1
Chiu, WN1
Hu, JH1
Lu, SN1
Hung, CH1
Alakavuklar, MA1
Fuqua, C1
Luo, KL1
Underwood, RS1
Greenwald, I1
Elashiry, MM1
Elashiry, M1
Zeitoun, R1
Elsayed, R1
Tian, F1
Saber, SE1
Elashry, SH1
Tay, FR1
Cutler, CW1
O'Dowd, A1
Maciel, M1
Poole, ST1
Jobling, MG1
Rollenhagen, JE1
Woods, CM1
Sincock, SA1
McVeigh, AL1
Gregory, MJ1
Maves, RC1
Prouty, MG1
Holmes, RK1
Savarino, SJ1
Mor, MK1
Palevsky, PM1
Kaufman, JS1
Thiessen Philbrook, H1
Weisbord, SD1
Parikh, CR1
John, CM1
Phillips, NJ1
Jarvis, GA1
Zhu, Y1
Kilburn, S1
Kapoor, M1
Chaturvedi, S1
Shaw, KJ1
Chaturvedi, V1
Kong, X1
Zhang, T1
Xiao, H1
Feng, X2
Tu, H1
Feng, J1
Sabet, M1
Tarazi, Z1
Griffith, DC1
Nguyen, F1
Guan, P1
Guerrero, DT1
Kolla, V1
Naraparaju, K1
Perry, LM1
Soberman, D1
Pressly, BB1
Alferiev, IS1
Chorny, M1
Brodeur, GM1
Gao, X2
Cheng, YH1
Enten, GA1
DeSantis, AJ1
Gaponenko, V1
Majetschak, M1
Kim, DY1
Choi, MJ1
Ko, TK1
Lee, NH1
Kim, OH1
Cheon, HG1
Cai, H1
Yip, V1
Lee, MV1
Wong, S1
Saad, O1
Ma, S1
Ljumanovic, N1
Khojasteh, SC1
Kamath, AV1
Shen, BQ1
Cuypers, ML1
Chanteux, H1
Gillent, E1
Bonnaillie, P1
Saunders, K1
Beckers, C1
Delatour, C1
Dell'Aiera, S1
Ungell, AL1
Nicolaï, J1
Knapp, AK1
Chen, A1
Griffin-Nolan, RJ1
Baur, LE1
Carroll, CJW1
Gray, JE1
Hoffman, AM1
Li, X5
Post, AK1
Slette, IJ1
Collins, SL1
Luo, Y1
Smith, MD1
Temitayo, GI1
Olawande, B1
Emmanuel, YO1
Timothy, AT1
Kehinde, O1
Susan, LF1
Ezra, L1
Joseph, OO1
Lev, S1
Desmarini, D1
Liuwantara, D1
Sorrell, TC1
Hawthorne, WJ1
Djordjevic, JT1
Verso, MG1
Costantino, C1
Marrella, A1
Immordino, P1
Vitale, F1
Amodio, E1
Wang, YD1
Yao, WL1
Xin, ZM1
Han, TT1
Wang, ZG1
Chen, L1
Cai, C1
Zhang, Y4
Ba, D1
Wen, S1
Tian, Q1
Lv, W1
Cheng, G1
Li, N1
Yue, XY1
Chu, WJ1
Chen, Q1
Choi, ES1
Zhao, X3
Zhou, HD1
Sun, XF1
Sharma, S2
Chhoker, S1
Xie, C1
Ong, EWY1
Tan, ZK1
Evans, S1
Weinheimer, CJ1
Kovacs, A1
Williams, JW1
Randolph, GJ1
Jiang, W1
Barger, PM1
Mann, DL1
Liu, J2
Huang, Y1
Kong, L1
Yu, X1
Feng, B1
Liu, D1
Zhao, B1
Mendes, GC1
Yuan, P1
Ge, D1
Wang, WM1
Fontes, EPB1
Li, P1
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Clinical Trials (14)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309]Phase 325 participants (Actual)Interventional2016-07-31Completed
SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477]40 participants (Anticipated)Interventional2024-07-31Not yet recruiting
Anxiolytic and Analgesic Effects of Melatonin: A Randomized, Double-blinded, Placebo-controlled Clinical Study[NCT02386319]Phase 336 participants (Actual)Interventional2016-08-31Completed
Perioperative Analgesic and Anxiolytic Effect of Melatonin in Patients Undergoing Lumbar Laminectomy[NCT01126294]84 participants (Anticipated)Interventional2010-04-30Recruiting
Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950]104 participants (Anticipated)Interventional2017-06-26Recruiting
The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome[NCT02451293]Phase 2/Phase 3252 participants (Actual)Interventional2016-01-18Completed
Assessing Quality of Life and the Feasibility of a Nutrition and Pharmacological Algorithm for Oncology Patients With Anorexia[NCT04155008]Phase 41 participants (Actual)Interventional2021-03-01Terminated (stopped due to The trial was closed after 4 months due to slow to accrual. Only 1 participant was enrolled.)
Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit[NCT03659760]40 participants (Anticipated)Interventional2018-09-03Recruiting
Role of Endogenous Melatonin Level in Preoperative and Postoperative Anxiety in Bariatric Surgery Patients[NCT03109054]50 participants (Anticipated)Observational2017-03-15Enrolling by invitation
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599]Phase 286 participants (Actual)Interventional2016-07-31Completed
Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.[NCT03107702]35 participants (Anticipated)Observational2017-03-29Enrolling by invitation
Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465]50 participants (Actual)Interventional2012-02-29Completed
Usefulness of Bright Light Therapy in the Prevention of Delirium in Patients Undergoing Hematopoietic Stem Cell Transplant (HSCT)[NCT01700816]40 participants (Actual)Interventional2012-10-31Terminated (stopped due to Low incidence of delirium.)
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172]Phase 260 participants (Actual)Interventional2014-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Preoperative Anxiety

