Page last updated: 2024-10-19

melatonin and Liver Cirrhosis

melatonin has been researched along with Liver Cirrhosis in 58 studies

Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Research Excerpts

ExcerptRelevanceReference
" In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver."8.31Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023)
"To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL)."7.91Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome. ( Bosco, AD; Colares, JR; Dias, AS; Forgiarini Junior, LA; Hartmann, RM; Marroni, NP; Schedler, FB; Schemitt, EG, 2019)
"Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury."7.85Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017)
"This investigation was designed to assess the effects of oral administration of melatonin (10 mg) and tryptophan (Trp) (500 mg) on fasting and postprandial plasma levels of melatonin, gastrin, ghrelin, leptin and insulin in 10 healthy controls and in age-matched patients with liver cirrhosis (LC) and portal hypertension."7.75Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan. ( Bielanski, W; Celinski, K; Cichoz-Lach, H; Gonciarz, M; Konturek, PC; Konturek, SJ; Reiter, RJ; Slomka, M, 2009)
"A marked alteration of plasma melatonin rhythm is found in cirrhotic patients with subclinical hepatic encephalopathy."7.69[Changes in the 24-hour rhythm of plasma melatonin in patients with liver cirrhosis--relation to sleep architecture]. ( Bendok, B; Blei, AT; Finn, B; Rothke, S; Steindl, PE; Zee, PC, 1997)
"To evaluate the influence of changes in liver function on serum levels of melatonin, we measured serum levels and MCR of the hormone in patients with liver cirrhosis and in healthy control subjects."7.66Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis. ( Ibayashi, H; Iguchi, H; Kato, KI, 1982)
"Fibrosis is a common occurrence following organ injury and failure."6.53Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016)
"Sarcopenia is one of the most common features of cirrhosis, contributing to morbidity and mortality in this population."5.62Sarcopenia, oxidative stress and inflammatory process in muscle of cirrhotic rats - Action of melatonin and physical exercise. ( Colares, JR; da Fonseca, SRB; Dias, AS; Lehmann, M; Marroni, CA; Marroni, NAP; Martins, GDS; Miguel, FM; Picada, JN; Rosa, CGS, 2021)
"To assess 24-hour plasma melatonin profile as a marker of output rhythm from the circadian clock and to study sleep diaries as reflections of subjective sleep quality in patients with liver cirrhosis."5.08Disruption of the diurnal rhythm of plasma melatonin in cirrhosis. ( Bendok, B; Blei, AT; Finn, B; Rothke, S; Steindl, PE; Zee, PC, 1995)
" These have been variously attributed to hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pathophysiology remains limited and their treatment problematic."4.90Sleep-wake abnormalities in patients with cirrhosis. ( Amodio, P; Corrias, M; Costa, R; De Pittà, C; De Rui, M; Gatta, A; Merkel, C; Montagnese, S; Skene, DJ; Turco, M, 2014)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
" In a mouse NASH model with feeding of a methionine and choline-deficient (MCD) diet, MEL administration suppressed lipid accumulation and peroxidation, improved insulin sensitivity, and attenuated inflammation and fibrogenesis in the liver."4.31Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis. ( Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y, 2023)
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)."4.21 ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y, 2022)
"Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia and liver fibrosis during cholestasis-induced biliary injury via melatonin-dependent autocrine signaling through increased biliary arylalkylamine N-acetyltransferase (AANAT) expression and melatonin secretion, downregulation of miR-200b and specific circadian clock genes."3.91Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. ( Alpini, G; Ceci, L; Chen, L; Fabris, L; Francis, H; Gaudio, E; Glaser, S; Huang, Q; Invernizzi, P; Kyritsi, K; Liangpunsakul, S; Meng, F; O'Brien, A; Onori, P; Sybenga, A; Venter, J; Wu, C; Wu, N; Xie, L; Zawieja, D; Zhou, T, 2019)
"To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL)."3.91Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome. ( Bosco, AD; Colares, JR; Dias, AS; Forgiarini Junior, LA; Hartmann, RM; Marroni, NP; Schedler, FB; Schemitt, EG, 2019)
" The altered proteins are related to the development of liver pathology, such as cirrhosis (α1-antiproteinase), thrombosis (fibrinogen, plasminogen), and inflammation (mannose-binding protein A, complement C4, complement factor B), contributing to liver steatosis or hepatic cell death."3.85High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation. ( Govitrapong, P; Isarankura-Na-Ayudhya, C; Kitidee, K; Klosen, P; Pannengpetch, S; Wongchitrat, P, 2017)
"Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury."3.85Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. ( Alpini, G; DeMorrow, S; Giang, T; Glaser, S; Grant, S; Greene, JF; Jefferson, B; Kyritsi, K; McMillin, M; Meng, F; Venter, J; Wu, N; Zhou, T, 2017)
"This investigation was designed to assess the effects of oral administration of melatonin (10 mg) and tryptophan (Trp) (500 mg) on fasting and postprandial plasma levels of melatonin, gastrin, ghrelin, leptin and insulin in 10 healthy controls and in age-matched patients with liver cirrhosis (LC) and portal hypertension."3.75Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan. ( Bielanski, W; Celinski, K; Cichoz-Lach, H; Gonciarz, M; Konturek, PC; Konturek, SJ; Reiter, RJ; Slomka, M, 2009)
"To analyze pituitary hormone and melatonin circadian rhythms, and to correlate hormonal alterations with clinical performance, hepatic disease severity and diagnostic tests used for the detection of hepatic encephalopathy in cirrhosis."3.74Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy. ( Kalogeropoulos, A; Karanikolas, M; Labropoulou-Karatza, C; Polychronopoulos, P; Solomou, E; Thomopoulos, K; Velissaris, D, 2008)
