melatonin has been researched along with Neuralgia in 30 studies
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a." | 7.67 | Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 5.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "Previous study has shown that administration of melatonin into the anterior cingulate cortex contralateral to peripheral nerve injury prevented exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats." | 3.75 | A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. ( Chou, CW; Hernstadt, H; Lim, G; Ma, Y; Mao, J; Rusanescu, G; Sung, B; Tian, Y; Wang, S; Zhang, L, 2009) |
| "In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a." | 3.67 | Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987) |
| "Melatonin (MLT) has been implicated in several pathophysiological states, including pain." | 2.58 | Targeting Melatonin MT2 Receptors: A Novel Pharmacological Avenue for Inflammatory and Neuropathic Pain. ( Comai, S; De Gregorio, D; Gobbi, G; Posa, L, 2018) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 1.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "Melatonin treatment increased the expression of neuronal sirtuin1 (SIRT1) in DRGs following nerve injury." | 1.91 | Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions. ( Chen, J; Fang, Q; Huang, H; Liu, X; Shi, Y; Wang, Y; Wu, W; Yao, M; Zeng, Y; Zhan, H; Zhang, X; Zhong, X, 2023) |
| "Melatonin (MLT) has been implicated in several pathophysiological states, including pain." | 1.72 | Acute and Chronic Pain Preclinical Models to Study the Analgesic Properties of Melatonergic Compounds. ( Comai, S; De Gregorio, D, 2022) |
| " However, it can also induce peripheral neuropathic pain and neurotoxicity as adverse effects." | 1.62 | Melatonin and Selenium Suppress Docetaxel-Induced TRPV1 Activation, Neuropathic Pain and Oxidative Neurotoxicity in Mice. ( Ataizi, ZS; Ertilav, K; Nazıroğlu, M; Yıldızhan, K, 2021) |
| "EA of ST36 and SP6 can alleviate neuropathic pain in CCI rats, which is closely related to its effect in inhibiting the release of IL-17 from astrocytes mediated by MT2." | 1.62 | [Melatonin receptor 2 mediated spinal dorsal horn astrocytes IL-17 inhibition contributes to electroacupuncture analgesia in neuropathic pain rats]. ( Chen, QH; Dai, QX; Deng, LY; Zhou, S, 2021) |
| "Melatonin (Mel) was administered to ameliorate the sleep-awake rhythm (CCI-free + Mel and CCI-misaligned + Mel)." | 1.48 | Misaligned Feeding May Aggravate Pain by Disruption of Sleep-Awake Rhythm. ( Chu, S; Gong, X; Gu, X; Liu, H; Ma, Z; Shao, X; Xu, F; Zhao, X, 2018) |
| "Neuropathic pain is a severe condition with unsatisfactory treatments." | 1.46 | Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats. ( Bonazza, V; Borsani, E; Buffoli, B; Reiter, RJ; Rezzani, R; Rodella, LF, 2017) |
| "A mouse model of chronic neuropathic pain induced by partial sciatic nerve ligation (PSL) was employed." | 1.40 | Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. ( Chen, CR; Chen, L; Cheng, NN; Huang, ZL; Laudon, M; Liu, YY; Qu, WM; Urade, Y; Yin, D, 2014) |