"The State scale of the State-Trait Anxiety Inventory (STAI). Construct: Current level of anxiety. Scale range: 20-40 (higher scores indicate higher level of current anxiety) Scores are calculated according to the STAI scoring manual by adding point from each item (possible point for each item is 1-4)." (NCT02386319)
Timeframe: 60 minutes preoperative

Interventionscore on a scale (Median)
Melatonin27
Placebo28

Postoperative Hospital Stay

Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days

Interventiondays (Median)
Morphine7
Levobupivacaine7

Changes in C-reactive Protein (CRP) Levels

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

,
Interventionmg/L (Median)
Before surgery24 h after surgery72 h after surgery120 h after surgery
Levobupivacaine57.898.19554.6
Morphine57.2106.2118.566.9

Changes in Cognitive Function

"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery

,
Interventionscore on a scale (Median)
Before surgery24 h after surgery48 h after surgery72 h after surgery96 h after surgery120 h after surgery
Levobupivacaine222221212122
Morphine212020202020

Changes in Fibrinogen Concentrations in Peripheral Blood

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

,
Interventiong/L (Median)
Before surgery24 h after surgery72 h after surgery120 h after surgery
Levobupivacaine4.54.75.25
Morphine5.55.35.75.4

Changes in Pain Intensity

"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge

,
Interventionscore on a scale (Median)
3,6,9,12,15,18,21 and 24h after surgery27,30,33,36,39,42,45 and 48h after surgery51,54,57,60,63,66,69 and 72h after surgery4. postoperative day (every 8 hours)5. postoperative day (every 8 hours)6. postoperative day (every 8 hours)Day of discharge
Levobupivacaine0.60.50.50.3000
Morphine1.41.51.41.41.41.31

Interleukin-6 Concentration in Peripheral Blood.

Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery

,
Interventionpg/ml (Median)
Before surgery24h after surgery72h after surgery
Levobupivacaine26.697.730.5
Morphine27.210450

Perioperative Sleep Efficiency

Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery

Interventionminutes (Mean)
Study: Melatonin20
Control: Placebo-55

Hematocrit (HCT)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventionvolume percentage (vol%) of red blood ce (Median)
Bright Light Therapy28.20
Sham Light26.70

Hemoglobin (HGB)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventiong/dl (Median)
Bright Light Therapy9.70
Sham Light9.55

Hospital Length of Stay

(NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventiondays (Median)
Bright Light Therapy18
Sham Light18.5

Number of Participants Who Developed Delirium Based on Meeting Criteria on the Delirium Rating Scale and/or Memorial Delirium Assessment Scale

Monday, Wednesday, and Friday assessments will begin after beginning light therapy and include the Delirium Rating Scale-Revised-98 (DRS-98)and Memorial Delirium Assessment Scale (MDAS) (NCT01700816)
Timeframe: From hospital admission until the date of first documented delirium, assessed up to 28 days post-transplant

InterventionParticipants (Count of Participants)
Bright Light Therapy1
Sham Light0

Platelet Count

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Interventionthousand cells/uL (Median)
Bright Light Therapy39
Sham Light33.5

Red Blood Cells (RBC)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

InterventionM/uL (Median)
Bright Light Therapy3.21
Sham Light2.93

Severity of Delirium Episodes: Memorial Delirium Assessment Scale (MDAS)

"Monday, Wednesday, and Friday assessments of the Memorial Delirium Assessment Scale (MDAS); Patients will receive assessments after beginning light therapy until day 28 post-transplant or discharge, whichever comes first.~10 item scale Items are rated on a four-point scale from 0 (none) to 3 (severe) depending on the level of impairment, rendering a maximum possible score of 30.~A score of 13 has been recommended as a cut-off for establishing the diagnosis of delirium" (NCT01700816)
Timeframe: From first documented episode of delirium until discharge from the hospital, assessed up to 28 days post-transplant

Interventionunits on a scale (Number)
Bright Light Therapy18

White Blood Cells (WBC)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

InterventionK/uL (Median)
Bright Light Therapy2.30
Sham Light4.75

Serum Creatinine and Blood Urea Nitrogen (BUN)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

,
Interventionmg/dl (Median)
Serum CreatinineBlood Urea Nitrogen (BUN)
Bright Light Therapy0.669
Sham Light0.758.5

Sodium (Na), Potassium (K), Chloride (Cl), and Carbon Dioxide (CO2)

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT (Hematopoietic Stem Cell Transplantation). (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

,
Interventionmmol/L (Median)
Sodium (Na)Potassium (K)Chloride (Cl)Carbon Dioxide (CO2)
Bright Light Therapy1393.610524.9
Sham Light138.03.80103.025.10

Reviews

14 reviews available for melatonin and Postoperative Complications

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
The pharmacotherapeutic management of postoperative delirium: an expert update.
    Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:8

    Topics: Aged; Analgesia; Anesthesia; Antipsychotic Agents; Delirium; Dexmedetomidine; Drug Monitoring; Human

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Melatonin for preoperative and postoperative anxiety in adults.
    The Cochrane database of systematic reviews, 2020, 12-08, Volume: 12

    Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi

2020
Cancer Cachexia: Cause, Diagnosis, and Treatment.
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2017, Volume: 32, Issue:5

    Topics: Anabolic Agents; Animals; Anti-Inflammatory Agents; Appetite Stimulants; Cachexia; Combined Modality

2017
[Surgery and circadian disturbances].
    Ugeskrift for laeger, 2018, Sep-03, Volume: 180, Issue:36

    Topics: Chronobiology Disorders; Circadian Rhythm; Humans; Melatonin; Postoperative Complications; Surgical

2018
The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials.
    Surgical laparoscopy, endoscopy & percutaneous techniques, 2019, Volume: 29, Issue:1

    Topics: Central Nervous System Depressants; Cholecystectomy, Laparoscopic; Depression; Dizziness; Headache D

2019
Pharmacologic prevention of postoperative delirium.
    Zeitschrift fur Gerontologie und Geriatrie, 2014, Volume: 47, Issue:2

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Evidence-Based Medicine; Female; Humans; Hy

2014
[Possibilities of application of melatonin in treatment of patients with surgical diseases].
    Vestnik khirurgii imeni I. I. Grekova, 2015, Volume: 174, Issue:6

