Page last updated: 2024-10-19

melatonin and Leukemia

melatonin has been researched along with Leukemia in 17 studies

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
" We studied the combined effect of MEL and drugs from different pharmacological groups, such as cytarabine (CYT) and navitoclax (ABT-737), on the state of the pool of acute myeloid leukemia (AML) tumor cell using the MV4-11 cell line as model."8.31Melatonin Can Enhance the Effect of Drugs Used in the Treatment of Leukemia. ( Baburina, YL; Fadeev, RS; Kobyakova, MI; Krestinin, RR; Krestinina, OV; Lomovskaya, YV; Lomovsky, AI; Sotnikova, LD, 2023)
"Thus, finding new treatments for leukemia is essential."6.66Melatonin: A promising agent targeting leukemia. ( Asemi, Z; Mirzaei, H; Shafabakhsh, R, 2020)
"Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood."5.51Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. ( Deng, W; Huang, LB; Huang, W; Ke, ZY; Li, Y; Liang, C; Liu, XJ; Luo, JS; Luo, XQ; Peng, CJ; Qin, G; Sun, X; Tang, WY; Tang, YL; Wang, LN; Zhang, XL, 2019)
"Melatonin is an endogenous indoleamine with a wide range of biological functions."5.43Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells. ( Cabrera, J; Estévez, F; Loro, JF; Perdomo, J; Quintana, C; Quintana, J; Reiter, RJ, 2016)
"Melatonin is a naturally occurring indoleamine synthesized in the pineal gland that exhibits an extensive repertoire of biological activities."5.39Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. ( Cabrera, J; Estévez, F; Loro, J; Perdomo, J; Quintana, J; Reiter, RJ, 2013)
"Melatonin treatment was not associated with significant cytotoxicity in HL-60 cells, although the generation of ROS was significantly increased."5.33Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect. ( Buck, S; Büyükavci, M; Ozdemir, O; Ravindranath, Y; Savaşan, S; Stout, M, 2006)
"The so-called 'Melatonin Hypothesis' proposed that decreased nocturnal production of melatonin (MLT) might explain the increased risk of breast cancer that has been formerly attributed to extremely low-frequency (ELF) magnetic fields (MF) of weak intensity."4.88Health effects of extremely low-frequency magnetic fields: reconsidering the melatonin hypothesis in the light of current data on magnetoreception. ( Bouland, C; Burda, H; de Brouwer, C; Vanderstraeten, J; Verschaeve, L, 2012)
" We studied the combined effect of MEL and drugs from different pharmacological groups, such as cytarabine (CYT) and navitoclax (ABT-737), on the state of the pool of acute myeloid leukemia (AML) tumor cell using the MV4-11 cell line as model."4.31Melatonin Can Enhance the Effect of Drugs Used in the Treatment of Leukemia. ( Baburina, YL; Fadeev, RS; Kobyakova, MI; Krestinin, RR; Krestinina, OV; Lomovskaya, YV; Lomovsky, AI; Sotnikova, LD, 2023)
"Thus, finding new treatments for leukemia is essential."2.66Melatonin: A promising agent targeting leukemia. ( Asemi, Z; Mirzaei, H; Shafabakhsh, R, 2020)
"Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood."1.51Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways. ( Deng, W; Huang, LB; Huang, W; Ke, ZY; Li, Y; Liang, C; Liu, XJ; Luo, JS; Luo, XQ; Peng, CJ; Qin, G; Sun, X; Tang, WY; Tang, YL; Wang, LN; Zhang, XL, 2019)
