Page last updated: 2024-10-19

melatonin and Mental Disorders

melatonin has been researched along with Mental Disorders in 80 studies

Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.

Research Excerpts

ExcerptRelevanceReference
"We studied the usefulness of melatonin for sleep disorders and emotional/behavior disturbances of patients with developmental disorders."9.09[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. ( Ishizaki, A; Sugama, M; Takeuchi, N, 1999)
"There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy."8.91The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. ( Fusco, AD; Moyanova, S; Ngomba, RT; Tchekalarova, J, 2015)
"Melatonin is an ancient molecule that is evident in high concentrations in various tissues throughout the body."6.72Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders. ( Brown, GM; Gonçalves, VF; Kennedy, JL; Melhuish Beaupre, LM, 2021)
"Treatment with melatonin is useful in a diverse range of medical conditions, including bipolar disorder, Alzheimer's disease, depression and fibromyalgia."6.50Local melatonin regulates inflammation resolution: a common factor in neurodegenerative, psychiatric and systemic inflammatory disorders. ( Anderson, G; Maes, M, 2014)
"Our results show that melatonin is effective in attenuating SGAs' adverse metabolic effects, particularly in bipolar disorder."5.19Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial. ( Alvarez-Icaza González, D; Becerra-Palars, C; Berlanga, C; Buijs, RM; Fresán-Orellana, A; Heinze, G; Moreno, J; Ontiveros Uribe, MP; Romo-Nava, F; Saracco Alvarez, R, 2014)
"We studied the usefulness of melatonin for sleep disorders and emotional/behavior disturbances of patients with developmental disorders."5.09[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. ( Ishizaki, A; Sugama, M; Takeuchi, N, 1999)
"There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy."4.91The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. ( Fusco, AD; Moyanova, S; Ngomba, RT; Tchekalarova, J, 2015)
"The aim of this review was to summarize the potential use of melatonin in the treatment of mental disorders, specifically bipolar disorders, depression, and schizophrenia."4.85Melatonin as a potential therapeutic agent in psychiatric illness. ( Maldonado, MD; Pérez-San-Gregorio, MA; Reiter, RJ, 2009)
"The prevalence of type 2 diabetes is increased in individuals with mental disorders."2.72Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries. ( Ajjan, RA; Al Azdi, Z; Aslam, F; Churchill, R; Mishu, MP; Philip, S; Siddiqi, N; Stubbs, B; Tirbhowan, N; Uphoff, E; Wright, J, 2021)
"Melatonin is an ancient molecule that is evident in high concentrations in various tissues throughout the body."2.72Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders. ( Brown, GM; Gonçalves, VF; Kennedy, JL; Melhuish Beaupre, LM, 2021)
"Treatment with ritanserin appeared to be ineffective."2.67Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin. ( Den Boer, JA; Westenberg, HG, 1990)
" However, there is still uncertainty concerning dosing regimens and a lack of other data."2.61Pediatric sleep disturbances and treatment with melatonin. ( Argentiero, A; D'Alonzo, R; Di Genova, L; Esposito, S; Fattorusso, A; Laino, D; Mencarelli, A; Mencaroni, E, 2019)
"Melatonin is a molecule with numerous properties applicable to the treatment of neurological diseases."2.55Clinical Uses of Melatonin in Neurological Diseases and Mental and Behavioural Disorders. ( Martinez-Cue, C; Mediavilla, MD; Reiter, RJ; Rueda, N; Sanchez-Barcelo, EJ, 2017)
