melatonin has been researched along with Pancreatitis in 44 studies
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite melatonin treatment diminishes inflammatory mediator production and improves organ injury after acute pancreatitis (AP), the mechanisms remain unknown." | 7.91 | Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway. ( Chen, TH; Cheng, HT; Chiang, KC; Hsu, JT; Kuo, CJ; Le, PH; Lin, CJ; Wu, RC, 2019) |
| "The aim of the present study was to investigate the protective mechanism underlying of melatonin in severe acute pancreatitis (SAP)." | 7.88 | Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Shao, B; Wu, J; Zhang, Y; Zhao, Q, 2018) |
| "The objective of this study is to explore the effect of melatonin on endoplasmic reticulum stress in acute pancreatitis (AP) and the molecular mechanism." | 7.88 | Melatonin Attenuates Endoplasmic Reticulum Stress in Acute Pancreatitis. ( Chen, Q; Huang, J; Li, J; Sun, Y; Tang, X; Wu, J; Zhao, Q, 2018) |
| "Melatonin protects the pancreas from inflammation and free radical damage but the effect of the melatonin metabolite: N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) on acute pancreatitis is unknown." | 7.83 | Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies. ( Bonior, J; Czech, U; Goralska, M; Jaworek, J; Kot, M; Pierzchalski, P; Reiter, RJ; Szklarczyk, J; Tomaszewska, R, 2016) |
| "Melatonin, which is mainly secreted by the pineal gland and released into blood, has anti-inflammatory properties in acute pancreatitis." | 7.83 | Melatonin Induces Anti-Inflammatory Effects to Play a Protective Role via Endoplasmic Reticulum Stress in Acute Pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Sun, Y; Wu, J; Zhang, J; Zhao, Q, 2016) |
| "Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress and increase of the activities of antioxidant enzymes in cerulein-induced acute pancreatitis." | 7.80 | Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. ( Carrasco, C; Pariente, JA; Rodriguez, AB, 2014) |
| "The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers." | 7.80 | [Results of dynamic assessment of melatonin receptor expression in lymphocytes in patients with acute mild and severe pancreatitis]. ( Gorchakova, MV; Osmanov, ZKh; Semenov, DIu; Shapkina, LG; Sokolov, AV; Tonoian, AG, 2014) |
| "To assess the value of plasma melatonin in predicting acute pancreatitis when combined with the acute physiology and chronic health evaluation II (APACHEII) and bedside index for severity in acute pancreatitis (BISAP) scoring systems." | 7.79 | Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. ( Chen, MJ; Dong, LM; Jin, Y; Lin, CJ; Wu, JS; Zhou, Q, 2013) |
| "The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis." | 7.79 | Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis. ( Carrasco, C; Holguín-Arévalo, MS; Marchena, AM; Martín-Partido, G; Paredes, SD; Pariente, JA; Rodríguez, AB, 2013) |
| "Seventy-two male Sprague-Dawley rats were randomly divided into three groups: the sham operation (SO), severe acute pancreatitis (SAP), and melatonin treatment (MT) groups." | 7.78 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22. ( Chen, MJ; Huai, JP; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Ye, XH, 2012) |
| "Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects." | 7.77 | Protective role of endogenous melatonin in the early course of human acute pancreatitis. ( Belyaev, O; Bolik, B; Herzog, T; Müller, CA; Munding, J; Uhl, W; Vosschulte, A, 2011) |
| "Injection of exogenous melatonin in rats with obstructive acute pancreatitis for seven days prevents acinar cell degeneration, apoptosis and polymorphonuclear leukocyte infiltration." | 7.76 | Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation. ( Büyükaşik, O; Çöl, C; Dınler, K; Firat, T; Hasdemır, O; Kükner, A, 2010) |
