melatonin has been researched along with Nerve Degeneration in 35 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin is a very potent and efficient endogenous radical scavenger." | 6.38 | Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. ( Chen, LD; Manchester, LC; Poeggeler, B; Reiter, RJ; Tan, DX, 1993) |
| "Leptin is an adipokine secreted in a manner dependent on the circadian rhythm that ultimately reduces food intake." | 5.48 | Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level. ( Bermejo-Millo, JC; Boga, JA; Caballero, B; Coto-Montes, A; de Luxán-Delgado, B; Pérez-Martínez, Z; Potes, Y; Rubio-González, A; Solano, JJ; Vega-Naredo, I, 2018) |
| "Melatonin treatment improved spatial learning and memory and increased the number of choline acetyltransferase (ChAT)-positive cells in the medial septum of both TS and CO mice." | 5.39 | Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. ( Corrales, A; Flórez, J; García, E; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sanchez-Barceló, EJ; Vidal, V, 2013) |
| " Methylprednisolone (MP), by reducing edema and protecting the cell membrane against peroxidation, is the only pharmacological agent with a proven clinically beneficial effect on SCI." | 3.72 | Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury. ( Batcioglu, K; Cayli, SR; Erbil, M; Kocak, A; Ozturk, C; Tekiner, A; Yilmaz, U; Yologlu, S, 2004) |
| "For more than 50 years, Parkinson's disease (PD) has been conceptualized as a product of nigro-striatal dopamine (NSD) system degeneration." | 2.44 | Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process. ( Willis, GL, 2008) |
| "Melatonin is a very potent and efficient endogenous radical scavenger." | 2.38 | Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. ( Chen, LD; Manchester, LC; Poeggeler, B; Reiter, RJ; Tan, DX, 1993) |
| "Leptin is an adipokine secreted in a manner dependent on the circadian rhythm that ultimately reduces food intake." | 1.48 | Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level. ( Bermejo-Millo, JC; Boga, JA; Caballero, B; Coto-Montes, A; de Luxán-Delgado, B; Pérez-Martínez, Z; Potes, Y; Rubio-González, A; Solano, JJ; Vega-Naredo, I, 2018) |
| "Mn-induced neuron degeneration, astrocytes, and microglia activation contribute to the changes of oxidative stress markers." | 1.42 | Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. ( Deng, Y; Jiao, C; Li, Y; Liu, W; Mi, C; Wang, F; Xu, B; Xu, Z, 2015) |
| "Melatonin plays an important role in aging and relevant neurodegeneration as an antioxidant and neuroprotector." | 1.39 | Melatonin premedication attenuates isoflurane anesthesia-induced β-amyloid generation and cholinergic dysfunction in the hippocampus of aged rats. ( Guo, X; Jia, D; Li, M; Luo, A; Ni, C; Qian, M; Tan, G; Tang, Y; Wang, J; Wu, C; Zhang, Y; Zhou, Y, 2013) |
| "Melatonin treatment improved spatial learning and memory and increased the number of choline acetyltransferase (ChAT)-positive cells in the medial septum of both TS and CO mice." | 1.39 | Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. ( Corrales, A; Flórez, J; García, E; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sanchez-Barceló, EJ; Vidal, V, 2013) |
| "Melatonin treatment obviously reduced the deposition of MSSG and elevated hippocampal pyramidal cell number while improving the learning and memory deficits of SAMP8." | 1.35 | Differential effects of melatonin on hippocampal neurodegeneration in different aged accelerated senescence prone mouse-8. ( Cheng, S; Fan, W; He, H; Ma, C; Pang, J; Qu, H, 2008) |
| "Melatonin was found to be superior to octreotide with respect to the prevention of congestion, edema, axonal degeneration and necrosis." | 1.35 | Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. ( Erol, FS; Ilhan, N; Kaplan, M; Ozercan, I; Tiftikci, M; Topsakal, C; Yakar, H, 2008) |
