melatonin has been researched along with Leukemia in 17 studies
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We studied the combined effect of MEL and drugs from different pharmacological groups, such as cytarabine (CYT) and navitoclax (ABT-737), on the state of the pool of acute myeloid leukemia (AML) tumor cell using the MV4-11 cell line as model." | 8.31 | Melatonin Can Enhance the Effect of Drugs Used in the Treatment of Leukemia. ( Baburina, YL; Fadeev, RS; Kobyakova, MI; Krestinin, RR; Krestinina, OV; Lomovskaya, YV; Lomovsky, AI; Sotnikova, LD, 2023) |
| "Thus, finding new treatments for leukemia is essential." | 6.66 | Melatonin: A promising agent targeting leukemia. ( Asemi, Z; Mirzaei, H; Shafabakhsh, R, 2020) |
| "Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood." | 5.51 | Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. ( Deng, W; Huang, LB; Huang, W; Ke, ZY; Li, Y; Liang, C; Liu, XJ; Luo, JS; Luo, XQ; Peng, CJ; Qin, G; Sun, X; Tang, WY; Tang, YL; Wang, LN; Zhang, XL, 2019) |
| "Melatonin is an endogenous indoleamine with a wide range of biological functions." | 5.43 | Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells. ( Cabrera, J; Estévez, F; Loro, JF; Perdomo, J; Quintana, C; Quintana, J; Reiter, RJ, 2016) |
| "Melatonin is a naturally occurring indoleamine synthesized in the pineal gland that exhibits an extensive repertoire of biological activities." | 5.39 | Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. ( Cabrera, J; Estévez, F; Loro, J; Perdomo, J; Quintana, J; Reiter, RJ, 2013) |
| "Melatonin treatment was not associated with significant cytotoxicity in HL-60 cells, although the generation of ROS was significantly increased." | 5.33 | Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect. ( Buck, S; Büyükavci, M; Ozdemir, O; Ravindranath, Y; Savaşan, S; Stout, M, 2006) |
| "The so-called 'Melatonin Hypothesis' proposed that decreased nocturnal production of melatonin (MLT) might explain the increased risk of breast cancer that has been formerly attributed to extremely low-frequency (ELF) magnetic fields (MF) of weak intensity." | 4.88 | Health effects of extremely low-frequency magnetic fields: reconsidering the melatonin hypothesis in the light of current data on magnetoreception. ( Bouland, C; Burda, H; de Brouwer, C; Vanderstraeten, J; Verschaeve, L, 2012) |
| " We studied the combined effect of MEL and drugs from different pharmacological groups, such as cytarabine (CYT) and navitoclax (ABT-737), on the state of the pool of acute myeloid leukemia (AML) tumor cell using the MV4-11 cell line as model." | 4.31 | Melatonin Can Enhance the Effect of Drugs Used in the Treatment of Leukemia. ( Baburina, YL; Fadeev, RS; Kobyakova, MI; Krestinin, RR; Krestinina, OV; Lomovskaya, YV; Lomovsky, AI; Sotnikova, LD, 2023) |
| "Thus, finding new treatments for leukemia is essential." | 2.66 | Melatonin: A promising agent targeting leukemia. ( Asemi, Z; Mirzaei, H; Shafabakhsh, R, 2020) |
| "Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood." | 1.51 | Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. ( Deng, W; Huang, LB; Huang, W; Ke, ZY; Li, Y; Liang, C; Liu, XJ; Luo, JS; Luo, XQ; Peng, CJ; Qin, G; Sun, X; Tang, WY; Tang, YL; Wang, LN; Zhang, XL, 2019) |
| "Melatonin is an important regulator in human circadian rhythms and the sleep-wake cycle." | 1.48 | Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances. ( Brabant, G; Clusmann, H; Gebauer, J; Kreitschmann-Andermahr, I; Piroth, M; Rosenkranz, E; Siegel, S; Thissen, A, 2018) |
