melatonin has been researched along with Liver Failure, Acute in 9 studies
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Accordingly, this work indicates that mPEG-b-PPS-NPs show potential as an ROS-mediated on-demand drug delivery system for improving Mel bioavailability and treating oxidative stress-associated diseases such as sepsis-induced acute liver injury." | 1.46 | Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice. ( Chen, G; Deng, H; Dong, A; Lu, M; Song, X; Xia, S; You, G; Zhang, Y; Zhao, J; Zhao, L; Zhou, H, 2017) |
| "Melatonin treatment also resulted in decreased immunoreactivity for RHDV viral VP60 antigen and a significantly reduction in RHDV VP60 mRNA levels, oxidized to reduced glutathione ratio (GSSG/GSH), caspase-3 activity, and immunoglobulin-heavy-chain-binding protein (BiP) and CCAAT/enhancer-binding protein homologous protein (CHOP) expression." | 1.40 | Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus. ( Álvarez, M; Crespo, I; González-Gallego, J; Prieto, J; San-Miguel, B; Tuñón, MJ; Vallejo, D, 2014) |
| "Melatonin treatment also resulted in reduced expression of phosphorylated Janus kinase and enhanced expression of extracellular mitogen-activated protein kinase (ERK) and signal transducer and activator of transcription (STAT) 3." | 1.38 | Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin. ( Alvarez, M; Crespo, I; González-Gallego, J; Laliena, A; San Miguel, B; Tuñón, MJ, 2012) |
| "Melatonin treatment also resulted in a reduction in caspase-8 activity, tumor necrosis factor receptor-1 (TNF-R1) expression, and phosphorylated Janus kinase (JNK) expression, and increased expression of cellular FLICE-inhibitory protein (c-FLIP)." | 1.37 | Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus. ( Alvarez, M; Crespo, I; González-Gallego, J; Jorquera, F; Prieto, J; San Miguel, B; Santamaría, E; Tuñón, MJ, 2011) |
| "Melatonin treatment was not accompanied by changes in protein levels of Kelch-like ECH-associating protein 1 (Keap1) but resulted in an increased protein expression of Nrf2 in the cytoplasm and the nucleus, which was confirmed by the results of Nrf2 immunostaining." | 1.36 | Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin. ( Alvarez, M; Crespo, I; Culebras, JM; González-Gallego, J; Laliena, A; Miguel, BS; Tuñón, MJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Crespo, I | 7 |
| Fernández-Palanca, P | 1 |
| San-Miguel, B | 4 |
| Álvarez, M | 7 |
| González-Gallego, J | 7 |
| Tuñón, MJ | 7 |
| Chen, G | 1 |
| Deng, H | 1 |
| Song, X | 1 |
| Lu, M | 1 |
| Zhao, L | 1 |
| Xia, S | 1 |
| You, G | 1 |
| Zhao, J | 1 |
| Zhang, Y | 1 |
| Dong, A | 1 |
| Zhou, H | 1 |
| Laliena, A | 3 |
| Vallejo, D | 2 |
| Prieto, J | 3 |
| Sánchez, DI | 1 |
| González-Fernández, B | 1 |
| Miguel, BS | 1 |
| Culebras, JM | 1 |
| San Miguel, B | 2 |
| Jorquera, F | 1 |
| Santamaría, E | 1 |
| Liang, YL | 1 |
| Zhang, ZH | 1 |
| Liu, XJ | 1 |
| Liu, XQ | 1 |
| Tao, L | 1 |
| Zhang, YF | 1 |
| Wang, H | 1 |
| Zhang, C | 1 |
| Chen, X | 1 |
| Xu, DX | 1 |
9 other studies available for melatonin and Liver Failure, Acute
| Article | Year |
|---|---|
Melatonin modulates mitophagy, innate immunity and circadian clocks in a model of viral-induced fulminant hepatic failure.
Topics: Animals; Biomarkers; Capsid Proteins; Circadian Clocks; Disease Models, Animal; Hemorrhagic Disease | 2020 |
Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice.
Topics: Animals; Antioxidants; Delayed-Action Preparations; Liver Failure, Acute; Male; Melatonin; Mice; Mic | 2017 |
Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin.
Topics: Animals; Antioxidants; Apoptosis; Caliciviridae Infections; Disease Models, Animal; Endoplasmic Reti | 2013 |
Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus.
Topics: Animals; Autophagy; Caliciviridae Infections; Disease Models, Animal; Hemorrhagic Disease Virus, Rab | 2014 |
Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin.
Topics: Animals; Caliciviridae Infections; Hemorrhagic Disease Virus, Rabbit; Hepatitis, Viral, Animal; Live | 2016 |
Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin.
Topics: Analysis of Variance; Animals; Antioxidants; Blotting, Western; Cell Nucleus; Cytosol; Glutathione P | 2010 |
Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus.
Topics: Animals; Apoptosis; Blotting, Western; Caspases; Hemorrhagic Disease Virus, Rabbit; Immunohistochemi | 2011 |
Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin.
Topics: Animals; Caliciviridae Infections; Hemorrhagic Disease Virus, Rabbit; HMGB1 Protein; Interleukin-1be | 2012 |
Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis Inducing Factor; Cell Death; Cytochrome P-450 CYP2E1 | 2012 |