melatonin has been researched along with Malignant Melanoma in 60 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " One hundred patients recently diagnosed with non-metastatic uveal melanoma will be randomized to either treatment with adjuvant melatonin 20 mg (4 tablets of 5 mg) at 10 pm for 5 years, or to standard follow-up (control group)." | 9.69 | Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study. ( Hagström, A; Kal Omar, R; Stålhammar, G, 2023) |
| "Several experimental studies have shown that melatonin has an oncostatic action, either by stimulating host antitumor immune defenses or by directly inhibiting the growth of some cancer histotypes, including melanoma." | 9.08 | Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. ( Barni, S; Brivio, F; Brivio, O; Crippa, D; Lissoni, P; Meregalli, S; Tancini, G, 1996) |
| " In particular, the association with the pineal neurohormone melatonin (MLT) has been shown to cause tumour regressions in neoplasms that are generally non-responsive to IL-2 alone." | 9.07 | A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Brivio, F; Lissoni, P; Rescaldani, R; Ricci, G; Rovelli, F; Tancini, G; Tisi, E, 1994) |
| "The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma." | 9.07 | Serum melatonin levels in melanoma patients after repeated oral administration. ( Balmer, C; Boose, D; Johnson, A; Kane, MA; Mathai, G; Nash, AE; Robinson, WA; Yohn, JJ, 1994) |
| "Melatonin did not increase the efficacy of systemic chemotherapy in melanoma." | 8.02 | Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma. ( Anisimov, VN; Baldueva, IA; Berstein, LM; Latipova, DK; Novik, AV; Protsenko, SA; Semenova, AI; Semiglazova, TY; Tkachenko, EV; Zhuk, IN, 2021) |
| "Collectively, our results demonstrate melatonin synergizes the antitumor effect of vemurafenib in human melanoma by inhibiting cell proliferation and cancer-stem cell traits via targeting NF-κB/iNOS/hTERT signaling pathway, and suggest the potential of melatonin in antagonizing the toxicity of vemurafenib and augmenting its sensitivities in melanoma treatment." | 7.91 | Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits. ( Chen, M; Deng, W; Diao, C; Fan, W; Guo, P; Guo, W; Hao, J; Hu, S; Jiang, K; Li, L; Li, Y; Long, Q; Qin, G; Qin, L; Ren, Y; Tang, R; Tian, C; Wang, J; Yang, Q; Yu, W; Zhang, C; Zhang, X; Zhou, P; Zhu, T; Zou, L, 2019) |
| "Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo." | 7.73 | Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines. ( Fischer, TW; Slominski, A; Slominski, RM; Sweatman, TW; Wortsman, J; Zbytek, B; Zmijewski, MA, 2006) |
| "Patients with choroidal melanomas had higher levels of serum melatonin compared to individuals without tumours." | 7.72 | Serum melatonin levels following enucleation and transpupillary thermotherapy in patients with choroidal melanoma. ( Bilgiç, S; Gedik, S; Kiratli, H; Us, D, 2003) |
| "The effects of melatonin, N-acetylserotonin and serotonin on the growth and tyrosinase activity of SK-Mel 23 and SK-Mel 28 human melanoma cell lines were investigated." | 7.72 | Melatonin biological activity and binding sites in human melanoma cells. ( Castrucci, AM; Souza, AV; Visconti, MA, 2003) |
| "We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase." | 7.71 | Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. ( Pisarchik, A; Semak, I; Slominski, A; Sweatman, T; Szczesniewski, A; Wortsman, J, 2002) |
| "Previous work has demonstrated that melatonin inhibits growth of cultured human uveal melanoma cells." | 7.70 | Melatonin receptors in human uveal melanocytes and melanoma cells. ( Hu, DN; Roberts, JE; Wiechmann, AF, 2000) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 7.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "The effects of melatonin on the growth of human uveal melanoma cells were studied in vitro." | 7.69 | Melatonin inhibits growth of cultured human uveal melanoma cells. ( Hu, DN; Roberts, JE, 1997) |