    Topics: Antioxidants; Humans; Melatonin; Postoperative Complications; Stress, Physiological; Surgical Proced

2015
Topical non-barrier agents for postoperative adhesion prevention in animal models.
    European journal of obstetrics, gynecology, and reproductive biology, 2010, Volume: 149, Issue:2

    Topics: Acetamides; Antioxidants; Collagen Type I; Female; Fibrin; Glucans; Glucose; Honey; Humans; Hydroxym

2010
Circadian aspects of post-operative morbidity and mortality.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:10

    Topics: Autonomic Nervous System; Circadian Rhythm; Humans; Hydrocortisone; Melatonin; Pharmacokinetics; Pos

2010
Postoperative circadian disturbances.
    Danish medical bulletin, 2010, Volume: 57, Issue:12

    Topics: Body Temperature Regulation; Central Nervous System Depressants; Chronobiology Disorders; Cognition

2010
[Influence of peptides from pineal gland on thymus function at aging].
    Advances in gerontology = Uspekhi gerontologii, 2010, Volume: 23, Issue:4

    Topics: Adjuvants, Immunologic; Aging; Animals; Endocrine Surgical Procedures; Hormone Replacement Therapy;

2010
Postoperative delirium and plasma melatonin.
    Medical hypotheses, 1999, Volume: 53, Issue:2

    Topics: Delirium; Humans; Interferons; Melatonin; Models, Biological; Postoperative Complications; Renal Dia

1999

Trials

15 trials available for melatonin and Postoperative Complications

ArticleYear
Effects of Melatonin on Postoperative Delirium After PCI in Elderly Patients: A Randomized, Single-Center, Double-Blind, Placebo-Controlled Trial.
    The heart surgery forum, 2021, Oct-21, Volume: 24, Issue:5

    Topics: Aged; Coronary Care Units; Delirium; Double-Blind Method; Female; Humans; Incidence; Intention to Tr

2021
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial.
    BMJ open, 2023, 09-11, Volume: 13, Issue:9

    Topics: Cross-Over Studies; Humans; Low Anterior Resection Syndrome; Melatonin; Postoperative Complications;

2023
The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium.
    Journal of the American Geriatrics Society, 2020, Volume: 68, Issue:1

    Topics: Aged; Cardiac Surgical Procedures; Coronary Artery Bypass; Delirium; Double-Blind Method; Female; Hu

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial.
    Iranian journal of medical sciences, 2021, Volume: 46, Issue:2

    Topics: Aged; Coronary Artery Bypass; Delirium; Double-Blind Method; Female; Humans; Iran; Male; Melatonin;

2021
The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial.
    Journal of clinical anesthesia, 2017, Volume: 39

    Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Arthroplasty, Replacement, Hip; China; Circadian Rhythm

2017
Tryptophan supplementation and postoperative delirium--a randomized controlled trial.
    Journal of the American Geriatrics Society, 2014, Volume: 62, Issue:9

    Topics: Aged; Antidepressive Agents, Second-Generation; Delirium; Double-Blind Method; Elective Surgical Pro

2014
Preliminary findings on the effect of melatonin on the clinical outcome of cataract surgery in dogs.
    Veterinary ophthalmology, 2016, Volume: 19, Issue:3

    Topics: Animals; Antioxidants; Cataract Extraction; Dog Diseases; Dogs; Female; Male; Melatonin; Postoperati

2016
The Healthy Heart-Mind trial: melatonin for prevention of delirium following cardiac surgery: study protocol for a randomized controlled trial.
    Trials, 2016, Jan-28, Volume: 17

    Topics: Aged; Cardiac Surgical Procedures; Data Interpretation, Statistical; Delirium; Double-Blind Method;

2016
Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery.
    Anesthesiology, 2009, Volume: 111, Issue:1

    Topics: Adult; Anesthesia; Anesthesia Recovery Period; Anxiety; Child; Child, Preschool; Female; Follow-Up S

