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melatonin and Peripheral Nerve Injury

melatonin has been researched along with Peripheral Nerve Injury in 14 studies

Research Excerpts

ExcerptRelevanceReference
"With its neuroprotective effect, as demonstrated in this experimental peripheral nerve injury, melatonin might be used successfully in clinical practice."7.75Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study. ( Biyikli, Z; Daglioglu, E; Erdogan, D; Ergungor, F; Kilinc, K; Okay, O; Serdar Dike, M; Take, G, 2009)
"The aim of this study was to determine the curative effects of high-dose (100 mg/kg) melatonin on peripheral nerve injury."3.96Electrophysiological, functional and histopathological assessments of high dose melatonin on regeneration after blunt sciatic nerve injury. ( Baykal, S; Boz, C; Çakır, E; Çobanoğlu, Ü; Yazar, U, 2020)
"The main aim of this study was to research new treatments following peripheral nerve injury involving melatonin (Mel), acetyl-l-carnitine (ALCAR), and leptin (Lep) using updated unbiased methods at the stereological and electron microscopic levels."3.85Possible effects of some agents on the injured nerve in obese rats: A stereological and electron microscopic study. ( Altun, G; Altunkaynak, BZ; Geuna, S; Kaplan, S; Muratori, L; Onger, ME; Türkmen, AP, 2017)
"With its neuroprotective effect, as demonstrated in this experimental peripheral nerve injury, melatonin might be used successfully in clinical practice."3.75Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study. ( Biyikli, Z; Daglioglu, E; Erdogan, D; Ergungor, F; Kilinc, K; Okay, O; Serdar Dike, M; Take, G, 2009)
"Melatonin is a widely distributed and important signal molecule that occurs in unicellular organisms, plants, and fungi in addition to animals and humans."2.45Chapter 16: Melatonin and nerve regeneration. ( Kaplan, S; Odaci, E, 2009)
"A mouse model of chronic neuropathic pain induced by partial sciatic nerve ligation (PSL) was employed."1.40Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. ( Chen, CR; Chen, L; Cheng, NN; Huang, ZL; Laudon, M; Liu, YY; Qu, WM; Urade, Y; Yin, D, 2014)
"Melatonin treatments increased the SFI values in the injured sciatic nerves."1.36Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury. ( Bilgin, MD; Yaraneri, H; Zencirci, SG, 2010)
"Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior."1.35Exacerbated mechanical allodynia in rats with depression-like behavior. ( Chang, Y; Guo, G; Lim, G; Lim, JA; Mao, J; Sung, B; Wang, S; Yang, L; Zeng, Q, 2008)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (28.57)29.6817
2010's6 (42.86)24.3611
2020's4 (28.57)2.80

Authors

AuthorsStudies
Yon, DK1
Kim, YJ1
Park, DC1
Jung, SY1
Kim, SS1
Yeo, JH1
Lee, J1
Lee, JM1
Yeo, SG1
Yazar, U1
Çakır, E1
Boz, C1
Çobanoğlu, Ü1
Baykal, S1
Stazi, M1
Negro, S1
Megighian, A1
D'Este, G1
Solimena, M1
Jockers, R1
Lista, F1
Montecucco, C1
Rigoni, M1
Pan, B1
Jing, L1
Cao, M1
Hu, Y1
Gao, X1
Bu, X1
Li, Z1
Feng, H1
Guo, K1
Onger, ME1
Kaplan, S3
Geuna, S1
Türkmen, AP1
Muratori, L1
Altun, G1
Altunkaynak, BZ1
Chang, HM2
Liu, CH1
Hsu, WM1
Chen, LY1
Wang, HP1
Wu, TH1
Chen, KY1
Ho, WH1
Liao, WC1
Liu, YY1
Yin, D1
Chen, L1
Qu, WM1
Chen, CR1
Laudon, M1
Cheng, NN1
Urade, Y1
Huang, ZL1
Mekaj, AY1
Morina, AA1
Bytyqi, CI1
Mekaj, YH1
Duci, SB1
Odaci, E1
Daglioglu, E1
Serdar Dike, M1
Kilinc, K1
Erdogan, D1
Take, G1
Ergungor, F1
Okay, O1
Biyikli, Z1
Zencirci, SG1
Bilgin, MD1
Yaraneri, H1
Turgut, M1
Zeng, Q1
Wang, S1
Lim, G1
Yang, L1
Mao, J2
Sung, B1
Chang, Y1
Lim, JA1
Guo, G1
Ling, EA1
Lue, JH1
Wen, CY1
Shieh, JY1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432]Phase 240 participants (Anticipated)Interventional2016-06-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for melatonin and Peripheral Nerve Injury