| "In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line." | 7.68 | Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin. ( Crocker, C; Niles, LP; Ying, SW, 1993) |
| "Increasing evidence of the immunomodulatory and tumor-depressing effects of melatonin prompted us to study altered concentrations of this multifunctional pineal hormone in the aqueous humor of eyes with melanoma." | 7.68 | [The role of melatonin in growth of malignant choroid melanoma]. ( Gupta, D; Heinze, J; Rohrbach, JM; Thanos, S; Wollmann, H, 1993) |
| "The effect of melatonin on the growth of B16 mice melanoma was examined." | 7.67 | Effect of melatonin on B16 melanoma growth in athymic mice. ( Kudo, H; Narita, T, 1985) |
| "In 19 patients with malignant melanoma of the choroid and 11 controls 20 different metabolic parameters of melanin and melatonin metabolism in urine were examined by high-pressure liquid chromatography (HPLC)." | 7.67 | [HPLC detection of pathologic metabolites of melanin and melatonin metabolism in the urine in malignant melanoma of the choroid]. ( Dieckhues, B, 1986) |
| "Results are given of daily excretion levels of 6-oxymelatonin, thymic serum factor (FTS), and cortisol in the blood of 140 healthy subjects and 90 patients with skin melanoma, ranging from 20 to 49 years of age." | 7.67 | Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma. ( Grinevich, YA; Labunetz, IF, 1986) |
| "Melatonin acts as a free radical scavenger and thus inhibits the initiation of cancer cell growth." | 7.01 | An exclusive review of melatonin effects on mammalian melanocytes and melanoma. ( Ahmad, N; Mubashshir, M; Ovais, M; Sköld, HN, 2023) |
| "Melatonin has been observed to suppress the growth of cancer cells, inhibit metastatic spread, enhance immune system functions, and act as an anti-inflammatory in both in vitro and in vivo models." | 6.82 | The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature. ( Hagström, A; Kal Omar, R; Stålhammar, G; Williams, PA, 2022) |
| "Melatonin is an endogenous hormone and free radical scavenger that possesses the ability to protect the DNA and to exert anti-proliferative effects in melanoma cells." | 5.72 | Anti-genotoxic and anti-mutagenic effects of melatonin supplementation in a mouse model of melanoma. ( Damiani, AP; de Andrade, VM; de Oliveira, CA; Luciano, JA; Martins Longaretti, L; Pereira, M; Rigo, FK; Rohr, P; Steiner, BT; Strapazzon, G; Trevisan, G; Vilela, TC, 2022) |
| " One hundred patients recently diagnosed with non-metastatic uveal melanoma will be randomized to either treatment with adjuvant melatonin 20 mg (4 tablets of 5 mg) at 10 pm for 5 years, or to standard follow-up (control group)." | 5.69 | Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study. ( Hagström, A; Kal Omar, R; Stålhammar, G, 2023) |
| "Melanoma is a leading cause of cancer deaths worldwide." | 5.62 | Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells. ( Bilska, B; Kleszczyński, K; Piotrowska, A; Pyza, E; Reiter, RJ; Schedel, F; Slominski, AT; Stefan, J; Steinbrink, K; Tulic, MK; Zmijewski, M, 2021) |
| "Melatonin and Kiss1 were shown to be nvolved in tumor suppression." | 5.56 | The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. ( Alptekin, D; Kaplan, H; Kasap, H; Lüleyap, U; Pazarci, P; Pelit, A; Singirik, E; Yegani, A; Yilmaz, M, 2020) |
| "Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths." | 5.51 | Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway. ( Chen, M; Deng, W; Fan, W; Hu, Z; Jin, L; Kang, T; Li, J; Li, L; Li, Y; Liu, J; Liu, T; Lu, W; Luo, M; Qiu, H; Tian, C; Yang, L; Zhang, C; Zheng, F; Zheng, Z; Zhu, Q, 2019) |
| "Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties." | 5.36 | Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. ( Cabrera, J; Estévez, F; Loro, J; Negrín, G; Quintana, J; Reiter, RJ, 2010) |
| "Several experimental studies have shown that melatonin has an oncostatic action, either by stimulating host antitumor immune defenses or by directly inhibiting the growth of some cancer histotypes, including melanoma." | 5.08 | Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. ( Barni, S; Brivio, F; Brivio, O; Crippa, D; Lissoni, P; Meregalli, S; Tancini, G, 1996) |