"A marked alteration of plasma melatonin rhythm is found in cirrhotic patients with subclinical hepatic encephalopathy."3.69[Changes in the 24-hour rhythm of plasma melatonin in patients with liver cirrhosis--relation to sleep architecture]. ( Bendok, B; Blei, AT; Finn, B; Rothke, S; Steindl, PE; Zee, PC, 1997)
"To evaluate the influence of changes in liver function on serum levels of melatonin, we measured serum levels and MCR of the hormone in patients with liver cirrhosis and in healthy control subjects."3.66Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis. ( Ibayashi, H; Iguchi, H; Kato, KI, 1982)
"Fibrosis is a common occurrence following organ injury and failure."2.53Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016)
"Liver fibrosis is a chronic progressive disease, its resolution still unclear, and the current study explored the role of melatonin in modulation of interleukin-6 (IL-6), interleukin-4 (IL-4), transforming growth factor beta1 (TGF-β1) and urokinase plasminogen activator receptor-associated protein/Endo180 (uPARAP/Endo180) pathway in thioacetamide (TAA)-induced hepatotoxicity."1.72Melatonin attenuates thioacetamide-induced liver fibrosis in male rats through modulation of interleukin-6, interleukin-4, apoptosis and urokinase plasminogen activator receptor-associated protein/Endo180. ( Al-Khater, KM; Alasmari, WA; Alghamdi, MA; Almohawes, ZN; El Nashar, EM; El-Kott, AF; Eladl, AE; Elalfy, MM; Elhadidy, MG; Elmasry, AI; Hamed, EM; Rabei, MR; Shati, AA, 2022)
"Melatonin reduces biliary damage and liver fibrosis in cholestatic models by interaction with melatonin receptors 1A (MT1) and 1B (MT2)."1.72Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury. ( Alpini, G; Baiocchi, L; Carpino, G; Ceci, L; Chen, L; Ekser, B; Franchitto, A; Francis, H; Gaudio, E; Glaser, S; Kennedy, L; Kyritsi, K; Mancinelli, R; Meadows, V; Onori, P; Sato, K; Wu, N; Zhou, T, 2022)
"Liver fibrosis is initial stage of any chronic liver disease and its end stage is develops into cirrhosis."1.72Therapeutic potential of stem cell and melatonin on the reduction of CCl4-induced liver fibrosis in experimental mice model. ( Afridi, SG; Ayaz, M; Iqbal, M; Khan, A; Khan, B; Khan, HA; Quraish, S; Rafiq, H; Shams, S; Sher, A; Siraj, F, 2022)
"Melatonin might ameliorate liver fibrosis by regulating autophagy, suggesting that melatonin is a potential therapeutic agent for liver fibrosis."1.72Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy. ( Chen, W; Hong, RT; Jie, L; Ren, XF; Sha, LL; Zhang, YJ, 2022)
"Sarcopenia is one of the most common features of cirrhosis, contributing to morbidity and mortality in this population."1.62Sarcopenia, oxidative stress and inflammatory process in muscle of cirrhotic rats - Action of melatonin and physical exercise. ( Colares, JR; da Fonseca, SRB; Dias, AS; Lehmann, M; Marroni, CA; Marroni, NAP; Martins, GDS; Miguel, FM; Picada, JN; Rosa, CGS, 2021)
"Melatonin is an endogenously-produced molecule that functions as a copper chelator, a potent antioxidant, and as a suppressor of endoplasmic reticulum stress and the unfolded protein response in both the liver and the brain, while also reducing fibrosis/cirrhosis in the liver."1.51Melatonin: A hypothesis regarding its use to treat Wilson disease. ( Ma, Q; Reiter, RJ; Sharma, R, 2019)
"Here, we use this strategy in the liver fibrosis induced by CCl4."1.46Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4. ( Hosseini, A; Kashani, IR; Khanlarkhani, N; Majidpoor, J; Mortezaee, K; Nekoonam, S; Pasbakhsh, P; Sabbaghziarani, F; Zendedel, A, 2017)
"Liver fibrosis leads to liver cirrhosis and failure, and no effective treatment is currently available."1.43Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. ( Hong, JM; Kang, JW; Lee, SM, 2016)
"Melatonin was given at 5 or 10 mg/kg/d intraperitoneally, beginning 2 weeks after the start of CCl4 administration."1.42Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice. ( Crespo, I; Fernández, A; González-Gallego, J; Ortiz de Urbina, J; San-Miguel, B; Tuñón, MJ, 2015)
"Our findings suggest MLT may prevent liver fibrosis by inhibiting necroptosis-associated inflammatory signaling."1.42Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis. ( Choi, HS; Kang, JW; Lee, SM, 2015)
"Melatonin was given at 5 or 10 mg/kg/day i."1.42Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis. ( Crespo, I; González-Fernández, B; González-Gallego, J; Ortiz de Urbina, JJ; San-Miguel, B; Sánchez, DI; Tuñón, MJ, 2015)
"Liver fibrosis is scar tissue resulting from an uncontrolled wound-healing process in response to chronic liver injury."1.42Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase. ( Faber, KN; Heegsma, J; Laliena, A; Moshage, H; Shajari, S; Tuñón, MJ, 2015)
"Melatonin is a powerful physiologic scavenger of hydroxyl radicals."1.36Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats. ( Akin, H; Aydogan, F; Ramadan, SS; Tahan, G; Tahan, V; Tarcin, O; Uzun, H; Yapicier, O; Zengin, K, 2010)
"At present, no effective treatment of liver fibrosis is available for clinical use."1.32Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats. ( Aydin, S; Aytekin, H; Canbakan, B; Mert, A; Ozaras, R; Ozbay, G; Senturk, H; Tahan, V; Uzun, H; Yildirim, B, 2004)
" A high hepatic extraction ratio was calculated, suggesting prominent first pass hepatic metabolism and reduced bioavailability for orally administered melatonin."1.27Pharmacokinetics of melatonin in man: first pass hepatic metabolism. ( Lane, EA; Moss, HB, 1985)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19903 (5.17)18.7374
1990's4 (6.90)18.2507
2000's6 (10.34)29.6817
2010's31 (53.45)24.3611
2020's14 (24.14)2.80

