Page last updated: 2024-10-19

melatonin and Metastase

melatonin has been researched along with Metastase in 53 studies

Research Excerpts

ExcerptRelevanceReference
"Recent observations have shown that the pineal hormone melatonin (MLT) may modulate oestrogen receptor (ER) expression and inhibit breast cancer cell growth."9.08Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone. ( Barni, S; Cazzaniga, M; Esposti, D; Fossati, V; Lissoni, P; Meregalli, S; Tancini, G, 1995)
"This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular, dietary, and metabolic signaling mechanisms involved in human breast cancer growth and the consequences of circadian disruption by exposure to light at night (LAN)."8.87Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. ( Blask, DE; Dauchy, E; Dauchy, RT; Duplessis, T; Hill, SM; Mao, L; Sauer, LA; Xiang, S; Yuan, L, 2011)
"Melatonin exerts oncostatic effects on breast cancer via immunomodulation and antioxidation."8.12Effects of Melatonin and Doxorubicin on Primary Tumor And Metastasis in Breast Cancer Model. ( Aytac, G; Dilmac, S; Farooqi, AA; Sindel, M; Tanriover, G, 2022)
"MTT, wound healing, transwell assay and western blotting were conducted to determine the effect of melatonin on osteosarcoma cell invasion and migration and downregulation of SOX9-mediated signaling."7.88Melatonin inhibits osteosarcoma stem cells by suppressing SOX9-mediated signaling. ( Fu, Q; He, J; Lai, L; Lian, W; Lin, N; Qu, H; Wang, C; Wang, Q; Xue, Y; Ye, Z; Zhong, L, 2018)
"Melatonin inhibition of Rsk2 represses the metastatic phenotype in breast cancer cells suppressing EMT or inhibiting other mechanisms that promote metastasis; disruption of the melatonin signal may promote metastatic progression in breast cancer."7.83Melatonin Represses Metastasis in Her2-Postive Human Breast Cancer Cells by Suppressing RSK2 Expression. ( Blask, DE; Dauchy, RT; Frasch, T; Hill, SM; Mao, L; Pointer, D; Reynolds, A; Summers, W; Wren-Dail, MA; Xiang, S; Yuan, L, 2016)
"Daytime plasma melatonin values were measured by radioimmune assay in 86 patients with breast cancer; 280 assays were done and compared with the clinical status of the patients."7.68Plasma melatonin in patients with breast cancer. ( Falkson, G; Falkson, HC; Meyer, BJ; Rapoport, BL; Steyn, ME, 1990)
"Since there is no effective second line chemotherapy in colorectal cancer resistant to fluorouracil, this study was carried out to evaluate the therapeutic activity of the pineal hormone melatonin, which has appeared to have antineoplastic activity in some experimental conditions, in patients with metastatic colorectal carcinoma who did not respond to fluorouracil."7.68A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates. ( Archili, C; Barni, S; Crispino, S; Lissoni, P; Paolorossi, F; Tancini, G, 1990)
"Melatonin is an endogenous hormone primarily known for its action on the circadian rhythms."6.58Therapeutic potential of melatonin for breast cancer radiation therapy patients. ( Griffin, F; Marignol, L, 2018)
"5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model."6.505-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014)
"Breast cancer is the most common neoplastic disorder diagnosed in women."5.51Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway. ( El-Sokkary, GH; Ismail, IA; Saber, SH, 2019)