"Melatonin is an important regulator in human circadian rhythms and the sleep-wake cycle."1.48Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances. ( Brabant, G; Clusmann, H; Gebauer, J; Kreitschmann-Andermahr, I; Piroth, M; Rosenkranz, E; Siegel, S; Thissen, A, 2018)
"Melatonin is an endogenous indoleamine with a wide range of biological functions."1.43Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells. ( Cabrera, J; Estévez, F; Loro, JF; Perdomo, J; Quintana, C; Quintana, J; Reiter, RJ, 2016)
"Melatonin is an indolamine that functions in the regulation of chronobiological rhythms to exert cytotoxic effects."1.42Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase. ( Asano, T; Narazaki, H; Yamanishi, M, 2015)
"Melatonin is a naturally occurring indoleamine synthesized in the pineal gland that exhibits an extensive repertoire of biological activities."1.39Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. ( Cabrera, J; Estévez, F; Loro, J; Perdomo, J; Quintana, J; Reiter, RJ, 2013)
"Melatonin is an indolamine without relevant side effects."1.37Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients. ( Antolín, I; Casado-Zapico, S; García-Pedrero, JM; García-Santos, G; Luño, E; Martín, V; Menendez, ST; Rodriguez, C; Rodríguez-Blanco, J; Sánchez-Sánchez, AM; Suárez, C, 2011)
"Melatonin treatment was not associated with significant cytotoxicity in HL-60 cells, although the generation of ROS was significantly increased."1.33Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect. ( Buck, S; Büyükavci, M; Ozdemir, O; Ravindranath, Y; Savaşan, S; Stout, M, 2006)
"When melatonin was injected along with aracytin, it would significantly increase (P < 0."1.30Potential protective effects of melatonin on bone marrow of rats exposed to cytotoxic drugs. ( Anwar, MM; Mahfouz, HA; Sayed, AS, 1998)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's1 (5.88)18.2507
2000's2 (11.76)29.6817
2010's9 (52.94)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Lomovsky, AI1
Baburina, YL1
Fadeev, RS1
Lomovskaya, YV1
Kobyakova, MI1
Krestinin, RR1
Sotnikova, LD1
Krestinina, OV1
Shafabakhsh, R1
Mirzaei, H1
Asemi, Z1
Ng, MG1
Ng, KY1
Koh, RY1
Chye, SM1
Rosenkranz, E1
Thissen, A1
Siegel, S1
Piroth, M1
Clusmann, H1
Gebauer, J1
Brabant, G1
Kreitschmann-Andermahr, I1
Tang, YL1
Sun, X1
Huang, LB1
Liu, XJ1
Qin, G1
Wang, LN1
Zhang, XL1
Ke, ZY1
Luo, JS1
Liang, C1
Peng, CJ1
Tang, WY1
Li, Y1
Huang, W1
Luo, XQ1
Deng, W1
Zhou, B1
Ye, H1
Xing, C1
Liang, B1
Li, H1
Chen, L1
Huang, X1
Wu, Y1
Gao, S1
Zheng, T1
Fu, JJ1
Hu, L1
Qiu, F1
Hu, M1
Zhu, JJ1
Hua, ZC1
Wang, H1
Perdomo, J2
Cabrera, J2
Estévez, F2
Loro, J1
Reiter, RJ2
Quintana, J2
Yamanishi, M1
Narazaki, H1
Asano, T1
Quintana, C1
Loro, JF1
Casado-Zapico, S1
Martín, V1
García-Santos, G1
Rodríguez-Blanco, J1
Sánchez-Sánchez, AM1
Luño, E1
Suárez, C1
García-Pedrero, JM1
Menendez, ST1
Antolín, I1
Rodriguez, C1
Vanderstraeten, J1
Verschaeve, L1
Burda, H1
Bouland, C1
de Brouwer, C1
Büyükavci, M1
Ozdemir, O1
Buck, S1
Stout, M1
Ravindranath, Y1
Savaşan, S1
Henshaw, DL1
Ward, JP1
Matthews, JC1
Anwar, MM1
Mahfouz, HA1
Sayed, AS1
Smith, JA1
Mee, TJ1
Barnes, ND1
Thorburn, RJ1
Barnes, JL1
Raĭkhlin, NT1
Kvetnoĭ, IM1