| "The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma." | 5.07 | Serum melatonin levels in melanoma patients after repeated oral administration. ( Balmer, C; Boose, D; Johnson, A; Kane, MA; Mathai, G; Nash, AE; Robinson, WA; Yohn, JJ, 1994) |
| " In particular, the association with the pineal neurohormone melatonin (MLT) has been shown to cause tumour regressions in neoplasms that are generally non-responsive to IL-2 alone." | 5.07 | A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. ( Aldeghi, R; Ardizzoia, A; Barni, S; Brivio, F; Lissoni, P; Rescaldani, R; Ricci, G; Rovelli, F; Tancini, G; Tisi, E, 1994) |
| "Melatonin did not increase the efficacy of systemic chemotherapy in melanoma." | 4.02 | Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma. ( Anisimov, VN; Baldueva, IA; Berstein, LM; Latipova, DK; Novik, AV; Protsenko, SA; Semenova, AI; Semiglazova, TY; Tkachenko, EV; Zhuk, IN, 2021) |
| "Collectively, our results demonstrate melatonin synergizes the antitumor effect of vemurafenib in human melanoma by inhibiting cell proliferation and cancer-stem cell traits via targeting NF-κB/iNOS/hTERT signaling pathway, and suggest the potential of melatonin in antagonizing the toxicity of vemurafenib and augmenting its sensitivities in melanoma treatment." | 3.91 | Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits. ( Chen, M; Deng, W; Diao, C; Fan, W; Guo, P; Guo, W; Hao, J; Hu, S; Jiang, K; Li, L; Li, Y; Long, Q; Qin, G; Qin, L; Ren, Y; Tang, R; Tian, C; Wang, J; Yang, Q; Yu, W; Zhang, C; Zhang, X; Zhou, P; Zhu, T; Zou, L, 2019) |
| "Indolic and kynuric pathways of skin melatonin metabolism were monitored by liquid chromatography mass spectrometry in human keratinocytes, melanocytes, dermal fibroblasts, and melanoma cells." | 3.79 | Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. ( Fischer, TW; Janjetovic, Z; Kim, TK; Kleszczynski, K; Li, W; Lin, Z; Reiter, RJ; Slominski, AT; Sweatman, T, 2013) |
| "Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo." | 3.73 | Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines. ( Fischer, TW; Slominski, A; Slominski, RM; Sweatman, TW; Wortsman, J; Zbytek, B; Zmijewski, MA, 2006) |
| "Patients with choroidal melanomas had higher levels of serum melatonin compared to individuals without tumours." | 3.72 | Serum melatonin levels following enucleation and transpupillary thermotherapy in patients with choroidal melanoma. ( Bilgiç, S; Gedik, S; Kiratli, H; Us, D, 2003) |
| "The effects of melatonin, N-acetylserotonin and serotonin on the growth and tyrosinase activity of SK-Mel 23 and SK-Mel 28 human melanoma cell lines were investigated." | 3.72 | Melatonin biological activity and binding sites in human melanoma cells. ( Castrucci, AM; Souza, AV; Visconti, MA, 2003) |
| "We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase." | 3.71 | Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. ( Pisarchik, A; Semak, I; Slominski, A; Sweatman, T; Szczesniewski, A; Wortsman, J, 2002) |
| "The hormone melatonin modulates constitutive protein secretion and inhibits cGMP in melanoma M2R cells via cholera-toxin (CTX) sensitive pathways." | 3.70 | A role for NAD+ and cADP-ribose in melatonin signal transduction. ( Bubis, M; Zisapel, N, 1998) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 3.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "Previous work has demonstrated that melatonin inhibits growth of cultured human uveal melanoma cells." | 3.70 | Melatonin receptors in human uveal melanocytes and melanoma cells. ( Hu, DN; Roberts, JE; Wiechmann, AF, 2000) |
| "The effects of melatonin on the growth of human uveal melanoma cells were studied in vitro." | 3.69 | Melatonin inhibits growth of cultured human uveal melanoma cells. ( Hu, DN; Roberts, JE, 1997) |