| "Treatment with melatonin in SAMP8 and SAMR1 mice reduced the neurodegenerative changes with an increase of ROR-alpha1 levels without an apparent influence in the levels of MT-1 receptor." | 1.35 | Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice. ( Caballero, B; Camins, A; Coto-Montes, A; De Gonzalo-Calvo, D; Gutierrez-Cuesta, J; Huidobro-Fernández, C; Pallas, M; Rodríguez-Colunga, MJ; Sierra, V; Soria-Valles, C; Tolivia, D; Vega-Naredo, I, 2008) |
| "Melatonin is a potent antioxidant agent and an anti-aging hormone." | 1.34 | Effects of melatonin supplementary on the sciatic nerve conduction velocity in the ovariectomized-aged rat. ( Bilgin, MD; Birincioglu, M; Dost, T; Ek, RO; Zencirci, SG, 2007) |
| "Melatonin treatment failed to alter mRNA levels in either area." | 1.31 | Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus. ( Absi, el-H; Cano, J; Machado, A; Venero, JL, 2002) |
| "Melatonin (10 mg/kg) was administrated intraperitoneally 1 h before and 1, 3, and 5 h after intrastriatal kainate injection in adult Sprague-Dawley rats." | 1.30 | The antioxidant melatonin reduces cortical neuronal death after intrastriatal injection of kainate in the rat. ( Chen, ST; Chuang, JI, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 19 (54.29) | 29.6817 |
| 2010's | 13 (37.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, Y | 1 |
| Guo, X | 2 |
| Han, C | 1 |
| Wan, F | 1 |
| Ma, K | 1 |
| Guo, S | 1 |
| Wang, L | 1 |
| Xia, Y | 1 |
| Liu, L | 1 |
| Lin, Z | 1 |
| Huang, J | 1 |
| Xiong, N | 1 |
| Wang, T | 1 |
| Rubio-González, A | 1 |
| Bermejo-Millo, JC | 2 |
| de Luxán-Delgado, B | 2 |
| Potes, Y | 2 |
| Pérez-Martínez, Z | 2 |
| Boga, JA | 1 |
| Vega-Naredo, I | 3 |
| Caballero, B | 3 |
| Solano, JJ | 2 |
| Coto-Montes, A | 3 |
| Leeboonngam, T | 1 |
| Pramong, R | 1 |
| Sae-Ung, K | 2 |
| Govitrapong, P | 4 |
| Phansuwan-Pujito, P | 2 |
| Guimarães, MRM | 1 |
| Díaz-Luis, A | 1 |
| Sarlak, G | 1 |
| Jenwitheesuk, A | 2 |
| Chetsawang, B | 1 |
| Deng, Y | 1 |
| Jiao, C | 1 |
| Mi, C | 1 |
| Xu, B | 1 |
| Li, Y | 1 |
| Wang, F | 1 |
| Liu, W | 2 |
| Xu, Z | 1 |
| Nopparat, C | 1 |
| Mukda, S | 1 |
| Wongchitrat, P | 1 |
| Lee, S | 1 |
| Park, S | 1 |
| Won, J | 1 |
| Lee, SR | 1 |
| Chang, KT | 1 |
| Hong, Y | 1 |
| Ueda, S | 1 |
| Sakakibara, S | 1 |
| Kadowaki, T | 1 |
| Naitoh, T | 1 |
| Hirata, K | 1 |
| Yoshimoto, K | 1 |
| Willis, GL | 1 |
| Sheth, DS | 1 |
| Tajuddin, NF | 1 |
| Druse, MJ | 1 |
| Atik, B | 1 |
| Erkutlu, I | 1 |
| Tercan, M | 1 |
| Buyukhatipoglu, H | 1 |
| Bekerecioglu, M | 1 |
| Pence, S | 1 |
| Uéda, K | 1 |
| Rosales-Corral, S | 1 |
| Acuna-Castroviejo, D | 1 |
| Tan, DX | 2 |
| López-Armas, G | 1 |
| Cruz-Ramos, J | 1 |
| Munoz, R | 1 |
| Melnikov, VG | 1 |
| Manchester, LC | 2 |
| Reiter, RJ | 3 |
| Ni, C | 1 |
| Tan, G | 1 |
| Luo, A | 1 |
| Qian, M | 1 |
| Tang, Y | 1 |
| Zhou, Y | 1 |
| Wang, J | 1 |
| Li, M | 1 |
| Zhang, Y | 1 |
| Jia, D | 1 |
| Wu, C | 1 |
| Corrales, A | 1 |
| Martínez, P | 1 |
| García, S | 1 |
| Vidal, V | 1 |
| García, E | 1 |
| Flórez, J | 1 |
| Sanchez-Barceló, EJ | 1 |
| Martínez-Cué, C | 1 |
| Rueda, N | 1 |
| Rival, T | 1 |
| Soustelle, L | 1 |
| Strambi, C | 1 |
| Besson, MT | 1 |
| Iché, M | 1 |
| Birman, S | 2 |
| Cayli, SR | 1 |
| Kocak, A | 1 |
| Yilmaz, U | 1 |
| Tekiner, A | 1 |
| Erbil, M | 1 |
| Ozturk, C | 1 |
| Batcioglu, K | 1 |
| Yologlu, S | 1 |
| Coulom, H | 1 |
| Nam, E | 1 |
| Lee, SM | 1 |
| Koh, SE | 1 |
| Joo, WS | 1 |
| Maeng, S | 1 |
| Im, HI | 1 |
| Kim, YS | 1 |
| Baydas, G | 1 |
| Tuzcu, M | 1 |
| Abd-Elghaffar, SKh | 1 |
| El-Sokkary, GH | 1 |
| Sharkawy, AA | 1 |