Authors

AuthorsStudies
Wu, N5
Carpino, G2
Ceci, L3
Baiocchi, L2
Francis, H4
Kennedy, L3
Zhou, T5
Chen, L4
Sato, K1
Kyritsi, K4
Meadows, V1
Ekser, B2
Franchitto, A3
Mancinelli, R3
Onori, P4
Gaudio, E4
Glaser, S6
Alpini, G6
Rafiq, H1
Ayaz, M1
Khan, HA1
Iqbal, M1
Quraish, S1
Afridi, SG1
Khan, A1
Khan, B1
Sher, A1
Siraj, F1
Shams, S1
San-Miguel, B4
Fernández-Palanca, P1
Mauriz, JL1
Tuñón, MJ5
González-Gallego, J4
Jie, L1
Hong, RT2
Zhang, YJ1
Sha, LL1
Chen, W1
Ren, XF1
Owen, T1
Kundu, D1
Sybenga, A2
Isidan, A1
Xu, L1
Li, H3
Zhang, O1
Zhang, F1
Song, M1
Ma, M1
Zhao, Y3
Ding, R1
Li, D1
Dong, Z1
Jin, S2
Han, W1
Ding, C1
Chowdhury, O1
Ghosh, S1
Das, A1
Liu, H2
Shang, P1
Stepicheva, NA1
Hose, S1
Sinha, D1
Chattopadhyay, S1
Elhadidy, MG1
Elmasry, AI1
El Nashar, EM1
Alghamdi, MA1
Al-Khater, KM1
Alasmari, WA1
Eladl, AE1
Hamed, EM1
Almohawes, ZN1
El-Kott, AF1
Shati, AA1
Rabei, MR1
Elalfy, MM1
Zhu, L2
Zhang, Q2
Hua, C1
Ci, X1
Hu, C1
Zhao, L1
Tao, J1
Li, L2
Sharma, R1
Reiter, RJ5
Ma, Q1
Nese, M1
Riboli, G1
Brighetti, G1
Sassi, V1
Camela, E1
Caselli, G1
Sassaroli, S1
Borlimi, R1
Aucoin, M1
Cooley, K1
Saunders, PR1
Carè, J1
Anheyer, D1
Medina, DN1
Cardozo, V1
Remy, D1
Hannan, N1
Garber, A1
Velayos, M1
Muñoz-Serrano, AJ1
Estefanía-Fernández, K1
Sarmiento Caldas, MC1
Moratilla Lapeña, L1
López-Santamaría, M1
López-Gutiérrez, JC1
Li, J1
Zhang, J2
Shen, S1
Zhang, B2
Yu, WW1
Toyoda, H1
Huang, DQ1
Le, MH1
Nguyen, MH1
Huang, R1
Wang, J7
Xue, L1
Liu, L2
Yan, X3
Huang, S1
Li, Y7
Xu, T1
Li, C3
Ji, F1
Ming, F1
Cheng, J1
Wang, Y4
Zhao, H1
Hong, S1
Chen, K2
Zhao, XA1
Zou, L1
Sang, D1
Shao, H1
Guan, X1
Chen, X2
Chen, Y4
Wei, J1
Zhu, C1
Wu, C2
Moore, HB1
Barrett, CD1
Moore, EE1
Jhunjhunwala, R1
McIntyre, RC1
Moore, PK1
Hajizadeh, N1
Talmor, DS1
Sauaia, A1
Yaffe, MB1
Liu, C4
Lin, Y1
Dong, Y1
Wu, Y1
Bao, Y1
Yan, H2
Ma, J1
Fernández-Cuadros, ME1
Albaladejo-Florín, MJ1
Álava-Rabasa, S1
Usandizaga-Elio, I1
Martinez-Quintanilla Jimenez, D1
Peña-Lora, D1
Neira-Borrajo, I1
López-Muñoz, MJ1
Rodríguez-de-Cía, J1
Pérez-Moro, OS1
Abdallah, M1
Alsaleh, H1
Baradwan, A1
Alfawares, R1
Alobaid, A1
Rasheed, A1
Soliman, I1
Wendel Garcia, PD1
Fumeaux, T1
Guerci, P1
Heuberger, DM1
Montomoli, J2
Roche-Campo, F1
Schuepbach, RA1
Hilty, MP1
Poloni, TE1
Carlos, AF1
Cairati, M1
Cutaia, C1
Medici, V1
Marelli, E1
Ferrari, D1
Galli, A1
Bognetti, P1
Davin, A1
Cirrincione, A1
Ceretti, A1
Cereda, C1
Ceroni, M1
Tronconi, L1
Vitali, S1
Guaita, A1
Leeds, JS1
Raviprakash, V1
Jacques, T1
Scanlon, N1
Cundall, J1
Leeds, CM1
Riva, A1
Gray, EH1
Azarian, S1
Zamalloa, A1
McPhail, MJW1
Vincent, RP1
Williams, R1
Chokshi, S1
Patel, VC1
Edwards, LA1
Alqarawi, W1
Birnie, DH1
Golian, M1
Nair, GM1
Nery, PB1
Klein, A1
Davis, DR1
Sadek, MM1
Neilipovitz, D1
Johnson, CB1
Green, MS1
Redpath, C1
Miller, DC1
Beamer, P1
Billheimer, D1
Subbian, V1
Sorooshian, A1
Campbell, BS1
Mosier, JM1
Novaretti, JV1
Astur, DC1
Cavalcante, ELB1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Huang, W1
Li, T1
Ling, Y1
Qian, ZP1
Zhang, YY1
Huang, D1
Xu, SB1
Liu, XH1
Xia, L1
Yang, Y4
Lu, SH1
Lu, HZ1
Zhang, R2
Ma, JX1
Tang, S1
Li, CM1
Wan, J1
Wang, JF1
Ma, JQ1
Luo, JJ1
Chen, HY2
Mi, SL1
Chen, SY1
Su, YG1
Ge, JB1
Milheiro, SA1
Gonçalves, J1
Lopes, RMRM1
Madureira, M1
Lobo, L1
Lopes, A1
Nogueira, F1
Fontinha, D1
Prudêncio, M1
M Piedade, MF1
Pinto, SN1
Florindo, PR1
Moreira, R1
Castillo-Lora, J1
Delley, MF1
Laga, SM1
Mayer, JM1
Sutjarit, N1
Thongon, N1
Weerachayaphorn, J1
Piyachaturawat, P1
Suksamrarn, A1
Suksen, K1
Papachristou, DJ1
Blair, HC1
Hu, Y1
Shen, P1
Zeng, N1
Wang, L3
Yan, D1
Cui, L1
Yang, K2
Zhai, C1
Yang, M1
Lao, X1
Sun, J2
Ma, N1
Wang, S1
Ye, W1
Guo, P1
Rahimi, S1
Singh, MP1
Gupta, J1
Nakanishi, I1
Ohkubo, K1
Shoji, Y1
Fujitaka, Y1
Shimoda, K1
Matsumoto, KI1
Fukuhara, K1
Hamada, H1
van der Boom, T1
Gruppen, EG1
Lefrandt, JD1
Connelly, MA1
Links, TP1
Dullaart, RPF1
Berry, JD1
Bedlack, R1
Mathews, D1
Agnese, W1
Apple, S1
Meloncelli, S1
Divizia, M1
Germani, G1
Adefegha, SA1
Bottari, NB1
Leal, DB1
de Andrade, CM1
Schetinger, MR1
Martínez-Velasco, A1
Perez-Ortiz, AC1
Antonio-Aguirre, B1
Martínez-Villaseñor, L1
Lira-Romero, E1
Palacio-Pastrana, C1
Zenteno, JC1
Ramirez, I1
Zepeda-Palacio, C1