2009
Efficacy of melatonin and hyaluronate/carboxymethylcellulose membrane in preventing adhesion reformation following adhesiolysis in a rat uterine model.
    The journal of obstetrics and gynaecology research, 2011, Volume: 37, Issue:2

    Topics: Administration, Topical; Animals; Carboxymethylcellulose Sodium; Combined Modality Therapy; Disease

2011
Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children.
    Journal of anesthesia, 2011, Volume: 25, Issue:2

    Topics: Administration, Oral; Child; Child, Preschool; Dexmedetomidine; Female; Humans; Male; Melatonin; Met

2011
The use of high-dose melatonin in liver resection is safe: first clinical experience.
    Journal of pineal research, 2011, Volume: 50, Issue:4

    Topics: Aged; Antioxidants; Double-Blind Method; Female; Hepatectomy; Humans; Male; Melatonin; Middle Aged;

2011
PORTAL: pilot study on the safety and tolerance of preoperative melatonin application in patients undergoing major liver resection: a double-blind randomized placebo-controlled trial.
    BMC surgery, 2008, Jan-23, Volume: 8

    Topics: Antioxidants; Double-Blind Method; Hepatectomy; Humans; Melatonin; Pilot Projects; Postoperative Com

2008

Other Studies

39 other studies available for melatonin and Postoperative Complications

ArticleYear
Time-related variations in viability of random pattern skin flaps: An experimental study in rats.
    Chronobiology international, 2023, Oct-03, Volume: 40, Issue:10

    Topics: Animals; Antioxidants; Circadian Rhythm; Melatonin; Necrosis; Postoperative Complications; Rats; Ski

2023
Does melatonin addition to indomethacin decrease post endoscopic retrograde cholangiopancreatography pancreatitis? A randomized double-blind controlled trial.
    European journal of gastroenterology & hepatology, 2019, Volume: 31, Issue:11

    Topics: Adult; Aged; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholangiopancreatograp

2019
Relation of serum melatonin levels to postoperative delirium in older patients undergoing major abdominal surgery.
    The Journal of international medical research, 2020, Volume: 48, Issue:3

    Topics: Abdomen; Age Factors; Aged; Biomarkers; Critical Care; Delirium; Female; Humans; Male; Melatonin; Po

2020
Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:2

    Topics: Activity Cycles; Age Factors; Anesthetics, Inhalation; Animals; Circadian Rhythm; Electroencephalogr

2021
Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial.
    BMJ open, 2021, 02-12, Volume: 11, Issue:2

    Topics: Aged; Anesthesia, Conduction; Circadian Rhythm; Delirium; Hip Fractures; Humans; Melatonin; Postoper

2021
Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit.
    Molecules (Basel, Switzerland), 2017, Sep-12, Volume: 22, Issue:9

    Topics: Adolescent; Adult; Aged; C-Reactive Protein; Female; Humans; Inflammation; Inflammation Mediators; I

2017
[Prognostic Value of Melatonin Level, Structural and Functional Changes of the Myocardium in the Development of Complications in Patients With Heart Failure who Underwent Coronary Artery Bypass Grafting: the Possibilities of Pharmacological Cardioprotecti
    Kardiologiia, 2017, Volume: 57, Issue:10

    Topics: Coronary Artery Bypass; Heart Failure; Humans; Melatonin; Myocardium; Postoperative Complications; P

2017
Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice.
    Experimental neurology, 2018, Volume: 306

    Topics: Aging; Anesthetics, Inhalation; Animals; Body Temperature; Circadian Rhythm; CLOCK Proteins; Cogniti

2018
Estimations of Retinal Blue-Light Irradiance Values and Melatonin Suppression Indices Through Clear and Yellow-Tinted Intraocular Lenses.
    Advances in experimental medicine and biology, 2018, Volume: 1074

    Topics: Aphakia, Postcataract; Circadian Rhythm; Color; Fluorescence; Humans; In Vitro Techniques; Lenses, I

2018
Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy.
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:9

    Topics: Adult; Aged; Anesthesia, General; Breast Neoplasms; Fatigue; Female; Humans; Mastectomy, Segmental;