| "Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis." | 7.76 | Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. ( Bugdayci, G; Buyukasik, O; Col, C; Dinler, K; Hasdemir, O, 2010) |
| "To investigate the role of oxidative injury in pancreatitis-induced hepatic damage and the effect of antioxidant agents such as melatonin, ascorbic acid and N-acetyl cysteine on caerulein-induced pancreatitis and associated liver injury in rats." | 7.73 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats. ( Ates, B; Batçioğlu, K; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis." | 7.73 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats. ( Hegyi, P; Jarmay, K; Kaszaki, J; Letoha, T; Lonovics, J; Papai, G; Rakonczay, Z; Reiter, RJ; Sari, R; Szabolcs, A; Takacs, T; Varga, I, 2006) |
| "This study evaluated the expression of neutrophil apoptosis and the effects of melatonin at different concentrations on delayed neutrophil apoptosis in different severities of acute pancreatitis in patients." | 7.73 | Delayed neutrophil apoptosis attenuated by melatonin in human acute pancreatitis. ( Chen, HM; Chen, JC; Chen, MF; Chiu, DF; Hsu, JT; Ng, CJ, 2005) |
| "Melatonin has been used to treat experimental pancreatitis, although not all the drug's therapeutic mechanisms of melatonin have been defined." | 7.73 | Melatonin reduces pancreatic prostaglandins production and protects against caerulein-induced pancreatitis in rats. ( Chen, HM; Chen, JC; Chen, MF; Chiu, DF; Ng, CJ, 2006) |
| " We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury." | 7.72 | Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004) |
| "Melatonin, an antioxidant, protects the pancreas against acute inflammation but, although this indole is released mainly at night, no study has been undertaken to determine circadian changes of plasma melatonin levels and the severity of acute pancreatitis." | 7.72 | The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat. ( Bonior, J; Jaworek, J; Konturek, SJ; Leja-Szpak, A; Nawrot, K; Palonek, M; Pawlik, WW; Stachura, J; Tomaszewska, R, 2004) |
| "The present study investigated the involvement of endogenous melatonin in the prevention of pancreatic damage provoked by caerulein-induced pancreatitis (CIP) by using the luzindole, the antagonist of melatonin MT2 receptors." | 7.71 | Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat. ( Bonior, J; Jaworek, J; Konturek, SJ; Leja-Szpak, A; Nawrot, K; Pawlik, WW; Stachura, J; Tomaszewska, R, 2002) |
| "Since oxygen free radicals and lipid peroxidation have been implicated in the pathogenesis of an early stage of acute pancreatitis, we examined whether melatonin, a recently discovered free-radical scavenger, could attenuate pancreatic injury in Sprague-Dawley rats with cerulein-induced pancreatitis." | 7.70 | Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. ( Cabrera, J; Kim, SJ; Manchester, LC; Mayo, JC; Qi, W; Reiter, RJ; Sainz, RM; Tan, DX, 1999) |
| "Melatonin is an indoleamine which is produced from L-tryptophan in the pineal gland and in the other tissue including gastrointestinal tract." | 6.50 | The role of melatonin in pancreatic protection: could melatonin be used in the treatment of acute pancreatitis? ( Bonior, J; Jaworek, A; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porbka, K; Szklarczyk, J, 2014) |
| "Whether acute pancreatitis develops as the severe type or resolves depends on the intensity of the inflammatory process which is counteracted by the recruitment of innate defense mechanisms." | 6.50 | Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin. ( Jaworek, J; Konturek, SJ, 2014) |
| "Melatonin has been mentioned as a protective factor against acute pancreatitis." | 5.51 | Does melatonin addition to indomethacin decrease post endoscopic retrograde cholangiopancreatography pancreatitis? A randomized double-blind controlled trial. ( Abbasinazari, M; Abdi, S; Asadzadeh Aghdaei, H; Hatami, B; Jamshidzadeh, S; Rasoolinezhad, M; Saadati, S; Sadeghi, A, 2019) |