Mendoza-Velásquez, C1
Camacho-Ordóñez, A1
Ortiz Bibriesca, DM1
Estrada-Mena, FJ1
Martin, BL1
Thompson, LC1
Kim, YH2
Snow, SJ1
Schladweiler, MC1
Phillips, P1
Harmon, M1
King, C1
Richards, J1
George, I1
Haykal-Coates, N1
Gilmour, MI1
Kodavanti, UP1
Hazari, MS1
Farraj, AK1
Shen, Z1
Zou, Y1
Gao, K1
Lazar, S1
Wurtzel, JGT1
Ma, P1
Goldfinger, LE1
Vukelic, M1
Laloo, A1
Kyttaris, VC1
Chen, R1
Chen, J2
Xun, J1
Hu, Z1
Huang, Q3
Steinhart, C1
Shen, Y1
Lu, H1
Mansuri, A1
Lokhande, K1
Kore, S1
Gaikwad, S1
Nawani, N1
Swamy, KV1
Junnarkar, M1
Pawar, S1
Shaheen, MY1
Basudan, AM1
Niazy, AA1
van den Beucken, JJJP1
Jansen, JA1
Alghamdi, HS1
Gao, Q2
Guo, X1
Cao, Y1
Jia, X1
Xu, S1
Lu, C2
Zhu, H2
Melku, M1
Abebe, G1
Teketel, A1
Asrie, F1
Yalew, A1
Biadgo, B1
Kassa, E1
Damtie, D1
Anlay, DZ1
Ahmed, MFE1
Ramadan, H1
Seinige, D1
Kehrenberg, C1
Abd El-Wahab, A1
Volkmann, N1
Kemper, N1
Schulz, J1
Hu, MY1
Wu, YN1
McEvoy, MP1
Wang, YF1
Cong, WL1
Liu, LP1
Li, XX1
Zhou, CL1
Chen, WM1
Wei, KL1
Tung, SY1
Shen, CH1
Chang, TS1
Yen, CW1
Hsieh, YY1
Chiu, WN1
Hu, JH1
Lu, SN1
Hung, CH1
Alakavuklar, MA1
Fuqua, C1
Luo, KL1
Underwood, RS1
Greenwald, I1
Elashiry, MM1
Elashiry, M1
Zeitoun, R1
Elsayed, R1
Tian, F1
Saber, SE1
Elashry, SH1
Tay, FR1
Cutler, CW1
O'Dowd, A1
Maciel, M1
Poole, ST1
Jobling, MG1
Rollenhagen, JE1
Woods, CM1
Sincock, SA1
McVeigh, AL1
Gregory, MJ1
Maves, RC1
Prouty, MG1
Holmes, RK1
Savarino, SJ1
Mor, MK1
Palevsky, PM1
Kaufman, JS1
Thiessen Philbrook, H1
Weisbord, SD1
Parikh, CR1
John, CM1
Phillips, NJ1
Jarvis, GA1
Zhu, Y1
Kilburn, S1
Kapoor, M1
Chaturvedi, S1
Shaw, KJ1
Chaturvedi, V1
Kong, X1
Zhang, T1
Xiao, H1
Feng, X1
Tu, H1
Feng, J1
Sabet, M1
Tarazi, Z1
Griffith, DC1
Nguyen, F1
Guan, P1
Guerrero, DT1
Kolla, V1
Naraparaju, K1
Perry, LM1
Soberman, D1
Pressly, BB1
Alferiev, IS1
Chorny, M1
Brodeur, GM1
Gao, X2
Cheng, YH1
Enten, GA1
DeSantis, AJ1
Gaponenko, V1
Majetschak, M1
Kim, DY1
Choi, MJ1
Ko, TK1
Lee, NH1
Kim, OH1
Cheon, HG1
Cai, H1
Yip, V1
Lee, MV1
Wong, S1
Saad, O1
Ma, S1
Ljumanovic, N1
Khojasteh, SC1
Kamath, AV1
Shen, BQ1
Cuypers, ML1
Chanteux, H1
Gillent, E1
Bonnaillie, P1
Saunders, K1
Beckers, C1
Delatour, C1
Dell'Aiera, S1
Ungell, AL1
Nicolaï, J1
Knapp, AK1
Chen, A1
Griffin-Nolan, RJ1
Baur, LE1
Carroll, CJW1
Gray, JE1
Hoffman, AM1
Li, X6
Post, AK1
Slette, IJ1
Collins, SL1
Luo, Y1
Smith, MD1
Temitayo, GI1
Olawande, B1
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Timothy, AT1
Kehinde, O1
Susan, LF1
Ezra, L1
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Hawthorne, WJ1
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Li, N1
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Chen, Q1
Choi, ES1
Zhao, X3
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Sharma, S2
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Xie, C1
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Tan, ZK1
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Kovacs, A1
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Mann, DL1
Liu, J2
Huang, Y1
Kong, L1
Yu, X1
Feng, B1
Liu, D1
Zhao, B1
Mendes, GC1
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Li, P1
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Zaia, AA1
Nakanjako, D1
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Elliott, A1
Zhao, G1
Sun, P1
Hao, S1
Wang, X1
Qu, G1
Xing, Y1
Xu, X1
Maierhofer, M1
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Mayr, T1
Liu, Y2
Bigliardi, AP1
Fernandes, CLF1
Pinto, EA1
Dos Santos, M1
Garcia, EM1
Baisch, PRM1
Soares, MCF1
Muccillo-Baisch, AL1
da Silva Júnior, FMR1
Yu, W1
Ju, C1
Wang, K1
Zheng, Z1
Gao, Y1
Martínez-Navarro, EM1
Cebrián-Tarancón, C1
Moratalla-López, N1
Lorenzo, C1
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Salinas, RM1
Bermúdez de Castro, JM1
Modesto-Mata, M1
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García-Campos, C1
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Martinón-Torres, M1
Hasani, M1
Wu, F2
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Atzrodt, J1
Derdau, V1
Yao, Y1
Ou, X1
Zhao, S1
Tian, B1
Jiang, Z1
Zhou, Z1
Liu, M2
Jiang, GD1
Mou, LH1
Chen, JJ1
Li, ZY1
He, SG1
Reale, E1
Fustinoni, S1
Mercadante, R1
Polledri, E1
Hopf, NB1
Grant, PC1
Levy, K1
