melatonin has been researched along with Melanoma in 60 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " One hundred patients recently diagnosed with non-metastatic uveal melanoma will be randomized to either treatment with adjuvant melatonin 20 mg (4 tablets of 5 mg) at 10 pm for 5 years, or to standard follow-up (control group)." | 9.69 | Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study. ( Hagström, A; Kal Omar, R; Stålhammar, G, 2023) |
| "Several experimental studies have shown that melatonin has an oncostatic action, either by stimulating host antitumor immune defenses or by directly inhibiting the growth of some cancer histotypes, including melanoma." | 9.08 | Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. ( Barni, S; Brivio, F; Brivio, O; Crippa, D; Lissoni, P; Meregalli, S; Tancini, G, 1996) |
| " In particular, the association with the pineal neurohormone melatonin (MLT) has been shown to cause tumour regressions in neoplasms that are generally non-responsive to IL-2 alone." | 9.07 | A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Brivio, F; Lissoni, P; Rescaldani, R; Ricci, G; Rovelli, F; Tancini, G; Tisi, E, 1994) |
| "The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma." | 9.07 | Serum melatonin levels in melanoma patients after repeated oral administration. ( Balmer, C; Boose, D; Johnson, A; Kane, MA; Mathai, G; Nash, AE; Robinson, WA; Yohn, JJ, 1994) |
| "Melatonin did not increase the efficacy of systemic chemotherapy in melanoma." | 8.02 | Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma. ( Anisimov, VN; Baldueva, IA; Berstein, LM; Latipova, DK; Novik, AV; Protsenko, SA; Semenova, AI; Semiglazova, TY; Tkachenko, EV; Zhuk, IN, 2021) |
| "Collectively, our results demonstrate melatonin synergizes the antitumor effect of vemurafenib in human melanoma by inhibiting cell proliferation and cancer-stem cell traits via targeting NF-κB/iNOS/hTERT signaling pathway, and suggest the potential of melatonin in antagonizing the toxicity of vemurafenib and augmenting its sensitivities in melanoma treatment." | 7.91 | Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits. ( Chen, M; Deng, W; Diao, C; Fan, W; Guo, P; Guo, W; Hao, J; Hu, S; Jiang, K; Li, L; Li, Y; Long, Q; Qin, G; Qin, L; Ren, Y; Tang, R; Tian, C; Wang, J; Yang, Q; Yu, W; Zhang, C; Zhang, X; Zhou, P; Zhu, T; Zou, L, 2019) |
| "Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo." | 7.73 | Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines. ( Fischer, TW; Slominski, A; Slominski, RM; Sweatman, TW; Wortsman, J; Zbytek, B; Zmijewski, MA, 2006) |
| "Patients with choroidal melanomas had higher levels of serum melatonin compared to individuals without tumours." | 7.72 | Serum melatonin levels following enucleation and transpupillary thermotherapy in patients with choroidal melanoma. ( Bilgiç, S; Gedik, S; Kiratli, H; Us, D, 2003) |
| "The effects of melatonin, N-acetylserotonin and serotonin on the growth and tyrosinase activity of SK-Mel 23 and SK-Mel 28 human melanoma cell lines were investigated." | 7.72 | Melatonin biological activity and binding sites in human melanoma cells. ( Castrucci, AM; Souza, AV; Visconti, MA, 2003) |
| "We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase." | 7.71 | Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. ( Pisarchik, A; Semak, I; Slominski, A; Sweatman, T; Szczesniewski, A; Wortsman, J, 2002) |
| "Previous work has demonstrated that melatonin inhibits growth of cultured human uveal melanoma cells." | 7.70 | Melatonin receptors in human uveal melanocytes and melanoma cells. ( Hu, DN; Roberts, JE; Wiechmann, AF, 2000) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 7.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "The effects of melatonin on the growth of human uveal melanoma cells were studied in vitro." | 7.69 | Melatonin inhibits growth of cultured human uveal melanoma cells. ( Hu, DN; Roberts, JE, 1997) |
