melatonin has been researched along with Metabolic Diseases in 25 studies
Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This experiment focused on the role of melatonin in regulating the gut microbiota and explores its mechanism on dextran sulphate sodium- (DSS-) induced neuroinflammation and liver injury." | 7.96 | Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats. ( Chao, LM; Guo, A; Guo, SN; Li, Y; Liu, C; Lv, WJ; Qu, Q; Tang, XG; Wei, GW; Xiong, Y; Yin, YL; Yu, LZ; Zhou, JH, 2020) |
| "Melatonin can reduce damage to male rodents' gonadal tissue and improve sperm count, motility, and morphology in metabolic diseases." | 5.41 | Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models. ( Ala, M; Azarpira, N; Dehdari Ebrahimi, N; Ebrahimi, F; Pakbaz, S; Sadeghi, A, 2023) |
| "Our results show that melatonin is effective in attenuating SGAs' adverse metabolic effects, particularly in bipolar disorder." | 5.19 | Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial. ( Alvarez-Icaza González, D; Becerra-Palars, C; Berlanga, C; Buijs, RM; Fresán-Orellana, A; Heinze, G; Moreno, J; Ontiveros Uribe, MP; Romo-Nava, F; Saracco Alvarez, R, 2014) |
| " This experiment focused on the role of melatonin in regulating the gut microbiota and explores its mechanism on dextran sulphate sodium- (DSS-) induced neuroinflammation and liver injury." | 3.96 | Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats. ( Chao, LM; Guo, A; Guo, SN; Li, Y; Liu, C; Lv, WJ; Qu, Q; Tang, XG; Wei, GW; Xiong, Y; Yin, YL; Yu, LZ; Zhou, JH, 2020) |
| "Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring." | 3.91 | Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring. ( Amaral, F; Cipolla-Neto, J; Lowden, A; Moreno, CRC; Nehme, PA; Skene, DJ, 2019) |
| "Melatonin is a pineal hormone that has acquired several unique modes of regulating the physiological effects in mammals due to its characteristic phylogenetic history." | 2.61 | New insights into the function of melatonin and its role in metabolic disturbances. ( Amaral, FGD; Andrade-Silva, J; Cipolla-Neto, J; Kuwabara, WMT, 2019) |
| "Both obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society." | 2.55 | Artificial light-at-night - a novel lifestyle risk factor for metabolic disorder and cancer morbidity. ( Haim, A; Zubidat, AE, 2017) |
| "Melatonin is a highly pleiotropic regulator molecule, which influences numerous functions in almost every organ and, thus, up- or down-regulates many genes, frequently in a circadian manner." | 2.50 | Melatonin, noncoding RNAs, messenger RNA stability and epigenetics--evidence, hints, gaps and perspectives. ( Hardeland, R, 2014) |
| "Melatonin is a multifunctional indolamine that has marked beneficial effect on peroxinitrite-induced cellular toxicity confirmed in numerous experimental and clinical studies." | 2.47 | [Oxidative stress and possibilities of its correction by melatonin]. ( , 2011) |
| "Early-life sleep deprivation (ESD) is a serious condition with severe metabolic sequelae." | 1.42 | Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency. ( Chang, HM; Chen, LY; Liao, WC; Mai, FD; Tiong, C; Tsai, CH; Yang, SF; Youn, SC, 2015) |
| "Melatonin treatment reduced hyperglycemia, polydipsia, and polyphagia as well as improved insulin resistance as demonstrated by constant glucose disappearance rate and homeostasis model of assessment-insulin resistance." | 1.38 | Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment. ( Andreotti, S; Campaña, AB; Carpinelli, AR; Cipolla-Neto, J; de Oliveira, AC; de Proença, AR; de Souza, AH; Farias, Tda S; Lima, FB; Sertié, RA; Torres-Leal, FL, 2012) |