Lattimer, TA1
Depner, RM1
Kerr, CW1
Sato, J1
Merenda, MEZ1
Uemoto, AT1
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Barion, MRL1
Carciofi, AC1
de Paula Dorigam, JC1
Ribeiro, LB1
Vasconcellos, RS1
Waller, SB1
Peter, CM1
Hoffmann, JF1
Cleff, MB1
Faria de, RO1
Zani, JL1
Martins, BA1
Sande, D1
Solares, MD1
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Slabon, A1
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Zhao, T1
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Kaupp, M1
Lin, MH2
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Wang, H3
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Feng, W1
Kang, X2
Yan, S1
Chao, M1
Mo, S1
Sun, W1
Lu, Y1
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Stevens, DM1
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Hu, CW1
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Li, LJ1
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Mayclin, SJ1
Edwards, TE1
Tanner, JJ1
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Yu, MF1
Xia, ZZ1
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Li, DH1
Liu, T1
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He, DL1
Li, XH1
Huurman, R1
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Kataja, A1
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Zhou, XQ1
Feng, L1
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Iddi-Faical, A1
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Zhao, Q1
Tong, W1
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Zhao, D1
Norbäck, D1
Li, B1
Zhao, Z1
Huang, C1
Zhang, X1
Qian, H1
Yang, X1
Sun, Y1
Sundell, J1
Deng, Q1
Kim, HJ1
Jeon, JW1
Hwang, SM1
Chu, KI1
Cha, YH1
Kwak, YD1
Choi, SD1
Aslam, M1
Kim, CG1
Zhou, J1
Yang, E1
Yang, W1
Lim, MA1
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Kluska, M1
Lin, XJ1
Liu, R1
Yi, X1
Fu, B1
Walker, MJ1
Xu, XM1
Sun, G1
Lin, CH1
Lan, NSR1
Yeap, BB1
Fegan, PG1
Green, G1
Rankin, JM1
Dwivedi, G1
Habibi, A1
Karami, S1
Varmira, K1
Hadadi, M1
Zhang, M1
Li, Q1
Lan, X1
Zheng, J1
Eskandari-Sedighi, G1
Cortez, LM1
Daude, N1
Shmeit, K1
Sim, V1
Westaway, D1
Weigand, S1
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Kantenwein, V1
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Schaarschmidt, C1
von Olshausen, G1
Reents, T1
Deisenhofer, I1
Lennerz, C1
Kolb, C1
Iwata, H1
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Seko, S1
Kawanishi, H1
Hattori, R1
Gotoh, M1
Tsuzuki, T1
Chen, D1
Chen, YP1
Zhou, M1
Waterhouse, GIN1
Shi, W1
Ai, S1
Manne, ASN1
Hegde, AR1
Raut, SY1
Rao, RR1
Kulkarni, VI1
Mutalik, S1
Jafari, R1
Hectors, SJ1
Koehne de González, AK1
Spincemaille, P1
Prince, MR1
Brittenham, GM1
Rosa, CGS1
Colares, JR2
da Fonseca, SRB1
Martins, GDS1
Miguel, FM1
Dias, AS2
Marroni, CA1
Picada, JN1
Lehmann, M1
Marroni, NAP1
Marjot, T1
Ray, DW1
Williams, FR1
Tomlinson, JW1
Armstrong, MJ1
Mortezaee, K2
Khanlarkhani, N1
Sabbaghziarani, F2
Nekoonam, S1
Majidpoor, J1
Hosseini, A1
Pasbakhsh, P2
Kashani, IR1
Zendedel, A2
Wongchitrat, P1
Klosen, P1
Pannengpetch, S1
Kitidee, K1
Govitrapong, P1
Isarankura-Na-Ayudhya, C1
Meng, F4
Han, Y1
Venter, J3
DeMorrow, S2
Invernizzi, P2
Bernuzzi, F1
Esrefoglu, M1
Cetin, A1
Taslidere, E1
Elbe, H1
Ates, B1
Tok, OE1
Aydin, MS1
McMillin, M1
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Giang, T1
Greene, JF1
Jefferson, B1
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Tohamy, HG1
El-Sayed, YS1
Zemlianitsyna, O1
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Korolczuk, A1
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Hu, W1
Ma, Z1
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Fan, C1
Deng, C1
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Hong, JM1
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Naaz, S1
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Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Association of Anesthesia Technique With Morbidity and Mortality in Patients With COVID-19 and Surgery for Hip Fracture: a Retrospective Population Cohort Study[NCT05133648]1,000 participants (Anticipated)Observational2023-01-05Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for melatonin and Liver Cirrhosis