"Melatonin and Y27632 treatments reduced cell viability and invasion/migration of both cell lines and decreased ROCK-1 gene expression in metastatic cells and protein expression in nonmetastatic cell line."5.43Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. ( Arbab, AS; Borin, TF; Coimbra, VB; de Oliveira, JG; Fabri, VA; Ferreira, LC; Gelaleti, GB; Iskander, AS; Jardim-Perassi, BV; Moschetta, MG; Shankar, A; Varma, NR; Zuccari, DA, 2016)
"Three types of human breast cancer cells were used in this study: MDA-MB-435, MDA-MB-231, and MCF-7."5.31Studies of the interactions between melatonin and 2 Hz, 0.3 mT PEMF on the proliferation and invasion of human breast cancer cells. ( Anderson, KW; Leman, ES; Sisken, BF; Zimmer, S, 2001)
"Melatonin was also able to block 17beta-estradiol-induced invasion (P < 0."5.30Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. ( Cos, S; Fernández, R; Güézmes, A; Sánchez-Barceló, EJ, 1998)
"Experimental studies have showed that hepatocellular carcinoma (HCC) cells are susceptible to cytolysis of interleukin (IL)-2-activated lymphocytes."5.29Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Conti, A; Lissoni, P; Maestroni, GJ; Piperno, A; Pozzi, M; Ricci, G; Tancini, G, 1994)
"Recent observations have shown that the pineal hormone melatonin (MLT) may modulate oestrogen receptor (ER) expression and inhibit breast cancer cell growth."5.08Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone. ( Barni, S; Cazzaniga, M; Esposti, D; Fossati, V; Lissoni, P; Meregalli, S; Tancini, G, 1995)
"This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular, dietary, and metabolic signaling mechanisms involved in human breast cancer growth and the consequences of circadian disruption by exposure to light at night (LAN)."4.87Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. ( Blask, DE; Dauchy, E; Dauchy, RT; Duplessis, T; Hill, SM; Mao, L; Sauer, LA; Xiang, S; Yuan, L, 2011)
"Melatonin exerts oncostatic effects on breast cancer via immunomodulation and antioxidation."4.12Effects of Melatonin and Doxorubicin on Primary Tumor And Metastasis in Breast Cancer Model. ( Aytac, G; Dilmac, S; Farooqi, AA; Sindel, M; Tanriover, G, 2022)
"MTT, wound healing, transwell assay and western blotting were conducted to determine the effect of melatonin on osteosarcoma cell invasion and migration and downregulation of SOX9-mediated signaling."3.88Melatonin inhibits osteosarcoma stem cells by suppressing SOX9-mediated signaling. ( Fu, Q; He, J; Lai, L; Lian, W; Lin, N; Qu, H; Wang, C; Wang, Q; Xue, Y; Ye, Z; Zhong, L, 2018)
"Melatonin inhibition of Rsk2 represses the metastatic phenotype in breast cancer cells suppressing EMT or inhibiting other mechanisms that promote metastasis; disruption of the melatonin signal may promote metastatic progression in breast cancer."3.83Melatonin Represses Metastasis in Her2-Postive Human Breast Cancer Cells by Suppressing RSK2 Expression. ( Blask, DE; Dauchy, RT; Frasch, T; Hill, SM; Mao, L; Pointer, D; Reynolds, A; Summers, W; Wren-Dail, MA; Xiang, S; Yuan, L, 2016)
"Daytime plasma melatonin values were measured by radioimmune assay in 86 patients with breast cancer; 280 assays were done and compared with the clinical status of the patients."3.68Plasma melatonin in patients with breast cancer. ( Falkson, G; Falkson, HC; Meyer, BJ; Rapoport, BL; Steyn, ME, 1990)
"Since there is no effective second line chemotherapy in colorectal cancer resistant to fluorouracil, this study was carried out to evaluate the therapeutic activity of the pineal hormone melatonin, which has appeared to have antineoplastic activity in some experimental conditions, in patients with metastatic colorectal carcinoma who did not respond to fluorouracil."3.68A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates. ( Archili, C; Barni, S; Crispino, S; Lissoni, P; Paolorossi, F; Tancini, G, 1990)