| "In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line." | 7.68 | Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin. ( Crocker, C; Niles, LP; Ying, SW, 1993) |
| "Increasing evidence of the immunomodulatory and tumor-depressing effects of melatonin prompted us to study altered concentrations of this multifunctional pineal hormone in the aqueous humor of eyes with melanoma." | 7.68 | [The role of melatonin in growth of malignant choroid melanoma]. ( Gupta, D; Heinze, J; Rohrbach, JM; Thanos, S; Wollmann, H, 1993) |
| "The effect of melatonin on the growth of B16 mice melanoma was examined." | 7.67 | Effect of melatonin on B16 melanoma growth in athymic mice. ( Kudo, H; Narita, T, 1985) |
| "In 19 patients with malignant melanoma of the choroid and 11 controls 20 different metabolic parameters of melanin and melatonin metabolism in urine were examined by high-pressure liquid chromatography (HPLC)." | 7.67 | [HPLC detection of pathologic metabolites of melanin and melatonin metabolism in the urine in malignant melanoma of the choroid]. ( Dieckhues, B, 1986) |
| "Results are given of daily excretion levels of 6-oxymelatonin, thymic serum factor (FTS), and cortisol in the blood of 140 healthy subjects and 90 patients with skin melanoma, ranging from 20 to 49 years of age." | 7.67 | Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma. ( Grinevich, YA; Labunetz, IF, 1986) |
| "Melatonin acts as a free radical scavenger and thus inhibits the initiation of cancer cell growth." | 7.01 | An exclusive review of melatonin effects on mammalian melanocytes and melanoma. ( Ahmad, N; Mubashshir, M; Ovais, M; Sköld, HN, 2023) |
| "Melatonin has been observed to suppress the growth of cancer cells, inhibit metastatic spread, enhance immune system functions, and act as an anti-inflammatory in both in vitro and in vivo models." | 6.82 | The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature. ( Hagström, A; Kal Omar, R; Stålhammar, G; Williams, PA, 2022) |
| "Melatonin is an endogenous hormone and free radical scavenger that possesses the ability to protect the DNA and to exert anti-proliferative effects in melanoma cells." | 5.72 | Anti-genotoxic and anti-mutagenic effects of melatonin supplementation in a mouse model of melanoma. ( Damiani, AP; de Andrade, VM; de Oliveira, CA; Luciano, JA; Martins Longaretti, L; Pereira, M; Rigo, FK; Rohr, P; Steiner, BT; Strapazzon, G; Trevisan, G; Vilela, TC, 2022) |
| " One hundred patients recently diagnosed with non-metastatic uveal melanoma will be randomized to either treatment with adjuvant melatonin 20 mg (4 tablets of 5 mg) at 10 pm for 5 years, or to standard follow-up (control group)." | 5.69 | Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study. ( Hagström, A; Kal Omar, R; Stålhammar, G, 2023) |
| "Melanoma is a leading cause of cancer deaths worldwide." | 5.62 | Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells. ( Bilska, B; Kleszczyński, K; Piotrowska, A; Pyza, E; Reiter, RJ; Schedel, F; Slominski, AT; Stefan, J; Steinbrink, K; Tulic, MK; Zmijewski, M, 2021) |
| "Melatonin and Kiss1 were shown to be nvolved in tumor suppression." | 5.56 | The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. ( Alptekin, D; Kaplan, H; Kasap, H; Lüleyap, U; Pazarci, P; Pelit, A; Singirik, E; Yegani, A; Yilmaz, M, 2020) |
| "Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths." | 5.51 | Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway. ( Chen, M; Deng, W; Fan, W; Hu, Z; Jin, L; Kang, T; Li, J; Li, L; Li, Y; Liu, J; Liu, T; Lu, W; Luo, M; Qiu, H; Tian, C; Yang, L; Zhang, C; Zheng, F; Zheng, Z; Zhu, Q, 2019) |
| "Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties." | 5.36 | Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. ( Cabrera, J; Estévez, F; Loro, J; Negrín, G; Quintana, J; Reiter, RJ, 2010) |