| Yon, JH | 1 |
| Carter, LB | 1 |
| Jevtovic-Todorovic, V | 1 |
| Herrera, F | 1 |
| Martin, V | 1 |
| García-Santos, G | 1 |
| Rodriguez-Blanco, J | 1 |
| Antolín, I | 1 |
| Rodriguez, C | 1 |
| Ek, RO | 1 |
| Zencirci, SG | 1 |
| Dost, T | 1 |
| Birincioglu, M | 1 |
| Bilgin, MD | 1 |
| Cheng, S | 1 |
| Ma, C | 1 |
| Qu, H | 1 |
| Fan, W | 1 |
| Pang, J | 1 |
| He, H | 1 |
| Erol, FS | 1 |
| Kaplan, M | 1 |
| Tiftikci, M | 1 |
| Yakar, H | 1 |
| Ozercan, I | 1 |
| Ilhan, N | 1 |
| Topsakal, C | 1 |
| Sierra, V | 1 |
| Huidobro-Fernández, C | 1 |
| Soria-Valles, C | 1 |
| De Gonzalo-Calvo, D | 1 |
| Tolivia, D | 1 |
| Gutierrez-Cuesta, J | 1 |
| Pallas, M | 1 |
| Camins, A | 1 |
| Rodríguez-Colunga, MJ | 1 |
| Poeggeler, B | 1 |
| Chen, LD | 1 |
| Chen, ST | 1 |
| Chuang, JI | 1 |
| Lin, AM | 1 |
| Chyi, BY | 1 |
| Wang, SD | 1 |
| Yu, HH | 1 |
| Kanakamma, PP | 1 |
| Luh, TY | 1 |
| Chou, CK | 1 |
| Ho, LT | 1 |
| Espinar, A | 1 |
| García-Oliva, A | 1 |
| Isorna, EM | 1 |
| Quesada, A | 1 |
| Prada, FA | 1 |
| Guerrero, JM | 1 |
| Chang, HM | 1 |
| Ling, EA | 1 |
| Lue, JH | 1 |
| Wen, CY | 1 |
| Shieh, JY | 1 |
| Møller, M | 1 |
| Venero, JL | 1 |
| Absi, el-H | 1 |
| Cano, J | 1 |
| Machado, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432] | Phase 2 | 40 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for melatonin and Nerve Degeneration
| Article | Year |
|---|---|
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Circadian Clocks; Dopamine; Dopaminergic Neurons; Genetic Predisposition t | 2017 |
Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration.
Topics: Aged; Aging; Animals; Apoptosis; Cognition Disorders; Humans; Melatonin; Nerve Degeneration; Neural | 2013 |
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Topics: Aging; Animals; Autophagy; Brain; Caloric Restriction; Circadian Rhythm; Diabetes Mellitus; Energy M | 2014 |
The Incremental Induction of Neuroprotective Properties by Multiple Therapeutic Strategies for Primary and Secondary Neural Injury.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Drug Therapy, Combination; Humans; Melatonin | 2015 |
Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process.
Topics: Animals; Circadian Rhythm; Dopamine; Endocrine System Diseases; Humans; Melatonin; Nerve Degeneratio | 2008 |
Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis.
Topics: Aging; Animals; Calcium; Free Radical Scavengers; Free Radicals; Glutamates; Glutamic Acid; Humans; | 1993 |
29 other studies available for melatonin and Nerve Degeneration
| Article | Year |
|---|---|
Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.
Topics: Animals; Autophagy; Behavior, Animal; Biomarkers; Body Weight; Brain; Cytokines; Endoplasmic Reticul | 2018 |
Neuroprotective effects of melatonin on amphetamine-induced dopaminergic fiber degeneration in the hippocampus of postnatal rats.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Dopaminergic Neurons; Hippocampus; Melatoni | 2018 |
High-Fructose Consumption Impairs the Redox System and Protein Quality Control in the Brain of Syrian Hamsters: Therapeutic Effects of Melatonin.
Topics: Animals; Biomarkers; Blood Glucose; Brain; Cricetinae; Diet; Fructose; Homeostasis; Lipid Peroxidati | 2018 |
Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration.
Topics: Animals; Antioxidants; Apoptosis; CD11b Antigen; Chlorides; Dopamine; Dopamine Plasma Membrane Trans | 2015 |
Chronic treatment with melatonin attenuates serotonergic degeneration in the striatum and olfactory tubercle of zitter mutant rats.
Topics: Aging; Animals; Antioxidants; Chromatography, High Pressure Liquid; Corpus Striatum; Immunohistochem | 2008 |
Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 cells.