| "Increasing evidence of the immunomodulatory and tumor-depressing effects of melatonin prompted us to study altered concentrations of this multifunctional pineal hormone in the aqueous humor of eyes with melanoma." | 3.68 | [The role of melatonin in growth of malignant choroid melanoma]. ( Gupta, D; Heinze, J; Rohrbach, JM; Thanos, S; Wollmann, H, 1993) |
| "In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line." | 3.68 | Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin. ( Crocker, C; Niles, LP; Ying, SW, 1993) |
| "In 19 patients with malignant melanoma of the choroid and 11 controls 20 different metabolic parameters of melanin and melatonin metabolism in urine were examined by high-pressure liquid chromatography (HPLC)." | 3.67 | [HPLC detection of pathologic metabolites of melanin and melatonin metabolism in the urine in malignant melanoma of the choroid]. ( Dieckhues, B, 1986) |
| "Results are given of daily excretion levels of 6-oxymelatonin, thymic serum factor (FTS), and cortisol in the blood of 140 healthy subjects and 90 patients with skin melanoma, ranging from 20 to 49 years of age." | 3.67 | Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma. ( Grinevich, YA; Labunetz, IF, 1986) |
| "The effect of melatonin on the growth of B16 mice melanoma was examined." | 3.67 | Effect of melatonin on B16 melanoma growth in athymic mice. ( Kudo, H; Narita, T, 1985) |
| "Melatonin acts as a free radical scavenger and thus inhibits the initiation of cancer cell growth." | 3.01 | An exclusive review of melatonin effects on mammalian melanocytes and melanoma. ( Ahmad, N; Mubashshir, M; Ovais, M; Sköld, HN, 2023) |
| "Melatonin has been observed to suppress the growth of cancer cells, inhibit metastatic spread, enhance immune system functions, and act as an anti-inflammatory in both in vitro and in vivo models." | 2.82 | The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature. ( Hagström, A; Kal Omar, R; Stålhammar, G; Williams, PA, 2022) |
| "Melanoma is a less common type of skin cancer yet more aggressive often with a lethal ending." | 2.50 | Running for time: circadian rhythms and melanoma. ( Ilić, N; Jurišić, D; Kraljević Pavelić, S; Markova-Car, EP, 2014) |
| "Melatonin is an endogenous hormone and free radical scavenger that possesses the ability to protect the DNA and to exert anti-proliferative effects in melanoma cells." | 1.72 | Anti-genotoxic and anti-mutagenic effects of melatonin supplementation in a mouse model of melanoma. ( Damiani, AP; de Andrade, VM; de Oliveira, CA; Luciano, JA; Martins Longaretti, L; Pereira, M; Rigo, FK; Rohr, P; Steiner, BT; Strapazzon, G; Trevisan, G; Vilela, TC, 2022) |
| "Melanoma is a leading cause of cancer deaths worldwide." | 1.62 | Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells. ( Bilska, B; Kleszczyński, K; Piotrowska, A; Pyza, E; Reiter, RJ; Schedel, F; Slominski, AT; Stefan, J; Steinbrink, K; Tulic, MK; Zmijewski, M, 2021) |
| "Melatonin and Kiss1 were shown to be nvolved in tumor suppression." | 1.56 | The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. ( Alptekin, D; Kaplan, H; Kasap, H; Lüleyap, U; Pazarci, P; Pelit, A; Singirik, E; Yegani, A; Yilmaz, M, 2020) |
| "Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths." | 1.51 | Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway. ( Chen, M; Deng, W; Fan, W; Hu, Z; Jin, L; Kang, T; Li, J; Li, L; Li, Y; Liu, J; Liu, T; Lu, W; Luo, M; Qiu, H; Tian, C; Yang, L; Zhang, C; Zheng, F; Zheng, Z; Zhu, Q, 2019) |
| "Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions." | 1.40 | Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways. ( Deng, W; Guo, W; Qiu, H; Tang, R; Wang, J; Xiao, Y; Yi, C; Yu, W; Yu, Z; Yuan, Y; Zhang, Y, 2014) |
| "We documented 10,799 incident skin cancers in 68,336 women in the Nurses' Health Study from June 1988 to June 2006 and examined the relationship between rotating night shifts and skin cancer." | 1.37 | Rotating night shifts and risk of skin cancer in the nurses' health study. ( Han, J; Li, TY; Qureshi, AA; Razavi, P; Schernhammer, ES, 2011) |