| "Melatonin was administered at 23:00 once a day." | 1.40 | Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion. ( Chen, CL; Chiang, RP; Huang, CT; Tsai, YJ, 2014) |
| "Oral melatonin treatment further potentiated RW activity-induced cell survival in both areas of the dentate gyrus [melatonin (n = 10) versus vehicle (n = 7): dorsal, 63 ± 5." | 1.39 | Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus. ( Dubocovich, ML; Hudson, RL; Liu, J; Somera-Molina, KC, 2013) |
| "Melatonin treatment dose-dependently attenuated p-p38 MAPK levels, release of pro-inflammatory cytokines, and behavioral hypersensitivity following CCI; conversely, pinealectomy that resulted in a reduction in endogenous melatonin levels exacerbated these effects." | 1.39 | Melatonin reduces median nerve injury-induced mechanical hypersensitivity via inhibition of microglial p38 mitogen-activated protein kinase activation in rat cuneate nucleus. ( Chiang, RP; Huang, CT; Tsai, YJ, 2013) |
| " Chronic administration of melatonin (2." | 1.37 | Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats. ( Gupta, A; Kalonia, H; Kumar, A; Kumar, P; Meena, S, 2011) |
| "Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior." | 1.35 | Exacerbated mechanical allodynia in rats with depression-like behavior. ( Chang, Y; Guo, G; Lim, G; Lim, JA; Mao, J; Sung, B; Wang, S; Yang, L; Zeng, Q, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 12 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Posa, L | 2 |
| De Gregorio, D | 3 |
| Lopez-Canul, M | 1 |
| He, Q | 1 |
| Darcq, E | 1 |
| Rullo, L | 1 |
| Pearl-Dowler, L | 1 |
| Luongo, L | 1 |
| Candeletti, S | 1 |
| Romualdi, P | 1 |
| Kieffer, BL | 1 |
| Gobbi, G | 2 |
| Comai, S | 2 |
| Mokhtari, T | 1 |
| Yue, LP | 1 |
| Hu, L | 1 |
| Kaur, T | 1 |
| Huang, AC | 1 |
| Shyu, BC | 1 |
| Zeng, Y | 1 |
| Fang, Q | 1 |
| Chen, J | 1 |
| Wang, Y | 1 |
| Liu, X | 1 |
| Zhang, X | 1 |
| Shi, Y | 1 |
| Zhan, H | 1 |
| Zhong, X | 1 |
| Yao, M | 1 |
| Huang, H | 1 |
| Wu, W | 1 |
| Hsieh, MC | 2 |
| Lai, CY | 2 |
| Lin, LT | 1 |
| Chou, D | 2 |
| Yeh, CM | 1 |
| Cheng, JK | 1 |
| Wang, HH | 2 |
| Lin, KH | 1 |
| Lin, TB | 2 |
| Peng, HY | 2 |
| Ertilav, K | 1 |
| Nazıroğlu, M | 1 |
| Ataizi, ZS | 1 |
| Yıldızhan, K | 1 |
| Huang, CT | 3 |
| Chen, SH | 1 |
| Chang, CF | 1 |
| Lin, SC | 1 |
| Lue, JH | 1 |
| Tsai, YJ | 3 |
| Fakhri, S | 1 |
| Kiani, A | 1 |
| Jalili, C | 1 |
| Abbaszadeh, F | 1 |
| Piri, S | 1 |
| Farzaei, MH | 1 |
| Rastegari-Pouyani, M | 1 |
| Mohammadi-Noori, E | 1 |
| Khan, H | 1 |
| Wang, YH | 1 |
| Tang, YR | 1 |
| Gao, X | 1 |
| Liu, J | 2 |
| Zhang, NN | 1 |
| Liang, ZJ | 1 |
| Li, Y | 1 |
| Pan, LX | 1 |
| Martínez, AL | 1 |
| Brea, J | 1 |
| Barro, M | 1 |
| Monroy, X | 1 |
| Merlos, M | 1 |
| Burgueño, J | 1 |
| Loza, MI | 1 |
| Deng, LY | 1 |
| Zhou, S | 1 |
| Chen, QH | 1 |
| Dai, QX | 1 |