"In order to investigate the pineal function and its relation with the hypophysis in human neoplasms, melatonin and GH serum levels were determined in 63 patients, 42 affected by solid tumours and 21 by lymphoma or leukaemia."3.67The clinical significance of melatonin serum determination in oncological patients and its correlations with GH and PRL blood levels. ( Bajetta, E; Bastone, A; di Bella, L; Esposti, D; Esposti, G; Lissoni, P; Mauri, R; Rovelli, F; Sala, R; Viviani, S, 1987)
"Melatonin is a pleotropic molecule with numerous biological activities."2.72Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities. ( Abuawad, A; Alsayed, AR; Daoud, S; Mahmod, AI; Talib, WH, 2021)
"This study shows that cancer neuroimmunotherapy with low-dose IL-2 and the pineal hormone melatonin may prolong survival time and improve the quality of life of patients with metastatic solid tumours who do not respond to conventional therapies."2.68A randomized study of neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin compared to supportive care alone in patients with untreatable metastatic solid tumour. ( Ardizzoia, A; Barni, S; Cazzaniga, M; Fossati, V; Frigerio, F; Lissoni, P; Tancini, G, 1995)
"Melatonin is an indole produced by the pineal gland at night under normal light or dark conditions, and its levels, which are higher in children than in adults, begin to decrease prior to the onset of puberty and continue to decline thereafter."2.66New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence. ( Hsieh, YH; Lin, CW; Lu, KH; Reiter, RJ; Su, SC; Yang, SF, 2020)
"Melatonin is an endogenous hormone primarily known for its action on the circadian rhythms."2.58Therapeutic potential of melatonin for breast cancer radiation therapy patients. ( Griffin, F; Marignol, L, 2018)
"While the emphasis of melatonin/cancer research has been on the role of the indoleamine in restraining breast cancer, this is changing quickly with many cancer types having been shown to be susceptible to inhibition by melatonin."2.55Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis. ( Acuna-Castroviejo, D; Qin, L; Reiter, RJ; Rosales-Corral, SA; Tan, DX; Xu, K; Yang, SF, 2017)
"Melatonin is a pleiotropic anti-cancer molecule that affects malignant cells via multiple mechanisms."2.55Melatonin as a multifunctional anti-cancer molecule: Implications in gastric cancer. ( Abdollahi, M; Asghari, MH; Fallah, M; Ghobadi, E; Moloudizargari, M, 2017)
"Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a gatekeeper of circadian clocks."2.55Cancer metastasis: Mechanisms of inhibition by melatonin. ( Chung, WH; Hsieh, MJ; Reiter, RJ; Su, SC; Yang, SF; Yang, WE, 2017)
"5-MTP blocks cancer cell migration and invasion in vitro and inhibits tumor growth and cancer metastasis in a xenograft model."2.505-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. ( Chang, TC; Cheng, HH; Wu, KK, 2014)
"Sirtuins, enzymes involved in metastasis formation, have also been detected."1.72The role of selected molecular factors in ovarian cancer metastasis. ( Fechner, J; Markowska, A; Markowska, J; Sawicki, W; Zurawski, J, 2022)
"Melatonin was administrated either before or after the injection of 4TLM cells into the mammary pad."1.62Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer. ( Aytac, G; Dilmac, S; Karadas, AK; Tanriover, G, 2021)