| "Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties." | 1.36 | Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. ( Cabrera, J; Estévez, F; Loro, J; Negrín, G; Quintana, J; Reiter, RJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (23.33) | 18.7374 |
| 1990's | 15 (25.00) | 18.2507 |
| 2000's | 7 (11.67) | 29.6817 |
| 2010's | 15 (25.00) | 24.3611 |
| 2020's | 9 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hagström, A | 2 |
| Kal Omar, R | 2 |
| Williams, PA | 1 |
| Stålhammar, G | 2 |
| Mubashshir, M | 3 |
| Ahmad, N | 3 |
| Sköld, HN | 3 |
| Ovais, M | 3 |
| Möller, JKS | 1 |
| Linowiecka, K | 1 |
| Gagat, M | 1 |
| Brożyna, AA | 1 |
| Foksiński, M | 1 |
| Wolnicka-Glubisz, A | 1 |
| Pyza, E | 3 |
| Reiter, RJ | 7 |
| Tulic, MK | 2 |
| Slominski, AT | 7 |
| Steinbrink, K | 3 |
| Kleszczyński, K | 5 |
| Kim, TK | 4 |
| Bilska, B | 2 |
| Sarna, M | 1 |
| Mokrzynski, K | 1 |
| Stegemann, A | 1 |
| Böhm, M | 2 |
| Martins Longaretti, L | 1 |
| Luciano, JA | 1 |
| Strapazzon, G | 1 |
| Pereira, M | 1 |
| Damiani, AP | 1 |
| Rohr, P | 1 |
| Rigo, FK | 1 |
| de Oliveira, CA | 1 |
| Steiner, BT | 1 |
| Vilela, TC | 1 |
| Trevisan, G | 1 |
| de Andrade, VM | 1 |
| Pazarci, P | 1 |
| Kaplan, H | 1 |
| Alptekin, D | 1 |
| Yilmaz, M | 1 |
| Lüleyap, U | 1 |
| Singirik, E | 1 |
| Pelit, A | 1 |
| Kasap, H | 1 |
| Yegani, A | 1 |
| Schedel, F | 1 |
| Piotrowska, A | 1 |
| Stefan, J | 1 |
| Zmijewski, M | 1 |
| Novik, AV | 1 |
| Protsenko, SA | 1 |
| Baldueva, IA | 1 |
| Berstein, LM | 1 |
| Anisimov, VN | 1 |
| Zhuk, IN | 1 |
| Semenova, AI | 1 |
| Latipova, DK | 1 |
| Tkachenko, EV | 1 |
| Semiglazova, TY | 1 |
| Picardo, M | 1 |
| Pourhanifeh, MH | 1 |
| Mahdavinia, M | 1 |
| Asemi, Z | 1 |
| Hao, J | 1 |
| Fan, W | 2 |
| Li, Y | 2 |
| Tang, R | 2 |
| Tian, C | 2 |
| Yang, Q | 1 |
| Zhu, T | 1 |
| Diao, C | 1 |
| Hu, S | 1 |
| Chen, M | 4 |
| Guo, P | 1 |
| Long, Q | 1 |
| Zhang, C | 2 |
| Qin, G | 1 |
| Yu, W | 2 |
| Li, L | 2 |
| Qin, L | 1 |
| Wang, J | 2 |
| Zhang, X | 1 |
| Ren, Y | 1 |
| Zhou, P | 1 |
| Zou, L | 1 |
| Jiang, K | 1 |
| Guo, W | 2 |
| Deng, W | 3 |
| Liu, T | 1 |
| Jin, L | 1 |
| Zheng, Z | 1 |
| Lu, W | 1 |
| Zheng, F | 1 |
| Zhu, Q | 1 |
| Qiu, H | 2 |
| Liu, J | 1 |
| Hu, Z | 1 |
| Luo, M | 1 |
| Li, J | 1 |
| Kang, T | 1 |
| Yang, L | 1 |
| Janjetovic, Z | 1 |
| Sweatman, T | 3 |
| Lin, Z | 3 |
| Li, W | 4 |
| Fischer, TW | 2 |
| Markova-Car, EP | 1 |
| Jurišić, D | 1 |
| Ilić, N | 1 |
| Kraljević Pavelić, S | 1 |
| Yi, C | 1 |
| Zhang, Y | 1 |
| Yu, Z | 1 |
| Xiao, Y | 1 |
| Yuan, Y | 1 |
| Tidwell, WJ | 1 |
| Gutierrez, D | 1 |
| Arbesman, J | 1 |
| van der Rhee, HJ | 1 |
| de Vries, E | 1 |
| Coebergh, JW | 1 |
| Kvaskoff, M | 1 |
| Weinstein, P | 1 |
| Cabrera, J | 1 |
| Negrín, G | 1 |
| Estévez, F | 1 |
| Loro, J | 1 |
| Quintana, J | 1 |
| Schernhammer, ES | 1 |
| Razavi, P | 1 |
| Li, TY | 1 |
| Qureshi, AA | 1 |
| Han, J | 1 |
| Souza, AV | 1 |
| Visconti, MA | 1 |
| Castrucci, AM | 3 |
| Kiratli, H | 1 |
| Gedik, S | 1 |
| Us, D | 1 |
| Bilgiç, S | 1 |
| Kadekaro, AL | 1 |
| Andrade, LN | 1 |
| Floeter-Winter, LM | 1 |
| Rollag, MD | 1 |
| Virador, V | 1 |
| Vieira, W | 1 |
| Zmijewski, MA | 1 |
| Zbytek, B | 1 |
| Sweatman, TW | 1 |
| Slominski, RM | 1 |
| Wortsman, J | 3 |
| Slominski, A | 3 |
| Labunets, IF | 1 |
| Grinevich, IuA | 1 |
| Knysh, IT | 1 |
| Vasiliuk, AN | 1 |
| Matsumoto, J | 1 |
| Ishikawa, T | 1 |
| Masahito, P | 1 |
| Takayama, S | 1 |
| Taylor, JD | 1 |
| Tchen, TT | 1 |
| Meyskens, FL | 1 |
| Salmon, SE | 1 |
| Stanberry, LR | 1 |
| Das Gupta, TK | 4 |
| Beattie, CW | 1 |
| Kane, MA | 2 |
| Johnson, A | 1 |
| Nash, AE | 1 |
| Boose, D | 1 |
| Mathai, G | 1 |
| Balmer, C | 1 |
| Yohn, JJ | 1 |
| Robinson, WA | 1 |
| Iyengar, B | 1 |
| Helton, RA | 1 |
| Harrison, WA | 1 |
| Kelley, K | 1 |
| Zhen, B | 1 |
| Murphy, JR | 1 |
| Lissoni, P | 2 |
| Barni, S | 2 |
| Tancini, G | 2 |