| "Several experimental studies have shown that melatonin has an oncostatic action, either by stimulating host antitumor immune defenses or by directly inhibiting the growth of some cancer histotypes, including melanoma." | 5.08 | Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. ( Barni, S; Brivio, F; Brivio, O; Crippa, D; Lissoni, P; Meregalli, S; Tancini, G, 1996) |
| "The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma." | 5.07 | Serum melatonin levels in melanoma patients after repeated oral administration. ( Balmer, C; Boose, D; Johnson, A; Kane, MA; Mathai, G; Nash, AE; Robinson, WA; Yohn, JJ, 1994) |
| " In particular, the association with the pineal neurohormone melatonin (MLT) has been shown to cause tumour regressions in neoplasms that are generally non-responsive to IL-2 alone." | 5.07 | A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Brivio, F; Lissoni, P; Rescaldani, R; Ricci, G; Rovelli, F; Tancini, G; Tisi, E, 1994) |
| "Melatonin did not increase the efficacy of systemic chemotherapy in melanoma." | 4.02 | Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma. ( Anisimov, VN; Baldueva, IA; Berstein, LM; Latipova, DK; Novik, AV; Protsenko, SA; Semenova, AI; Semiglazova, TY; Tkachenko, EV; Zhuk, IN, 2021) |
| "Collectively, our results demonstrate melatonin synergizes the antitumor effect of vemurafenib in human melanoma by inhibiting cell proliferation and cancer-stem cell traits via targeting NF-κB/iNOS/hTERT signaling pathway, and suggest the potential of melatonin in antagonizing the toxicity of vemurafenib and augmenting its sensitivities in melanoma treatment." | 3.91 | Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits. ( Chen, M; Deng, W; Diao, C; Fan, W; Guo, P; Guo, W; Hao, J; Hu, S; Jiang, K; Li, L; Li, Y; Long, Q; Qin, G; Qin, L; Ren, Y; Tang, R; Tian, C; Wang, J; Yang, Q; Yu, W; Zhang, C; Zhang, X; Zhou, P; Zhu, T; Zou, L, 2019) |
| "Indolic and kynuric pathways of skin melatonin metabolism were monitored by liquid chromatography mass spectrometry in human keratinocytes, melanocytes, dermal fibroblasts, and melanoma cells." | 3.79 | Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. ( Fischer, TW; Janjetovic, Z; Kim, TK; Kleszczynski, K; Li, W; Lin, Z; Reiter, RJ; Slominski, AT; Sweatman, T, 2013) |
| "Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo." | 3.73 | Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines. ( Fischer, TW; Slominski, A; Slominski, RM; Sweatman, TW; Wortsman, J; Zbytek, B; Zmijewski, MA, 2006) |
| "Patients with choroidal melanomas had higher levels of serum melatonin compared to individuals without tumours." | 3.72 | Serum melatonin levels following enucleation and transpupillary thermotherapy in patients with choroidal melanoma. ( Bilgiç, S; Gedik, S; Kiratli, H; Us, D, 2003) |
| "The effects of melatonin, N-acetylserotonin and serotonin on the growth and tyrosinase activity of SK-Mel 23 and SK-Mel 28 human melanoma cell lines were investigated." | 3.72 | Melatonin biological activity and binding sites in human melanoma cells. ( Castrucci, AM; Souza, AV; Visconti, MA, 2003) |
| "We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase." | 3.71 | Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. ( Pisarchik, A; Semak, I; Slominski, A; Sweatman, T; Szczesniewski, A; Wortsman, J, 2002) |
| "The hormone melatonin modulates constitutive protein secretion and inhibits cGMP in melanoma M2R cells via cholera-toxin (CTX) sensitive pathways." | 3.70 | A role for NAD+ and cADP-ribose in melatonin signal transduction. ( Bubis, M; Zisapel, N, 1998) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 3.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "Previous work has demonstrated that melatonin inhibits growth of cultured human uveal melanoma cells." | 3.70 | Melatonin receptors in human uveal melanocytes and melanoma cells. ( Hu, DN; Roberts, JE; Wiechmann, AF, 2000) |
| "The effects of melatonin on the growth of human uveal melanoma cells were studied in vitro." | 3.69 | Melatonin inhibits growth of cultured human uveal melanoma cells. ( Hu, DN; Roberts, JE, 1997) |