"Head and neck squamous cell carcinoma (HNSCC) cells with or without melatonin treatment were used as a research platform."1.62FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis. ( Jensen, C; Lang, L; Loveless, R; Prieto-Dominguez, N; Shay, C; Teng, Y; Xiong, Y, 2021)
"Melatonin has shown anticancer activity in experimental investigations."1.62Melatonin impedes prostate cancer metastasis by suppressing MMP-13 expression. ( Chang, AC; Chen, PC; Chen, SS; Chen, YH; Lai, YW; Lin, LW; Lin, TH; Tai, HC; Tang, CH; Wang, PC; Wang, SW, 2021)
"Remarkably, acidosis-mediated metastasis was significantly alleviated by BMAL1 overexpression in breast cancer cells."1.56Extracellular Acidosis Promotes Metastatic Potency via Decrease of the ( Kim, K; Kim, SK; Kwon, SH; Kwon, YJ; Lee, SH; Park, IC; Park, JW; Park, S; Park, SK; Seo, EB; Ye, SK, 2020)
"Breast cancer is the most common neoplastic disorder diagnosed in women."1.51Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway. ( El-Sokkary, GH; Ismail, IA; Saber, SH, 2019)
"Melatonin and Y27632 treatments reduced cell viability and invasion/migration of both cell lines and decreased ROCK-1 gene expression in metastatic cells and protein expression in nonmetastatic cell line."1.43Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. ( Arbab, AS; Borin, TF; Coimbra, VB; de Oliveira, JG; Fabri, VA; Ferreira, LC; Gelaleti, GB; Iskander, AS; Jardim-Perassi, BV; Moschetta, MG; Shankar, A; Varma, NR; Zuccari, DA, 2016)
"Melatonin IR was found in all SI-NETS."1.43Melatonin Immunoreactivity in Malignant Small Intestinal Neuroendocrine Tumours. ( Ali, A; Cunningham, JL; Janson, ET; Rasmusson, AJ; Söderquist, F; Stridsberg, M, 2016)
"Treatment with melatonin did not demonstrate inhibition of the expression of genes HIF-1α, VEGF and ROCK-1 in line SCC25, which has different molecular characteristics and greater degree of malignancy when compared to the line SCC9."1.40Molecular markers of angiogenesis and metastasis in lines of oral carcinoma after treatment with melatonin. ( Colombo, J; Goncalves, Ndo N; Jardim-Perassi, BV; Lopes, JR; Moschetta, MG; Rodrigues, RV; Zuccari, DA, 2014)
"Histopathology revealed no metastasis in the liver, small intestine and large intestine in any of the animals in the experimental groups; however this process was evident in the lungs and kidneys, being inhibited by melatonin administration."1.39Melatonin effect on the ultrastructure of Ehrlich ascites tumor cells, lifetime and histopathology in Swiss mice. ( Alves, LC; Batista, AP; da Silva, TG; de Medeiros, PL; dos Santos, FA; Teixeira, ÁA; Teixeira, VW, 2013)
"Three types of human breast cancer cells were used in this study: MDA-MB-435, MDA-MB-231, and MCF-7."1.31Studies of the interactions between melatonin and 2 Hz, 0.3 mT PEMF on the proliferation and invasion of human breast cancer cells. ( Anderson, KW; Leman, ES; Sisken, BF; Zimmer, S, 2001)
"Melatonin was also able to block 17beta-estradiol-induced invasion (P < 0."1.30Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. ( Cos, S; Fernández, R; Güézmes, A; Sánchez-Barceló, EJ, 1998)
"Experimental studies have showed that hepatocellular carcinoma (HCC) cells are susceptible to cytolysis of interleukin (IL)-2-activated lymphocytes."1.29Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Conti, A; Lissoni, P; Maestroni, GJ; Piperno, A; Pozzi, M; Ricci, G; Tancini, G, 1994)

