Page last updated: 2024-10-19

melatonin and Pneumonia

melatonin has been researched along with Pneumonia in 13 studies

Pneumonia: Infection of the lung often accompanied by inflammation.

Research Excerpts

ExcerptRelevanceReference
"pneumoniae-induced inflammation is necessary for the survival of patients."5.72Melatonin ameliorates lung cell inflammation and apoptosis caused by Klebsiella pneumoniae via AMP-activated protein kinase. ( Jiang, W; Liu, J; Yang, W; Zhao, X, 2022)
"The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs."3.85Original research paper. Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats. ( Al-Rasheed, NM; Attia, HA; Fadda, L; Mohamed, AM; Sharaf, IA, 2017)
"The etiology of neonatal lung injury is complicated."2.82[Research progress on antioxidant mechanism of melatonin in reducing neonatal lung injury]. ( Chen, L; Zhang, Y, 2022)
"pneumoniae-induced inflammation is necessary for the survival of patients."1.72Melatonin ameliorates lung cell inflammation and apoptosis caused by Klebsiella pneumoniae via AMP-activated protein kinase. ( Jiang, W; Liu, J; Yang, W; Zhao, X, 2022)
"But melatonin treatment was found more efficient than SMT treatment."1.39The protective effect of melatonin and S-methylisothiourea treatments in nitrogen mustard induced lung toxicity in rats. ( Aydin, I; Kenar, L; Korkmaz, A; Kunak, ZI; Macit, E; Onguru, O; Turel, S; Uysal, B; Yaman, H; Yaren, H, 2013)
"We recently showed that sleep deprivation (SD) exacerbates existing acute lung inflammation, and that melatonin treatment attenuates it via anti-apoptotic and anti-oxidant action."1.38Melatonin improves inflammatory cytokine profiles in lung inflammation associated with sleep deprivation. ( Baik, HW; Jo, KJ; Kim, BJ; Kim, DH; Kim, JY; Kim, SP; Lee, KH; Lee, SK; Lee, YD, 2012)
"Oral melatonin treatment indicated anti-inflammatory efficacy as evidenced by decreased methacholine sensitivity by 24% and airway obstruction by 28%, reduction in BAL eosinophil (P < 0."1.37Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats. ( Chen, CF; Reiter, RJ; Wang, D; Yeh, DY, 2011)
"The malondialdehyde (MDA) level was determined for the effect of oxidative stress."1.35Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice. ( Baik, HW; Baik, TK; Kim, BJ; Kim, JY; Kim, OS; Kwak, YJ; Lee, JH; Lee, KH; Lee, SK; Lee, YD; Song, DY, 2009)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's6 (46.15)24.3611
2020's6 (46.15)2.80

Authors

AuthorsStudies
Liu, X1
Zhang, Y2
Ren, Y1
Li, J1
Chen, L1
Jiang, W1
Liu, J1
Zhao, X1
Yang, W1
Niu, Z1
Li, R1
Mao, K1
Luo, P1
Geng, W1
Xu, J1
Liao, Y1
Zhong, H1
Ma, P1
Tan, Q1
Xia, H1
Duan, L1
Song, S1
Long, D1
Liu, Y1
Yang, T1
Wu, Y1
Jin, Y1
Sheikholeslami, S1
Aryafar, T1
Abedi-Firouzjah, R1
Banaei, A1
Dorri-Giv, M1
Zamani, H1
Ataei, G1
Majdaeen, M1
Farhood, B1
Macit, E1
Yaren, H1
Aydin, I1
Kunak, ZI1
Yaman, H1
Onguru, O1
Uysal, B1
Korkmaz, A1
Turel, S1
Kenar, L1
Taslidere, E1
Esrefoglu, M1
Elbe, H1
Cetin, A1
Ates, B1
Wu, HM1
Shen, QY1
Fang, L1
Zhang, SH1
Shen, PT1
Liu, YJ1
Liu, RY1
Al-Rasheed, NM2
Fadda, L1
Attia, HA1
Sharaf, IA1
Mohamed, AM1
Lee, YD2
Kim, JY3
Lee, KH2
Kwak, YJ1
Lee, SK2
Kim, OS1
Song, DY1
Lee, JH1
Baik, TK1
Kim, BJ2
Baik, HW2
Chen, CF1
Wang, D1
Reiter, RJ1
Yeh, DY1
Kim, SP1
Kim, DH1
Jo, KJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754]Phase 20 participants (Actual)Interventional2021-04-01Withdrawn (stopped due to lack of subject enrollment)
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483]Phase 28 participants (Actual)Interventional2020-11-06Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for melatonin and Pneumonia

