melatonin has been researched along with Narcolepsy in 18 studies
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil is an alerting substance which has been used successfully to treat narcolepsy." | 5.08 | Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation. ( Bastuji, H; Boissy, I; Brun, J; Chamba, G; Claustrat, B; Girard, P; Khalfallah, Y; Sassolas, G, 1998) |
| " Narcolepsy, which is characterized by daytime sleepiness and irresistible episodes of sleep, is treated by an alpha1 noradrenergic stimulant modafinil which has no amphetaminic properties." | 4.84 | [Sleep and wakefulness drugs and their indications]. ( Bourin, M, 2007) |
| "While some sleep disorders are more challenging to treat, most can be easily managed with adequate interventions." | 2.61 | Sleep Disorders. ( K Pavlova, M; Latreille, V, 2019) |
| "There are specific sleep disorders (other than insomnia) for which pharmacotherapy plus behavioral strategies are warranted." | 2.46 | Pharmacotherapy in pediatric sleep disorders. ( Garbutt, A; Weiss, SK, 2010) |
| "Narcolepsy is characterized, beside other features, by excessive daytime sleepiness and disturbed sleep at night." | 1.35 | Circadian rhythm in salivary melatonin in narcoleptic patients. ( Blazejova, K; Hajek, I; Illnerova, H; Nevsimalova, S, 2008) |
| "Effective treatments now exist for many sleep disorders, such as OSA and RLS, and a major breakthrough in the treatment of narcolepsy seems imminent." | 1.32 | Sleep disorders. ( Fisch, BJ; Olejniczak, PW, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| K Pavlova, M | 1 |
| Latreille, V | 1 |
| Barun, B | 1 |
| Gringras, P | 1 |
| Billiard, M | 1 |
| Weiss, SK | 1 |
| Garbutt, A | 1 |
| Donjacour, CE | 1 |
| Kalsbeek, A | 1 |
| Overeem, S | 1 |
| Lammers, GJ | 1 |
| Pévet, P | 1 |
| Bothorel, B | 1 |
| Pijl, H | 1 |
| Aziz, NA | 1 |
| Nevsímalová, S | 2 |
| Blazejová, K | 2 |
| Illnerová, H | 2 |
| Hájek, I | 2 |
| Vanková, J | 1 |
| Pretl, M | 1 |
| Sonka, K | 1 |
| Olejniczak, PW | 1 |
| Fisch, BJ | 1 |
| Kunz, D | 1 |
| Mahlberg, R | 1 |
| Müller, C | 1 |
| Tilmann, A | 1 |
| Bes, F | 1 |
| Jordan, W | 1 |
| Tumani, H | 1 |
| Cohrs, S | 1 |
| Rodenbeck, A | 1 |
| Rüther, E | 1 |
| Bechthold, J | 1 |
| Mayer, G | 1 |
| Bourin, M | 1 |
| Pavel, S | 1 |
| Goldstein, R | 1 |
| Petrescu, M | 1 |
| Brun, J | 1 |
| Chamba, G | 1 |
| Khalfallah, Y | 1 |
| Girard, P | 1 |
| Boissy, I | 1 |
| Bastuji, H | 1 |
| Sassolas, G | 1 |
| Claustrat, B | 1 |
| Sandyk, R | 1 |
| Alvarez, B | 1 |
| Dahlitz, MJ | 1 |
| Vignau, J | 1 |
| Parkes, JD | 1 |
| Hajek, M | 1 |
| Meier-Ewert, K | 1 |
| Wirz-Justice, A | 1 |
| Tobler, I | 1 |
| Arendt, J | 1 |
| Dick, H | 1 |
| Fink, G | 1 |
| Schwartz, WJ | 1 |
| Morton, MT | 1 |
| Williams, RS | 1 |
| Tamarkin, L | 1 |
| Baker, TL | 1 |
| Dement, WC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Influence of an Osteopathic Treatment Protocol on the Improvement of Sleep: a Double-blind Randomized Controlled Trial[NCT05899972] | 50 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for melatonin and Narcolepsy
| Article | Year |
|---|---|
Sleep Disorders.