Topics: Acetylcysteine; Alcohol-Induced Disorders, Nervous System; Animals; Antioxidants; Apoptosis; Apoptos | 2009 |
The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats.
Topics: Action Potentials; Animals; Antioxidants; Collagen; Disease Models, Animal; Female; Melatonin; Motor | 2011 |
Melatonin reduces the expression of alpha-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats.
Topics: alpha-Synuclein; Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Brain; Dopamine; Mela | 2012 |
Accumulation of exogenous amyloid-beta peptide in hippocampal mitochondria causes their dysfunction: a protective role for melatonin.
Topics: Adenosine Triphosphatases; Amyloid beta-Peptides; Animals; Axons; Cell Respiration; Cholesterol; Ext | 2012 |
Melatonin premedication attenuates isoflurane anesthesia-induced β-amyloid generation and cholinergic dysfunction in the hippocampus of aged rats.
Topics: Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Antioxidants; Choline O-Acetyltransferase; | 2013 |
Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome.
Topics: Administration, Oral; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, Anima | 2013 |
Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain.
Topics: Animals; Brain; DNA Primers; Drosophila; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Tr | 2004 |
Effect of combined treatment with melatonin and methylprednisolone on neurological recovery after experimental spinal cord injury.
Topics: Animals; Axons; Disease Models, Animal; Drug Therapy, Combination; Edema; Evoked Potentials, Motor; | 2004 |
Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster.
Topics: Animals; Antioxidants; Apoptosis; Brain; Cell Count; Dopamine; Dopamine Agonists; Drosophila melanog | 2004 |
Melatonin protects against neuronal damage induced by 3-nitropropionic acid in rat striatum.
Topics: Analysis of Variance; Animals; Antioxidants; Cell Death; Corpus Striatum; Lipid Peroxidation; Male; | 2005 |
Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats.
Topics: Age Factors; Aging; Alcohol-Induced Disorders, Nervous System; Animals; Biomarkers; Cerebral Cortex; | 2005 |
Aluminum-induced neurotoxicity and oxidative damage in rabbits: protective effect of melatonin.
Topics: Aluminum; Animals; Antioxidants; Apoptosis; Brain; Lipid Peroxidation; Male; Malondialdehyde; Melato | 2005 |
Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain.
Topics: Anesthetics, General; Animals; Apoptosis; bcl-X Protein; Blotting, Western; Brain; Caspase 3; Caspas | 2006 |
Melatonin prevents glutamate-induced oxytosis in the HT22 mouse hippocampal cell line through an antioxidant effect specifically targeting mitochondria.
Topics: Animals; Antioxidants; Cell Death; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Aci | 2007 |
Effects of melatonin supplementary on the sciatic nerve conduction velocity in the ovariectomized-aged rat.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Estradiol; Female; Melatonin; Nerve | 2007 |
Differential effects of melatonin on hippocampal neurodegeneration in different aged accelerated senescence prone mouse-8.
Topics: Aging; Animals; Antioxidants; Disease Models, Animal; Heredodegenerative Disorders, Nervous System; | 2008 |
Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration | 2008 |
Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice.
Topics: Aging; Aging, Premature; alpha-Synuclein; Animals; Antioxidants; Brain; Lewy Bodies; Melatonin; Mice | 2008 |
The antioxidant melatonin reduces cortical neuronal death after intrastriatal injection of kainate in the rat.
Topics: Animals; Antioxidants; Apoptosis; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Agonists; | 1999 |
Carboxyfullerene prevents iron-induced oxidative stress in rat brain.
Topics: Animals; Antioxidants; Brain Chemistry; Carbon; Chromatography, High Pressure Liquid; Corpus Striatu | 1999 |
Neuroprotection by melatonin from glutamate-induced excitotoxicity during development of the cerebellum in the chick embryo.
Topics: Animals; Cell Death; Cerebellar Cortex; Chick Embryo; Melatonin; Nerve Degeneration; Neuroprotective | 2000 |
Melatonin attenuates neuronal NADPH-d/NOS expression in the hypoglossal nucleus of adult rats following peripheral nerve injury.
Topics: Animals; Axotomy; Cell Count; Cell Death; Hypoglossal Nerve; Male; Melatonin; Motor Neurons; NADPH D | 2000 |
Innervation of the rat pineal gland by PACAP-immunoreactive nerve fibers originating in the trigeminal ganglion: a degeneration study.
Topics: Animals; Antibodies, Monoclonal; Ganglionectomy; Male; Maxillary Nerve; Melatonin; Nerve Degeneratio | 2000 |
Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus.
Topics: Animals; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glutamate Decarboxylase; Hypothalamu | 2002 |