| "Severe acute pancreatitis is associated with high morbidity and mortality." | 5.51 | Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research. ( Bachmann, K; Erbes, J; Gocht, A; Grupp, K; Havel, J; Izbicki, JR; Mann, O; Poppe, A; Trepte, C; Wodack, K, 2019) |
| "Pre‑treatment with melatonin was further used to identify the potential anti‑inflammatory mechanisms in AP." | 5.48 | Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis. ( Che, Q; Huang, J; Jin, Y; Li, J; Sun, Y; Wu, J; Yu, H; Zhang, H; Zhao, Q, 2018) |
| "Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects." | 5.40 | Pulmonary function changes in rats with taurocholate-induced pancreatitis are attenuated by pretreatment with melatonin. ( Chen, KH; Chou, TY; Leu, FJ; Reiter, RJ; Wang, D; Yeh, DY, 2014) |
| "Melatonin treatment was found to be beneficial in acute pancreatitis." | 5.36 | Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis. ( Khanduja, KL; Malhotra, S; Pandhi, P; Sidhu, S; Vaiphei, K, 2010) |
| "Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats." | 5.35 | The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. ( Bugdayci, G; Cöl, C; Dinler, K; Hasdemir, AO, 2009) |
| "Acute pancreatitis was induced by two i." | 5.33 | Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. ( Ateş, B; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "Melatonin was intraperitoneally administered before or/and after IR injury." | 5.33 | Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. ( Briceño, J; Collado, JA; Cruz, A; Montilla, P; Muñoz-Casares, FC; Muñoz-Castañeda, JR; Muntané, J; Ortega, R; Padillo, FJ; Pera, C; Túnez, I, 2006) |
| "Acute pancreatitis was induced by subcutaneous infusion of caerulein (5 microg/kg-h x 5 h)." | 5.32 | Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action. ( Bonior, J; Czupryna, A; Jaworek, J; Konturek, SJ; Kot, M; Leja-Szpak, A; Nawrot, K; Palonek, M; Pawlik, WW; Stachura, J; Tomaszewska, R, 2004) |
| "We carried out a literature search of random controlled trials (RCTs) on preventing post-operative pancreatitis by administration of the anti-inflammatory drugs, indomethacin and diclofenac, following endoscopic retrograde cholangiopancreatography (ERCP)." | 5.22 | Efficacy of Combined Management with Nonsteroidal Anti-inflammatory Drugs for Prevention of Pancreatitis After Endoscopic Retrograde Cholangiography: a Bayesian Network Meta-analysis. ( Du, F; Fan, H; Ren, L; Yang, X; Yuan, W; Zhang, L; Zhang, Y, 2022) |
| "Despite melatonin treatment diminishes inflammatory mediator production and improves organ injury after acute pancreatitis (AP), the mechanisms remain unknown." | 3.91 | Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway. ( Chen, TH; Cheng, HT; Chiang, KC; Hsu, JT; Kuo, CJ; Le, PH; Lin, CJ; Wu, RC, 2019) |
| "The aim of the present study was to investigate the protective mechanism underlying of melatonin in severe acute pancreatitis (SAP)." | 3.88 | Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Shao, B; Wu, J; Zhang, Y; Zhao, Q, 2018) |
| "The objective of this study is to explore the effect of melatonin on endoplasmic reticulum stress in acute pancreatitis (AP) and the molecular mechanism." | 3.88 | Melatonin Attenuates Endoplasmic Reticulum Stress in Acute Pancreatitis. ( Chen, Q; Huang, J; Li, J; Sun, Y; Tang, X; Wu, J; Zhao, Q, 2018) |
| "To evaluate m-RNA expressions of SERCA2 and NCX1 in acute pancreatitis induced by sodium taurocholate in Wistar rats pre-treated with melatonin and/or TD." | 3.88 | THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE. ( Chaib, E; Coelho, AM; Cunha, JEM; D'Albuquerque, LAC; Kubrusly, MS; Lima, MA; Nader, HB; Sanpietri, SN; Tersariol, ILS; Vasques, ER, 2018) |
| "Melatonin protects the pancreas from inflammation and free radical damage but the effect of the melatonin metabolite: N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) on acute pancreatitis is unknown." | 3.83 | Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies. ( Bonior, J; Czech, U; Goralska, M; Jaworek, J; Kot, M; Pierzchalski, P; Reiter, RJ; Szklarczyk, J; Tomaszewska, R, 2016) |