"Melatoninergic agonists have been shown to reliably entrain circadian rhythms, if chronobiological phase response rules are followed."2.53Melatonin and Synthetic Melatoninergic Agonists in Psychiatric and Age-associated Disorders: Successful and Unsuccessful Approaches. ( Hardeland, R, 2016)
"Sleep disorders and neurodegenerative diseases are commonly encountered in primary care."2.53Importance of Rapid Eye Movement Sleep Behavior Disorder to the Primary Care Physician. ( Howell, MJ; McCarter, SJ, 2016)
"Pediatric insomnia is an extrinsic sleep disorder subdivided into two categories: behavioral insomnia and insomnia related to medical, neurological, and psychiatric diseases."2.50Pediatric insomnia: clinical, diagnosis, and treatment. ( Miano, S; Peraita-Adrados, R, 2014)
"Treatment with melatonin is useful in a diverse range of medical conditions, including bipolar disorder, Alzheimer's disease, depression and fibromyalgia."2.50Local melatonin regulates inflammation resolution: a common factor in neurodegenerative, psychiatric and systemic inflammatory disorders. ( Anderson, G; Maes, M, 2014)
"Melatonin is a highly pleiotropic regulator molecule, which influences numerous functions in almost every organ and, thus, up- or down-regulates many genes, frequently in a circadian manner."2.50Melatonin, noncoding RNAs, messenger RNA stability and epigenetics--evidence, hints, gaps and perspectives. ( Hardeland, R, 2014)
" The recognition of the periodicity of biological processes makes the optimal dosing of certain drugs feasible."2.48[Physiological and pathophysiological role of the circadian clock system]. ( Halmos, T; Suba, I, 2012)
"Melatonin is an endocrine output signal of the clock and provides circadian information as an endogenous synchronizer which stabilizes and reinforces circadian rhythms."2.44Melatonin, consciousness, and traumatic stress. ( Bob, P; Fedor-Freybergh, P, 2008)
"Circadian Rhythm Sleep Disorders (CRSD) are a group of sleep disorders characterized by a de-synchronization between a person's biological clock and the environmental 24-hour schedule."2.41Circadian Rhythm Sleep Disorders (CRSD) in psychiatry--a review. ( Dagan, Y, 2002)
"Treatment with melatonin was associated with suicide and suicide attempt."1.72Associations between treatment with melatonin and suicidal behavior: a nationwide cohort study. ( Erlangsen, A; Hawton, K; Høier, NK; Jennum, P; Madsen, T; Nordentoft, M; Spira, AP, 2022)
"Melatonin is a hormone secreted by the pineal gland at night."1.51The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS). ( Geoffroy, PA; Lopez, R; Micoulaud Franchi, JA; Schroder, CM, 2019)
"Melatonin is a drug widely used, particularly for electroencephalogram in children."1.43Efficiency of Melatonin as Compared to Pentobarbital for Audiometry Brainstem Response in Children With Associated Disorders. ( Garabedian, EN; Guerlain, J; Loundon, N; Parodi, M; Paul, A; Rouillon, I, 2016)
"Treatment with melatonin led to significant decrease in oxidative injury."1.35Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis. ( Akbas, A; Ozyurt, B; Ozyurt, H; Parlaktas, BS; Tunc, AT, 2008)
"Melatonin synthesis was just becoming apparent at 2100h."1.28Human melatonin response to light at different times of the night. ( Armstrong, SM; Burrows, GD; McIntyre, IM; Norman, TR, 1989)