| Ardizzoia, A | 1 |
| Ricci, G | 1 |
| Aldeghi, R | 1 |
| Brivio, F | 2 |
| Tisi, E | 1 |
| Rovelli, F | 1 |
| Rescaldani, R | 1 |
| Rohrbach, JM | 1 |
| Wollmann, H | 1 |
| Heinze, J | 1 |
| Gupta, D | 1 |
| Thanos, S | 1 |
| Ying, SW | 1 |
| Niles, LP | 1 |
| Crocker, C | 1 |
| Cohn, BA | 1 |
| Brivio, O | 1 |
| Crippa, D | 1 |
| Meregalli, S | 1 |
| Hu, DN | 3 |
| Roberts, JE | 3 |
| Almeida, AL | 1 |
| al-Obeidi, FA | 1 |
| Hadley, ME | 1 |
| Hruby, VJ | 1 |
| Staples, DJ | 1 |
| Sawyer, TK | 1 |
| Hill, HZ | 1 |
| Bubis, M | 1 |
| Zisapel, N | 1 |
| McCormick, SA | 1 |
| Wiechmann, AF | 1 |
| Semak, I | 2 |
| Pisarchik, A | 2 |
| Szczesniewski, A | 2 |
| Slugocki, G | 1 |
| McNulty, J | 1 |
| Kauser, S | 1 |
| Tobin, DJ | 1 |
| Jing, C | 1 |
| Johansson, O | 1 |
| El-Domeiri, AA | 3 |
| Fraschini, F | 1 |
| Scaglione, F | 1 |
| Franco, P | 1 |
| Demartini, G | 1 |
| Lucini, V | 1 |
| Stankov, B | 1 |
| Arbesman, H | 1 |
| Byers, T | 1 |
| Miles, A | 1 |
| Philbrick, D | 1 |
| Dieckhues, B | 1 |
| Grinevich, YA | 1 |
| Labunetz, IF | 1 |
| Narita, T | 1 |
| Kudo, H | 1 |
| Strafuss, AC | 1 |
| Dommert, AR | 1 |
| Tumbleson, ME | 1 |
| Middleton, CC | 1 |
| Hu, F | 1 |
| Ghosh, BC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Melatonin for Uveal Melanoma: A Randomized Open Phase III Study[NCT05502900] | Phase 3 | 100 participants (Anticipated) | Interventional | 2022-10-02 | Recruiting | ||
| Phase II Multicenter Randomized Study to Compare Dacarbazine With Melatonin or Metformin Versus Dacarbazine in the First Line Therapy of Disseminated Melanoma[NCT02190838] | Phase 2 | 57 participants (Actual) | Interventional | 2014-04-30 | Terminated (stopped due to Preliminary terminated due to inefficacy) | ||
| Role of Peripheral Serotonin in Oculocutaneous Albinism[NCT06138509] | 160 participants (Anticipated) | Observational | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for melatonin and Malignant Melanoma
| Article | Year |
|---|---|
The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature.
Topics: Humans; Melanoma; Melatonin; Uveal Neoplasms | 2022 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
An exclusive review of melatonin effects on mammalian melanocytes and melanoma.
Topics: Animals; Hair Follicle; Humans; Mammals; Melanocytes; Melanoma; Melatonin; Pigmentation Disorders | 2023 |
Potential use of melatonin in skin cancer treatment: A review of current biological evidence.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Humans; Melanoma; Melatonin; Oxidative Stress; React | 2019 |
Running for time: circadian rhythms and melanoma.
Topics: Arylalkylamine N-Acetyltransferase; Circadian Rhythm; Gene Expression Regulation, Neoplastic; Humans | 2014 |
Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer.
Topics: Circadian Rhythm; CLOCK Proteins; DNA Damage; DNA Repair; Gene Expression; Humans; Melanoma; Melaton | 2016 |
Melatonin and the skin: from frog to human.
Topics: Amphibians; Animals; Humans; Melanoma; Melatonin; Skin Neoplasms; Skin Pigmentation | 1996 |
Melatonin: perspectives in laboratory medicine and clinical research.
Topics: Brain Neoplasms; Breast Neoplasms; Humans; Male; Melanoma; Melatonin; Mood Disorders; Prostatic Neop | 1987 |
4 trials available for melatonin and Malignant Melanoma
| Article | Year |
|---|---|
Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study.
Topics: Adult; Clinical Trials, Phase III as Topic; Humans; Melanoma; Melatonin; Randomized Controlled Trial | 2023 |
Serum melatonin levels in melanoma patients after repeated oral administration.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Circadian Rhythm; Female; Humans; | 1994 |
A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Colorec | 1994 |
Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Stu | 1996 |
49 other studies available for melatonin and Malignant Melanoma
| Article | Year |
|---|---|
Melanogenesis Is Directly Affected by Metabolites of Melatonin in Human Melanoma Cells.