| "Melatonin, which is mainly secreted by the pineal gland and released into blood, has anti-inflammatory properties in acute pancreatitis." | 3.83 | Melatonin Induces Anti-Inflammatory Effects to Play a Protective Role via Endoplasmic Reticulum Stress in Acute Pancreatitis. ( Chen, Q; Chen, Y; Jin, Y; Sun, Y; Wu, J; Zhang, J; Zhao, Q, 2016) |
| "Melatonin, a polyvalent antioxidant, protected the pancreatic damage via the decrease of oxidative stress and increase of the activities of antioxidant enzymes in cerulein-induced acute pancreatitis." | 3.80 | Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. ( Carrasco, C; Pariente, JA; Rodriguez, AB, 2014) |
| "The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers." | 3.80 | [Results of dynamic assessment of melatonin receptor expression in lymphocytes in patients with acute mild and severe pancreatitis]. ( Gorchakova, MV; Osmanov, ZKh; Semenov, DIu; Shapkina, LG; Sokolov, AV; Tonoian, AG, 2014) |
| "The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis." | 3.79 | Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis. ( Carrasco, C; Holguín-Arévalo, MS; Marchena, AM; Martín-Partido, G; Paredes, SD; Pariente, JA; Rodríguez, AB, 2013) |
| "To assess the value of plasma melatonin in predicting acute pancreatitis when combined with the acute physiology and chronic health evaluation II (APACHEII) and bedside index for severity in acute pancreatitis (BISAP) scoring systems." | 3.79 | Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. ( Chen, MJ; Dong, LM; Jin, Y; Lin, CJ; Wu, JS; Zhou, Q, 2013) |
| "Seventy-two male Sprague-Dawley rats were randomly divided into three groups: the sham operation (SO), severe acute pancreatitis (SAP), and melatonin treatment (MT) groups." | 3.78 | Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22. ( Chen, MJ; Huai, JP; Huang, ZM; Jin, Y; Sun, XC; Wu, JS; Ye, XH, 2012) |
| "Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects." | 3.77 | Protective role of endogenous melatonin in the early course of human acute pancreatitis. ( Belyaev, O; Bolik, B; Herzog, T; Müller, CA; Munding, J; Uhl, W; Vosschulte, A, 2011) |
| "Injection of exogenous melatonin in rats with obstructive acute pancreatitis for seven days prevents acinar cell degeneration, apoptosis and polymorphonuclear leukocyte infiltration." | 3.76 | Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation. ( Büyükaşik, O; Çöl, C; Dınler, K; Firat, T; Hasdemır, O; Kükner, A, 2010) |
| "Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis." | 3.76 | Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. ( Bugdayci, G; Buyukasik, O; Col, C; Dinler, K; Hasdemir, O, 2010) |
| "Melatonin has been used to treat experimental pancreatitis, although not all the drug's therapeutic mechanisms of melatonin have been defined." | 3.73 | Melatonin reduces pancreatic prostaglandins production and protects against caerulein-induced pancreatitis in rats. ( Chen, HM; Chen, JC; Chen, MF; Chiu, DF; Ng, CJ, 2006) |
| "This study evaluated the expression of neutrophil apoptosis and the effects of melatonin at different concentrations on delayed neutrophil apoptosis in different severities of acute pancreatitis in patients." | 3.73 | Delayed neutrophil apoptosis attenuated by melatonin in human acute pancreatitis. ( Chen, HM; Chen, JC; Chen, MF; Chiu, DF; Hsu, JT; Ng, CJ, 2005) |
| "To investigate the role of oxidative injury in pancreatitis-induced hepatic damage and the effect of antioxidant agents such as melatonin, ascorbic acid and N-acetyl cysteine on caerulein-induced pancreatitis and associated liver injury in rats." | 3.73 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats. ( Ates, B; Batçioğlu, K; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis." | 3.73 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats. ( Hegyi, P; Jarmay, K; Kaszaki, J; Letoha, T; Lonovics, J; Papai, G; Rakonczay, Z; Reiter, RJ; Sari, R; Szabolcs, A; Takacs, T; Varga, I, 2006) |
