melatonin has been researched along with Peptic Ulcer in 11 studies
Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin and L-tryptophan (Trp) are highly gastroprotective in humans, but no study has assessed their impact on healing of chronic gastroduodenal ulcers in humans." | 9.15 | Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole. ( Bielanski, W; Brzozowski, T; Celinski, K; Cichoz-Lach, H; Konturek, PC; Konturek, SJ; Malgorzata, P; Reiter, RJ; Slomka, M, 2011) |
| "Melatonin is a potent reactive oxygen metabolite scavenger and antioxidant that has been shown to influence many physiological functions of the gastrointestinal (GI) tract including secretion, motility, digestion and absorption of nutrients." | 6.50 | Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. ( Brzozowska, I; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Strzalka, M, 2014) |
| "Melatonin and L-tryptophan (Trp) are highly gastroprotective in humans, but no study has assessed their impact on healing of chronic gastroduodenal ulcers in humans." | 5.15 | Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole. ( Bielanski, W; Brzozowski, T; Celinski, K; Cichoz-Lach, H; Konturek, PC; Konturek, SJ; Malgorzata, P; Reiter, RJ; Slomka, M, 2011) |
| "Depression, peptic ulcers, and sexual dysfunction may be exacerbated by a deficiency of melatonin." | 4.76 | Disorder of the pineal gland associated with depression, peptic ulcers, and sexual dysfunction. ( Maurizi, CP, 1984) |
| "Melatonin is a potent reactive oxygen metabolite scavenger and antioxidant that has been shown to influence many physiological functions of the gastrointestinal (GI) tract including secretion, motility, digestion and absorption of nutrients." | 2.50 | Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. ( Brzozowska, I; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Strzalka, M, 2014) |
| "Melatonin was administered in three different doses of 5, 10 and 20 mg/kg, 30 minutes prior to the administration of indomethacin." | 1.31 | Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury. ( Bhargava, VK; Garg, SK; Singh, P, 2002) |
| "Melatonin was also highly effective in scavenging *OH generated in vitro by a Cu2+-ascorbate system." | 1.31 | Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical. ( Bandyopadhyay, D; Bandyopadhyay, U; Banerjee, RK; Biswas, K; Reiter, RJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brzozowska, I | 1 |
| Strzalka, M | 1 |
| Drozdowicz, D | 1 |
| Konturek, SJ | 2 |
| Brzozowski, T | 2 |
| Zhu, A | 1 |
| Kaunitz, J | 1 |
| Celinski, K | 1 |
| Konturek, PC | 1 |
| Cichoz-Lach, H | 1 |
| Slomka, M | 1 |
| Malgorzata, P | 1 |
| Bielanski, W | 1 |
| Reiter, RJ | 3 |
| Tsimmerman, IaS | 1 |
| Bandyopadhyay, D | 2 |
| Bandyopadhyay, A | 1 |
| Das, PK | 1 |
| Singh, P | 1 |
| Bhargava, VK | 1 |
| Garg, SK | 1 |
| Maurizi, CP | 1 |
| Kato, K | 2 |
| Murai, I | 2 |
| Asai, S | 2 |
| Komuro, S | 2 |
| Matsuno, Y | 1 |
| Matsukawa, Y | 1 |
| Kurosaka, H | 1 |
| Iwasaki, A | 2 |
| Ishikawa, K | 2 |
| Arakawa, Y | 2 |
| Biswas, K | 1 |
| Bandyopadhyay, U | 1 |
| Banerjee, RK | 1 |
| Nagata, T | 1 |
| Takahashi, Y | 1 |
| Khan, R | 1 |
| Daya, S | 1 |
| Potgieter, B | 1 |
4 reviews available for melatonin and Peptic Ulcer
| Article | Year |
|---|---|
Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease.
Topics: Esophagus; Gastroesophageal Reflux; Humans; Melatonin; Peptic Ulcer | 2014 |
Gastroduodenal mucosal defense.
Topics: Age Factors; Animals; Annexins; Calcitonin Gene-Related Peptide; Circadian Rhythm; Gastric Mucosa; H | 2008 |
[Ulcer disease: challenging problems of etiology, pathogenesis, differential treatment].
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; Disease Management; Drug Resistance, Multipl | 2012 |
Disorder of the pineal gland associated with depression, peptic ulcers, and sexual dysfunction.
Topics: Biological Clocks; Brain Diseases; Depressive Disorder; Female; Humans; Male; Melatonin; Peptic Ulce | 1984 |
1 trial available for melatonin and Peptic Ulcer
| Article | Year |
|---|---|
Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole.
Topics: Adult; Drug Therapy, Combination; Female; Humans; Male; Melatonin; Middle Aged; Omeprazole; Peptic U | 2011 |
6 other studies available for melatonin and Peptic Ulcer
| Article | Year |
|---|---|
Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Free Radical Scavengers; Gastric Mucos | 2002 |
Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury.
Topics: Animals; Antioxidants; beta Carotene; Gastric Mucosa; Indomethacin; Male; Melatonin; Peptic Ulcer; R | 2002 |
Central effect of melatonin against stress-induced gastric ulcers in rats.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Melatonin; | 1997 |
Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cold Temperature; Dose-Response Relationship, Drug; Free R | 2000 |
Melatonin's gastroprotective and antistress roles involve both central and peripheral effects.
Topics: Animals; Cisterna Magna; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Injections; | 2001 |
Evidence for a modulation of the stress response by the pineal gland.
Topics: Animals; Circadian Rhythm; Cold Temperature; Female; Melatonin; Peptic Ulcer; Pineal Gland; Rats; Ra | 1990 |