ArticleYear
Induction of Autophagy and Its Role in Peripheral Nerve Regeneration after Peripheral Nerve Injury.
    International journal of molecular sciences, 2023, Nov-11, Volume: 24, Issue:22

    Topics: Animals; Autophagy; Melatonin; Mice; Nerve Regeneration; Peripheral Nerve Injuries; Peripheral Nerve

2023
Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process.
    Journal of orthopaedic surgery and research, 2014, Oct-11, Volume: 9

    Topics: Adjuvants, Immunologic; Administration, Cutaneous; Antioxidants; Humans; Hyaluronic Acid; Immunosupp

2014
Chapter 16: Melatonin and nerve regeneration.
    International review of neurobiology, 2009, Volume: 87

    Topics: Animals; Humans; Melatonin; Nerve Regeneration; Optic Nerve; Pain; Peripheral Nerve Injuries; Periph

2009
Effects of melatonin on peripheral nerve regeneration.
    Recent patents on endocrine, metabolic & immune drug discovery, 2011, Volume: 5, Issue:2

    Topics: Animals; Antioxidants; Chickens; Melatonin; Nerve Regeneration; Peripheral Nerve Injuries; Rats

2011

Other Studies

10 other studies available for melatonin and Peripheral Nerve Injury

ArticleYear
Electrophysiological, functional and histopathological assessments of high dose melatonin on regeneration after blunt sciatic nerve injury.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2020, Volume: 72

    Topics: Animals; Axons; Male; Melatonin; Myelin Sheath; Nerve Regeneration; Peripheral Nerve Injuries; Rats;

2020
Melatonin promotes regeneration of injured motor axons via MT
    Journal of pineal research, 2021, Volume: 70, Issue:1

    Topics: Animals; Axons; Cells, Cultured; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases;

2021
Melatonin promotes Schwann cell proliferation and migration via the shh signalling pathway after peripheral nerve injury.
    The European journal of neuroscience, 2021, Volume: 53, Issue:3

    Topics: Animals; Cell Movement; Cell Proliferation; Melatonin; Mice; Nerve Regeneration; Peripheral Nerve In

2021
Possible effects of some agents on the injured nerve in obese rats: A stereological and electron microscopic study.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2017, Volume: 45, Issue:8

    Topics: Acetylcarnitine; Animals; Female; Leptin; Melatonin; Microscopy, Electron; Nerve Regeneration; Obesi

2017
Proliferative effects of melatonin on Schwann cells: implication for nerve regeneration following peripheral nerve injury.
    Journal of pineal research, 2014, Volume: 56, Issue:3

    Topics: Animals; Cell Line; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Male; Melatonin;

2014
Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
    Psychopharmacology, 2014, Volume: 231, Issue:20

    Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Hypnotics and Sedatives; Indoles; Male; M

2014
Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study.
    Central European neurosurgery, 2009, Volume: 70, Issue:3

    Topics: Animals; Axons; Injections, Intraperitoneal; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; M

2009
Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury.
    Journal of neuroscience methods, 2010, Aug-30, Volume: 191, Issue:2

    Topics: Animals; Disease Models, Animal; Male; Melatonin; Nerve Regeneration; Neuroprotective Agents; Periph

2010
Exacerbated mechanical allodynia in rats with depression-like behavior.
    Brain research, 2008, Mar-20, Volume: 1200

    Topics: Animals; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Gyrus Cingu

2008
Melatonin attenuates neuronal NADPH-d/NOS expression in the hypoglossal nucleus of adult rats following peripheral nerve injury.
    Brain research, 2000, Aug-11, Volume: 873, Issue:2

    Topics: Animals; Axotomy; Cell Count; Cell Death; Hypoglossal Nerve; Male; Melatonin; Motor Neurons; NADPH D

2000