melatonin has been researched along with Neurofibromatosis 1 in 6 studies
Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We might hypothesize that the high rate of pseudarthrosis after spinal fusion for neurofibromatous scoliosis is related to two factors: the absence of neurofibromin and melatonin deficiency." | 7.71 | The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis. ( Abdel-Wanis, ME; Kawahara, N, 2002) |
| "The postoperative kyphosis and scoliosis angles were 30 degrees and 12 degrees, respectively." | 5.31 | The association of neurofibromatosis 1 and spinal deformity with primary hyperparathyroidism and osteomalacia: might melatonin have a role? ( Abdel-Wanis, ME; Kawahara, N; Tomita, K, 2001) |
| "We might hypothesize that the high rate of pseudarthrosis after spinal fusion for neurofibromatous scoliosis is related to two factors: the absence of neurofibromin and melatonin deficiency." | 3.71 | The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis. ( Abdel-Wanis, ME; Kawahara, N, 2002) |
| "Melatonin deficiency was proposed to be present in cases of neurofibromatosis 1 and to be an operating factor in progression of spinal deformities." | 1.31 | Hypophosphatemic osteomalacia in neurofibromatosis 1: hypotheses for pathogenesis and higher incidence of spinal deformity. ( Abdel-Wanis, M; Kawahara, N, 2002) |
| "Neurofibromatosis 1 is a common heritable disorder." | 1.31 | Aetiology of spinal deformities in neurofibromatosis 1: new hypotheses. ( Abdel-Wanis, ME; Kawahara, N, 2001) |
| "The postoperative kyphosis and scoliosis angles were 30 degrees and 12 degrees, respectively." | 1.31 | The association of neurofibromatosis 1 and spinal deformity with primary hyperparathyroidism and osteomalacia: might melatonin have a role? ( Abdel-Wanis, ME; Kawahara, N; Tomita, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Nasi, L | 1 |
| Alexopoulos, A | 1 |
| Kokkinou, E | 1 |
| Roka, K | 1 |
| Tzetis, M | 1 |
| Tsipi, M | 1 |
| Kakourou, T | 1 |
| Kanaka-Gantenbein, C | 1 |
| Chrousos, G | 1 |
| Kattamis, A | 1 |
| Pons, R | 1 |
| Abdel-Wanis, M | 1 |
| Kawahara, N | 4 |
| Namazi, H | 1 |
| Abdel-Wanis, ME | 3 |
| Tomita, K | 1 |
6 other studies available for melatonin and Neurofibromatosis 1
| Article | Year |
|---|---|
Characteristics of Café-au-lait Macules and their Association with the Neurofibromatosis type I Genotype in a Cohort of Greek Children.
Topics: Cafe-au-Lait Spots; Female; Genotype; Greece; Humans; Male; Melanins; Melatonin; Neurofibromatosis 1 | 2023 |
Hypophosphatemic osteomalacia in neurofibromatosis 1: hypotheses for pathogenesis and higher incidence of spinal deformity.
Topics: Hypophosphatemia, Familial; Incidence; Melatonin; Neurofibromatosis 1; Spine | 2002 |
Von Recklinghausen disease may be a pineal deficiency disease.
Topics: Humans; Melatonin; Neurofibromatosis 1; Pineal Gland | 2007 |
Aetiology of spinal deformities in neurofibromatosis 1: new hypotheses.
Topics: Calmodulin; Carrier Proteins; Humans; Melatonin; Models, Biological; Nerve Tissue Proteins; Neurofib | 2001 |
The association of neurofibromatosis 1 and spinal deformity with primary hyperparathyroidism and osteomalacia: might melatonin have a role?
Topics: Adenoma; Adult; Decompression, Surgical; Female; Humans; Hyperparathyroidism; Kyphosis; Melatonin; N | 2001 |
The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis.
Topics: Bone and Bones; Fibrosis; Humans; Melatonin; Models, Biological; Neurofibromatosis 1; Neurofibromin | 2002 |