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199015 (18.75)18.7374
1990's11 (13.75)18.2507
2000's19 (23.75)29.6817
2010's29 (36.25)24.3611
2020's6 (7.50)2.80

Authors

AuthorsStudies
Starr, KE1
Burns, K1
Demler, TL1
Lim, S1
Park, S1
Koyanagi, A1
Yang, JW1
Jacob, L1
Yon, DK1
Lee, SW1
Kim, MS1
Il Shin, J1
Smith, L1
Høier, NK1
Madsen, T1
Spira, AP1
Hawton, K1
Jennum, P1
Nordentoft, M1
Erlangsen, A1
Mishu, MP1
Uphoff, E1
Aslam, F1
Philip, S1
Wright, J1
Tirbhowan, N1
Ajjan, RA1
Al Azdi, Z1
Stubbs, B1
Churchill, R1
Siddiqi, N1
Melhuish Beaupre, LM1
Brown, GM1
Gonçalves, VF1
Kennedy, JL1
Romo-Nava, F2
Buijs, RM2
McElroy, SL1
Tordjman, S1
Chokron, S1
Delorme, R1
Charrier, A1
Bellissant, E1
Jaafari, N1
Fougerou, C1
Sanchez-Barcelo, EJ1
Rueda, N1
Mediavilla, MD1
Martinez-Cue, C1
Reiter, RJ3
Carpentieri, AR1
Peralta Lopez, ME1
Aguilar, J1
Solá, VM1
Kamath, A1
Rather, ZA1
Esposito, S1
Laino, D1
D'Alonzo, R1
Mencarelli, A1
Di Genova, L1
Fattorusso, A1
Argentiero, A1
Mencaroni, E1
Stanford, SC1
Geoffroy, PA1
Micoulaud Franchi, JA1
Lopez, R1
Schroder, CM1
Amos, LB1
Grekowicz, ML1
Kuhn, EM1
Olstad, JD1
Collins, MM1
Norins, NA1
D'Andrea, LA1
Miano, S1
Peraita-Adrados, R1
O'Neill, B1
Gardani, M1
Findlay, G1
Whyte, T1
Cullen, T1
Chakraborty, J1
Nthenge-Ngumbau, DN1
Rajamma, U1
Mohanakumar, KP1
Alvarez-Icaza González, D1
Fresán-Orellana, A1
Saracco Alvarez, R1
Becerra-Palars, C1
Moreno, J1
Ontiveros Uribe, MP1
Berlanga, C1
Heinze, G1
Anderson, G2
Maes, M1
Hardeland, R2
Colin-Gonzalez, AL1
Aguilera, G1
Serratos, IN1
Escribano, BM1
Santamaria, A1
Tunez, I1
Tchekalarova, J1
Moyanova, S1
Fusco, AD1
Ngomba, RT1
Puustjärvi, A1
Raunio, H1
Lecklin, A1
Kumpulainen, K1
Guerlain, J1
Paul, A1
Rouillon, I1
Parodi, M1
Garabedian, EN1
Loundon, N1
McCarter, SJ1
Howell, MJ1
Maldonado, MD2
Pérez-San-Gregorio, MA2
Hocking, B1
Verster, GC1
Feucht, C1
Patel, DR1
López-Muñoz, F1
Molina, JD1
Rubio, G1
Alamo, C1
De Leersnyder, H1
Zisapel, N1
Laudon, M1
Guénolé, F1
Baleyte, JM1
Vogel, M1
Braungardt, T1
Meyer, W1
Schneider, W1
Halmos, T1
Suba, I1
Haridas, S1
Kumar, M1
Manda, K1
Dagan, Y2
Muñoz Barragán, L1
Dawson, KA1
Bertsche, T1
Schulz, M1
Malhotra, S1
Sawhney, G1
Pandhi, P1
Huuhka, K1
Riutta, A1
Haataja, R1
Ylitalo, P1
Leinonen, E1
Touitou, Y2
Altun, A1
Ugur-Altun, B1
Guardiola-Lemaitre, B1
Bhattacharjee, Y1
Barton, R1
Parlaktas, BS1
Ozyurt, B1
Ozyurt, H1
Tunc, AT1
Akbas, A1
Bob, P1
Fedor-Freybergh, P1
Ferrier, IN1
Johnstone, EC1
Crow, TJ1
Arendt, J2
Wetterberg, L2
Aperia, B1
Beck-Friis, J1
Kjellman, BF1
Ljunggren, JG1
Nilsonne, A1
Petterson, U1
Tham, A1
Undén, F1
Preslock, JP1
Karasek, M1
Lewy, AJ2
Sack, RA1
Singer, CL1
Mullen, PE1
Smith, I1
Nir, I1
Sandyk, R2
Awerbuch, GI1
Waldhauser, F1
Ehrhart, B1
Förster, E1
Selmaoui, B1
Zhao, ZY1
San Martin, M1
Bogdan, A1
Penev, PD1
Zee, PC1
Asplund, R1
Ishizaki, A1
Sugama, M1
Takeuchi, N1
Pacchierotti, C1
Iapichino, S1
Bossini, L1
Pieraccini, F1
Castrogiovanni, P1
Smith, JA2
Mee, TJ2
Barnes, JL2
Lerner, AB1
Nordlund, JJ1
Campbell, KM1
Wade, D1
Ross, LW1
Meyer, GG1
Kay, SR1
Den Boer, JA1
Westenberg, HG1
Claustrat, B1
Brun, J1
Chazot, G1
Maurizi, CP1
McIntyre, IM1
Norman, TR1
Burrows, GD1
Armstrong, SM1
Miles, A1
Philbrick, DR1
Sack, RL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Melatonin Dose-effect Relation in Childhood Autism[NCT01780883]Phase 234 participants (Actual)Interventional2013-02-28Completed
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197]Phase 4104 participants (Actual)Interventional2018-08-06Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