| "Increasing evidence of the immunomodulatory and tumor-depressing effects of melatonin prompted us to study altered concentrations of this multifunctional pineal hormone in the aqueous humor of eyes with melanoma." | 3.68 | [The role of melatonin in growth of malignant choroid melanoma]. ( Gupta, D; Heinze, J; Rohrbach, JM; Thanos, S; Wollmann, H, 1993) |
| "In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line." | 3.68 | Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin. ( Crocker, C; Niles, LP; Ying, SW, 1993) |
| "In 19 patients with malignant melanoma of the choroid and 11 controls 20 different metabolic parameters of melanin and melatonin metabolism in urine were examined by high-pressure liquid chromatography (HPLC)." | 3.67 | [HPLC detection of pathologic metabolites of melanin and melatonin metabolism in the urine in malignant melanoma of the choroid]. ( Dieckhues, B, 1986) |
| "Results are given of daily excretion levels of 6-oxymelatonin, thymic serum factor (FTS), and cortisol in the blood of 140 healthy subjects and 90 patients with skin melanoma, ranging from 20 to 49 years of age." | 3.67 | Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma. ( Grinevich, YA; Labunetz, IF, 1986) |
| "The effect of melatonin on the growth of B16 mice melanoma was examined." | 3.67 | Effect of melatonin on B16 melanoma growth in athymic mice. ( Kudo, H; Narita, T, 1985) |
| "Melatonin acts as a free radical scavenger and thus inhibits the initiation of cancer cell growth." | 3.01 | An exclusive review of melatonin effects on mammalian melanocytes and melanoma. ( Ahmad, N; Mubashshir, M; Ovais, M; Sköld, HN, 2023) |
| "Melatonin has been observed to suppress the growth of cancer cells, inhibit metastatic spread, enhance immune system functions, and act as an anti-inflammatory in both in vitro and in vivo models." | 2.82 | The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature. ( Hagström, A; Kal Omar, R; Stålhammar, G; Williams, PA, 2022) |
| "Melanoma is a less common type of skin cancer yet more aggressive often with a lethal ending." | 2.50 | Running for time: circadian rhythms and melanoma. ( Ilić, N; Jurišić, D; Kraljević Pavelić, S; Markova-Car, EP, 2014) |
| "Melatonin is an endogenous hormone and free radical scavenger that possesses the ability to protect the DNA and to exert anti-proliferative effects in melanoma cells." | 1.72 | Anti-genotoxic and anti-mutagenic effects of melatonin supplementation in a mouse model of melanoma. ( Damiani, AP; de Andrade, VM; de Oliveira, CA; Luciano, JA; Martins Longaretti, L; Pereira, M; Rigo, FK; Rohr, P; Steiner, BT; Strapazzon, G; Trevisan, G; Vilela, TC, 2022) |
| "Melanoma is a leading cause of cancer deaths worldwide." | 1.62 | Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells. ( Bilska, B; Kleszczyński, K; Piotrowska, A; Pyza, E; Reiter, RJ; Schedel, F; Slominski, AT; Stefan, J; Steinbrink, K; Tulic, MK; Zmijewski, M, 2021) |
| "Melatonin and Kiss1 were shown to be nvolved in tumor suppression." | 1.56 | The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. ( Alptekin, D; Kaplan, H; Kasap, H; Lüleyap, U; Pazarci, P; Pelit, A; Singirik, E; Yegani, A; Yilmaz, M, 2020) |
| "Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths." | 1.51 | Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway. ( Chen, M; Deng, W; Fan, W; Hu, Z; Jin, L; Kang, T; Li, J; Li, L; Li, Y; Liu, J; Liu, T; Lu, W; Luo, M; Qiu, H; Tian, C; Yang, L; Zhang, C; Zheng, F; Zheng, Z; Zhu, Q, 2019) |
| "Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions." | 1.40 | Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways. ( Deng, W; Guo, W; Qiu, H; Tang, R; Wang, J; Xiao, Y; Yi, C; Yu, W; Yu, Z; Yuan, Y; Zhang, Y, 2014) |