ArticleYear
Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence.
    Journal of cellular physiology, 2022, Volume: 237, Issue:7

    Topics: Anti-Inflammatory Agents; Antioxidants; Humans; Liver Cirrhosis; Melatonin

2022
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Protective role of melatonin in early-stage and end-stage liver cirrhosis.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:11

    Topics: Animals; Antioxidants; Humans; Liver Cirrhosis; Melatonin; Protective Agents

2019
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
Sleep and liver disease: a bidirectional relationship.
    The lancet. Gastroenterology & hepatology, 2021, Volume: 6, Issue:10

    Topics: Body Temperature Regulation; Case-Control Studies; Chronic Disease; Cost of Illness; Disease Progres

2021
Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease.
    Clinics and research in hepatology and gastroenterology, 2018, Volume: 42, Issue:4

    Topics: Animals; Arginine Vasopressin; Biliary Tract; Cell Proliferation; Cholangitis; Cholestasis; Epitheli

2018
Sleep-wake abnormalities in patients with cirrhosis.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:2

    Topics: Circadian Rhythm; Hepatic Encephalopathy; Homeostasis; Humans; Liver; Liver Cirrhosis; Melatonin; Sl

2014
Melatonin: the dawning of a treatment for fibrosis?
    Journal of pineal research, 2016, Volume: 60, Issue:2

    Topics: Animals; Extracellular Matrix; Fibrosis; Heart Diseases; Humans; Kidney Diseases; Liver Cirrhosis; M

2016
[Melatonin, a clinically important hormone?].
    Deutsche medizinische Wochenschrift (1946), 1983, Mar-25, Volume: 108, Issue:12

    Topics: Animals; Brain Neoplasms; Breast Neoplasms; Central Nervous System; Circadian Rhythm; Female; Humans

1983

Trials

4 trials available for melatonin and Liver Cirrhosis

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain;

2022
The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010, Volume: 61, Issue:5

    Topics: Adult; Antioxidants; Cytokines; Fatty Liver; Female; gamma-Glutamyltransferase; Hepatocytes; Humans;

2010
Disruption of the diurnal rhythm of plasma melatonin in cirrhosis.
    Annals of internal medicine, 1995, Aug-15, Volume: 123, Issue:4

    Topics: Adult; Biomarkers; Circadian Rhythm; Female; Humans; Liver Cirrhosis; Male; Melatonin; Middle Aged;

1995

Other Studies

47 other studies available for melatonin and Liver Cirrhosis

ArticleYear
Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury.
    Hepatology (Baltimore, Md.), 2022, Volume: 75, Issue:4

    Topics: Animals; Cholestasis; Liver Cirrhosis; Melatonin; Mice; Mice, Knockout; Receptor, Melatonin, MT1; Re

2022
Therapeutic potential of stem cell and melatonin on the reduction of CCl4-induced liver fibrosis in experimental mice model.
    Brazilian journal of biology = Revista brasleira de biologia, 2022, Volume: 84