Topics: Central Nervous System Depressants; Central Nervous System Stimulants; Chronobiology Disorders; Cogn | 2019 |
Pathophysiological background and clinical characteristics of sleep disorders in multiple sclerosis.
Topics: Animals; Fatigue; Humans; Melatonin; Multiple Sclerosis; Narcolepsy; Restless Legs Syndrome; Sleep W | 2013 |
When to use drugs to help sleep.
Topics: Child; Humans; Hypnotics and Sedatives; Melatonin; Narcolepsy; Parasomnias; Sleep Initiation and Mai | 2008 |
REM sleep behavior disorder and narcolepsy.
Topics: Antidepressive Agents; Cataplexy; Clonazepam; Humans; Melatonin; Narcolepsy; Polysomnography; Preval | 2009 |
Pharmacotherapy in pediatric sleep disorders.
Topics: Adolescent; Central Nervous System Depressants; Child; GABA-A Receptor Agonists; Histamine Antagonis | 2010 |
[Sleep and wakefulness drugs and their indications].
Topics: Benzhydryl Compounds; Benzodiazepines; Central Nervous System Stimulants; Humans; Hypnotics and Seda | 2007 |
2 trials available for melatonin and Narcolepsy
| Article | Year |
|---|---|
Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.
Topics: Adult; Aged; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Melatonin; Middle Aged; Na | 2004 |
Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation.
Topics: Adult; Benzhydryl Compounds; Body Temperature; Central Nervous System Stimulants; Health Status; Hum | 1998 |
10 other studies available for melatonin and Narcolepsy
| Article | Year |
|---|---|
Altered circadian rhythm of melatonin concentrations in hypocretin-deficient men.
Topics: Adult; Case-Control Studies; Circadian Rhythm; Humans; Intracellular Signaling Peptides and Proteins | 2012 |
A contribution to pathophysiology of idiopathic hypersomnia.
Topics: Adolescent; Adult; Child; Circadian Rhythm; Female; Humans; Hydrocortisone; Idiopathic Hypersomnia; | 2000 |
Sleep disorders.
Topics: Adult; Aged; Antioxidants; Cheyne-Stokes Respiration; Chronobiology Disorders; Chronotherapy; Disord | 2003 |
Narcolepsy increased L-PGDS (beta-trace) levels correlate with excessive daytime sleepiness but not with cataplexy.
Topics: Adolescent; Adult; Aged; Circadian Rhythm; Female; Humans; Intramolecular Oxidoreductases; Lipocalin | 2005 |
Circadian rhythm in salivary melatonin in narcoleptic patients.
Topics: Adult; Biomarkers; Child; Chronobiology Disorders; Circadian Rhythm; Female; Humans; Male; Melatonin | 2008 |
Vasotocin, melatonin and narcolepsy: possible involvement of the pineal gland in its patho-physiological mechanism.
Topics: Adolescent; Adult; Circadian Rhythm; Humans; Male; Melatonin; Narcolepsy; Pineal Gland; Sleep, REM; | 1980 |
Melatonin and maturation of REM sleep.
Topics: Body Temperature; Brain; Circadian Rhythm; Electroencephalography; Female; Humans; Hypothalamus; Inf | 1992 |
The delayed sleep phase syndrome: clinical and investigative findings in 14 subjects.
Topics: Adolescent; Adult; Aged; Behavior Therapy; Cataplexy; Circadian Rhythm; Combined Modality Therapy; F | 1992 |
Bright white light does not improve narcoleptic symptoms.
Topics: Aged; Circadian Rhythm; Female; Humans; Hydrocortisone; Male; Melatonin; Middle Aged; Narcolepsy; Ph | 1989 |
Circadian timekeeping in narcoleptic dogs.
Topics: Animals; Circadian Rhythm; Dogs; Hypothalamus; Male; Melatonin; Narcolepsy; Neural Pathways; Retina; | 1986 |