| "We documented 10,799 incident skin cancers in 68,336 women in the Nurses' Health Study from June 1988 to June 2006 and examined the relationship between rotating night shifts and skin cancer." | 1.37 | Rotating night shifts and risk of skin cancer in the nurses' health study. ( Han, J; Li, TY; Qureshi, AA; Razavi, P; Schernhammer, ES, 2011) |
| "Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties." | 1.36 | Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. ( Cabrera, J; Estévez, F; Loro, J; Negrín, G; Quintana, J; Reiter, RJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (23.33) | 18.7374 |
| 1990's | 15 (25.00) | 18.2507 |
| 2000's | 7 (11.67) | 29.6817 |
| 2010's | 15 (25.00) | 24.3611 |
| 2020's | 9 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hagström, A | 2 |
| Kal Omar, R | 2 |
| Williams, PA | 1 |
| Stålhammar, G | 2 |
| Mubashshir, M | 3 |
| Ahmad, N | 3 |
| Sköld, HN | 3 |
| Ovais, M | 3 |
| Möller, JKS | 1 |
| Linowiecka, K | 1 |
| Gagat, M | 1 |
| Brożyna, AA | 1 |
| Foksiński, M | 1 |
| Wolnicka-Glubisz, A | 1 |
| Pyza, E | 3 |
| Reiter, RJ | 7 |
| Tulic, MK | 2 |
| Slominski, AT | 7 |
| Steinbrink, K | 3 |
| Kleszczyński, K | 5 |
| Kim, TK | 4 |
| Bilska, B | 2 |
| Sarna, M | 1 |
| Mokrzynski, K | 1 |
| Stegemann, A | 1 |
| Böhm, M | 2 |
| Martins Longaretti, L | 1 |
| Luciano, JA | 1 |
| Strapazzon, G | 1 |
| Pereira, M | 1 |
| Damiani, AP | 1 |
| Rohr, P | 1 |
| Rigo, FK | 1 |
| de Oliveira, CA | 1 |
| Steiner, BT | 1 |
| Vilela, TC | 1 |
| Trevisan, G | 1 |
| de Andrade, VM | 1 |
| Pazarci, P | 1 |
| Kaplan, H | 1 |
| Alptekin, D | 1 |
| Yilmaz, M | 1 |
| Lüleyap, U | 1 |
| Singirik, E | 1 |
| Pelit, A | 1 |
| Kasap, H | 1 |
| Yegani, A | 1 |
| Schedel, F | 1 |
| Piotrowska, A | 1 |
| Stefan, J | 1 |
| Zmijewski, M | 1 |
| Novik, AV | 1 |
| Protsenko, SA | 1 |
| Baldueva, IA | 1 |
| Berstein, LM | 1 |
| Anisimov, VN | 1 |
| Zhuk, IN | 1 |
| Semenova, AI | 1 |
| Latipova, DK | 1 |
| Tkachenko, EV | 1 |
| Semiglazova, TY | 1 |
| Picardo, M | 1 |
| Pourhanifeh, MH | 1 |
| Mahdavinia, M | 1 |
| Asemi, Z | 1 |
| Hao, J | 1 |
| Fan, W | 2 |
| Li, Y | 2 |
| Tang, R | 2 |
| Tian, C | 2 |
| Yang, Q | 1 |
| Zhu, T | 1 |
| Diao, C | 1 |
| Hu, S | 1 |
| Chen, M | 4 |
| Guo, P | 1 |
| Long, Q | 1 |
| Zhang, C | 2 |
| Qin, G | 1 |
| Yu, W | 2 |
| Li, L | 2 |
| Qin, L | 1 |
| Wang, J | 2 |
| Zhang, X | 1 |
| Ren, Y | 1 |
| Zhou, P | 1 |
| Zou, L | 1 |
| Jiang, K | 1 |
| Guo, W | 2 |
| Deng, W | 3 |
| Liu, T | 1 |
| Jin, L | 1 |
| Zheng, Z | 1 |
| Lu, W | 1 |
| Zheng, F | 1 |
| Zhu, Q | 1 |
| Qiu, H | 2 |
| Liu, J | 1 |
| Hu, Z | 1 |
| Luo, M | 1 |
| Li, J | 1 |
| Kang, T | 1 |
| Yang, L | 1 |
| Janjetovic, Z | 1 |
| Sweatman, T | 3 |
| Lin, Z | 3 |
| Li, W | 4 |
| Fischer, TW | 2 |
| Markova-Car, EP | 1 |
| Jurišić, D | 1 |
| Ilić, N | 1 |
| Kraljević Pavelić, S | 1 |
| Yi, C | 1 |
| Zhang, Y | 1 |
| Yu, Z | 1 |
| Xiao, Y | 1 |
| Yuan, Y | 1 |
| Tidwell, WJ | 1 |
| Gutierrez, D | 1 |
| Arbesman, J | 1 |
| van der Rhee, HJ | 1 |
| de Vries, E | 1 |
| Coebergh, JW | 1 |
| Kvaskoff, M | 1 |
| Weinstein, P | 1 |
| Cabrera, J | 1 |
| Negrín, G | 1 |
| Estévez, F | 1 |
| Loro, J | 1 |
| Quintana, J | 1 |
| Schernhammer, ES | 1 |
| Razavi, P | 1 |
| Li, TY | 1 |
| Qureshi, AA | 1 |
| Han, J | 1 |
| Souza, AV | 1 |
| Visconti, MA | 1 |
| Castrucci, AM | 3 |
| Kiratli, H | 1 |
| Gedik, S | 1 |
| Us, D | 1 |
| Bilgiç, S | 1 |
| Kadekaro, AL | 1 |
| Andrade, LN | 1 |
| Floeter-Winter, LM | 1 |
| Rollag, MD | 1 |
| Virador, V | 1 |
| Vieira, W | 1 |
| Zmijewski, MA | 1 |
| Zbytek, B | 1 |
| Sweatman, TW | 1 |
| Slominski, RM | 1 |
| Wortsman, J | 3 |
| Slominski, A | 3 |
| Labunets, IF | 1 |
| Grinevich, IuA | 1 |
| Knysh, IT | 1 |
| Vasiliuk, AN | 1 |
| Matsumoto, J | 1 |
| Ishikawa, T | 1 |
| Masahito, P | 1 |
| Takayama, S | 1 |
| Taylor, JD | 1 |
| Tchen, TT | 1 |
| Meyskens, FL | 1 |
| Salmon, SE | 1 |
| Stanberry, LR | 1 |
| Das Gupta, TK | 4 |
| Beattie, CW | 1 |
| Kane, MA | 2 |
| Johnson, A | 1 |
| Nash, AE | 1 |
| Boose, D | 1 |
| Mathai, G | 1 |
| Balmer, C | 1 |
| Yohn, JJ | 1 |