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19906 (11.32)18.7374
1990's11 (20.75)18.2507
2000's4 (7.55)29.6817
2010's20 (37.74)24.3611
2020's12 (22.64)2.80

Authors

AuthorsStudies
Tanriover, G2
Dilmac, S2
Aytac, G2
Farooqi, AA1
Sindel, M1
Diamantopoulou, Z1
Castro-Giner, F1
Schwab, FD1
Foerster, C1
Saini, M1
Budinjas, S1
Strittmatter, K1
Krol, I1
Seifert, B1
Heinzelmann-Schwarz, V1
Kurzeder, C1
Rochlitz, C1
Vetter, M1
Weber, WP1
Aceto, N1
Markowska, A1
Sawicki, W1
Zurawski, J1
Fechner, J1
Markowska, J1
Wu, H1
Liu, J1
Yin, Y1
Zhang, D1
Xia, P1
Zhu, G1
Lu, KH1
Lin, CW2
Hsieh, YH2
Su, SC3
Reiter, RJ4
Yang, SF6
Kwon, YJ1
Seo, EB1
Kwon, SH1
Lee, SH1
Kim, SK1
Park, SK1
Kim, K1
Park, S1
Park, IC1
Park, JW1
Ye, SK1
Wen, YC1
Lin, YW2
Chu, CY2
Yang, YC2
Liu, YF1
Hsiao, M2
Lee, WJ2
Chien, MH3
Bu, S1
Wang, Q2
Sun, J1
Li, X1
Gu, T1
Lai, D1
Wang, SW1
Tai, HC1
Tang, CH1
Lin, LW1
Lin, TH1
Chang, AC1
Chen, PC1
Chen, YH1
Wang, PC1
Lai, YW1
Chen, SS1
Banerjee, V1
Sharda, N1
Huse, J1
Singh, D1
Sokolov, D1
Czinn, SJ1
Blanchard, TG1
Banerjee, A1
Lang, L1
Xiong, Y1
Prieto-Dominguez, N1
Loveless, R1
Jensen, C1
Shay, C1
Teng, Y1
Karadas, AK1
Talib, WH1
Alsayed, AR1
Abuawad, A1
Daoud, S1
Mahmod, AI1
Rosales-Corral, SA1
Tan, DX1
Acuna-Castroviejo, D1
Qin, L1
Xu, K1
Picardo, M1
Slominski, AT1
Asghari, MH1
Moloudizargari, M1
Ghobadi, E1
Fallah, M1
Abdollahi, M1
Griffin, F1
Marignol, L1
Qu, H1
Xue, Y1
Lian, W1
Wang, C1
He, J1
Fu, Q1
Zhong, L1
Lin, N1
Lai, L1
Ye, Z1
Bondy, SC1
Campbell, A1
El-Sokkary, GH1
Ismail, IA1
Saber, SH1
Batista, AP1
da Silva, TG1
Teixeira, ÁA1
de Medeiros, PL1
Teixeira, VW1
Alves, LC1
dos Santos, FA1
Wu, KK1
Cheng, HH1
Chang, TC1
Goncalves, Ndo N1
Rodrigues, RV1
Jardim-Perassi, BV2
Moschetta, MG2
Lopes, JR1
Colombo, J1
Zuccari, DA2
Borin, TF1
Arbab, AS1
Gelaleti, GB1
Ferreira, LC1
Iskander, AS1
Varma, NR1
Shankar, A1
Coimbra, VB1
Fabri, VA1
de Oliveira, JG1
Mao, L3
Dauchy, RT3
Blask, DE3
Dauchy, EM1
Slakey, LM1
Brimer, S1
Yuan, L3
Xiang, S3
Hauch, A1
Smith, K1
Frasch, T2
Belancio, VP1
Wren, MA1
Hill, SM3
Lee, LM1
Tan, P1
Chen, WY1
Summers, W1
Reynolds, A1
Wren-Dail, MA1
Pointer, D1
Ho, HY1
Hsieh, MJ1
Yang, WE1
Chung, WH1
Söderquist, F1
Janson, ET1
Rasmusson, AJ1
Ali, A1
Stridsberg, M1
Cunningham, JL1
Duplessis, T1
Dauchy, E1
Sauer, LA1
Mazzoccoli, G1
Sothern, RB1
Parrella, P1
Muscarella, LA1
Fazio, VM1
Giuliani, F1
Polyakova, V1
Kvetnoy, IM1
Lissoni, P12
Chilelli, M2
Villa, S1
Cerizza, L1
Tancini, G10
WURTMAN, RJ1
AXELROD, J1
Anisimov, VN1
Barni, S9
Fossati, V2
Ardizzoia, A6
Cazzaniga, M2
Frigerio, F1
Meregalli, S1
Esposti, D3
Aldeghi, R1
Piperno, A1
Pozzi, M1
Ricci, G1
Conti, A1
Maestroni, GJ2
Neri, B1
Fiorelli, C1
Moroni, F1
Nicita, G1
Paoletti, MC1
Ponchietti, R1
Raugei, A1
Santoni, G1
Trippitelli, A1
Grechi, G1
Paolorossi, F5
Brivio, F2
Zubelewicz, B1
Chatikhine, V1
Cos, S2
Fernández, R1
Güézmes, A1
Sánchez-Barceló, EJ2
Leman, ES1
Sisken, BF1
Zimmer, S1
Anderson, KW1
Garcia-Bolado, A1
Raĭkhlin, NT1
Kvetnoĭ, IM1
Tisi, E2
Rovelli, F2
Rescaldani, R1
Ballabio, D1
Benenti, C1
Angeli, M1
Crispino, S3
Archili, C2
De Toma, D1
Pipino, G1
Falkson, G1
Falkson, HC1
Steyn, ME1
Rapoport, BL1
Meyer, BJ1
Cattaneo, G1
Lucini, V1
Mariani, M1
Esposti, G2
Bastone, A1
Sala, R1
Mauri, R1
Viviani, S1
Bajetta, E1
di Bella, L1
Greisheimer, EM1