2013
Do fluctuations in endogenous melatonin levels predict the occurrence of postoperative cognitive dysfunction (POCD)?
    The International journal of neuroscience, 2014, Volume: 124, Issue:11

    Topics: Aged; Aged, 80 and over; China; Cognition Disorders; Female; Humans; Incidence; Male; Melatonin; Mid

2014
Sleep-wake and melatonin pattern in craniopharyngioma patients.
    European journal of endocrinology, 2014, Volume: 170, Issue:6

    Topics: Adolescent; Adult; Aged; Circadian Rhythm; Craniopharyngioma; Cross-Sectional Studies; Disorders of

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
Chronobiology, cognitive function and depressive symptoms in surgical patients.
    Danish medical journal, 2014, Volume: 61, Issue:9

    Topics: Adult; Aged; Anxiety; Biomarkers; Breast Neoplasms; Case-Control Studies; Central Nervous System Dep

2014
[ASSESSMENT OF EFFICACY OF MELATONIN IN SURGICAL TREATMENT OF COLON TUMORS].
    Vestnik khirurgii imeni I. I. Grekova, 2015, Volume: 174, Issue:5

    Topics: Aged; Antioxidants; Colonic Neoplasms; Female; Humans; Interleukin-10; Interleukin-1beta; Interleuki

2015
Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Aged; Aged, 80 and over; Circadian Rhythm; Delirium; Female; Hip Fractures; Humans; Male; Melatonin;

2016
Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions.
    Spinal cord, 2009, Volume: 47, Issue:2

    Topics: Analysis of Variance; Animals; Cyclosporine; Disease Models, Animal; Erythropoietin; Female; Locomot

2009
Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma.
    Neurology, 2009, Jul-28, Volume: 73, Issue:4

    Topics: Adolescent; Age Factors; Biomarkers; Circadian Rhythm; Craniopharyngioma; Female; Humans; Hypopituit

2009
A randomised controlled trial on melatonin and rosiglitazone for prevention of adhesion formation in a rat uterine horn model.
    Archives of gynecology and obstetrics, 2010, Volume: 282, Issue:1

    Topics: Administration, Oral; Animals; Antioxidants; Disease Models, Animal; Female; Injections, Intraperito

2010
Melatonin and postoperative delirium: a possible link?
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2010, Volume: 57, Issue:8

    Topics: Alcohol Withdrawal Delirium; Anesthesia Recovery Period; Delayed-Action Preparations; Delirium; Huma

2010
Examination of the effect of melatonin use in Pomeroy method of tubal ligation on ovarian histology in rats.
    Clinical and experimental obstetrics & gynecology, 2012, Volume: 39, Issue:1

    Topics: Animals; Antioxidants; Female; Melatonin; Ovarian Diseases; Ovary; Postoperative Complications; Rats

2012
Melatonin use in unilateral total salpingectomy in rats.
    Clinical and experimental obstetrics & gynecology, 2012, Volume: 39, Issue:2

    Topics: Animals; Antioxidants; Female; Melatonin; Ovary; Postoperative Complications; Rats; Rats, Wistar; Sa

2012
Effect of melatonin in the prevention of post-operative adhesion formation in a rat uterine horn adhesion model.
    Human reproduction (Oxford, England), 2003, Volume: 18, Issue:8

    Topics: Animals; Disease Models, Animal; Female; Free Radical Scavengers; Injections, Intraperitoneal; Melat

2003
Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy.
    Spine, 2003, Sep-01, Volume: 28, Issue:17

    Topics: Animals; Body Weight; Chickens; Light; Melatonin; Pineal Gland; Postoperative Complications; Scolios

2003
Melatonin secretion profile after experimental pineal gland compression in rats.
    Neuro endocrinology letters, 2003, Volume: 24, Issue:6

    Topics: Animals; Circadian Rhythm; Male; Melatonin; Models, Animal; Pineal Gland; Postoperative Complication

2003
Postoperative delirium: the tryptophan dyregulation model.
    Medical hypotheses, 2004, Volume: 63, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Brain; Delirium; Humans; Melatonin; Models, Neurological; Postoperat