| Robinson, WA | 1 |
| Iyengar, B | 1 |
| Helton, RA | 1 |
| Harrison, WA | 1 |
| Kelley, K | 1 |
| Zhen, B | 1 |
| Murphy, JR | 1 |
| Lissoni, P | 2 |
| Barni, S | 2 |
| Tancini, G | 2 |
| Ardizzoia, A | 1 |
| Ricci, G | 1 |
| Aldeghi, R | 1 |
| Brivio, F | 2 |
| Tisi, E | 1 |
| Rovelli, F | 1 |
| Rescaldani, R | 1 |
| Rohrbach, JM | 1 |
| Wollmann, H | 1 |
| Heinze, J | 1 |
| Gupta, D | 1 |
| Thanos, S | 1 |
| Ying, SW | 1 |
| Niles, LP | 1 |
| Crocker, C | 1 |
| Cohn, BA | 1 |
| Brivio, O | 1 |
| Crippa, D | 1 |
| Meregalli, S | 1 |
| Hu, DN | 3 |
| Roberts, JE | 3 |
| Almeida, AL | 1 |
| al-Obeidi, FA | 1 |
| Hadley, ME | 1 |
| Hruby, VJ | 1 |
| Staples, DJ | 1 |
| Sawyer, TK | 1 |
| Hill, HZ | 1 |
| Bubis, M | 1 |
| Zisapel, N | 1 |
| McCormick, SA | 1 |
| Wiechmann, AF | 1 |
| Semak, I | 2 |
| Pisarchik, A | 2 |
| Szczesniewski, A | 2 |
| Slugocki, G | 1 |
| McNulty, J | 1 |
| Kauser, S | 1 |
| Tobin, DJ | 1 |
| Jing, C | 1 |
| Johansson, O | 1 |
| El-Domeiri, AA | 3 |
| Fraschini, F | 1 |
| Scaglione, F | 1 |
| Franco, P | 1 |
| Demartini, G | 1 |
| Lucini, V | 1 |
| Stankov, B | 1 |
| Arbesman, H | 1 |
| Byers, T | 1 |
| Miles, A | 1 |
| Philbrick, D | 1 |
| Dieckhues, B | 1 |
| Grinevich, YA | 1 |
| Labunetz, IF | 1 |
| Narita, T | 1 |
| Kudo, H | 1 |
| Strafuss, AC | 1 |
| Dommert, AR | 1 |
| Tumbleson, ME | 1 |
| Middleton, CC | 1 |
| Hu, F | 1 |
| Ghosh, BC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Melatonin for Uveal Melanoma: A Randomized Open Phase III Study[NCT05502900] | Phase 3 | 100 participants (Anticipated) | Interventional | 2022-10-02 | Recruiting | ||
| Phase II Multicenter Randomized Study to Compare Dacarbazine With Melatonin or Metformin Versus Dacarbazine in the First Line Therapy of Disseminated Melanoma[NCT02190838] | Phase 2 | 57 participants (Actual) | Interventional | 2014-04-30 | Terminated (stopped due to Preliminary terminated due to inefficacy) | ||
| Role of Peripheral Serotonin in Oculocutaneous Albinism[NCT06138509] | 160 participants (Anticipated) | Observational | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for melatonin and Melanoma
| Article | Year |
|---|---|
The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature.
Topics: Humans; Melanoma; Melatonin; Uveal Neoplasms | 2022 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
Potential use of melatonin in skin cancer treatment: A review of current biological evidence.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Humans; Melanoma; Melatonin; Oxidative Stress; React | 2019 |
Running for time: circadian rhythms and melanoma.
Topics: Arylalkylamine N-Acetyltransferase; Circadian Rhythm; Gene Expression Regulation, Neoplastic; Humans | 2014 |
Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer.
Topics: Circadian Rhythm; CLOCK Proteins; DNA Damage; DNA Repair; Gene Expression; Humans; Melanoma; Melaton | 2016 |
Melatonin and the skin: from frog to human.
Topics: Amphibians; Animals; Humans; Melanoma; Melatonin; Skin Neoplasms; Skin Pigmentation | 1996 |
Melatonin: perspectives in laboratory medicine and clinical research.
Topics: Brain Neoplasms; Breast Neoplasms; Humans; Male; Melanoma; Melatonin; Mood Disorders; Prostatic Neop | 1987 |
4 trials available for melatonin and Melanoma
| Article | Year |
|---|---|
Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study.
Topics: Adult; Clinical Trials, Phase III as Topic; Humans; Melanoma; Melatonin; Randomized Controlled Trial | 2023 |
Serum melatonin levels in melanoma patients after repeated oral administration.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Circadian Rhythm; Female; Humans; | 1994 |
A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Colorec | 1994 |
Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Stu | 1996 |
49 other studies available for melatonin and Melanoma
| Article | Year |
|---|---|
Melanogenesis Is Directly Affected by Metabolites of Melatonin in Human Melanoma Cells.