| "Melatonin is an endogenous indoleamine with a wide range of biological functions." | 1.43 | Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells. ( Cabrera, J; Estévez, F; Loro, JF; Perdomo, J; Quintana, C; Quintana, J; Reiter, RJ, 2016) |
| "Melatonin is an indolamine that functions in the regulation of chronobiological rhythms to exert cytotoxic effects." | 1.42 | Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase. ( Asano, T; Narazaki, H; Yamanishi, M, 2015) |
| "Melatonin is a naturally occurring indoleamine synthesized in the pineal gland that exhibits an extensive repertoire of biological activities." | 1.39 | Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. ( Cabrera, J; Estévez, F; Loro, J; Perdomo, J; Quintana, J; Reiter, RJ, 2013) |
| "Melatonin is an indolamine without relevant side effects." | 1.37 | Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients. ( Antolín, I; Casado-Zapico, S; García-Pedrero, JM; García-Santos, G; Luño, E; Martín, V; Menendez, ST; Rodriguez, C; Rodríguez-Blanco, J; Sánchez-Sánchez, AM; Suárez, C, 2011) |
| "Melatonin treatment was not associated with significant cytotoxicity in HL-60 cells, although the generation of ROS was significantly increased." | 1.33 | Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect. ( Buck, S; Büyükavci, M; Ozdemir, O; Ravindranath, Y; Savaşan, S; Stout, M, 2006) |
| "When melatonin was injected along with aracytin, it would significantly increase (P < 0." | 1.30 | Potential protective effects of melatonin on bone marrow of rats exposed to cytotoxic drugs. ( Anwar, MM; Mahfouz, HA; Sayed, AS, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Lomovsky, AI | 1 |
| Baburina, YL | 1 |
| Fadeev, RS | 1 |
| Lomovskaya, YV | 1 |
| Kobyakova, MI | 1 |
| Krestinin, RR | 1 |
| Sotnikova, LD | 1 |
| Krestinina, OV | 1 |
| Shafabakhsh, R | 1 |
| Mirzaei, H | 1 |
| Asemi, Z | 1 |
| Ng, MG | 1 |
| Ng, KY | 1 |
| Koh, RY | 1 |
| Chye, SM | 1 |
| Rosenkranz, E | 1 |
| Thissen, A | 1 |
| Siegel, S | 1 |
| Piroth, M | 1 |
| Clusmann, H | 1 |
| Gebauer, J | 1 |
| Brabant, G | 1 |
| Kreitschmann-Andermahr, I | 1 |
| Tang, YL | 1 |
| Sun, X | 1 |
| Huang, LB | 1 |
| Liu, XJ | 1 |
| Qin, G | 1 |
| Wang, LN | 1 |
| Zhang, XL | 1 |
| Ke, ZY | 1 |
| Luo, JS | 1 |
| Liang, C | 1 |
| Peng, CJ | 1 |
| Tang, WY | 1 |
| Li, Y | 1 |
| Huang, W | 1 |
| Luo, XQ | 1 |
| Deng, W | 1 |
| Zhou, B | 1 |
| Ye, H | 1 |
| Xing, C | 1 |
| Liang, B | 1 |
| Li, H | 1 |
| Chen, L | 1 |
| Huang, X | 1 |
| Wu, Y | 1 |
| Gao, S | 1 |
| Zheng, T | 1 |
| Fu, JJ | 1 |
| Hu, L | 1 |
| Qiu, F | 1 |
| Hu, M | 1 |
| Zhu, JJ | 1 |
| Hua, ZC | 1 |
| Wang, H | 1 |
| Perdomo, J | 2 |
| Cabrera, J | 2 |
| Estévez, F | 2 |
| Loro, J | 1 |
| Reiter, RJ | 2 |
| Quintana, J | 2 |
| Yamanishi, M | 1 |
| Narazaki, H | 1 |
| Asano, T | 1 |
| Quintana, C | 1 |
| Loro, JF | 1 |
| Casado-Zapico, S | 1 |
| Martín, V | 1 |
| García-Santos, G | 1 |
| Rodríguez-Blanco, J | 1 |
| Sánchez-Sánchez, AM | 1 |
| Luño, E | 1 |
| Suárez, C | 1 |
| García-Pedrero, JM | 1 |
| Menendez, ST | 1 |
| Antolín, I | 1 |
| Rodriguez, C | 1 |
| Vanderstraeten, J | 1 |
| Verschaeve, L | 1 |
| Burda, H | 1 |
| Bouland, C | 1 |
| de Brouwer, C | 1 |
| Büyükavci, M | 1 |
| Ozdemir, O | 1 |
| Buck, S | 1 |
| Stout, M | 1 |
| Ravindranath, Y | 1 |
| Savaşan, S | 1 |
| Henshaw, DL | 1 |
| Ward, JP | 1 |
| Matthews, JC | 1 |
| Anwar, MM | 1 |
| Mahfouz, HA | 1 |
| Sayed, AS | 1 |
| Smith, JA | 1 |
| Mee, TJ | 1 |