| Lin, JJ | 1 |
| Lin, Y | 1 |
| Zhao, TZ | 1 |
| Zhang, CK | 1 |
| Zhang, T | 1 |
| Chen, XL | 1 |
| Ding, JQ | 1 |
| Chang, T | 1 |
| Zhang, Z | 1 |
| Sun, C | 1 |
| Zhao, DD | 1 |
| Zhu, JL | 1 |
| Li, ZY | 1 |
| Li, JL | 1 |
| Ho, YC | 1 |
| Chen, GD | 1 |
| Galley, HF | 1 |
| McCormick, B | 1 |
| Wilson, KL | 1 |
| Lowes, DA | 1 |
| Colvin, L | 1 |
| Torsney, C | 1 |
| Borsani, E | 1 |
| Buffoli, B | 1 |
| Bonazza, V | 1 |
| Reiter, RJ | 1 |
| Rezzani, R | 1 |
| Rodella, LF | 1 |
| Xu, F | 1 |
| Zhao, X | 1 |
| Liu, H | 1 |
| Shao, X | 1 |
| Chu, S | 1 |
| Gong, X | 1 |
| Ma, Z | 1 |
| Gu, X | 1 |
| Kuthati, Y | 1 |
| Lin, SH | 1 |
| Chen, IJ | 1 |
| Wong, CS | 1 |
| Yang, CH | 1 |
| Yip, HK | 1 |
| Chen, HF | 1 |
| Yin, TC | 1 |
| Chiang, JY | 1 |
| Sung, PH | 1 |
| Lin, KC | 1 |
| Tsou, YH | 1 |
| Chen, YL | 1 |
| Li, YC | 1 |
| Huang, TH | 1 |
| Huang, CR | 1 |
| Luo, CW | 1 |
| Chen, KH | 1 |
| Liu, YY | 1 |
| Yin, D | 1 |
| Chen, L | 1 |
| Qu, WM | 1 |
| Chen, CR | 1 |
| Laudon, M | 1 |
| Cheng, NN | 1 |
| Urade, Y | 1 |
| Huang, ZL | 1 |
| Landis, CA | 1 |
| Chiang, RP | 2 |
| Chen, CL | 1 |
| Wang, S | 2 |
| Zhang, L | 1 |
| Lim, G | 2 |
| Sung, B | 2 |
| Tian, Y | 1 |
| Chou, CW | 1 |
| Hernstadt, H | 1 |
| Rusanescu, G | 1 |
| Ma, Y | 1 |
| Mao, J | 3 |
| Lin, JP | 1 |
| Xia, YH | 1 |
| Zhao, H | 1 |
| Kumar, A | 1 |
| Meena, S | 1 |
| Kalonia, H | 1 |
| Gupta, A | 1 |
| Kumar, P | 1 |
| Somera-Molina, KC | 1 |
| Hudson, RL | 1 |
| Dubocovich, ML | 1 |
| Zeng, Q | 1 |
| Yang, L | 1 |
| Chang, Y | 1 |
| Lim, JA | 1 |
| Guo, G | 1 |
| Almay, BG | 1 |
| von Knorring, L | 1 |
| Wetterberg, L | 1 |
2 reviews available for melatonin and Neuralgia
| Article | Year |
|---|---|
Melatonin and their analogs as a potential use in the management of Neuropathic pain.
Topics: Analgesics; Animals; Drug Evaluation, Preclinical; Humans; Melatonin; Neuralgia; Receptor, Melatonin | 2019 |
Targeting Melatonin MT2 Receptors: A Novel Pharmacological Avenue for Inflammatory and Neuropathic Pain.
Topics: Acetamides; Analgesics; Aniline Compounds; Animals; Brain; Clinical Studies as Topic; Humans; Inflam | 2018 |
28 other studies available for melatonin and Neuralgia
| Article | Year |
|---|---|
Supraspinal melatonin MT
Topics: Analgesics, Opioid; Animals; Enkephalins; Melatonin; Mice; Naloxone; Narcotic Antagonists; Neuralgia | 2022 |
Acute and Chronic Pain Preclinical Models to Study the Analgesic Properties of Melatonergic Compounds.
Topics: Acetamides; Analgesics; Animals; Chronic Pain; Melatonin; Neuralgia | 2022 |
Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Cytokines; Inflammasomes; | 2023 |
Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Interleukin-6; Melatonin; Neuralgia; Ne | 2023 |
Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions.
Topics: Analgesics; Animals; Ganglia, Spinal; Hyperalgesia; Melatonin; Mitochondria; Neuralgia; Rats; Rats, | 2023 |
Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons.