Topics: 5-Methoxytryptamine; Humans; Melanins; Melanoma; Melatonin; Monophenol Monooxygenase; Receptor, Mela | 2023 |
Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT-1 melanoma cells.
Topics: Cell Line, Tumor; Cell Survival; Humans; Melanins; Melanoma; Melatonin; Pigmentation Disorders | 2019 |
Anti-genotoxic and anti-mutagenic effects of melatonin supplementation in a mouse model of melanoma.
Topics: Animals; Antimutagenic Agents; Comet Assay; Dietary Supplements; DNA Damage; Male; Melanoma; Melaton | 2022 |
The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice.
Topics: Animals; Animals, Newborn; Female; Gene Expression Regulation; Hypothalamus; Kisspeptins; Melanoma; | 2020 |
Can melatonin and its metabolites boost the efficacy of targeted therapy in patients with advanced melanoma?
Topics: Antineoplastic Agents; Drug Therapy, Combination; Humans; Melanoma; Melatonin; Mitogen-Activated Pro | 2020 |
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells.
Topics: Antineoplastic Agents; Biotransformation; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; H | 2021 |
Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Humans; Melanoma; Melatonin; Metformin; | 2021 |
Melanin pigmentation and melanoma.
Topics: DNA Damage; Humans; Melanins; Melanocytes; Melanoma; Melatonin; Neoplasm Metastasis; Oxidants; Pigme | 2017 |
Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apopto | 2019 |
Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Fema | 2019 |
Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.
Topics: 5-Methoxytryptamine; Animals; Cell Differentiation; Cell Line; Cell Line, Tumor; Cells, Cultured; Ch | 2013 |
Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenas | 2014 |
Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro.
Topics: 5-Methoxytryptamine; Adult; Age Factors; Aged; Aged, 80 and over; Black or African American; Cell Pr | 2015 |
N1-Acetyl-5-Methoxykynuramine (AMK) is produced in the human epidermis and shows antiproliferative effects.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Black or African American; Cell Line; Cell Line, Tumor; | 2015 |
Regular sun exposure benefits health.
Topics: Animals; Circadian Rhythm; Environmental Exposure; Europe; Female; Health; Humans; Male; Melanoma; M | 2016 |
Are some melanomas caused by artificial light?
Topics: Global Health; Humans; Incidence; Lighting; Melanoma; Melatonin; Risk Factors; Skin Neoplasms | 2010 |
Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells.
Topics: Cell Line, Tumor; Cell Proliferation; Diterpenes; Humans; Melanoma; Melatonin; p38 Mitogen-Activated | 2010 |
Rotating night shifts and risk of skin cancer in the nurses' health study.
Topics: Adult; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Confounding Factors, Epidemiologic; Female; | 2011 |
Melatonin biological activity and binding sites in human melanoma cells.
Topics: Binding Sites; Binding, Competitive; Cell Division; Humans; Iodine Radioisotopes; Melanoma; Melatoni | 2003 |
Serum melatonin levels following enucleation and transpupillary thermotherapy in patients with choroidal melanoma.
Topics: Adult; Aged; Choroid Neoplasms; Enzyme-Linked Immunosorbent Assay; Eye Enucleation; Humans; Hyperthe | 2003 |
MT-1 melatonin receptor expression increases the antiproliferative effect of melatonin on S-91 murine melanoma cells.
Topics: Animals; Antineoplastic Agents; Binding Sites; Catalase; Cell Division; Colforsin; Cyclic AMP; Dose- | 2004 |
Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines.
Topics: Cell Nucleus; Cell Proliferation; Culture Media, Serum-Free; Cytosol; Free Radical Scavengers; Gene | 2006 |
[Functional characteristics of the endocrine glands in skin melanoma patients].
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Female; Humans; Hydrocortisone; Male; Melanocyte | 1984 |
Clonal heterogeneity in physiological properties of melanized cells induced from goldfish erythrophoroma cell lines.
Topics: Animals; Cell Differentiation; Cell Line; Clone Cells; Cyprinidae; Epinephrine; Goldfish; Melanocyte | 1984 |
Modulation of clonogenic human melanoma cells by follicle-stimulating hormone, melatonin, and nerve growth factor.
Topics: Clone Cells; Follicle Stimulating Hormone; Humans; Melanoma; Melatonin; Nerve Growth Factors | 1981 |
Photoperiodic control of melanoma growth in hamsters: influence of pinealectomy and melatonin.
Topics: Adrenal Glands; Androgens; Animals; Cell Division; Cricetinae; Darkness; Epididymis; Light; Luteiniz | 1983 |
Indoleamines and the UV-light-sensitive photoperiodic responses of the melanocyte network: a biological calendar?