| Barnes, ND | 1 |
| Thorburn, RJ | 1 |
| Barnes, JL | 1 |
| Raĭkhlin, NT | 1 |
| Kvetnoĭ, IM | 1 |
4 reviews available for melatonin and Leukemia
| Article | Year |
|---|---|
Melatonin: A promising agent targeting leukemia.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Cell Proliferation; DNA Damage; Gene Expr | 2020 |
Potential role of melatonin in prevention and treatment of leukaemia.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Management; Humans; Leukemia; Melatonin; Outcome Ass | 2021 |
Health effects of extremely low-frequency magnetic fields: reconsidering the melatonin hypothesis in the light of current data on magnetoreception.
Topics: Animals; Breast Neoplasms; Circadian Rhythm; Environmental Exposure; Female; Humans; Leukemia; Magne | 2012 |
Can disturbances in the atmospheric electric field created by powerline corona ions disrupt melatonin production in the pineal gland?
Topics: Adult; Air Pollutants; Animals; Atmosphere; Child; Circadian Rhythm; Electromagnetic Fields; Humans; | 2008 |
13 other studies available for melatonin and Leukemia
| Article | Year |
|---|---|
Melatonin Can Enhance the Effect of Drugs Used in the Treatment of Leukemia.
Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Leukemia; Mel | 2023 |
Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances.
Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Cross-Sectional Studies; Female; Humans; Leukemia; | 2018 |
Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways.
Topics: Animals; Antigens, Nuclear; Cell Line, Tumor; Cell Proliferation; Child; Child, Preschool; Cyclooxyg | 2019 |
Targeting miR-193a-AML1-ETO-β-catenin axis by melatonin suppresses the self-renewal of leukaemia stem cells in leukaemia with t (8;21) translocation.
Topics: Animals; Apoptosis; beta Catenin; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Self Ren | 2019 |
Nanoarchitectured electrochemical cytosensors for selective detection of leukemia cells and quantitative evaluation of death receptor expression on cell surfaces.
Topics: Antioxidants; Biosensing Techniques; Carbon; Electrochemical Techniques; Electrodes; Ferric Compound | 2013 |
Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells.
Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Cell Line, Tumor; Cytochromes c; Dru | 2013 |
Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase.
Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; Clofarabine; Deoxy | 2015 |
Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells.
Topics: Apoptosis; Caspases; HL-60 Cells; Humans; Hypothermia, Induced; K562 Cells; Leukemia; Melatonin; Neo | 2016 |
Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients.
Topics: Apoptosis; Blotting, Western; Caspase 3; Fas Ligand Protein; fas Receptor; HL-60 Cells; Humans; Leuk | 2011 |
Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect.
Topics: Apoptosis; Cell Survival; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Jurkat Cells; Leuke | 2006 |
Potential protective effects of melatonin on bone marrow of rats exposed to cytotoxic drugs.
Topics: Acid Phosphatase; Adjuvants, Immunologic; Alkaline Phosphatase; Animals; Bone Marrow Cells; Cell Sur | 1998 |
Melatonin in serum and cerebrospinal fluid.
Topics: Child; Child, Preschool; Female; Humans; Leukemia; Male; Melatonin | 1976 |
[Dynamics of changes in enterochromaffin cells during tumor growth].
Topics: Chromaffin System; Enterochromaffin Cells; Gastrointestinal Neoplasms; Humans; Hyperplasia; Leukemia | 1976 |