| " We characterized the protective effects of melatonin on pancreaticobiliary inflammation and associated remote organ injury." | 3.72 | Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils. ( Arbak, S; Bangir, D; Barlas, A; Cevik, H; Sener, G; Yeğen, BC; Yeğen, C, 2004) |
| "Melatonin, an antioxidant, protects the pancreas against acute inflammation but, although this indole is released mainly at night, no study has been undertaken to determine circadian changes of plasma melatonin levels and the severity of acute pancreatitis." | 3.72 | The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat. ( Bonior, J; Jaworek, J; Konturek, SJ; Leja-Szpak, A; Nawrot, K; Palonek, M; Pawlik, WW; Stachura, J; Tomaszewska, R, 2004) |
| "The present study investigated the involvement of endogenous melatonin in the prevention of pancreatic damage provoked by caerulein-induced pancreatitis (CIP) by using the luzindole, the antagonist of melatonin MT2 receptors." | 3.71 | Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat. ( Bonior, J; Jaworek, J; Konturek, SJ; Leja-Szpak, A; Nawrot, K; Pawlik, WW; Stachura, J; Tomaszewska, R, 2002) |
| "Clinicoendoscopic morphological and morphofunctional studies in 50 patients with chronic cholecystitis and 50 patients with chronic biliary pancreatitis have demonstrated that morphometric analysis of the antral stomach endocrine cells secreting melatonin, neurotensin and somatostatin can be used in addition to standard laboratory and device methods for differentiation chronic biliary pancreatitis with biliary pathology." | 3.71 | [Morphofunctional characteristics of endocrine gastric cells in chronic biliary pancreatitis]. ( Balashov, VI; Kvetnoĭ, IM; Lipatova, TE; Osadchuk, MA, 2001) |
| "Since oxygen free radicals and lipid peroxidation have been implicated in the pathogenesis of an early stage of acute pancreatitis, we examined whether melatonin, a recently discovered free-radical scavenger, could attenuate pancreatic injury in Sprague-Dawley rats with cerulein-induced pancreatitis." | 3.70 | Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. ( Cabrera, J; Kim, SJ; Manchester, LC; Mayo, JC; Qi, W; Reiter, RJ; Sainz, RM; Tan, DX, 1999) |
| "Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melatonin are known as kynuramines." | 2.55 | Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis. ( Bonior, J; Ceranowicz, P; Dembinski, A; Góralska, M; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porąbka, K; Pierzchalski, P; Szklarczyk, J; Warzecha, Z, 2017) |
| "Whether acute pancreatitis develops as the severe type or resolves depends on the intensity of the inflammatory process which is counteracted by the recruitment of innate defense mechanisms." | 2.50 | Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin. ( Jaworek, J; Konturek, SJ, 2014) |
| "Melatonin is an indoleamine which is produced from L-tryptophan in the pineal gland and in the other tissue including gastrointestinal tract." | 2.50 | The role of melatonin in pancreatic protection: could melatonin be used in the treatment of acute pancreatitis? ( Bonior, J; Jaworek, A; Jaworek, J; Kot, M; Leja-Szpak, A; Nawrot-Porbka, K; Szklarczyk, J, 2014) |
| "Melatonin was thought to originate primarily from the pineal gland and to be secreted during the night, but recent studies revealed that gastrointestinal (GI) tract presents another, many times larger, source of melatonin that contributes significantly to the circulating concentration of this indole." | 2.43 | Melatonin as an organoprotector in the stomach and the pancreas. ( Brzozowski, T; Jaworek, J; Konturek, SJ, 2005) |