Reviews

12 reviews available for melatonin and Metastase

ArticleYear
Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action.
    BioMed research international, 2019, Volume: 2019

    Topics: Apoptosis; Autophagy; Cell Proliferation; Circadian Rhythm; Colorectal Neoplasms; Gastrointestinal T

2019
New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence.
    Cancer metastasis reviews, 2020, Volume: 39, Issue:1

    Topics: Adolescent; Animals; Bone Neoplasms; Child; Humans; Melatonin; Muscle Neoplasms; Neoplasm Invasivene

2020
Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.
    Molecules (Basel, Switzerland), 2021, Apr-25, Volume: 26, Issue:9

    Topics: Apoptosis; Cell Proliferation; Drug-Related Side Effects and Adverse Reactions; Humans; Melatonin; N

2021
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.
    International journal of molecular sciences, 2017, Apr-17, Volume: 18, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation,

2017
Melatonin as a multifunctional anti-cancer molecule: Implications in gastric cancer.
    Life sciences, 2017, Sep-15, Volume: 185

    Topics: Animals; Antineoplastic Agents; Humans; Melatonin; Neoplasm Metastasis; Neovascularization, Patholog

2017
Therapeutic potential of melatonin for breast cancer radiation therapy patients.
    International journal of radiation biology, 2018, Volume: 94, Issue:5

    Topics: Animals; Breast Neoplasms; Dose-Response Relationship, Radiation; Estrogen Receptor alpha; Female; H

2018
Mechanisms Underlying Tumor Suppressive Properties of Melatonin.
    International journal of molecular sciences, 2018, Jul-27, Volume: 19, Issue:8

    Topics: Aging; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogenesis; Disease Models, Animal; Disea

2018
5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.
    Journal of biomedical science, 2014, Mar-03, Volume: 21

    Topics: Carcinogenesis; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Indoles; Inflammat

2014
Cancer metastasis: Mechanisms of inhibition by melatonin.
    Journal of pineal research, 2017, Volume: 62, Issue:1

    Topics: Animals; Humans; Melatonin; Neoplasm Metastasis

2017
Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night.
    Journal of pineal research, 2011, Volume: 51, Issue:3

    Topics: Breast Neoplasms; Cell Proliferation; Circadian Rhythm; Diet; Female; Gene Expression Regulation, Ne

2011
[Epiphysis (pineal gland) and tumorous growth].
    Voprosy onkologii, 1980, Volume: 26, Issue:8

    Topics: Adjuvants, Immunologic; Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Cell Transformatio

1980
The pineal gland.
    Journal of the American Medical Women's Association, 1968, Volume: 23, Issue:3

    Topics: Animals; Biological Clocks; Cattle; Chemoreceptor Cells; Humans; Light; Mast Cells; Melatonin; Neopl

1968

Trials

9 trials available for melatonin and Metastase

ArticleYear
Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial.
    Journal of pineal research, 2003, Volume: 35, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antioxidants; Carcinoma, Non-Small-Cell Lung;

2003
A randomized study of neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin compared to supportive care alone in patients with untreatable metastatic solid tumour.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1995, Volume: 3, Issue:3

    Topics: Administration, Oral; Adult; Aged; Drug Therapy, Combination; Female; Hospice Care; Humans; Immunoth

1995
Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone.
    British journal of cancer, 1995, Volume: 71, Issue:4

    Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Insulin-Like Growth Factor I; Melatonin; Middle Aged;

1995
Modulation of human lymphoblastoid interferon activity by melatonin in metastatic renal cell carcinoma. A phase II study.
    Cancer, 1994, Jun-15, Volume: 73, Issue:12

    Topics: Adult; Aged; Carcinoma, Renal Cell; Female; Humans; Interferon-alpha; Kidney Neoplasms; Male; Melato

1994
Is there a role for melatonin in the treatment of neoplastic cachexia?
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:8