47 reviews available for melatonin and Mental Disorders

ArticleYear
Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials.
    Pharmacological research, 2022, Volume: 176

    Topics: Humans; Melatonin; Mental Disorders; Metabolic Diseases; Pain, Postoperative; Randomized Controlled

2022
Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries.
    The Cochrane database of systematic reviews, 2021, 02-16, Volume: 2

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antioxidants; Antipsychotic Agents; Blood Glucose; Bo

2021
Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders.
    Translational psychiatry, 2021, 06-02, Volume: 11, Issue:1

    Topics: Aging; Animals; Antioxidants; Biomarkers; Cognition; Humans; Melatonin; Mental Disorders; Mitochondr

2021
The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics.
    Handbook of clinical neurology, 2021, Volume: 179

    Topics: Antipsychotic Agents; Humans; Melatonin; Mental Disorders; Metabolic Syndrome

2021
Melatonin: Pharmacology, Functions and Therapeutic Benefits.
    Current neuropharmacology, 2017, Volume: 15, Issue:3

    Topics: Animals; Antioxidants; Brain; Circadian Rhythm; Humans; Melatonin; Mental Disorders

2017
Clinical Uses of Melatonin in Neurological Diseases and Mental and Behavioural Disorders.
    Current medicinal chemistry, 2017, Nov-20, Volume: 24, Issue:35

    Topics: Animals; Clinical Trials as Topic; Humans; Melatonin; Mental Disorders; Nervous System Diseases; Oxi

2017
Melatonin and periodontal tissues: Molecular and clinical perspectives.
    Pharmacological research, 2017, Volume: 125, Issue:Pt B

    Topics: Animals; Bone and Bones; Dental Implants; Diabetes Mellitus; Humans; Melatonin; Mental Disorders; Mo

2017
Melatonin for Atypical Antipsychotic-Induced Metabolic Adverse Effects: A Meta-Analysis of Randomized Controlled Trials.
    BioMed research international, 2018, Volume: 2018

    Topics: Antipsychotic Agents; Blood Pressure; Humans; Melatonin; Mental Disorders; Metabolic Diseases; Rando

2018
Pediatric sleep disturbances and treatment with melatonin.
    Journal of translational medicine, 2019, 03-12, Volume: 17, Issue:1

    Topics: Child; Child Behavior; Humans; Melatonin; Mental Disorders; Neurodevelopmental Disorders; Sleep Wake

2019
Pediatric insomnia: clinical, diagnosis, and treatment.
    Revista de neurologia, 2014, Jan-01, Volume: 58, Issue:1

    Topics: Adolescent; Behavior Therapy; Child; Child Behavior Disorders; Chronobiology Disorders; Cognition Di

2014
Local melatonin regulates inflammation resolution: a common factor in neurodegenerative, psychiatric and systemic inflammatory disorders.
    CNS & neurological disorders drug targets, 2014, Volume: 13, Issue:5

    Topics: Humans; Inflammation; Melatonin; Mental Disorders; Neurodegenerative Diseases; Serotonin

2014
Melatonin and Synthetic Melatoninergic Agonists in Psychiatric and Age-associated Disorders: Successful and Unsuccessful Approaches.
    Current pharmaceutical design, 2016, Volume: 22, Issue:8

    Topics: Acetamides; Animals; Humans; Indoles; Melatonin; Memory Disorders; Mental Disorders; Pyrans; Recepto

2016
Melatonin, noncoding RNAs, messenger RNA stability and epigenetics--evidence, hints, gaps and perspectives.
    International journal of molecular sciences, 2014, Oct-10, Volume: 15, Issue:10

    Topics: Animals; Circadian Clocks; DNA Methylation; Epigenesis, Genetic; Humans; Melatonin; Mental Disorders

2014
On the Relationship Between the Light/Dark Cycle, Melatonin and Oxidative Stress.
    Current pharmaceutical design, 2015, Volume: 21, Issue:24

    Topics: Animals; Antioxidants; Biological Clocks; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Neu

2015
The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders.
    Brain research bulletin, 2015, Volume: 119, Issue:Pt A