| "Melatonin has been mentioned as a protective factor against acute pancreatitis." | 1.51 | Does melatonin addition to indomethacin decrease post endoscopic retrograde cholangiopancreatography pancreatitis? A randomized double-blind controlled trial. ( Abbasinazari, M; Abdi, S; Asadzadeh Aghdaei, H; Hatami, B; Jamshidzadeh, S; Rasoolinezhad, M; Saadati, S; Sadeghi, A, 2019) |
| "Severe acute pancreatitis is associated with high morbidity and mortality." | 1.51 | Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research. ( Bachmann, K; Erbes, J; Gocht, A; Grupp, K; Havel, J; Izbicki, JR; Mann, O; Poppe, A; Trepte, C; Wodack, K, 2019) |
| "Pre‑treatment with melatonin was further used to identify the potential anti‑inflammatory mechanisms in AP." | 1.48 | Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis. ( Che, Q; Huang, J; Jin, Y; Li, J; Sun, Y; Wu, J; Yu, H; Zhang, H; Zhao, Q, 2018) |
| "Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects." | 1.40 | Pulmonary function changes in rats with taurocholate-induced pancreatitis are attenuated by pretreatment with melatonin. ( Chen, KH; Chou, TY; Leu, FJ; Reiter, RJ; Wang, D; Yeh, DY, 2014) |
| "Melatonin treatment was found to be beneficial in acute pancreatitis." | 1.36 | Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis. ( Khanduja, KL; Malhotra, S; Pandhi, P; Sidhu, S; Vaiphei, K, 2010) |
| "Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats." | 1.35 | The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. ( Bugdayci, G; Cöl, C; Dinler, K; Hasdemir, AO, 2009) |
| "The prognosis of acute pancreatitis (AP) depends upon the degree of pancreatic necrosis and the intensity of multisystem organ failure." | 1.35 | Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis. ( Eşrefoğlu, M; Gül, M; Turan, F, 2008) |
| "Acute pancreatitis was induced by two i." | 1.33 | Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. ( Ateş, B; Eşrefoğlu, M; Gül, M; Selimoğlu, MA, 2006) |
| "Melatonin was intraperitoneally administered before or/and after IR injury." | 1.33 | Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. ( Briceño, J; Collado, JA; Cruz, A; Montilla, P; Muñoz-Casares, FC; Muñoz-Castañeda, JR; Muntané, J; Ortega, R; Padillo, FJ; Pera, C; Túnez, I, 2006) |
| "Acute pancreatitis was induced by subcutaneous infusion of caerulein (5 microg/kg-h x 5 h)." | 1.32 | Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action. ( Bonior, J; Czupryna, A; Jaworek, J; Konturek, SJ; Kot, M; Leja-Szpak, A; Nawrot, K; Palonek, M; Pawlik, WW; Stachura, J; Tomaszewska, R, 2004) |
| "Leptin and melatonin have been recently reported to affect the inflammatory response of various tissues." | 1.31 | Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin. ( Bonio, J; Jaworek, J; Konturek, SJ; Leja-Szpa, A; Nawrot, K; Pawlik, WW; Stachura, J; Tomaszewska, MR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.27) | 18.2507 |
| 2000's | 17 (38.64) | 29.6817 |
| 2010's | 24 (54.55) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Du, F | 1 |
| Zhang, Y | 2 |
| Yang, X | 1 |
| Zhang, L | 1 |
| Yuan, W | 1 |
| Fan, H | 1 |
| Ren, L | 1 |
| Sadeghi, A | 1 |
| Abbasinazari, M | 1 |
| Asadzadeh Aghdaei, H | 1 |
| Abdi, S | 1 |
| Hatami, B | 1 |
| Rasoolinezhad, M | 1 |
| Jamshidzadeh, S | 1 |
| Saadati, S | 1 |
| Zhao, Q | 5 |
| Zhang, H | 2 |
| Wu, J | 5 |
| Lv, X | 1 |
| Jin, X | 1 |
| Hu, J | 1 |
| Jaworek, J | 11 |
| Leja-Szpak, A | 7 |
| Nawrot-Porąbka, K | 2 |
| Szklarczyk, J | 4 |
| Kot, M | 5 |
| Pierzchalski, P | 2 |
| Góralska, M | 2 |
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7 reviews available for melatonin and Pancreatitis
| Article | Year |
|---|---|
Efficacy of Combined Management with Nonsteroidal Anti-inflammatory Drugs for Prevention of Pancreatitis After Endoscopic Retrograde Cholangiography: a Bayesian Network Meta-analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopi | 2022 |
Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis.
