melatonin has been researched along with Post-Concussion Symptoms in 8 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although children with persistent post-concussion symptoms reported more SRPs, this was not related to actigraphy sleep parameters or melatonin production." | 7.96 | Sleep Parameters and Overnight Urinary Melatonin Production in Children With Persistent Post-concussion Symptoms. ( Barlow, KM; Crowe, EG; Dewey, D; Esser, MJ; Girgulis, KA; Goldstein, G; Kirk, VG; Su, P; Vo, MK, 2020) |
| "Melatonin treatment is often recommended, yet supporting evidence is scarce." | 7.01 | Efficacy of Melatonin for Sleep Disturbance in Children with Persistent Post-Concussion Symptoms: Secondary Analysis of a Randomized Controlled Trial. ( Barlow, KM; Boyd, R; Brooks, B; Cameron, C; Dewey, D; Esser, MJ; Hill, M; Hutchison, J; Kirk, V; Kirton, A; MacMaster, F; Mikrogianakis, A; Nettel-Aguirre, A; Turley, B; Yeates, KO; Zemek, R, 2021) |
| "Melatonin is a safe and well-tolerated agent that has many biological properties that may be useful following a traumatic brain injury." | 6.79 | A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial. ( Angelo, M; Barlow, KM; Brooks, BL; Buchhalter, J; Crawford, S; Dewey, D; Emery, CA; Esser, M; Hill, MD; Hutchison, J; Johnson, D; Kirk, V; Kirton, A; MacMaster, FP; Nettel-Aguirre, A; Platt, R; Richer, L; Seeger, T; Turley, B; Zemek, R, 2014) |
| " Common PPCS complaints such as sleep disturbance and fatigue could be ameliorated via the supplementation of melatonin, which has significant neuroprotective and anti-inflammatory properties." | 5.34 | Neural Correlates of Sleep Recovery following Melatonin Treatment for Pediatric Concussion: A Randomized Controlled Trial. ( Barlow, KM; Cocchi, L; Iyer, KK; Zalesky, A, 2020) |
| "Although children with persistent post-concussion symptoms reported more SRPs, this was not related to actigraphy sleep parameters or melatonin production." | 3.96 | Sleep Parameters and Overnight Urinary Melatonin Production in Children With Persistent Post-concussion Symptoms. ( Barlow, KM; Crowe, EG; Dewey, D; Esser, MJ; Girgulis, KA; Goldstein, G; Kirk, VG; Su, P; Vo, MK, 2020) |
| "Melatonin treatment is often recommended, yet supporting evidence is scarce." | 3.01 | Efficacy of Melatonin for Sleep Disturbance in Children with Persistent Post-Concussion Symptoms: Secondary Analysis of a Randomized Controlled Trial. ( Barlow, KM; Boyd, R; Brooks, B; Cameron, C; Dewey, D; Esser, MJ; Hill, M; Hutchison, J; Kirk, V; Kirton, A; MacMaster, F; Mikrogianakis, A; Nettel-Aguirre, A; Turley, B; Yeates, KO; Zemek, R, 2021) |
| "Melatonin has significant neuroprotective properties, and promising preclinical data suggest its potential to improve outcomes after traumatic brain injury." | 2.94 | Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial. ( Barlow, KM; Boyd, R; Brooks, BL; Buchhalter, J; Cameron, C; Crawford, S; Dewey, D; Esser, MJ; Hill, MD; Hutchison, JS; Kirk, V; Kirton, A; MacMaster, FP; Mikrogianakis, A; Nettel-Aguirre, A; Platt, R; Richer, L; Samuel, T; Turley, B; Yeates, KO; Zemek, RL, 2020) |
| "Melatonin is a safe and well-tolerated agent that has many biological properties that may be useful following a traumatic brain injury." | 2.79 | A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial. ( Angelo, M; Barlow, KM; Brooks, BL; Buchhalter, J; Crawford, S; Dewey, D; Emery, CA; Esser, M; Hill, MD; Hutchison, J; Johnson, D; Kirk, V; Kirton, A; MacMaster, FP; Nettel-Aguirre, A; Platt, R; Richer, L; Seeger, T; Turley, B; Zemek, R, 2014) |
| "Melatonin prescription was not associated with faster symptom recovery." | 1.62 | Sleep Problems and Melatonin Prescription After Concussion Among Youth Athletes. ( Howell, DR; Kirkwood, MW; Potter, MN; Provance, AJ; Wilson, JC; Wilson, PE, 2021) |