    Topics: Animals; Carbon Tetrachloride; Female; Liver Cirrhosis; Melatonin; Mesenchymal Stem Cell Transplanta

2022
Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy.
    Current medical science, 2022, Volume: 42, Issue:3

    Topics: Animals; Autophagy; Beclin-1; Disease Models, Animal; Hepatic Stellate Cells; Liver Cirrhosis; Melat

2022
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.
    Cellular and molecular gastroenterology and hepatology, 2022, Volume: 14, Issue:4

    Topics: Animals; Cholangitis, Sclerosing; Cholestasis; Disease Models, Animal; Drinking Water; Glutathione;

2022
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
    Journal of molecular endocrinology, 2023, Jan-01, Volume: 70, Issue:1

    Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis

2023
Sustained systemic inflammation increases autophagy and induces EMT/fibrotic changes in mouse liver cells: Protection by melatonin.
    Cellular signalling, 2023, Volume: 101

    Topics: Animals; Autophagy; Epithelial-Mesenchymal Transition; Hepatocytes; Inflammation; Liver; Liver Cirrh

2023
Melatonin attenuates thioacetamide-induced liver fibrosis in male rats through modulation of interleukin-6, interleukin-4, apoptosis and urokinase plasminogen activator receptor-associated protein/Endo180.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2022, Volume: 73, Issue:5

    Topics: Animals; Apoptosis; Collagen; Interleukin-4; Interleukin-6; Liver; Liver Cirrhosis; Male; Melatonin;

2022
Melatonin alleviates particulate matter-induced liver fibrosis by inhibiting ROS-mediated mitophagy and inflammation via Nrf2 activation.
    Ecotoxicology and environmental safety, 2023, Volume: 268

    Topics: Animals; Inflammation; Liver Cirrhosis; Melatonin; Mice; Mitophagy; NF-E2-Related Factor 2; Particul

2023
Melatonin: A hypothesis regarding its use to treat Wilson disease.
    Medical hypotheses, 2019, Volume: 133

    Topics: Animals; Antioxidants; Bile; Brain; Butyrates; Chelating Agents; Chelation Therapy; Copper; Copper-T

2019
    Journal of clinical orthopaedics and trauma, 2021, Volume: 12, Issue:1

    Topics: Acute Coronary Syndrome; Adolescent; Adsorption; Adult; Aged; Animals; Aspergillus; Aspergillus oryz

2021
Sarcopenia, oxidative stress and inflammatory process in muscle of cirrhotic rats - Action of melatonin and physical exercise.
    Experimental and molecular pathology, 2021, Volume: 121

    Topics: Animals; Antioxidants; Inflammation; Liver Cirrhosis; Male; Melatonin; Oxidative Stress; Physical Co

2021
Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4.
    Cell and tissue research, 2017, Volume: 369, Issue:2

    Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Hydroxyproline; Liver Cirrhosis; Male; Melatonin;

2017
High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation.
    Nutrition research (New York, N.Y.), 2017, Volume: 42

    Topics: alpha 1-Antitrypsin; Animals; Biomarkers; Blood Glucose; Blood Proteins; Body Weight; Complement C4;

2017
Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:10

    Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cholangitis, Sclerosing; Darkness; Diseas

2017
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
    Bratislavske lekarske listy, 2017, Volume: 118, Issue:6

    Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi

2017
Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2017, Nov-01, Volume: 313, Issue:5

    Topics: Animals; Bile Ducts; Cell Proliferation; Central Nervous System Depressants; Cholestasis; Disease Mo

2017
Melatonin mitigates thioacetamide-induced hepatic fibrosis via antioxidant activity and modulation of proinflammatory cytokines and fibrogenic genes.
    Life sciences, 2018, Jan-01, Volume: 192

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Hydroxyproline; Liver; Li

2018
FEATURES OF EXCRETION OF MELATONIN IN URINE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND NON-ALCOHOLIC FATTY LIVER DISEASE WITH MANIFESTATIONS OF FIBROSIS AND ITS RELATIONSHIP WITH CERTAIN METABOLIC AND IMMUNOLOGICAL INDICATORS.
    Georgian medical news, 2018, Issue:274

    Topics: Adolescent; Adult; Albuminuria; Biomarkers; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes;

2018
Application of Monte Carlo cross-validation to identify pathway cross-talk in neonatal sepsis.
    Experimental biology and medicine (Maywood, N.J.), 2018, Volume: 243, Issue:5

    Topics: Dendritic Cells; Gene Expression Profiling; Gene Regulatory Networks; Glycolysis; Humans; Immune Sys

2018
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.
    Biochimica et biophysica acta. Molecular basis of disease, 2019, 06-01, Volume: 1865, Issue:6

    Topics: Animals; Arylalkylamine N-Acetyltransferase; Bile Ducts, Intrahepatic; Cell Line; Cell Proliferation

2019
Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome.
    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 2019, May-30, Volume: 45, Issue:3

    Topics: Animals; Antioxidants; Arterial Pressure; Bile Ducts; Blood Gas Analysis; Catalase; Disease Models,

2019
Assessment of 6-sulfatoxymelatonin rhythms and melatonin response to light in disease states: lessons from cirrhosis.
    Chronobiology international, 2015, Volume: 32, Issue:2

    Topics: Adult; Aged; Circadian Rhythm; Female; Healthy Volunteers; Humans; Light; Liver Cirrhosis; Male; Mel

2015
Melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis.
    Journal of pineal research, 2015, Volume: 58, Issue:1