    Topics: Animals; Comorbidity; Epilepsy; Humans; Melatonin; Mental Disorders

2015
[Drug therapy and the most common drugs for childhood psychiatric disorders].
    Duodecim; laaketieteellinen aikakauskirja, 2016, Volume: 132, Issue:10

    Topics: Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Child; Humans; Melatonin; Ment

2016
Importance of Rapid Eye Movement Sleep Behavior Disorder to the Primary Care Physician.
    Mayo Clinic proceedings, 2016, Volume: 91, Issue:10

    Topics: Central Nervous System Depressants; Clonazepam; Diagnosis, Differential; GABA Modulators; Humans; Me

2016
The role of melatonin in the immuno-neuro-psychology of mental disorders.
    Recent patents on CNS drug discovery, 2009, Volume: 4, Issue:1

    Topics: Animals; Humans; Melatonin; Mental Disorders

2009
Melatonin and its agonists, circadian rhythms and psychiatry.
    African journal of psychiatry, 2009, Volume: 12, Issue:1

    Topics: Adult; Aged; Central Nervous System Depressants; Child; Circadian Rhythm; Humans; Melatonin; Mental

2009
Melatonin as a potential therapeutic agent in psychiatric illness.
    Human psychopharmacology, 2009, Volume: 24, Issue:5

    Topics: Animals; Antioxidants; Humans; Melatonin; Mental Disorders

2009
Herbal medicines in pediatric neuropsychiatry.
    Pediatric clinics of North America, 2011, Volume: 58, Issue:1

    Topics: Adolescent; Child; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Herb-Drug Inte

2011
The effects of shift work on physical and mental health.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:10

    Topics: Adaptation, Physiological; Adaptation, Psychological; Cardiovascular Diseases; Circadian Rhythm; Cog

2012
[Physiological and pathophysiological role of the circadian clock system].
    Orvosi hetilap, 2012, Sep-02, Volume: 153, Issue:35

    Topics: Aging; ARNTL Transcription Factors; Blood Coagulation Disorders; Cardiovascular Diseases; Circadian

2012
Circadian rhythm sleep disorders (CRSD).
    Sleep medicine reviews, 2002, Volume: 6, Issue:1

    Topics: Antipsychotic Agents; Chronotherapy; Humans; Melatonin; Mental Disorders; Phototherapy; Sleep Disord

2002
Temporal organization of the brain: Neurocognitive mechanisms and clinical implications.
    Brain and cognition, 2004, Volume: 54, Issue:1

    Topics: Attention; Brain; Chronobiology Phenomena; Cognition; Consciousness; Humans; Melatonin; Mental Disor

2004
[Melatonin. A clinical-pharmacological assessment].
    Medizinische Monatsschrift fur Pharmazeuten, 2004, Volume: 27, Issue:2

    Topics: Aged; Animals; Antioxidants; Dietary Supplements; Drug Interactions; Humans; Melatonin; Mental Disor

2004
The therapeutic potential of melatonin: a review of the science.
    MedGenMed : Medscape general medicine, 2004, Apr-13, Volume: 6, Issue:2

    Topics: Aging; Animals; Antioxidants; Endocrine System Diseases; Humans; Melatonin; Mental Disorders; Neopla

2004
[Synchronization and desynchronization of the biological clock in man].
    L'Encephale, 2006, Volume: 32, Issue:5 Pt 2

    Topics: Adult; Child; Chronobiology Disorders; Circadian Rhythm; Homeostasis; Humans; Melatonin; Mental Diso

2006
Melatonin: therapeutic and clinical utilization.
    International journal of clinical practice, 2007, Volume: 61, Issue:5

    Topics: Cardiovascular Diseases; Circadian Rhythm; Humans; Immune System; Immune System Diseases; Jet Lag Sy

2007
[Melatoninergic receptor agonists and antagonists: therapeutic perspectives].
    Journal de la Societe de biologie, 2007, Volume: 201, Issue:1

    Topics: Antidepressive Agents; Body Temperature; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Mood

2007
Use of medication in children with psychiatric disorders.
    Community practitioner : the journal of the Community Practitioners' & Health Visitors' Association, 2007, Volume: 80, Issue:11

    Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Child; Child Psychiatry; D

2007
Melatonin, consciousness, and traumatic stress.
    Journal of pineal research, 2008, Volume: 44, Issue:4

    Topics: Animals; Cerebral Cortex; Circadian Rhythm; Consciousness; Gene Expression Regulation; Humans; Long-