| "Melatonin was able to restore baseline function for control and enriched animals, but was ineffective for the stress condition." | 1.46 | Manipulating cognitive reserve: Pre-injury environmental conditions influence the severity of concussion symptomology, gene expression, and response to melatonin treatment in rats. ( Barlow, KM; Brooks, BL; Esser, MJ; Mychasiuk, R; Salberg, S; Yamakawa, GR; Yeates, KO, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 6 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Feinberg, C | 1 |
| Dickerson Mayes, K | 1 |
| Jarvis, RC | 1 |
| Carr, C | 1 |
| Mannix, R | 1 |
| Barlow, KM | 6 |
| Girgulis, KA | 1 |
| Goldstein, G | 1 |
| Crowe, EG | 1 |
| Vo, MK | 1 |
| Su, P | 1 |
| Esser, MJ | 4 |
| Dewey, D | 4 |
| Kirk, VG | 1 |
| Brooks, BL | 3 |
| Kirton, A | 3 |
| Mikrogianakis, A | 2 |
| Zemek, RL | 1 |
| MacMaster, FP | 2 |
| Nettel-Aguirre, A | 3 |
| Yeates, KO | 3 |
| Kirk, V | 3 |
| Hutchison, JS | 1 |
| Crawford, S | 2 |
| Turley, B | 3 |
| Cameron, C | 2 |
| Hill, MD | 2 |
| Samuel, T | 1 |
| Buchhalter, J | 2 |
| Richer, L | 2 |
| Platt, R | 2 |
| Boyd, R | 2 |
| Iyer, KK | 1 |
| Zalesky, A | 1 |
| Cocchi, L | 1 |
| Brooks, B | 1 |
| Zemek, R | 2 |
| MacMaster, F | 1 |
| Hutchison, J | 2 |
| Hill, M | 1 |
| Howell, DR | 1 |
| Potter, MN | 1 |
| Provance, AJ | 1 |
| Wilson, PE | 1 |
| Kirkwood, MW | 1 |
| Wilson, JC | 1 |
| Yamakawa, GR | 1 |
| Salberg, S | 1 |
| Mychasiuk, R | 1 |
| Seeger, T | 1 |
| Esser, M | 1 |
| Angelo, M | 1 |
| Emery, CA | 1 |
| Johnson, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PLAY GAME: Post-concussion Syndrome Affecting Youth: GABAergic Effects of Melatonin. A Randomized Double-blind Placebo-controlled Trial of MELATONIN[NCT01874847] | Phase 2/Phase 3 | 99 participants (Actual) | Interventional | 2013-09-30 | Active, not recruiting | ||
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| The Effectiveness of Melatonin for the Treatment of Acute Pediatric Concussion[NCT04731974] | Phase 2 | 254 participants (Anticipated) | Interventional | 2023-03-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for melatonin and Post-Concussion Symptoms
| Article | Year |
|---|---|
Nutritional Supplement and Dietary Interventions as a Prophylaxis or Treatment of Sub-Concussive Repetitive Head Impact and Mild Traumatic Brain Injury: A Systematic Review.
Topics: Brain Concussion; Dietary Supplements; Humans; Melatonin; Observational Studies as Topic; Post-Concu | 2023 |
4 trials available for melatonin and Post-Concussion Symptoms
| Article | Year |
|---|---|
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.
Topics: Adolescent; Brain Concussion; Child; Cognition; Confidence Intervals; Double-Blind Method; Female; H | 2020 |
Neural Correlates of Sleep Recovery following Melatonin Treatment for Pediatric Concussion: A Randomized Controlled Trial.
Topics: Adolescent; Brain; Central Nervous System Depressants; Child; Double-Blind Method; Fatigue; Female; | 2020 |
Efficacy of Melatonin for Sleep Disturbance in Children with Persistent Post-Concussion Symptoms: Secondary Analysis of a Randomized Controlled Trial.
Topics: Actigraphy; Adolescent; Antioxidants; Child; Double-Blind Method; Female; Humans; Male; Melatonin; P | 2021 |
A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial.
Topics: Administration, Sublingual; Adolescent; Clinical Protocols; Double-Blind Method; Humans; Melatonin; | 2014 |
3 other studies available for melatonin and Post-Concussion Symptoms
| Article | Year |
|---|---|
Sleep Parameters and Overnight Urinary Melatonin Production in Children With Persistent Post-concussion Symptoms.
Topics: Actigraphy; Adolescent; Child; Female; Humans; Male; Melatonin; Post-Concussion Syndrome; Prospectiv | 2020 |
Sleep Problems and Melatonin Prescription After Concussion Among Youth Athletes.
Topics: Adolescent; Athletes; Athletic Injuries; Brain Concussion; Child; Female; Humans; Male; Melatonin; P | 2021 |
Manipulating cognitive reserve: Pre-injury environmental conditions influence the severity of concussion symptomology, gene expression, and response to melatonin treatment in rats.
Topics: Animals; Antioxidants; Behavior, Animal; Brain Concussion; Cognitive Reserve; Environment; Epigenesi | 2017 |