    Topics: Animals; Antigens, Differentiation; Antioxidants; Carbon Tetrachloride Poisoning; Cell Differentiati

2015
Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice.
    Translational research : the journal of laboratory and clinical medicine, 2015, Volume: 165, Issue:2

    Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Cytokines; Disease Progression; Gene Expression; He

2015
Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis.
    Translational research : the journal of laboratory and clinical medicine, 2015, Volume: 166, Issue:3

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Hepatocytes; HMGB1 Protein; Interleukin-1alpha; Interleuki

2015
Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis.
    Journal of pineal research, 2015, Volume: 59, Issue:2

    Topics: Animals; Autophagy; Carbon Tetrachloride Poisoning; Endoplasmic Reticulum Chaperone BiP; Endoplasmic

2015
Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase.
    Journal of pineal research, 2015, Volume: 59, Issue:3

    Topics: Animals; Antioxidants; Arachidonate 5-Lipoxygenase; Hepatic Stellate Cells; Liver Cirrhosis; Melaton

2015
Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2015, Volume: 66, Issue:4

    Topics: Animals; Aryldialkylphosphatase; Cytokines; Liver; Liver Cirrhosis; Liver Function Tests; Male; Mela

2015
Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis.
    Journal of pineal research, 2016, Volume: 60, Issue:4

    Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrho

2016
Melatonin Pretreatment Enhances the Homing of Bone Marrow-derived Mesenchymal Stem Cells Following Transplantation in a Rat Model of Liver Fibrosis.
    Iranian biomedical journal, 2016, Volume: 20, Issue:4

    Topics: Adipocytes; Adipogenesis; Animals; Antigens, CD34; Bone Marrow Cells; Carbon Tetrachloride; CD11b An

2016
Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver.
    Bulletin of experimental biology and medicine, 2016, Volume: 161, Issue:6

    Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Crosses, Genetic; Female; G

2016
Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells.
    BioFactors (Oxford, England), 2017, Volume: 43, Issue:2

    Topics: Animals; Carbon Tetrachloride; Cell Line; Gene Expression Regulation; Hepatic Stellate Cells; Humans

2017
Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice.
    Journal of pineal research, 2017, Volume: 62, Issue:4

    Topics: Animals; Antioxidants; Diet, High-Fat; Hepatic Stellate Cells; Hepatocytes; Liver; Liver Cirrhosis;

2017
Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy.
    World journal of gastroenterology, 2008, Jul-14, Volume: 14, Issue:26

    Topics: Aged; Circadian Rhythm; Electroencephalography; Female; Hepatic Encephalopathy; Humans; Hydrocortiso

2008
Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats.
    World journal of gastroenterology, 2009, Mar-28, Volume: 15, Issue:12

    Topics: Animals; Carbon Tetrachloride; Glutathione Peroxidase; Hyaluronic Acid; Hydroxyproline; Laminin; Liv

2009
Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan.
    Journal of pineal research, 2009, Volume: 46, Issue:4

    Topics: Administration, Oral; Basal Metabolism; Case-Control Studies; Data Interpretation, Statistical; Gast

2009
Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome?
    Metabolic brain disease, 2009, Volume: 24, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Chronobiology Disorders; Female; Humans; Liver Cirrhosis; Male; Mela

2009
Melatonin rhythms in patients with cirrhosis.
    The American journal of gastroenterology, 2010, Volume: 105, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Circadian Rhythm; Female; Hepatitis C, Chronic; Humans; Liver Cirrho

2010
On the origin and the consequences of circadian abnormalities in patients with cirrhosis.
    The American journal of gastroenterology, 2010, Volume: 105, Issue:8

    Topics: Actigraphy; Adult; Aged; Aged, 80 and over; Case-Control Studies; Circadian Rhythm; Female; Humans;

2010
Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats.
    Canadian journal of surgery. Journal canadien de chirurgie, 2010, Volume: 53, Issue:5

    Topics: Acridines; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransfe

2010
Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats.
    Journal of pineal research, 2004, Volume: 37, Issue:2

    Topics: Animals; Antioxidants; Dimethylnitrosamine; Glutathione; Hydroxyproline; Lipid Peroxidation; Liver C

2004
Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:5

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Cholesterol; Circadian Rhythm;

1982
Liver cirrhosis and circadian rhythm.
    Annals of internal medicine, 1996, Jul-15, Volume: 125, Issue:2

    Topics: Circadian Rhythm; Humans; Liver Cirrhosis; Melatonin; Sleep Wake Disorders

1996
Impaired hepatic catabolism of melatonin in cirrhosis.
    Annals of internal medicine, 1997, Sep-15, Volume: 127, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Circadian Rhythm; Female; Humans; Liver; Liver Cirrhosis; Melatonin;

1997
[Changes in the 24-hour rhythm of plasma melatonin in patients with liver cirrhosis--relation to sleep architecture].
    Wiener klinische Wochenschrift, 1997, Oct-03, Volume: 109, Issue:18

    Topics: Adult; Arousal; Circadian Rhythm; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Mel

1997
Cirrhosis does not shift the circadian phase of plasma fibrinolysis.
    The American journal of gastroenterology, 2002, Volume: 97, Issue:6

    Topics: Circadian Rhythm; Female; Fibrinolysis; Humans; Liver Cirrhosis; Male; Melatonin; Middle Aged; Plasm

2002
Pharmacokinetics of melatonin in man: first pass hepatic metabolism.
    The Journal of clinical endocrinology and metabolism, 1985, Volume: 61, Issue:6

    Topics: Administration, Oral; Biological Availability; Humans; Injections, Intravenous; Kinetics; Liver; Liv

1985