2004
Comparison of hyaluronate/carboxymethylcellulose membrane and melatonin for prevention of adhesion formation in a rat model.
    Human reproduction (Oxford, England), 2005, Volume: 20, Issue:7

    Topics: Animals; Carboxymethylcellulose Sodium; Disease Models, Animal; Female; Free Radical Scavengers; Hya

2005
Does anti-oxidant prophylaxis with melatonin prevent adverse outcomes related to increased oxidative stress caused by laparoscopy in experimental rat model?
    The Journal of surgical research, 2006, Volume: 135, Issue:1

    Topics: Animals; Antioxidants; Disease Models, Animal; Intestine, Small; Kidney; Laparoscopy; Liver; Male; M

2006
[Melatonin against surgical stress].
    Ugeskrift for laeger, 2007, Apr-02, Volume: 169, Issue:14

    Topics: Adult; Animals; Antioxidants; Humans; Infant, Newborn; Melatonin; Myocardial Ischemia; Oxidative Str

2007
The effects of melatonin on postoperative intraabdominal adhesion formation.
    Yonsei medical journal, 2007, Aug-31, Volume: 48, Issue:4

    Topics: Abdomen; Animals; Antioxidants; Melatonin; Postoperative Complications; Rats; Rats, Sprague-Dawley;

2007
Exogenous melatonin ameliorates hepatic injury in a rat cardiopulmonary bypass model.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: Animals; Apoptosis; Carbon Dioxide; Cardiopulmonary Bypass; Disease Models, Animal; Dose-Response Re

2008
Circadian rhythm: a new clue for neuropsychological dysfunction after cardiac surgery.
    Chinese medical journal, 2007, Nov-20, Volume: 120, Issue:22

    Topics: Cardiac Surgical Procedures; Circadian Rhythm; Cognition Disorders; Humans; Hydrocortisone; Melatoni

2007
Postoperative neuropsychological change and its underlying mechanism in patients undergoing coronary artery bypass grafting.
    Chinese medical journal, 2007, Nov-20, Volume: 120, Issue:22

    Topics: Cardiopulmonary Bypass; Circadian Rhythm; Cognition Disorders; Coronary Artery Bypass; Humans; Hydro

2007
Pinealectomy and scoliosis.
    The Journal of bone and joint surgery. American volume, 2000, Volume: 82, Issue:8

    Topics: Animals; Chickens; Melatonin; Pineal Gland; Postoperative Complications; Scoliosis; Time Factors

2000
Melatonin secretion after surgery.
    Lancet (London, England), 2000, Oct-07, Volume: 356, Issue:9237

    Topics: Adult; Circadian Rhythm; Female; Humans; Hysterectomy; Melatonin; Middle Aged; Postoperative Complic

2000
[The role of melatonin in the immediate postoperative period in elderly patients].
    Minerva chirurgica, 2000, Volume: 55, Issue:11

    Topics: Aged; Aged, 80 and over; Female; Humans; Male; Melatonin; Middle Aged; Neoplasms; Postoperative Comp

2000
Postoperative delirium, plasma melatonin, and light.
    Medical hypotheses, 2001, Volume: 56, Issue:3

    Topics: Circadian Rhythm; Delirium; Humans; Light; Melatonin; Postoperative Complications

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Postoperative delirium and melatonin levels in elderly patients.
    American journal of surgery, 2001, Volume: 182, Issue:5

    Topics: Abdomen; Aged; Aged, 80 and over; Delirium; Female; Humans; Male; Melatonin; Postoperative Complicat

2001
Melatonin for treatment and prevention of postoperative delirium.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:2

    Topics: Aged; Delirium; Humans; Male; Melatonin; Middle Aged; Postoperative Complications

2002
[Pathogenesis and diagnosis of dysovarian cardiomyopathy].
    Terapevticheskii arkhiv, 1986, Volume: 58, Issue:11

    Topics: Adult; Cardiomyopathies; Climacteric; Electrolytes; Estradiol; Female; Gonadotropins, Pituitary; Hum

1986