| "Melatonin treatment (10 mg/kg, 18 days) did not influence the level of hyperglycemia or glycated hemoglobin and it had little effect on the activities of antioxidative enzymes." | 1.34 | Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats. ( Bryszewska, M; Kubyshin, VL; Lapshina, EA; Maksimchik, YZ; Reiter, RJ; Sudnikovich, EJ; Zabrodskaya, SV; Zavodnik, IB, 2007) |
| "Co-treatment with melatonin inhibited the elevation of lipid peroxidation and significantly increased GSH-Px activity in the brain regions studied." | 1.33 | Melatonin prevents oxidative stress and inhibits reactive gliosis induced by hyperhomocysteinemia in rats. ( Baydas, G; Koz, ST; Ozer, M; Tuzcu, M; Yasar, A, 2006) |
| "Melatonin treatment counteracted these alterations in young and aged septic rats." | 1.33 | Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 16 (64.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lim, S | 1 |
| Park, S | 1 |
| Koyanagi, A | 1 |
| Yang, JW | 1 |
| Jacob, L | 1 |
| Yon, DK | 1 |
| Lee, SW | 1 |
| Kim, MS | 1 |
| Il Shin, J | 1 |
| Smith, L | 1 |
| Dehdari Ebrahimi, N | 1 |
| Sadeghi, A | 1 |
| Ala, M | 1 |
| Ebrahimi, F | 1 |
| Pakbaz, S | 1 |
| Azarpira, N | 1 |
| Nehme, PA | 1 |
| Amaral, F | 1 |
| Lowden, A | 1 |
| Skene, DJ | 1 |
| Cipolla-Neto, J | 3 |
| Moreno, CRC | 1 |
| Imenshahidi, M | 1 |
| Karimi, G | 1 |
| Hosseinzadeh, H | 1 |
| Lv, WJ | 1 |
| Liu, C | 1 |
| Yu, LZ | 1 |
| Zhou, JH | 1 |
| Li, Y | 1 |
| Xiong, Y | 1 |
| Guo, A | 1 |
| Chao, LM | 1 |
| Qu, Q | 1 |
| Wei, GW | 1 |
| Tang, XG | 1 |
| Yin, YL | 1 |
| Guo, SN | 1 |
| Olcese, J | 1 |
| Jockers, R | 1 |
| Zubidat, AE | 1 |
| Haim, A | 1 |
| Kamath, A | 1 |
| Rather, ZA | 1 |
| Amaral, FGD | 1 |
| Andrade-Silva, J | 1 |
| Kuwabara, WMT | 1 |
| Chen, LY | 1 |
| Tiong, C | 1 |
| Tsai, CH | 1 |
| Liao, WC | 1 |
| Yang, SF | 1 |
| Youn, SC | 1 |
| Mai, FD | 1 |
| Chang, HM | 1 |
| Modabbernia, A | 1 |
| Heidari, P | 1 |
| Soleimani, R | 1 |
| Sobhani, A | 1 |
| Roshan, ZA | 1 |
| Taslimi, S | 1 |
| Ashrafi, M | 1 |
| Modabbernia, MJ | 1 |
| Romo-Nava, F | 1 |
| Alvarez-Icaza González, D | 1 |
| Fresán-Orellana, A | 1 |
| Saracco Alvarez, R | 1 |
| Becerra-Palars, C | 1 |
| Moreno, J | 1 |
| Ontiveros Uribe, MP | 1 |
| Berlanga, C | 1 |
| Heinze, G | 1 |
| Buijs, RM | 1 |
| Hardeland, R | 1 |
| Challet, E | 1 |
| Jiang, W | 1 |
| Tian, X | 1 |
| Wang, Y | 1 |
| Sun, Z | 1 |
| Dong, P | 1 |
| Wang, C | 1 |
| Huo, X | 1 |
| Zhang, B | 1 |
| Huang, S | 1 |
| Deng, S | 1 |
| Wang, X | 1 |
| Ma, X | 1 |
| Dzherieva, IS | 1 |
| Volkova, NI | 1 |
| Escames, G | 2 |
| López, LC | 2 |
| García, JA | 1 |
| García-Corzo, L | 1 |
| Ortiz, F | 2 |
| Acuña-Castroviejo, D | 2 |
| de Oliveira, AC | 1 |
| Andreotti, S | 1 |
| Farias, Tda S | 1 |
| Torres-Leal, FL | 1 |
| de Proença, AR | 1 |
| Campaña, AB | 1 |
| de Souza, AH | 1 |
| Sertié, RA | 1 |
| Carpinelli, AR | 1 |
| Lima, FB | 1 |
| Vogel, M | 1 |
| Braungardt, T | 1 |
| Meyer, W | 1 |
| Schneider, W | 1 |
| Corbalán-Tutau, D | 1 |
| Madrid, JA | 1 |
| Nicolás, F | 1 |
| Garaulet, M | 1 |
| Baydas, G | 1 |
| Ozer, M | 1 |
| Yasar, A | 1 |
| Koz, ST | 1 |
| Tuzcu, M | 1 |
| Ros, E | 1 |
| Sudnikovich, EJ | 1 |
| Maksimchik, YZ | 1 |
| Zabrodskaya, SV | 1 |
| Kubyshin, VL | 1 |
| Lapshina, EA | 1 |
| Bryszewska, M | 1 |
| Reiter, RJ | 1 |
| Zavodnik, IB | 1 |
| Zappella, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of Melatonin Adjunct to Olanzapine for Prevention of Olanzapine-associated Metabolic Side Effects.[NCT01593774] | Phase 2 | 36 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Meal Timing, Genetics and Weight Loss in a Mediterranean Population[NCT02829619] | 5,788 participants (Anticipated) | Observational | 2008-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for melatonin and Metabolic Diseases
| Article | Year |
|---|---|
Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials.