2008
The pineal gland: basic implications and clinical correlations.
    Endocrine reviews, 1984,Spring, Volume: 5, Issue:2

    Topics: Adrenal Glands; Animals; Arginine Vasopressin; Brain Neoplasms; Cricetinae; Female; Gonads; Humans;

1984
[Melatonin in humans].
    Endokrynologia Polska, 1984, Volume: 35, Issue:6

    Topics: Adolescent; Adult; Age Factors; Child; Circadian Rhythm; Endocrine System Diseases; Female; Humans;

1984
The endocrinology of the human pineal.
    British journal of hospital medicine, 1981, Volume: 25, Issue:3

    Topics: Acetylserotonin O-Methyltransferase; Animals; Biological Evolution; Child; Circadian Rhythm; Female;

1981
Biorhythms and the biological clock involvement of melatonin and the pineal gland in life and disease.
    Biomedical and environmental sciences : BES, 1995, Volume: 8, Issue:2

    Topics: Adrenal Glands; Animals; Circadian Rhythm; Female; Humans; Immune System; Melatonin; Mental Disorder

1995
Clinical aspects of the melatonin action: impact of development, aging, and puberty, involvement of melatonin in psychiatric disease and importance of neuroimmunoendocrine interactions.
    Experientia, 1993, Aug-15, Volume: 49, Issue:8

    Topics: Aging; Circadian Rhythm; Growth; Humans; Immunity; Melatonin; Mental Disorders; Puberty

1993
[Melatonin and biological rhythms: various aspects in human physiopathology].
    Annales pharmaceutiques francaises, 1996, Volume: 54, Issue:6

    Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Neoplasms; Pineal Gland

1996
Melatonin: a clinical perspective.
    Annals of neurology, 1997, Volume: 42, Issue:4

    Topics: Humans; Melatonin; Mental Disorders; Neuroimmunomodulation; Pineal Gland

1997
Sleep disorders in the elderly.
    Drugs & aging, 1999, Volume: 14, Issue:2

    Topics: Aged; Antidepressive Agents; Benzodiazepines; Comorbidity; Humans; Life Expectancy; Melatonin; Menta

1999
Melatonin in psychiatric disorders: a review on the melatonin involvement in psychiatry.
    Frontiers in neuroendocrinology, 2001, Volume: 22, Issue:1

    Topics: Circadian Rhythm; Humans; Melatonin; Mental Disorders

2001
Circadian Rhythm Sleep Disorders (CRSD) in psychiatry--a review.
    The Israel journal of psychiatry and related sciences, 2002, Volume: 39, Issue:1

    Topics: Antipsychotic Agents; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Phototherapy; Selective

2002
Melatonin in humans physiological and clinical studies.
    Journal of neural transmission. Supplementum, 1978, Issue:13

    Topics: Adolescent; Adult; Aged; Child; Circadian Rhythm; Endocrine System Diseases; Female; Humans; Hydroco

1978
Melatonin in humans, neuroendocrinological and pharmacological aspects.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1990, Volume: 17, Issue:7

    Topics: Animals; Circadian Rhythm; Headache; Humans; Light; Melatonin; Mental Disorders; Pineal Gland

1990
Melatonin: a new probe in psychiatric investigation?
    The British journal of psychiatry : the journal of mental science, 1989, Volume: 155

    Topics: Animals; Bipolar Disorder; Circadian Rhythm; Humans; Light; Melatonin; Mental Disorders; Pineal Glan

1989
Melatonin and psychiatry.
    Biological psychiatry, 1988, Feb-15, Volume: 23, Issue:4

    Topics: Animals; Antidepressive Agents; Brain; Chronobiology Phenomena; Depressive Disorder; Humans; Melaton

1988
Light therapy and psychiatry.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 183, Issue:1

    Topics: Atenolol; Circadian Rhythm; Depression; Depressive Disorder; Humans; Light; Melatonin; Mental Disord

1986

Trials

5 trials available for melatonin and Mental Disorders

ArticleYear
Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial.
    Bipolar disorders, 2014, Volume: 16, Issue:4

    Topics: Adult; Analysis of Variance; Anthropometry; Antioxidants; Bipolar Disorder; Double-Blind Method; Fem