Topics: Biopsy; Circadian Rhythm; Humans; Immunohistochemistry; Keratosis, Seborrheic; Melanocytes; Melanoma | 1994 |
Melatonin interactions with cultured murine B16 melanoma cells.
Topics: Animals; Biological Transport; Cell Division; Estradiol; Humans; Melanoma; Melanoma, Experimental; M | 1993 |
Sample size determination for an exponential survival model with an unrestricted covariate.
Topics: Computer Simulation; Factor Analysis, Statistical; Humans; Mathematical Computing; Melanoma; Melaton | 1994 |
[The role of melatonin in growth of malignant choroid melanoma].
Topics: Aqueous Humor; Cell Division; Choroid Neoplasms; Enzyme-Linked Immunosorbent Assay; Eye Enucleation; | 1993 |
Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin.
Topics: Adenylyl Cyclase Inhibitors; Cell Division; Cell Membrane; Colforsin; Cyclic AMP; DNA, Neoplasm; Hum | 1993 |
Melatonin inhibits growth of cultured human uveal melanoma cells.
Topics: Bromodeoxyuridine; Cell Division; Humans; Liver Neoplasms; Melanoma; Melatonin; Tumor Cells, Culture | 1997 |
Comparative biological activities of alpha-MSH antagonists in vertebrate pigment cells.
Topics: alpha-MSH; Amino Acid Sequence; Animals; Bufonidae; Cell Division; Fishes; Lizards; Melanocytes; Mel | 1997 |
Induced melanin reduces mutations and cell killing in mouse melanoma.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; DNA Damage; Melanoma; Melatonin; Mice; Mutation; Tu | 1997 |
A role for NAD+ and cADP-ribose in melatonin signal transduction.
Topics: Adenosine Diphosphate Ribose; Cyclic ADP-Ribose; Humans; Melanoma; Melatonin; NAD; Signal Transducti | 1998 |
Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells.
Topics: Cell Division; Dose-Response Relationship, Drug; Humans; Kynurenine; Melanoma; Melatonin; Serotonin; | 1998 |
Melatonin receptors in human uveal melanocytes and melanoma cells.
Topics: Acetamides; Blotting, Southern; Choroid Neoplasms; Dose-Response Relationship, Drug; Gene Expression | 2000 |
Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.
Topics: Acetylserotonin O-Methyltransferase; Chromatography, High Pressure Liquid; Humans; Melanoma; Melaton | 2002 |
Serotoninergic and melatoninergic systems are fully expressed in human skin.
Topics: Acetylserotonin O-Methyltransferase; Arylamine N-Acetyltransferase; Cell Line; Gene Expression; Gene | 2002 |
The influence of pineal ablation and administration of melatonin on growth and spread of hamster melanoma.
Topics: Animals; Cricetinae; Male; Melanoma; Melatonin; Neoplasms, Experimental; Pineal Gland; Time Factors | 1976 |
Melatonin and immunity.
Topics: Animals; Cell Count; Cells, Cultured; Humans; Immunity, Innate; Killer Cells, Natural; Lymphocyte Su | 1990 |
Possible association between breast cancer and malignant melanoma.
Topics: Adrenergic beta-Antagonists; Breast Neoplasms; Female; Humans; Melanoma; Melatonin; Pineal Gland; Ri | 1988 |
[HPLC detection of pathologic metabolites of melanin and melatonin metabolism in the urine in malignant melanoma of the choroid].
Topics: Choroid Neoplasms; Chromatography, High Pressure Liquid; Humans; Melanins; Melanoma; Melatonin | 1986 |
Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma.
Topics: Adrenal Cortex; Adult; Age Factors; Female; Humans; Hydrocortisone; Male; Melanoma; Melatonin; Menst | 1986 |
Effect of melatonin on B16 melanoma growth in athymic mice.
Topics: Adrenal Glands; Animals; Female; Gonads; Male; Melanoma; Melatonin; Mice; Mice, Inbred BALB C; Mice, | 1985 |
Cutaneous melanoma in miniature swine.
Topics: Animals; Animals, Newborn; Melanoma; Melatonin; Skin Neoplasms; Swine; Swine Diseases | 1968 |
The influence of certain hormones and chemicals on mammalian pigment cells.
Topics: Adrenocorticotropic Hormone; Animals; Ascorbic Acid; Chromatophores; Colchicine; Copper; Culture Tec | 1966 |
Reversal by melatonin of the effect of pinealectomy on tumor growth.
Topics: Animals; Cricetinae; Male; Melanoma; Melatonin; Neoplasm Transplantation; Neoplasms, Experimental; P | 1973 |
Effect of melatonin on hamster melanoma.
Topics: Animals; Cricetinae; Ethanol; Male; Melanoma; Melatonin; Neoplasm Transplantation; Pineal Gland; Ski | 1973 |