melatonin has been researched along with Mucositis in 4 studies
Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mucositis is one of the most adverse effects of 5-fluorouracil (5-FU) and had no standard drug for treatment." | 8.02 | Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-Induced Small Intestinal Mucositis Treatment in Mice. ( Boonsiri, P; Chio-Srichan, S; Daduang, J; Lee, YC; Leelayuwat, C; Mahakunakorn, P; Priprem, A; Puthongking, P; Settasatian, C; Tippayawat, P; Uthaiwat, P, 2021) |
| " Included studies showed a statistically significant improvement in mucositis severity score for all antioxidants except melatonin." | 5.22 | Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses. ( Al-Eryani, K; Emperumal, CP; Enciso, R; Karimyan, N; Raza, A; Watters, A, 2022) |
| "Mucositis is one of the most adverse effects of 5-fluorouracil (5-FU) and had no standard drug for treatment." | 4.02 | Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-Induced Small Intestinal Mucositis Treatment in Mice. ( Boonsiri, P; Chio-Srichan, S; Daduang, J; Lee, YC; Leelayuwat, C; Mahakunakorn, P; Priprem, A; Puthongking, P; Settasatian, C; Tippayawat, P; Uthaiwat, P, 2021) |
| "Inflammation is mediated by various genes and cytokines related to immune system responses caused by massive cell death following radiotherapy." | 2.55 | Melatonin as an anti-inflammatory agent in radiotherapy. ( Motevaseli, E; Najafi, M; Rezaeyan, AH; Rezapoor, S; Salajegheh, A; Shirazi, A, 2017) |
| "Pretreatment with melatonin had a dose-dependent protective effect on methotrexate (MTX)-induced alterations in small intestinal morphology." | 1.39 | Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats. ( Abraham, P; Isaac, B; Kasthuri, N; Kolli, VK, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raza, A | 1 |
| Karimyan, N | 1 |
| Watters, A | 1 |
| Emperumal, CP | 1 |
| Al-Eryani, K | 1 |
| Enciso, R | 1 |
| Uthaiwat, P | 1 |
| Priprem, A | 1 |
| Chio-Srichan, S | 1 |
| Settasatian, C | 1 |
| Lee, YC | 1 |
| Mahakunakorn, P | 1 |
| Boonsiri, P | 1 |
| Leelayuwat, C | 1 |
| Tippayawat, P | 1 |
| Puthongking, P | 1 |
| Daduang, J | 1 |
| Najafi, M | 1 |
| Shirazi, A | 1 |
| Motevaseli, E | 1 |
| Rezaeyan, AH | 1 |
| Salajegheh, A | 1 |
| Rezapoor, S | 1 |
| Kolli, VK | 1 |
| Abraham, P | 1 |
| Isaac, B | 1 |
| Kasthuri, N | 1 |
2 reviews available for melatonin and Mucositis
| Article | Year |
|---|---|
Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses.
Topics: Adult; Antioxidants; Curcumin; Head and Neck Neoplasms; Humans; Melatonin; Mucositis; Propolis; Sily | 2022 |
Melatonin as an anti-inflammatory agent in radiotherapy.
Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Humans; Inflammation; Melatonin; Mucositis; Neoplasms | 2017 |
2 other studies available for melatonin and Mucositis
| Article | Year |
|---|---|
Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-Induced Small Intestinal Mucositis Treatment in Mice.
Topics: Administration, Oral; Animals; Fluorouracil; Interleukin-1beta; Intestinal Mucosa; Intestine, Small; | 2021 |
Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Dose-Response Relationship, Drug; Drug Evalu | 2013 |