    Topics: Adult; Aged; Cachexia; Female; Humans; Male; Melatonin; Middle Aged; Neoplasm Metastasis; Palliative

1996
A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients.
    British journal of cancer, 1996, Volume: 74, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherap

1996
Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms.
    Annals of the New York Academy of Sciences, 2000, Volume: 917

    Topics: 5-Methoxytryptamine; Antineoplastic Combined Chemotherapy Protocols; Humans; Immunotherapy; Indoles;

2000
Biological and clinical results of a neuroimmunotherapy with interleukin-2 and the pineal hormone melatonin as a first line treatment in advanced non-small cell lung cancer.
    British journal of cancer, 1992, Volume: 66, Issue:1

    Topics: Biopterins; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Drug Administration Schedule;

1992
Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first-line chemotherapy containing cisplatin.
    Oncology, 1992, Volume: 49, Issue:5

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Resistance; Humans; Lung Neoplasms; Mel

1992

Other Studies

32 other studies available for melatonin and Metastase

ArticleYear
Effects of Melatonin and Doxorubicin on Primary Tumor And Metastasis in Breast Cancer Model.
    Anti-cancer agents in medicinal chemistry, 2022, Volume: 22, Issue:10

    Topics: Animals; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Female; Humans; Melatonin

2022
The metastatic spread of breast cancer accelerates during sleep.
    Nature, 2022, Volume: 607, Issue:7917

    Topics: Animals; Breast Neoplasms; Cell Count; Cell Proliferation; Disease Models, Animal; Female; Glucocort

2022
The role of selected molecular factors in ovarian cancer metastasis.
    Ginekologia polska, 2022, Volume: 93, Issue:8

    Topics: Ascites; Carcinoma, Ovarian Epithelial; Cell Movement; Female; Gene Expression Regulation, Neoplasti

2022
Extracellular Acidosis Promotes Metastatic Potency via Decrease of the
    Cells, 2020, 04-16, Volume: 9, Issue:4

    Topics: Acidosis; ARNTL Transcription Factors; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Surviv

2020
Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma.
    Journal of pineal research, 2020, Volume: 69, Issue:2

    Topics: ADAMTS1 Protein; Animals; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Humans; Kidney Ne

2020
Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis.
    Cell death & disease, 2020, 08-18, Volume: 11, Issue:8

    Topics: Animals; beta Catenin; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Epithelial Ce

2020
Melatonin impedes prostate cancer metastasis by suppressing MMP-13 expression.
    Journal of cellular physiology, 2021, Volume: 236, Issue:5

    Topics: Animals; Cell Death; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Humans; Male;

2021
Synergistic potential of dual andrographolide and melatonin targeting of metastatic colon cancer cells: Using the Chou-Talalay combination index method.
    European journal of pharmacology, 2021, Apr-15, Volume: 897

    Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Colonic Neop

2021
FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis.
    Journal of experimental & clinical cancer research : CR, 2021, Mar-10, Volume: 40, Issue:1

    Topics: Animals; Fibroblast Growth Factors; Humans; Melatonin; Mice; Neoplasm Metastasis; Receptor, Fibrobla

2021
Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer.
    Human & experimental toxicology, 2021, Volume: 40, Issue:9

    Topics: Angiogenesis Modulating Agents; Animals; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal;

2021
Melanin pigmentation and melanoma.
    Experimental dermatology, 2017, Volume: 26, Issue:7

    Topics: DNA Damage; Humans; Melanins; Melanocytes; Melanoma; Melatonin; Neoplasm Metastasis; Oxidants; Pigme

2017
Melatonin inhibits osteosarcoma stem cells by suppressing SOX9-mediated signaling.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Separation; Cell Survival; Disease Progression; Epith

2018
Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:3

    Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cadherins

2019
Melatonin effect on the ultrastructure of Ehrlich ascites tumor cells, lifetime and histopathology in Swiss mice.
    Life sciences, 2013, Nov-26, Volume: 93, Issue:23

    Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Ehrlich Tumor; Cell Proliferatio

2013
Molecular markers of angiogenesis and metastasis in lines of oral carcinoma after treatment with melatonin.
    Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:9