2014
Prolonged-release melatonin for children with neurodevelopmental disorders.
    Pediatric neurology, 2011, Volume: 45, Issue:1

    Topics: Adolescent; Antioxidants; Child; Child, Preschool; Developmental Disabilities; Drug Delivery Systems

2011
The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study.
    Methods and findings in experimental and clinical pharmacology, 2006, Volume: 28, Issue:7

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Ag

2006
[Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders].
    No to hattatsu = Brain and development, 1999, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Affective Symptoms; Child; Child, Preschool; Circadian Rhythm; Developmental Disa

1999
Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin.
    Psychopharmacology, 1990, Volume: 102, Issue:1

    Topics: Adult; beta-Endorphin; Blood Platelets; Double-Blind Method; Fear; Female; Fluvoxamine; Humans; Hydr

1990

Other Studies

28 other studies available for melatonin and Mental Disorders

ArticleYear
Pharmacological and philosophical considerations for the around-the-clock use of scheduled melatonin to promote sedation and reduce aggression in individuals with serious mental illness: a case report.
    International clinical psychopharmacology, 2021, 11-01, Volume: 36, Issue:6

    Topics: Aggression; Drug Administration Schedule; Duration of Therapy; Humans; Melatonin; Mental Disorders;

2021
Associations between treatment with melatonin and suicidal behavior: a nationwide cohort study.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022, 10-01, Volume: 18, Issue:10

    Topics: Cohort Studies; Humans; Melatonin; Mental Disorders; Risk Factors; Suicidal Ideation; Suicide, Attem

2022
Recent developments in research of melatonin and its potential therapeutic applications.
    British journal of pharmacology, 2018, Volume: 175, Issue:16

    Topics: Animals; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Neoplasms; Nervous System Diseases;

2018
The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS).
    L'Encephale, 2019, Volume: 45, Issue:5

    Topics: Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Utilization; France; Guideline Adher

2019
Treatment of pediatric restless legs syndrome.
    Clinical pediatrics, 2014, Volume: 53, Issue:4

    Topics: Adolescent; Amines; Analgesics; Anticonvulsants; Antioxidants; Benzothiazoles; Child; Child, Prescho

2014
Challenging behaviour and sleep cycle disorder following brain injury: a preliminary response to agomelatine treatment.
    Brain injury, 2014, Volume: 28, Issue:3

    Topics: Acetamides; Brain Injuries; Cognition Disorders; Humans; Hypnotics and Sedatives; Male; Melatonin; M

2014
Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease.
    Behavioural brain research, 2014, May-01, Volume: 264

    Topics: Animals; Convulsants; Dendritic Spines; Disease Models, Animal; Dose-Response Relationship, Drug; Dr

2014
Editorial: The Kynurenine and Melatonergic Pathways in Psychiatric and CNS Disorders.
    Current pharmaceutical design, 2016, Volume: 22, Issue:8

    Topics: Central Nervous System Diseases; Humans; Kynurenine; Melatonin; Mental Disorders; Signal Transductio

2016
Efficiency of Melatonin as Compared to Pentobarbital for Audiometry Brainstem Response in Children With Associated Disorders.
    American journal of audiology, 2016, Sep-01, Volume: 25, Issue:3

    Topics: Adolescent; Audiometry, Evoked Response; Central Nervous System Depressants; Child; Child, Preschool

2016
Maternal cell phone use and behavioral problems in children.
    Epidemiology (Cambridge, Mass.), 2009, Volume: 20, Issue:2

    Topics: Cell Phone; Child Behavior; Child, Preschool; Female; Fetal Development; Humans; Melatonin; Mental D

2009
An historical view of the pineal gland and mental disorders.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2011, Volume: 18, Issue:8

    Topics: History, 17th Century; History, 18th Century; History, 19th Century; History, 20th Century; Humans;

2011
Natural supplements for mental health. Some complementary and alternative therapies may be worth trying.
    The Harvard mental health letter, 2011, Volume: 28, Issue:4

    Topics: Complementary Therapies; Dietary Supplements; Fatty Acids, Omega-3; Folic Acid; Ginkgo biloba; Human