Topics: Animals; Epigenesis, Genetic; Ganglia, Spinal; Hyperalgesia; Melatonin; Neuralgia; Neurons; Rats; Re | 2023 |
Melatonin and Selenium Suppress Docetaxel-Induced TRPV1 Activation, Neuropathic Pain and Oxidative Neurotoxicity in Mice.
Topics: Animals; Calcium; Docetaxel; Male; Melatonin; Mice; Neuralgia; Oxidative Stress; Selenium; TRPM Cati | 2021 |
Melatonin reduces neuropathic pain behavior and glial activation through MT
Topics: Animals; Demyelinating Diseases; Lysophosphatidylcholines; Male; Melatonin; Microinjections; Neuralg | 2020 |
Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Melatonin; Neuralgia; Neuroinflammatory Diseases; Rats; Rats, Sprag | 2021 |
The anti-inflammatory and analgesic effects of intraperitoneal melatonin after spinal nerve ligation are mediated by inhibition of the NF-κB/NLRP3 inflammasome signaling pathway.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dipeptides; Inflammasomes; Male; Melatonin; Neuralgia | 2021 |
Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening.
Topics: Analgesics; Cell Line; Drug Evaluation, Preclinical; Ganglia, Spinal; Humans; Iatrogenic Disease; Me | 2021 |
[Melatonin receptor 2 mediated spinal dorsal horn astrocytes IL-17 inhibition contributes to electroacupuncture analgesia in neuropathic pain rats].
Topics: Animals; Astrocytes; Electroacupuncture; Interleukin-17; Male; Melatonin; Neuralgia; Rats; Rats, Spr | 2021 |
Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice.
Topics: Animals; Behavior, Animal; Cells, Cultured; Ganglia, Spinal; Gene Expression Profiling; Melatonin; M | 2017 |
Melatonin impedes Tet1-dependent mGluR5 promoter demethylation to relieve pain.
Topics: Analgesics; Animals; Demethylation; Dioxygenases; DNA Methylation; Hyperalgesia; Male; Melatonin; Ne | 2017 |
Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Female; Humans; Hyperalg | 2017 |
Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats.
Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Male; Melatoni | 2017 |
Misaligned Feeding May Aggravate Pain by Disruption of Sleep-Awake Rhythm.
Topics: Activity Cycles; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cycl | 2018 |
Long-term Therapeutic Effects of Extracorporeal Shock Wave-Assisted Melatonin Therapy on Mononeuropathic Pain in Rats.
Topics: Animals; Antioxidants; Extracorporeal Shockwave Therapy; Male; Melatonin; Neuralgia; Oxidative Stres | 2019 |
Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Hypnotics and Sedatives; Indoles; Male; M | 2014 |
Is melatonin the next "new" therapy to improve sleep and reduce pain?
Topics: Animals; Male; Median Nerve; Melatonin; Microglia; Neuralgia; Sleep Deprivation | 2014 |
Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion.
Topics: Animals; Cytokines; Inflammation Mediators; Male; Median Nerve; Medulla Oblongata; Melatonin; Microg | 2014 |
A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats.
Topics: Analysis of Variance; Animals; Chronic Disease; Dextromethorphan; Dose-Response Relationship, Drug; | 2009 |
[Effect and possible mechanism of melatonin on the firing rate of pain neurons in lateral habenular nucleus].
Topics: Analgesics; Animals; Habenula; Male; Melatonin; Neuralgia; Neurons; Rats; Rats, Wistar | 2006 |
Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats.
Topics: Animals; Antioxidants; Arginine; Catalase; Chronic Disease; Disease Models, Animal; Glutathione; Hyp | 2011 |
Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus.
Topics: Animals; Blotting, Western; Dentate Gyrus; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; | 2013 |
Melatonin reduces median nerve injury-induced mechanical hypersensitivity via inhibition of microglial p38 mitogen-activated protein kinase activation in rat cuneate nucleus.
Topics: Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Median Ne | 2013 |
Exacerbated mechanical allodynia in rats with depression-like behavior.
Topics: Animals; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Gyrus Cingu | 2008 |
Melatonin in serum and urine in patients with idiopathic pain syndromes.
Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Ne | 1987 |