Topics: Animals; Carcinogenesis; Humans; Melatonin; Pancreas; Pancreatic Neoplasms; Pancreatitis; Receptors, | 2017 |
The role of melatonin in pancreatic protection: could melatonin be used in the treatment of acute pancreatitis?
Topics: Acute Disease; Humans; Melatonin; Pancreas; Pancreatitis; Receptors, Melatonin | 2014 |
Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Ghrelin; Humans; Inflammation Mediators; Leptin; M | 2014 |
[Protective role of melatonin in pancreatic gland disorders].
Topics: Acute Disease; Animals; Central Nervous System Depressants; Diabetes Mellitus; Humans; Melatonin; Pa | 2012 |
Melatonin as an organoprotector in the stomach and the pancreas.
Topics: Animals; Humans; Melatonin; Pancreas; Pancreatitis; Stomach; Stomach Ulcer | 2005 |
Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Cholecystokinin; Free Radical Scavengers; Gastrointest | 2007 |
37 other studies available for melatonin and Pancreatitis
| Article | Year |
|---|---|
Does melatonin addition to indomethacin decrease post endoscopic retrograde cholangiopancreatography pancreatitis? A randomized double-blind controlled trial.
Topics: Adult; Aged; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholangiopancreatograp | 2019 |
Melatonin inhibits the endoplasmic reticulum stress‑induced, C/EBP homologous protein‑mediated pathway in acute pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Inflam | 2020 |
Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, A | 2018 |
Melatonin Attenuates Endoplasmic Reticulum Stress in Acute Pancreatitis.
Topics: Acute Disease; Animals; Antioxidants; Apoptosis; Cell Line; Ceruletide; Cytokines; Endoplasmic Retic | 2018 |
THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.
Topics: Acute Disease; Animals; Cytoprotection; Disaccharides; Disease Models, Animal; Male; Melatonin; Panc | 2018 |
Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Biomarkers; Endoplasmic Reticulum Stress; Inflammation; Male; Mel | 2018 |
Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway.
Topics: Administration, Intravenous; Animals; Ceruletide; Disease Models, Animal; Humans; Inflammation Media | 2019 |
Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research.
Topics: Animals; Disease Models, Animal; Germany; Melatonin; Pancreas; Pancreatitis; Physical Fitness; Survi | 2019 |
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; APACHE; Biomarkers; Case-Control Studies; | 2013 |
Pulmonary function changes in rats with taurocholate-induced pancreatitis are attenuated by pretreatment with melatonin.
Topics: Animals; Antioxidants; Hydrogen Peroxide; Leukocytes; Lung; Melatonin; Organ Size; Oxidative Stress; | 2014 |
Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Antioxidants; Ceruletide; Cytokines; Fem | 2013 |
[Results of dynamic assessment of melatonin receptor expression in lymphocytes in patients with acute mild and severe pancreatitis].