2011
Effects of melatonin should be studied separately in each neurodevelopmental disorder and with specific sleep diagnoses.
    Pediatric neurology, 2012, Volume: 46, Issue:1

    Topics: Antioxidants; Developmental Disabilities; Female; Humans; Male; Melatonin; Mental Disorders; Sleep W

2012
Chronic melatonin administration mitigates behavioral dysfunction induced by γ-irradiation.
    Hormones and behavior, 2012, Volume: 62, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Depressive Disorder; Drug Administration Schedule; G

2012
[Biological potentiality of melatonin].
    Anales de la Real Academia Nacional de Medicina, 2002, Volume: 119, Issue:3

    Topics: Antioxidants; Apoptosis; Brain; Calcification, Physiologic; Cell Division; Humans; Melatonin; Mental

2002
Psychiatric research. Is internal timing key to mental health?
    Science (New York, N.Y.), 2007, Sep-14, Volume: 317, Issue:5844

    Topics: Animals; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Clinical Trials as Topic; Hum

2007
Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis.
    Asian journal of andrology, 2008, Volume: 10, Issue:2

    Topics: Animals; Antioxidants; Disease Models, Animal; Dizocilpine Maleate; Male; Malondialdehyde; Melatonin

2008
Melatonin/cortisol ratio in psychiatric illness.
    Lancet (London, England), 1982, May-08, Volume: 1, Issue:8280

    Topics: Humans; Hydrocortisone; Male; Melatonin; Mental Disorders; Middle Aged; Schizophrenia

1982
Melatonin and cortisol levels in psychiatric illness.
    Lancet (London, England), 1982, Jul-10, Volume: 2, Issue:8289

    Topics: Depression; Diagnosis, Differential; Humans; Hydrocortisone; Melatonin; Mental Disorders; Schizophre

1982
Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: the clock-gate model and the phase response curve.
    Psychopharmacology bulletin, 1984,Summer, Volume: 20, Issue:3

    Topics: Circadian Rhythm; Humans; Light; Melatonin; Mental Disorders; Models, Psychological

1984
Multiple sclerosis: the role of the pineal gland in its timing of onset and risk of psychiatric illness.
    The International journal of neuroscience, 1993, Volume: 72, Issue:1-2

    Topics: Adolescent; Adult; Age of Onset; Aged; Female; Humans; Male; Melanins; Melatonin; Mental Disorders;

1993
Elevated melatonin serum concentrations in psychiatric patients treated with chlorpromazine [proceedings].
    The Journal of pharmacy and pharmacology, 1977, Volume: 29 Suppl

    Topics: Adolescent; Adult; Chlorpromazine; Humans; Male; Melatonin; Mental Disorders; Middle Aged; Stimulati

1977
The effect of neuroleptic drugs on serum and cerebrospinal fluid melatonin concentrations in psychiatric subjects.
    The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Antipsychotic Agents; Chlorpromazine; Female; Flupenthixol; Fl

1979
Melatonin: clinical pharmacology.
    Journal of neural transmission. Supplementum, 1978, Issue:13

    Topics: Brain; Brain Diseases; Chemical Phenomena; Chemistry; Humans; Liver; Melatonin; Mental Disorders; Sl

1978
Pigmentation and musculoskeletal abnormalities in an aged state hospital population.
    Journal of the American Geriatrics Society, 1977, Volume: 25, Issue:9

    Topics: Adult; Aged; Bone Diseases; Dihydroxyphenylalanine; Female; Humans; Male; Melanins; Melatonin; Menta

1977
Paraventricular nucleus-pineal interaction: relevance to tardive dyskinesia.
    The International journal of neuroscience, 1992, Volume: 62, Issue:3-4

    Topics: Animals; Antipsychotic Agents; Brain; Brain Diseases; Dyskinesia, Drug-Induced; Female; Humans; Male

1992
The therapeutic potential for tryptophan and melatonin: possible roles in depression, sleep, Alzheimer's disease and abnormal aging.
    Medical hypotheses, 1990, Volume: 31, Issue:3

    Topics: Aging; Animals; Bipolar Disorder; Dementia; Depressive Disorder; Humans; Melatonin; Mental Disorders

1990
Human melatonin response to light at different times of the night.
    Psychoneuroendocrinology, 1989, Volume: 14, Issue:3

    Topics: Adult; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Mental Disorders

1989