Reviews

4 reviews available for melatonin and Leukemia

ArticleYear
Melatonin: A promising agent targeting leukemia.
    Journal of cellular biochemistry, 2020, Volume: 121, Issue:4

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Cell Proliferation; DNA Damage; Gene Expr

2020
Potential role of melatonin in prevention and treatment of leukaemia.
    Hormone molecular biology and clinical investigation, 2021, Aug-06, Volume: 42, Issue:4

    Topics: Animals; Apoptosis; Cell Proliferation; Disease Management; Humans; Leukemia; Melatonin; Outcome Ass

2021
Health effects of extremely low-frequency magnetic fields: reconsidering the melatonin hypothesis in the light of current data on magnetoreception.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:12

    Topics: Animals; Breast Neoplasms; Circadian Rhythm; Environmental Exposure; Female; Humans; Leukemia; Magne

2012
Can disturbances in the atmospheric electric field created by powerline corona ions disrupt melatonin production in the pineal gland?
    Journal of pineal research, 2008, Volume: 45, Issue:4

    Topics: Adult; Air Pollutants; Animals; Atmosphere; Child; Circadian Rhythm; Electromagnetic Fields; Humans;

2008

Other Studies

13 other studies available for melatonin and Leukemia

ArticleYear
Melatonin Can Enhance the Effect of Drugs Used in the Treatment of Leukemia.
    Biochemistry. Biokhimiia, 2023, Volume: 88, Issue:1

    Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Leukemia; Mel

2023
Melatonin secretion following brain midline irradiation is diminished, but not correlated with subjective sleep disturbances.
    Clinical endocrinology, 2018, Volume: 89, Issue:6

    Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Cross-Sectional Studies; Female; Humans; Leukemia;

2018
Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways.
    Cancer letters, 2019, 02-28, Volume: 443

    Topics: Animals; Antigens, Nuclear; Cell Line, Tumor; Cell Proliferation; Child; Child, Preschool; Cyclooxyg

2019
Targeting miR-193a-AML1-ETO-β-catenin axis by melatonin suppresses the self-renewal of leukaemia stem cells in leukaemia with t (8;21) translocation.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:8

    Topics: Animals; Apoptosis; beta Catenin; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Self Ren

2019
Nanoarchitectured electrochemical cytosensors for selective detection of leukemia cells and quantitative evaluation of death receptor expression on cell surfaces.
    Analytical chemistry, 2013, Jun-04, Volume: 85, Issue:11

    Topics: Antioxidants; Biosensing Techniques; Carbon; Electrochemical Techniques; Electrodes; Ferric Compound

2013
Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells.
    Journal of pineal research, 2013, Volume: 55, Issue:2

    Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Cell Line, Tumor; Cytochromes c; Dru

2013
Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase.
    Experimental hematology, 2015, Volume: 43, Issue:3

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; Clofarabine; Deoxy

2015
Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells.
    Journal of pineal research, 2016, Volume: 61, Issue:3

    Topics: Apoptosis; Caspases; HL-60 Cells; Humans; Hypothermia, Induced; K562 Cells; Leukemia; Melatonin; Neo

2016
Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients.
    Journal of pineal research, 2011, Volume: 50, Issue:3

    Topics: Apoptosis; Blotting, Western; Caspase 3; Fas Ligand Protein; fas Receptor; HL-60 Cells; Humans; Leuk

2011
Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:1

    Topics: Apoptosis; Cell Survival; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Jurkat Cells; Leuke

2006
Potential protective effects of melatonin on bone marrow of rats exposed to cytotoxic drugs.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 1998, Volume: 119, Issue:2

    Topics: Acid Phosphatase; Adjuvants, Immunologic; Alkaline Phosphatase; Animals; Bone Marrow Cells; Cell Sur

1998
Melatonin in serum and cerebrospinal fluid.
    Lancet (London, England), 1976, Aug-21, Volume: 2, Issue:7982

    Topics: Child; Child, Preschool; Female; Humans; Leukemia; Male; Melatonin

1976
[Dynamics of changes in enterochromaffin cells during tumor growth].
    Voprosy onkologii, 1976, Volume: 22, Issue:1

    Topics: Chromaffin System; Enterochromaffin Cells; Gastrointestinal Neoplasms; Humans; Hyperplasia; Leukemia

1976