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Gene Expression; Humans;

2014
Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression.
    Journal of pineal research, 2016, Volume: 60, Issue:1

    Topics: Amides; Animals; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Melatonin; Mice; Mice, Nude; Ne

2016
Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma.
    Journal of pineal research, 2016, Volume: 60, Issue:2

    Topics: Animals; Cell Survival; Female; Glycolysis; Humans; Leiomyosarcoma; Melatonin; Neoplasm Metastasis;

2016
Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity.
    Journal of pineal research, 2016, Volume: 60, Issue:3

    Topics: Animals; Carcinoma, Renal Cell; DNA, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Express

2016
Melatonin Represses Metastasis in Her2-Postive Human Breast Cancer Cells by Suppressing RSK2 Expression.
    Molecular cancer research : MCR, 2016, Volume: 14, Issue:11

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gene Express

2016
Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma.
    Journal of pineal research, 2016, Volume: 61, Issue:4

    Topics: Carcinoma; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expressi

2016
Melatonin Immunoreactivity in Malignant Small Intestinal Neuroendocrine Tumours.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Gene Expression Regulation, Neoplasti

2016
Comparison of circadian characteristics for cytotoxic lymphocyte subsets in non-small cell lung cancer patients versus controls.
    Clinical and experimental medicine, 2012, Volume: 12, Issue:3

    Topics: Adult; Analysis of Variance; B-Lymphocyte Subsets; Body Mass Index; Carcinoma, Non-Small-Cell Lung;

2012
DEMONSTRATION OF HYDROXYINDOLE-O-METHYL TRANSFERASE, MELATONIN, AND SEROTONIN IN A METASTATIC PARENCHYMATOUS PINEALOMA.
    Nature, 1964, Dec-26, Volume: 204

    Topics: Carbon Isotopes; Chromatography; Histocytochemistry; Indoles; Melatonin; Neoplasm Metastasis; Pineal

1964
Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma.
    European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:2

    Topics: Adult; Aged; Biopterins; Carcinoma, Hepatocellular; Eosinophils; Female; Humans; Injections, Subcuta

1994
Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells.
    Cancer research, 1998, Oct-01, Volume: 58, Issue:19

    Topics: Adipose Tissue; Animals; Antineoplastic Agents; Basement Membrane; Breast Neoplasms; Cadherins; Cell

1998
Studies of the interactions between melatonin and 2 Hz, 0.3 mT PEMF on the proliferation and invasion of human breast cancer cells.
    Bioelectromagnetics, 2001, Volume: 22, Issue:3

    Topics: Breast Neoplasms; Cell Division; Electromagnetic Fields; Female; Humans; Melatonin; Neoplasm Invasiv

2001
Direct antiproliferative effects of melatonin on two metastatic cell sublines of mouse melanoma (B16BL6 and PG19).
    Melanoma research, 2001, Volume: 11, Issue:2

    Topics: Animals; Coloring Agents; Dose-Response Relationship, Drug; Humans; Melanoma, Experimental; Melatoni

2001
[Dynamics of changes in enterochromaffin cells during tumor growth].
    Voprosy onkologii, 1976, Volume: 22, Issue:1

    Topics: Chromaffin System; Enterochromaffin Cells; Gastrointestinal Neoplasms; Humans; Hyperplasia; Leukemia

1976
Plasma melatonin in patients with breast cancer.
    Oncology, 1990, Volume: 47, Issue:5

    Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Melatonin; Menopause; Middle Aged; Neoplasm Met

1990
A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates.
    Tumori, 1990, Feb-28, Volume: 76, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance; Female; Fluorouracil; Fol

1990
Relation between lymphocyte subpopulations and pineal function in patients with early or metastatic cancer.
    Annals of the New York Academy of Sciences, 1988, Volume: 521

    Topics: Adult; Aged; Female; Humans; Immunity, Cellular; Lymphocytes; Male; Melatonin; Middle Aged; Neoplasm

1988
The clinical significance of melatonin serum determination in oncological patients and its correlations with GH and PRL blood levels.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Growth Hormone; Humans; Ma

1987