ArticleYear
[Research progress on antioxidant mechanism of melatonin in reducing neonatal lung injury].
    Zhonghua wei zhong bing ji jiu yi xue, 2022, Volume: 34, Issue:2

    Topics: Antioxidants; Humans; Infant, Newborn; Lung; Lung Injury; Melatonin; Oxidative Stress; Pneumonia

2022
The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review.
    Life sciences, 2021, Sep-15, Volume: 281

    Topics: Animals; Humans; Lung; Lung Neoplasms; Melatonin; Pneumonia; Pulmonary Fibrosis; Radiation Injuries;

2021

Other Studies

11 other studies available for melatonin and Pneumonia

ArticleYear
Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice.
    Bioscience reports, 2021, 09-30, Volume: 41, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal;

2021
Melatonin ameliorates lung cell inflammation and apoptosis caused by Klebsiella pneumoniae via AMP-activated protein kinase.
    Inflammopharmacology, 2022, Volume: 30, Issue:6

    Topics: AMP-Activated Protein Kinases; Apoptosis; Humans; Inflammation; Klebsiella Infections; Klebsiella pn

2022
Clinical study of novel coronavirus pneumonia prevention by melatonin.
    Reproductive biomedicine online, 2020, Volume: 41, Issue:6

    Topics: COVID-19; Humans; Melatonin; Pandemics; Pneumonia; Reproductive Health; SARS-CoV-2

2020
An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Biomarkers; Case-Control Studies; Disease Models, Animal; Disease Progression; Female; Gene

2021
The protective effect of melatonin and S-methylisothiourea treatments in nitrogen mustard induced lung toxicity in rats.
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:3

    Topics: Animals; Chemical Warfare Agents; Interleukin-1beta; Isothiuronium; Lung; Lung Diseases; Male; Mechl

2013
Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.
    Experimental lung research, 2014, Volume: 40, Issue:2

    Topics: Acute Lung Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Fe

2014
JNK-TLR9 signal pathway mediates allergic airway inflammation through suppressing melatonin biosynthesis.
    Journal of pineal research, 2016, Volume: 60, Issue:4

    Topics: Animals; Asthma; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Femal

2016
Original research paper. Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats.
    Acta pharmaceutica (Zagreb, Croatia), 2017, Mar-01, Volume: 67, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Carrier Proteins; Cytoprotection; Disease Models, Animal; Drug Th

2017
Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice.
    Journal of pineal research, 2009, Volume: 46, Issue:1

    Topics: Analysis of Variance; Animals; Body Weight; Histocytochemistry; In Situ Nick-End Labeling; Lipid Per

2009
Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats.
    Journal of pineal research, 2011, Volume: 50, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Animals; Bronchoalveolar Lavage; Chromatography, H

2011
Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats.
    Journal of pineal research, 2011, Volume: 50, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Animals; Bronchoalveolar Lavage; Chromatography, H

2011
Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats.
    Journal of pineal research, 2011, Volume: 50, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Animals; Bronchoalveolar Lavage; Chromatography, H

2011
Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats.
    Journal of pineal research, 2011, Volume: 50, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Animals; Bronchoalveolar Lavage; Chromatography, H

2011
Melatonin improves inflammatory cytokine profiles in lung inflammation associated with sleep deprivation.
    Molecular medicine reports, 2012, Volume: 5, Issue:5

    Topics: Animals; Bronchoalveolar Lavage; Central Nervous System Depressants; Cytokines; Humans; Lipopolysacc

2012
Melatonin improves inflammatory cytokine profiles in lung inflammation associated with sleep deprivation.
    Molecular medicine reports, 2012, Volume: 5, Issue:5

    Topics: Animals; Bronchoalveolar Lavage; Central Nervous System Depressants; Cytokines; Humans; Lipopolysacc

2012
Melatonin improves inflammatory cytokine profiles in lung inflammation associated with sleep deprivation.
    Molecular medicine reports, 2012, Volume: 5, Issue:5

    Topics: Animals; Bronchoalveolar Lavage; Central Nervous System Depressants; Cytokines; Humans; Lipopolysacc

2012
Melatonin improves inflammatory cytokine profiles in lung inflammation associated with sleep deprivation.
    Molecular medicine reports, 2012, Volume: 5, Issue:5

    Topics: Animals; Bronchoalveolar Lavage; Central Nervous System Depressants; Cytokines; Humans; Lipopolysacc

2012