Topics: 5-Methoxytryptamine; Humans; Melanins; Melanoma; Melatonin; Monophenol Monooxygenase; Receptor, Mela | 2023 |
Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT-1 melanoma cells.
Topics: Cell Line, Tumor; Cell Survival; Humans; Melanins; Melanoma; Melatonin; Pigmentation Disorders | 2019 |
Anti-genotoxic and anti-mutagenic effects of melatonin supplementation in a mouse model of melanoma.
Topics: Animals; Antimutagenic Agents; Comet Assay; Dietary Supplements; DNA Damage; Male; Melanoma; Melaton | 2022 |
The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice.
Topics: Animals; Animals, Newborn; Female; Gene Expression Regulation; Hypothalamus; Kisspeptins; Melanoma; | 2020 |
Can melatonin and its metabolites boost the efficacy of targeted therapy in patients with advanced melanoma?
Topics: Antineoplastic Agents; Drug Therapy, Combination; Humans; Melanoma; Melatonin; Mitogen-Activated Pro | 2020 |
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells.
Topics: Antineoplastic Agents; Biotransformation; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; H | 2021 |
Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Humans; Melanoma; Melatonin; Metformin; | 2021 |
Melanin pigmentation and melanoma.
Topics: DNA Damage; Humans; Melanins; Melanocytes; Melanoma; Melatonin; Neoplasm Metastasis; Oxidants; Pigme | 2017 |
Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apopto | 2019 |
Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Fema | 2019 |
Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.
Topics: 5-Methoxytryptamine; Animals; Cell Differentiation; Cell Line; Cell Line, Tumor; Cells, Cultured; Ch | 2013 |
Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenas | 2014 |
Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro.
Topics: 5-Methoxytryptamine; Adult; Age Factors; Aged; Aged, 80 and over; Black or African American; Cell Pr | 2015 |
N1-Acetyl-5-Methoxykynuramine (AMK) is produced in the human epidermis and shows antiproliferative effects.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Black or African American; Cell Line; Cell Line, Tumor; | 2015 |
Regular sun exposure benefits health.
Topics: Animals; Circadian Rhythm; Environmental Exposure; Europe; Female; Health; Humans; Male; Melanoma; M | 2016 |
Are some melanomas caused by artificial light?
Topics: Global Health; Humans; Incidence; Lighting; Melanoma; Melatonin; Risk Factors; Skin Neoplasms | 2010 |
Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells.
Topics: Cell Line, Tumor; Cell Proliferation; Diterpenes; Humans; Melanoma; Melatonin; p38 Mitogen-Activated | 2010 |
Rotating night shifts and risk of skin cancer in the nurses' health study.
Topics: Adult; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Confounding Factors, Epidemiologic; Female; | 2011 |
Melatonin biological activity and binding sites in human melanoma cells.
Topics: Binding Sites; Binding, Competitive; Cell Division; Humans; Iodine Radioisotopes; Melanoma; Melatoni | 2003 |
Serum melatonin levels following enucleation and transpupillary thermotherapy in patients with choroidal melanoma.
Topics: Adult; Aged; Choroid Neoplasms; Enzyme-Linked Immunosorbent Assay; Eye Enucleation; Humans; Hyperthe | 2003 |
MT-1 melatonin receptor expression increases the antiproliferative effect of melatonin on S-91 murine melanoma cells.
Topics: Animals; Antineoplastic Agents; Binding Sites; Catalase; Cell Division; Colforsin; Cyclic AMP; Dose- | 2004 |
Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines.
Topics: Cell Nucleus; Cell Proliferation; Culture Media, Serum-Free; Cytosol; Free Radical Scavengers; Gene | 2006 |
[Functional characteristics of the endocrine glands in skin melanoma patients].
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Female; Humans; Hydrocortisone; Male; Melanocyte | 1984 |
Clonal heterogeneity in physiological properties of melanized cells induced from goldfish erythrophoroma cell lines.
Topics: Animals; Cell Differentiation; Cell Line; Clone Cells; Cyprinidae; Epinephrine; Goldfish; Melanocyte | 1984 |
Modulation of clonogenic human melanoma cells by follicle-stimulating hormone, melatonin, and nerve growth factor.
Topics: Clone Cells; Follicle Stimulating Hormone; Humans; Melanoma; Melatonin; Nerve Growth Factors | 1981 |
Photoperiodic control of melanoma growth in hamsters: influence of pinealectomy and melatonin.
Topics: Adrenal Glands; Androgens; Animals; Cell Division; Cricetinae; Darkness; Epididymis; Light; Luteiniz | 1983 |
Indoleamines and the UV-light-sensitive photoperiodic responses of the melanocyte network: a biological calendar?
