melatonin has been researched along with Pervasive Child Development Disorders in 26 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 15 patients with disappearing effectiveness of melatonin, seven were diagnosed with autism spectrum disorder, and in four of them a SNP was found." | 7.79 | CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder? ( Braam, W; Curfs, L; Didden, R; Keijzer, H; Smits, M; Struijker Boudier, H, 2013) |
| "Of 15 patients with disappearing effectiveness of melatonin, seven were diagnosed with autism spectrum disorder, and in four of them a SNP was found." | 3.79 | CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder? ( Braam, W; Curfs, L; Didden, R; Keijzer, H; Smits, M; Struijker Boudier, H, 2013) |
| "Melatonin treatment was mainly effective in reducing insomnia symptoms, while cognitive-behavioural therapy had a light positive impact mainly on sleep latency, suggesting that some behavioural aspects might play a role in determining initial insomnia." | 2.77 | Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. ( Cortesi, F; Giannotti, F; Panunzi, S; Sebastiani, T; Valente, D, 2012) |
| "Melatonin is an endogenous neurohormone produced predominantly in the pineal gland." | 2.50 | Melatonin in autism spectrum disorders. ( Frye, RE; Rossignol, DA, 2014) |
| "Identifying and treating sleep disorders may result not only in improved sleep, but also impact favorably on daytime behavior and family functioning." | 2.46 | Sleep in children with autistic spectrum disorder. ( Cortesi, F; Giannotti, F; Ivanenko, A; Johnson, K, 2010) |
| " In endogenous samples, maximal melatonin concentration (C(max)) and time to peak concentration (T(max)) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children." | 1.40 | Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep. ( Adkins, KW; Burgess, HJ; Calcutt, MW; Carter, MD; Goldman, SE; Goodpaster, RL; Hachey, DL; Malow, BA; Shi, Y; Wang, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 24 (92.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Whitehouse, AJ | 1 |
| Hendren, RL | 1 |
| Mori, K | 1 |
| Rossignol, DA | 2 |
| Frye, RE | 2 |
| Grigg-Damberger, M | 1 |
| Ralls, F | 1 |
| Tordjman, S | 1 |
| Najjar, I | 1 |
| Bellissant, E | 1 |
| Anderson, GM | 1 |
| Barburoth, M | 1 |
| Cohen, D | 1 |
| Jaafari, N | 1 |
| Schischmanoff, O | 1 |
| Fagard, R | 1 |
| Lagdas, E | 1 |
| Kermarrec, S | 1 |
| Ribardiere, S | 1 |
| Botbol, M | 1 |
| Fougerou, C | 1 |
| Bronsard, G | 1 |
| Vernay-Leconte, J | 1 |
| Damiani, JM | 1 |
| Sweet, BV | 1 |
| Sohoni, P | 1 |
| Takumi, T | 1 |
| Goldman, SE | 1 |
| Adkins, KW | 1 |
| Calcutt, MW | 1 |
| Carter, MD | 1 |
| Goodpaster, RL | 1 |
| Wang, L | 1 |
| Shi, Y | 1 |
| Burgess, HJ | 1 |
| Hachey, DL | 1 |
| Malow, BA | 2 |
| Veatch, OJ | 1 |
| Pendergast, JS | 1 |
| Allen, MJ | 1 |
| Leu, RM | 1 |
| Johnson, CH | 1 |
| Elsea, SH | 1 |
| Pagan, C | 1 |
| Delorme, R | 1 |
| Callebert, J | 1 |
| Goubran-Botros, H | 1 |
| Amsellem, F | 1 |
| Drouot, X | 1 |
| Boudebesse, C | 1 |
| Le Dudal, K | 1 |
| Ngo-Nguyen, N | 1 |
| Laouamri, H | 1 |
| Gillberg, C | 1 |
| Leboyer, M | 1 |
| Bourgeron, T | 1 |
| Launay, JM | 1 |
| Brandt Andersen, J | 1 |
| Jennum, P | 1 |
| Braam, W | 2 |
| Smits, MG | 1 |
| Didden, R | 2 |
| Korzilius, H | 1 |
| Van Geijlswijk, IM | 1 |
| Curfs, LM | 1 |
| Jonsson, L | 1 |
| Ljunggren, E | 1 |
| Bremer, A | 1 |
| Pedersen, C | 1 |
| Landén, M | 1 |
| Thuresson, K | 1 |
| Giacobini, M | 1 |
| Melke, J | 1 |
| Wright, B | 1 |
| Sims, D | 1 |
| Smart, S | 1 |
| Alwazeer, A | 1 |
| Alderson-Day, B | 1 |
| Allgar, V | 1 |
| Whitton, C | 1 |
| Tomlinson, H | 1 |
| Bennett, S | 1 |
| Jardine, J | 1 |
| McCaffrey, N | 1 |
| Leyland, C | 1 |
| Jakeman, C | 1 |
| Miles, J | 1 |
| Cortesi, F | 2 |
| Giannotti, F | 2 |
| Ivanenko, A | 1 |
| Johnson, K | 1 |
| Guénolé, F | 4 |
| Baleyte, JM | 4 |
| Doyen, C | 1 |
| Mighiu, D | 1 |
| Kaye, K | 1 |
| Colineaux, C | 1 |
| Beaumanoir, C | 1 |
| Mouraeff, Y | 1 |
| Rieu, C | 1 |
| Paubel, P | 1 |
| Contejean, Y | 1 |
| Godbout, R | 1 |
| Nicolas, A | 1 |
| Franco, P | 1 |
| Claustrat, B | 1 |
| Sherk, Y | 1 |
| Smith, BA | 1 |
| Miller, BD | 1 |
| Sebastiani, T | 1 |
| Panunzi, S | 1 |
| Valente, D | 1 |
| Keijzer, H | 1 |
| Struijker Boudier, H | 1 |
| Smits, M | 1 |
| Curfs, L | 1 |
| Wasdell, MB | 1 |
| Jan, JE | 1 |
| Bomben, MM | 1 |
| Freeman, RD | 1 |
| Rietveld, WJ | 1 |
| Tai, J | 1 |
| Hamilton, D | 1 |
| Weiss, MD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Controlled-Release Melatonin (Melatonin CR)for the Treatment of Impaired Sleep Maintenance (ISM) in 4-8 Year Old Children With Autism Spectrum Disorders (ASD).[NCT01033565] | Phase 4 | 1 participants (Actual) | Interventional | 2010-03-04 | Terminated (stopped due to Unsuccessful in recruiting appropriate subjects.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Assigns numerical score indicating level of improvement compared to baseline. Scale is rated from 1-7: 1= very much improved; 2= much improved; 3= minimally improved; 4= no change; 5= minimally worse; 6= much worse; 7= very much worse. (NCT01033565)
Timeframe: 2 weeks
| Intervention | units on a scale (Number) |
|---|---|
| Natrol | 2 |
13 reviews available for melatonin and Pervasive Child Development Disorders
| Article | Year |
|---|---|
Complementary and alternative medicine for autism spectrum disorders: rationale, safety and efficacy.