Topics: Humans; Melatonin; Mental Disorders; Metabolic Diseases; Pain, Postoperative; Randomized Controlled | 2022 |
Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models.
Topics: Animals; Body Weight; Diabetes Mellitus; Hyperthyroidism; Infertility, Male; Male; Melatonin; Metabo | 2023 |
Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Free Radical Scavengers; Heart Disease Risk Factors; | 2020 |
Artificial light-at-night - a novel lifestyle risk factor for metabolic disorder and cancer morbidity.
Topics: Circadian Clocks; DNA Methylation; Gene Expression Regulation; Humans; Life Style; Light; Melatonin; | 2017 |
Melatonin for Atypical Antipsychotic-Induced Metabolic Adverse Effects: A Meta-Analysis of Randomized Controlled Trials.
Topics: Antipsychotic Agents; Blood Pressure; Humans; Melatonin; Mental Disorders; Metabolic Diseases; Rando | 2018 |
New insights into the function of melatonin and its role in metabolic disturbances.
Topics: Animals; Circadian Rhythm; Energy Metabolism; Humans; Melatonin; Metabolic Diseases | 2019 |
Melatonin, noncoding RNAs, messenger RNA stability and epigenetics--evidence, hints, gaps and perspectives.
Topics: Animals; Circadian Clocks; DNA Methylation; Epigenesis, Genetic; Humans; Melatonin; Mental Disorders | 2014 |
Keeping circadian time with hormones.
Topics: Chronobiology Disorders; Circadian Clocks; Ghrelin; Glucocorticoids; Hormones; Humans; Insulin; Lept | 2015 |
[Arterial hypertension and metabolic disorders].
Topics: Circadian Rhythm; CLOCK Proteins; Depression; Humans; Hypertension; Hypertrophy, Left Ventricular; K | 2010 |
Mitochondrial DNA and inflammatory diseases.
Topics: Autoimmune Diseases; Carrier Proteins; DNA, Mitochondrial; Humans; Immunity, Innate; Inflammation; M | 2012 |
[Oxidative stress and possibilities of its correction by melatonin].
Topics: Antioxidants; Humans; Melatonin; Metabolic Diseases; Oxidative Stress | 2011 |
The effects of shift work on physical and mental health.
Topics: Adaptation, Physiological; Adaptation, Psychological; Cardiovascular Diseases; Circadian Rhythm; Cog | 2012 |
2 trials available for melatonin and Metabolic Diseases
| Article | Year |
|---|---|
Melatonin for prevention of metabolic side-effects of olanzapine in patients with first-episode schizophrenia: randomized double-blind placebo-controlled study.
Topics: Adolescent; Adult; Aged; Antioxidants; Antipsychotic Agents; Benzodiazepines; Double-Blind Method; F | 2014 |
Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial.
Topics: Adult; Analysis of Variance; Anthropometry; Antioxidants; Bipolar Disorder; Double-Blind Method; Fem | 2014 |
11 other studies available for melatonin and Metabolic Diseases
| Article | Year |
|---|---|
Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring.
Topics: Circadian Rhythm; Energy Metabolism; Female; Fetus; Glucose Intolerance; Humans; Insulin Resistance; | 2019 |
Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats.
Topics: Animals; Central Nervous System Depressants; Dextran Sulfate; Inflammation; Male; Melatonin; Metabol | 2020 |
Editorial: Melatonin in Health and Disease.
Topics: Animals; Circadian Rhythm; Health Status; Humans; Melatonin; Metabolic Diseases; Pineal Gland | 2020 |
Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency.
Topics: Age Factors; Animals; Calcium Signaling; Cyclic AMP Response Element-Binding Protein; Male; Melatoni | 2015 |
The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes.
Topics: Anthraquinones; Arylsulfotransferase; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P | 2016 |
Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Ins | 2012 |
Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components.
Topics: Adult; Anthropometry; Circadian Rhythm; Female; Humans; Hydrocortisone; Linear Models; Melatonin; Me | 2014 |
Melatonin prevents oxidative stress and inhibits reactive gliosis induced by hyperhomocysteinemia in rats.
Topics: Administration, Oral; Animals; Antioxidants; Brain Chemistry; Cerebral Cortex; Gliosis; Hippocampus; | 2006 |
Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment.
Topics: Aging; Animals; Antioxidants; Endotoxemia; Enzyme Induction; Injections; Kidney Diseases; Lipid Pero | 2006 |
Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glucosephosphate Dehydrogenas | 2007 |
Autism and hypomelanosis of Ito in twins.
Topics: Adolescent; Autistic Disorder; Brain; Corpus Callosum; Humans; Karyotyping; Magnetic Resonance Imagi | 1993 |