Topics: Biopsy; Circadian Rhythm; Humans; Immunohistochemistry; Keratosis, Seborrheic; Melanocytes; Melanoma | 1994 |
Melatonin interactions with cultured murine B16 melanoma cells.
Topics: Animals; Biological Transport; Cell Division; Estradiol; Humans; Melanoma; Melanoma, Experimental; M | 1993 |
Sample size determination for an exponential survival model with an unrestricted covariate.
Topics: Computer Simulation; Factor Analysis, Statistical; Humans; Mathematical Computing; Melanoma; Melaton | 1994 |
[The role of melatonin in growth of malignant choroid melanoma].
Topics: Aqueous Humor; Cell Division; Choroid Neoplasms; Enzyme-Linked Immunosorbent Assay; Eye Enucleation; | 1993 |
Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin.
Topics: Adenylyl Cyclase Inhibitors; Cell Division; Cell Membrane; Colforsin; Cyclic AMP; DNA, Neoplasm; Hum | 1993 |
Melatonin inhibits growth of cultured human uveal melanoma cells.
Topics: Bromodeoxyuridine; Cell Division; Humans; Liver Neoplasms; Melanoma; Melatonin; Tumor Cells, Culture | 1997 |
Comparative biological activities of alpha-MSH antagonists in vertebrate pigment cells.
Topics: alpha-MSH; Amino Acid Sequence; Animals; Bufonidae; Cell Division; Fishes; Lizards; Melanocytes; Mel | 1997 |
Induced melanin reduces mutations and cell killing in mouse melanoma.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; DNA Damage; Melanoma; Melatonin; Mice; Mutation; Tu | 1997 |
A role for NAD+ and cADP-ribose in melatonin signal transduction.
Topics: Adenosine Diphosphate Ribose; Cyclic ADP-Ribose; Humans; Melanoma; Melatonin; NAD; Signal Transducti | 1998 |
Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells.
Topics: Cell Division; Dose-Response Relationship, Drug; Humans; Kynurenine; Melanoma; Melatonin; Serotonin; | 1998 |
Melatonin receptors in human uveal melanocytes and melanoma cells.
Topics: Acetamides; Blotting, Southern; Choroid Neoplasms; Dose-Response Relationship, Drug; Gene Expression | 2000 |
Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.
Topics: Acetylserotonin O-Methyltransferase; Chromatography, High Pressure Liquid; Humans; Melanoma; Melaton | 2002 |
Serotoninergic and melatoninergic systems are fully expressed in human skin.
Topics: Acetylserotonin O-Methyltransferase; Arylamine N-Acetyltransferase; Cell Line; Gene Expression; Gene | 2002 |
The influence of pineal ablation and administration of melatonin on growth and spread of hamster melanoma.
Topics: Animals; Cricetinae; Male; Melanoma; Melatonin; Neoplasms, Experimental; Pineal Gland; Time Factors | 1976 |
Melatonin and immunity.
Topics: Animals; Cell Count; Cells, Cultured; Humans; Immunity, Innate; Killer Cells, Natural; Lymphocyte Su | 1990 |
Possible association between breast cancer and malignant melanoma.
Topics: Adrenergic beta-Antagonists; Breast Neoplasms; Female; Humans; Melanoma; Melatonin; Pineal Gland; Ri | 1988 |
[HPLC detection of pathologic metabolites of melanin and melatonin metabolism in the urine in malignant melanoma of the choroid].
Topics: Choroid Neoplasms; Chromatography, High Pressure Liquid; Humans; Melanins; Melanoma; Melatonin | 1986 |
Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma.
Topics: Adrenal Cortex; Adult; Age Factors; Female; Humans; Hydrocortisone; Male; Melanoma; Melatonin; Menst | 1986 |
Effect of melatonin on B16 melanoma growth in athymic mice.
Topics: Adrenal Glands; Animals; Female; Gonads; Male; Melanoma; Melatonin; Mice; Mice, Inbred BALB C; Mice, | 1985 |
Cutaneous melanoma in miniature swine.
Topics: Animals; Animals, Newborn; Melanoma; Melatonin; Skin Neoplasms; Swine; Swine Diseases | 1968 |
The influence of certain hormones and chemicals on mammalian pigment cells.
Topics: Adrenocorticotropic Hormone; Animals; Ascorbic Acid; Chromatophores; Colchicine; Copper; Culture Tec | 1966 |
Reversal by melatonin of the effect of pinealectomy on tumor growth.
Topics: Animals; Cricetinae; Male; Melanoma; Melatonin; Neoplasm Transplantation; Neoplasms, Experimental; P | 1973 |
Effect of melatonin on hamster melanoma.
Topics: Animals; Cricetinae; Ethanol; Male; Melanoma; Melatonin; Neoplasm Transplantation; Pineal Gland; Ski | 1973 |