Topics: Central Nervous System Depressants; Child; Child Development Disorders, Pervasive; Complementary The | 2013 |
Autism: biomedical complementary treatment approaches.
Topics: Acetylcysteine; Central Nervous System Depressants; Chelation Therapy; Child; Child Development Diso | 2013 |
[Psychopharmacological interventions in autism spectrum disorders].
Topics: Child; Child Development Disorders, Pervasive; Dopamine; Epilepsy; gamma-Aminobutyric Acid; Humans; | 2010 |
Melatonin in autism spectrum disorders.
Topics: Animals; Child; Child Development Disorders, Pervasive; Circadian Rhythm; Humans; Melatonin; Sleep; | 2014 |
Treatment strategies for complex behavioral insomnia in children with neurodevelopmental disorders.
Topics: Angelman Syndrome; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2013 |
Advances in the research of melatonin in autism spectrum disorders: literature review and new perspectives.
Topics: Animals; Child Development Disorders, Pervasive; Communication Disorders; Humans; Melatonin | 2013 |
Melatonin: an option for managing sleep disorders in children with autism spectrum disorder.
Topics: Adolescent; Chemistry, Pharmaceutical; Child; Child Development Disorders, Pervasive; Child, Prescho | 2014 |
[Autism spectrum disorders].
Topics: Child Development Disorders, Pervasive; Circadian Rhythm; Humans; Melatonin; Sleep Wake Disorders; W | 2013 |
Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis.
Topics: Angelman Syndrome; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2009 |
Sleep in children with autistic spectrum disorder.
Topics: Child; Child Development Disorders, Pervasive; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2010 |
Melatonin in children with autistic spectrum disorders: recent and practical data.
Topics: Child; Child Development Disorders, Pervasive; Humans; Melatonin; Sleep Wake Disorders | 2011 |
Melatonin for disordered sleep in individuals with autism spectrum disorders: systematic review and discussion.
Topics: Adolescent; Adult; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive | 2011 |
Melatonin in autism spectrum disorders: a systematic review and meta-analysis.
Topics: Child; Child Development Disorders, Pervasive; Child, Preschool; Databases, Factual; Double-Blind Me | 2011 |
3 trials available for melatonin and Pervasive Child Development Disorders
10 other studies available for melatonin and Pervasive Child Development Disorders
| Article | Year |
|---|---|
Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep.
Topics: Child; Child Development Disorders, Pervasive; Child, Preschool; Female; Humans; Male; Melatonin; Po | 2014 |
Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.
Topics: Acetylserotonin O-Methyltransferase; Child; Child Development Disorders, Pervasive; Child, Preschool | 2015 |
The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders.
Topics: Adolescent; Adult; Biomarkers; Child; Child Development Disorders, Pervasive; Female; Humans; Male; | 2014 |
[Troubling increase in consumption of the sleeping drug melatonin for children].
Topics: Adolescent; Central Nervous System Depressants; Child; Child Development Disorders, Pervasive; Drug | 2013 |
Mutation screening of melatonin-related genes in patients with autism spectrum disorders.
Topics: Amino Acid Sequence; Child; Child Development Disorders, Pervasive; Cohort Studies; Conserved Sequen | 2010 |
Effectiveness of melatonin for sleep problems in autism spectrum disorders: evidence grows but research is still needed.
Topics: Central Nervous System Depressants; Child Development Disorders, Pervasive; Female; Humans; Male; Me | 2011 |
Liquid melatonin via gastrostomy as an alternative hypnotic in a child with pervasive developmental disorder.
Topics: Central Nervous System Depressants; Child Development Disorders, Pervasive; Child, Preschool; Gastro | 2011 |
Melatonin for sleep-disturbed children with autism spectrum disorders: can we really speak of a substitution treatment?
Topics: Child Development Disorders, Pervasive; Humans; Melatonin; Sleep Wake Disorders | 2011 |
Meta-analysing the effectiveness of melatonin for sleep-disturbed individuals with autism spectrum conditions: should Rett syndrome be included?
Topics: Child Development Disorders, Pervasive; Humans; Melatonin | 2011 |
CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder?
Topics: Adolescent; Adult; Autistic Disorder; Child; Child Development Disorders, Pervasive; Child, Preschoo | 2013 |