Topics: Acute Disease; Adult; Female; Fluorescent Antibody Technique, Indirect; Humans; Lymphocytes; Male; M | 2014 |
Therapeutic implications of antioxidant defense in acute pancreatitis.
Topics: Animals; Antioxidants; Ceruletide; Female; Male; Melatonin; Oxidative Stress; Pancreas; Pancreatitis | 2014 |
Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Animals; Antioxidants; Ceruletide; Cytoprotection; Disease Models, Animal; Female; Gl | 2014 |
Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies.
Topics: Acute Disease; Aldehydes; Amylases; Animals; Anti-Inflammatory Agents; Antioxidants; bcl-2-Associate | 2016 |
Melatonin Induces Anti-Inflammatory Effects to Play a Protective Role via Endoplasmic Reticulum Stress in Acute Pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Autophagy; Cell Line; Cell Shape; Cell Survival; Endop | 2016 |
The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Injections, Intraperitoneal; | 2009 |
Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis.
Topics: Amylases; Animals; Disease Models, Animal; DNA; Female; Gene Expression Regulation; Immunohistochemi | 2010 |
Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Glutathione; Injections, I | 2010 |
Protective role of endogenous melatonin in the early course of human acute pancreatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antioxidants; E | 2011 |
Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation.
Topics: Acute Disease; Animals; Apoptosis; Atrophy; Disease Models, Animal; Injections, Intraperitoneal; Lig | 2010 |
Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22.
Topics: Acute Disease; Acute Lung Injury; Amylases; Animals; Immunity, Innate; Interleukin-22; Interleukins; | 2012 |
Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion.
Topics: Adjuvants, Immunologic; Animals; Ceruletide; Interleukin-10; Ischemia; Male; Melatonin; Pancreas; Pa | 2003 |
Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat.
Topics: Amylases; Animals; Ceruletide; Dose-Response Relationship, Drug; Lipase; Lipid Peroxidation; Male; M | 2002 |
Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action.
Topics: Acute Disease; Aldehydes; Amylases; Animals; Ceruletide; Dose-Response Relationship, Drug; Drug Admi | 2004 |
The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat.
Topics: Amylases; Animals; Ceruletide; Circadian Rhythm; Darkness; Dose-Response Relationship, Drug; Lipase; | 2004 |
Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils.
Topics: Animals; Antioxidants; Bile Ducts; Cholestasis; Female; Glutathione; Inflammation; Kidney; Liver; Lu | 2004 |
Delayed neutrophil apoptosis attenuated by melatonin in human acute pancreatitis.
Topics: Acute Disease; Adult; Apoptosis; CD18 Antigens; DNA Damage; Dose-Response Relationship, Drug; Female | 2005 |
Melatonin reduces pancreatic prostaglandins production and protects against caerulein-induced pancreatitis in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Ceruletide; Dinoprostone; Glutathione; Leukot | 2006 |
Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Autophagy; Catalase; Ceruletide; Female; Glutathione; Glutathione | 2006 |
Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Arginine; Catalase; Lipid Peroxidation; Male; Malondialdehyde; Mel | 2006 |
Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats.
Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Ascorbic Acid; Ceruletide; Female; Lipid Perox | 2006 |
Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas.
Topics: Amylases; Animals; Apoptosis; Caspase 3; Caspases; Catalase; DNA Fragmentation; Glutathione; Glutath | 2006 |
Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis.
Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Arginine; Ascorbic Acid; Ceruletide; Female; L | 2008 |
Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Edema; Free Radical Scavengers; Lipid Peroxidation; Ma | 1999 |
[Morphofunctional characteristics of endocrine gastric cells in chronic biliary pancreatitis].
Topics: Chronic Disease; Common Bile Duct Diseases; Diagnosis, Differential; Gastric Mucosa; Humans; Melaton | 2001 |
Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin.
Topics: Amylases; Animals; Antioxidants; Calcitonin Gene-Related Peptide; Carrier Proteins; Central Nervous | 2002 |